Inhibitor of phosphodiesterases.
Compounds based on reduced IMIDAZOLINES which contain no double bonds in the ring.
Cell surface receptors for EPOPROSTENOL. They are coupled to HETEROTRIMERIC G-PROTEINS.
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.
Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.
Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Purine bases found in body tissues and fluids and in some plants.
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Any inflammation of the skin.
A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)
A liposarcoma containing myxomatous tissue. (Dorland, 27th ed)
A component of the PUBLIC HEALTH SERVICE that provides leadership related to the delivery of health services and the requirements for and distribution of health resources, including manpower training.
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
A long-acting injectable antipsychotic agent used for chronic schizophrenia.
One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH ... quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 - sparteine MeSH D03.438. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 - 4-chloro-7-nitrobenzofurazan MeSH D03.383. ...
It has been suggested that interleukin-4 and -5 (IL-4 and IL-5) are instrumental in the control of allergic disease. Elevated ... levels of IL-4 messenger RNA (mRNA) have been detected in numerous foci of atopic activity, including bronchoalveolar lavage ( ... DOI: 10.1016/0162-3109(95)00053-4 Abstract It has been suggested that interleukin-4 and -5 (IL-4 and IL-5) are instrumental in ... Production of IL-4 and IL-5 by T cells appears to be associated with a high affinity cyclic AMP (cAMP) phosphodiesterase (PDE ...
N6-(4-aminobenzyl)-5′-N-methylcarboxamidoadenosine. IB-MECA. N6-(3-iodobenzyl)-5′-N-methylcarboxamidoadenosine. HEPES. 4-(2- ... Figure 4 Time course of agonist-induced AC sensitization. A, Transfected CHO cells were treated with 10 μm NECA at 37° for the ... 3). Therefore, the ability of chronic A3AR activation to sensitize AC stimulation is not a result of Gidown-regulation and ... The cell line used for these experiments bound the A3AR agonist radioligand125I-AB-MECA with high affinity (Kd = 1.24 ± 0.41 nm ...
2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH ... quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 - sparteine MeSH D03.438. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 - 4-chloro-7-nitrobenzofurazan MeSH D03.383. ...
d-Pen2,d-Pen5]-enkephalin. ICI-174864. N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH. TIPP. H-Tyr-Tic-Phe-Phe-OH. DOR. δ-opioid receptor. ... 4-[(αR)-α-((2S,5R)-4-ally1-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide. BW373U86. (±)-4-((α-R*)-α-((2S*,5 ... 4; Table 2). Importantly, the EC50 for G-protein activation by TIPP in this assay was similar to its affinity (Ki) for δ-opioid ... guanosine 5′-O-(3-[35S]thio)triphosphate. KRHB. Krebs-Ringer-HEPES buffer. GppNHp. 5′-guanylylimidodiphosphate. SNC80. (+)- ...
Biphasic actions of prostaglandin E(2) on the renal afferent arteriole : role of EP(3) and EP(4) receptors. Tang, L., ... Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus. ... Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate- ... Lipopolysaccharide-induced acute renal failure in conscious rats: effects of specific phosphodiesterase type 3 and 4 inhibition ...
2. The P20 responses to S1 and S2 for E1 and E5 are displayed for each of the habituation and stress days. Both genotypes are ... 4. For the N40 component of the habituation trials, S1 during E1 on the stress day reduced to the level of S2. There was no ... 3. For the P20 component of habituation trials, only the NR1neo(−/−) mice showed a reduction in amplitude during E1 on the ... 3). However, there were no significant three-way interactions among other sets of variables (Table 1). The NR1neo(−/−) mice ...
Habre, W., Peták, F., Sly, P. D., Hantos, Z. & Morel, D. R., Jan 1 2001, In : Anesthesiology. 94, 2, p. 348-353 6 p.. Research ... Tulić, M. K., Wale, J. L., Peták, F. & Sly, P. D., Jun 3 1999, In : Thorax. 54, 6, p. 531-537 7 p.. Research output: ... Adamicza, Á., Peták, F., Asztalos, T. & Hantos, Z., May 29 1999, In : European Respiratory Journal. 13, 4, p. 767-774 8 p.. ... Suki, B., Petak, F., Adamicza, A., Hantos, Z. & Lutchen, K. R., Jan 1 1995, In : Journal of Applied Physiology. 79, 3, p. 861- ...
2-Polycyclic propynyl adenosine analogs having A2A agonist activity FR2884419A1 (en) * 2005-04-19. 2006-10-20. Galderma Sa. ... 2-Polycyclic propynyl adenosine analogs having A2A agonist activity US20090042901A1 (en) * 2005-02-02. 2009-02-12. Kowa Co., ... Substituted 4--piperidine-1-carboxylic acid esters as a2ar agonists US20110129546A1 (en) * 2008-06-20. 2011-06-02. Ignacio ... Substituted 4--piperidine-1-carboxylic acid esters as a2ar agonists US20110129546A1 (en) * 2008-06-20. 2011-06-02. Ignacio ...
2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)- Previous Indexing:. Benzyl Compounds (1972-1974). Ethers (1974). ... We invite you to complete a survey that will take no more than 3 minutes.. Go to survey ... Bis(4 Methyl 1 Homopiperazinylthiocarbonyl)disulfide [D03.383.129.308.090] Bis(4 Methyl 1 Homopiperazinylthiocarbonyl)disulfide ...
Y1 - 2010/2/10. N2 - The aim of the present study was to investigate the mode of action of luteolin on phisphodiesterase (PDE) ... 於: European Journal of Pharmacology, 卷 627, 編號 1-3, 10.02.2010, p. 269-275.. 研究成果: 雜誌貢獻 › 文章 ... Yu MC, Chen JH, Lai CY, Han CY, Ko W-C. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3 ... The EC50 (PDE4H) values of luteolin and Ro 20-1724, a selective PDE4 inhibitor, for displacing 2 nM [3H]-rolipram binding were ...
KW - 3,5-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. KW - 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/ ... keywords = "3,5-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/ ... The suppression in cAMP accumulation caused by ethanol feeding was associated with increased activity of phosphodiesterase 4. ... The suppression in cAMP accumulation caused by ethanol feeding was associated with increased activity of phosphodiesterase 4. ...
The imidazolidinone derivative, Ro 20-1724, significantly and consistently inhibited both the elevated cAMP phosphodiesterase ... The imidazolidinone derivative, Ro 20-1724, significantly and consistently inhibited both the elevated cAMP phosphodiesterase ... The imidazolidinone derivative, Ro 20-1724, significantly and consistently inhibited both the elevated cAMP phosphodiesterase ... The imidazolidinone derivative, Ro 20-1724, significantly and consistently inhibited both the elevated cAMP phosphodiesterase ...
Overall survival and histology-specific subgroup analyses from a phase 3, randomized controlled study of trabectedin or ... Five-year outcomes from a phase 3 METRIC study in patients with BRAF V600 E/K-mutant advanced or metastatic melanoma. Eur J ... Pooled Analysis of 4 Randomized Clinical Trials. JAMA Oncol. 2018 10 01; 4(10):1382-1388. ...
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone. Ro 4-1284. 2H-Benzo(a)quinolizin-2-ol 2-Ethyl-1,3,4,6,7,11b-hexahydro-3- ... trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride. BW 284 C 51. Benzenaminium, 4,4-(3-oxo-1,5-pentanediyl)bis( ... 4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride. SQ-18506. 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4- ... Insulin-Like Growth Factor Binding Protein 4. Insulin-Like Growth Factor-Binding Protein 2. Insulin-Like Growth Factor Binding ...
This graph shows the total number of publications written about "Fluspirilene" by people in this website by year, and whether "Fluspirilene" was a major or minor topic of these publications ...
Male Wistar rats were used for occlusion of the left MCA, and were sacrificed 1, 3, 7 and 14 days after MCA occlusion. In situ ... At 30 days, TBI rats had a generalized, bilateral decrease in [3 H]prazosin binding across all brain areas read (F[l,13] = 9.23 ... On the other hand, [3 H]paraminoclonidine binding did not differ from sham lesion controls in any brain area of TBI rats. Thus ... Expression was evident in the whole hemisphere of the infarcted side, especially at 1 and 3 days after ischemia, but no ...
Bai A, Yong M, Ma AG, Ma Y, Weiss CR, Guan Q, Bernstein CN, Peng Z. Novel anti-inflammatory action of 5-aminoimidazole-4- ... The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J ... Nath N, Giri S, Prasad R, Salem ML, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator ... Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation ...
The penultimate step in the pathway of histidine biosynthesis. Oxidation of the alcohol group on the side chain gives the acid group forming histidine. Histidinol has also been used as an inhibitor of protein synthesis ...
The dunce locus of Drosophila melanogaster codes for a low Km, cAMP phosphodiesterase. The correct function of this gene is required for normal learning and memory activity in flies, because dunce mutants fail in tests of behavioral conditioning. These observations have indicated that cAMP regulation is an important aspect of the biochemistry underlying learning and memory processes in insects. To determine whether the locus is functionally conserved in mammals, we have expressed dunce gene homologs from the rat in a yeast expression system. We find that the rat homologs encode low Km, cAMP phosphodiesterases similar to that coded for by the Drosophila dunce+ gene and, more importantly, that the mammalian enzymes are inhibited by rolipram and RO 20-1724, drugs with antidepressant properties. Surprisingly, the dunce-encoded phosphodiesterase was not inhibited by rolipram or RO 20-1724. These findings suggest that the phosphodiesterases, through their regulation of cAMP levels, influence learning ...
"Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" is a descriptor in the National Library of Medicines controlled ... Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide*Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide ... This graph shows the total number of publications written about "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" by ... Below are the most recent publications written about "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" by people in ...
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone .. Ro 1724 .. Ro 20 1724 .. Ro 20-1724 .. Ro 201724 .. Inhibitor of ... Low-molecular-weight fragment of heparin, having a 4-enopyranosuronate sodium structure at the non-reducing end of the chain. ... D03.383.129.308.100 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone .. D09 Carbohydrates .. D09.698 Polysaccharides .. D09.698. ...
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2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
... supplier and exporter of 2-ACETYLFLUORENE (for synthesis) based in Mumbai, Maharashtra, India. ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... UN 1717 ACETYL CHLORIDE, 3 (8), II, Segregation Group: 1 (Acids). Declaration (transport by air) IATA-DGR. UN 1717 ACETYL ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine based in Mumbai, Maharashtra, India. ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... WGK 3 highly water endangering. Disposal. 3. Relatively unreactive organic reagents should be collected in container A. If ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... WGK 3 highly water endangering. Disposal. 26. Alkali and alkaline-earth metals should be taken up in an inert solvent and ...
... supplier and exporter of 2-Iodoacetamide at low price. ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 * ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... WGK 3 highly water endangering. Disposal. 3. Relatively unreactive organic reagents should be collected in container A. If ... This chemical is commonly used to bind covalently with the thiol group of cysteine. 2 -Iodoacetamide is an irreversible ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
... supplier and exporter of 3-Methylphenyl isothiocyanate based in Mumbai, Maharashtra, India. ... 2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... WGK 3 highly water endangering. Disposal. 3. Relatively unreactive organic reagents should be collected in container A. If ...
4-DINITROPHENYL HYDRAZINE AR based in Mumbai, Maharashtra, India. ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... WGK 2 water endangering. Disposal. 15. Heavy metal-containing solutions and solids: container E. Stir Raney nickel (also: ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *2,6-DIMETHYL HYDROQUINONE. *ACETONITRILE AR. *DIMETHYL GLYOXIME DISODIUM SALT ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
  • Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • This graph shows the total number of publications written about "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" by people in this website by year, and whether "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" was a major or minor topic of these publications. (ucdenver.edu)
  • Below are the most recent publications written about "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" by people in Profiles. (ucdenver.edu)
  • Production of IL-4 and IL-5 by T cells appears to be associated with a high affinity cyclic AMP (cAMP) phosphodiesterase (PDE). (nih.gov)
  • This study was designed to compare the effects of PDE inhibitors Ro20-1724 and theophylline on (1) the mitogenic response of peripheral blood mononuclear cells from atopic and non-atopic individuals and (2) secretion of IL-4 and IL-5 by TH(2) cells after activation with PMA and anti-CD3. (nih.gov)
  • We demonstrated previously that prolonged agonist exposure of CHO cells expressing a recombinant rat A 3 AR results in a desensitization of receptor function that is associated with the down-regulation of specific G protein subunits ( 9 ). (aspetjournals.org)
  • The purpose of this study was to examine the properties of TIPP at selected points of the signal transduction pathway (i.e., receptor binding, G-protein activation, and effector regulation) in GH 3 DORT cells (GH 3 cells expressing δ-opioid receptors) and compare them with that of an established δ-opioid agonist, [ d -Pen 2 , d -Pen 5 ]-enkephalin (DPDPE). (aspetjournals.org)
  • Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. (healthsciencessc.org)
  • European Journal of Pharmacology , 627 (1-3), 269-275. (elsevier.com)
  • doi: 10.1016/0162-3109(95)00053-4. (nih.gov)
  • This is reflected in notable pharmacological differences, in particular, a 100-1000-fold-lower affinity of the rat A 3 AR for certain xanthine compounds compared with the recombinant human and sheep receptors ( 1 , 5-7 ). (aspetjournals.org)
  • This invention relates to pyrazole compounds that inhibit or modulate the activity of cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3), to the use of the compounds in the treatment or prophylaxis of disease states or conditions mediated by cyclin dependent kinases and glycogen synthase kinase-3, and to novel compounds having cyclin dependent kinase or glycogen synthase kinase-3 inhibitory or modulating activity. (allindianpatents.com)
  • Although several studies have detailed the mechanisms underlying agonist-mediated desensitization of the rat A 3 AR, the regulation of the human A 3 AR, which displays only a 70% amino acid identity with the rat homologue, has not been addressed. (aspetjournals.org)
  • A recent report demonstrated that the rat A 3 AR mRNA is subject to an alternative splicing event within the coding sequence, resulting in the insertion of a 17-amino acid segment within the second intracellular loop ( 8 ). (aspetjournals.org)
  • These phenomena are initiated by agonist binding to A 3 AR proteins whose genes have been isolated from rat, sheep, rabbit, and humans ( 4-7 ). (aspetjournals.org)
  • The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. (healthsciencessc.org)
  • Elevated levels of IL-4 messenger RNA (mRNA) have been detected in numerous foci of atopic activity, including bronchoalveolar lavage (BAL) fluid from atopic asthmatics and skin of atopic dermatitis patients. (nih.gov)
  • Similarly, both PDE inhibitors suppressed secretion of IL-4 and IL-5 from TH(2)-like cell lines in a dose-dependent manner. (nih.gov)
  • Using a Chinese hamster ovary cell line stably expressing a recombinant human A 3 AR, we demonstrated that prolonged treatment with the AR agonist 5′- N -ethylcarboxamidoadenosine induces uncoupling of the A 3 AR from G proteins and functional desensitization. (aspetjournals.org)
  • Time course experiments revealed that the onset of sensitization was half-maximal between 2 and 3 hr but was not due to the synthesis of new proteins because cycloheximide treatment failed to inhibit sensitization. (aspetjournals.org)
  • Despite the classification of these proteins as A 3 ARs, the rat protein exhibits only a 70% identity with the other species homologues. (aspetjournals.org)
  • Male Wistar rats were fed a liquid diet containing ethanol as 35% of total calories or pair-fed a control diet that isocalorically substituted maltose dextrins for ethanol for 4 wk. (dundee.ac.uk)
  • The suppression in cAMP accumulation caused by ethanol feeding was associated with increased activity of phosphodiesterase 4. (dundee.ac.uk)
  • In conclusion, these data suggest that chronic ethanol feeding increased phosphodiesterase 4 activity in adipocytes, resulting in decreased accumulation of cAMP in response to beta-adrenergic activation and a suppression of beta-adrenergic stimulation of lipolysis. (dundee.ac.uk)
  • There is about 4% incidence of atopic dermatitis from birth to 7 years (Halpern et al. (google.com)
  • The imidazolidinone derivative, Ro 20-1724, significantly and consistently inhibited both the elevated cAMP phosphodiesterase activity and the elevated spontaneous IgE synthesis of MNL from patients with atopic dermatitis. (elsevier.com)
  • In conclusion, as Ro20-1724 and theophylline inhibit proliferation of PBMC and secretion of IL-4 and IL-5 from human TH(2) cell lines, the development of a selective cyclic nucleotide PDE IV inhibitor may provide a promising new approach for asthma prophylaxis. (nih.gov)
  • The EC50 (PDE4H) values of luteolin and Ro 20-1724, a selective PDE4 inhibitor, for displacing 2 nM [3H]-rolipram binding were 11.2 μM and 45.6 nM, respectively. (elsevier.com)
  • Bai A, Yong M, Ma AG, Ma Y, Weiss CR, Guan Q, Bernstein CN, Peng Z. Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis. (healthsciencessc.org)
  • 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. (healthsciencessc.org)
  • Psoriasis is a common chronic relapsing inflammatory skin disease which affects 1-3% of the population. (google.com)
  • The inability of the sensitization process to alter the AC activity obtained in the presence of manganese chloride suggests that prolonged A 3 AR activation increases the coupling efficiency between G s and AC catalytic units. (aspetjournals.org)
  • these include cardioprotection and neuroprotection from prolonged ischemia, bronchoconstriction, mast cell and eosinophil activation, and induction of hypotension ( 1-3 ). (aspetjournals.org)
  • In assays measuring G-protein activation, TIPP failed to stimulate guanosine 5′- O -(3-[ 35 S]thio)triphosphate ([ 35 S]GTPγS) binding in membrane preparations, which is consistent with an antagonist profile. (aspetjournals.org)
  • Monocalcium Phosphate Monocalcium phosphate is a chemical compound with the formula Ca(H2PO4)2. (tradeindia.com)
  • and in said formula (f2-0-3), R 51 and R 52 each independently represents a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms, a fluorine atom or a fluorinated lower alkyl group, m f and n f each independently represents an integer of 0 to 5 (provided that m f +n f ≧1), and q' represents an integer of 0 to 5]. (patentsencyclopedia.com)
  • 5. A negative resist composition according to claim 4, wherein said fluorine-containing resin component (F) comprises said structural unit (f1), and a structural unit (f2-1), which is represented by said general formula (f2-0), in which at least one of said R 1 to R 4 is an alkali-soluble group represented by said general formula (f2-0-1). (patentsencyclopedia.com)
  • According to the Lineweaver-Burk analysis, luteolin (3-30 μM) competitively inhibited PDE1-5 activities, with Ki values of 15.0, 6.4, 13.9, 11.1, and 9.5 μM, respectively, which did not significantly differ from each other. (elsevier.com)
  • In addition to A 3 AR desensitization, a 1.5-2.5-fold increase was noted in the adenylyl cyclase (AC) activity achieved in the presence of GTP with or without forskolin. (aspetjournals.org)
  • 2. A negative resist composition according to claim 1, wherein said alkali-soluble group is a fluorinated group. (patentsencyclopedia.com)
  • Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. (healthsciencessc.org)