(1/255) N-acetylation of the heterocyclic amine batracylin by human liver.

Batracylin (8-aminoisoindolo[1,2-b]quinazolin-12(10 H)-one; BAT) is a heterocyclic amine that exhibits antitumor activity in a number of in vivo and in vitro models. The acetyl product has been implicated in BAT toxicity in animals, cells, and bacteria. The ability of human N-acetyltransferase (NAT) to form this product was investigated. Nine human liver samples were analyzed for NAT1 and NAT2 genotypes. Seven of the samples possessed at least one NAT1*4 allele. Three samples contained one or more NAT2*4 allele and were classified as rapid acetylators. The remaining six had two alleles associated with the slow phenotype. NAT activities were evaluated with BAT, sulfamethazine (SMZ), a preferential substrate for human NAT2, and p-aminobenzoic acid, a substrate for NAT1. BAT activities in the nine donor samples ranged from 14.9 to 0.56 nmol/min/mg. The mean apparent K(m) values in rapid acetylators for BAT, SMZ, and p-aminobenzoic acid were 6.59 +/- 3.21, 278 +/- 69.4, and 31.2 +/- 12.5 microM, respectively. The apparent K(m) values for slow acetylators did not differ from the rapid acetylator phenotype. However, a significant difference in the apparent V(max) for BAT and SMZ was observed between rapid and slow acetylators. Comparing the apparent intrinsic clearance (V(max)/K(m)) for BAT and SMZ, a significant correlation (r(2) = 0.97, p <.001) was observed. These data demonstrate that BAT N-acetylation is similar to SMZ, and suggests that BAT is a preferential substrate for human NAT2. Thus, rapid acetylators would be more likely to develop toxicity when exposed to this drug.  (+info)

(2/255) Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell.

The localization of 5-hydroxytryptamine(4) (5-HT(4)) receptors suggests their role in the regulation of dopamine (DA) neurotransmission, a speculation that has been supported by neurochemical studies. Mesolimbic DA systems play a prominent role in mediating the behavioral effects of the abused psychostimulant cocaine, and the intent of the present study was to assess the role of 5-HT(4) receptors in the control of spontaneous and cocaine-induced activity. Systemic administration of the 5-HT(4) receptor partial agonist 1-(4-amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]1-propa none hydrochloride (RS 67333; 0.0001-1 mg/kg) or the 5-HT(4) receptor antagonist 4-amino-5-chloro-2-methoxy-benzoic acid-(diethylamino)ethyl ester hydrochloride (SDZ 205,557; 0.0001-1 mg/kg) did not significantly alter spontaneous activity, whereas SDZ 205,557 significantly attenuated cocaine-induced horizontal activity and rearing. To test the hypothesis that cocaine-elicited behaviors were modulated by 5-HT(4) receptors in the nucleus accumbens (NAc) shell, two separate groups of male rats were implanted with bilateral cannulas aimed at the NAc shell. Intra-NAc shell microinjections of either RS 67333 (1 or 3 microgram/0.2 microliter/side) or SDZ 205,557 (1-5 microgram/0.2 microliter/side) did not alter spontaneous activity observed after a systemic saline injection but did significantly attenuate the hyperactivity induced by systemic cocaine injection (10 mg/kg). These results support an involvement of 5-HT(4) receptors, particularly those in the NAc shell, in the locomotor stimulatory effects of cocaine. Furthermore, these data suggest that 5-HT(4) receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.  (+info)

(3/255) Increased levels of dihydrofolate reductase in rifampin-resistant mutants of Bacillus subtilis.

Several independent, spontaneous rifampin-resistant mutants of Bacillus subtilis were isolated and found to have an increased resistance to trimethoprim, an inhibitor of dihydrofolate reductase. This increased resistance in the rif mutants was the result of a specific threefold increase in the activity of dihydrofolate reductase, since six other enzymes examined remained unchanged. This increased level of dihydrofolate reductase and the trimethoprim resistance were cotransformed (100%) with the rif marker. These results suggest that the RNA polymerase is altered in its recognition of the gene that specifies dihydrofolate reductase.  (+info)

(4/255) N-Acetylation of paraphenylenediamine in human skin and keratinocytes.

Skin is the major target of allergic reactions to paraphenylenediamine (PPD). Such small molecules require activation to become immunogenic. The balance between activation and/or detoxification processes is critical for immunogenic potentials of compounds. Therefore, we investigated N-acetylation (NAT) capacities of human skin for PPD to gain a better understanding of its mechanisms of action. PPD is acetylated to monoacetyl-PPD (MAPPD), which in turn is acetylated to N,N'-diacetyl-PPD (DAPPD). This was found using cytosolic fractions from human skin (n = 9) and cultured normal human epidermal keratinocytes (n = 7). The cutaneous activities for MAPPD formation ranged from 0.41 to 3.68 nmol/mg/min (9-fold variation) and DAPPD formation from 0.65 to 3.25 nmol/mg protein/min (5-fold), respectively. Similar results were obtained with keratinocytes. NAT activities toward both substrates, PPD and MAPPD, were correlated in keratinocytes (r = 0.930), suggesting that the reactions were catalyzed by the same enzyme. Formation of MAPPD and DAPPD was competitively inhibited in the presence of p-aminobenzoic acid (300 microM), a typical NAT1 substrate, but not by sulfamethazine. These kinetic characteristics suggest that the acetylation of PPD in human skin and keratinocytes is predominantly attributable to the polymorphic NAT1, although both mRNAs (NAT1 and NAT2) are synthesized in human skin and keratinocytes. The metabolism of PPD by NAT1 in human skin and keratinocytes as well as the virtual absence of NAT2 activity may have important toxicological implications. In the case of PPD, our results emphasize that N-acetylation status may be a susceptibility factor for the development of an allergy to PPD.  (+info)

(5/255) Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells.

Arylamine N-acetyltransferase-1 (NAT1) is a polymorphically expressed enzyme that is widely distributed throughout the body. In the present study, we provide evidence for substrate-dependent regulation of this enzyme. Human peripheral blood mononuclear cells cultured in medium supplemented with p-aminobenzoic acid (PABA; 6 microM) for 24 h showed a significant decrease (50-80%) in NAT1 activity. The loss of activity was concentration-dependent (EC(50) approximately 2 microM) and selective because PABA had no effect on the activity of constitutively expressed lactate dehydrogenase or aspartate aminotransferase. PABA also induced down-regulation of NAT1 activity in several human cell lines grown at confluence. Substrate-dependent down-regulation was not restricted to PABA. Addition of other NAT1 substrates, such as p-aminosalicylic acid, ethyl-p-aminobenzoate, or p-aminophenol to peripheral blood mononuclear cells in culture also resulted in significant (P <.05) decreases in NAT1 activity. However, addition of the NAT2-selective substrates sulfamethazine, dapsone, or procainamide did not alter NAT1 activity. Western blot analysis using a NAT1-specific antibody showed that the loss of NAT1 activity was associated with a parallel reduction in the amount of NAT1 protein (r(2) = 0.95). Arylamines that did not decrease NAT1 activity did not alter NAT1 protein levels. Semiquantitative reverse transcriptase polymerase chain reaction of mRNA isolated from treated and untreated cells revealed no effect of PABA on NAT1 mRNA levels. We conclude that NAT1 can be down-regulated by arylamines that are themselves NAT1 substrates. Because NAT1 is involved in the detoxification/activation of various drugs and carcinogens, substrate-dependent regulation may have important consequences with regard to drug toxicity and cancer risk.  (+info)

(6/255) Sensitive and selective determination of tetracaine and its metabolite in human samples by gas chromatography-mass spectrometry.

A sensitive and reliable method was developed for the determination of tetracaine and its metabolite, p-butylaminobenzoic acid, in human samples. Tetracaine and the metabolite, effectively extracted using a liquid-liquid extraction procedure from 0.5 g of sample, were analyzed by gas chromatography-mass spectrometry. Tetracaine was analyzed without derivatization, and the metabolite was analyzed after tert-butylolimethylsilyl derivatization. Dibucaine and p-dimethylaminobenzoic acid were used as internal standards for tetracaine and the metabolite, respectively. The calibration curve for each compound was linear in the concentration range from 10 to 1,000 ng/0.5 g, and the lower limits of detection were 10 ng/g for tetracaine and 0.6 ng/g for the metabolite in whole blood and tissues. The accuracy and precision of the method were evaluated in whole blood and brain at the concentrations of 50 ng/0.5 g and 500 ng/0.5 g for tetracaine and 10 ng/0.5 g and 100 ng/0.5 g for the metabolite. The coefficients of variation ranged from 0.8 to 3.0% for tetracaine and 2.4 to 9.8% for the metabolite. We used this method to determine tetracaine and its metabolite in human whole blood and tissues of an autopsied patient who died during spinal anesthesia induced by tetracaine.  (+info)

(7/255) Inhibition of the development of the cellular slime mould Dictyostelium discoideum by omega-aminocarboxylic acids.

Four omega-aminocarboxylic acids - epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexane-1-carboxylic acid (t-AMCHA), p-aminomethylbenzoic acid (PAMBA) and omega-aminocaprylic acid (OACA) -- prevented fruiting body formation of the cellular slime mould Dictyostelium discoideum. At concentrations of 40 mM, 75 mM, 10 mM and 5 mM, respectively, they allowed aggregation but prevented all further development at 24 degrees C. At lower concentrations, EACA allowed fruiting body formation but with a reduced number of spores per fruiting body. Only t-AMCHA had a significant inhibitory effect on the growth of myxamoebae. EACA affected development only if it was present between 8 and 16 h after the cells were deposited on the filters. Its effect was enhanced by high salt concentrations and by higher temperature, and was also dependent on the manner in which the cells were grown. Only strains capable of axenic growth displayed this sensitivity to EACA, although strains carrying only one of the genetic markers for axenic growth (axe A) were partially sensitive.  (+info)

(8/255) The effect of epsilon-aminocaproic acid on biochemical changes in the development of the cellular slime mould Dictyostelium discoideum.

epsilon-Aminocaproic acid (EACA) inhibited the development of Dictyostelium discoideum strain AX2 after the aggregation stage. Biochemical changes that occurred early in development (loss of cellular protein, RNA and carbohydrate; increase in the specific activity of N-acetylglucosaminidase, alpha-mannosidase, threonine deaminase and leucine aminopeptidase) were not affected by concentrations of EACA which blocked development; but biochemical changes that occurred later (synthesis of carbohydrate, increase in the specific activity of UDP-glucose pyrophosphorylase) were inhibited. Spores from fruiting bodies formed in the presence of low concentrations of EACA were larger, more spherical and less able to survive heat treatment than spores from fruiting bodies of control (no EACA) cells.  (+info)

*  4-Aminobenzoic acid
Nutritional Health Resource "Para-aminobenzoic acid". Medline Plus Medical Encyclopedia. United States National Institutes of ... Toxicity, Local Anesthetics: eMedicine Emergency Medicine Para-Aminobenzoic acid MS Spectrum PABA Cancer link. ... also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position ... "The Sensitization of Near-Ultraviolet Radiation Killing of Mammalian Cells by the Sunscreen Agent Para-aminobenzoic Acid". ...
*  Protomer
Examples in chemistry include Tyrosine and 4-aminobenzoic acid. The former may be deprotonated to form the carboxylate and ...
*  4-Nitrobenzoic acid
"Safety data for p-nitrobenzoic acid". Retrieved 11 April 2010. "p-Nitrobenzoic acid". Archived from the original on 7 May 2010 ... O. Kamm and A. O. Matthews "p-Nitrobenzoic Acid" Org. Synth. 1922, volume 2, p. 53. doi:10.15227/orgsyn.002.0053 "Material ... "Dissociation Constants Of Organic Acids And Bases". Retrieved 11 April 2010. "Bordwell pKa Table (Acidity in DMSO)". Retrieved ... Takao Maki, Kazuo Takeda "Benzoic Acid and Derivatives" in Ullmann's Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, ...
*  Aminomethylbenzoic acid
... (more precisely, 4-aminomethylbenzoic acid or p-aminomethylbenzoic acid, PAMBA) is an antifibrinolytic ...
*  Myeloperoxidase
Hypochlorous acid and tyrosyl radical are cytotoxic, so they are used by the neutrophil to kill bacteria and other pathogens. ... However, this hypochlorous acid may also cause oxidative damage in host tissue. Moreover, MPO oxidation of apoA-I reduces HDL- ... MPO is a member of the XPO subfamily of peroxidases and produces hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and ... MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to ...
*  Butamben
that is mildy soluble in water (1 part in 7000) and soluble in alcohol, ether, chloroform, fixed oils, and dilute acids. It ... It is the ester of 4-aminobenzoic acid and butanol. A white, odourless, crystalline powder. ...
*  Diethylethanolamine
... is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging ... It can be reacted with 4-aminobenzoic acid to make procaine. DEAE can be used as a precursor for DEAE-cellulose resin, which is ...
*  Benzocaine
... is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification ... ester of para-aminobenzoic acid as a local anaesthetic), Klinische Wochenschrift, vol. 39, pages 373-375. Guénette, SA; Giroux ... In industrial practice, the reducing agent is usually iron and water in the presence of a little acid. Benzocaine was first ... Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform, and ethyl ...
*  Pteridine
... is a precursor in the synthesis of dihydrofolic acid in many microorganisms. The enzyme dihydropteroate synthetase ... converts pteridine and 4-aminobenzoic acid to dihydrofolic acid in the presence of glutamate. The enzyme dihydropteroate ...
*  Procaine
... is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which ... the resulting acid chloride is then esterified with 2-diethylaminoethanol to give Nitrocaine. Finally, the nitro group is ... The first consists of the direct reaction of the 4-aminobenzoic acid ethyl ester with 2-diethylaminoethanol in the presence of ... Retrieved 4 September 2015. Einhorn, A.; Fiedler, K.; Ladisch, C.; Uhlfelder, E. (1909). "Ueber p-Aminobenzoësäurealkaminester ...
*  6S)-6-Fluoroshikimic acid
Shikimic acid Davies GM, Barrett-Bee KJ, Jude DA, Lehan M, Nichols WW, Pinder PE, Thain JL, Watkins WJ, Wilson RG (1994). "(6S ... 6S)-6-Fluoroshikimic acid is an antibacterial agent acting on the aromatic biosynthetic pathway. It may be used against ... 6-Fluoro-Shikimic Acid" (pdf). Antimicrobial Agents and Chemotherapy. 39 (1): 87-93. doi:10.1128/AAC.39.1.87. PMC 162490 . PMID ... 6-Fluoroshikimic Acid, an Antibacterial Agent Acting on the Aromatic Biosynthetic Pathway" (pdf). Antimicrobial Agents and ...
*  Padimate O
... yellowish water-insoluble oily liquid is an ester formed by the condensation of 2-ethylhexanol with dimethylaminobenzoic acid. ... 35 (4): 546-9. doi:10.1016/S0190-9622(96)90677-5. PMID 8859281. Kerr, Caroline (1998). "The effects of two UVB radiation- ... 9 (3-4): 323-334. doi:10.1016/1011-1344(91)80169-I. Bissett, Donald L; McBride, James F (1996). "Synergistic topical ... Padimate O is an organic compound related to the water-soluble compound PABA (4-aminobenzoic acid) that is used as an ...
*  Chloroprocaine
1985 Feb 1;151(3):322-4. Chestnut: Obstetric Anesthesia, 3rd ed, p333. Hughes: Anesthesia for Obstetrics, 4th ed, p75.. ... The hydrochloride salt of 4-amino-2-chlorobenzoyl chloride is made by the reaction of 2-chloro-4-aminobenzoic acid with thionyl ...
*  Bentiromide
The resulting L-amide is selectively hydrolyzed by sequential use of dimsyl sodium (NaDMSO) and dilute acid to give bentiromide ... The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting ... 4 H_bond_acceptor=5 Synthetic chymotrypsin-labile peptide, used in diagnosis of exocrine pancreatic disease. It is synthesized ... 4). Chronic pancreatitis Bentiromide - Compound Summary, PubChem. P. L. De Benneville, N. J. Greenberger, DE 2156835 ; eidem, U ...
*  Reed McNeil Izatt
pK, ΔHo, and ΔSo values for proton ionization from o-, m-, and p-Aminobenzoic Acids and their methyl esters at 25 oC. J. Phys. ... nucleic acid chemistry, metal cyanide chemistry, chemical separations, amino acid microspecies formation, and high- temperature ... Izatt, R. et al Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, ... deoxyribonucleic acid, and their constituent bases, nucleosides, and nucleotides. Chem. Rev. 1971 vol 71 pp439-481. Oscarson, J ...
*  3-Aminobenzoic acid
... (also known as meta-aminobenzoic acid or MABA) is an organic compound with the molecular formula ... It consists of a benzene ring substituted with an amino group and a carboxylic acid. Aminomethylbenzoic acid Anthranilic acid 4 ... Aminobenzoic acid Arene substitution pattern Non-proteinogenic amino acids m-Carboxyaniline - Compound Summary, PubChem. 3- ...
*  Procainamide
Other metabolites of procainamide include desethyl-N-acetylprocainamide, desethylprocainamide, p-aminobenzoic acid, which are ... These are aromatic carboxylic acid derivatives consisting of an amide with a benzamide moiety and a triethylamine attached to ... N-acetyl-4-aminobenzoic acid as well as N-acetyl-3-hydroxyprocainamide, N-acetylprocainamide-N-oxide and N-acetyl-4- ... aminohippuric acid are also metabolites of procainamide. 4-amino-N-2-(diethylamino)ethyl-benzamide (also known as para-amino-N- ...
*  List of local anesthetics
34 (4): 1002-1013. doi:10.1002/hlca.19510340404. S. M. McElvain and T. P. Carney, J. Amer. Chem. Soc, 68, 2592 (1946). K. ... 4-Aminobenzoic acid Amino amide Amino esters Anesthesia Anesthetic Brachial plexus block Cocaine analogues: local anesthetics ... Soc, 61, 1713 (1939). Clinton, R. O.; Salvador, U. J.; Laskowski, S. C.; Wilson, Mary (February 1952). "Derivatives of 4-Amino- ... 2-hydroxybenzoic Acid. II". Journal of the American Chemical Society. 74 (3): 592-598. doi:10.1021/ja01123a005. N. Lofgren, C. ...
*  PABA
... also known as para-aminobenzoic acid or PABA, an organic compound Barter Island LRRS Airport (ICAO: PABA). ... the governing body of baseball in the Philippines 4-Aminobenzoic acid, ...
*  Desulfobulbus propionicus
Widdel, F.; Pfenning, N. (1982). "Studies on Dissimilatory Sulfate-Reducing Bacteria that Decompose Fatty Acids II. Incomplete ... 131 (4): 360-365. doi:10.1007/BF00411187. Lovely, Derek R.; Phillips, Elizabeth J. P. (1994). "Novel processes for anae- robic ... 63 (4): 355-362. doi:10.1002/maco.201005883. ISSN 0947-5117. Kremer, D.R.; Hansen, T.A. (1988). "Pathway of propionate ... Desulfobulbus propionicus strains 1pr3T and 3pr10 can only grow in defined minimal media with the addition of a vitamin 4- ...
*  Tetramethylurea
... including acids such as acetic acid or bases such as pyridine and an excellent solvent for organic substances such as ε- ... caprolactam or benzoic acid and dissolves even some inorganic salts such as silver nitrate or sodium iodide. Due to its ... such as isophthalic acid) and aromatic diamines (such as 1,3-diaminobenzene(m-phenylenediamine)) to aramids such as poly (m- ... A modification of the Koenigs-Knorr reaction for building glycosides from 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide ( ...
*  Niphates digitalis
5-di-nitro-benzoic acid and 3,5-di-nitro-salicylic acid". Acta Crystallogr E. 72 (3): 382-386. doi:10.1107/S205698901600267X. ... with the ring-substituted benzoic acid analogues 4-amino-benzoic acid, 3, ...
*  Non-proteinogenic amino acids
... ic acid.) Most natural amino acids are α-amino acids in the L conformation, but some exceptions exist. Some non-α amino acids ... There are various groups of amino acids: 20 standard amino acids 22 proteinogenic amino acids over 80 amino acids created ... Whereas glutamic acid possess one γ-carboxyl group, Carboxyglutamic acid possess two. Hydroxyproline. This imino acid differs ... and a carboxylic acid (-COOH) functional group is an amino acid. The proteinogenic amino acids are small subset of this group ...
*  Balsalazide
... obtained by coupling para-aminobenzoic acid and glycine. That product is then treated with nitrous acid to give the diazonium ... Reaction of this species with salicylic acid proceeds at the position para to the phenol to give balsalazide. Kruis, W.; ... Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that ...
*  Chorismic acid
Chorismate is transformed into para-aminobenzoic acid by the enzymes 4-amino-4-deoxychorismate synthase and 4-amino-4- ... 3-Dihydroxybenzoic acid (DHB) used for enterobactin biosynthesis The plant hormone salicylic acid Many alkaloids and other ... The name chorismic acid derives from a classical Greek word, χωρίζω meaning "to separate", because the compound plays a role as ... Chorismic acid, more commonly known as its anionic form chorismate, is an important biochemical intermediate in plants and ...
*  Competitive inhibition
... active site by mimicking the substrate para-aminobenzoic acid (PABA). This prevents the substrate itself from binding which ... Bacteria must synthesize folic acid because they do not have a transporter for it. Without folic acid, bacteria cannot grow and ... These fatty acids inhibitors have been used as drugs to relieve pain because they can act as the substrate, and bind to the ... Essential fatty acids form the prostaglandins and when this was discovered, it turned out that these were actually very good ...
2016 InformEx  2016 InformEx
3-Aminobenzoic acid, 4,4'-Diaminobenzanilide, 4-Acetamidobenzoic acid, 4-(Acetylamino)benzoic acid-1-(dimethylamino)propan-2-ol ... 4-Aminobenzoic acid (PABA), Ethyl P-Aminobenzoate(Benzocaine), Butyl 4-Aminobenzoate(Butamben), ... 1:1), 3-(Trifluoromethyl)phenol, 4-Hydroxyindole (4-Indolol), 4-Phenoxybenzoic acid, N-BOC-3-hydroxypiperidine, UV-1 ...
more infohttp://fp37.a2zinc.net/clients/fpUBM/Informex2016/Public/eBooth.aspx?IndexInList=46&FromPage=Exhibitors.aspx&ParentBoothID=&ListByBooth=true&BoothID=108582
Global P-Aminobenzoic Acid Market Research Report 2016 : ReportsnReports  Global P-Aminobenzoic Acid Market Research Report 2016 : ReportsnReports
Notes: Production, means the output of P-Aminobenzoic Acid Revenue,... ... Check for Discount on Global P-Aminobenzoic Acid Market Research Report 2016 report by QYResearch Group. ... 1 P-Aminobenzoic Acid Market Overview 1.1 Product Overview and Scope of P-Aminobenzoic Acid 1.2 P-Aminobenzoic Acid Segment by ... of P-Aminobenzoic Acid (2011-2021) 2 Global P-Aminobenzoic Acid Market Competition by Manufacturers 2.1 Global P-Aminobenzoic ...
more infohttp://www.reportsnreports.com/reports/708353-global-p-aminobenzoic-acid-market-research-report-2016.html
p-N,N-Bis(2-chloroethyl)aminobenzoic acid  p-N,N-Bis(2-chloroethyl)aminobenzoic acid
Other names: Benzoic acid nitrogen mustard; Benzoic acid, p-(bis(2-chloroethyl)amino)-; Benzoic acid, 4-(bis(2-chloroethyl) ... p-N,N-Bis(2-chloroethyl)aminobenzoic acid. *Formula: C11H13Cl2NO2 ... amino)benzoic acid * Permanent link for this species. Use this ... InChI=1S/C11H13Cl2NO2/c12-5-7-14(8-6-13)10-3-1-9(2-4-10)11(15)16/h1-4H,5-8H2,(H,15,16) ...
more infohttp://webbook.nist.gov/cgi/inchi?ID=C1141373&Units=CAL
Para-aminobenzoic acid (PABA) - The Source Natural Foods  Para-aminobenzoic acid (PABA) - The Source Natural Foods
... para aminobenzoic acid, paraaminobenzoic acid, para-aminobenzoic acid, para-aminomethylbenzoic acid, PEG-25 PABAs, Peptide-PABA ... p-acetamidobenzoic acid, p-acetamidohippuric acid, p-aminobenzoic acid, p-aminohippuric acid, para-aminobenzoate, para- ... Para-aminobenzoic acid (PABA) is a naturally occurring, non-protein amino acid. It was once thought to be a B vitamin, but is ... ursodeoxycholic acid-p-aminobenzoic acid, vitamin Bx, vitamin H.. *. Combination product examples: Cetacaine , PrimorineTM, ...
more infohttp://www.thesourcenatural.com/ns/DisplayMonograph.asp?storeID=DHAP6V4FB7SR2NM700AKHLBD3CMFBXMD&DocID=bottomline-paraaminobenzoicacid
Plus it  Plus it
... aminobenzoic acid in 10 ml of THF and 10 ml of tert-butyl alcohol was added 10 ml of 5% aqueous sodium bicarbonate. A solution ... aminobenzoic acid. A solution of 2.5 g (0.0123 mol) of 1,5-difluoro-2,4-dinitrobenzene in 25 ml of tetrahydrofuran (THF) was ... The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139. ... The aqueous portion was washed with dichloromethane, acidified with 10% aqueous hydrochloric acid, and extracted with ...
more infohttp://molpharm.aspetjournals.org/content/65/5/1070
Para-aminobenzoic acid (PABA) - B-Healthy  Para-aminobenzoic acid (PABA) - B-Healthy
... para aminobenzoic acid, paraaminobenzoic acid, para-aminobenzoic acid, para-aminomethylbenzoic acid, PEG-25 PABAs, Peptide-PABA ... p-acetamidobenzoic acid, p-acetamidohippuric acid, p-aminobenzoic acid, p-aminohippuric acid, para-aminobenzoate, para- ... Para-aminobenzoic acid (PABA) is a naturally occurring, non-protein amino acid. It was once thought to be a B vitamin, but is ... ursodeoxycholic acid-p-aminobenzoic acid, vitamin Bx, vitamin H.. *. Combination product examples: Cetacaine , PrimorineTM, ...
more infohttp://www.bhealthyonline.com/ns/DisplayMonograph.asp?storeID=XPJ5GAQTH9S92JS100AKHMCCQAUX6Q83&DocID=bottomline-paraaminobenzoicacid
Graduate Thesis Or Dissertation | The quantification of malonaldehyde in marine lipids with para-aminobenzoic acid | ID:...  Graduate Thesis Or Dissertation | The quantification of malonaldehyde in marine lipids with para-aminobenzoic acid | ID:...
The reaction of malonaldehyde with p-aminobenzoic acid involves the condensation of two molecules of p-aminobenzoic acid with ... The p-aminobenzoic acid reaction is highly specific for malonaldehyde and proceeds smoothly and rapidly at room temperature in ... The quantification of malonaldehyde in lipid systems by the use of p-aminobenzoic acid involves the use of a mild reducing ... In this investigation, a method for detecting malonaldehyde through the use of its reaction with p-aminobenzoic acid was ...
more infohttps://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/mc87pt491
Marine Drugs  | Free Full-Text | Cytotoxic Anthranilic Acid Derivatives from Deep Sea  Sediment-Derived Fungus Penicillium...  Marine Drugs | Free Full-Text | Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium...
Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously ... Besides the 2-aminobenzoic acid moiety, the remaining part (C5H4NO) of the structure was established by 2D NMR spectra. The ... to the aromatic carbons C-2 and C-6 implied the presence of the 2-aminobenzoic acid moiety. Meanwhile, the HMBC correlations ( ... Five new anthranilic acid derivatives, penipacids A-E (1-5), along with one known analogue (6), were identified from P. paneum ...
more infohttp://mdpi.com/1660-3397/11/8/3068/htm
Aminobenzoic Acid Derivatives - AMINO ACIDS - Products  Aminobenzoic Acid Derivatives - AMINO ACIDS - Products
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser. ...
more infohttps://www.iris-biotech.de/de/products/amino-acids/aminobenzoic-acid-derivatives.html
Aminobenzoic acids synonyms, Aminobenzoic acids antonyms - FreeThesaurus.com  Aminobenzoic acids synonyms, Aminobenzoic acids antonyms - FreeThesaurus.com
Antonyms for Aminobenzoic acids. 1 word related to aminobenzoic acid: acid. What are synonyms for Aminobenzoic acids? ... aminobenzoic acid. (redirected from Aminobenzoic acids). Also found in: Dictionary, Medical.. Related to Aminobenzoic acids: ... Aminobenzoic acids synonyms, Aminobenzoic acids antonyms - FreeThesaurus.com https://www.freethesaurus.com/Aminobenzoic+acids ... Words related to aminobenzoic acid. a derivative of benzoic acid. Related Words. *acid ...
more infohttp://www.freethesaurus.com/Aminobenzoic+acids
Pure Para-AminoBenzoic Acid (PABA) Powder | BulkSupplements.com  Pure Para-AminoBenzoic Acid (PABA) Powder | BulkSupplements.com
Read Para-AminoBenzoic Acid (PABA) Nutritional Information and Reviews. ... Pure Para-AminoBenzoic Acid (PABA) Powder at BulkSupplements.com - FREE Shipping. ... Para-Aminobenzoic Acid (PABA) is an amino acid that protects skin from harmful UV rays, making it a popular ingredient in ... PABA, Para Aminobenzoic Acid Vitamin B10. 0.25 gram. 19. N-N-Dimethylglycine HCL (DMG), Vitamin B15, 0.5 gram. 20. Methyl- ...
more infohttps://www.bulksupplements.com/para-aminobenzoic-acid-paba.html
Anaesthesia UK : Oral case 65  Anaesthesia UK : Oral case 65
... or a reaction to a derivative of para-aminobenzoic acid, from Novacaine's ester local anesthetic. ... 4. What determines onset of action of local anesthetics?. pKa determines onset of action. The closer the pKa is to the tissue ... 4. How do beta-blockers help a heart in congestive failure? They reduce myocardial oxygen demand by decreasing heart rate and ... 4. Which pulmonary function tests would you use? A standardized measurement of the patient's airflow and lung volumes is ...
more infohttp://www.anaesthesiauk.com/article.aspx?articleid=100257
PABA (Para-Aminobenzoic Acid) | LewisGale Regional Health System  PABA (Para-Aminobenzoic Acid) | LewisGale Regional Health System
Para-Aminobenzoic Acid) at LewisGale Regional Health System Uses Principal Proposed Uses Peyronie's Disease ... ... Para-aminobenzoic acid (PABA) is best known as the active ingredient in sunblock. This use of PABA is not really medicinal: ... The clinical effects of a new B complex factor, para-aminobenzoic acid, on pigmentation and fertility. South Med Surg . 1942; ... 1,2 A 4-month double-blind, placebo-controlled study of 146 people with long-standing, stable scleroderma did not support this ...
more infohttps://lewisgale.com/hl/?/21831/PABA&com.dotmarketing.htmlpage.language=1
Random Ramblings: Essential for life - 90 plus nutrients our bodies require to remain healthy  Random Ramblings: Essential for life - 90 plus nutrients our bodies require to remain healthy
Vitamin B10 (PABA or Para-AminoBenzoic Acid). Vitamin B11 (PHGA or Pteryl-Hepta-Glutamic Acid) ... Vitamin M (Also known as Vitamin B9 or Folic Acid) Vitamin P (Bioflavonoids and Flavonoids - usually occur in the same foods as ... Vitamin F (Essential Fatty Acids Omega 3 and Omega 6 - Omega 9, is usually listed separately) ...
more infohttp://kloggers-randomramblings.blogspot.com/2013/01/essential-for-life-90-plus-nutrients.html
Puritans Pride PABA 500 mg 100 Tablets 2920  Puritan's Pride PABA 500 mg 100 Tablets 2920
Para-Aminobenzoic Acid) is a compound that is an intrinsic component of Folic Acid, an essential nutrient.** PABA ... Intrinsic Component of Folic Acid** PABA (Para-Aminobenzoic Acid) is a compound that is an intrinsic component of Folic Acid, ... Intrinsic Component of Folic Acid** PABA (Para-Aminobenzoic Acid) is a compound that is an intrinsic component of Folic Acid, ... PABA 500 mg * (Para-Aminobenzoic Acid) *Daily Value not established.. *Directions: For adults, take one (1) tablet daily, ...
more infohttp://site365.eu/puritans-pride-paba-500-mg-100-tablets-2920/
Health & Beauty: September 2012  Health & Beauty: September 2012
... and pantothenic acid, Para-Aminobenzoic Acid, vitamin B6 and vitamin B12 that prevent graying and hair loss. Of these, vitamin ... Other nutrients required by the body are proteins and minerals like iron, calcium, zinc, magnesium and essential fatty acids. ... Tanning products contain a chemical called dihydroxyacetone (DHA). This chemical acts an agent that triggers the amino acids in ... Other drugs (Capro amino acid, D-penicillamine, colchicine) have not proven effective. Immunosuppressive drugs (cyclosporine, ...
more infohttp://health-andb.blogspot.com/2012/09/
Gerovital GH3 - Wondrous Roots  Gerovital GH3 - Wondrous Roots
1) PABA (Para-aminobenzoic acid) - stimulates "good" intestinal flora to produce vitamins B and K and Folic Acid. ... BENZOIC ACID/POTASSIUM METABISULPHITE: stabilise the pH value of GH3 at between 3.3 and 3.5 (acidulous). Outside this ...
more infohttp://shopwondrousroots.com/gerovital-gh3/
4-Aminobenzoic acid, TBDMS derivative  4-Aminobenzoic acid, TBDMS derivative
Other names: Benzoic acid, 4-amino-, tert-butyldimethylsilyl ester; tert-Butyl(dimethyl)silyl 4-aminobenzoate; p-Aminobenzoic ... 4-Aminobenzoic acid, TBDMS derivative. *Formula: C13H21NO2Si ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C13H21NO2Si/c1-13
4-Aminobenzoic acid, TMS derivative  4-Aminobenzoic acid, TMS derivative
... *Formula: C10H15NO2Si ... Other names: Benzoic acid, 4-amino-, trimethylsilyl ester * ... InChI=1S/C10H15NO2Si/c1-14(2,3)13-10(12)8-4-6-9(11)7-5-8/h4-7H,11H2,1-3H3 ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C10H15NO2Si/c1-14
4-aminobenzoic acid - Registered substances - ECHA  4-aminobenzoic acid - Registered substances - ECHA
The data comes from registration dossiers submitted to ECHA by the date indicated as last update. The Total Tonnage Band is compiled from all the dossiers with two exceptions; any tonnages claimed confidential and any quantity used as an intermediate to produce a different chemical. The Total Tonnage band published does not necessarily reflect the registered tonnage band(s).. Please note that some of the information on registered substances may belong to third parties. The use of such information may therefore require the prior permission of the third party owners. Please consult the Legal Notice for further information.. ...
more infohttps://echa.europa.eu/information-on-chemicals/registered-substances/-/disreg/substance/100.005.231
  • Xu X-L, Huang F, Zhou G-L, Zhang S, Kong J-L. A Novel Electrochemical Sensor for Probing Doxepin Created on a Glassy Carbon Electrode Modified with Poly(4-Amino- benzoic Acid)/Multi-Walled Carbon Nanotubes Composite Film. (mdpi.com)
  • Four growth phases were clearly identified during the batch cultivation of O. oeni PSU-1 strain, according to the temporal consumption of malic and citric acids, sugar and amino acids uptake, and biosynthesis rates of metabolic products - biomass, erythritol, mannitol and acetic acid, among others. (frontiersin.org)
  • Finally, cysteine shows the fastest specific consumption rate among the amino acids, confirming its key role for bacterial survival under ethanol stress. (frontiersin.org)
  • Calculated speciation curves for ( a ) 3,5-dnba and ( b ) 4-aba in methanol. (iucr.org)
  • MLF and citric acid consumption are vital at high ethanol concentrations, as they are the main source for proton extrusion, allowing higher ATP production by F 0 F 1 -ATPase, the main route of ATP synthesis under these conditions. (frontiersin.org)
  • Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. (rcsb.org)
  • Pretreatment of MPO-high leukemia cells with a MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, or a MPO-specific small interfering RNA (siRNA) abrogated the PTL-induced ROS generation and apoptosis, indicating that MPO plays a crucial role in PTL-induced apoptosis in leukemia cells. (aspetjournals.org)
  • The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. (rcsb.org)