4 1bb ligand. Medical search

A membrane bound member of the TNF superfamily that is expressed on activated B-LYMPHOCYTES; MACROPHAGES; and DENDRITIC CELLS. The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES.

A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)

Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.

A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.

Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.

A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.

A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.

4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. (1/160)

A20 is a B cell lymphoma that constitutively expresses the costimulatory molecule B7-2 yet grows readily as a tumor in syngeneic BALB/c mice. We have compared the tumorigenicity of A20 variants expressing either B7-1 (A20/B7-1) or B7-2 (A20/B7-2) with an A20 variant expressing B7-1 and B7-2 with 4-1BBL (A20/4-1BBL), a costimulatory member of the TNF family. Mice injected with tumors expressing the vector backbone (A20/CMV) or B7-1 developed tumors within 25 days of s.c. injection. In contrast, mice injected with A20/4-1BBL were tumor free for the 150-day follow-up period, while 25% of mice injected with A20/B7-2 developed tumors. Tumorigenicity experiments using nude mice indicated the requirement for T cells for variant rejection. Almost all mice that resisted the initial tumor challenge were resistant to further challenge with the parental tumor. Splenocytes from these mice showed high CTL lytic activity against the parental tumor, A20, as well as the syngeneic BALB/c lymphoma K46J, but showed background levels of lytic activity against the congenic SCID thymoma line ST-D2 or the allogeneic EL4 thymoma. In vitro blocking experiments with anti-B7-1 plus anti-B7-2 and/or soluble 4-1BB receptor showed B7-1, B7-2, and 4-1BBL all contributed to the CTL activity. Thus, the data show that neither B7-1 or B7-2 alone can confer full immunogenicity to the A20 lymphoma but that the addition of 4-1BBL results in a tumor that is highly immunogenic and can confer long-lasting protection against challenge with parental tumor in vivo. (+info)

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. (2/160)

After recognition of Ag/MHC and ligation of a costimulatory molecule, resting T cells will clonally expand and then delete to very low levels. Previously, it was shown that deletion can be prevented by coinjection of cytokines or proinflammatory agents such as adjuvants. Here, we demonstrate that ligation of 4-1BB blocks deletion of superantigen-activated T cells in the absence of adjuvant or additional cytokine treatment. Nearly 10 times as many staphylococcal enterotoxin A-specific T cells were detected in the spleens of mice injected 21 days previously with staphylococcal enterotoxin A and an agonist anti-4-1BB Ab compared with mice given staphylococcal enterotoxin A and a control IgG. Even though both CD4- and CD8-activated T cells expressed 4-1BB, a higher proportion of CD8 T cells were rescued compared CD4 T cells. These data suggest that although 4-1BB provides costimulation, it may also promote long-term T cell survival. (+info)

Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. (3/160)

4-1BB ligand (4-1BBL) is a member of the TNF family expressed on activated APC. 4-1BBL binds to 4-1BB (CD137) on activated CD4 and CD8 T cells and in conjunction with strong signals through the TCR provides a CD28-independent costimulatory signal leading to high level IL-2 production by primary resting T cells. Here we report the immunological characterization of mice lacking 4-1BBL and of mice lacking both 4-1BBL and CD28. 4-1BBL-/- mice mount neutralizing IgM and IgG responses to vesicular stomatitis virus that are indistinguishable from those of wild-type mice. 4-1BBL-/- mice show unimpaired CTL responses to lymphocytic choriomeningitis virus (LCMV) and exhibit normal skin allograft rejection but have a weaker CTL response to influenza virus than wild-type mice. 4-1BBL-/-CD28-/- mice retain the CTL response to LCMV, respond poorly to influenza virus, and exhibit a delay in skin allograft rejection. In agreement with these in vivo results, allogeneic CTL responses of CD28-/- but not CD28+/+ T cells to 4-1BBL-expressing APC are substantially inhibited by soluble 4-1BB receptor as is the in vitro secondary response of CD28+ T cells to influenza virus peptides. TCR-transgenic CD28-/- LCMV glycoprotein-specific T cells are insensitive to the presence of 4-1BBL when a wild-type peptide is used, but the response to a weak agonist peptide is greatly augmented by the presence of 4-1BBL. These results further substantiate the idea that different immune responses vary in their dependence on costimulation and suggest a role for 4-1BBL in augmenting suboptimal CTL responses in vivo. (+info)

4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. (4/160)

4-1BB (CD137) is a costimulatory molecule expressed on activated T cells and interacts with 4-1BB ligand (4-1BBL) on APCs. To investigate the role of 4-1BB costimulation for the development of primary immune responses, 4-1BBL-deficient (4-1BBL-/-) mice were infected with lymphocytic choriomeningitis virus (LCMV). 4-1BBL-/- mice were able to generate CTL and eliminate acute LCMV infection with normal kinetics, but CD8 T cell expansion was 2- to 3-fold lower than in wild-type (+/+) mice. In the same mice, virus-specific CD4 Th and B cell responses were minimally affected, indicating that 4-1BB costimulation preferentially affects CD8 T cell responses. This result contrasts with our earlier work with CD40L-deficient (CD40L-/-) mice, in which the CD8 T cell response was unaffected and the CD4 T cell response was markedly impaired. When both 4-1BBL- and B7-dependent signals were absent, CD8 T cell expansion was further reduced, resulting in lower CTL activity and impairing their ability to clear LCMV. Altogether, these results indicate that T cells have distinct costimulatory requirements: optimal CD8 responses require 4-1BBL-dependent interactions, whereas CD4 responses are minimally affected by 4-1BB costimulation, but require CD40-CD40L and B7-dependent interactions. (+info)

Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. (5/160)

Infection of inbred mouse strains with Leishmania major is a well characterized model for analysis of T helper (Th)1 and Th2 cell development in vivo. In this study, to address the role of costimulatory molecules CD27, CD30, 4-1BB, and OX40, which belong to the tumor necrosis factor receptor superfamily, in the development of Th1 and Th2 cells in vivo, we administered monoclonal antibody (mAb) against their ligands, CD70, CD30 ligand (L), 4-1BBL, and OX40L, to mice infected with L. major. Whereas anti-CD70, anti-CD30L, and anti-4-1BBL mAb exhibited no effect in either susceptible BALB/c or resistant C57BL/6 mice, the administration of anti-OX40L mAb abrogated progressive disease in BALB/c mice. Flow cytometric analysis indicated that OX40 was expressed on CD4(+) T cells and OX40L was expressed on CD11c(+) dendritic cells in the popliteal lymph nodes of L. major-infected BALB/c mice. In vitro stimulation of these CD4(+) T cells showed that anti-OX40L mAb treatment resulted in substantially reduced production of Th2 cytokines. Moreover, this change in cytokine levels was associated with reduced levels of anti-L. major immunoglobulin (Ig)G1 and serum IgE. These results indicate that anti-OX40L mAb abrogated progressive leishmaniasis in BALB/c mice by suppressing the development of Th2 responses, substantiating a critical role of OX40-OX40L interaction in Th2 development in vivo. (+info)

Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long- term remission of liver metastases in a mouse model. (6/160)

BACKGROUND: The success of immunomodulatory cancer therapy is frequently hampered by the transient nature of the antitumor immune response. We have shown previously in a mouse model that interleukin 12 (IL-12) generates a strong natural killer (NK) cell-mediated antitumor response and reduces liver metastases induced by a colon carcinoma cell line. However, only a small percentage of the treated animals developed the cytotoxic T-lymphocytic response required for a long-term systemic antitumor immunity. 4-1BB is a co-stimulatory molecule expressed on the surface of activated T cells. Interaction of 4-1BB with its natural ligand (4-1BBL) has been shown to amplify T-cell (especially CD8+)-mediated immunity. In this study, we investigated the effects of adenovirus-mediated gene therapy delivering both IL-12 and 4-1BBL genes on mice with hepatic metastases induced by colon cancer cells. METHODS: Syngeneic BALB/c mice received intrahepatic injection of poorly immunogenic MCA26 colon cancer cells. Various combinations of replication-defective adenoviruses expressing IL-12 and 4-1BBL genes were injected into the established liver tumors. Changes in tumor size and animal survival were then monitored. All statistical tests were two-sided. RESULTS: The long-term survival rate of mice treated with the combination of IL-12 and 4-1BBL was significantly improved over that of animals in the control group (P =.0001). In vivo depletion of NK cells or CD8+ T cells completely abolished the long-term survival advantage of the IL-12 plus 4-1BBL-treated animals (P<.002). Moreover, the systemic immunity induced by this combination treatment protected these animals against a subcutaneous challenge with parental MCA26 cells. CONCLUSION: Adenovirus-mediated transfer of IL-12 and 4-1BBL genes directly into liver tumors resulted in tumor regression that required both NK and CD8+ T cells and generated a potent, long-lasting antitumor immunity. (+info)

4-1BB: still in the midst of darkness. (7/160)

4-1BB is a member of the tumor necrosis factor receptor superfamily. The receptor functions mainly as a costimulatory molecule in T lymphocytes. In addition, several lines of evidence have shown that interactions between 4-1BB and its ligand are involved in the antigen presentation process and the generation of cytotoxic T cells. Recent studies, however, have demonstrated that 4-1BB plays more diverse roles: Signals through 4-1BB are important for long-term survival of CD8+ T cells and the induction of helper T cell anergy. Clinically, there is great interest in 4-1BB, because T-cell activation induced by anti-4-1BB monoclonal antibodies is highly efficient in the eradication of established tumor cells in mice. Now, since mice deficient in 4-1BB or the 4-1BB ligand are available, subtle roles played by 4-1BB may be revealed in the near future. (+info)

Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation. (8/160)

In an orthotopic model of metastatic colon carcinoma established in the liver of mice, we have previously shown that the natural killer (NK) cells were the major effectors after intratumoral delivery of a recombinant adenovirus expressing the murine IL-12 gene. However, tumor cure and long-term survival were achieved only in a minority of animals. In the present study, we generated an effective antitumoral CD8(+ ) T-cell response by the combination of IL-12 gene therapy and systemic delivery of an agonistic monoclonal antibody against 4-1BB, a costimulatory molecule expressed on activated T cells. In the IL-12 plus anti-4-1BB combination treatment, the effective dose of IL-12 could even be reduced even up to 18-fold and still achieved a better efficacy than the maximal dose of either treatment alone. We further demonstrate that the innate and the adaptive antitumoral immune responses were synergistic, as animals bearing hepatic as well as multiple pulmonary metastases were quantitatively cured of their diseases after IL-12 gene therapy + anti-4-1BB combination treatment. Both NK and CD8(+) T cells were necessary in maintaining the long-term antitumor immunity, as depletion of either cell type in the cured animals abolished their abilities to reject tumor cells implanted at distal sites. These results indicate that synergism between innate and adaptive immune responses may be effectively exploited to treat patients with metastatic diseases. (+info)

"Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell ... DeBenedette, M. A.; Shahinian, A.; Mak, T. W.; Watts, T. H. (1997). "Costimulation of CD28- T lymphocytes by 4-1BB ligand". ...

https://en.wikipedia.org/wiki/Tania_Watts

Schwarz H (March 2005). "Biological activities of reverse signal transduction through CD137 ligand". Journal of Leukocyte ... receptor and ligand and potential applications in cancer therapy". Archivum Immunologiae et Therapiae Experimentalis. 47 (5): ... 8 (4): 281-4. doi:10.1038/cmi.2010.82. PMC 4002439. PMID 21217771. Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS (January 1998). " ... Zhou Z, Kim S, Hurtado J, Lee ZH, Kim KK, Pollok KE, Kwon BS (February 1995). "Characterization of human homologue of 4-1BB and ...

https://en.wikipedia.org/wiki/CD137

Its ligand is ICOSL, expressed mainly on B cells and dendritic cells. The molecule seems to be important in T cell effector ... The ligand for GITR is mainly expressed on antigen presenting cells. Antibodies to GITR have been shown to promote an anti- ... PD-1: short for Programmed Death 1 (PD-1) receptor, has two ligands, PD-L1 and PD-L2. This checkpoint is the target of Merck & ... Binding with its two ligands are CD80 and CD86, expressed on dendritic cells, prompts T cell expansion. CD28 was the target of ...

https://en.wikipedia.org/wiki/Immune_checkpoint

"Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand ...

https://en.wikipedia.org/wiki/CPC_Scientific

Binding of the B7 of APC to CTLA-4 of T-cells causes inhibition of the activity of T-cells. There are two major types of B7 ... The B7-CTLA-4 binding suppresses T cell activation. The balance between the opposing signals generated by B7-CD28 and B7-CTLA-4 ... In the TNF family of molecules, the protein 4-1BB (CD137) on the T cell may bind to 4-1BB ligand (4-1BBL) on the APC. The B7 ( ... CTLA-4-knockout mice are unable to stop immune responses, and develop a fatal massive lymphocyte proliferation. Apart from B7-1 ...

https://en.wikipedia.org/wiki/B7_(protein)

Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is ... Ligand at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description, Short ... The link with 4-1BBL is largely made up of amino acids from the dynamic loops of the CRD2 and the β sheet of CRD3 of 4-1BB, ... The 4-1BB/4-1BBL complex consists of three monomeric 4-1BBs bound to a trimeric 4-1BBL. Each 4-1BB monomer binds to two 4-1BBLs ...

https://en.wikipedia.org/wiki/TNFSF9

OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as ... Stüber E, Neurath M, Calderhead D, Fell HP, Strober W (May 1995). "Cross-linking of OX40 ligand, a member of the TNF/NGF ... February 2008). "Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in ... April 2004). "Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in ...

https://en.wikipedia.org/wiki/OX40_ligand

... is one of the most studied ligands for HAVCR2 (TIM-3) and is expressed on various tumor cells. However, it can also ... "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity". Nature Immunology. 6 (12): 1245-52. doi:10.1038/ ... "Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 ... "A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9". Biochemical and Biophysical ...

https://en.wikipedia.org/wiki/Galectin-9

This can include cytokines, such is IL-2, IL-5, IL-12 and co‐stimulatory ligands. Adding a synthetic control mechanism to ... 1BB). The intracellular signaling domain used defines the generation of a CAR T cell. First generation CARs include only a CD3- ... 1BB. The involvement of these intracellular signaling domains improve T cell proliferation, cytokine secretion, resistance to ... usually taking advantage of ligand/receptor pairs that normally bind to each other. Cytokines, innate immune receptors, TNF ...

https://en.wikipedia.org/wiki/CAR_T_cell

It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. When CD27 binds ... 10 (4): 427-36. doi:10.1038/ni.1717. PMC 4167721. PMID 19270712. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman ... 13 (11): 4-15. Sánchez MJ, Holmes A, Miles C, Dzierzak E (December 1996). "Characterization of the first definitive ... Sturgill ER (November 2017). "TNFR agonists: a review of current biologics targeting OX40, 4-1BB, CD27, and GITR". American ...

https://en.wikipedia.org/wiki/CD27

... its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of ... which as a TLR9 ligand activates expression of OX40 so that it can be affected. CD134 has been shown to interact with TRAF5 and ... CTLA-4 is down-regulated following OX40 engagement in vivo and the OX40-specific TRAF3 DN defect was partially overcome by CTLA ... TRAF3 may be linked to OX40-mediated memory T cell expansion and survival, and point to the down-regulation of CTLA-4 as a ...

https://en.wikipedia.org/wiki/CD134

The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. ... 28 (4): 169-75. doi:10.1016/j.it.2007.02.005. PMID 17336158. Browning JL, Ngam-ek A, Lawton P, et al. (1993). "Lymphotoxin beta ... 271 (25): 14661-4. doi:10.1074/jbc.271.25.14661. PMID 8663299. Matsumoto M, Hsieh TY, Zhu N, et al. (1997). "Hepatitis C virus ... 1998). "TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues". Am. J. Pathol. ...

https://en.wikipedia.org/wiki/Lymphotoxin_beta_receptor

... due to ligand-defective apo B; 144010; APOB Hypercholesterolemia, familial; 143890; LDLR Hypercholesterolemia, familial, 3; ... 1BB; 612877; DSG2 Cardiomyopathy, dilated, 1CC; 613122; NEXN Cardiomyopathy, dilated, 1D; 601494; TNNT2 Cardiomyopathy, dilated ... 4; 604352; GPR98 COPD, rate of decline of lung function in; 606963; MMP1 Coproporphyria; 121300; CPOX Cornea plana congenita, ... KRAS Noonan syndrome 4; 610733; SOS1 Noonan syndrome 5; 611553; RAF1 Noonan syndrome 6; 613224; NRAS Noonan-like syndrome with ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

Binding of a ligand to a monomeric receptor tyrosine kinase stabilizes interactions between two monomers to form a dimer, after ... 147 (4): 934-946. doi:10.1016/j.cell.2011.08.052. PMC 3220604. PMID 22078888. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, ... Over the last 4 years, dozens of studies have been published, each identifying thousands of sites, many of which were ... 37 (Pt 4): 627-641. doi:10.1042/BST0370627. ISSN 1470-8752. PMID 19614568. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM ...

https://en.wikipedia.org/wiki/Protein_phosphorylation

Although pathogen-derived TLR ligands are well characterized, elucidation of TLR ligands derived from self-tissues continues. ... OX40 ligands, and CD28 ligands, all of which can enhance T-cell expansion after activation. Anti-4-1BB antibodies have been ... A total of 13 TLRs have been identified in humans, each binding 1 or more specific TLR ligands. [15] TLRs can be activated by ... Among these are blocking antibodies to CTLA4, anti-CD25 to deplete regulatory T cells, and blockers of PD-1 and its ligand, PD- ...

https://www.medscape.com/answers/991158-188387/how-do-mdscs-affect-immunotherapeutic-targeting-in-pediatric-oncology

https://www.medscape.com/answers/991158-188384/what-are-the-limitations-of-innate-immune-system-activation-in-immunotherapeutic-targeting-in-pediatric-oncology

https://www.medscape.com/answers/991158-188392/what-are-the-limitations-of-adaptive-immune-system-activation-in-immunotherapeutic-targeting-in-pediatric-oncology

https://www.medscape.com/answers/991158-188386/how-do-the-different-types-of-natural-killer-t-cells-affect-immunotherapeutic-targeting-in-pediatric-oncology

Volume 16, Number 4-April 2010 Dispatch. Limited Susceptibility of Chickens, Turkeys, and Mice to Pandemic (H1N1) 2009 Virus On ... 2010;16(4):703-705. doi:10.3201/eid1604.091491.. APA. Kalthoff, D., Grund, C., Harder, T. C., Lange, E., Vahlenkamp, T. W., ... Volume 16, Number 4-April 2010. Article Views: 271. Data is collected weekly and does not include downloads and attachments. ... Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary ...

https://wwwnc-origin.cdc.gov/eid/article/16/4/09-1491_article

https://wwwnc.cdc.gov/eid/article/16/4/09-1491_article

https://www.medscape.com/answers/991158-188382/what-is-the-role-of-mtp-pe-in-immunotherapeutic-targeting-in-pediatric-oncology

https://www.medscape.com/answers/991158-188385/how-do-macrophages-affect-immunotherapeutic-targeting-in-pediatric-oncology

https://www.medscape.com/answers/991158-188388/how-does-activation-of-the-adaptive-immune-system-affect-immunotherapeutic-targeting-in-pediatric-oncology

http://emedicine.medscape.com/article/991158-overview

https://www.medscape.com/answers/991158-188393/what-is-the-role-of-cytokine-and-growth-factor-therapy-in-immunotherapeutic-targeting-in-pediatric-oncology

Jacobson: Yes, it was a slightly smaller series than the first group.[4] What was really remarkable was that when each group ... Dr Saar Gill and the rest of the University of Pennsylvania group have taken that 4-1BB construct and added on the use of ... The other thing I'll say about the persistence that you noted with the 4-11B ligand armored CAR is that there are some ... This is a CD 19-28z CAR that has a second transgene that encodes for 4-1BB ligand. It actually costimulates the T cell both in ...

https://www.medscape.com/viewarticle/907685

https://www.medscape.com/answers/991158-188378/what-is-the-pathophysiology-of-immunotherapeutic-targeting-of-pediatric-cancers

https://www.medscape.com/answers/991158-188377/what-is-immunotherapeutic-targeting-of-cancers-in-pediatric-oncology

https://www.medscape.com/answers/991158-188394/what-is-the-role-of-monoclonal-antibodies-in-immunotherapeutic-targeting-in-pediatric-oncology

4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL ... 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL ... 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. ... The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant Human 4-1BBL is a ...

https://www.peprotech.com/en/recombinant-human-4-1bb-ligand

A novel adenovirus expressing human 4-1BB ligand enhances antitumor immunity. Hiroshi Yoshida, Yu Katayose, Michiaki Unno, ... Dive into the research topics of A novel adenovirus expressing human 4-1BB ligand enhances antitumor immunity. Together they ...

https://tohoku.pure.elsevier.com/en/publications/a-novel-adenovirus-expressing-human-4-1bb-ligand-enhances-antitum/fingerprints/?sortBy=alphabetically

Jacobson: Yes, it was a slightly smaller series than the first group.[4] What was really remarkable was that when each group ... Dr Saar Gill and the rest of the University of Pennsylvania group have taken that 4-1BB construct and added on the use of ... The other thing Ill say about the persistence that you noted with the 4-11B ligand armored CAR is that there are some ... This is a CD 19-28z CAR that has a second transgene that encodes for 4-1BB ligand. It actually costimulates the T cell both in ...

https://www.medscape.com/viewarticle/907685

https://en.wikipedia.org/wiki/Tania_Watts

4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ... Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation. CD137 is a type I membrane protein and ... CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell ... CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell ...

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p,CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane ... Ligand/Receptor 4-1BB ligand Cell Type T cells Biology Area Costimulatory Molecules, Immunology Molecular Family CD Molecules ... 4-1BB, ILA, CD137, TNFRSF9 Isotype Mouse IgG1, κ Ave. Rating Submit a Review Product Citations publications PHA-stimulated (3 ... 4. Schwarz H, et al. 1996. Blood 87:2839.. Gene ID 3604 View all products for this Gene ID UniProt View information about CD137 ...

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https://wwwnc.cdc.gov/eid/article/16/4/09-1491_article

Human tumor necrosis factor-related apoptosis-inducing ligand receptor 4 (TRAIL-R4) ELISA Kit from Cusabio. Cat#: CSB-E04749h. ... Human tumor necrosis factor-related apoptosis-inducing ligand receptor 4 (TRAIL-R4) ELISA Kit , CSB-E04749h. (No reviews yet) ... Human Programmed cell death 1 ligand 2 (PDCD1LG2) ELISA kit , CSB-EL017667HU , CusabioHuman Programmed cell death 1 ligand 2 ( ... Human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2 (TRAIL-R2/DR5) ELISA Kit , CSB-E13164h Cusabio Elisa ...

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The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T ... The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This ... The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. ... transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory ...

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... are a receptor ligand pair belonging to the tumor necrosis factor (TNF) receptor/TNF superfamily1,2. 4-1BBL is a type II ... 173(4):2428-2434. 2004. 9. Madireddi S, Eun SY, Lee SW, et al. J Exp Med. 211(7):1433-1448. 2014. 10. Shrestha S, Noh JM, Kim ... 4. DeBenedette MA, Shahinian A, Mak TW, et al. J. Immunol. 158:551-559. 1997. 5. Futagawa T, Akiba H, Kodama T, et al. Int ... Pre-incubation with TKS-1 blocks 4-1BB-Ig binding to 4-1BBL/L5178Y cells, indicating TKS-1 is specific to mouse 4-1BBL and can ...

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In the present study, hu-imDCs (cultured 4 days) were conferred with ,i,ex vivo,/i, lower dose nicotine ... M. Nouri-Shirazi, C. Kahlden, P. Nishino, and E. Guinet, "Nicotine exposure alters the mRNA expression of Notch ligands in ... a-e) DCs derived from human PBMC with human GM-CSF and IL-4 were conferred with LY294002 (10 μmol/L) or Wortmannin (10 μmol/L) ... a-d) DCs derived from human PBMC with 100 ng/mL recombinant human GM-CSF and IL-4 were conferred with α-bungarotoxin (2 μg/mL) ...

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In TBP patients, the levels of sPD-1, sPD-L2, sCD28, sCD80, sCD27, sTIM-3, sLAG-3, sBTLA, s4-1BB and sIDO increased ... sCD27 and s4-1BB were upregulated in tuberculosis patients than in healthy controls. A lower sPD-L1 level was found in LTBI ... The circulating levels of sPD-1, sPD-L1, sCTLA-4, sBTLA, sGITR, sIDO, sCD28, ... GITR ligand, lymphocyte-activation gene 3 (LAG-3)- MHC, programmed cell death protein 1 (PD-1)- programmed cell death 1 ligand ...

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Source::Optimized DNA sequence encoding Mouse 4-1BB Ligand (4-1BBL) was expressed in HEK Cells. Molecular weight:: Recombinant ... Mouse 4-1BBL is a protein consisting of 220 amino acid residue subunits, due to glycosylation migrates as an approximately ...

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Other important markers and functional ligands expressed by TFH cells include CD40 ligand (CD40L), Src homology domain 2 (SH2) ... FLT3 ligand as a molecular adjuvant for naked RNA vaccines. Methods Mol. Biol. 1428, 163-175 (2016). ... FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines. Cancer Res. 71, 6132-6142 (2011). ... Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol. Ther. 18, 1357-1364 (2010). ...

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4-1BB) Antibody - CDw137 is a 39 kD transmembrane protein also known as 4-1BB. ... Ligand/Receptor 4-1BB ligand Cell Type T cells Biology Area Costimulatory Molecules, Immunology Molecular Family CD Molecules ... 4-1BB, ILA, CD137, TNFRSF9 Isotype Mouse IgG1, κ Ave. Rating Submit a Review Product Citations publications 3-day PHA- ... 4. Schwarz H, et al. 1996. Blood 87:2839.. Gene ID 3604 View all products for this Gene ID UniProt View information about CD137 ...

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4. Target. Target. Exodus-3 8. 1. 0.18. -0.81. 0.25. 0.89. ApoE2 517. Target. Target. APOE 12,771. 454. 0.18. -0.34. 0.88. 0.78 ... 4. 0.20. -0.80. 0.21. 0.90. Niemann Pick Disease. 1,234. Disease. Target. Sphingomyelinase. 3,060. 369. 0.19. -0.79. 0.30. 0.84 ... 4-1BB Receptor 20. Target. Target. 4-1BB Ligand 135. 9. 0.17. -0.72. 0.45. 0.85. ... BMP-4 1,255. Target. Target. BMP-2 3,889. 399. 0.18. -0.78. 0.32. 0.83. ...

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GITR Ligand GM-CSF GPR183 GPR19 GPR56 GPR83 Granulysin Granzyme A Granzyme K H-2 H-2Db H-2Dd H-2Dk H-2Kb H-2Kb bound to ... 3C4 (mIC2/4) 3C7 3D12 3D4 3D6.112 3E12 3E7 3F3 3F9 3G7A02 3G8 3H5 41A 429 (MVCAM.A) 42D1 43A3 47 49-H4 4A6 4A9 4B12 4B2.9 4B4-1 ... HIM3-4 HIM6 HIP1 HIP2 HIP8 HIR2 HIT2 HIT3a HIT8a HK1.4 HK5.3 HLADQ1 HLy-9.1.25 HM-CCR5 HM34 HM36 HM40-3 HM47 HM48-1 HM79-12 HM? ... DJR2-4 (7-8) DJR3 DL-101 DOR7D2A4 DREG-56 DTA-1 Duha59 Duno85 DX2 DX22 DX27 DX5 DX9 E11 E11/19 E13-161.7 E18 E8N1 Eat-2 EBVCS-5 ...

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Below are the disclosed royalties Ligand currently receives or is eligible to receive based on future drug approvals. ...

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CD30 ligand. Human. His, mFc. Unconjugated SDS-PAGE, ELISA, BLI, CD30. Human. His, Fc, Avi & His, LlamaFc. Biotin-labeled, PE- ... OX40 Ligand. Human, Mouse, Rhesus macaque. Fc, His, His & Avi, Avi & Fc, mFc. Biotin-labeled, Unconjugated SDS-PAGE, MALS, ... CD27 Ligand. Human, Mouse. His & Avi, mFc, His, His & Avi & Flag, His & Flag, Fc. Biotin-labeled, FITC-labeled, Unconjugated ... CD40 Ligand. Human, Mouse, Human / Rhesus macaque. His, Fc, His & Avi, Avi & Fc, Avi & His & Flag, His & Flag, mFc. Biotin- ...

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4-1BB Receptor 20. Target. Target. 4-1BB Ligand 135. 9. 0.17. -0.72. 0.45. 0.85. ...

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4 Inch QVGA AMOLED display driven by GaInZnO TFT. Kwon, J. Y., Son, K. S., Jung, J. S., Kim, T. S., Ryu, M. K., Park, K. B., ... Oak, M. A., Lee, J. H., Jang, H. M., Goh, J. S., Choi, H. J. & Scott, J. F., 2011 Jan 24, In: Physical review letters. 106, 4, ... Nakai, A., Kim, J., Kim, D. & Osuka, A., 2019 Apr 1, In: Chemistry - An Asian Journal. 14, 7, p. 968-971 4 p.. Research output ... Toh, R. J., Sofer, Z., Luxa, J., Sedmidubský, D. & Pumera, M., 2017, In: Chemical Communications. 53, 21, p. 3054-3057 4 p.. ...

https://yonsei.pure.elsevier.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2017&publicationYear=2019&publicationYear=2020&publicationYear=2021&author=4ea08752-d2bb-4534-8fa7-c608d00eecf5&format=&nofollow=true&ordering=title&descending=false&page=9

https://wwwnc-origin.cdc.gov/eid/article/16/4/09-1491_article

Toh, R. J., Sofer, Z., Luxa, J., Sedmidubský, D. & Pumera, M., 2017, In: Chemical Communications. 53, 21, p. 3054-3057 4 p.. ... Ko, M., Kim, D., Rücker, H. & Choi, W. Y., 2011 Dec, In: Journal of Semiconductor Technology and Science. 11, 4, p. 256-261 6 p ... 4×4 Hard Polymer Clad Fiber (HPCF) splitter for short reach PON system based on HCPF. Bae, S. C. & Oh, K., 2005, OFC/NFOEC 2005 ... Li, J. & Pumera, M., 2021 Feb 21, In: Chemical Society reviews. 50, 4, p. 2794-2838 45 p.. Research output: Contribution to ...

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Vezys, V., Yates, A., Casey, K. A., Lanier, G., Ahmed, R., Antia, R. & Masopust, D., Jun 4 2009, In: Nature. 459, 7247, p. E4. ... Vezys, V., Masopust, D., Desmarets, M., Wess, J. & Zimring, J. C., May 30 2007, In: Life Sciences. 80, 24-25, p. 2330-2333 4 p. ... Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L. & Ahmed, R., Feb 15 2006, In: Journal of Immunology. 176, 4, p. 2079-2083 ... Masopust, D. & Vezys, V., Oct 4 2012, In: Nature. 490, 7418, p. 41-43 3 p.. Research output: Contribution to journal › Short ...

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2002- Use of ligands to CD28 & 4-1bb to enhance CTL expansion ... 4. CAR-T cancer therapy after a disease relapse? 5. CAR T-cell ...

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OX40 Ligand. *PHEX Phosphate Regulating Neutral Endopeptidase. *Platelet Membrane Glycoproteins. *Sarcoglycans. *Synaptophysin ...

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Pages that link to "FMS-like tyrosine kinase 3 ligand". ← FMS-like tyrosine kinase 3 ligand ... Retrieved from "https://www.wikidoc.org/index.php/Special:WhatLinksHere/FMS-like_tyrosine_kinase_3_ligand" ...

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CD137 ligand (CD137L) is expressed by antigen presenting cells (APC), which use the CD137-CD137L system to enhance immune ... 2019-11-08 2016-01-01 CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen‐ ... CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes av A Karlsson-Parra - ligand as additional ... CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes av A Karlsson-Parra - ligand as additional ...

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Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in ... 4 replication in the salivary gland. Oderbolz J, Zangger N, Zimmerman L, Sandu I, Starruß J, Graw F, Oxenius A. 2021. bioRxiv. ... Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15. McArdel S, Dugast A, ...

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Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation. (biosave.com)
CD137 is a 39 kD transmembrane protein also known as 4-1BB. (biolegend.com)
CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. (biolegend.com)
4-1BBL (CD137L) and 4-1BB (CD137) are a receptor ligand pair belonging to the tumor necrosis factor (TNF) receptor/TNF superfamily 1,2 . (leinco.com)
Co-stimulatory receptor-ligand interactions that help amplify effector T cell responses include CD28-CD80, 4-1BB (also known as CD137)-4-1BB ligand, CD27-CD70. (biomedcentral.com)
receptorn 4-1BB (CD137) på aktiverade cytotoxiska T-celler och NK (Natural Den uppvisar egenskaper såsom målstyrd T-cells-aktivering, 4-1BB (CD137) för att främja potent, tumörriktad T-cellsaktivering. (web.app)
In addition, it is CD137 (4-1BB) is a member of the tumor necrosis factor (TNF) receptor family. (web.app)
CD137 is expressed by activated T cells, dendritic cells, NK cells, granulocytes av A Karlsson-Parra - ligand as additional intratumoral immune priming approach. (web.app)
We further compared the phenotype and function of CD137 + and CD137 CD137 (4-1BB) has been identified as a co-stimulatory marker, which is induced upon the specific interaction of T cells with their target cell. (web.app)
2014-01-01 CD137, also known as 4-1BB, is a member of the TNFR super family. (web.app)
CD137 (4-1BB) is a member of the tumor necrosis factor family. (web.app)
En tredje Co-domän ingår för att förbättra T-cells funktion, engrafktion, Chimeric receptors containing CD137 signal transduction domains Fältet av chimära antigen receptorn (bil) T-cellterapi går snabbt framåt med Denna analys kan kopplas till profilering T cellaktivering, utmattning och minne fenotyper. (web.app)
OverviewProduct Name:Mouse 4-1BBR Recombinant ProteinProduct Code:RPPB5744Size:5µgSpecies:MouseTarget:4-1BBRSynonyms:Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, T-cell antigen 4-1BB, CD137.Source:Sf9 Insect. (assaygenie.com)
MB‐101 incorporates a second‐generation hinge-optimized CAR containing mutations in the IgG4 linker/hinge domain to reduce off‐target Fc interactions, the 4-1BB (CD137) co‐stimulatory signaling domain for improved persistence of CAR T cells, and the extracellular domain of CD19 as a selection/safety marker. (genengnews.com)

This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. (abnova.com)
The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. (abnova.com)

4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. (peprotech.com)
4-1BBL-4-1BB interaction provides a co-stimulatory signal to T cells, resulting in increased proliferation and cytokine production 5 . (leinco.com)

The monoclonal antibody was identified by its strong reactivity with 4-1BBL-transfected L5178Y cells, cloned by limiting diffusion, purified from ascites, and found to bind to 4-1BBL/NRK and 4-1BBL/P815 cells 5 . (leinco.com)
The immunogen used to create this antibody is reported as mouse CTLA-4-human IgG1 fusion protein. (bioxcell.com)
The immunogen used to create this antibody is reported as mouse 4-1BBL transfected NRK cells. (bioxcell.com)
The immunotherapeutic effect of tucidinostat combined with anti-programmed cell death ligand 1 antibody (aPD-L1) was demonstrated. (biomedcentral.com)
Monoclonal antibody treatment, chimeric antigen receptor (CAR)-T cell therapy, and immune checkpoint inhibitors are the key immunotherapies that are being used against many cancers [ 3 , 4 ]. (springer.com)
4. The lyophilized pharmaceutical formulation of any one of Claims 1 to 3, wherein the antibody is h409A11. (gc.ca)
Provided herein are dosing regimens of an anti-immunoglobulin-like transcript 4 (anti-ILT4) antibody for treating cancer. (sumobrain.com)
4. The method of claim 1 or 2, wherein the patient is administered 30 mg of the anti-ILT4 antibody. (sumobrain.com)
No. B71-H82F2 ) to 293 overexpressing CTLA-4 was inhibited by increasing concentration of neutralizing Anti-Human CTLA-4 antibody. (acrobiosystems.com.cn)

The classic immune checkpoint consists of co-inhibitory receptors (CTLA-4, PD-1, TIGIT, LAG-3), which inhibit T-cell function and co-stimulatory receptors (GITR, 4-1BB, OX40, CD40) which stimulate T cell activation. (acrobiosystems.com)
Various CAR variants have been developed by replacing the signal domains of TCRζ or CD28 with molecules with similar functions, such as FcRγ, 4-1BB and OX40 (Eshhar et al. (justia.com)
Receptor for OX40 ligand, co-stimulatory signal for T cell proliferation and survival. (biolegend.com)

Human tumor necrosis factor-related apoptosis-inducing ligand receptor 4 (TRAIL-R4) ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
CusabioHuman tumor necrosis factor-related apoptosis-inducing ligand receptor 3, TRAIL-R3. (joplink.net)
CusabioHuman soluble tumor necrosis factor-related apoptosis inducing ligand, sTRAIL ELISA KIT. (joplink.net)
CusabioMouse soluble tumor necrosis factor-related apoptosis inducing ligand, sTRAIL ELISA KIT. (joplink.net)
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (abnova.com)
OverviewProduct Name:Mouse TNFSF14 Recombinant ProteinProduct Code:RPPB1036Size:20µgSpecies:MouseTarget:TNFSF14Synonyms:Tumor necrosis factor ligand superfamily member 14, CD258, Tnfsf14, Light.Source:Escherichia ColiPropertiesPhysical. (assaygenie.com)
OverviewProduct Name:Mouse TNFA Recombinant ProteinProduct Code:RPPB0993Size:10µgSpecies:MouseTarget:TNFASynonyms:Tnfa, Tnfsf2, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2.Source:Sf9 Insect cellsPropertiesPhysical. (assaygenie.com)
After being cross primed by pAPC, naïve CTLs stimulate a cascade of events that results in CTL attack on tumor cells through granzymes or perforin and/or through ligands of tumor necrosis factor (TNF) superfamily [ 15 ]. (springer.com)

The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. (abnova.com)

Tumor cells frequently overexpress the ligand programmed death ligand-1 (PD-L1), thereby facilitating their escape from immune surveillance [ 3 , 4 , 5 ]. (biomedcentral.com)
1 HCC often arises from a microenvironment characterized by chronic inflammation, intrinsic immunosuppression and overexpression of immune checkpoints including the programmed cell death protein 1 (PD-1) pathway and programmed death ligand 1 (PDL-1), and the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathway. (bmj.com)

4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. (peprotech.com)
Leukemia-specific T-cell reactivity induced by leukemic dendritic cells is augmented by 4-1BB targeting. (peprotech.com)
4-1BBL is expressed by activated B cells, macrophages, and dendritic cells. (leinco.com)
4-1BBL is a type II transmembrane protein expressed by splenic B and T cells, macrophages, and dendritic cells 1-5 . (leinco.com)
4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. (bioxcell.com)

CTLA-4 is expressed on activated T and B lymphocytes. (bioxcell.com)
The purpose of this study was to gain insight into the 4-1BB pathway in activated lymphocytes, which can cause T-cell-mediated liver injury. (favrskovdesign.dk)
Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. (acrobiosystems.com)

Agonistic anti-4-1BB antibodies have been reported to induce T cell-mediated antitumor immunity. (bioxcell.com)

Members of the TNF-TNF receptor superfamily play critical roles in regulating cellular activation, differentiation, and apoptosis 6 and the 4-1BBL-4-1BB interaction is important in cellular immune responses 5 . (leinco.com)
Pre-incubation with TKS-1 blocks 4-1BB-Ig binding to 4-1BBL/L5178Y cells, indicating TKS-1 is specific to mouse 4-1BBL and can interrupt the interaction between 4-1BBL and 4-1BB 5 . (leinco.com)
Receptor-ligand interaction is required for the transduction of second signal, following the first signal conveyed by the interaction of MHC molecules on APCs and T cell receptors on effector T cells loaded with cognate antigens [ 3 ]. (biomedcentral.com)
Dr. Freeman's work led directly to the development of a successful strategy for cancer immunotherapy - blocking the PD-1-ligand interaction. (getbusinesslive.com)

TKS-1 activity is directed against 4-1BBL (CD137L). (leinco.com)

CTLA-4 is among a group of inhibitory receptors being explored as cancer treatment targets through immune checkpoint blockade. (bioxcell.com)
Many tumors evade the immune system via a mechanism that exploits the PD-1 inhibitory checkpoint, and MK-3475 is designed to selectively achieve dual ligand blockade of the PD-1 protein, thereby enabling activation of T cells and restoring the immune system's ability to recognize and target cancer cells. (drugdiscoverynews.com)

Soluble receptors, each being able to interact with its ligand, are shown to modulate the activity of the respective membrane anchored receptor. (abbiosciences.com)
Many TNF receptors interact with more than one ligand. (abbiosciences.com)
Co-receptors stabilize interactions between the TCR and its ligand, the peptide-major histocompatibility complex (pMHC), and enhance Ca 2+ signaling and T cell activation. (mdpi.com)
Immune checkpoint therapies block inhibitory co-receptors, such as cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), to increase T cell Ca 2+ signaling and promote T cell survival. (mdpi.com)
Nonetheless, NK cells express multiple immune checkpoint receptors, including natural killer group 2A (NKG2A), CTLA-4, PD-1, T cell immunoglobulin mucin 3 (TIM-3), and T cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibition motif (ITIM) domains (TIGIT), which have been explored as promising therapeutic targets to enhance the specificity and activity of NK cells against a broad range of cancers. (bmbreports.org)
Latrunculin A was isolated in the Red Ocean sponge (known previously asFor immunocytochemistry not really regarding NMDA receptors, neurons had been set at 20C23 d in lifestyle in P110δ-IN-1 (ME-401) warm 4% paraformaldehyde and 4% sucrose in PBS for 15 min and had been permeabilized with 0.25% Triton X-100 for 5 min. (forgetmenotinitiative.org)
secondly, co-stimulatory/ co-inhibitory receptors on T cells must bind B7 ligand family expressed on APCs to regulate situation of T cell. (acrobiosystems.com.cn)

Further studies showed that the treatment with nicotine increases surface molecules expression via PI3K-Akt pathway and nicotine-treated murine imDCs has antitumor effects in both Lewis lung cancer and hepatocellular carcinoma [ 4 , 5 ]. (hindawi.com)
The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. (bioxcell.com)
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The relationship between the 4-1BB pathway and key genes in liver cells was studied by using the Genecard database and the bioinformatics tools of DAVID, Genomatix, and Ingenuity Pathway Analysis (IPA). (favrskovdesign.dk)
Many solid tumors have exploited this pathway by expressing PD-L1, PD-1's major ligand, in effort to turn off T-cell activity and escape immune recognition. (sarcomahelp.org)

CTLA-4 is structurally similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to the B7 family members B7-1 (CD80) and B7-2 (CD86). (bioxcell.com)

In 2002, immunobiologist Leiping Chen, M.D., Ph.D., then at the Mayo Clinic in Rochester, Minn., reported that a variety of human tumors express PD-L1 (or B7-H1), the main ligand for PD-1, and that it increases apoptosis of tumor-specifi c T cells in vitro. (kengarber.com)
T-cell receptor-induced apoptosis regulates immune responses and can result from interactions between Fas (Apo1/CD95) and Fas ligand (FasL). (embl.de)

Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can be readily blocked by antibodies. (bioxcell.com)
Glioma-associated microglia and myeloid cells (GAMs) constitute about one-third of GBM tumor mass and promote tumor growth through bidirectional interactions with glioma cells [ 4 - 6 ]. (thno.org)

In the present study, hu-imDCs (cultured 4 days) were conferred with ex vivo lower dose nicotine stimulation and the effect of nicotine on surface molecules expression, the ability of cross-presentation, DCs-mediated PBMC priming, and activated signaling pathways were determined. (hindawi.com)
The technique for producing cyclic nodal arrays from linear ones can be generalised and is the basis for descriptions of the bonding in molecules with four or more ligands around the central atom, in the same way as we have seen above for EH3. (arvidssonconsulting.se)
Foreign antigen fragments presented by specific major histocompatibility complex (in humans, called human leukocyte antigens or HLAs) molecules are essentially ligands for the TCR. (cellculturedish.com)

By adding 4-1BB cytoplasmic domains to the CD28-CD3ζ signaling moieties, we found increased transgene persistence in 4D5 CAR-transduced PBLs. (mskcc.org)

BAFF binds to three TNF receptor superfamily members: B‑cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). (bio-techne.com)

With an optimized dose, tucidinostat could alter TME and promote the migration and infiltration of CD8 + T cells into tumors, partially by increasing the activity of C-C motif chemokine ligand 5 (CCL5) via NF-κB signaling. (biomedcentral.com)
C-C motif chemokine receptor 4. (invivogen.com)

The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane protein domain, and a 205 amino acid extracellular domain. (peprotech.com)
Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues. (peprotech.com)
Research on the co-inhibitory receptor CTLA-4 (cytotoxic T-lymphocyte antigen 4) and PD-1 (programmed cell death protein 1) showed significantly improved survival rates of patients with metastatic solid tumors after inhibition of these receptor pathways. (acrobiosystems.com)
New immunotherapeutic targets is another high-priority topic for research, and Marta Trüb and colleagues demonstrate promising in vitro anti-tumor properties with a novel fibroblast activation protein (FAP)-targeted 4-1BB agonist (FAP-4-1BBL). (sitcancer.org)

Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- κB, c-Jun and p38 downstream pathways. (bioxcell.com)

Almost all ligands for TNFR superfamily members belong to TNF superfamily (TNFSF). (abbiosciences.com)

The production of the type 2 cytokines, IL-4 and IL-10, by CD4+ T cells was also stimulated by All You are here. (web.app)

The monoclonal antibodies 19H3 and TKS-1 bind to different sites on murine 4-1BBL, with TKS-1 binding to a site that overlaps with the receptor binding site 7 . (leinco.com)

A TKS-1-producing hybridoma was generated by immunizing a SD rat with 4-1BBL-transfected NRK cells (rat IgG2a,κ) 5 . (leinco.com)
Additionally, TKS-1 can block anti-CD3-stimulated T cell proliferation co-stimulated by 4-1BBL /P815 cells. (leinco.com)
Immune checkpoint proteins can regulate the immune response in malignancies and infectious diseases via numerous types of activating and inhibitory signals between antigen-presenting cells (APCs) and T cells [ 3 , 4 ]. (biomedcentral.com)
Optimized DNA sequence encoding Mouse 4-1BB Ligand (4-1BBL) was expressed in HEK Cells. (reprokine.com)
Their cognate ligands [specifically B7 ligands (Compact disc86 or Compact disc80), (B7RP-1), 4-1BBL and OX40L, respectively] are extremely expressed at the top of older antigen delivering cells (APCs). (viralposme.com)
MB-101 CAR T cells express a membrane‐tethered IL‐13 receptor ligand (IL‐13) incorporating a single‐point mutation that provides high affinity for IL13Rα2 and reduces binding to IL13Rα1 to minimize off-target effects. (genengnews.com)
Further studies in athymic nude and SCID mice revealed that T cell deficiency correlates with a higher frequency of both spontaneous and chemically induced cancer, indicating a role for T cells in cancer immunosurveillance [ 4 , 5 ]. (hindawi.com)
Furthermore, constructs with 4-1BB sequences demonstrated increased cytokine secretion and lytic activity in 4D5 CAR-transduced T cells. (mskcc.org)
Chimeric antigen receptor (CAR) T cell therapy is a rapidly emerging treatment modality that uses genetically engineered T cells to specifically target and kill cancer cells 1-4 . (cytosmart.com)
BAFF promotes the survival of B cells and is essential for B cell maturation (1‑4). (bio-techne.com)
The binding between PD-1 and its ligand PD-L1 suppresses T-cell activation and allows cancer cells to escape from body's immune surveillance. (acrobiosystems.com)

Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF-R selectively binds BAFF. (bio-techne.com)

Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists. (invivogen.com)

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2. (peprotech.com)

The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. (peprotech.com)
FAS and 4-1BB also express as soluble form by alternatively slicing off the transmenbrane-encoding exon. (abbiosciences.com)

Serial dilutions of Ipilimumab were added into Human CTLA-4, Fc Tag (Cat. (acrobiosystems.com.cn)

They will also separately evaluate MK-3475 with PF-05082566 (PF-2566), an investigational immuno-oncology agent that targets the human 4-1BB receptor, as a treatment against multiple cancer types. (drugdiscoverynews.com)
So B7 ligand family plays a significance role in human cancers and autoimmune diseases. (acrobiosystems.com.cn)
No. B71-H82F2 ) can bind to 293 cell overexpressing human CTLA-4. (acrobiosystems.com.cn)

Finally, do not miss an excellent review by Christopher A Chuckran et al of Neuropilin-1, which acts as a receptor 'hub' for sorting signals from diverse ligands to both promote regulatory T cell (Treg) stability in the tumor microenvironment and inhibit anti-tumor CD8+ T cell responses-the latest in the Immune Checkpoints Beyond PD-1 review series . (sitcancer.org)

4, 2020, which claims the benefit of priority to U.S. Provisional Patent Application No. 62/896,190, filed on Sep. (justia.com)
J Exp Med (2020) 217 (4): e20190549. (rupress.org)

Additional reported applications (for the relevant formats) include: immunoprecipitation 1,4 , inhibition of cytokine production 2,3 , and ELISA. (biolegend.com)

B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. (bio-techne.com)

Additionally, TKS-1 and 4-1BB bind to a similar site, making TKS-1 especially useful for blocking studies. (leinco.com)

Upon ligand binding, CTLA-4 negatively regulates cell-mediated immune responses. (bioxcell.com)

Fig. 4: Year of clinical study initiation for bsAbs. (nature.com)

Anatomy1

Organisms2

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. (1/160)

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. (2/160)

Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. (3/160)

4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. (4/160)

Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. (5/160)

Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long- term remission of liver metastases in a mouse model. (6/160)

4-1BB: still in the midst of darkness. (7/160)

Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation. (8/160)

4-1BB Ligand

Antigens, CD137

Ligands

Receptors, Nerve Growth Factor

Tumor Necrosis Factors

Receptors, Tumor Necrosis Factor

Rats, Inbred BB

Antigens, CD

Antigens, CD28

Antigens, CD80

Lymphocyte Activation

Mice, Inbred C57BL

T-Lymphocytes

Tumor Necrosis Factor-alpha

CD40 Ligand

4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. (1/160)

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. (2/160)

Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. (3/160)

4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. (4/160)

Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. (5/160)

Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long- term remission of liver metastases in a mouse model. (6/160)

4-1BB: still in the midst of darkness. (7/160)

Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation. (8/160)

PRIME PubMed | Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

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