An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.
Aminobenzoate derivatives that contain an amino group attached to carbon number 3 or 5 of the benzene ring structure.
Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.
Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
Aniline compounds, also known as aromatic amines, are organic chemicals derived from aniline (aminobenzene), characterized by the substitution of hydrogen atoms in the benzene ring with amino groups (-NH2).

N-acetylation of the heterocyclic amine batracylin by human liver. (1/255)

Batracylin (8-aminoisoindolo[1,2-b]quinazolin-12(10 H)-one; BAT) is a heterocyclic amine that exhibits antitumor activity in a number of in vivo and in vitro models. The acetyl product has been implicated in BAT toxicity in animals, cells, and bacteria. The ability of human N-acetyltransferase (NAT) to form this product was investigated. Nine human liver samples were analyzed for NAT1 and NAT2 genotypes. Seven of the samples possessed at least one NAT1*4 allele. Three samples contained one or more NAT2*4 allele and were classified as rapid acetylators. The remaining six had two alleles associated with the slow phenotype. NAT activities were evaluated with BAT, sulfamethazine (SMZ), a preferential substrate for human NAT2, and p-aminobenzoic acid, a substrate for NAT1. BAT activities in the nine donor samples ranged from 14.9 to 0.56 nmol/min/mg. The mean apparent K(m) values in rapid acetylators for BAT, SMZ, and p-aminobenzoic acid were 6.59 +/- 3.21, 278 +/- 69.4, and 31.2 +/- 12.5 microM, respectively. The apparent K(m) values for slow acetylators did not differ from the rapid acetylator phenotype. However, a significant difference in the apparent V(max) for BAT and SMZ was observed between rapid and slow acetylators. Comparing the apparent intrinsic clearance (V(max)/K(m)) for BAT and SMZ, a significant correlation (r(2) = 0.97, p <.001) was observed. These data demonstrate that BAT N-acetylation is similar to SMZ, and suggests that BAT is a preferential substrate for human NAT2. Thus, rapid acetylators would be more likely to develop toxicity when exposed to this drug.  (+info)

Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. (2/255)

The localization of 5-hydroxytryptamine(4) (5-HT(4)) receptors suggests their role in the regulation of dopamine (DA) neurotransmission, a speculation that has been supported by neurochemical studies. Mesolimbic DA systems play a prominent role in mediating the behavioral effects of the abused psychostimulant cocaine, and the intent of the present study was to assess the role of 5-HT(4) receptors in the control of spontaneous and cocaine-induced activity. Systemic administration of the 5-HT(4) receptor partial agonist 1-(4-amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]1-propa none hydrochloride (RS 67333; 0.0001-1 mg/kg) or the 5-HT(4) receptor antagonist 4-amino-5-chloro-2-methoxy-benzoic acid-(diethylamino)ethyl ester hydrochloride (SDZ 205,557; 0.0001-1 mg/kg) did not significantly alter spontaneous activity, whereas SDZ 205,557 significantly attenuated cocaine-induced horizontal activity and rearing. To test the hypothesis that cocaine-elicited behaviors were modulated by 5-HT(4) receptors in the nucleus accumbens (NAc) shell, two separate groups of male rats were implanted with bilateral cannulas aimed at the NAc shell. Intra-NAc shell microinjections of either RS 67333 (1 or 3 microgram/0.2 microliter/side) or SDZ 205,557 (1-5 microgram/0.2 microliter/side) did not alter spontaneous activity observed after a systemic saline injection but did significantly attenuate the hyperactivity induced by systemic cocaine injection (10 mg/kg). These results support an involvement of 5-HT(4) receptors, particularly those in the NAc shell, in the locomotor stimulatory effects of cocaine. Furthermore, these data suggest that 5-HT(4) receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.  (+info)

Increased levels of dihydrofolate reductase in rifampin-resistant mutants of Bacillus subtilis. (3/255)

Several independent, spontaneous rifampin-resistant mutants of Bacillus subtilis were isolated and found to have an increased resistance to trimethoprim, an inhibitor of dihydrofolate reductase. This increased resistance in the rif mutants was the result of a specific threefold increase in the activity of dihydrofolate reductase, since six other enzymes examined remained unchanged. This increased level of dihydrofolate reductase and the trimethoprim resistance were cotransformed (100%) with the rif marker. These results suggest that the RNA polymerase is altered in its recognition of the gene that specifies dihydrofolate reductase.  (+info)

N-Acetylation of paraphenylenediamine in human skin and keratinocytes. (4/255)

Skin is the major target of allergic reactions to paraphenylenediamine (PPD). Such small molecules require activation to become immunogenic. The balance between activation and/or detoxification processes is critical for immunogenic potentials of compounds. Therefore, we investigated N-acetylation (NAT) capacities of human skin for PPD to gain a better understanding of its mechanisms of action. PPD is acetylated to monoacetyl-PPD (MAPPD), which in turn is acetylated to N,N'-diacetyl-PPD (DAPPD). This was found using cytosolic fractions from human skin (n = 9) and cultured normal human epidermal keratinocytes (n = 7). The cutaneous activities for MAPPD formation ranged from 0.41 to 3.68 nmol/mg/min (9-fold variation) and DAPPD formation from 0.65 to 3.25 nmol/mg protein/min (5-fold), respectively. Similar results were obtained with keratinocytes. NAT activities toward both substrates, PPD and MAPPD, were correlated in keratinocytes (r = 0.930), suggesting that the reactions were catalyzed by the same enzyme. Formation of MAPPD and DAPPD was competitively inhibited in the presence of p-aminobenzoic acid (300 microM), a typical NAT1 substrate, but not by sulfamethazine. These kinetic characteristics suggest that the acetylation of PPD in human skin and keratinocytes is predominantly attributable to the polymorphic NAT1, although both mRNAs (NAT1 and NAT2) are synthesized in human skin and keratinocytes. The metabolism of PPD by NAT1 in human skin and keratinocytes as well as the virtual absence of NAT2 activity may have important toxicological implications. In the case of PPD, our results emphasize that N-acetylation status may be a susceptibility factor for the development of an allergy to PPD.  (+info)

Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. (5/255)

Arylamine N-acetyltransferase-1 (NAT1) is a polymorphically expressed enzyme that is widely distributed throughout the body. In the present study, we provide evidence for substrate-dependent regulation of this enzyme. Human peripheral blood mononuclear cells cultured in medium supplemented with p-aminobenzoic acid (PABA; 6 microM) for 24 h showed a significant decrease (50-80%) in NAT1 activity. The loss of activity was concentration-dependent (EC(50) approximately 2 microM) and selective because PABA had no effect on the activity of constitutively expressed lactate dehydrogenase or aspartate aminotransferase. PABA also induced down-regulation of NAT1 activity in several human cell lines grown at confluence. Substrate-dependent down-regulation was not restricted to PABA. Addition of other NAT1 substrates, such as p-aminosalicylic acid, ethyl-p-aminobenzoate, or p-aminophenol to peripheral blood mononuclear cells in culture also resulted in significant (P <.05) decreases in NAT1 activity. However, addition of the NAT2-selective substrates sulfamethazine, dapsone, or procainamide did not alter NAT1 activity. Western blot analysis using a NAT1-specific antibody showed that the loss of NAT1 activity was associated with a parallel reduction in the amount of NAT1 protein (r(2) = 0.95). Arylamines that did not decrease NAT1 activity did not alter NAT1 protein levels. Semiquantitative reverse transcriptase polymerase chain reaction of mRNA isolated from treated and untreated cells revealed no effect of PABA on NAT1 mRNA levels. We conclude that NAT1 can be down-regulated by arylamines that are themselves NAT1 substrates. Because NAT1 is involved in the detoxification/activation of various drugs and carcinogens, substrate-dependent regulation may have important consequences with regard to drug toxicity and cancer risk.  (+info)

Sensitive and selective determination of tetracaine and its metabolite in human samples by gas chromatography-mass spectrometry. (6/255)

A sensitive and reliable method was developed for the determination of tetracaine and its metabolite, p-butylaminobenzoic acid, in human samples. Tetracaine and the metabolite, effectively extracted using a liquid-liquid extraction procedure from 0.5 g of sample, were analyzed by gas chromatography-mass spectrometry. Tetracaine was analyzed without derivatization, and the metabolite was analyzed after tert-butylolimethylsilyl derivatization. Dibucaine and p-dimethylaminobenzoic acid were used as internal standards for tetracaine and the metabolite, respectively. The calibration curve for each compound was linear in the concentration range from 10 to 1,000 ng/0.5 g, and the lower limits of detection were 10 ng/g for tetracaine and 0.6 ng/g for the metabolite in whole blood and tissues. The accuracy and precision of the method were evaluated in whole blood and brain at the concentrations of 50 ng/0.5 g and 500 ng/0.5 g for tetracaine and 10 ng/0.5 g and 100 ng/0.5 g for the metabolite. The coefficients of variation ranged from 0.8 to 3.0% for tetracaine and 2.4 to 9.8% for the metabolite. We used this method to determine tetracaine and its metabolite in human whole blood and tissues of an autopsied patient who died during spinal anesthesia induced by tetracaine.  (+info)

Inhibition of the development of the cellular slime mould Dictyostelium discoideum by omega-aminocarboxylic acids. (7/255)

Four omega-aminocarboxylic acids - epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexane-1-carboxylic acid (t-AMCHA), p-aminomethylbenzoic acid (PAMBA) and omega-aminocaprylic acid (OACA) -- prevented fruiting body formation of the cellular slime mould Dictyostelium discoideum. At concentrations of 40 mM, 75 mM, 10 mM and 5 mM, respectively, they allowed aggregation but prevented all further development at 24 degrees C. At lower concentrations, EACA allowed fruiting body formation but with a reduced number of spores per fruiting body. Only t-AMCHA had a significant inhibitory effect on the growth of myxamoebae. EACA affected development only if it was present between 8 and 16 h after the cells were deposited on the filters. Its effect was enhanced by high salt concentrations and by higher temperature, and was also dependent on the manner in which the cells were grown. Only strains capable of axenic growth displayed this sensitivity to EACA, although strains carrying only one of the genetic markers for axenic growth (axe A) were partially sensitive.  (+info)

The effect of epsilon-aminocaproic acid on biochemical changes in the development of the cellular slime mould Dictyostelium discoideum. (8/255)

epsilon-Aminocaproic acid (EACA) inhibited the development of Dictyostelium discoideum strain AX2 after the aggregation stage. Biochemical changes that occurred early in development (loss of cellular protein, RNA and carbohydrate; increase in the specific activity of N-acetylglucosaminidase, alpha-mannosidase, threonine deaminase and leucine aminopeptidase) were not affected by concentrations of EACA which blocked development; but biochemical changes that occurred later (synthesis of carbohydrate, increase in the specific activity of UDP-glucose pyrophosphorylase) were inhibited. Spores from fruiting bodies formed in the presence of low concentrations of EACA were larger, more spherical and less able to survive heat treatment than spores from fruiting bodies of control (no EACA) cells.  (+info)

4-Aminobenzoic acid, also known as PABA or para-aminobenzoic acid, is an organic compound that is a type of aromatic amino carboxylic acid. It is a white, crystalline powder that is slightly soluble in water and more soluble in alcohol.

4-Aminobenzoic acid is not an essential amino acid for humans, but it is a component of the vitamin folic acid and is found in various foods such as meat, whole grains, and molasses. It has been used as a topical sunscreen due to its ability to absorb ultraviolet (UV) radiation, although its effectiveness as a sunscreen ingredient has been called into question in recent years.

In addition to its use in sunscreens, 4-aminobenzoic acid has been studied for its potential health benefits, including its possible role in protecting against UV-induced skin damage and its potential anti-inflammatory and analgesic effects. However, more research is needed to confirm these potential benefits and to determine the safety and effectiveness of 4-aminobenzoic acid as a dietary supplement or topical treatment.

Meta-Aminobenzoates are a group of compounds that contain a meta-substituted aminobenzoic acid structure. They are derivatives of p-aminobenzoic acid (PABA), where the amino group is substituted in the meta position of the benzene ring, rather than the para position as in PABA itself.

Meta-aminobenzoates have been used in various medical and cosmetic applications, including as sunscreen agents, pharmaceutical excipients, and topical anti-inflammatory agents. However, their use as sunscreen active ingredients has declined due to concerns about potential phototoxicity and skin sensitization.

One of the most well-known meta-aminobenzoates is 4-methylbenzylidene camphor (4-MBC), which was widely used as a UV absorber in sunscreens until it was banned or restricted in several countries due to its potential health risks.

It's worth noting that meta-aminobenzoates should not be confused with para-aminobenzoic acid (PABA) or its derivatives, which are also used in medical and cosmetic applications but have different chemical structures and properties.

Ortho-Aminobenzoates are chemical compounds that contain a benzene ring substituted with an amino group in the ortho position and an ester group in the form of a benzoate. They are often used as pharmaceutical intermediates, plastic additives, and UV stabilizers. In medical contexts, one specific ortho-aminobenzoate, para-aminosalicylic acid (PABA), is an antibiotic used in the treatment of tuberculosis. However, it's important to note that "ortho-aminobenzoates" in general do not have a specific medical definition and can refer to any compound with this particular substitution pattern on a benzene ring.

Aminobenzoates are a group of chemical compounds that contain an amino (NH2) group and a benzoate (C6H5COO-) group in their structure. They are widely used in the pharmaceutical and cosmetic industries due to their various properties, such as ultraviolet light absorption, antimicrobial activity, and anti-inflammatory effects.

One of the most well-known aminobenzoates is para-aminobenzoic acid (PABA), which is a naturally occurring compound found in some foods and also synthesized by bacteria in the human gut. PABA has been used as a topical sunscreen agent due to its ability to absorb ultraviolet B (UVB) radiation, but its use as a sunscreen ingredient has declined in recent years due to concerns about skin irritation and potential allergic reactions.

Other aminobenzoates have various medical uses, such as:

* Antimicrobial agents: Some aminobenzoates, such as benzalkonium chloride and cetylpyridinium chloride, are used as antiseptics and disinfectants due to their ability to disrupt bacterial cell membranes.
* Analgesic and anti-inflammatory agents: Aminobenzoates such as methyl salicylate and acetaminophen (paracetamol) are commonly used as pain relievers and fever reducers.
* Vitamin B supplements: PABA is a component of folic acid, which is an essential vitamin for human health. Some people take PABA supplements to treat or prevent various conditions, such as graying hair, rheumatoid arthritis, and vitiligo, although there is limited scientific evidence to support these uses.

It's important to note that some aminobenzoates can be toxic in high doses or with prolonged exposure, so they should be used under the guidance of a healthcare professional.

Peroxidase is a type of enzyme that catalyzes the chemical reaction in which hydrogen peroxide (H2O2) is broken down into water (H2O) and oxygen (O2). This enzymatic reaction also involves the oxidation of various organic and inorganic compounds, which can serve as electron donors.

Peroxidases are widely distributed in nature and can be found in various organisms, including bacteria, fungi, plants, and animals. They play important roles in various biological processes, such as defense against oxidative stress, breakdown of toxic substances, and participation in metabolic pathways.

The peroxidase-catalyzed reaction can be represented by the following chemical equation:

H2O2 + 2e- + 2H+ → 2H2O

In this reaction, hydrogen peroxide is reduced to water, and the electron donor is oxidized. The peroxidase enzyme facilitates the transfer of electrons between the substrate (hydrogen peroxide) and the electron donor, making the reaction more efficient and specific.

Peroxidases have various applications in medicine, industry, and research. For example, they can be used for diagnostic purposes, as biosensors, and in the treatment of wastewater and medical wastes. Additionally, peroxidases are involved in several pathological conditions, such as inflammation, cancer, and neurodegenerative diseases, making them potential targets for therapeutic interventions.

Aniline compounds, also known as aromatic amines, are organic compounds that contain a benzene ring substituted with an amino group (-NH2). Aniline itself is the simplest and most common aniline compound, with the formula C6H5NH2.

Aniline compounds are important in the chemical industry and are used in the synthesis of a wide range of products, including dyes, pharmaceuticals, and rubber chemicals. They can be produced by reducing nitrobenzene or by directly substituting ammonia onto benzene in a process called amination.

It is important to note that aniline compounds are toxic and can cause serious health effects, including damage to the liver, kidneys, and central nervous system. They can also be absorbed through the skin and are known to have carcinogenic properties. Therefore, appropriate safety measures must be taken when handling aniline compounds.

"Para-aminobenzoic acid". Medline Plus Medical Encyclopedia. United States National Institutes of Health. Retrieved 24 January ... Toxicity, Local Anesthetics: eMedicine Emergency Medicine "Aminobenzoic acid". Drug Information Portal. U.S. National Library ... "Synthesis of para-Amino Benzoic Acid-TiO2 Hybrid Nanostructures of Controlled Functionality by an Aqueous One-Step Process". ... "Synthesis of para-Amino Benzoic Acid-TiO2 Hybrid Nanostructures of Controlled Functionality by an Aqueous One-Step Process". ...
... (also known as meta-aminobenzoic acid or MABA) is an organic compound with the molecular formula ... It consists of a benzene ring substituted with an amino group and a carboxylic acid. Aminomethylbenzoic acid Anthranilic acid 4 ... Aminobenzoic acid Arene substitution pattern Non-proteinogenic amino acids m-Carboxyaniline - Compound Summary, PubChem. 3- ... aminobenzoic acid, Medical Subject Headings database. Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics ( ...
... (more precisely, 4-aminomethylbenzoic acid or p-aminomethylbenzoic acid, PAMBA) is an antifibrinolytic ... 4-Aminobenzoic acid Verstraete M (March 1985). "Clinical application of inhibitors of fibrinolysis". Drugs. 29 (3): 236-61. doi ...
Brill HC (June 1921). "Esters of Aminobenzoic Acids". Journal of the American Chemical Society. 43 (6): 1320-1323. doi:10.1021/ ... that is mildly soluble in water (1 part in 7000) and soluble in alcohol, ether, chloroform, fixed oils, and dilute acids. It ... Morogina OK, Nasibulin AA, Klyuev MV (1998). "Liquid-Phase Hydrogenation of p-Nitrobenzoic Acid Esters on Palladium Catalysts ... Hosangadi BD, Dave RH (August 1996). "An efficient general method for esterification of aromatic carboxylic acids". Tetrahedron ...
Examples in chemistry include tyrosine and 4-aminobenzoic acid. The former may be deprotonated to form the carboxylate and ...
"Safety data for p-nitrobenzoic acid". Archived from the original on 27 May 2008. Retrieved 11 April 2010. "p-Nitrobenzoic acid ... "Material Safety Data Sheet - P-nitrobenzoic acid MSDS". Archived from the original on 7 August 2011. Retrieved 11 April 2010. ( ... "Dissociation Constants Of Organic Acids And Bases". Retrieved 11 April 2010. "Bordwell pKa Table (Acidity in DMSO)". Retrieved ... ISBN 3527306730.. O. Kamm; A. O. Matthews (1922). "p-Nitrobenzoic Acid". Org. Synth. 2: 53. doi:10.15227/orgsyn.002.0053. " ...
Hypochlorous acid and tyrosyl radical are cytotoxic, so they are used by the neutrophil to kill bacteria and other pathogens. ... However, this hypochlorous acid may also cause oxidative damage in host tissue. Moreover, MPO oxidation of apoA-I reduces HDL- ... MPO is a member of the XPO subfamily of peroxidases and produces hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and ... MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to ...
Feit PW (May 1971). "Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamylbenzoic acid derivatives". Journal of ... Finally, reacting this with butyl alcohol in the presence of sulfuric acid, followed by treatment with sodium hydroxide to ... In the first stage of synthesis, it undergoes sulfonylchlorination by chlorosulfonic acid, forming 4-chloro-3- ... chlorosulfonylbenzoic acid, which is further nitrated with nitric acid to 4-chloro-3-chlorosulfonyl-5-nitrobenzoic acid. ...
Acton, Q. Ashton (2013). Aminobenzoic Acids-Advances in Research and Application (2013 ed.). Atlanta: ScholarlyEditions. p. 23 ... tolfenamic acid, flufenamic acid, and meclofenamic acid are derived from fenamic acid or anthranilic acid and are called " ... Fenamic acid is a derivative of anthranilic acid,: 235 which in turn is a nitrogen isostere of salicylic acid, which is the ... Anthranilic acid is an aromatic acid with the formula C6H4(NH2)(CO2H) and has a sweetish taste. The molecule consists of a ...
... is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging ... It can be reacted with 4-aminobenzoic acid to make procaine. DEAE can be used as a precursor for DEAE-cellulose resin, which is ...
... ester of para-aminobenzoic acid as a local anaesthetic]. Klinische Wochenschrift (in German). 39: 373-375. Guénette SA, Giroux ... Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification ... In industrial practice, the reducing agent is usually iron and water in the presence of a little acid. Benzocaine was first ... Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform, and ethyl ...
27 (4): 647-50. doi:10.1016/0306-3623(95)02079-9. PMID 8853299. Blatt SL, Takahashi RN (April 1998). "Memory-impairing effects ... 58 (4): 220-8. CiteSeerX 10.1.1.327.1264. doi:10.1002/syn.20199. PMID 16206183. S2CID 15631376. TOKYO CHEMICAL INDUSTRY CO., ... When inhaled, dimethocaine starts working in 10-30 minutes, with highest effects at 60-120 minutes and until 4-6 hours there is ... 31 (4): 555-9. doi:10.1590/s0100-879x1998000400013. PMID 9698809. Greene SL (2013). "Miscellaneous Compounds". Novel ...
... obtained by coupling para-aminobenzoic acid and glycine. That product is then treated with nitrous acid to give the diazonium ... Reaction of this species with salicylic acid proceeds at the position para to the phenol to give balsalazide. "Colazide 750mg ... Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that ... See Ex 4 for Balsalazide proper. Same protocol but uses β-Alanine. Starting material is 4-aminohippuric acid, ...
Polymorphisms of NAT2 include the single amino acid substitutions R64Q, I114T, D122N, L137F, Q145P, R197Q, and G286E. These are ... of their amino acid sequence. Both also have an active site cysteine residue (Cys68) in the N-terminal region. Further, all ... Human NAT1 preferentially acetylates 4-aminobenzoic acid (PABA), 4 amino salicylic acid, sulfamethoxazole, and sulfanilamide. ...
Folates are pterins that contain p-aminobenzoic acid connected to the methyl group at position 6 of the pteridine ring system ( ... The aromatic amino acid hydroxylases include phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylases. They ... Folic acid Molybdopterin Pteridine Tetrahydrobiopterin Tetrahydromethanopterin Wijnen B, Leertouwer HL, Stavenga DG (December ... Substituted pteridines are intermediates in the biosynthesis of dihydrofolic acid in many microorganisms. The enzyme ...
Chorismate is transformed into para-aminobenzoic acid by the enzymes 4-amino-4-deoxychorismate synthase and 4-amino-4- ... 3-Dihydroxybenzoic acid (DHB) used for enterobactin biosynthesis The plant hormone salicylic acid Many alkaloids and other ... The name chorismic acid derives from a classical Greek word χωρίζω meaning "to separate", because the compound plays a role as ... Chorismic acid, more commonly known as its anionic form chorismate, is an important biochemical intermediate in plants and ...
41 (4): 400-4. PMID 8894797. Ellington J, Daughtery S. Prevalence of vaginal dryness in trying-to-conceive couples" Fertil ... Additionally, a commonly used numbing agent benzocaine can cause an allergic reaction in those with an allergy to PABA (4- ... aminobenzoic acid). Some lubricants are conveniently packaged for ease of application. Many of these products such as ... 79: 21-2. doi:10.1016/s0015-0282(03)00127-4. Steiner, AZ; Long, DL; Tanner, C; Herring, AH (Jul 2012). "Effect of vaginal ...
Method for the prepareation of p-aminobenzoic acid alkamine esters]", published 1906-12-11, assigned to Höchst A.M. ; DE 194748 ... is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which ... Method for the prepareation of p-aminobenzoic acid alkamine esters]", published 1908-01-28, assigned to Höchst A.M. , ... the resulting acid chloride is then esterified with 2-diethylaminoethanol to give Nitrocaine. Finally, the nitro group is ...
58 (4): 384-91. doi:10.1007/s12630-010-9450-x. PMID 21203878. S2CID 31870857. Gissen AJ, Datta S, Lambert D (July 1984). "The ... 59 (6): 452-4. doi:10.1213/00000539-198006000-00014. PMID 7189987. Förster JG, Kallio H, Rosenberg PH, Harilainen A, Sandelin J ... The hydrochloride salt of 4-amino-2-chlorobenzoyl chloride is made by the reaction of 2-chloro-4-aminobenzoic acid with thionyl ... 151 (3): 322-4. doi:10.1016/0002-9378(85)90295-9. PMID 3970100. Chestnut DH (2004). Obstetric Anesthesia: Principles and ...
2-Nitrobenzoic acid is prepared by oxidation of 2-nitrotoluene. 3-Nitrobenzoic acid is a precursor to 3-aminobenzoic acid, ... Nitrobenzoic acid[which?] can be prepared through the oxidation of styrene in boiling nitric acid. The salts and esters of ... Nitrobenzoic acids are derivatives of benzoic acid. Two are commercially important. They are about ten times more acidic than ... It can be prepared by nitration of benzoic acid. It also can be prepared by treating benzaldehyde under nitration conditions, a ...
Shikimic acid Davies GM, Barrett-Bee KJ, Jude DA, Lehan M, Nichols WW, Pinder PE, Thain JL, Watkins WJ, Wilson RG (1994). "(6S ... 6S)-6-Fluoroshikimic acid is an antibacterial agent acting on the aromatic biosynthetic pathway. It may be used against ... 6-Fluoro-Shikimic Acid". Antimicrobial Agents and Chemotherapy. 39 (1): 87-93. doi:10.1128/AAC.39.1.87. PMC 162490. PMID ... 6-Fluoroshikimic Acid, an Antibacterial Agent Acting on the Aromatic Biosynthetic Pathway". Antimicrobial Agents and ...
... yellowish water-insoluble oily liquid is an ester formed by the condensation of 2-ethylhexanol with dimethylaminobenzoic acid. ... 35 (4): 546-9. doi:10.1016/S0190-9622(96)90677-5. PMID 8859281. Kerr, Caroline (1998). "The effects of two UVB radiation- ... 9 (3-4): 323-334. doi:10.1016/1011-1344(91)80169-I. PMID 1919875. Bissett, Donald L; McBride, James F (1996). "Synergistic ... Padimate O is an organic compound related to the water-soluble compound PABA (4-aminobenzoic acid) that is used as an ...
"Laser-Induced Acoustic Desorption/Electron Ionization of Amino Acids and Small Peptides". Journal of the American Society for ... 2 (4): 350-353. 1991-08-01. doi:10.1016/1044-0305(91)80027-5. ISSN 1044-0305. "News and Views" (PDF). American Society for Mass ... 4 (4): 2316-2322. doi:10.1021/acssuschemeng.5b01776. ISSN 2168-0485. Fingas, Merv, ed. (2022-05-23). The Chemistry of Oil and ... 4 (2): 806-813. doi:10.1039/C2SC21657D. ISSN 2041-6520. Parsell, Trenton; Yohe, Sara; Degenstein, John; Jarrell, Tiffany; Klein ...
pK, ΔHo, and ΔSo values for proton ionization from o-, m-, and p-Aminobenzoic Acids and their methyl esters at 25 °C. J. Phys. ... nucleic acid chemistry, metal cyanide chemistry, chemical separations, amino acid microspecies formation, and high- temperature ... Izatt, R. et al Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, ... deoxyribonucleic acid, and their constituent bases, nucleosides, and nucleotides. Chem. Rev. 1971 vol 71 pp439-481. Oscarson, J ...
Other metabolites of procainamide include desethyl-N-acetylprocainamide, desethylprocainamide, p-aminobenzoic acid, which are ... These are aromatic carboxylic acid derivatives consisting of an amide with a benzamide moiety and a triethylamine attached to ... N-acetyl-4-aminobenzoic acid as well as N-acetyl-3-hydroxyprocainamide, N-acetylprocainamide-N-oxide and N-acetyl-4- ... aminohippuric acid are also metabolites of procainamide. 4-amino-N-2-(diethylamino)ethyl-benzamide (also known as para-amino-N- ...
... p-aminobenzoic acid or para-aminobenzoic acid) 3-Aminobenzoic acid (m-aminobenzoic acid or meta-aminobenzoic acid) 2- ... aminobenzoic acid (o-aminobenzoic acid or ortho-aminobenzoic acid, Anthranilic acid) This set index article lists chemical ... Aminobenzoic acid (a benzoic acid with an amino group) can refer to: 4-Aminobenzoic acid ( ...
... including acids such as acetic acid or bases such as pyridine and an excellent solvent for organic substances such as ε- ... caprolactam or benzoic acid and dissolves even some inorganic salts such as silver nitrate or sodium iodide. Due to its ... such as isophthalic acid) and aromatic diamines (such as 1,3-diaminobenzene (m-phenylenediamine)) to aramids such as poly (m- ... A modification of the Koenigs-Knorr reaction for building glycosides from 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide ( ...
... ic acid.) Most natural amino acids are α-amino acids in the L conformation, but some exceptions exist. Some non-α-amino acids ... Chemically synthesized amino acids can be called unnatural amino acids. Unnatural amino acids can be synthetically prepared ... Whereas glutamic acid possess one γ-carboxyl group, Carboxyglutamic acid possess two. Hydroxyproline. This imino acid differs ... and a carboxylic acid (-COOH) functional group is an amino acid. The proteinogenic amino acids are small subset of this group ...
34 (4): 1002-1013. doi:10.1002/hlca.19510340404. S. M. McElvain and T. P. Carney, J. Amer. Chem. Soc, 68, 2592 (1946). K. ... 4-Aminobenzoic acid Amino amide Amino esters Anesthesia Anesthetic Brachial plexus block Cocaine analogues: local anesthetics ... Soc, 61, 1713 (1939). Clinton, R. O.; Salvador, U. J.; Laskowski, S. C.; Wilson, Mary (February 1952). "Derivatives of 4-Amino- ... 2-hydroxybenzoic Acid. II". Journal of the American Chemical Society. 74 (3): 592-598. doi:10.1021/ja01123a005. N. Lofgren, C. ...
... also known as para-aminobenzoic acid or PABA, an organic compound Barter Island LRRS Airport (ICAO: PABA) Paba Upazila, ... the governing body of baseball in the Philippines 4-Aminobenzoic acid, ...
"Para-aminobenzoic acid". Medline Plus Medical Encyclopedia. United States National Institutes of Health. Retrieved 24 January ... Toxicity, Local Anesthetics: eMedicine Emergency Medicine "Aminobenzoic acid". Drug Information Portal. U.S. National Library ... "Synthesis of para-Amino Benzoic Acid-TiO2 Hybrid Nanostructures of Controlled Functionality by an Aqueous One-Step Process". ... "Synthesis of para-Amino Benzoic Acid-TiO2 Hybrid Nanostructures of Controlled Functionality by an Aqueous One-Step Process". ...
... nitrophthalic acids and derivatives, pyridine derivatives, chiral compounds and several miscellaneous APIs. ... You can now view 4-Aminobenzoic acid (PABA) here in addition to all other active pharmaceutical ingredients, including ... also known as para-aminobenzoic acid or PABA because the two functional groups are attached to the benzene ring across from one ...
... amino]benzoic acid Molecular Formula: C15H14N3O4+ ... amino]benzoic acid Registries: PubChem CID 3619262 PubChem ID ... InChI: InChI=1/C15H13N3O4/c16-14(20)11-2-1-7-18(8-11)9-13(19)17-12-5-3-10(4-6-12)15(21)22/h1-8H,9H2,(H3-,16,17,19,20,21,22)/p+1 ...
... benzoic acid , C28H22N2O4 , CID 1381899 - structure, chemical names, physical and chemical properties, classification, patents ...
Click the button below to add the 4-Aminobenzoic acid sodium salt 25 g to your wish list. ...
Aminobenzoic acids their derivatives are important for the preparation of other pharmaceutical products, dyes, flavors, and ... It is a starting material in the manufacture of target esters, salts, folic acid, azo dyes and other organic compounds. It is ... This compound is a part of folic acid molecule and was called Vitamin BX as it is a component of pteroylglutamate. ... Aminobenzoic acids their derivatives are important for the preparation of other pharmaceutical products, dyes, flavors, and ...
... nitrophthalic acids and derivatives, pyridine derivatives, chiral compounds and several miscellaneous APIs. ... You can now view 4-Aminobenzoic acid (PABA) here in addition to all other active pharmaceutical ingredients, including ... also known as para-aminobenzoic acid or PABA because the two functional groups are attached to the benzene ring across from one ...
Para-aminobenzoic acid (PABA) is a natural substance. It is often used in sunscreen products. PABA is sometimes called vitamin ... Para-aminobenzoic acid (PABA) is a natural substance. It is often used in sunscreen products. PABA is sometimes called vitamin ... Para-aminobenzoic acid (PABA) is a natural substance. It is often used in sunscreen products. PABA is sometimes called vitamin ... Para-aminobenzoic acid (also known as 4-aminobenzoic acid) can be harmful in large amounts. ...
"Treatment of scleroderma with para-aminobenzoic acid: effect on disease morbidity." Study Citation. Sawalha, K. Treatment of ... Other alternative symptomatic therapy including Para-aminobenzoic acid decreases the progression of skin fibrosis and improves ... scleroderma with para-aminobenzoic acid: effect on disease morbidity. Arch Gen Intern Med. 2018; 2 (3): 19-22. DOI: 10.4066/ ...
4-quinolinyl]amino}benzoic acid (C17H11F3N2O2) from the PQR. ... amino)benzoic acid. *2-[[7-(trifluoromethyl)quinolin-4-yl]amino ...
Be the first to review "4-AMINOBENZOIC ACID-UNILAB-886-250GR" Cancel reply. Your email address will not be published. Required ... 4-AMINOBENZOIC ACID-UNILAB-886-250GR. Home/Chemicals/4-AMINOBENZOIC ACID-UNILAB-886-250GR ...
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Benzoic Acid 1 g Price and Buy 2-[(4-Chloro-2-Nitrophenyl)Amino]Benzoic Acid Online in India from Carbanio. Carbanio is Indias ... Benzoic Acid. Order and get 2-[(4-Chloro-2-Nitrophenyl)Amino]Benzoic Acid delivered to your doorstep in India. ... trusted Chemical Shop to buy 2-[(4-Chloro-2-Nitrophenyl)Amino] ... Amino]Benzoic Acid price and Order to get it delivered to your ... Amino]Benzoic Acid 1 g Online from Carbanio. Carbanio is Indias trusted Chemical Shop to buy 2-[(4-Chloro-2-Nitrophenyl)Amino] ...
PABA may alter thyroid activity[1],[2],[3] and PABA derivatives may have additional endocrine disrupting properties.[4],[5],[6] ... "The sensitizing effect of a sunscreening agent, p-aminobenzoic acid, on near UV induced damage in a repair deficient strain of ... "The sensitizing effect of a sunscreening agent, p-aminobenzoic acid on near UV induced damage in a repair deficient strain of ... "Photoaddition of p-aminobenzoic acid to thymine and thymidine." Photochem Photobiol. 1992 May;55(5):657-63. Print. ...
AMINO}BENZOIC ACID. Find entries where: ZZL. is present as a standalone ligand in 4 entries ... Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. , PMID:21059682 ... 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID. ... 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid. ...
They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved ... It is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen. it is ... The absorption of DEAE (administered orally as DEAE acid malate or Cerebrol) in healthy adult rats is very rapid, reaching a ... Diethylaminoethanol can react with strong oxidizers and acids.. Health Hazard. INHALATION: Irritation of mucous membranes. EYES ...
EDQM Strasbourg, France 03/04/2020 Diminuer la taille du texte Augmenter la taille du texte Imprimer la page Imprimer en PDF New releases: Replacement batches for Ph. Eur. reference standards...
P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE AT PH 7.4 ... 2 x PAB: 4-AMINOBENZOIC ACID(Non-covalent). PAB.2: 15 residues within 4Å:*. Chain A: R.44, G.46, V.47, W.185, L.199, Y.201, L. ... PAB.4: 15 residues within 4Å:*. Chain B: R.44, G.46, V.47, W.185, L.199, Y.201, L.210, S.212, R.214, R.220, Y.222, P.293, T.294 ... P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE AT PH 7.4 Coordinates. PDB Format Method. X-RAY DIFFRACTION 2.00 Å ...
Categories: 4-Aminobenzoic Acid Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted ...
11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans. Alvaro A. Ordonez,1,2 ... 11C]Para-aminobenzoic acid: a positron emission tomography tracer targeting bacteria-specific metabolism. ACS Infect Dis. 2018; ... The use of p-aminobenzoic acid as a probe substance for the targeted profiling of glycine conjugation. J Biochem Mol Toxicol. ... Para-aminobenzoic acid used as a marker for completeness of 24 hour urine: assessment of control limits for a specific HPLC ...
... amino]benzoic acid Molecular Formula: C13H7ClN4O5 ... benzoic acid Registries: PubChem CID 2836593 PubChem ID 3312005 ... InChI: InChI=1/C13H7ClN4O5/c14-7-5-9(12(18(21)22)11-10(7)16-23-17-11)15-8-4-2-1-3-6(8)13(19)20/h1-5,15H,(H,19,20)/f/h19H ... 2-[(5-chloro-2-nitro-8-oxa-7,9-diazabicyclo[4.3.0]nona-2,4,6,9-tetraen-3-yl)amino] ... 2-[(5-chloro-2-nitro-8-oxa-7,9-diazabicyclo[4.3.0]nona-2,4,6,9-tetraen-3-yl) ...
Anthranilic Acid. 2-Aminobenzoic acid. ME545052. -. C00108. -. -. Arabitol/Xylitol. Arabitol. ME545071. -. C01904. -. - ... Indole-3-Acetic Acid. Indoleacetic acid. ME545103. -. C00954. -. -. Indole-3-Carboxylic Acid. Indole-3-carboxylic acid. ... 3-Hydroxycinnaminic Acid. cis-p-Coumaric acid. ME545087. -. C00811. -. -. 3-Hydroxyisovaleric Acid. 3-Hydroxyisovaleric acid. ... 2-isoPropylmalic Acid. 2-Isopropylmalic acid. ME545107. -. C02504. -. -. 2-Methylglutaric Acid. 2-Methylglutaric acid. ME545059 ...
Abbreviations: AA, ascorbic acid; AA-P, ascorbic acid 2-phosphate; ACTP, apoferritin templated cadmium phosphates; AFP, alpha ... tryptophan and caffeic acid-based resin microspheres; TB, toluidine blue; THI, thionine; UA, uric acid; VFc-ATP, vinyl ... as well as liposomes with encapsulated ascorbic acid (AA) and uric acid (AU) for monitoring neuron-specific enolase (NSE) and ... Prussian Blue (PB) [33,34,35], toluidine blue (TB) [33], ferrocene [34,36,37] or ferrocene carboxylic acid (Fca) [6,38] , ...
Carboxylic Acid Esters [Non-Heterocyclic Building Blocks] Esters_C10 [Non-Heterocyclic Building Blocks] ... It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 ( ... Please input only the 4-5 alphanumeric characters before the hyphen. Search. Please check that the lot number you have entered ... Please input only the 4-5 alphanumeric characters before the hyphen. Search. The requested analytical chart is not available. ...
Medicinal Ingredients: 4-Aminobenzoic acid, ethyl ester 15.0 mg, l-Menthol 3.6mg. Non-Medicinal Ingredients: Cherry flavour, D& ...
... benzoic acid); ≥ 98% HPLC; This compound is a featured product for Cyclic Nucleotide research; BC8-15 is a potent PDE4/8 ... amino]-benzoic acid. Empirical Formula (Hill Notation). : C18H15N5O2 ... 1S/C18H15N5O2/c1-2-15-21-22-16-13-8-3-4-9-14(13)20-18(23(15)16)19-12-7-5-6-11(10-12)17(24)25/h3-10H,2H2,1H3,(H,19,20)(H,24,25) ...
... amino}benzoic acid. C27 H26 F3 N3 O4. OQQHKPTYNRWLGC-UHFFFAOYSA-N. Interactions *Focus chain C [auth A] ...
2-aminobenzoic acid methyl ester. aminobifenox. Sediment; Animal (faeces). -. -. ... 5-hydroxybifenox acid. Plant. -. -. 5-(2,4-dichloro-?-hydroxy-phenoxy)-2-nitrobenzoic acid (Ref: LS-825055). hydroxybifenox ... 1-4. A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III ... Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242. ...
... aminobenzoic acid sodium salt; Sodium N-(+)-biotinyl-4-aminobenzoate Empirical Formula: C17H20N3NaO4S Linear Formula: …. ... certified by the Biological Stain Commission, Dye content 70 % Synonym(s): Acid Magenta; Acid Rubin; Fuchsin S, SS, SS, ST, or ... hexenoic acid; 4-Hexenoic acid; 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]- Empirical Formula: C22H ... purum, ≥99.0% (GC) Empirical Formula: C10H10O4 Formula Weight: 194.18 Linear Formula: C6H4-1,4-(CO2CH3)2 MDL Number: ...
  • 4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the two functional groups are attached to the benzene ring across from one another in the para position) is an organic compound with the formula H2NC6H4CO2H. (wikipedia.org)
  • In industry, PABA is prepared mainly by two routes: Reduction of 4-nitrobenzoic acid Hoffman degradation of the monoamide derived from terephthalic acid. (wikipedia.org)
  • Many bacteria, including those found in the human intestinal tract such as E. coli, generate PABA from chorismate by the combined action of the enzymes 4-amino-4-deoxychorismate synthase and 4-amino-4-deoxychorismate lyase. (wikipedia.org)
  • Para-aminobenzoic acid (PABA) is a natural substance. (medlineplus.gov)
  • Para-aminobenzoic acid (PABA) is a chemical found in the folic acid vitamin and also in several foods including grains, eggs, milk, and meat. (nanochemia.ir)
  • Hydrolysis of amino ester compounds yields para -aminobenzoic acid (PABA), a well-known allergen, as an intermediate metabolite. (medscape.com)
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  • Aminobenzoic acids their derivatives are important for the preparation of other pharmaceutical products, dyes, flavors, and preservatives. (plantmedia.com)
  • Click the button below to add the 4-Aminobenzoic acid sodium salt 25 g to your wish list. (p212121.com)
  • MULTI STAR is an ionized micro-colloidal solution of basic minerals, trace elements, vitamins, enzymes, antioxidants and amino acids. (apothecium.eu)
  • This compound is a part of folic acid molecule and was called Vitamin BX as it is a component of pteroylglutamate. (plantmedia.com)
  • It is a starting material in the manufacture of target esters, salts, folic acid, azo dyes and other organic compounds. (plantmedia.com)
  • Vitamin B12 deficiency (eg, pernicious anemia), folic acid deficiency, and certain medications are the most common causes of megaloblastic anemia, a macrocytic anemia. (medscape.com)
  • Vitamin B-12 and folic acid deficiencies and certain medications are the most common causes of megaloblastic anemia, a macrocytic anemia. (medscape.com)
  • UNC 1215, acid contains a carboxylic acid handle ready for conjugation to a target protein ligand. (tocris.com)
  • Soluble in glacial acetic acid, chloroform and ethyl acetate. (plantmedia.com)
  • Kinetic constants determined for the expressed enzymes with 2-aminofluorene and p-aminobenzoic acid indicated that Km values were not significantly different between the enzymes, although the Vmax value of NAT-2(99asn) was consistently 2-3-fold higher than that of NAT-1 or NAT-2(99ile). (cdc.gov)
  • Amino acid residues LYS791, MET793, ARG841, ARG842, and LEU844 were involved in active site binding and played a crucial role in inhibiting cAMP-dependent protein kinase. (bvsalud.org)
  • the properties of permeability and also the organic composition of its substrate 4-7 . (bvsalud.org)
  • isoniazid was a preferred substrate for NAT-1, whereas p-aminobenzoic acid was preferred for NAT-2(99asn) and NAT-2(99ile). (cdc.gov)
  • The major challenge of these systems lies in providing appropriate bonding to the different tissues as these have very different compositions 4-5 . (bvsalud.org)
  • Treatment of scleroderma with para-aminobenzoic acid: effect on disease morbidity. (sentinelvitamins.com)
  • The sensitizing effect of a sunscreening agent, p-aminobenzoic acid, on near UV induced damage in a repair deficient strain of Escherichia coli. (safecosmetics.org)
  • It is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen. (lookchem.com)
  • Be the first to review UNC 1215, acid and earn rewards! (tocris.com)
  • Incompatible with strong oxidizing agents, acids. (lookchem.com)