4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.meta-Aminobenzoates: Aminobenzoate derivatives that contain an amino group attached to carbon number 3 or 5 of the benzene ring structure.ortho-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.Aminobenzoates: Derivatives of BENZOIC ACID that contain one or more amino groups attached to the benzene ring structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobenzoate structure.Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.Aniline CompoundsMetabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Alberta: A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)British Columbia: A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Health Records, Personal: Longitudinal patient-maintained records of individual health history and tools that allow individual control of access.Crown Ethers: Macrocyclic polyethers with the repeating unit of (-CH2-CH2-O)n where n is greater than 2 and some oxygens may be replaced by nitrogen, sulfur or phosphorus. These compounds are useful for coordinating CATIONS. The nomenclature uses a prefix to indicate the size of the ring and a suffix for the number of heteroatoms.Rotaxanes: Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.Crowns: A prosthetic restoration that reproduces the entire surface anatomy of the visible natural crown of a tooth. It may be partial (covering three or more surfaces of a tooth) or complete (covering all surfaces). It is made of gold or other metal, porcelain, or resin.Antimutagenic Agents: Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.Ethers, Cyclic: Compounds of the general formula R-O-R arranged in a ring or crown formation.Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Fluorenes: A family of diphenylenemethane derivatives.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Benzoates: Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.Phthalic Acids: A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)Nitrosamines: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.Static Electricity: The accumulation of an electric charge on a objectNitrobenzoates: Benzoic acid or benzoic acid esters substituted with one or more nitro groups.United States Government Agencies: Agencies of the FEDERAL GOVERNMENT of the United States.Nisin: A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.Nimustine: Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.Nitrosourea CompoundsSparsomycin: An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.EstersMeconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.Stearates: Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.Myristates: Salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid.Benzodioxoles: Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.Piperidines: A family of hexahydropyridines.Bentonite: A colloidal, hydrated aluminum silicate that swells 12 times its dry size when added to water.Benzene: Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.Aluminum Silicates: Any of the numerous types of clay which contain varying proportions of Al2O3 and SiO2. They are made synthetically by heating aluminum fluoride at 1000-2000 degrees C with silica and water vapor. (From Hawley's Condensed Chemical Dictionary, 11th ed)Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed)Nitro Compounds: Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.Iraq War, 2003-2011: An armed intervention involving multi-national forces in the country of IRAQ.Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.Nanotubes, Carbon: Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Electrochemical Techniques: The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.Electrochemistry: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.Fluorocarbon PolymersBiosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.

N-acetylation of the heterocyclic amine batracylin by human liver. (1/255)

Batracylin (8-aminoisoindolo[1,2-b]quinazolin-12(10 H)-one; BAT) is a heterocyclic amine that exhibits antitumor activity in a number of in vivo and in vitro models. The acetyl product has been implicated in BAT toxicity in animals, cells, and bacteria. The ability of human N-acetyltransferase (NAT) to form this product was investigated. Nine human liver samples were analyzed for NAT1 and NAT2 genotypes. Seven of the samples possessed at least one NAT1*4 allele. Three samples contained one or more NAT2*4 allele and were classified as rapid acetylators. The remaining six had two alleles associated with the slow phenotype. NAT activities were evaluated with BAT, sulfamethazine (SMZ), a preferential substrate for human NAT2, and p-aminobenzoic acid, a substrate for NAT1. BAT activities in the nine donor samples ranged from 14.9 to 0.56 nmol/min/mg. The mean apparent K(m) values in rapid acetylators for BAT, SMZ, and p-aminobenzoic acid were 6.59 +/- 3.21, 278 +/- 69.4, and 31.2 +/- 12.5 microM, respectively. The apparent K(m) values for slow acetylators did not differ from the rapid acetylator phenotype. However, a significant difference in the apparent V(max) for BAT and SMZ was observed between rapid and slow acetylators. Comparing the apparent intrinsic clearance (V(max)/K(m)) for BAT and SMZ, a significant correlation (r(2) = 0.97, p <.001) was observed. These data demonstrate that BAT N-acetylation is similar to SMZ, and suggests that BAT is a preferential substrate for human NAT2. Thus, rapid acetylators would be more likely to develop toxicity when exposed to this drug.  (+info)

Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. (2/255)

The localization of 5-hydroxytryptamine(4) (5-HT(4)) receptors suggests their role in the regulation of dopamine (DA) neurotransmission, a speculation that has been supported by neurochemical studies. Mesolimbic DA systems play a prominent role in mediating the behavioral effects of the abused psychostimulant cocaine, and the intent of the present study was to assess the role of 5-HT(4) receptors in the control of spontaneous and cocaine-induced activity. Systemic administration of the 5-HT(4) receptor partial agonist 1-(4-amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]1-propa none hydrochloride (RS 67333; 0.0001-1 mg/kg) or the 5-HT(4) receptor antagonist 4-amino-5-chloro-2-methoxy-benzoic acid-(diethylamino)ethyl ester hydrochloride (SDZ 205,557; 0.0001-1 mg/kg) did not significantly alter spontaneous activity, whereas SDZ 205,557 significantly attenuated cocaine-induced horizontal activity and rearing. To test the hypothesis that cocaine-elicited behaviors were modulated by 5-HT(4) receptors in the nucleus accumbens (NAc) shell, two separate groups of male rats were implanted with bilateral cannulas aimed at the NAc shell. Intra-NAc shell microinjections of either RS 67333 (1 or 3 microgram/0.2 microliter/side) or SDZ 205,557 (1-5 microgram/0.2 microliter/side) did not alter spontaneous activity observed after a systemic saline injection but did significantly attenuate the hyperactivity induced by systemic cocaine injection (10 mg/kg). These results support an involvement of 5-HT(4) receptors, particularly those in the NAc shell, in the locomotor stimulatory effects of cocaine. Furthermore, these data suggest that 5-HT(4) receptors may regulate behavioral processes dependent on mesolimbic DA pathways and may provide a novel target for the development of medications useful in the treatment of both drug dependence and psychiatric disorders.  (+info)

Increased levels of dihydrofolate reductase in rifampin-resistant mutants of Bacillus subtilis. (3/255)

Several independent, spontaneous rifampin-resistant mutants of Bacillus subtilis were isolated and found to have an increased resistance to trimethoprim, an inhibitor of dihydrofolate reductase. This increased resistance in the rif mutants was the result of a specific threefold increase in the activity of dihydrofolate reductase, since six other enzymes examined remained unchanged. This increased level of dihydrofolate reductase and the trimethoprim resistance were cotransformed (100%) with the rif marker. These results suggest that the RNA polymerase is altered in its recognition of the gene that specifies dihydrofolate reductase.  (+info)

N-Acetylation of paraphenylenediamine in human skin and keratinocytes. (4/255)

Skin is the major target of allergic reactions to paraphenylenediamine (PPD). Such small molecules require activation to become immunogenic. The balance between activation and/or detoxification processes is critical for immunogenic potentials of compounds. Therefore, we investigated N-acetylation (NAT) capacities of human skin for PPD to gain a better understanding of its mechanisms of action. PPD is acetylated to monoacetyl-PPD (MAPPD), which in turn is acetylated to N,N'-diacetyl-PPD (DAPPD). This was found using cytosolic fractions from human skin (n = 9) and cultured normal human epidermal keratinocytes (n = 7). The cutaneous activities for MAPPD formation ranged from 0.41 to 3.68 nmol/mg/min (9-fold variation) and DAPPD formation from 0.65 to 3.25 nmol/mg protein/min (5-fold), respectively. Similar results were obtained with keratinocytes. NAT activities toward both substrates, PPD and MAPPD, were correlated in keratinocytes (r = 0.930), suggesting that the reactions were catalyzed by the same enzyme. Formation of MAPPD and DAPPD was competitively inhibited in the presence of p-aminobenzoic acid (300 microM), a typical NAT1 substrate, but not by sulfamethazine. These kinetic characteristics suggest that the acetylation of PPD in human skin and keratinocytes is predominantly attributable to the polymorphic NAT1, although both mRNAs (NAT1 and NAT2) are synthesized in human skin and keratinocytes. The metabolism of PPD by NAT1 in human skin and keratinocytes as well as the virtual absence of NAT2 activity may have important toxicological implications. In the case of PPD, our results emphasize that N-acetylation status may be a susceptibility factor for the development of an allergy to PPD.  (+info)

Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. (5/255)

Arylamine N-acetyltransferase-1 (NAT1) is a polymorphically expressed enzyme that is widely distributed throughout the body. In the present study, we provide evidence for substrate-dependent regulation of this enzyme. Human peripheral blood mononuclear cells cultured in medium supplemented with p-aminobenzoic acid (PABA; 6 microM) for 24 h showed a significant decrease (50-80%) in NAT1 activity. The loss of activity was concentration-dependent (EC(50) approximately 2 microM) and selective because PABA had no effect on the activity of constitutively expressed lactate dehydrogenase or aspartate aminotransferase. PABA also induced down-regulation of NAT1 activity in several human cell lines grown at confluence. Substrate-dependent down-regulation was not restricted to PABA. Addition of other NAT1 substrates, such as p-aminosalicylic acid, ethyl-p-aminobenzoate, or p-aminophenol to peripheral blood mononuclear cells in culture also resulted in significant (P <.05) decreases in NAT1 activity. However, addition of the NAT2-selective substrates sulfamethazine, dapsone, or procainamide did not alter NAT1 activity. Western blot analysis using a NAT1-specific antibody showed that the loss of NAT1 activity was associated with a parallel reduction in the amount of NAT1 protein (r(2) = 0.95). Arylamines that did not decrease NAT1 activity did not alter NAT1 protein levels. Semiquantitative reverse transcriptase polymerase chain reaction of mRNA isolated from treated and untreated cells revealed no effect of PABA on NAT1 mRNA levels. We conclude that NAT1 can be down-regulated by arylamines that are themselves NAT1 substrates. Because NAT1 is involved in the detoxification/activation of various drugs and carcinogens, substrate-dependent regulation may have important consequences with regard to drug toxicity and cancer risk.  (+info)

Sensitive and selective determination of tetracaine and its metabolite in human samples by gas chromatography-mass spectrometry. (6/255)

A sensitive and reliable method was developed for the determination of tetracaine and its metabolite, p-butylaminobenzoic acid, in human samples. Tetracaine and the metabolite, effectively extracted using a liquid-liquid extraction procedure from 0.5 g of sample, were analyzed by gas chromatography-mass spectrometry. Tetracaine was analyzed without derivatization, and the metabolite was analyzed after tert-butylolimethylsilyl derivatization. Dibucaine and p-dimethylaminobenzoic acid were used as internal standards for tetracaine and the metabolite, respectively. The calibration curve for each compound was linear in the concentration range from 10 to 1,000 ng/0.5 g, and the lower limits of detection were 10 ng/g for tetracaine and 0.6 ng/g for the metabolite in whole blood and tissues. The accuracy and precision of the method were evaluated in whole blood and brain at the concentrations of 50 ng/0.5 g and 500 ng/0.5 g for tetracaine and 10 ng/0.5 g and 100 ng/0.5 g for the metabolite. The coefficients of variation ranged from 0.8 to 3.0% for tetracaine and 2.4 to 9.8% for the metabolite. We used this method to determine tetracaine and its metabolite in human whole blood and tissues of an autopsied patient who died during spinal anesthesia induced by tetracaine.  (+info)

Inhibition of the development of the cellular slime mould Dictyostelium discoideum by omega-aminocarboxylic acids. (7/255)

Four omega-aminocarboxylic acids - epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexane-1-carboxylic acid (t-AMCHA), p-aminomethylbenzoic acid (PAMBA) and omega-aminocaprylic acid (OACA) -- prevented fruiting body formation of the cellular slime mould Dictyostelium discoideum. At concentrations of 40 mM, 75 mM, 10 mM and 5 mM, respectively, they allowed aggregation but prevented all further development at 24 degrees C. At lower concentrations, EACA allowed fruiting body formation but with a reduced number of spores per fruiting body. Only t-AMCHA had a significant inhibitory effect on the growth of myxamoebae. EACA affected development only if it was present between 8 and 16 h after the cells were deposited on the filters. Its effect was enhanced by high salt concentrations and by higher temperature, and was also dependent on the manner in which the cells were grown. Only strains capable of axenic growth displayed this sensitivity to EACA, although strains carrying only one of the genetic markers for axenic growth (axe A) were partially sensitive.  (+info)

The effect of epsilon-aminocaproic acid on biochemical changes in the development of the cellular slime mould Dictyostelium discoideum. (8/255)

epsilon-Aminocaproic acid (EACA) inhibited the development of Dictyostelium discoideum strain AX2 after the aggregation stage. Biochemical changes that occurred early in development (loss of cellular protein, RNA and carbohydrate; increase in the specific activity of N-acetylglucosaminidase, alpha-mannosidase, threonine deaminase and leucine aminopeptidase) were not affected by concentrations of EACA which blocked development; but biochemical changes that occurred later (synthesis of carbohydrate, increase in the specific activity of UDP-glucose pyrophosphorylase) were inhibited. Spores from fruiting bodies formed in the presence of low concentrations of EACA were larger, more spherical and less able to survive heat treatment than spores from fruiting bodies of control (no EACA) cells.  (+info)

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4-aminobenzoic acid, 4-aminobenzoic acid hydrazide, ABAH, Aktipol , aminobenzoate potassium, BAB, BT-PABA, butyl aminobenzoate, cyclic amino acid, disulphate ester of ursodeoxycholyl-p-aminobenzoic acid, ester oxybenzone, ethyl p-aminobenzoate, ethyl-4-N,N-dimethylaminobenzoate, ethyl dihydroxypropylaminobenzoate, glyceryl paraaminobenzoate, isobutyl p-aminobenzoate, KPAB, K-para-aminobenzoate, monoglyceryl para-aminobenzoate, n-benzyol-l-tyrosyl-p-aminobenzoic acid, NBT-PABA, n-butyl-p-aminobenzoate, n-diethyl-methyl-ammonium ethyl bromide-p-[2(n-octyloxy)-benzoyl-]aminobenzoate, N,N-dimethyl-2-ethylhexyl para-aminobenzoate, octyl dimethyl PABA, Pabafil , PABA-UDCA, padimate O, PAMBA, p-acetamidobenzoic acid, p-acetamidohippuric acid, p-aminobenzoic acid, p-aminohippuric acid, para-aminobenzoate, para-aminobenzoate potassium, para aminobenzoic acid, paraaminobenzoic acid, para-aminobenzoic acid, para-aminomethylbenzoic acid, PEG-25 PABAs, Peptide-PABA, Photoplex, POTABA , potassium ...
4-aminobenzoic acid, 4-aminobenzoic acid hydrazide, ABAH, Aktipol , aminobenzoate potassium, BAB, BT-PABA, butyl aminobenzoate, cyclic amino acid, disulphate ester of ursodeoxycholyl-p-aminobenzoic acid, ester oxybenzone, ethyl p-aminobenzoate, ethyl-4-N,N-dimethylaminobenzoate, ethyl dihydroxypropylaminobenzoate, glyceryl paraaminobenzoate, isobutyl p-aminobenzoate, KPAB, K-para-aminobenzoate, monoglyceryl para-aminobenzoate, n-benzyol-l-tyrosyl-p-aminobenzoic acid, NBT-PABA, n-butyl-p-aminobenzoate, n-diethyl-methyl-ammonium ethyl bromide-p-[2(n-octyloxy)-benzoyl-]aminobenzoate, N,N-dimethyl-2-ethylhexyl para-aminobenzoate, octyl dimethyl PABA, Pabafil , PABA-UDCA, padimate O, PAMBA, p-acetamidobenzoic acid, p-acetamidohippuric acid, p-aminobenzoic acid, p-aminohippuric acid, para-aminobenzoate, para-aminobenzoate potassium, para aminobenzoic acid, paraaminobenzoic acid, para-aminobenzoic acid, para-aminomethylbenzoic acid, PEG-25 PABAs, Peptide-PABA, Photoplex, POTABA , potassium ...
Synonyms for Aminobenzoic acids in Free Thesaurus. Antonyms for Aminobenzoic acids. 1 word related to aminobenzoic acid: acid. What are synonyms for Aminobenzoic acids?
Learn more about PABA (Para-Aminobenzoic Acid) at LewisGale Regional Health System Uses Principal Proposed Uses Peyronies Disease ...
Malonaldehyde, a very reactive member of the homologous series of dialdehydes, is associated with the autoxidative deterioration of lipids. Its measurement, in autoxidized lipid systems is an expression of the extent of oxidation, in lipids. Malonaldehyde lends itself well to such determinations because of the sensitivity and specificity of its quantification in complex lipid systems. Complete knowledge of the formation of malonaldehyde in autoxidized lipids. is lacking. Such knowledge would undoubtedly promote a better understanding of lipid autoxidation mechanisms. In this investigation, a method for detecting malonaldehyde through the use of its reaction with p-aminobenzoic acid was developed. This was adapted for use in measuring malonaldehyde in lipids and in tissue samples. The reaction between p-aminobenzoic acid and malonaldehyde was partially characterized, and a mechanism for the formation of the reaction product was postulated. The quantification of malonaldehyde in lipid systems by ...
[118 Pages Report] Check for Discount on Global P-Aminobenzoic Acid Market Research Report 2016 report by QYResearch Group. Notes: Production, means the output of P-Aminobenzoic Acid Revenue,...
PABA 100 mg - 100 tabletsRecommended Use:One tablet daily, or as recommended by your health care professional.Paba, or para-aminobenzoic acid, is generally classified with the B-vitamin family, although it is not itself a vitamin. Its best known role is as a precursor for folic acid production.Ingredients:Para-Aminobenzoic Acid 100mg.WARNING: Keep out of the reach of children. Do not use if either tamper-evident seal is broken or missing. If you are pregnant or nursing, consult your health care professional before using this product. Suitable for vegetarians and hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
The present disclosure provides compositions and methods for the biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid and the purification of biologically derived acetaminophen.
Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits. Folates are required for DNA synthesis and epigenetic regulation. In addition to dietary nutrients, the gut microbiota has been recognized as a source of B complex vitamins, including folate. This study evaluated the predicted folate synthesis capabilities in the genomes of human commensal microbes identified in the Human Microbiome Project and folate production by representative strains of six human intestinal bacterial phyla. Bacterial folate synthesis genes were ubiquitous across 512 gastrointestinal reference genomes with 13% of the genomes containing all genes required for complete de novo folate synthesis. An additional 39% of the genomes had the genetic capacity to synthesize folates in the presence of pABA, an upstream intermediate that can be obtained
In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your medical doctor, dentist, or nurse will make. For local anesthetics, the following should be considered:. Allergies - Tell your medical doctor, dentist, or nurse if you have ever had any unusual or allergic reaction to a local anesthetic or to epinephrine (e.g., Adrenalin). Also tell your medical doctor, dentist, nurse, or pharmacist if you are allergic to any other substances, such as sulfites or other preservatives, especially aminobenzoic acid (also called para-aminobenzoic acid [PABA]). Pregnancy - Local anesthetics have not been reported to cause birth defects in humans.. Use of a local anesthetic during labor and delivery may rarely cause unwanted effects. These medicines may increase the length of labor by making it more difficult for the mother to bear down (push). They may also cause unwanted effects in the fetus or newborn baby, especially if ...
Health Site365. Puritans Pride PABA 500 mg 100 Tablets 2920. Intrinsic Component of Folic Acid** PABA (Para-Aminobenzoic Acid) is a compound that is an intrinsic component of Folic Acid, an essential nutrient.** PABA
Description: This product is designed using a patent-pending, two-stage, timed-release technology. The PABA is formulated so that half of it is rapidly released and the other half is gradually released over a period of 12 hours. The two-stage, timed-release technology helps to extend the availability of PABA to the body over a longer period of time. Size: 100ct 700mg Directions: As a dietary supplement, take one capsule daily or as needed. Serving Size: 1 Capsule 100 Servings per container Ingredients: Amount Per Serving - % Daily Value PABA (Para-Aminobenzoic Acid) 700 mg Other Ingredients: Vegetarian Cellulose Capsule, Stearic Acid, Silica and Magnesium Stearate
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of p-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada ...
Probiotic bacteria, mostly belonging to the genera Lactobacillus and Bifidobacterium, confer a number of health benefits to the host, including vitamin production. With the aim to produce folate-enriched fermented products and/or develop probiotic supplements that accomplish folate biosynthesis in vivo within the colon, bifidobacteria and lactobacilli have been extensively studied for their capability to produce this vitamin. On the basis of physiological studies and genome analysis, wild-type lactobacilli cannot synthesize folate, generally require it for growth, and provide a negative contribution to folate levels in fermented dairy products. Lactobacillus plantarum constitutes an exception among lactobacilli, since it is capable of folate production in presence of para-aminobenzoic acid (pABA) and deserves to be used in animal trials to validate its ability to produce the vitamin in vivo. On the other hand, several folate-producing strains have been selected within the genus Bifidobacterium, with a
Aminodeoxychorismate synthase/glutamine amidotransferase ; Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity (902 aa ...
Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine ...
GH3 Formula - functions and constituents formulated by Dr. Prof Ana Aslan of Romania. PROCAINE HCl : Hydrolyses in the body into its two elements:. (1) PABA (Para-aminobenzoic acid) - stimulates "good" intestinal flora to produce vitamins B and K and Folic Acid.. (2) DEAE (Diethylaminoethanol) - generates choline and acetylcholine, both of which are essential to the effective functioning of the spleen, liver, brain and nerve impulse relays. It also normalises the level of mono-amine oxidase (MAO) in the brain, thereby functioning as an antidepressant.. METABISULPHITE: has blood cleaning and arterial cleaning effect, and works towards reducing hypertension.. POTASSIUM: stabilises the Procaine molecule to extend and reinforce its actions on the nervous system.. SODIUM: works primarily as a buffering agent to protect the Procaine whilst it works within the body.. ...
Since the early stuttering of mans realisation that nutrition and the quality of food is the main ingredient to good health we are slowly beginning to learn the vital importance of everything that we put into our bodies. This is a slow and often painful path to gain true knowledge. Indeed there are many who have laid down the gauntlet many years ago without effort, care, knowledge, tests or experiments and sadly even in our wisdom we are still following their dictations.. Mans beliefs regarding essential nutrients at the moment:. Essential Vitamin List. Vitamin A (Retinol) Vitamin B1(Thiamine). Vitamin B2 (Riboflavin). Vitamin B3 (Niacin). Vitamin B4 (Choline). Vitamin B5(Pantothenic Acid). Vitamin B6 (Pyridoxine). Vitamin B7 (Biotin). Vitamin B8 (Inositol). Vitamin B9 (Folic Acid). Vitamin B10 (PABA or Para-AminoBenzoic Acid). Vitamin B11 (PHGA or Pteryl-Hepta-Glutamic Acid). Vitamin B12 (Cobalamin). Vitamin C (Ascorbic Acid). Vitamin C (Ascorbinogen). Vitamin C (Rutin used by blood ...
COMPLEX BLEND OF QUALITY INGREDIENTS - Vitamin C, Vitamin B-1, Vitamin B-2, Vitamin B-3, Vitamin B-5, Vitamin B-6 , Vitamin B-7 (Biotin), Vitamin B-12, Folic Acid, pantothenic acid, calcium, magnesium, choline bitartrate, inositol, PABA (para-aminobenzoic acid), hops flower powder, chamomile flower powder, valerian root powder, passion flower (herb & flower). ARE YOU FEELING OVERWHELMED?… Read More » ...
COMPLEX BLEND OF QUALITY INGREDIENTS - Vitamin C, Vitamin B-1, Vitamin B-2, Vitamin B-3, Vitamin B-5, Vitamin B-6 , Vitamin B-7 (Biotin), Vitamin B-12, Folic Acid, pantothenic acid, calcium, magnesium, choline bitartrate, inositol, PABA (para-aminobenzoic acid), hops flower powder, chamomile flower powder, valerian root powder, passion flower (herb & flower). ARE YOU FEELING OVERWHELMED?… Read More » ...
Maltodextrin, Protein Blend (Whey Protein Concentrate, Calcium Caseinate, Egg Albumen, Sweet Dairy Way), Creatine Monohydrate, L-Glutamine, Glutamine Peptides, Choline (as Choline Bitartrate), Inositol, Paba (Para-Aminobenzoic Acid), Artificial Flavor, Vitamin & Mineral Blend (Di-Potassium Phosphate, Magnesium Aspartate, Di-Calcium Phosphate, Calcium Citrate, Ascorbic Acid, Niacinamide, Zinc Citrate, Beta Carotene, d-Calcium Pantothenate, d-alpha Tocopherol Succinate, Selenomethionine, Copper Gluconate, Ferrous Fumarate, Manganese Amino Acid Chelate, Thiamin Mononitrate, Pyridoxine Hydrochloride, Riboflavin, Chromium Picolinate, Folic Acid, Biotin, Molybdenum Amino Acid Chelate, Cholecalciferol, Potassium Iodide, Cyanocobalamin), Medium Chain Tri-glycerides, Acesulfame ...
Green Guidance The Truth in Beauty by Mindy Pennybacker, with reporting by Molly Rauch and Claire Gutierrez Not for nothing did our ancestors worship the sun, the source of Earths fertility and associated revels. What the ancients didnt understand, however, was the link between sun exposure and skin cancer. Whether you celebrate the season on a mountaintop or basking by the swimming hole, it pays to protect your skin. The key: read ingredient lists, and dont be caught napping at the expense of your or your childrens health. Sunscreens and Sunblocks. The skin is an absorptive organ, so it makes sense to use the least toxic products on it. Unfortunately, most sunscreens contain at least some iffy chemicals, including benzophenone, homosalate, and octy-methoxycinnamate, shown in animal tests to disrupt hormones and affect development of the brain and reproductive organs. PABA (para-aminobenzoic acid) has caused allergic reactions, and padimate-O and parsol 1789 (avobenzone) have the potential ...
A nutrient-rich diet contributes to a healthy head of hair. Without omega-3 fatty acids, hair is often dry and lifeless. Foods rich in biotin, copper, zinc, selenium, and para-aminobenzoic acid (PABA) may promote hair growth or slow hair loss. Note that foods containing raw egg should be avoided because raw egg binds biotin and prevents it from being absorbed by the body. (In any case, raw eggs should be avoided because of the risk of salmonella.) Please see related links for additional information on psoriasis and eczema, which may cause a flaking and itching scalp that contributes to hair problems. Mega-Recipes ...
People who are allergic to para-aminobenzoic acid (PABA) may also be allergic to Tessalon. This eMedTV discusses this possibility in more detail and describes several other important warnings and precautions to be aware of before taking Tessalon.
Amino esters are a class of local anesthetics. They are named for their ester bond (and are unlike amide local anaesthetics). Structurally, local anesthetics consist of three molecular components: a lipophilic part an intermediate aliphatic chain a hydrophilic (amine) part The chemical linkage between the lipophilic part and the intermediate chain can be of the amide-type or the ester-type, and is the general basis for the current classification of local anesthetics. Amino esters, in reference to anesthetic agents, are rapidly metabolized in the plasma by butyrlcholinesterase to para-aminobenzoic acid derivatives, then excreted in the urine. This suggests their very short half lives. Allergy is more likely to occur with ester-type agents, as opposed to amide-type. Amino ester-type include: Cocaine Procaine (Novocain) Tetracaine (Pontocaine) Benzocaine University of Texas Med School, Pharmacology Syllabus. Katzung. 10th edition. Chapter 26 ...
Is regional anesthesia indicated?. 1. Should you avoid using local anesthetics?. No. His "allergic" reaction could have been an intravascular injection, a reaction to epinephrine added to the solution, or a reaction to a derivative of para-aminobenzoic acid, from Novacaines ester local anesthetic.. 2. What determines potency of local anesthetics?. Lipid solubility determines potency. The higher the solubility, the more potent the agent is.. 3. What determines duration of action of local anesthetics?. Protein binding determines duration of action. The more the protein binding, the longer the duration of action.. 4. What determines onset of action of local anesthetics?. pKa determines onset of action. The closer the pKa is to the tissue pH, the faster the onset. All local anesthetics are weak bases, so those with a pKa near 7.4 have more molecules that are lipid-soluble and unionized.. ...
Sulfonamides, https://clenbuterolpillsforsale.net unhurtfully such as sulfamethoxazole, are similar in structure to para-aminobenzoic acid, a compound critical for synthesis of folic acid! Em pacientes com função renal normal, a meia-vida plasmática de eliminação do aciclovir após dosagens únicas ou múltiplas de valaciclovir é de aproximadamente 3 horas? Genauso brauchen Cialis Soft Tabs auch den sexuellen Reiz, new weight loss drug with topamax and phentermine denn ohne diesen geschieht einfach nichts. Применение при нарушениях функции печениС осторожностью применять при заболеваниях печени, topamax cost особенно в течение длительного времени? The vector may be an autonomously replicating vector, ie, a vector which exists as an extrachromosomal entity, the replication of which is independent of chromosomal replication, eg, a plasmid, an extrachromosomal element, a ...
Buy Letus Online! Letus is a sulfonamide derivative antibiotic that interferes with bacterial folic acid synthesis and growth by blocking dihydrofolic acid formation from para-aminobenzoic acid. Active against a variety of organisms, including Staphylococcus species, E. coli, Stenotrophamonas maltophilia, Nocardia species, Toxoplasma gondii, Pneumocystis (PCP), and Isospora belli.
Buy Bacta Online! Bacta is a sulfonamide derivative antibiotic that interferes with bacterial folic acid synthesis and growth by blocking dihydrofolic acid formation from para-aminobenzoic acid. Bacta is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency.
Product Description:Balanced High Potency Vitamin B-ComplexIngredients:1 Tablet Contains:Daily ValueThiamine (Vitamin B1) 110 mg 7333Riboflavin (Vitamin B2) 55 mg 3235Niacinamide 165 mg 825Vitamin B6 (Pyridoxine) 60 mg 3000Folic Acid 400 mcg 100 Vitamin B12 (Cobalamin) 100 mcg 1667Biotin 300 mcg 100Pantothenic Acid 110 mcg 1100 Choline 80 mg In a base of Inositol 50 mg and Para-Aminobenzoic Acid 30 mg.Daily Value not established Other Ingredients:Dicalcium Phosphate, Terra Alba (Calcium Sulfate), Magnesium Stearate and Stearic Acid.Dosage:One tablet daily following a meal.
para que sirve el medicamento baclofen 10 mg The company said it will perform an additional Phase II study utilizing 100 milligram and higher doses.para que es metoprolol 50 mg The fact that civilian defense workers returned to work one week into the. dosagem ciprofloxacina caes The Alternative for.Home » Bactrim Dla 4 Latka A+ R A-Sabonner à ce flux RSS. Bactrim Dla 4 Latka.Uro are there withdrawal symptoms from clonazepam Bactrim - Bula de Uro Bactrim - bulario.com Bula de Uro Bactrim: para que serve, como tomar, dosagem / posologia e.Generic Biseptol dosage and administration. naproxene and para-aminobenzoic acid derivatives. Is generic Biseptol is the same as brand Biseptol or brand Bactrim?.Bactrim Ds Cost Publix bactrim septra for acne bactrim 480 mg dosage generico do bactrim infantil youre asked to order trimethoprim Norateen alongside protein you.. ...
Nutrition is very important for the body. Even though hair and fingernails are just dead cells, they are an important indicator of the general well being of a person. Nutrition for the body is derived from the food we take. When the body does not receive the essential nutrients, or if it loses the ability to absorb nutrients from the food it receives, it causes the body to use up internal resources. This causes weakness in the body parts and is reflected in the skin, hair and fingernails. In order to have healthy hair and finger nails, it is very important to consume food that contains some major vitamins like vitamin A (produces healthy sebum in the scalp), vitamin C (antioxidant), vitamin E (improves scalp circulation), Biotin (produces Keratin), Inositol (keeps hair follicles healthy), Niacin (promotes scalp circulation) and pantothenic acid, Para-Aminobenzoic Acid, vitamin B6 and vitamin B12 that prevent graying and hair loss. Of these, vitamin E is found to have a significant influence on ...
Biosynthetic Production of 4-Amino 4-Deoxychorismate (Adc) and [3R,4R]-4-Amino-3-Hydroxycyclohexa-1,5-Diene-1-Carboxylic Acid (3,4-Cha) - The invention relates to a process for the biosynthetic production of 4-amino-4-deoxychorismate (ADC) performed fermentatively in vivo with a 4-amino-4-deoxychorismate synthase, preferably a PabAB bipartite protein (which may be a fusion protein), at an increased level of activity, thereby obtaining a broth comprising ADC and 4-amino-4-deoxyprephenate (ADP), that are recovered. The invention also relates to a further process of converting the ADP into p-aminophenylalanine. The invention, moreover relates to biosynthetic production of [3R,4R]-4-amino-3-hydroxycyclohexa-1,5-diene-1-carboxylic acid (3,4-CHA), by concerted action of such 4-amino-4-deoxychorismate synthase and of an enzyme capable of converting isochorismate into [5S,6S]-5,6 dihydroxycyclohexa-1,3-diene-1-carboxylic acid (2,3-CHD), preferably a phenazine biosynthesis protein PhzD, including ...
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
1K0E: Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes.
The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s.[24][25][26] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet formulations so that when they enter the body their concentration in the blood and tissues is roughly one-to-twenty - the exact ratio required for a peak synergistic effect between the two.[12]. Sulfamethoxazole, a sulfonamide, induces its therapeutic effects by interfering with the de novo (that is, from within the cell) synthesis of folate inside microbial organisms such as protozoa, fungi and bacteria. It does this by competing with p-aminobenzoic acid (PABA) in the biosynthesis of dihydrofolate.[12]. Trimethoprim serves as a competitive inhibitor of dihydrofolate reductase (DHFR), hence inhibiting the de novo synthesis of tetrahydrofolate, the biologically active ...
Molecular Modeling for the Design of PABA/NO. The Meisenheimer complexes formed by GSH and PABA/NO for GSTπ and GSTα were built based on those for JS-K (Shami et al., 2003). The models were subject to geometry optimization and docked into the active sites of GSTπ (Prade et al., 1997) and GSTα (Sinning et al., 1993), respectively. Model building was carried out with computer graphics program O (Jones and Kjeldgaard, 1997) and energy minimization with Crystallography & NMR System software (Brünger et al., 1998). Illustrations were generated with software packages Grasp (Nicholls et al., 1991), Molscript (Kraulis, 1991), and Raster3D (Merritt and Bacon, 1997).. Preparation of 4-[N-(2,4-Dinitro-5-fluorophenyl)-N-methyl]-aminobenzoic acid. A solution of 2.5 g (0.0123 mol) of 1,5-difluoro-2,4-dinitrobenzene in 25 ml of tetrahydrofuran (THF) was placed in a 100-ml round-bottomed flask. To this was added 2.6 g (0.025 mol) of anhydrous sodium carbonate. To the stirred mixture was added a solution of ...
3-(2-Aminoethyl)indol-5-ol p-aminobenzoate dihydrochloride | C17H19Cl2N3O2 | CID 29683 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
The sulfonamides are weakly acidic compounds that have a common chemical nucleus resembling p-aminobenzoic acid (PABA). Members of this group differ mainly in their pharmacokinetic properties and clinical uses. Pharmacokinetic features include modest tissue penetration, hepatic metabolism, and excretion of both intact drug and acetylated metabolites in the urine. Solubility may be decreased in acidic urine, resulting in precipitation of the drug or its metabolites. Because of the solubility limitation, a combination of 3 separate sulfonamides ...
This study deals with the hourly determination of metabolic differences during growth with sulphathiazole (ST) between the ST-sensitive and ST-resistant strains of Escherichia coli and Staphylococcus aureus for the timing of the onset of resistance mechanism. The amounts of the extracellularly accumulated p-aminobenzoic acid (PAB), folic acid (FA) and citrovorum factor (CF) in the culture fluids and the growth rates are determined. As described in the preceding paper, the sequence of metabolic events with these strains is of the same pattern. The PAB curve in the resistant cell system with ST rises perpendicularly to a peak and then declines sharply followed by the rise of the growth curve. In contrast, in the sensitive cell system with ST, the PAB curve, after reaching a peak, forms a longlasting plateau or a dome-like plateau. During these plateau periods growth is absent. The decline in the plateau is followed by growth. In both the sensitive and resistant strains (E. coli), the ...
Analogs of 3-Benzylideneanabaseine. Syntheses of DMXBA and two O-demethylated analogs (Fig. 1A) were described by Kem et al. (2004). The dihydrochloride salts were dissolved in the appropriate physiological saline, and stock solutions were aliquoted and frozen. Because DMXBA is light-sensitive, the compounds were not exposed to strong light.. Isolation ofXenopus laevisOocytes.X. laevis frogs were kept in tanks of dechlorinated tap water on a 10-h light/14-h dark cycle at 19°C and fed a diet of AquaMax 500 grower (Purina Mills, St. Louis, MO) three times per week. Frogs were anesthetized by immersion in ice-cold 0.12% 3-aminobenzoic acid ethyl ester for 20 min. After removal through a small incision in the frogs abdomen, ovarian lobes were placed in modified Barths solution (MBS) containing 88 mM NaCl, 1 mM KCl, 2.4 mM NaHCO3, 10 mM HEPES, 0.82 mM MgSO4, 0.33 mM Ca(NO3)2, and 0.91 mM CaCl2, pH 7.5.. Ovarian lobes were manually dissected into clumps of four to ten oocytes and were then ...
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Bacteria PabC protein: closely related to D-alanine aminotransferase; involved in p-aminobenzoate synthesis; amino acid sequence given in first source
aminodeoxychorismate synthase, subunit II (Escherichia coli), Uniprot accession P00903 (peptidase unit: 24-187), MERNUM MER0043394 ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Best price in Australia on Now Foods PABA 500 mg - 100 Caps from eVitamins.com. Find PABA 500 mg reviews, side effects, coupons and more from eVitamins. Fast and reliable shipping to the Australia. PABA 500 mg and other products by Now Foods for all your health needs.
Pharmacology Review Sheets: Antibiotics, p.1Sulfonamides. Common Properties- Structure: Substitutions put ~ ring. ↓. activity- P-aminobenzoic stinging (PABA) analog- Competitively inhibits pteroic sharp synthetase- Absolutely specifically toic- Bacteriostatic- !eeds time to ta"e issue (effects aren#t immediate)- $esistance. •. ↑. PABA reduction by evaporation-. ↓. upta"e of sulfonamides-. ↓. affinity of pteroic acid synthetase for enzyme- Spectrum: %&s nocardiosis chlamydial infections- istribution. •. *ets into C!S (flat +ithout inflammation)- oesn#t pass prostate +ell because it#s acidic- ,etabolism and cretion- Parent or acetylated derivative ecreted in the urine- Adverse movables- rug Allergy: Stevens-.ohnson#s syndrome (necrotizing forfeiture of s"in). •. Crystaluria (esp/ +ith older sulfonamides)- 0ernicterus: yello+ing of fingernails and sclera potential neurological symptoms-. D!"# give to women in $. rd. three months, nursing mothers, ...
|strong||em|Result|/em||/strong|: Energizes & alkalinizes the body, promoting vitality you can feel. |strong||em|Benefit|/em||/strong|: 40 essent ...
Examples in chemistry include Tyrosine and 4-aminobenzoic acid. The former may be deprotonated to form the carboxylate and ...
Hypochlorous acid and tyrosyl radical are cytotoxic, so they are used by the neutrophil to kill bacteria and other pathogens. ... However, this hypochlorous acid may also cause oxidative damage in host tissue. Moreover, MPO oxidation of apoA-I reduces HDL- ... MPO is a member of the XPO subfamily of peroxidases and produces hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and ... MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to ...
that is mildy soluble in water (1 part in 7000) and soluble in alcohol, ether, chloroform, fixed oils, and dilute acids. It ... It is the ester of 4-aminobenzoic acid and butanol. A white, odourless, crystalline powder. ...
... is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging ... It can be reacted with 4-aminobenzoic acid to make procaine. DEAE can be used as a precursor for DEAE-cellulose resin, which is ...
... is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification ... ester of para-aminobenzoic acid as a local anaesthetic), Klinische Wochenschrift, vol. 39, pages 373-375. Guénette, SA; Giroux ... In industrial practice, the reducing agent is usually iron and water in the presence of a little acid. Benzocaine was first ... Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform, and ethyl ...
... obtained by coupling para-aminobenzoic acid and glycine. That product is then treated with nitrous acid to give the diazonium ... Reaction of this species with salicylic acid proceeds at the position para to the phenol to give balsalazide. Kruis, W.; ... Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that ...
U.S. Patent 3,634,583 (1972). Feit, P. W. (1971). "Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamoylbenzoic ... 5-phenoxybenzoic acid. Finally, reacting this with butyl alcohol in the presence of sulfuric acid gives the desired bumetanide ... In the first stage of synthesis, it undergoes sulfonylchlorination by chlorosulfonic acid, forming 4-chloro-3- ... chlorosulfonylbenzoic acid, which is further nitrated with nitric acid to 4-chloro-3-chlorosulfonyl-5-nitrobenzoic acid. ...
... is a precursor in the synthesis of dihydrofolic acid in many microorganisms. The enzyme dihydropteroate synthetase ... converts pteridine and 4-aminobenzoic acid to dihydrofolic acid in the presence of glutamate. The enzyme dihydropteroate ...
... is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which ... the resulting acid chloride is then esterified with 2-diethylaminoethanol to give Nitrocaine. Finally, the nitro group is ... The first consists of the direct reaction of the 4-aminobenzoic acid ethyl ester with 2-diethylaminoethanol in the presence of ... Retrieved 4 September 2015. Einhorn, A.; Fiedler, K.; Ladisch, C.; Uhlfelder, E. (1909). "Ueber p-Aminobenzoësäurealkaminester ...
... yellowish water-insoluble oily liquid is an ester formed by the condensation of 2-ethylhexanol with dimethylaminobenzoic acid. ... 35 (4): 546-9. doi:10.1016/S0190-9622(96)90677-5. PMID 8859281. Kerr, Caroline (1998). "The effects of two UVB radiation- ... 9 (3-4): 323-334. doi:10.1016/1011-1344(91)80169-I. Bissett, Donald L; McBride, James F (1996). "Synergistic topical ... Padimate O is an organic compound related to the water-soluble compound PABA (4-aminobenzoic acid) that is used as an ...
1985 Feb 1;151(3):322-4. Chestnut: Obstetric Anesthesia, 3rd ed, p333. Hughes: Anesthesia for Obstetrics, 4th ed, p75.. ... The hydrochloride salt of 4-amino-2-chlorobenzoyl chloride is made by the reaction of 2-chloro-4-aminobenzoic acid with thionyl ...
The resulting L-amide is selectively hydrolyzed by sequential use of dimsyl sodium (NaDMSO) and dilute acid to give bentiromide ... The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting ... 4 H_bond_acceptor=5 Synthetic chymotrypsin-labile peptide, used in diagnosis of exocrine pancreatic disease. It is synthesized ... 4). Chronic pancreatitis Bentiromide - Compound Summary, PubChem. P. L. De Benneville, N. J. Greenberger, DE 2156835 ; eidem, U ...
pK, ΔHo, and ΔSo values for proton ionization from o-, m-, and p-Aminobenzoic Acids and their methyl esters at 25 oC. J. Phys. ... nucleic acid chemistry, metal cyanide chemistry, chemical separations, amino acid microspecies formation, and high- temperature ... Izatt, R. et al Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, ... deoxyribonucleic acid, and their constituent bases, nucleosides, and nucleotides. Chem. Rev. 1971 vol 71 pp439-481. Oscarson, J ...
Other metabolites of procainamide include desethyl-N-acetylprocainamide, desethylprocainamide, p-aminobenzoic acid, which are ... These are aromatic carboxylic acid derivatives consisting of an amide with a benzamide moiety and a triethylamine attached to ... N-acetyl-4-aminobenzoic acid as well as N-acetyl-3-hydroxyprocainamide, N-acetylprocainamide-N-oxide and N-acetyl-4- ... aminohippuric acid are also metabolites of procainamide. 4-amino-N-2-(diethylamino)ethyl-benzamide (also known as para-amino-N- ...
... (more precisely, 4-aminomethylbenzoic acid or p-aminomethylbenzoic acid, PAMBA) is an antifibrinolytic ...
... (o-amino-benzoic acid, 2-aminobenzoic acid, 2-AA, 2AA, AA) is an aromatic acid with the formula C6H4(NH2)(CO2H ... tolfenamic acid, flufenamic acid, and meclofenamic acid are derived from fenamic acid or anthranilic acid and are called " ... Fenamic acid is a derivative of anthranilic acid, which in turn is a nitrogen isostere of salicylic acid, which is the active ... Anthranilic acid is biosynthesized from chorismic acid. It is the precursor to the amino acid tryptophan via the attachment of ...
Chorismate is transformed into para-aminobenzoic acid by the enzymes 4-amino-4-deoxychorismate synthase and 4-amino-4- ... 3-Dihydroxybenzoic acid (DHB) used for enterobactin biosynthesis The plant hormone salicylic acid Many alkaloids and other ... The name chorismic acid derives from a classical Greek word, χωρίζω meaning "to separate", because the compound plays a role as ... Chorismic acid, more commonly known as its anionic form chorismate, is an important biochemical intermediate in plants and ...
2-Nitrobenzoic acid is prepared by oxidation of 2-nitrotoluene. 3-Nitrobenzoic acid is a precursor to 3-aminobenzoic acid, ... Nitrobenzoic acid[which?] can be prepared through the oxidation of styrene in boiling nitric acid. The salts and esters of ... Nitrobenzoic acids are derivatives of benzoic acid. Two are commercially important. They are about ten times more acidic than ... It can be prepared by nitration of benzoic acid. It also can be prepared by treating benzaldehyde under nitration conditions, a ...
... including acids such as acetic acid or bases such as pyridine and an excellent solvent for organic substances such as ε- ... caprolactam or benzoic acid and dissolves even some inorganic salts such as silver nitrate or sodium iodide. Due to its ... such as isophthalic acid) and aromatic diamines (such as 1,3-diaminobenzene(m-phenylenediamine)) to aramids such as poly (m- ... A modification of the Koenigs-Knorr reaction for building glycosides from 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide ( ...
34 (4): 1002-1013. doi:10.1002/hlca.19510340404. S. M. McElvain and T. P. Carney, J. Amer. Chem. Soc, 68, 2592 (1946). K. ... 4-Aminobenzoic acid Amino amide Amino esters Anesthesia Anesthetic Brachial plexus block Cocaine analogues: local anesthetics ... Soc, 61, 1713 (1939). Clinton, R. O.; Salvador, U. J.; Laskowski, S. C.; Wilson, Mary (February 1952). "Derivatives of 4-Amino- ... 2-hydroxybenzoic Acid. II". Journal of the American Chemical Society. 74 (3): 592-598. doi:10.1021/ja01123a005. N. Lofgren, C. ...
... also known as para-aminobenzoic acid or PABA, an organic compound Barter Island LRRS Airport (ICAO: PABA). ... the governing body of baseball in the Philippines 4-Aminobenzoic acid, ...
5-di-nitro-benzoic acid and 3,5-di-nitro-salicylic acid". Acta Crystallogr E. 72 (3): 382-386. doi:10.1107/S205698901600267X. ... with the ring-substituted benzoic acid analogues 4-amino-benzoic acid, 3, ...
Widdel, F.; Pfenning, N. (1982). "Studies on Dissimilatory Sulfate-Reducing Bacteria that Decompose Fatty Acids II. Incomplete ... 131 (4): 360-365. doi:10.1007/BF00411187. Lovely, Derek R.; Phillips, Elizabeth J. P. (1994). "Novel processes for anae- robic ... 63 (4): 355-362. doi:10.1002/maco.201005883. ISSN 0947-5117. Kremer, D.R.; Hansen, T.A. (1988). "Pathway of propionate ... Desulfobulbus propionicus strains 1pr3T and 3pr10 can only grow in defined minimal media with the addition of a vitamin 4- ...
"Safety data for p-nitrobenzoic acid". Retrieved 11 April 2010. "p-Nitrobenzoic acid". Archived from the original on 7 May 2010 ... O. Kamm and A. O. Matthews "p-Nitrobenzoic Acid" Org. Synth. 1922, volume 2, p. 53. doi:10.15227/orgsyn.002.0053 "Material ... "Dissociation Constants Of Organic Acids And Bases". Retrieved 11 April 2010. "Bordwell pKa Table (Acidity in DMSO)". Retrieved ... Takao Maki, Kazuo Takeda "Benzoic Acid and Derivatives" in Ullmann's Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, ...
Shikimic acid Davies GM, Barrett-Bee KJ, Jude DA, Lehan M, Nichols WW, Pinder PE, Thain JL, Watkins WJ, Wilson RG (1994). "(6S ... 6S)-6-Fluoroshikimic acid is an antibacterial agent acting on the aromatic biosynthetic pathway. It may be used against ... 6-Fluoro-Shikimic Acid" (pdf). Antimicrobial Agents and Chemotherapy. 39 (1): 87-93. doi:10.1128/AAC.39.1.87. PMC 162490 . PMID ... 6-Fluoroshikimic Acid, an Antibacterial Agent Acting on the Aromatic Biosynthetic Pathway" (pdf). Antimicrobial Agents and ...
... active site by mimicking the substrate para-aminobenzoic acid (PABA).[15] This prevents the substrate itself from binding which ... Bacteria must synthesize folic acid because they do not have a transporter for it. Without folic acid, bacteria cannot grow and ... Substituting equation (5) into equation (4), we have. 0. =. k. 3. [. I. ]. K. m. [. ES. ]. [. S. ]. −. k. −. 3. [. EI. ]. {\ ... These fatty acids inhibitors have been used as drugs to relieve pain because they can act as the substrate, and bind to the ...
Nutritional Health Resource "Para-aminobenzoic acid". Medline Plus Medical Encyclopedia. United States National Institutes of ... Toxicity, Local Anesthetics: eMedicine Emergency Medicine Para-Aminobenzoic acid MS Spectrum PABA Cancer link. ... also known as para-aminobenzoic acid or PABA because the number 4 carbon in the benzene ring is also known as the para position ... "The Sensitization of Near-Ultraviolet Radiation Killing of Mammalian Cells by the Sunscreen Agent Para-aminobenzoic Acid". ...
Other names: Benzoic acid, 4-amino-, tert-butyldimethylsilyl ester; tert-Butyl(dimethyl)silyl 4-aminobenzoate; p-Aminobenzoic ... 4-Aminobenzoic acid, TBDMS derivative. *Formula: C13H21NO2Si ...
... *Formula: C10H15NO2Si ... Other names: Benzoic acid, 4-amino-, trimethylsilyl ester * ... InChI=1S/C10H15NO2Si/c1-14(2,3)13-10(12)8-4-6-9(11)7-5-8/h4-7H,11H2,1-3H3 ...
... amino]benzoic acid 4-7-15(16)17(19)20/h4-5,7-12,18H,2-3, ... amino]benzoic acid 4-7-15(16)17(19)20/h4-5,7-12,18H,2-3,6H2,1H3,(H,19,20)/f/h19H ... post_related( "InChI=1/C17H19NO2/c1-2-3-6-13-9-11-14(12-10-13)18-16-8-5-4-7-15(16)17(19)20/h4-5,7-12,18H,2-3,6H2,1H3,(H,19,20)/ ...
The data comes from registration dossiers submitted to ECHA by the date indicated as last update. The Total Tonnage Band is compiled from all the dossiers with two exceptions; any tonnages claimed confidential and any quantity used as an intermediate to produce a different chemical. The Total Tonnage band published does not necessarily reflect the registered tonnage band(s).. Please note that some of the information on registered substances may belong to third parties. The use of such information may therefore require the prior permission of the third party owners. Please consult the Legal Notice for further information.. ...
... amino]benzoic acid 4-21(5-2)27(25,26)17-12-15(7-6-13(17)3)18(22)20-16-10-8-14(9-11-16)19(23 ... amino]benzoic acid 4-21(5-2)27(25,26)17-12-15(7-6-13(17)3)18(22)20-16-10-8-14(9-11-16)19(23)24/h6-12H,4-5H2,1-3H3,(H ... post_related( "InChI=1/C19H22N2O5S/c1-4-21(5-2)27(25,26)17-12-15(7-6-13(17)3)18(22)20-16-10-8-14(9-11-16)19(23)24/h6-12H,4-5H2, ...
4-Aminobenzoic Acid as Alternative 100G - Please refer to the pdf datasheet for full details of this substance and its ...
... benzoic acid , C15H19NO5 , CID 3589387 - structure, chemical names, physical and chemical properties, classification, patents, ...
AMINO]BENZOIC ACID. Accession Number. DB07114. Type. Small Molecule. Groups. Experimental. Description. Not Available. ... Sulfanilide / Benzoic acid or derivatives / Benzoic acid / Benzoyl / Organic sulfonic acid amide / Organosulfonic acid amide / ... Organosulfonic acid or derivatives / Aminosulfonyl compound / SulfonylMonocarboxylic acid or derivatives / Carboxylic acid / ... Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds / Organooxygen compounds / Organonitrogen ...
... amino]benzoic acid 4-5-6-7-8-11-18-14-16-19(17-15-18)23-21-13-10-9-12-20(21)22(24)25/h9- ... amino]benzoic acid 4-5-6-7-8-11-18-14-16-19(17-15-18)23-21-13-10-9-12-20(21)22(24)25/h9-10,12-17,23H,2-8,11H2,1H3 ... Registries: 4-5-6-7-8-11-18-14-16-19(17-15-18)23-21-13-10-9-12-20(21)22(24)25/h9 ...
... benzoic acid , C14H11NO5 , CID 184285 - structure, chemical names, physical and chemical properties, classification, patents, ...
artificial photosynthesis, aminobenzoic acid, charge transfer, plasmon, induced, plasmon induced, nanostructure, nanostructures ... Artificial photosynthesis - 4-Aminobenzoic acids effect on charge transfer in a photo catalytic system. Moberg, Simon Uppsala ... 4-aminobenzoic acid (pABA). The pABA linker molecule transfers charge from the Ag surface to a semiconductor and a catalyst ... överför foto-exciterade elektroner genom molekyllänken 4-aminobensoesyra (pABA). Molekyllänken pABA överför laddning från ...
... benzoic acid; CAS Number: 1394021-66-9; Linear Formula: C15H13FN2O3; find Combi-Blocks, Inc.-COMH4211A019 MSDS, related peer- ... amino)-benzoic acid. COMH4211A019 Combi-Blocks, Inc.. 2-([(4-Fluoro-phenylcarbamoyl)-methyl]-amino)-benzoic acid. ...
... amino]benzoic acid 4-2-1-3-12(13)15(21)16(19)22/h1- ... amino]benzoic acid 4-2-1-3-12(13)15(21)16(19)22/h1-8H,9H2,(H,18,20)(H,23,24 ... post_related( "InChI=1/C17H12N2O5/c20-14(18-11-7-5-10(6-8-11)17(23)24)9-19-13-4-2-1-3-12(13)15(21)16(19)22/h1-8H,9H2,(H,18,20)( ...
Imides-acid Thiazolidinones-acid Henrys Law Constant (25 deg C) [HENRYWIN v3.10]: Bond Method : 5.02E-017 atm-m3/mole Group ... ino}benzoic acid [ACD/IUPAC Name] Acide 3-{[3-(4-carb. oxybenzyl)-2,4-diox. o-1,3-thiazolidin-5. -yl]amino}benzoïque [French] [ ... Benzoic acid, 3-[[3. -[(4-carboxyphenyl). methyl]-2,4-dioxo-5. -thiazolidinyl]amin. o]- [ACD/Index Name] ... benzoic acid *Molecular FormulaC18H14N2O6S ... 5-yl]amino]benzoic. acid c18h14n2o6s OIYCRSBCZSNDCC-UHFF. ...
7-Aminocephalosporanic acid, 98% (dry wt.), may cont. up to 2% water ...
Calculated speciation curves for (a) 3,5-dnba and (b) 4-aba in methanol. Lines between points have been added as a guide to the ...
... benzoic acid, a product for proteomics research applications, from Santa Cruz. MF: C14H14N2O2, MW: 242.27 ... amino]-benzoic acid *bvseo_sdk, java_sdk, bvseo-3.2.0 ... amino]-benzoic acid MF: C14H14N2O2. MW: 242.27 *Home. ...
Comprehensive supplier list for Benzoic acid, 2-[(7-chloro-4-quinazolinyl)amino]-,Benzoic acid, 2-[(7-chloro-4-quinolinyl)amino ... 5-chlorobenzoic acid, 2-(Carboxymethyl-amino)-5-chloro-benzoic acid, 5-Chloro-2-[(carboxymethyl)amino]benzoic acid Molecular ... Benzoic acid, 2-[(aminosulfonyl)oxy]- (1 supplier). IUPAC Name: 2-sulfamoyloxybenzoic acid , CAS Registry Number: 115438-18-1. ... Benzoic acid, 2-[(8-amino-5-quinolinyl)azo]- (2 suppliers). IUPAC Name: 2-[(8-aminoquinolin-5-yl)diazenyl]benzoic acid , CAS ...
... benzoic acid. We enable science by offering product choice, services, process excellence and our people make it happen. ...
1. 4-Halogeno-5-sulfamylmetanilic acid derivatives. by P. W. Feit et al. ... Aminobenzoic acid diuretics. 1. 4-Halogeno-5-sulfamylmetanilic acid derivatives.. @article{Feit1970AminobenzoicAD, title={ ... Aminobenzoic acid diuretics. 1. 4-Halogeno-5-sulfamylmetanilic acid derivatives.}, author={P. W. Feit and H Bruun and C. ...
4-[[Tetrahydro-2-(3-hydroxy-1-butenyl)-5-oxo-3-furanyl]amino]-benzoic acid, molecular formula: C15H17NO5. ... amino]-benzoic acid. ...
... benzoic acid. We enable science by offering product choice, services, process excellence and our people make it happen. ... 4. Upload files that contain viruses, corrupted files, or any other similar software or programs that may damage the operation ...
The market research report Global 4 Fmoc Amino Benzoic Acid Cas 185116 43 2 Market comprises of market growth, trends, ... fmoc-amino)benzoic acid is $XX million in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million by the ... fmoc-amino)benzoic acid industry. The key insights of the report: 1.The report provides key statistics on the market status of ... fmoc-amino)benzoic acid market. * Product Type I. * Product Type II. * Product Type III. For end use/application segment, this ...
... benzoic acid properties, 4-(Bis-carboxymethyl-amino)-benzoic acidcas no, 4-(Bis-carboxymethyl-amino)-benzoic acid msds,4-(Bis- ... benzoic acid molecular formula, 4-(Bis-carboxymethyl-amino)-benzoic acid density, 4-(Bis-carboxymethyl-amino)- ... Bis-carboxymethyl-amino)-benzoic acid. Description. On Update. Chemical Properties. ChEBI 144223. ...
  • In all these species, methyl salicylate is synthesized by the action of S -adenosyl- l -methionine:salicylic acid carboxyl methyltransferase (SAMT). (plantphysiol.org)
  • Pretreatment of MPO-high leukemia cells with a MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, or a MPO-specific small interfering RNA (siRNA) abrogated the PTL-induced ROS generation and apoptosis, indicating that MPO plays a crucial role in PTL-induced apoptosis in leukemia cells. (aspetjournals.org)
  • In vitro biochemical characterization after bacterial expression revealed three S -adenosyl- l -methionine-dependent methyltransferases with high specificity for anthranilic acid as a substrate. (plantphysiol.org)
  • Of these three proteins, Anthranilic Acid Methyltransferase1 (AAMT1) appears to be responsible for most of the S -adenosyl- l -methionine-dependent methyltransferase activity and methyl anthranilate formation observed in maize after herbivore damage. (plantphysiol.org)
  • Homology-based structural modeling combined with site-directed mutagenesis identified two amino acid residues, designated tyrosine-246 and glutamine-167 in AAMT1, which are responsible for the high specificity of AAMTs toward anthranilic acid. (plantphysiol.org)
  • MLF and citric acid consumption are vital at high ethanol concentrations, as they are the main source for proton extrusion, allowing higher ATP production by F 0 F 1 -ATPase, the main route of ATP synthesis under these conditions. (frontiersin.org)
  • Fakhraee, Synthesis, Characterization and Antibacterial Activity of some Schiff Bases Derived from 4-Aminobenzoic Acid , Asian J. (thefreedictionary.com)
  • A novel electrochemical sensor for sensitive detection of doxepin was prepared, which was based on a glassy carbon electrode modified with poly(4-aminobenzoic acid)/multi-walled carbon nanotubes composite film [poly(4-ABA)/MWNTs/GCE]. (mdpi.com)
  • The signal-off ECL deoxyribosensor was fabricated by covalently coupling the 5'-NH2-(CH2)6-NBAT-Ru to glassy carbon electrode surface modified with 4-aminobenzoic acid (4-ABA). (medworm.com)
  • All Verified acid treated activated carbon suppliers & acid treated activated carbon manufacturers have passed our Business License Check, they can provide quality acid treated activated carbon products. (opencroquet.org)
  • 1. Activated carbon synthetic fiber air filter description Activated carbon fiber (ACF) is a highly efficient adsorbent material with developed microporous structure, heat resistance and acid and alkali resistance. (opencroquet.org)
  • Acid washed briquetted activated carbon is from China professional activated carbon manufacture, is after acid washing and briquetting, with low ash, high hardness and high absorptionis, is primarily to treat surface water sources for the production of. (opencroquet.org)
  • The winemaking of red wines, and of some white wines, involves two fermentation processes: alcoholic fermentation conducted by yeast, and malolactic fermentation (MLF) performed by lactic acid bacteria (LAB). (frontiersin.org)
  • Diazepam loaded Poly Lactic Acid Nanoparticles were developed (D-PLA-NPs) using nanoprecipitation method. (medworm.com)
  • 4-Aminosalicylic acid Maki, T. (wikipedia.org)
  • Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. (rcsb.org)
  • The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. (rcsb.org)
  • 10. The method of claim 6 comprising contacting the organic coated substrate with an acid prior to being thermally treated. (google.com)
  • Bias in dietary reporting of energy and protein intake in relation to percentage body fat, assessed by comparison of data from an interview on dietary intake with data estimated from 24 hour nitrogen output, validated by administering p-aminobenzoic acid, and estimated 24 hour energy expenditure. (bmj.com)