A non-penetrating amino reagent (commonly called SITS) which acts as an inhibitor of anion transport in erythrocytes and other cells.
An inhibitor of anion conductance including band 3-mediated anion transport.
A class of organic compounds that contains a naphthalene moiety linked to a sulfonic acid salt or ester.
A subclass of purinergic P2 receptors that signal by means of a ligand-gated ion channel. They are comprised of three P2X subunits which can be identical (homotrimeric form) or dissimilar (heterotrimeric form).
Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
A class of cell surface receptors for PURINES that prefer ATP or ADP over ADENOSINE. P2 purinergic receptors are widespread in the periphery and in the central and peripheral nervous system.
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
A colorimetric reagent for iron, manganese, titanium, molybdenum, and complexes of zirconium. (From Merck Index, 11th ed)
Organic compounds that contain 1,2-diphenylethylene as a functional group.
Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid is a chemical compound that is often used in research and scientific studies. It is a type of stilbene derivative, which is a class of compounds characterized by the presence of a central double bond flanked by two phenyl rings.

In this particular compound, one of the phenyl rings has been substituted with an acetamido group (-NH-C(=O)CH3), while the other phenyl ring has been substituted with an isothiocyanato group (-N=C=S) and two sulfonic acid groups (-SO3H).

The compound is often used as a fluorescent probe in biochemical and cellular studies, as it exhibits strong fluorescence when bound to certain proteins or other biological molecules. It can be used to study the interactions between these molecules and to investigate their structure and function.

It's important to note that this compound is not approved for medical use in humans and should only be handled by trained professionals in a controlled laboratory setting.

'4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid' is a chemical compound that is often used in research and scientific studies. Its molecular formula is C14H10N2O6S2. This compound is a derivative of stilbene, which is a type of organic compound that consists of two phenyl rings joined by a ethylene bridge. In '4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid', the hydrogen atoms on the carbon atoms of the ethylene bridge have been replaced with isothiocyanate groups (-N=C=S), and the phenyl rings have been sulfonated (introduction of a sulfuric acid group, -SO3H) to increase its water solubility.

This compound is often used as a fluorescent probe in biochemical and cell biological studies due to its ability to form covalent bonds with primary amines, such as those found on proteins. This property allows researchers to label and track specific proteins or to measure the concentration of free primary amines in a sample.

It is important to note that '4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid' is a hazardous chemical and should be handled with care, using appropriate personal protective equipment and safety measures.

Naphthalenesulfonates are a group of chemical compounds that consist of a naphthalene ring, which is a bicyclic aromatic hydrocarbon, substituted with one or more sulfonate groups. Sulfonates are salts or esters of sulfuric acid. Naphthalenesulfonates are commonly used as detergents, dyes, and research chemicals.

In the medical field, naphthalenesulfonates may be used in diagnostic tests to detect certain enzyme activities or metabolic disorders. For example, 1-naphthyl sulfate is a substrate for the enzyme arylsulfatase A, which is deficient in individuals with the genetic disorder metachromatic leukodystrophy. By measuring the activity of this enzyme using 1-naphthyl sulfate as a substrate, doctors can diagnose or monitor the progression of this disease.

It's worth noting that some naphthalenesulfonates have been found to have potential health hazards and environmental concerns. For instance, sodium naphthalenesulfonate has been classified as a possible human carcinogen by the International Agency for Research on Cancer (IARC). Therefore, their use should be handled with caution and in accordance with established safety protocols.

Purinergic P2X receptors are a type of ligand-gated ion channel that are activated by the binding of extracellular ATP (adenosine triphosphate) and other purinergic agonists. These receptors play important roles in various physiological processes, including neurotransmission, pain perception, and immune response.

P2X receptors are composed of three subunits that form a functional ion channel. There are seven different subunits (P2X1-7) that can assemble to form homo- or heterotrimeric receptor complexes with distinct functional properties.

Upon activation by ATP, P2X receptors undergo conformational changes that allow for the flow of cations, such as calcium (Ca^2+^), sodium (Na^+^), and potassium (K^+^) ions, across the cell membrane. This ion flux can lead to a variety of downstream signaling events, including the activation of second messenger systems and changes in gene expression.

Purinergic P2X receptors have been implicated in a number of pathological conditions, including chronic pain, inflammation, and neurodegenerative diseases. As such, they are an active area of research for the development of novel therapeutic strategies.

Purinergic P2 receptor antagonists are pharmaceutical agents that block the activity of P2 receptors, which are a type of cell surface receptor that binds extracellular nucleotides such as ATP and ADP. These receptors play important roles in various physiological processes, including neurotransmission, inflammation, and platelet aggregation.

P2 receptors are divided into two main subfamilies: P2X and P2Y. The P2X receptors are ligand-gated ion channels that allow the flow of ions across the cell membrane upon activation, while the P2Y receptors are G protein-coupled receptors that activate intracellular signaling pathways.

Purinergic P2 receptor antagonists are used in clinical medicine to treat various conditions, such as chronic pain, urinary incontinence, and cardiovascular diseases. For example, the P2X3 receptor antagonist gefapixant is being investigated for the treatment of refractory chronic cough, while the P2Y12 receptor antagonists clopidogrel and ticagrelor are used to prevent thrombosis in patients with acute coronary syndrome.

Overall, purinergic P2 receptor antagonists offer a promising therapeutic approach for various diseases by targeting specific receptors involved in pathological processes.

Pyridoxal phosphate (PLP) is the active form of vitamin B6 and functions as a cofactor in various enzymatic reactions in the human body. It plays a crucial role in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Pyridoxal phosphate is involved in more than 140 different enzyme-catalyzed reactions, making it one of the most versatile cofactors in human biochemistry.

As a cofactor, pyridoxal phosphate helps enzymes carry out their functions by facilitating chemical transformations in substrates (the molecules on which enzymes act). In particular, PLP is essential for transamination, decarboxylation, racemization, and elimination reactions involving amino acids. These processes are vital for the synthesis and degradation of amino acids, neurotransmitters, hemoglobin, and other crucial molecules in the body.

Pyridoxal phosphate is formed from the conversion of pyridoxal (a form of vitamin B6) by the enzyme pyridoxal kinase, using ATP as a phosphate donor. The human body obtains vitamin B6 through dietary sources such as whole grains, legumes, vegetables, nuts, and animal products like poultry, fish, and pork. It is essential to maintain adequate levels of pyridoxal phosphate for optimal enzymatic function and overall health.

Purinergic P2 receptors are a type of cell surface receptor that bind to purine nucleotides and nucleosides, such as ATP (adenosine triphosphate) and ADP (adenosine diphosphate), and mediate various physiological responses. These receptors are divided into two main families: P2X and P2Y.

P2X receptors are ionotropic receptors, meaning they form ion channels that allow the flow of ions across the cell membrane upon activation. There are seven subtypes of P2X receptors (P2X1-7), each with distinct functional and pharmacological properties.

P2Y receptors, on the other hand, are metabotropic receptors, meaning they activate intracellular signaling pathways through G proteins. There are eight subtypes of P2Y receptors (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14), each with different G protein coupling specificities and downstream signaling pathways.

Purinergic P2 receptors are widely expressed in various tissues, including the nervous system, cardiovascular system, respiratory system, gastrointestinal tract, and immune system. They play important roles in regulating physiological functions such as neurotransmission, vasodilation, platelet aggregation, smooth muscle contraction, and inflammation. Dysregulation of purinergic P2 receptors has been implicated in various pathological conditions, including pain, ischemia, hypertension, atherosclerosis, and cancer.

Suramin is a medication that has been used for the treatment of African sleeping sickness, which is caused by trypanosomes. It works as a reverse-specific protein kinase CK inhibitor and also blocks the attachment of the parasite to the host cells. Suramin is not absorbed well from the gastrointestinal tract and is administered intravenously.

It should be noted that Suramin is an experimental treatment for other conditions such as cancer, neurodegenerative diseases, viral infections and autoimmune diseases, but it's still under investigation and has not been approved by FDA for those uses.

1,2-Dihydroxybenzene-3,5-disulfonic acid disodium salt is a chemical compound with the formula Na2C6H4O6S2. It is also known as pyrocatechol-3,5-disulfonic acid disodium salt or sodium salt of 1,2-dihydroxybenzene-3,5-disulfonic acid.

This compound is a white crystalline powder that is soluble in water and has a variety of uses in the chemical industry. It can be used as a reducing agent, a chelating agent, and a developer in photographic processes. It may also have potential applications in the medical field, such as in the treatment of heavy metal poisoning, although more research is needed to confirm its effectiveness and safety for this use.

It's important to note that while 1,2-Dihydroxybenzene-3,5-disulfonic acid disodium salt may have various applications, it should be handled with care and used under appropriate conditions, as with any chemical compound.

Stilbenes are a type of chemical compound that consists of a 1,2-diphenylethylene backbone. They are phenolic compounds and can be found in various plants, where they play a role in the defense against pathogens and stress conditions. Some stilbenes have been studied for their potential health benefits, including their antioxidant and anti-inflammatory effects. One well-known example of a stilbene is resveratrol, which is found in the skin of grapes and in red wine.

It's important to note that while some stilbenes have been shown to have potential health benefits in laboratory studies, more research is needed to determine their safety and effectiveness in humans. It's always a good idea to talk to a healthcare provider before starting any new supplement regimen.

Chlorides are simple inorganic ions consisting of a single chlorine atom bonded to a single charged hydrogen ion (H+). Chloride is the most abundant anion (negatively charged ion) in the extracellular fluid in the human body. The normal range for chloride concentration in the blood is typically between 96-106 milliequivalents per liter (mEq/L).

Chlorides play a crucial role in maintaining electrical neutrality, acid-base balance, and osmotic pressure in the body. They are also essential for various physiological processes such as nerve impulse transmission, maintenance of membrane potentials, and digestion (as hydrochloric acid in the stomach).

Chloride levels can be affected by several factors, including diet, hydration status, kidney function, and certain medical conditions. Increased or decreased chloride levels can indicate various disorders, such as dehydration, kidney disease, Addison's disease, or diabetes insipidus. Therefore, monitoring chloride levels is essential for assessing a person's overall health and diagnosing potential medical issues.

Hydrogen-ion concentration, also known as pH, is a measure of the acidity or basicity of a solution. It is defined as the negative logarithm (to the base 10) of the hydrogen ion activity in a solution. The standard unit of measurement is the pH unit. A pH of 7 is neutral, less than 7 is acidic, and greater than 7 is basic.

In medical terms, hydrogen-ion concentration is important for maintaining homeostasis within the body. For example, in the stomach, a high hydrogen-ion concentration (low pH) is necessary for the digestion of food. However, in other parts of the body such as blood, a high hydrogen-ion concentration can be harmful and lead to acidosis. Conversely, a low hydrogen-ion concentration (high pH) in the blood can lead to alkalosis. Both acidosis and alkalosis can have serious consequences on various organ systems if not corrected.

Adenosine Triphosphate (ATP) is a high-energy molecule that stores and transports energy within cells. It is the main source of energy for most cellular processes, including muscle contraction, nerve impulse transmission, and protein synthesis. ATP is composed of a base (adenine), a sugar (ribose), and three phosphate groups. The bonds between these phosphate groups contain a significant amount of energy, which can be released when the bond between the second and third phosphate group is broken, resulting in the formation of adenosine diphosphate (ADP) and inorganic phosphate. This process is known as hydrolysis and can be catalyzed by various enzymes to drive a wide range of cellular functions. ATP can also be regenerated from ADP through various metabolic pathways, such as oxidative phosphorylation or substrate-level phosphorylation, allowing for the continuous supply of energy to cells.

Bicarbonates, also known as sodium bicarbonate or baking soda, is a chemical compound with the formula NaHCO3. In the context of medical definitions, bicarbonates refer to the bicarbonate ion (HCO3-), which is an important buffer in the body that helps maintain normal pH levels in blood and other bodily fluids.

The balance of bicarbonate and carbonic acid in the body helps regulate the acidity or alkalinity of the blood, a condition known as pH balance. Bicarbonates are produced by the body and are also found in some foods and drinking water. They work to neutralize excess acid in the body and help maintain the normal pH range of 7.35 to 7.45.

In medical testing, bicarbonate levels may be measured as part of an electrolyte panel or as a component of arterial blood gas (ABG) analysis. Low bicarbonate levels can indicate metabolic acidosis, while high levels can indicate metabolic alkalosis. Both conditions can have serious consequences if not treated promptly and appropriately.

Antiporters, also known as exchange transporters, are a type of membrane transport protein that facilitate the exchange of two or more ions or molecules across a biological membrane in opposite directions. They allow for the movement of one type of ion or molecule into a cell while simultaneously moving another type out of the cell. This process is driven by the concentration gradient of one or both of the substances being transported. Antiporters play important roles in various physiological processes, including maintaining electrochemical balance and regulating pH levels within cells.

Biological transport refers to the movement of molecules, ions, or solutes across biological membranes or through cells in living organisms. This process is essential for maintaining homeostasis, regulating cellular functions, and enabling communication between cells. There are two main types of biological transport: passive transport and active transport.

Passive transport does not require the input of energy and includes:

1. Diffusion: The random movement of molecules from an area of high concentration to an area of low concentration until equilibrium is reached.
2. Osmosis: The diffusion of solvent molecules (usually water) across a semi-permeable membrane from an area of lower solute concentration to an area of higher solute concentration.
3. Facilitated diffusion: The assisted passage of polar or charged substances through protein channels or carriers in the cell membrane, which increases the rate of diffusion without consuming energy.

Active transport requires the input of energy (in the form of ATP) and includes:

1. Primary active transport: The direct use of ATP to move molecules against their concentration gradient, often driven by specific transport proteins called pumps.
2. Secondary active transport: The coupling of the movement of one substance down its electrochemical gradient with the uphill transport of another substance, mediated by a shared transport protein. This process is also known as co-transport or counter-transport.

Membrane potential is the electrical potential difference across a cell membrane, typically for excitable cells such as nerve and muscle cells. It is the difference in electric charge between the inside and outside of a cell, created by the selective permeability of the cell membrane to different ions. The resting membrane potential of a typical animal cell is around -70 mV, with the interior being negative relative to the exterior. This potential is generated and maintained by the active transport of ions across the membrane, primarily through the action of the sodium-potassium pump. Membrane potentials play a crucial role in many physiological processes, including the transmission of nerve impulses and the contraction of muscle cells.

Calcium is an essential mineral that is vital for various physiological processes in the human body. The medical definition of calcium is as follows:

Calcium (Ca2+) is a crucial cation and the most abundant mineral in the human body, with approximately 99% of it found in bones and teeth. It plays a vital role in maintaining structural integrity, nerve impulse transmission, muscle contraction, hormonal secretion, blood coagulation, and enzyme activation.

Calcium homeostasis is tightly regulated through the interplay of several hormones, including parathyroid hormone (PTH), calcitonin, and vitamin D. Dietary calcium intake, absorption, and excretion are also critical factors in maintaining optimal calcium levels in the body.

Hypocalcemia refers to low serum calcium levels, while hypercalcemia indicates high serum calcium levels. Both conditions can have detrimental effects on various organ systems and require medical intervention to correct.

... disulfonic acid MeSH D02.455.426.559.389.150.700.075 - bibenzyls MeSH D02.455.426.559.389.150.700.100 - chlorotrianisene MeSH ... diisothiocyanostilbene-2,2'-disulfonic acid MeSH D02.455.426.559.389.150.700.550 - stilbamidines MeSH D02.455.426.559.389.150. ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ...
... disulfonic acid (DIDS) inhibited these pHi responses to a reduction of bath HCO3-, Cl-, or Na+, and an alkali loading. Our ... Diisothiocyanostilbene-2,2- ... NH3 efflux causes H+ to be released from NH+4 in the lumen). ... Renal cortex was obtained from rats fed either a 0.03% (-P) or a 0.6% (+P) Pi diet for 4 h or 7 days, and BBM were prepared. Na ... The increment in [3H]MI is observed at 37 degrees C but not at 4 degrees C. MI uptake is Na+ dependent in cells grown both in ...
DISULFONIC ACID. DOM. 2,5-DIMETHOXY-4-METHYLAMPHETAMINE. EIMERIINA. EIMERIIDA. EPN. PHENYLPHOSPHONOTHIOIC ACID, 2-ETHYL 2-(4- ... DIISOTHIOCYANOSTILBENE-2,2- ...
DISULFONIC ACID. DOM. 2,5-DIMETHOXY-4-METHYLAMPHETAMINE. EIMERIINA. EIMERIIDA. EPN. PHENYLPHOSPHONOTHIOIC ACID, 2-ETHYL 2-(4- ... DIISOTHIOCYANOSTILBENE-2,2- ...
DISULFONIC ACID. DOM. 2,5-DIMETHOXY-4-METHYLAMPHETAMINE. EIMERIINA. EIMERIIDA. EPN. PHENYLPHOSPHONOTHIOIC ACID, 2-ETHYL 2-(4- ... DIISOTHIOCYANOSTILBENE-2,2- ...
CA: cholic acid, CDCA: chenodeoxycholic acid, DCA: deoxycholic acid, GCA: glycocholic acid, GDCA: glycodeoxycholic acid, GCDCA ... glycochenodeoxycholic acid, TCA: taurocholic acid, TCDCA: taurochenodeoxycholic acid, TDCA: taurodeoxycholic acid. ... Secondary bile acids such as deoxycholic acid (DCA) and lithocholic acid (LCA) are produced in the colon by bacterial ... Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1. Biochem Biophys Res Commun 367(1): 208-212 ...
Disulfonic Acid. *4-Acetamido-4-isothiocyanatostilbene-2,2-disulfonic Acid. *Bibenzyls ... Diisothiocyanostilbene-2,2- ...
... disulfonic acid MeSH D02.455.426.559.389.150.700.075 - bibenzyls MeSH D02.455.426.559.389.150.700.100 - chlorotrianisene MeSH ... diisothiocyanostilbene-2,2-disulfonic acid MeSH D02.455.426.559.389.150.700.550 - stilbamidines MeSH D02.455.426.559.389.150. ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ...
... disulfonic acid). In the present study, we found that DIDS inhibited the proliferation of Hep3B hepatocellular carcinoma (HCC) ... diisothiocyanostilbene-2,2- ... Fatty acid oxidation (FAO) fuels many cancers. However, ... Nuclear VCP drives colorectal cancer progression by promoting fatty acid oxidation. Huang, Youwei; Wang, Fang; Lin, Xi; Li, ... and aspartic acid was used as a spacer arm to improve the vascular endothelial growth factor crosslink efficiency on the DPP ...
Disulfonic Acid 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine ... Diisothiocyanostilbene-2,2- ... 12-R-HETE use 12-Hydroxy-5.8,10,14-eicosatetraenoic Acid 12-S- ... 99mTc-Dimercaptosuccinic Acid use Technetium Tc 99m Dimercaptosuccinic Acid 99mTc-DMSA use Technetium Tc 99m Dimercaptosuccinic ... 12-S-Hydroxyeicosatetraenoic Acid use 12-Hydroxy-5.8,10,14-eicosatetraenoic Acid ...
We found that the Cl(-) channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) and DIDS applied at ... Diisothiocyanostilbene-2,2-Disulfonic Acid / pharmacology * Adenylyl Cyclases / metabolism * Animals * Anoctamins * Calcium / ...
Disulfonic Acid/pharmacology; Adenosine Triphosphate/pharmacology; Animals; Animals, Newborn; Aspartic Acid/metabolism*; ... Diisothiocyanostilbene-2,2- ... swelling causes astrocytes to release excitatory amino acids, ... benzoic acid (NPPB), dideoxyforskolin, L-644711, ATP, ITP, 3'-azido-3'-deoxythymidine, DIDS, and tamoxifen but not by ... KCl-induced D-[3H]aspartate release was inhibited by the anion channel inhibitors 5-nitro-2-(3-phenylpropylamino) ...
Disulfonic Acid / metabolism Actions. * Search in PubMed * Search in MeSH * Add to Search ... Diisothiocyanostilbene-2,2- ... doi: 10.1186/s12920-022-01399-2. BMC Med Genomics. 2022. PMID: ... 2022 Jul;57(4):432-440. doi: 10.5152/TurkArchPediatr.2022.21362. Turk Arch Pediatr. 2022. PMID: 35822476 Free PMC article. ...
... disulfonic acid (DIDS), 9-anthracene carboxylic acid and 2-(p-chlorophenoxy)propionic acid derivatives.[5,16,17] Such ... diisothiocyanostilbene-2,2- ... the activities of ClC-K1 and ClC-K2 were inhibited by 4,4- ... Bernhard K Krämer,1 Tobias Bergler,1 Benjamin Stoelcker,1 Siegfried Waldegger 2 1Klinik und Poliklinik für Innere Medizin II ... 2008;4(1):38-46. © 2008 Nature Publishing Group Cite this: Mechanisms of Disease: The Kidney-specific Chloride Channels ClCKA ...
Stilbene Disulfonic Acid DIDS Registry Number. Q1O6DSW23R. Related Numbers. 53005-05-3. CAS Type 1 Name. Benzenesulfonic acid, ... Diisothiocyanostilbene-2,2-Disulfonic Acid Preferred Term Term UI T053434. Date10/21/1992. LexicalTag NON. ThesaurusID NLM ( ... Stilbene Disulfonic Acid Term UI T053433. Date10/21/1992. LexicalTag NON. ThesaurusID NLM (1994). ... Disulfonic Acid Preferred Concept UI. M0027010. Registry Number. Q1O6DSW23R. Related Numbers. 53005-05-3. Scope Note. An ...
Stilbene Disulfonic Acid DIDS Registry Number. Q1O6DSW23R. Related Numbers. 53005-05-3. CAS Type 1 Name. Benzenesulfonic acid, ... Diisothiocyanostilbene-2,2-Disulfonic Acid Preferred Term Term UI T053434. Date10/21/1992. LexicalTag NON. ThesaurusID NLM ( ... Stilbene Disulfonic Acid Term UI T053433. Date10/21/1992. LexicalTag NON. ThesaurusID NLM (1994). ... Disulfonic Acid Preferred Concept UI. M0027010. Registry Number. Q1O6DSW23R. Related Numbers. 53005-05-3. Scope Note. An ...
Disulfonic Acid N0000167056 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine N0000167084 4-(3-Butoxy-4- ... Diisothiocyanostilbene-2,2- ... boric acid N0000008066 Boric Acids N0000166857 Borinic Acids ... Neutral N0000006806 Amino Acids N0000011372 Amino Acids, Acidic N0000011248 Amino Acids, Aromatic N0000011332 Amino Acids, ... Acyclic N0000008269 Acids, Aldehydic N0000007628 Acids, Carbocyclic N0000007629 Acids, Heterocyclic N0000007630 Acids, ...
... disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well ... Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or ... Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. ... diisothiocyanostilbene-2,2-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects ...
... disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well ... Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or ... Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. ... diisothiocyanostilbene-2,2-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects ...
Disulfonic Acid MH OLD = DMPP [P] MH NEW = Dimethylphenylpiperazinium Iodide MH OLD = DOM [N] MH NEW = 2,5-Dimethoxy-4- ... Diisothiocyanostilbene-2,2- ... disulfonic Acid MH OLD = Sporozoea # [N] MH NEW = Apicomplexa ... Etidronic Acid MH OLD = Freons [P] MH NEW = Chlorofluorocarbons, Methane MH OLD = Gastrospirillum hominis [P] MH NEW = ... Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester MH OLD = Esophageal Diverticulum [P] MH NEW = Diverticulum, ...
... disulfonic acid (DIDS), but was not inhibited by organic cation transporter (OCT)/organic cation/carnitine transporter (OCTN) ... diisothiocyanostilbene-2,2- ... oxidized form of the amino acid cysteine) and enzymes with ... Comparative microarray analysis revealed the upregulation of genes related to fatty acid oxidation (FAO) pathways in AT2 cells ... 4. Abdominal pain accompanied by elevated serum inflammatory markers and biliary enzymes for diagnosing immune checkpoint ...
Disulfonic Acid 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine ... Diisothiocyanostilbene-2,2- ... 6-Aminocaproic Acid use Aminocaproic Acid 6-Aminohexanoic Acid ... 99mTc-Dimercaptosuccinic Acid use Technetium Tc 99m Dimercaptosuccinic Acid 99mTc-DMSA use Technetium Tc 99m Dimercaptosuccinic ... 12-S-HETE use 12-Hydroxy-5.8,10,14-eicosatetraenoic Acid 12-S-Hydroxyeicosatetraenoic Acid use 12-Hydroxy-5.8,10,14- ...
Disulfonic Acid 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone 4- ... Diisothiocyanostilbene-2,2- ... Acids Acids, Acyclic Acids, Aldehydic Acids, Carbocyclic Acids ... Amino Acids Amino Acids, Acidic Amino Acids, Aromatic Amino Acids, Basic Amino Acids, Branched-Chain Amino Acids, Cyclic Amino ... Acid Ceramidase Acid Etching, Dental Acid Phosphatase Acid Rain Acid Sensing Ion Channel Blockers Acid Sensing Ion Channels ...
Disulfonic Acid/pharmacology MH - Amino Acid Sequence MH - Animals MH - Base Sequence MH - Cell Line MH - Chloride Channels/* ... Diisothiocyanostilbene-2,2-Disulfonic Acid) SB - IM EIN - Am J Physiol 1998 Oct;275(4 Pt 1 MH - 4,4-Diisothiocyanostilbene-2, ... Abscisic Acid) RN - 69-72-7 (Salicylic Acid) RN - 7647-14-5 (Sodium Chloride) SB - IM MH - Abscisic Acid/pharmacology MH - ... Lactic Acid/metabolism MH - Phosphoenolpyruvate/metabolism MH - Pyruvic Acid/metabolism MH - Succinic Acid/*metabolism EDAT- ...
... disulfonic Acid [D02.455.426.559.389.150.700.050] 4-Acetamido-4-isothiocyanatostilbene-2,2-disulfonic Acid ... Diisothiocyanostilbene-2,2-Disulfonic Acid [D02.455.426.559.389.150.700.200] 4,4-Diisothiocyanostilbene-2,2-Disulfonic Acid ... Organic compounds that contain 1,2-diphenylethylene as a functional group.. Allowable Qualifiers:. AD administration & dosage. ...
  • The sulfated form of TLC (TLCS) causes Ca 2+ signalling in pancreatic acinar cells via an inositol 1,4,5-trisphosphate (IP 3 )-dependent mobilization of sequestered intracellular Ca 2+ (49). (pancreapedia.org)
  • The increment in [3H]MI is observed at 37 degrees C but not at 4 degrees C. MI uptake is Na+ dependent in cells grown both in hyperosmolal or isotonic media. (physiology.org)
  • 2016). The effects of bile acids on pancreatic ductal cells. (pancreapedia.org)
  • Unfortunately, we do not know the concentration of bile acids that can reach the pancreatic ductal cells under pathological conditions. (pancreapedia.org)
  • It has been shown that one of the most toxic BAs to acinar cells is the secondary BA, taurolithocholic acid (TLC) that forms from LCA after re-absorption from the intestine. (pancreapedia.org)
  • We found that the Cl(-) channel blockers niflumic acid, 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) and DIDS applied at the extracellular side of the membrane caused a similar inhibition of the two currents. (nih.gov)
  • [ 12 ] In addition, the activities of ClC-K1 and ClC-K2 were inhibited by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), 9-anthracene carboxylic acid and 2-(p-chlorophenoxy)propionic acid derivatives. (medscape.com)
  • Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. (nih.gov)
  • Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. (nih.gov)
  • Organic compounds that contain 1,2-diphenylethylene as a functional group. (bvsalud.org)
  • p = 0.363), with higher grade 3-4 hematologic toxicity. (bvsalud.org)
  • PMID- 9339686 OWN - NLM STAT- MEDLINE DA - 19971114 DCOM- 19971114 LR - 20061115 PUBM- Print IS - 0028-3878 (Print) VI - 49 IP - 4 DP - 1997 Oct TI - Higher neonatal cerebral blood flow correlates with worse childhood neurologic outcome. (nih.gov)
  • Follow-up information at ages 4 to 12 years was obtained on all 26 subjects. (nih.gov)

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