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FAQ4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid: A non-penetrating amino reagent (commonly called SITS) which acts as an inhibitor of anion transport in erythrocytes and other cells.4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid: An inhibitor of anion conductance including band 3-mediated anion transport.Naphthalenesulfonates: A class of organic compounds that contains a naphthalene moiety linked to a sulfonic acid salt or ester.Receptors, Purinergic P2X: A subclass of purinergic P2 receptors that signal by means of a ligand-gated ion channel. They are comprised of three P2X subunits which can be identical (homotrimeric form) or dissimilar (heterotrimeric form).Purinergic P2 Receptor Antagonists: Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).Receptors, Purinergic P2: A class of cell surface receptors for PURINES that prefer ATP or ADP over ADENOSINE. P2 purinergic receptors are widespread in the periphery and in the central and peripheral nervous system.Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt: A colorimetric reagent for iron, manganese, titanium, molybdenum, and complexes of zirconium. (From Merck Index, 11th ed)Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Cefotiam: One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.Acetamides: Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Acetylgalactosamine: The N-acetyl derivative of galactosamine.Spectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Acetylglucosamine: The N-acetyl derivative of glucosamine.Antiporters: Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Carbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Plant Lectins: Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Kinetics: The rate dynamics in chemical or physical systems.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
List of MeSH codes (D02)
... disulfonic acid MeSH D02.455.426.559.389.150.700.550 --- stilbamidines MeSH D02.455.426.559.389.150.700.900 --- tamoxifen MeSH ... isothiocyanatostilbene-2,2'-disulfonic acid MeSH D02.455.426.559.389.150.700.075 --- bibenzyls MeSH D02.455.426.559.389.150. ... edetic acid MeSH D02.241.081.038.455 --- egtazic acid MeSH D02.241.081.038.581 --- iodoacetic acid MeSH D02.241.081.038.581.400 ... muramic acids MeSH D02.241.081.844.562 --- neuraminic acids MeSH D02.241.081.844.562.668 --- sialic acids MeSH D02.241.081.844. ...
Patent US6689563 - System and methods for sequencing by hybridization - Google Patents
The systems and methods described herein also relate to apparatus for sequencing nucleic acids which include gapped probes, as ... and the use of sets of gapped probes in sequencing by hybridization to determine the sequence of nucleic acid sequences. The ... The systems and methods described herein relate to nucleic acid probes comprising a a pattern of universal and designate ... disulfonic acid; pyrene-3-sulfonic acid; 2-toluidinonaphthalene-6-sulfonate; N-phenyl-N-methyl-2-aminoaphthalene-6-sulfonate; ...
http://www.google.com/patents/US6689563?dq=5311516
Tissue Plasminogen Activator
- Alteplase
Summary Report | CureHunter
The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. ... disulfonic Acid (SITS) Related Therapies and Procedures. 1. Thrombolytic Therapy 2. Catheters ... Acetamido- 4'- isothiocyanatostilbene- 2,2'- ... The primary sequence, composed of 527 amino acids, is identical ... Amino Acids, Peptides, and Proteins*Proteins: 90489*Blood Proteins: 4303*Blood Coagulation Factors: 2147*Plasminogen Activators ...
http://www.curehunter.com/public/keywordSummaryD010959.do
Intracellular pH in human arterial smooth muscle. Regulation by Na+/H+ exchange and a novel 5-(N-ethyl-N-isopropyl)amiloride...
... disulfonic acid (SITS), indicating the absence of SITS-sensitive HCO3(-)-dependent mechanisms. Recovery instead appeared mostly ... isothiocyanatostilbene-2,2'- ... using the pH-sensitive dye 2',7'-bis(2-carboxyethyl)-5(6)- ... Recovery of pHi was dependent on extracellular Na+ (Km, 13.1 mM); however, it was not attenuated by 4-acetamido-4'- ...
http://circres.ahajournals.org/content/67/4/814
Plus it
... disulfonic acid known to block Cl- conductances. It is suggested the the voltage-sensitive dye signals recorded from the ... acetamido-4′isothiocyanatostilbene-2,2′- ...
http://www.jneurosci.org/content/16/1/313 Patent US5532129 - Self-organizing molecular photonic structures based on chromophore- and ... - Google Patents
... disulfonic acid, 4-acetamido-4'-isothiocyanato-stilbene-2,2'-disulfonic acid, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic ... disulfonic acid4-acetamido-4'-isothiocyanato- 336 438 Mstilbene-2,2'-disulfonic acid4,4'-Diisothiocyanatostilbene 342 419 M2,2 ... Target nucleic acid sequences to be hybridized in the present methods can be present in any nucleic acid-containing sample so ... For instance, nucleic acids can be isolated from a variety of nucleic acid-containing samples including body tissue, such as ...
http://www.google.com/patents/US5532129?dq=6,788,314
Microbiology Society Journals | Characterization of a haemolytic factor from Candida albicans
... disulfonic acid (DIDS). The haemolysis caused by mannan was inhibited by DIDS, SITS (4-acetamido-4′-isothiocyanatostilbene-2,2 ... disulfonic acid) and bis(sulfosuccinimidyl) suberate, but not by pyridoxal 5-phosphate. These results indicated that a ... isothiocyanatostilbene-2,2′-disulfonic acid) and bis(sulfosuccinimidyl) suberate, but not by pyridoxal 5-phosphate. These ... disulfonic acid (DIDS). The haemolysis caused by mannan was inhibited by DIDS, SITS (4-acetamido-4′- ...
http://mic.microbiologyresearch.org/content/journal/micro/10.1099/13500872-145-3-689
A Large-Conductance Chloride Channel in Pigmented Ciliary Epithelial Cells Activated by GTPγS, The Journal of Membrane Biology ...
... disulfonic acid (DIDS) produced a permanent block. The channel was rarely active in cell-attached patches and usually required ... isothiocyanatostilbene-2,2′-disulfonic acid (SITS), while 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS) produced a ... Add Journal to My Library The Journal of Membrane Biology , Volume 158 (2) - Jul 15, 1997 ... A flickery, reversible block was produced by the diuretic stilbene 4-acetamido-4′-isothiocyanatostilbene-2,2′-disulfonic acid ( ...
https://www.deepdyve.com/lp/springer_journal/a-large-conductance-chloride-channel-in-pigmented-ciliary-epithelial-2apu4YFm6X A Novel Anionic Inward Rectifier in Native Cardiac Myocytes | Circulation Research
The channel is blocked by carboxylic acid derivatives and Cd2+ but is largely unaffected by disulfonic stilbene derivatives and ... isothiocyanatostilbene-2,2′-disulfonic acid (SITS) have been identified as effective blockers of a variety of cardiac5 38 39 ... Several compounds including arylaminoalkyl benzoates derivatives such as 9-anthracene-carboxylic acid (9-AC) and disulfonic ... A, Carboxylic acid derivative 9-AC blocked ICl.ir in mouse atrial myocytes. A-a, Mean I-V curves of ICl.ir obtained from 4 ...
http://circres.ahajournals.org/content/86/4/e63
NAVER Academic > Search...
Disulfonic Acid, 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid, analogs & derivatives, pharmacology, Animals, ... 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Cell Count, Cell Survival, drug effects, Mice, Mice, Inbred C57BL, ... start page previous page 1 2 3 4 5 next page end page ... 41 results for 'Journal of neuroscience research 30권 4호' * ...
https://academic.naver.com/search.naver?field=3&query=Journal+of+neuroscience+research+30%EA%B6%8C+4%ED%98%B8 NAVER Academic > Search...
Disulfonic Acid, 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid, analogs & derivatives, pharmacology, Anion ... Formation of alpha-tocopherol complexes with fatty acids. Nature of complexes.. 1985 A N Erin et al. Biochimica et biophysica ... Fatty Acids, Hydrogen Bonding, Magnetic Resonance Spectroscopy, Models, Molecular, Spectrophotometry, Ultraviolet, Temperature ... Adaptation, Physiological, Calorimetry, Cell Membrane, physiology, Fatty Acids, Fluorescence Polarization, Geobacillus ...
https://academic.naver.com/search.naver?field=3&query=Biochimica+et+Biophysica+Acta+815%EA%B6%8C+2%ED%98%B8 Patent US7179423 - Microfluidic system including a virtual wall fluid interface port for ... - Google Patents
... disulfonic acid; pyrene-3-sulfonic acid; 2-toluidinonaphthalene-6-sulfonate; N-phenyl-N-methyl-2-aminoaphthalene-6-sulfonate; ... Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid ... Integrated nucleic acid diagnostic device. US6213151. 25 Apr 2000. 10 Apr 2001. Ut-Battelle, Llc. Microfluidic circuit designs ... In some cases, the amino acid tryptophan, which is either part of a peptide or protein of interest (i.e., it is endogenous to ...
http://www.google.com.au/patents/US7179423 US7238792B2 - Foldable polymers as probes
- Google Patents
... disulfonic acid, acridine and its derivatives such as acridine isothiocyanate, 5-(2′-aminoethyl)aminonaphthalene-1-sulfonic ... isothiocyanatostilbene-2,2′- ... context of nucleic acid-nucleic acid and protein-nucleic acid ... 107 amino acid, ˜11.7 kDa), HMGA1b (96 amino acid, ˜10.6 kDa), and HMGA2 (109 amino acid, ˜12 kDa), are known as architectural ... Detection of the products on TLC plates was accomplished using sulfuric acid solution (25.0 mL of conc. sulfuric acid, 12.6 g ...
https://patents.google.com/patent/US7238792B2/en
Iron homeostasis in the lung
... disulfonic acid (DIDS) or 4-acetamido-4'-isothiocyanatostilbene-2,2'disulfonic acid (SITS). Ten min later, 100 μM FAC was added ... The supernatant was removed and 1.0 mL 3 N HCl with 10% trichloroacetic acid added. The cells were scraped into the acid and ... trichloroacetic acid, and hydrolyzed at 70o C for 18 h. Iron was measured using ICPAES (_ 238.204). Cells treated with AS-4 ... trichloroacetic acid, and hydrolyzed at 70ºC for 18 h. Iron was then measured using ICPAESλ = 238.204). Both DIDS and SITS ...
https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100008&lng=en&nrm=iso&tlng=en
Toronto Research Chemicals | Page 6
... disulfonic Acid, Sodium Salt CAS number: 51023-76-8 Alternate CAS: Free Acid: 27816-59-7 ... O-(5-Acetamido-4,7,8,9-tetra-O-acetyl-3-thiophenyl-α-neuraminosyl Methyl Ester)-2-α-3-O-(6-O-benzyl-β-D-galactopyranosyl)-1-β-4 ... isothiocyanatostilbene-2,2'- ... Acexamic Acid; CY 153; N-Acetyl-6-aminohexanoic Acid; AACA; N- ... 6-(Acetylamino)hexanoic Acid; 6-Acetamidocaproic Acid; Acemin; Acetaminocaproic Acid; ...
https://www.trc-canada.com/products-listing/6/
Search Articles | University of Toronto Libraries
... disulfonic acid - pharmacology (38) 38 Filter by. Remove filter. female (37) 37 ... isothiocyanatostilbene-2,2'-disulfonic acid - pharmacology (25) 25 Filter by. Remove filter. na (25) 25 ... Topiramate , epileptiform activity , HCO , neuronal pH , carbonic anhydrase inhibitor , exchanger , independent Cl , ACID ... epileptiform activity , exchange , intracellular pH , HCO , dependent Cl , Levetiracetam , ACID EXTRUSION , BIOELECTRIC ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:CL-HCO3%20EXCHANGE
Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. - PubMed - NCBI
... disulfonic Acid/analogs & derivatives. *4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid/pharmacology ... isothiocyanatostilbene-2,2'- ... the specific band 3 anion channel blocking agents niflumic acid ... molecules.mu-2.s-1 was calculated. The hypoxia induced ATP release was blocked in three different ways: first, by application ...
https://www.ncbi.nlm.nih.gov/pubmed/1325292?dopt=Abstract Patent US8497064 - Nucleic acid labelling compounds - Google Patents
The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a ... Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a ... disulfonic acid; pyrene-3-sulfonic acid; 2-toluidinonapththalene-6-sulfonate; N-phenyl, N-methyl 2-aminonaphthalene-6-sulfonate ... attaching at least one nucleic acid to a support; and. coupling the at least one nucleic acid to the nucleic acid labeling ...
http://www.google.com.au/patents/US8497064 Intravenous Thrombolysis for Ischemic Stroke Patients on Dual Antiplatelets<...
2 (0‐4); 95%CI:‐0.29,0.09] were documented between the two groups.. Interpretation. Given that patients on dual antiplatelet ... 2 (0‐4); 95{\%}CI:‐0.29,0.09] were documented between the two groups.InterpretationGiven that patients on dual antiplatelet ... 2 (0‐4); 95%CI:‐0.29,0.09] were documented between the two groups.InterpretationGiven that patients on dual antiplatelet ... 2 (0‐4); 95%CI:‐0.29,0.09] were documented between the two groups.InterpretationGiven that patients on dual antiplatelet ...
https://abdn.pure.elsevier.com/en/publications/intravenous-thrombolysis-for-ischemic-stroke-patients-on-dual-ant
The regulated release of transmitters from astrocytes | Springer for Research & Development
... disulfonic acid. SD. Spreading depression. SITS. 4-acetamido-4′-isothiocyanato-stilbene-2,2′-disulfonate ... Seal RP, Amara SG (1999) Excitatory amino acid transporters: a family in flux. Annu Rev Pharmacol Toxicol 39:431-456.PubMed ... Maycox PR, Hell JW, Jahn R (1990) Amino acid neurotransmission: spotlight on synaptic vesicles. Trends Neurosci 13:83-87.PubMed ... Duan S, Anderson CM, Keung EC, Chen Y, Swanson RA (2003) P2X7 receptor-mediated release of excitatory amino acids from ...
https://rd.springer.com/chapter/10.1007/978-1-4020-7937-5_16
VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE-ENHANCED RAMAN NANOPARTICLE TAGS - Patent application
... disulfonic acid, disodium salt; 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid, disodium salt; N-(4-(6-dimethylamino-2- ... isothiocyanatostilbene-2,2'-disulfonic acid, disodium salt; benzophenone-4-isothiocyanate; 4,4'-diisothiocyanatodihydrostilbene ... nucleic acids (both monomeric and oligomeric), polysaccharides, sugars, fatty acids, steroids, purines, pyrimidines, drugs (e.g ... 0075] The term "nucleic acid" as used herein refers to DNA and RNA, whether isolated from nature, of viral, bacterial, plant or ...
http://www.patentsencyclopedia.com/app/20130149247
- We investigated in a physiological salt solution (PSS) containing HCO3- the intracellular pH (pHi) regulating mechanisms in smooth muscle cells cultured from human internal mammary arteries, using the pH-sensitive dye 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) and 22Na+ influx rates. (ahajournals.org)