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FAQReceptors, Serotonin, 5-HT1: A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to GI-GO G-PROTEINS resulting in decreased intracellular CYCLIC AMP levels.GTP-Binding Proteins: Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.Radioligand Assay: Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Guanosine 5'-O-(3-Thiotriphosphate): Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Receptors, G-Protein-Coupled: The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. They share a common structure and signal through HETEROTRIMERIC G-PROTEINS.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Dermatitis, Atopic: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Xanthines: Purine bases found in body tissues and fluids and in some plants.Pentoxifylline: A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Dermatitis: Any inflammation of the skin.Dyphylline: A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis.Dermatologic Agents: Drugs used to treat or prevent skin disorders or for the routine care of skin.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Xanthine Oxidase: An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria.Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.Endophenotypes: Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.Evoked Potentials: Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Photic Stimulation: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.Baclofen: A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Alcohol Deterrents: Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.Mice, Inbred C57BLSpectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.Environmental Pollutants: Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.Epoxy Compounds: Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.Xenobiotics: Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.Butadienes: Four carbon unsaturated hydrocarbons containing two double bonds.Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)Volatilization: A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.Organic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.Lymphoma, Large-Cell, Immunoblastic: Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.Therapies, Investigational: Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.Lymphoma, Mantle-Cell: A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.Pectinidae: A large family of mollusks in the class BIVALVIA, known commonly as scallops. They possess flat, almost circular shells and are found in all seas from shallow water to great depths.Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.Cyclin-Dependent Kinases: Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.Lymphoma, B-Cell: A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.Cyclin A: A cyclin subtype that has specificity for CDC2 PROTEIN KINASE and CYCLIN-DEPENDENT KINASE 2. It plays a role in progression of the CELL CYCLE through G1/S and G2/M phase transitions.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Rats, Inbred F344Apolipoprotein B-100: A 513-kDa protein synthesized in the LIVER. It serves as the major structural protein of low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). It is the ligand for the LDL receptor (RECEPTORS, LDL) that promotes cellular binding and internalization of LDL particles.F Factor: A plasmid whose presence in the cell, either extrachromosomal or integrated into the BACTERIAL CHROMOSOME, determines the "sex" of the bacterium, host chromosome mobilization, transfer via conjugation (CONJUGATION, GENETIC) of genetic material, and the formation of SEX PILI.F2-Isoprostanes: Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Apolipoprotein B-48: A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.
List of MeSH codes (D03)
2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 --- sparteine MeSH D03.438. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 --- 4-chloro-7-nitrobenzofurazan MeSH D03.383. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin ...
Plus it
N6-(4-aminobenzyl)-5′-N-methylcarboxamidoadenosine. IB-MECA. N6-(3-iodobenzyl)-5′-N-methylcarboxamidoadenosine. HEPES. 4-(2- ... Figure 4 Time course of agonist-induced AC sensitization. A, Transfected CHO cells were treated with 10 μm NECA at 37° for the ... 3). Therefore, the ability of chronic A3AR activation to sensitize AC stimulation is not a result of Gidown-regulation and ... The cell line used for these experiments bound the A3AR agonist radioligand125I-AB-MECA with high affinity (Kd = 1.24 ± 0.41 nm ...
http://molpharm.aspetjournals.org/content/52/4/632 List of MeSH codes (D03) - Wikipedia
2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 --- sparteine MeSH D03.438. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 --- 4-chloro-7-nitrobenzofurazan MeSH D03.383. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
US5565462A - Composition for topical treatment of psoriasis and atopic dermatitis comprising a xanthine derivative
-...
2-Polycyclic propynyl adenosine analogs having A2A agonist activity FR2884419A1 (en) * 2005-04-19. 2006-10-20. Galderma Sa. ... 2-Polycyclic propynyl adenosine analogs having A2A agonist activity US20090042901A1 (en) * 2005-02-02. 2009-02-12. Kowa Co., ... Substituted 4--piperidine-1-carboxylic acid esters as a2ar agonists US20110129546A1 (en) * 2008-06-20. 2011-06-02. Ignacio ... Substituted 4--piperidine-1-carboxylic acid esters as a2ar agonists US20110129546A1 (en) * 2008-06-20. 2011-06-02. Ignacio ...
https://patents.google.com/patent/US5565462?oq=flatulence Plus it
d-Pen2,d-Pen5]-enkephalin. ICI-174864. N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH. TIPP. H-Tyr-Tic-Phe-Phe-OH. DOR. δ-opioid receptor. ... 4-[(αR)-α-((2S,5R)-4-ally1-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide. BW373U86. (±)-4-((α-R*)-α-((2S*,5 ... 4; Table 2). Importantly, the EC50 for G-protein activation by TIPP in this assay was similar to its affinity (Ki) for δ-opioid ... guanosine 5′-O-(3-[35S]thio)triphosphate. KRHB. Krebs-Ringer-HEPES buffer. GppNHp. 5′-guanylylimidodiphosphate. SNC80. (+)- ...
http://jpet.aspetjournals.org/content/301/2/661 Plus it
2. The P20 responses to S1 and S2 for E1 and E5 are displayed for each of the habituation and stress days. Both genotypes are ... 4. For the N40 component of the habituation trials, S1 during E1 on the stress day reduced to the level of S2. There was no ... 3. For the P20 component of habituation trials, only the NR1neo(−/−) mice showed a reduction in amplitude during E1 on the ... 3). However, there were no significant three-way interactions among other sets of variables (Table 1). The NR1neo(−/−) mice ...
http://jpet.aspetjournals.org/content/331/1/308
Monocalcium Phosphate Manufacturers, Monocalcium Phosphate Suppliers, Exporters
1-tert-butoxy-2-methyl-1-oxopropan-2-yl)ox, (2Z,4Z)-2,4-hexadienedinitrile, (2a,6a,8a,9ab)-hexahydro-8-hydroxy-2,6-methano-2h ... p-methoxybenzyl)-3-isopropyl-piperazi, (R)-N-(tert-Butoxycarbonyl)-tert-leucine, (R)-N-4-Benzyl-2-phenylpiperazine, (R)-N-Boc-2 ... imidazolidinone, 1-(1,2-Benzisothiazol-3-yl) Piperazine, 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dio, 1-(2,3-Dichloro ... p-methoxybenzyl)-3-isopropyl-piperazi, (S)-N,N-dimethylpiperidine-3-carboxamide, (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine- ...
https://www.tradeindia.com/manufacturers/monocalcium-phosphate.html
Spectral Database Index:
IR - Industrial Chemicals, Basic Organic Compounds - Wiley
4-oxa-heptane-2,6-diol, (2S,6S)-. 4-tert-Butylaniline; 4-tert-Butylaniline; Aniline, p-tert-butyl-; Benzenamine, 4-(1,1- ... trans-1,2-Dichloroethylene; Ethene, 1,2-dichloro-, (trans)-. Please note that this spectral library may contain trade names ... 1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane; Urotropine. 1,3,5-Triazine-2,4,6-triamine; 2,4,6-Triamino-1,3,5-triazine; Melamine ... 2,6-Dimethyl-N,N-dimethylaniline; Aniline, N,N,2,6-tetramethyl-; Benzenamine, N,N,2,6-tetramethyl-; N,N-Dimethyl-2,6-xylidene. ...
http://www.knowitall.com/literature/indices/Spectral_Index.asp?cc=HLX
Indian Patents. 234346:3, 4-DISUBSTITUTED 1H-PYRAZOLE COMPOUNDS AND THEIR USE AS CYCLIN DEPENDENT KINASES (CDK) AND GLYCOGEN...
benzyl groups such as a/?flra-methoxybenzyl (PMB) group and tetrahydropyranyl (THP) groups.. A carboxylic acid group may be ... as a t-butoxy amide (-NHCO-OC(CH3)3, -NH-Boc); a 2-biphenyl-2-propoxy amide (-NHCO-OC(CH3)2C6H4C6H5, -NH-Bpoc), as a 9- ... imidazolidinone, oxazoline, thiazoline, 2-pyrazoline, pyrazolidine, piperazine, and N-ali. One preferred sub-set of non- ... Table 4. Example No. Method of Preparation LCMS. 44©-/1y. lengths), 70% ethyl acetate: hexane (10 column lengths) to give 1.25 ...
http://www.allindianpatents.com/patents/234346-3-4-disubstituted-1h-pyrazole-compounds-and-their-use-as-cyclin-dependent-kinases-cdk-and-glycogen-synthase-kinase-3-gsk-3-modulators
NEGATIVE RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN - Patent application
... n-butoxy group or tert-butoxy group, and most preferably a methoxy group or an ethoxy group. [0309]The halogen atom, with which ... 0340]n4 is preferably 0 to 2, and more preferably 0 or 1. [0341]n5 is preferably 0 or 1, and more preferably 0. [0342]n6 is ... 0018][Non-Patent Document 2] [0019]Proceedings of SPIE (U.S.), vol. 4690, pp. 76-83 (2002) [0020][Patent Document 1] [0021] ... R3' and R4' may be either the same or different, and are preferably the same. [0384]v is either 0 or an integer from 0 to 2, ...
http://www.patentsencyclopedia.com/app/20090111054 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE Manufacturer,1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE Supplier
... supplier and exporter of 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE at the best price. ... 2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE (CAS No.5815-08-7) AL0941 ...
http://www.alphachemikaindia.com/1-tert-butoxy-n-n-n-n-tetramethyl-methanediamine-2775414.html Di-O-isopropylidene-α-D-glucofuranose Manufacturer,Di-O-isopropylidene-α-D-glucofuranose Supplier
2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... 1-tert-BUTOXY-N,N,Nâ Nâ -TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... WGK 3 highly water endangering. Disposal. 3. Relatively unreactive organic reagents should be collected in container A. If ...
http://www.alphachemikaindia.com/di-o-isopropylidene-d-glucofuranose-579414.html Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [<sup>3</sup>H]-rolipram from high...
Y1 - 2010/2/10. N2 - The aim of the present study was to investigate the mode of action of luteolin on phisphodiesterase (PDE) ... 於: European Journal of Pharmacology, 卷 627, 編號 1-3, 10.02.2010, p. 269-275.. 研究成果: 雜誌貢獻 › 文章 ... Yu MC, Chen JH, Lai CY, Han CY, Ko W-C. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3 ... The EC50 (PDE4H) values of luteolin and Ro 20-1724, a selective PDE4 inhibitor, for displacing 2 nM [3H]-rolipram binding were ...
https://tmu.pure.elsevier.com/zh/publications/luteolin-a-non-selective-competitive-inhibitor-of-phosphodiestera Mechanism of the luteolytic action of prostaglandin F-2 alpha in the rat.<...
Lahav, M. ; Davis, J. S. ; Rennert, H. / Mechanism of the luteolytic action of prostaglandin F-2 alpha in the rat. In: Journal ... Lahav M, Davis JS, Rennert H. Mechanism of the luteolytic action of prostaglandin F-2 alpha in the rat. Journal of reproduction ... Lahav, M., Davis, J. S., & Rennert, H. (1989). Mechanism of the luteolytic action of prostaglandin F-2 alpha in the rat. ... Lahav, M, Davis, JS & Rennert, H 1989, 'Mechanism of the luteolytic action of prostaglandin F-2 alpha in the rat.', Journal of ...
https://nebraska.pure.elsevier.com/en/publications/mechanism-of-the-luteolytic-action-of-prostaglandin-f-2-alpha-in-
Rat homologs of the Drosophila dunce gene code for cyclic AMP phosphodiesterases sensitive to rolipram and RO 20-1724
The dunce locus of Drosophila melanogaster codes for a low Km, cAMP phosphodiesterase. The correct function of this gene is required for normal learning and memory activity in flies, because dunce mutants fail in tests of behavioral conditioning. These observations have indicated that cAMP regulation is an important aspect of the biochemistry underlying learning and memory processes in insects. To determine whether the locus is functionally conserved in mammals, we have expressed dunce gene homologs from the rat in a yeast expression system. We find that the rat homologs encode low Km, cAMP phosphodiesterases similar to that coded for by the Drosophila dunce+ gene and, more importantly, that the mammalian enzymes are inhibited by rolipram and RO 20-1724, drugs with antidepressant properties. Surprisingly, the dunce-encoded phosphodiesterase was not inhibited by rolipram or RO 20-1724. These findings suggest that the phosphodiesterases, through their regulation of cAMP levels, influence learning ...
https://vivo.scripps.edu/display/e6n328786 Silver Dichromate Manufacturer, Silver Dichromate Supplier
2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
http://www.alphachemikaindia.com/silver-dichromate-3787597.html BENZIDINE (powder) Extra Pure Manufacturer,BENZIDINE (powder) Extra Pure Supplier
2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
http://www.alphachemikaindia.com/benzidine-powder-extra-pure-2755050.html AMARANTH Manufacturer,AMARANTH Supplier
2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
http://www.alphachemikaindia.com/amaranth-2711313.html AMIDO BLACK 10B (For Molecular Biology) Manufacturer,AMIDO BLACK 10B (For Molecular Biology) Supplier
2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
http://www.alphachemikaindia.com/amido-black-10b-for-molecular-biology--3850224.html AMMONIUM (+) TARTRATE Manufacturer,AMMONIUM (+) TARTRATE Supplier
2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
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2S,2'S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine *L-Hydroxyproline ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIETHYLENE GLYCOL MONO BUTYL ETHER. *2,4-DIMETHYLPHENOL ... 1-tert-BUTOXY-N,N,N'N'-TETRAMETHYL METHANEDIAMINE. *AL0942 *tert-BUTYL ACETATE ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine *(2R,4R)-(+)-4-Diphenylphosphino2-diphenylphosphino ...
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- This is reflected in notable pharmacological differences, in particular, a 100-1000-fold-lower affinity of the rat A 3 AR for certain xanthine compounds compared with the recombinant human and sheep receptors ( 1 , 5-7 ). (aspetjournals.org)
- This invention relates to pyrazole compounds that inhibit or modulate the activity of cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3), to the use of the compounds in the treatment or prophylaxis of disease states or conditions mediated by cyclin dependent kinases and glycogen synthase kinase-3, and to novel compounds having cyclin dependent kinase or glycogen synthase kinase-3 inhibitory or modulating activity. (allindianpatents.com)
- Although several studies have detailed the mechanisms underlying agonist-mediated desensitization of the rat A 3 AR, the regulation of the human A 3 AR, which displays only a 70% amino acid identity with the rat homologue, has not been addressed. (aspetjournals.org)
- We demonstrated previously that prolonged agonist exposure of CHO cells expressing a recombinant rat A 3 AR results in a desensitization of receptor function that is associated with the down-regulation of specific G protein subunits ( 9 ). (aspetjournals.org)
- The purpose of this study was to examine the properties of TIPP at selected points of the signal transduction pathway (i.e., receptor binding, G-protein activation, and effector regulation) in GH 3 DORT cells (GH 3 cells expressing δ-opioid receptors) and compare them with that of an established δ-opioid agonist, [ d -Pen 2 , d -Pen 5 ]-enkephalin (DPDPE). (aspetjournals.org)
- Monocalcium Phosphate Monocalcium phosphate is a chemical compound with the formula Ca(H2PO4)2. (tradeindia.com)
- and in said formula (f2-0-3), R 51 and R 52 each independently represents a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms, a fluorine atom or a fluorinated lower alkyl group, m f and n f each independently represents an integer of 0 to 5 (provided that m f +n f ≧1), and q' represents an integer of 0 to (patentsencyclopedia.com)
- 5. A negative resist composition according to claim 4, wherein said fluorine-containing resin component (F) comprises said structural unit (f1), and a structural unit (f2-1), which is represented by said general formula (f2-0), in which at least one of said R 1 to R 4 is an alkali-soluble group represented by said general formula (f2-0-1). (patentsencyclopedia.com)
- The inability of the sensitization process to alter the AC activity obtained in the presence of manganese chloride suggests that prolonged A 3 AR activation increases the coupling efficiency between G s and AC catalytic units. (aspetjournals.org)
- these include cardioprotection and neuroprotection from prolonged ischemia, bronchoconstriction, mast cell and eosinophil activation, and induction of hypotension ( 1-3 ). (aspetjournals.org)
- In assays measuring G-protein activation, TIPP failed to stimulate guanosine 5′- O -(3-[ 35 S]thio)triphosphate ([ 35 S]GTPγS) binding in membrane preparations, which is consistent with an antagonist profile. (aspetjournals.org)
- The suppression by PGF-2 alpha of luteal cAMP is therefore apparently not mediated by phospholipase C activation but two phosphodiesterase inhibitors, 3-isobutyl-1-methylxanthine and Ro-20-1724, abolished the inhibitory effect of PGF-2 alpha. (elsevier.com)
- In isolated CL of 2 and 10 days of age, depletion of extracellular calcium, or addition of calmodulin inhibitors or of 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxy-benzoate (TMB-8), did not prevent the suppressive effect of PGF-2 alpha. (elsevier.com)