4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Naphthalenesulfonates
Receptors, Purinergic P2X
Purinergic P2 Receptor Antagonists
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Receptors, Purinergic P2
Suramin
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
Hydrogen-Ion Concentration
Adenosine Triphosphate
Bicarbonates
Antiporters
Biological Transport
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
List of MeSH codes (D02)
... disulfonic acid MeSH D02.455.426.559.389.150.700.075 - bibenzyls MeSH D02.455.426.559.389.150.700.100 - chlorotrianisene MeSH ... diisothiocyanostilbene-2,2'-disulfonic acid MeSH D02.455.426.559.389.150.700.550 - stilbamidines MeSH D02.455.426.559.389.150. ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ...
PMID- 21949453
Disulfonic Acid) RN - 950-99-2 (2,2,5,7,8-pentamethyl-1-hydroxychroman) SB - IM MH - 4,4-Diisothiocyanostilbene-2,2- ... Diisothiocyanostilbene-2,2- ... Disulfonic Acid MH - Action Potentials/*physiology MH - Animals ... Fatty Acids, Omega-3) RN - 0 (Plant Oils) RN - 1553-41-9 (Eicosapentaenoic Acid) RN - 25167-62-8 (Docosahexaenoic Acids) RN - ... Docosahexaenoic Acids/analysis/blood MH - Eicosapentaenoic Acid/analysis/blood MH - Electrocardiography MH - Fatty Acids, Omega ...
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Mechanisms of acid secretion in pseudobranch cells of rainbow trout(Oncorhynchus mykiss) | Journal of Experimental Biology |...
Mechanisms of acid secretion in pseudobranch cells of rainbow trout(Oncorhynchus mykiss) G. Kern, G. Kern ... reduced the rate of acid secretion by about 10% under control conditions, while no effect of bafilomycin on the rate of acid ... The rate of acid release (acidification rate in μV s-1) was quantified by fitting the sensor data collected during periods of ... The effect of amiloride, an inhibitor of Na+/H+-exchange, on the rate of acidification of the external medium induced by acid ...
Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate...
... disulfonic acid (DIDS) inhibited the methotrexate accumulation markedly. These findings suggest that the rat OAT-KI is ... diisothiocyanostilbene-2,2-disulfonic acid (DIDS) inhibited the methotrexate accumulation markedly. These findings suggest ... disulfonic acid (DIDS) inhibited the methotrexate accumulation markedly. These findings suggest that the rat OAT-KI is ... disulfonic acid (DIDS) inhibited the methotrexate accumulation markedly. These findings suggest that the rat OAT-KI is ...
Publikationen | Max-Planck-Institut für Biophysik
Kaplan, J. H.; Scorah, K.; Fasold, H.; Passow, H.: Sidedness of the inhibitory action of disulfonic acids on chloride ... diisothiocyano stilbene-2,2′-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). Journal of Membrane Biology 29 (1), S ... Hopfer, U.; Sigrist‐Nelson, K.; Ammann, E.; Murer, H.: Differences in neutral amino acid and glucose transport between brush ... Berner, W.; Kinne, R.: Transport of p-aminohippuric acid by plasma membrane vesicles isolated from rat kidney cortex. Pflügers ...
Volume-associated osmolyte fluxes in cell lines with or without the anion exchanger
... disulfonic acid] were potent inhibitors of amino acid efflux in the three cell lines. 125I efflux, used as a marker for Cl- ... diisothiocyanostilbene-2,2- ... amino acid efflux and suggest that amino acids and Cl- may be ... To investigate the involvement of a red cell-type anion exchanger in the volume-sensitive amino acid release, the hyposmolarity ... Blockers of the anion exchanger and/or Cl- channels [niflumic acid, dipyridamole, diphenylamine-2-carboxylate, 5-nitro-2-(3- ...
Binding properties of the stilbene disulfonate sites on human erythrocyte AE1: kinetic, thermodynamic, and solid state...
... disulfonic acid (DIDS), a highly specific inhibitor of AE1. Inhibition of sulfate equilibrium exchange by TIDS in whole cells ... disulfonic acid (TIDS), has been chemically synthesized, and the interaction of this probe with human erythrocyte anion ... Solid state (2)H NMR analysis of a [N(+)(CD(3))(3)]TIDS-AE1 complex in both unoriented and macroscopically oriented membranes ... Following proteolysis, (1.2 +/- 0.4) x 10(6) TIDS binding sites per erythrocyte could be blocked by prior treatment with 4,4- ...
Functional expression of a truncated Ca(2+)-activated Cl- channel and activation by phorbol ester.
Disulfonic Acid, Animals, Calcium, Calcium Channels, Chlorides, Dithiothreitol, Electrophysiology, Flufenamic Acid, In Vitro ... diisothiocyanostilbene-2,2-disulfonic acid and dithiothreitol. Whole cell currents in wtCaCC- and CaCCX-expressing oocytes ... We have isolated a niflumic acid-insensitive, Ca(2+)-activated Cl- channel (CaCC) from bovine trachea that migrates at 38 kDa ( ... Techniques, Ion Channel Gating, Ionophores, Molecular Weight, Mutagenesis, Site-Directed, Niflumic Acid, Oocytes, Open Reading ...
Shohei Ikoma | USC Profiles
DeCS 2013 - December 17, 2013 version
Disulfonic Acid 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine ... Diisothiocyanostilbene-2,2- ... 6-Aminocaproic Acid use Aminocaproic Acid 6-Aminohexanoic Acid ... 99mTc-Dimercaptosuccinic Acid use Technetium Tc 99m Dimercaptosuccinic Acid 99mTc-DMSA use Technetium Tc 99m Dimercaptosuccinic ... 12-S-HETE use 12-Hydroxy-5.8,10,14-eicosatetraenoic Acid 12-S-Hydroxyeicosatetraenoic Acid use 12-Hydroxy-5.8,10,14- ...
Jeffrey J. Wine's Profile | Stanford Profiles
... disulfonic acid (DNDS), or calixarene but was reduced 77 +/- 18% by N-phenylanthranilic acid. Three transport mechanisms ... diisothiocyanostilbene-2,2-disulfonic acid (DIDS), 4,4-dinitrostilbene-2,2-disulfonic acid, and calixarene. Isc was measured ... disulfonic acid (DNDS) had no effect. The increase in Isc produced by DIDS represents Cl- secretion and appears to result from ... disulfonic acid (SITS) to T84 monolayers produced a transient increase in short-circuit current (Isc), followed by a sustained ...
DeCS 2009 - February 20, 2009 version
Disulfonic Acid 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine ... Diisothiocyanostilbene-2,2- ... 12-R-HETE use 12-Hydroxy-5.8,10,14-eicosatetraenoic Acid 12-S- ... 99mTc-Dimercaptosuccinic Acid use Technetium Tc 99m Dimercaptosuccinic Acid 99mTc-DMSA use Technetium Tc 99m Dimercaptosuccinic ... 12-S-Hydroxyeicosatetraenoic Acid use 12-Hydroxy-5.8,10,14-eicosatetraenoic Acid ...
DIDS2
- A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4′-diisothiocyano stilbene-2,2′-disulfonic acid (DIDS) and its dihydro derivative (H 2 DIDS). (mpg.de)
- Following proteolysis, (1.2 +/- 0.4) x 10(6) TIDS binding sites per erythrocyte could be blocked by prior treatment with 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), a highly specific inhibitor of AE1. (ox.ac.uk)
Niflumic acid2
- Blockers of the anion exchanger and/or Cl- channels [niflumic acid, dipyridamole, diphenylamine-2-carboxylate, 5-nitro-2-(3-phenylpropylamino)- benzoic acid, and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid] were potent inhibitors of amino acid efflux in the three cell lines. (uab.edu)
- We have isolated a niflumic acid-insensitive, Ca(2+)-activated Cl- channel (CaCC) from bovine trachea that migrates at 38 kDa (p38) on reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. (uab.edu)
Amino acid4
- The rat OAT-K1 cDNA (2788 base pairs) had an open reading frame encoding for a 669-amino acid protein (calculated molecular mass of 74 kDa) which shows 72% identity with the cloned rat liver organic anion transporter, oatp. (elsevier.com)
- Differences in neutral amino acid and glucose transport between brush border and basolateral plasma membrane of intestinal epithelial cells. (mpg.de)
- All cell types accumulated D-[3H]aspartate and [3H]taurine under isosmotic conditions, and, similarly, in the three cell lines, cell swelling evoked by hyposmolarity induced a rapid and transient increase in the amino acid efflux. (uab.edu)
- These results do not support a role for an anion exchanger in the hyposmolarity-induced amino acid efflux and suggest that amino acids and Cl- may be transported by the same or a similar mechanism, presumably an anion channel-like structure. (uab.edu)
Transport1
- Sidedness of the inhibitory action of disulfonic acids on chloride equilibrium exchange and net transport across the human erythrocyte membrane. (mpg.de)
Cells3
- Using a cytosensor microphysiometer, the rate of acid secretion of these cells was measured and compared with the activity of a gill cell preparation. (biologists.com)
- Incubation of pseudobranch cells with bafilomycin A1 (10 -6 moll -1 ), a specific inhibitor of V-ATPase, reduced the rate of acid secretion by about 10% under control conditions, while no effect of bafilomycin on the rate of acid secretion of gill cells was observed. (biologists.com)
- Application of amiloride (5×10 -5 moll -1 ) reduced the rate of acid secretion in cells of both organs,pseudobranch and gills. (biologists.com)