4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Imidazolidines

Receptors, Epoprostenol

Mannosides

Imidazoles

Receptors, Serotonin, 5-HT1

GTP-Binding Proteins

Radioligand Assay

Binding, Competitive

Binding Sites

Guanosine 5'-O-(3-Thiotriphosphate)

Molecular Sequence Data

Receptors, N-Methyl-D-Aspartate

Schizophrenia

Endophenotypes

Evoked Potentials

Electroencephalography

Photic Stimulation

Baclofen

Dermatitis, Atopic

Psoriasis

Xanthines

Pentoxifylline

Administration, Topical

Dermatitis

Dyphylline

Dacarbazine

Leiomyosarcoma

Liposarcoma

Liposarcoma, Myxoid

United States Health Resources and Services Administration

Dioxoles

Tetrahydroisoquinolines

Fluspirilene

Penfluridol

Spiro Compounds

List of MeSH codes (D03)

Methyl3

• Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
• This graph shows the total number of publications written about "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" by people in this website by year, and whether "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" was a major or minor topic of these publications. (ucdenver.edu)
• Below are the most recent publications written about "Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide" by people in Profiles. (ucdenver.edu)

Cells5

• Production of IL-4 and IL-5 by T cells appears to be associated with a high affinity cyclic AMP (cAMP) phosphodiesterase (PDE). (nih.gov)
• This study was designed to compare the effects of PDE inhibitors Ro20-1724 and theophylline on (1) the mitogenic response of peripheral blood mononuclear cells from atopic and non-atopic individuals and (2) secretion of IL-4 and IL-5 by TH(2) cells after activation with PMA and anti-CD3. (nih.gov)
• We demonstrated previously that prolonged agonist exposure of CHO cells expressing a recombinant rat A 3 AR results in a desensitization of receptor function that is associated with the down-regulation of specific G protein subunits ( 9 ). (aspetjournals.org)
• The purpose of this study was to examine the properties of TIPP at selected points of the signal transduction pathway (i.e., receptor binding, G-protein activation, and effector regulation) in GH 3 DORT cells (GH 3 cells expressing δ-opioid receptors) and compare them with that of an established δ-opioid agonist, [ d -Pen 2 , d -Pen 5 ]-enkephalin (DPDPE). (aspetjournals.org)
• Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. (healthsciencessc.org)

19961

• 1996 Mar;31(2-3):223-35. (nih.gov)

Pharmacology1

• European Journal of Pharmacology , 627 (1-3), 269-275. (elsevier.com)

10.10161

• doi: 10.1016/0162-3109(95)00053-4. (nih.gov)

Compounds2

• This is reflected in notable pharmacological differences, in particular, a 100-1000-fold-lower affinity of the rat A 3 AR for certain xanthine compounds compared with the recombinant human and sheep receptors ( 1 , 5-7 ). (aspetjournals.org)
• This invention relates to pyrazole compounds that inhibit or modulate the activity of cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3), to the use of the compounds in the treatment or prophylaxis of disease states or conditions mediated by cyclin dependent kinases and glycogen synthase kinase-3, and to novel compounds having cyclin dependent kinase or glycogen synthase kinase-3 inhibitory or modulating activity. (allindianpatents.com)

Acid2

• Although several studies have detailed the mechanisms underlying agonist-mediated desensitization of the rat A 3 AR, the regulation of the human A 3 AR, which displays only a 70% amino acid identity with the rat homologue, has not been addressed. (aspetjournals.org)
• A recent report demonstrated that the rat A 3 AR mRNA is subject to an alternative splicing event within the coding sequence, resulting in the insertion of a 17-amino acid segment within the second intracellular loop ( 8 ). (aspetjournals.org)

Humans2

• These phenomena are initiated by agonist binding to A 3 AR proteins whose genes have been isolated from rat, sheep, rabbit, and humans ( 4-7 ). (aspetjournals.org)
• The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. (healthsciencessc.org)

MRNA1

• Elevated levels of IL-4 messenger RNA (mRNA) have been detected in numerous foci of atopic activity, including bronchoalveolar lavage (BAL) fluid from atopic asthmatics and skin of atopic dermatitis patients. (nih.gov)

Inhibitors1

• Similarly, both PDE inhibitors suppressed secretion of IL-4 and IL-5 from TH(2)-like cell lines in a dose-dependent manner. (nih.gov)

Proteins3

• Using a Chinese hamster ovary cell line stably expressing a recombinant human A 3 AR, we demonstrated that prolonged treatment with the AR agonist 5′- N -ethylcarboxamidoadenosine induces uncoupling of the A 3 AR from G proteins and functional desensitization. (aspetjournals.org)
• Time course experiments revealed that the onset of sensitization was half-maximal between 2 and 3 hr but was not due to the synthesis of new proteins because cycloheximide treatment failed to inhibit sensitization. (aspetjournals.org)
• Despite the classification of these proteins as A 3 ARs, the rat protein exhibits only a 70% identity with the other species homologues. (aspetjournals.org)

Ethanol3

• Male Wistar rats were fed a liquid diet containing ethanol as 35% of total calories or pair-fed a control diet that isocalorically substituted maltose dextrins for ethanol for 4 wk. (dundee.ac.uk)
• The suppression in cAMP accumulation caused by ethanol feeding was associated with increased activity of phosphodiesterase 4. (dundee.ac.uk)
• In conclusion, these data suggest that chronic ethanol feeding increased phosphodiesterase 4 activity in adipocytes, resulting in decreased accumulation of cAMP in response to beta-adrenergic activation and a suppression of beta-adrenergic stimulation of lipolysis. (dundee.ac.uk)

Atopic2

• There is about 4% incidence of atopic dermatitis from birth to 7 years (Halpern et al. (google.com)
• The imidazolidinone derivative, Ro 20-1724, significantly and consistently inhibited both the elevated cAMP phosphodiesterase activity and the elevated spontaneous IgE synthesis of MNL from patients with atopic dermatitis. (elsevier.com)

Selective2

• In conclusion, as Ro20-1724 and theophylline inhibit proliferation of PBMC and secretion of IL-4 and IL-5 from human TH(2) cell lines, the development of a selective cyclic nucleotide PDE IV inhibitor may provide a promising new approach for asthma prophylaxis. (nih.gov)
• The EC50 (PDE4H) values of luteolin and Ro 20-1724, a selective PDE4 inhibitor, for displacing 2 nM [3H]-rolipram binding were 11.2 μM and 45.6 nM, respectively. (elsevier.com)

Acute1

• Bai A, Yong M, Ma AG, Ma Y, Weiss CR, Guan Q, Bernstein CN, Peng Z. Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis. (healthsciencessc.org)

Interaction1

• 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. (healthsciencessc.org)

Chronic1

• Psoriasis is a common chronic relapsing inflammatory skin disease which affects 1-3% of the population. (google.com)

Activation3

• The inability of the sensitization process to alter the AC activity obtained in the presence of manganese chloride suggests that prolonged A 3 AR activation increases the coupling efficiency between G s and AC catalytic units. (aspetjournals.org)
• these include cardioprotection and neuroprotection from prolonged ischemia, bronchoconstriction, mast cell and eosinophil activation, and induction of hypotension ( 1-3 ). (aspetjournals.org)
• In assays measuring G-protein activation, TIPP failed to stimulate guanosine 5′- O -(3-[ 35 S]thio)triphosphate ([ 35 S]GTPγS) binding in membrane preparations, which is consistent with an antagonist profile. (aspetjournals.org)

Formula3

• Monocalcium Phosphate Monocalcium phosphate is a chemical compound with the formula Ca(H2PO4)2. (tradeindia.com)
• and in said formula (f2-0-3), R 51 and R 52 each independently represents a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms, a fluorine atom or a fluorinated lower alkyl group, m f and n f each independently represents an integer of 0 to 5 (provided that m f +n f ≧1), and q' represents an integer of 0 to 5]. (patentsencyclopedia.com)
• 5. A negative resist composition according to claim 4, wherein said fluorine-containing resin component (F) comprises said structural unit (f1), and a structural unit (f2-1), which is represented by said general formula (f2-0), in which at least one of said R 1 to R 4 is an alkali-soluble group represented by said general formula (f2-0-1). (patentsencyclopedia.com)

Analysis1

• According to the Lineweaver-Burk analysis, luteolin (3-30 μM) competitively inhibited PDE1-5 activities, with Ki values of 15.0, 6.4, 13.9, 11.1, and 9.5 μM, respectively, which did not significantly differ from each other. (elsevier.com)

Activity1

• In addition to A 3 AR desensitization, a 1.5-2.5-fold increase was noted in the adenylyl cyclase (AC) activity achieved in the presence of GTP with or without forskolin. (aspetjournals.org)

Group1

• 2. A negative resist composition according to claim 1, wherein said alkali-soluble group is a fluorinated group. (patentsencyclopedia.com)

Cell1

• Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. (healthsciencessc.org)