4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Imidazolidines

Receptors, Epoprostenol

Mannosides

Imidazoles

List of MeSH codes (D03)

20022

• 2002 Sep;22(3):415-20. (bibsonomy.org)
• 2002 Apr;73(4):1229-35. (bibsonomy.org)

19931

• 1993 Feb;87(2):454-63. (bibsonomy.org)

19951

• 1995 Sep 1;232(2):464-72. (bibsonomy.org)

Lohse1

• Stork, Stefan Boivin, Valerie Horf, Rudiger Hein, Lutz Lohse, Martin J Angermann, Christiane E Jahns, Roland Research Support, Non-U.S. Gov't United States American heart journal Am Heart J. 2006 Oct;152(4):697-704. (bibsonomy.org)

Phosphodiesterase2

• Isoproterenol-induced enhancement of eEPSPs was promoted by pre-application of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro 20-1724), a cAMP-specific phosphodiesterase inhibitor. (nih.gov)
• The amplification of the beta-adrenergic cAMP response by these agents also occurred in the presence of isobutylmethylxanthine (10(-3) M) and Ro 20-1724 (10(-4) M), an observation suggesting that inhibition of cAMP phosphodiesterase activity is not the mechanism of action. (nih.gov)

Receptors3

• A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
• Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS. (lookformedical.com)
• Drugs that bind to and block the activation of ADRENERGIC BETA-3 RECEPTORS. (lookformedical.com)

Compounds1

• Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. (bvsalud.org)

Imidazole1

• A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity. (ucdenver.edu)

Protein1

• A selective protein kinase A inhibitor, N-[2-(p-bromocinnamylamino)ethyl]-5-soquinolinesulfonamide (H-89), inhibited the excitatory effect by isoproterenol. (nih.gov)

Activation1

• Activation of adenylate cyclase of NG108-15 neuroblastoma-glioma hybrid cells by prostaglandin E, resulted in the gradual loss of basal adenylate cyclase activity as well as enzyme activity stimulated by prostaglandin E), 2-chloroadenosine, NaF, or both pros- taglandin E, and guanyl-5'-yl imidodiphosphate. (nih.gov)

CAMP2

• The membrane permeant analog of cyclic-3',5'-AMP (cAMP), N6,2'-O-dibutyryl-AMP (db-cAMP), mimicked the facilitatory effect of isoproterenol. (nih.gov)
• The cAMP response following cholera toxin pretreatment (60-120 min) was rapidly and markedly enhanced by alpha 1-adrenergic agonists (cirazoline greater than PE greater than methoxamine), by phorbol esters (PMA greater than 4 beta-phorbol 12,13,-dibutyrate much greater than 4 alpha-phorbol 12,13-didecanoate), and by synthetic diacylglycerols (1,2-dioctanoylglycerol greater than 1-oleoyl 2-acetylglycerol much greater than diolein). (nih.gov)

Cells3

• Exposure of NG108-15 cells to 8-Br cyclic AMP also resulted in the loss of basal, prostaglandin Ej-stimulated, and 2-chlo- roadenosine-stimulated adenylate cyclase activities. (nih.gov)
• In contrast, exposure of NG108-15 cells to 2-chloroadenosine resulted in the rapid loss of response to 2-chloroadenosine with a half- life of 1.8 hr, but prostaglandin E,-stimulated and basal enzyme activities decreased only slightly. (nih.gov)
• The cells were centrifuged for 4 min at 1000 x g, and the cell pellets were frozen in Dry Ice and stored over liquid nitrogen. (nih.gov)