4-Aminobutyrate Transaminase
Transaminases
Aminobutyrates
Alanine Transaminase
Aminocaproates
Pyridoxamine
Ketoglutaric Acids
Aspartate Aminotransferases
Succinate-Semialdehyde Dehydrogenase
An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
GABA Plasma Membrane Transport Proteins
A family of plasma membrane neurotransmitter transporter proteins that regulates extracellular levels of the inhibitory neurotransmitter GAMMA-AMINOBUTYRIC ACID. They differ from GABA RECEPTORS, which signal cellular responses to GAMMA-AMINOBUTYRIC ACID. They control GABA reuptake into PRESYNAPTIC TERMINALS in the CENTRAL NERVOUS SYSTEM through high-affinity sodium-dependent transport.
D-Alanine Transaminase
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Glutamates
Organic Anion Transporters
A correlation between changes in gamma-aminobutyric acid metabolism and seizures induced by antivitamin B6. (1/160)
The effects of DL-penicillamine (DL-PeA), hydrazine and toxopyrimidine (TXP, 2-methyl-6-amino-5-hydroxymethylpyrimidine) on gamma-aminobutyric acid (GABA) metabolism in mouse brain were studied. All these compounds inhibited the activity of glutamate decarboxylase [EC 4.1.1.15] (GAD) and slightly inhibited that of 4-aminobutyrate: 2-oxoglutarate aminotransferase [EC 2.6.1.19] (GABA-T). In contrast, very different effects were observed on GABA levels; hydrazine caused a marked increase, DL-PeA had no effect, and TXP caused a slight decrease in the content of the amino acid. These results could be described by an equation which related the excitable state to changes in the flux of the GABA bypass. Since the values obtained from the equation clearly reflect the seizure activity, it is suggested that the decreased GABA flux might be a cause of convulsions induced by these drugs. (+info)The irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA blocks cocaine self-administration in rats. (2/160)
gamma-Vinyl gamma-aminobutyric acid (GABA) (GVG) is an irreversible inhibitor of GABA transaminase, the primary enzyme involved in GABA metabolism. Acute administration of GVG increases brain GABA levels and blocks cocaine-induced locomotor activity, cocaine-induced lowering of brain stimulation reward thresholds, and cocaine-induced conditioned place preference. To further evaluate the effects of GVG on cocaine-induced reward, we examined its effects on cocaine self-administration in male Wistar rats on fixed ratio 5 and progressive ratio schedules of reinforcement. Additionally, the effects of GVG on operant responding for a food reward were examined on the same two schedules to determine whether the effects of GVG were specific to cocaine reward or generalized to other types of reward. GVG dose dependently decreased responding for cocaine on both schedules of reinforcement, suggesting that GVG attenuated the reward value of the cocaine. Responding for food was also decreased by GVG, suggesting that the effects of increased GABA levels induced by GVG may have a general effect on central reward systems. Data from this and other studies indicate that GVG does not induce motor impairment, decrease spontaneous locomotor activity, or induce catalepsy. Taken together, these data suggest that increases in GABAergic activity induced by GVG have an attenuating effect on centrally mediated reward systems and that the GABA system may be a useful target in the development of new therapeutic strategies for cocaine addiction. (+info)The mature size of rat 4-aminobutyrate aminotransferase is different in liver and brain. (3/160)
The amino acid sequence predicted from a rat liver cDNA library indicated that the precursor of beta-AlaAT I (4-aminobutyrate aminotransferase, beta-alanine-oxoglutarate aminotransferase) consists of a mature enzyme of 466 amino acid residues and a 34-amino acid terminal segment, with amino acids attributed to the leader peptide. However, the mass of beta-AlaAT I from rat brain was larger than that from rat liver and kidney, as assessed by Western-blot analysis, mass spectroscopy and N-terminal sequencing. The mature form of beta-AlaAT I from the brain had an ISQAAAK- peptide on the N-terminus of the liver mature beta-AlaAT I. Brain beta-AlaAT I was cleaved to liver beta-AlaAT I when incubated with fresh mitochondrial extract from rat liver. These results imply that mature rat liver beta-AlaAT I is proteolytically cleaved in two steps. The first cleavage of the motif XRX( downward arrow)XS is performed by a mitochondrial processing peptidase, yielding an intermediate-sized protein which is the mature brain beta-AlaAT I. The second cleavage, which generates the mature liver beta-AlaAT I, is also carried out by a mitochondrial endopeptidase. The second peptidase is active in liver but lacking in brain. (+info)Effects of blocking GABA degradation on corticotropin-releasing hormone gene expression in selected brain regions. (4/160)
PURPOSE: The gamma-aminobutyric acid (GABA) degradation blocker gamma-vinyl-GABA (VGB) is used clinically to treat seizures in both adult and immature individuals. The mechanism by which VGB controls developmental seizures is not fully understood. Specifically, whether the anticonvulsant properties of VGB arise only from its elevation of brain GABA levels and the resulting activation of GABA receptors, or also from associated mechanisms, remains unresolved. Corticotropin-releasing hormone (CRH), a neuropeptide present in many brain regions involved in developmental seizures, is a known convulsant in the immature brain and has been implicated in some developmental seizures. In certain brain regions, it has been suggested that CRH synthesis and release may be regulated by GABA. Therefore we tested the hypothesis that VGB decreases CRH gene expression in the immature rat brain, consistent with the notion that VGB may decrease seizures also by reducing the levels of the convulsant molecule, CRH. METHODS: VGB was administered to immature, 9-day-old rats in clinically relevant doses, whereas littermate controls received vehicle. RESULTS: In situ hybridization histochemistry demonstrated a downregulation of CRH mRNA levels in the hypothalamic paraventricular nucleus but not in other limbic regions of VGB-treated pups compared with controls. In addition, VGB-treated pups had increased CRH peptide levels in the anterior hypothalamus, as shown by radioimmunoassay. CONCLUSIONS: These findings are consistent with a reduction of both CRH gene expression and secretion in the hypothalamus, but do not support an indirect anticonvulsant mechanism of VGB via downregulation of CRH levels in limbic structures. However, the data support a region-specific regulation of CRH gene expression by GABA. (+info)Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats. (5/160)
A dopaminergic system in the zona incerta stimulates LH release and may mediate the positive feedback effects of the gonadal steroids on LH release. In this study the mechanisms by which steroids might increase dopamine activity in the zona incerta were investigated. In addition, experiments were conducted to determine whether the inhibitory effects of gamma-aminobutyric acid (GABA) on LH release in the zona incerta are due to suppression of dopamine activity in this area or conversely whether the stimulatory effects of dopamine on LH release are due to suppression of a tonic inhibitory GABAergic system. Ovariectomized rats were treated s.c. with oil, 5 micrograms oestradiol benzoate or 5 micrograms oestradiol benzoate followed 48 h later by 0.5 mg progesterone, and killed 54 h after the oestradiol benzoate injection. At this time the LH concentrations were suppressed in the oestradiol benzoate group and increased in the group treated with oestradiol benzoate and progesterone. The ratio of tyrosine hydroxylase:beta-actin mRNA in the zona incerta was significantly increased by the oestradiol benzoate treatment, but the addition of progesterone resulted in values similar to those in the control group. At the same time, the progesterone treatment increased tyrosine hydroxylase activity in the zona incerta as indicated by an increase in L-dihydroxyphenylalanine (L-DOPA) accumulation after 100 mg 3-hydroxybenzylhydrazine hydrochloric acid (NSD1015) kg-1 and an increase in dopamine release as indicated by a increase in dihydroxyphenylacetic acid (DOPAC) concentrations (one of the major metabolites of dopamine). Ovariectomized rats treated with oestradiol benzoate plus progesterone were also injected i.p. with 75 mg gamma-acetylenic GABA kg-1 (a GABA transaminase inhibitor) to increase GABA concentrations in the brain. This treatment had no effect on the ratio of tyrosine hydroxylase:beta-actin mRNA but decreased L-DOPA accumulation and DOPAC concentrations in the zona incerta, indicating a post-translational inhibition of dopamine synthesis and release. Treatment of ovariectomized rats with oestradiol benzoate followed by 100 mg L-DOPA i.p. to increase dopamine concentrations in the whole brain had no effect on glutamic acid decarboxylase mRNA expression in the zona incerta, although it increased the glutamic acid decarboxylase:beta-actin mRNA ratio in other hypothalamic areas (that is, the medical preoptic area, ventromedial nucleus and arcuate nucleus). In conclusion, the steroids act to increase dopamine activity in different ways: oestrogen increases tyrosine hydroxylase mRNA expression and progesterone acts after translation to increase tyrosine hydroxylase activity and dopamine release (as indicated by increases in DOPAC concentrations). This latter effect may be due to progesterone removing a tonic GABAergic inhibition from the dopaminergic system. (+info)The inhibitory effects of (gamma)-aminobutyric acid (GABA) on growth hormone secretion in the goldfish are modulated by sex steroids. (6/160)
Double-labelling studies at the electron microscopic level demonstrated that gamma-aminobutyric acid (GABA)-immunoreactive nerve endings are associated with growth-hormone-secreting cells in the proximal pars distalis of the goldfish pituitary gland, suggesting that GABA may be important for the control of growth hormone release in this species. An in vitro assay for GABA-transaminase activity demonstrated that the pituitary is a site for the metabolism of GABA to succinic acid. In vitro, GABA or the GABA antagonists bicuculline and saclofen did not affect the rate of growth hormone release from dispersed pituitary cells in static incubation. In contrast, intracerebroventricular injection of GABA reduced serum growth hormone levels within 30 min. During the seasonal gonadal cycle, intraperitoneal injection of GABA was without effect in sexually regressed goldfish, but caused a significant decrease in serum growth hormone levels in sexually recrudescent animals. Intraperitoneal implantation of solid silastic pellets containing oestradiol increased serum GH levels fivefold in sexually regressed and recrudescent goldfish; in both groups, GABA suppressed the oestradiol-stimulated increase in circulating growth hormone levels. The effect of oestradiol on basal serum growth hormone levels was specific since progesterone and testosterone were without effect. However, in recrudescent animals treated with progesterone and testosterone, the inhibitory effects of GABA on serum growth hormone levels were absent, indicating a differential role for these steroids in growth hormone release. Taken together, these results demonstrate that GABA has an inhibitory effect on growth hormone release in goldfish. (+info)Recovery of visual field constriction following discontinuation of vigabatrin. (7/160)
Epilepsy patients treated with vigabatrin may develop symptomatic or asymptomatic concentric visual field constriction due to GABA-associated retinal dysfunction. The prevalence and course of this side effect are not established yet; in previously reported adult patients the visual disturbances seem to be irreversible. We present two patients with a significant improvement of visual field constriction and retinal function after the discontinuation of vigabatrin. These findings suggest that vigabatrin-associated retinal changes are at least partly reversible in some patients, and that these patients may benefit significantly from a withdrawal of vigabatrin. Larger scale clinical studies are needed to identify predictive factors both for the occurrence and reversibility of vigabatrin-associated visual field defects. (+info)Increased mesolimbic GABA concentration blocks heroin self-administration in the rat. (8/160)
Opiate reinforcement has been hypothesized to be mediated by an inhibition of mesolimbic gamma-aminobutyric acid (GABA) release that subsequently disinhibits ventral tegmental area (VTA) dopamine neurons. In support of this hypothesis, this study demonstrates that when administered directly into the lateral ventricle, the VTA, or the ventral pallidum, but not the nucleus accumbens, gamma-vinyl-GABA (GVG, an irreversible GABA-transaminase inhibitor, 20-50 microg) dose dependently blocked heroin (0.06 mg/kg) self-administration (SA), as assessed by an increase in heroin SA at low doses of GVG and an initial increase followed 1 to 2 h later by a blockade of heroin SA at higher GVG doses. This effect lasted 3 to 5 days. In drug-naive rats, intra-VTA GVG pretreatment also prevented or delayed acquisition of heroin SA for 2 days. This GVG effect was prevented or reversed by systemic or intra-VTA pretreatment with the GABA(B) antagonist 2-hydroxysaclofen, but not the GABA(A) antagonist bicuculline. Similarly, coadministration of heroin with aminooxy-acetic acid (1-4 mg/kg) or ethanolamine-O-sulfate (50-100 mg/kg), two reversible GABA transaminase inhibitors, dose dependently reduced heroin reinforcement. Coadministration of (+/-)-nipecotic acid (0.1-5 mg/kg) with heroin, or intra-VTA or -ventral pallidum pretreatment with (+/-)-nipecotic acid (10 microg) or NO-711 (2 microg), two GABA uptake inhibitors, significantly increased heroin SA behavior, an effect also blocked by systemic 2-hydroxysaclofen, but not bicuculline. Taken together, these experiments, for the first time, demonstrate that pharmacological elevation of mesolimbic GABA concentration blocks heroin reinforcement by activating GABA(B) receptors, supporting the GABAergic hypothesis of opiate reinforcement and the incorporation of GABA agents in opiate abuse treatment. (+info)
GFIT result for T02256
GFIT result for T00913
GABA-T - Glutamic Acid Decarboxylase and GABA Transaminase | AcronymFinder
gabT - 4-aminobutyrate aminotransferase - Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) - gabT gene & protein
Alfa Aesar™ tert-Butyl (S)-2-aminobutyrate hydrochloride, 95% 25g Alfa Aesar™ tert-Butyl (S)-2-aminobutyrate hydrochloride, 95%
Sequence Similarity Search - BLAST
Sequence Similarity Search - BLAST
The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance | BMC Plant Biology | Full...
GABA-T - What does GABA-T stand for? The Free Dictionary
RCSB PDB - Protein Feature View
- 4-aminobutyrate aminotransferase GabT - B2HN70 (B2HN70 MYCMM)
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Early Preclinical Work Leading to the Development of Gabapentin - Medicinal Chemistry
Anti-ABAT/GABA-T antibody (ab152134) | Abcam
EC 2.6.1.65
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endogenous benzodiazepines
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Fatty Acid Synthase
ABAT Antibody (PA5-43723)
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Aminobutyric Acids
- Aminobutyric Acid
Summary Report | CureHunter
γ-Aminobutyric acid stimulates intrinsic inhibitory and excitatory nerves in the guinea-pig intestine<...
The Occurrence of 7-Aminobutyric Acid (GABA)-Containing Cells in Cultures of Retinas from the Human Fetus - Semantic Scholar
PathWhiz
Aminobutyric Acid (GABA), γ-[2,3-3H(N)]-, Specific Activity: 70-100Ci (2.59-3.70TBq)/mMole, 250µCi (9.25MBq) | PerkinElmer
Aminobutyric Acid (GABA), γ-[2,3-3H(N)]-, Specific Activity: 70-100Ci (2.59-3.70TBq)/mMole, 1mCi (37MBq) | PerkinElmer
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4-aminobutyrate transaminase
As a transaminase, GABA-T's role is to move functional groups from an amino acid and a α-keto acid, and vice versa. In the case ... "GABA-TRANSAMINASE DEFICIENCY". www.omim.org. Retrieved 2020-10-18. Fait A, Fromm H, Walter D, Galili G, Fernie AR (January 2008 ... This means that it is in the transferase class of enzymes, the nitrogenous transferase sub-class and the transaminase sub- ... Parviz M, Vogel K, Gibson KM, Pearl PL (November 2014). "Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies ...
4-aminobutyrate-pyruvate transaminase
... pyruvate transaminase (EC 2.6.1.96, aminobutyrate aminotransferase, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate ... aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, POP2 (gene)) is an enzyme with ... gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric transaminase, 4- ... and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate". ...
ABAT
Vigabatrin is a drug that is irreparably suppresses GABA transaminase that causes increased amount of GABA in the brain. In a ... Rainesalo S, Saransaari P, Peltola J, Keränen T (March 2003). "Uptake of GABA and activity of GABA-transaminase in platelets ... This gene goes by a number of names, including, GABA transaminase, GABAT, 4-aminobutyrate transaminase, NPD009 etc. This gene ... Jeremiah S, Povey S (July 1981). "The biochemical genetics of human gamma-aminobutyric acid transaminase". Annals of Human ...
Gamma-aminobutyrate transaminase
... may refer to: 4-aminobutyrate-pyruvate transaminase, an enzyme 4-aminobutyrate transaminase, ...
Succinic semialdehyde dehydrogenase deficiency
Under normal conditions, SSADH works with the enzyme GABA transaminase to convert GABA to succinic acid. Succinic acid can then ... Vigabatrin is an irreversible inhibitor of GABA transaminases which leads to decreased levels of GHB and elevation of GABA. ... Parviz, M.; Vogel, K.; Gibson, K.M.; Pearl, P.L. (2014). "Disorders of GABA Metabolism: SSADH and GABA-transaminase ... The absence of SSADH leads to a 30-fold increase of GHB and a 2-4 fold increase of GABA in the brains of patients with SSADH ...
GABT
... may refer to: 4-aminobutyrate transaminase, an enzyme GabT RNA motif This disambiguation page lists articles associated ...
Beta-alanine aminotransferase
... may refer to: Alanine transaminase, an enzyme 4-aminobutyrate transaminase, an enzyme This set ...
GABA transferase
... may refer to: 4-aminobutyrate transaminase, an enzyme 4-aminobutyrate-pyruvate transaminase, an enzyme This ...
GABA aminotransferase
... may refer to: 4-aminobutyrate-pyruvate transaminase, an enzyme 4-aminobutyrate transaminase, an enzyme ...
Aminobutyrate aminotransferase
... may refer to: 4-aminobutyrate-pyruvate transaminase, an enzyme 4-aminobutyrate transaminase, an ...
Gamma-aminobutyric transaminase
... may refer to: 4-aminobutyrate-pyruvate transaminase, an enzyme 4-aminobutyrate transaminase, an ...
Gamma-aminobutyrate aminotransaminase
... may refer to: 4-aminobutyrate-pyruvate transaminase, an enzyme 4-aminobutyrate ... transaminase, an enzyme This set index page lists enzyme articles associated with the same name. If an internal link led you ...
4-aminobutyrate aminotransferase
... may refer to: 4-aminobutyrate transaminase, an enzyme 4-aminobutyrate-pyruvate transaminase, ...
Gamma-aminobutyric acid aminotransferase
... may refer to: 4-aminobutyrate-pyruvate transaminase, an enzyme 4-aminobutyrate ... transaminase, an enzyme This set index page lists enzyme articles associated with the same name. If an internal link led you ...
4-aminobutyric acid aminotransferase
... may refer to: 4-aminobutyrate-pyruvate transaminase, an enzyme 4-aminobutyrate ... transaminase, an enzyme This set index page lists enzyme articles associated with the same name. If an internal link led you ...
List of MeSH codes (D08)
... glycine transaminase MeSH D08.811.913.477.700.535 - leucine transaminase MeSH D08.811.913.477.700.550 - l-lysine 6-transaminase ... transaminases MeSH D08.811.913.477.700.100 - alanine transaminase MeSH D08.811.913.477.700.120 - 2-aminoadipate transaminase ... beta-alanine-pyruvate transaminase MeSH D08.811.913.477.700.347 - d-alanine transaminase MeSH D08.811.913.477.700.470 - ... tryptophan transaminase MeSH D08.811.913.477.700.900 - tyrosine transaminase MeSH D08.811.913.555.150 - amidinotransferases ...
Γ-Aminobutyric acid
The carboxylate form of GABA is γ-aminobutyrate. Two general classes of GABA receptor are known: GABAA in which the receptor is ... GABA transaminase enzymes catalyze the conversion of 4-aminobutanoic acid (GABA) and 2-oxoglutarate (α-ketoglutarate) into ... Parviz M, Vogel K, Gibson KM, Pearl PL (2014-11-25). "Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies". ... GABA reuptake inhibitors: deramciclane, hyperforin, tiagabine.[citation needed] GABA transaminase inhibitors: gabaculine, ...
POP2
... a gene related to the enzyme 4-aminobutyrate-pyruvate transaminase Pop 2 (mixtape), a 2017 mixtape by Charli XCX Pop2! The ...
N6-acetyl-beta-lysine transaminase
In enzymology, a N6-acetyl-beta-lysine transaminase (EC 2.6.1.65) is an enzyme that catalyzes the chemical reaction 6-acetamido ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... conversion of 6-N-acetyl-L-beta-lysine to 3-keto-6-acetamidohexanoate and of 4-aminobutyrate to succinic semialdehyde by ... different transaminases". Arch. Biochem. Biophys. 197 (1): 226-35. doi:10.1016/0003-9861(79)90240-6. PMID 44448. Portal: ...
Succinic semialdehyde
It is formed from GABA by the action of GABA transaminase and further oxidised to become succinic acid, which enters TCA cycle ... Succinic semialdehyde dehydrogenase deficiency 4-aminobutyrate aminotransferase Lide, David R. (1998), Handbook of Chemistry ...
Gabaculine
... a new potent inhibitor of gamma-aminobutyrate transaminase, on brain gamma-aminobutyrate content and convulsions in mice". Life ... Rando, Robert; Bangerter, F.W. (May 13, 1977). "The In Vivo Inhibition of GABA-transaminase by Gabaculine". Biochemical and ... gabaculine is extremely potent and toxic when compared to other GABA transaminase inhibitors, with an ED50 of 35 mg/kg and LD50 ... which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor. Gabaculine is also ...
List of EC numbers (EC 2)
... aspartate transaminase EC 2.6.1.2: alanine transaminase EC 2.6.1.3: cysteine transaminase EC 2.6.1.4: glycine transaminase EC ... D-amino-acid transaminase EC 2.6.1.11: acetylornithine transaminase EC 2.6.1.12: alanine-oxo-acid transaminase EC 2.6.1.13: ... neamine transaminase EC 2.6.1.94: 2′-deamino-2′-hydroxyneamine transaminase EC 2.6.1.95: neomycin C transaminase EC 2.6.1.96: 4 ... aminobutyrate-pyruvate transaminase EC 2.6.1.97: archaeosine synthase EC 2.6.1.98: UDP-2-acetamido-2-deoxy-ribo-hexuluronate ...
Succinate-semialdehyde dehydrogenase (NADP+)
... succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD)". ... 2 H+ This enzyme participates in the degradation of glutamate and 4-aminobutyrate. Bartsch K, von Johnn-Marteville A, Schulz A ...
Aminooxyacetic acid
I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino- ... Wolfgang Löscher; Dagmar Hönack; Martina Gramer (1989). "Use of Inhibitors of γ-Aminobutyric Acid (GABA) Transaminase for the ... Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) ... At concentrations high enough to fully inhibit 4-aminobutyrate aminotransferase activity, aminooxyacetic acid is indicated as a ...
ABAT gene: MedlinePlus Genetics
The ABAT gene provides instructions for making the GABA-transaminase enzyme. Learn about this gene and related health ... GABA-transaminase deficiency. At least 10 mutations in the ABAT gene have been identified in people with GABA-transaminase ... The ABAT gene mutations that cause GABA-transaminase deficiency lead to a shortage (deficiency) of functional GABA-transaminase ... The ABAT gene provides instructions for making the GABA-transaminase enzyme. This enzyme helps break down a brain chemical ( ...
Category:Commons category link is on Wikidata using P373 - wikidoc
Sequence search - BRENDA Enzyme Database
... and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate. ... Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in ... The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance. ...
Human Metabolome Database: Showing metabocard for (S)-beta-Aminoisobutyric acid (HMDB0002166)
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate ... 1. 4-aminobutyrate aminotransferase, mitochondrial. General function:. Involved in 4-aminobutyrate transaminase activity. ... InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1. ... InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 ... 4 N1 UNL 1 1.731 0.584 -0.423 1.00 0.00 N HETATM 5 C4 UNL 1 -1.072 0.941 -0.028 1.00 0.00 C HETATM 6 O1 UNL 1 -0.479 2.039 - ...
YRC Public Data Repository - Protein Overview - BIO3 / YNR058W
Indoor bacterial, fungal and viral species and functional genes in urban and rural schools in Shanxi Province, China...
Table 4 Association between the abundance of indoor microbial species and wheeze, rhinitis and rhinoconjunctivitis in high ... 4. LEfSe analysis for characteristic KEGG functional pathways in urban and rural dust samples in Shanxi, China. The second- ... 4. A higher abundance of genes related to human disease and the immune system was detected in urban schools, including "Human ... Each classroom was vacuumed for 4 min, vacuumed for 2 min on the floor and vacuumed for 2 min on the upper surfaces of desks, ...
Finding step gabT for putrescine catabolism in Desulfovibrio vulgaris Miyazaki F
... gamma-aminobutyrate transaminase. Score. Gene. Description. Similar to. Id.. Cov.. Bits. Other hit. Other id.. Other bits. ... succinylornithine transaminase (EC 2.6.1.81). 43%. 299.7. lo. DvMF_2502. glutamate-1-semialdehyde aminotransferase (RefSeq). 4- ... aminobutyrate transaminase subunit (EC 2.6.1.19) (characterized). 31%. 91%. 167.2. glutamate-1-semialdehyde 2,1-aminomutase (EC ... Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19) (characterized). 32%. 97%. 235.3. lysine-8-amino-7- ...
Jie Shen - Research output
- Research Profiles at Washington University School of Medicine
Shen, J., Wang, C., Ying, J., Xu, T., McAlinden, A. & OKeefe, R. J., Sep 19 2019, In: JCI Insight. 4, 18, e128568.. Research ... Chen, D., Shen, J. & Hui, T., 2015, In: F1000Research. 4, 1092.. Research output: Contribution to journal › Review article › ... Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice. ... 4, p. 516-527 12 p.. Research output: Contribution to journal › Article › peer-review ...
DeCS
Glutamine fructose 6-phosphate transaminase (isomerizing) [D08.811.913.477.700.500] Glutamine fructose 6-phosphate transaminase ... 4-aminobutirato transaminasa. Synonymes. GABA transaminasa aminobutirato aminotransferasa beta-alanina cetoglutarato ... 4-Aminobutyrate aminotransférase. bêta-Alanine-oxoglutarate aminotransférase. Code(s) darborescence:. D08.811.913.477.700.200 ... Contenu principal 1 Le menu 2 Recherche 3 Bas de page 4 ... L-Lysine 6-transaminase [D08.811.913.477.700.550] L-Lysine 6- ...
IMSEAR at SEARO: Search
HOMD :: SEQF1849
4-aminobutyrate transaminase. 43. SEQF1849,GL882573.1. EGF49898.1 jb [NA] [AA] 1581/526. 285255-286835. purine catabolism ... 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. 21. SEQF1849,GL882573.1. EGF49876.1 jb [NA] [AA] 501/166. ... putative L-ribulose-5-phosphate 4-epimerase. 87. SEQF1849,GL882573.1. EGF49942.1 jb [NA] [AA] 1443/480. 338742-337300. SPFH/ ... 4. SEQF1849,GL882579.1. EGF49188.1 jb [NA] [AA] 744/247. 4654-3911. conserved domain protein. ...
Code System Concept
2-oxoglutarate transaminase inhibitor Active Synonym false false 3520840017 Substance with 4-aminobutyrate - 2-oxoglutarate ... 4 Aminobutyrate aminotransferase inhibitor Active Synonym false false 3520604016 4-aminobutyrate - ... Substance with 4-aminobutyrate - 2-oxoglutarate transaminase inhibitor mechanism of action (substance). ... Substance with 4-aminobutyrate - 2-oxoglutarate transaminase inhibitor mechanism of action (substance). ...
B6db references : 79225517
4-Aminobutyrate Transaminase/*blood. abstract. Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the ... Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet ... transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. ...
Bio2Vec
YJR139C 267.488705 INESSENTIAL HOM6 "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase),5-amino-6-(5...
... "gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase),4-aminobutyrate aminotransferase, " YGR072W 8.896687 ... "phosphoserine transaminase,phosphoserine aminotransferase," YHR025W 143.39381 INESSENTIAL THR1 "homoserine kinase,homoserine ... "Branched-Chain Amino Acid Transaminase,branched-chain amino acid aminotransferase," YEL065W -0.945446 INESSENTIAL SIT1 " ... 4-dienoyl-CoA reductase (NADPH), peroxisomal matrix" YBR083W 4.939094 INESSENTIAL TEC1 "transcription factor of the TEA ATTS ...
DeCS 2018 - July 31, 2018 version
GABA Transaminase use 4-Aminobutyrate Transaminase GABA Transporter 1 use GABA Plasma Membrane Transport Proteins ... GABA alpha Ketoglutarate Aminotransferase use 4-Aminobutyrate Transaminase GABA Aminotransferase use 4-Aminobutyrate ... G Protein Coupled Inwardly Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ... G Protein-Coupled Inwardly-Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ...
DeCS
4-Amino-5-hexenoic Acid Previous Indexing:. Aminocaproic Acids (1981-1994). GABA/analogs & derivatives (1979-1980). GABA/ ... Es un inhibidor irreversible de la 4-AMINOBUTIRATO TRANSAMINASA, la enzima responsable del catabolismo del ÁCIDO GAMMA- ... It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA- ... It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA- ...
TARGET: Search Results
Diganta Das | USC Profiles
BiGG Gene 18 AT1
Alcohol Withdrawal in the Inpatient Setting
The irreversible gamma-aminobutyrate transaminase inhibitor vigabatrin in the treatment of the alcohol withdrawal syndrome. ... 4. Rehm J, Gmel G, Sempos CT, Trevisan M. Alcohol-related morbidity and mortality. Alcohol Res Health. 2003;27(1):39-51.. 5. ... 2015;75(4):353-365.. 7. Muzyk AJ, Rogers RE, Dighe G, et al. Impact of an alcohol withdrawal treatment pathway on hospital ... 2018;44(4):418-425.. 20. Sachdeva A, Choudhary M, Chandra M. Alcohol withdrawal syndrome: benzodiazepines and beyond. J Clin ...
Gamma aminobutyric acid transaminase deficiency - Rare Gastroenterology News
Parviz, M. et al.. Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies. J Pediatr Epilepsy. 2014 Nov 25; 3(4 ... also known as GABA-transaminase or GABA-T.[1] Mutations. in the ABAT gene. can cause less GABA-T to be made, a condition known ... GABA-TRANSAMINASE DEFICIENCY. OMIM. Dec 2009; https://omim.org/entry/613163. Accessed 3/20/2015. ... is a searchable database of medical literature and lists journal articles that discuss Gamma aminobutyric acid transaminase ...
Online Medical Dictionary: 4
DeCS 2017 - December 21, 2017 version
GABA Transaminase use 4-Aminobutyrate Transaminase GABA Transporter 1 use GABA Plasma Membrane Transport Proteins ... GABA alpha Ketoglutarate Aminotransferase use 4-Aminobutyrate Transaminase GABA Aminotransferase use 4-Aminobutyrate ... G Protein Coupled Inwardly Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ... G Protein-Coupled Inwardly-Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ...
DeCS 2016 - June 12, 2016 version
GABA Transaminase use 4-Aminobutyrate Transaminase GABA Transporter 1 use GABA Plasma Membrane Transport Proteins ... GABA alpha Ketoglutarate Aminotransferase use 4-Aminobutyrate Transaminase GABA Aminotransferase use 4-Aminobutyrate ... G Protein Coupled Inwardly Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ... G Protein-Coupled Inwardly-Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ...
DeCS 2017 - July 04, 2017 version
GABA Transaminase use 4-Aminobutyrate Transaminase GABA Transporter 1 use GABA Plasma Membrane Transport Proteins ... GABA alpha Ketoglutarate Aminotransferase use 4-Aminobutyrate Transaminase GABA Aminotransferase use 4-Aminobutyrate ... G Protein Coupled Inwardly Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ... G Protein-Coupled Inwardly-Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ...
DeCS 2018 - July 31, 2018 version
GABA Transaminase use 4-Aminobutyrate Transaminase GABA Transporter 1 use GABA Plasma Membrane Transport Proteins ... GABA alpha Ketoglutarate Aminotransferase use 4-Aminobutyrate Transaminase GABA Aminotransferase use 4-Aminobutyrate ... G Protein Coupled Inwardly Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ... G Protein-Coupled Inwardly-Rectifying Potassium Channel 4 use G Protein-Coupled Inwardly-Rectifying Potassium Channels ...
Tryptophan Transaminase | Colorado PROFILES
"Tryptophan Transaminase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Tryptophan Transaminase" by people in this website by year, ... Below are the most recent publications written about "Tryptophan Transaminase" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Tryptophan Transaminase". ...
IBS Publications Repository: Browsing DSpace
List of EC numbers (EC 2)
alanine transaminase. *: cysteine transaminase. *: glycine transaminase. *: tyrosine transaminase. *: leucine transaminase. *: ... thyroid-hormone transaminase. *: tryptophan transaminase. *: tryptophan-phenylpyruvate transaminase. *: diamine transaminase. ... glutamine-scyllo-inositol transaminase. *: serine-pyruvate transaminase. *: phosphoserine transaminase. *: now EC 1.4.1.13. *: ... valine-pyruvate transaminase. *: 2-aminohexanoate transaminase. *: ornithine(lysine) transaminase. *: now EC 2.6.1.11. *: ...
Aminotransferase4
- 4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency. (medlineplus.gov)
- Hypersomnolence-hyperkinetic movement disorder in a child with compound heterozygous mutation in 4-aminobutyrate aminotransferase (ABAT) gene. (medlineplus.gov)
- Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors. (unipr.it)
- 1] GABA is broken down in the body by a substance known as 4-aminobutyrate aminotransferase, also known as GABA-transaminase or GABA-T.[1] Mutations in the ABAT gene can cause less GABA-T to be made, a condition known as GABA-T deficiency . (rareginews.com)
GABA9
- The ABAT gene provides instructions for making the GABA-transaminase enzyme. (medlineplus.gov)
- At least 10 mutations in the ABAT gene have been identified in people with GABA-transaminase deficiency, which is a brain disease (encephalopathy) that begins in infancy. (medlineplus.gov)
- The ABAT gene mutations that cause GABA-transaminase deficiency lead to a shortage (deficiency) of functional GABA-transaminase enzyme. (medlineplus.gov)
- This accumulation alters the balance of neurotransmitters in the brain, leading to the neurological problems characteristic of GABA-transaminase deficiency. (medlineplus.gov)
- Mutants of GABA transaminase (POP2) suppress the severe phenotype of succinic semialdehyde dehydrogenase (ssadh) mutants in Arabidopsis. (brenda-enzymes.org)
- The Arabidopsis pop2-1 mutant reveals the involvement of GABA transaminase in salt stress tolerance. (brenda-enzymes.org)
- Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. (sc-ctsi.org)
- Gamma-aminobutyric acid transaminase (GABA-T) deficiency is an extremely rare disorder of GABA metabolism characterized by a severe neonatal-infantile epileptic encephalopathy (manifesting with symptoms such as seizures, hypotonia, hyperreflexia and developmental delay) and growth acceleration. (nih.gov)
- A gamma-amino butyric acid metabolism disorder that is characterized by a defect in the gene coding for gamma-aminobutyrate transaminase, which is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. (nih.gov)
Tryptophan Transaminase3
- Tryptophan Transaminase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
- This graph shows the total number of publications written about "Tryptophan Transaminase" by people in this website by year, and whether "Tryptophan Transaminase" was a major or minor topic of these publications. (ucdenver.edu)
- Below are the most recent publications written about "Tryptophan Transaminase" by people in Profiles. (ucdenver.edu)
Inhibitor1
- It is an irreversible inhibitor of 4-AMINOBUTYRATE TRANSAMINASE, the enzyme responsible for the catabolism of GAMMA-AMINOBUTYRIC ACID and is used as an anticonvulsant. (bvsalud.org)
Mutations1
- the most common, HH type 1, is caused primarily by homozygosity for the C282Y mutation in the hemochromatosis protein (HFE).3 Iron overload disease develops in up to 30% of these individuals and can result in significant hepatic, pancreatic, cardiac, or musculoskeletal tissue damage.4 Juvenile, or HH type 2, is rare and is caused by mutations in hemojuvelin (HJV) or hepcidin (HAMP). (kspinhibitors.com)
20221
- 23(4)2022 Feb 16. (bvsalud.org)
Transaminasa1
- Es un inhibidor irreversible de la 4-AMINOBUTIRATO TRANSAMINASA, la enzima responsable del catabolismo del ÁCIDO GAMMA-AMINOBUTÍRICO, y se utiliza como anticonvulsivo. (bvsalud.org)
Activity1
- Plasma alanine transaminase (ALT) activity, liver histology, and collagen deposition were evaluated to assess liver injury. (kspinhibitors.com)
Term1
- Medical term definitions of '4. (charmhtml.com)
Page1
- This is the entry page of medical terms started with 4. (charmhtml.com)
1.191
- activities of GAD and 4-aminobutyrate:2-oxoglutarate transaminase (GABA-T, EC.2.6.1.19), the enzyme responsible for the degradation of GABA, were determined in homogenates of tissue taken from six different brain regions. (bl.uk)
Alpha-ketoglutarate1
- Purification and properties of a diamine alpha-ketoglutarate transaminase from Escherichia coli. (unipr.it)
Deficiency1
- Gamma aminobutyric acid transaminase deficiency is a genetic disease, which means that it is caused by one or more genes not working correctly. (nih.gov)
Gamma1
- Purification of rat liver gamma-hydroxyglutamate transaminase and its probable identity with glutamate-aspartate transaminase. (unipr.it)
Dehydrogenase6
- The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). (patentsencyclopedia.com)
- The method includes culturing a non-naturally occurring microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway including at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase or α-ketoglutarate decarboxylase under substantially anaerobic conditions for a sufficient period of time to produce monomeric 4-hydroxybutanoic acid (4-HB). (patentsencyclopedia.com)
- 2. The non-naturally occurring microbial biocatalyst of claim 1, wherein said 4-HB biosynthetic pathway comprises 4-hydroxybutanoate dehydrogenase and succinyl-CoA synthetase and CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase. (patentsencyclopedia.com)
- 3. The non-naturally occurring microbial biocatalyst of claim 1, wherein said exogenous nucleic acid encodes 4-hydroxybutanoate dehydrogenase. (patentsencyclopedia.com)
- 7. The non-naturally occurring microbial biocatalyst of claim 1, wherein said microbial organism lacks an endogenous 4-HB biosynthetic activity selected from 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, and α-ketoglutarate decarboxylase. (patentsencyclopedia.com)
- Modifications focused on increase glucose consumption and reduce by-products formation together with the heterologous overexpression of the L-lysine decarboxylase, putrescine transaminase and putrescine dehydrogenase genes from E. coli in the L-lysine producer GRLys1 allowed production the glutarate precursor 5-aminovalerate. (omicsdi.org)
Metabolism2
- This summary NTP report on the metabolism, disposition, and toxicity studies of 1,4-butanediol is based partially on studies that took place from December 1988 through February 1989. (nih.gov)
- The draft summary report on the metabolism, disposition, and toxicity of 1,4-butanediol was evaluated by the reviewers listed below. (nih.gov)
People2
- This graph shows the total number of publications written about "Glycine Transaminase" by people in this website by year, and whether "Glycine Transaminase" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "Glycine Transaminase" by people in Profiles. (wakehealth.edu)
Development1
- National Cancer Institute 1 Introduction 1 Clinical investigations 3 Origins of the cancerous state 4 Development of clinical cancer 5 Autonomy 5 Spread of cancer 6 Wound washings 6 Cancer cells in circulating blood 7 Spread of tumor in animal models. (nih.gov)