Inhibitor of phosphodiesterases.
Compounds based on reduced IMIDAZOLINES which contain no double bonds in the ring.
Cell surface receptors for EPOPROSTENOL. They are coupled to HETEROTRIMERIC G-PROTEINS.
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH ... quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 - sparteine MeSH D03.438. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 - 4-chloro-7-nitrobenzofurazan MeSH D03.383. ...
2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 - fanft MeSH D03.383.312.649.308 - furagin MeSH ... quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 - sparteine MeSH D03.438. ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.129.462.580.400 - 4-chloro-7-nitrobenzofurazan MeSH D03.383. ...
3AMP/*metabolismAnimalsCulturedCyclicFemaleFollicle/drugGMP/*physiologyGapHormone/pharmacology/physiologyHumansJunctions/drug ... Circulation 87 (2): 454-63 (February 1993. )Ungerer, M Bohm, M Elce, J S Erdmann, E Lohse, M J In Vitro Research Support, Non-U ... Skin Pharmacol 2 (2): 61-7 (1989. )Meier, F Gross, E Klotz, K N Ruzicka, T Comparative Study Research Support, Non-U.S. Govt ... Cyclic4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacologyAMPAMP/metabolismAdenosine/analogsAdenylateAnimalsAtria/* ...
1-Methyl-3-isobutylxanthine/pharmacologyAMP-DependentAMP/metabolismAcidAdenylateAdrenergicAminoBlotting,CellCyclase/metabolism ... Am J Physiol 263 (2 Pt 1): C502-8 (August 1992. )Spielman, W S Klotz, K N Arend, L J Olson, B A LeVier, D G Schwabe, U R01 DK- ... Cyclic4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacologyAMPAMP/metabolismAdenosine/analogsAdenylateAnimalsAtria/* ... Arrestins*Cyclic5-O-(3-Thiotriphosphate)/pharmacologyAMP-DependentAcidAdenylateAminoAnimalsAntibodiesAntigens/genetics/* ...
This graph shows the total number of publications written about "Carbimazole" by people in this website by year, and whether "Carbimazole" was a major or minor topic of these publications ...
1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine ...
Dawson R, Diacon AH, Everitt D, van Niekerk C, Donald PR, Burger DA, Schall R, Spigelman M, Conradie A, Eisenach K, Venter A, Ive P, Page-Shipp L, Variava E, Reither K, Ntinginya NE, Pym A, von Groote-Bidlingmaier F, Mendel CM. Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis. Lancet. 2015 May 02; 385(9979):1738-1747 ...
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. ... Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo. Mol Carcinog. 2021 03; 60( ... That Antagonize Protease-Activated Receptor 4. J Med Chem. 2022 07 14; 65(13):8843-8854. ...
2-Butyl-4-chloro-1-((2-(1H-etrazol-5-yl) (1,1-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol ...
Bascom R, Pipkorn U, Proud D, Dunnette S, Gleich GJ, Lichtenstein LM, Naclerio RM. Major basic protein and eosinophil-derived neurotoxin concentrations in nasal-lavage fluid after antigen challenge: effect of systemic corticosteroids and relationship to eosinophil influx. J Allergy Clin Immunol. 1989 Sep; 84(3):338-46 ...
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. ...
This graph shows the total number of publications written about "Idazoxan" by people in this website by year, and whether "Idazoxan" was a major or minor topic of these publications ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine. *L - Hydroxyproline ... 1-tert-BUTOXY-N,N,NN-TETRAMETHYL METHANEDIAMINE. *AL0942 CHEMICAL. *tert - BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIMETHYL GLYOXIME DISODIUM SALT. *1,3-DIOXOLANE ... 2-2- Dichloroacetamide. CAS No : Dichloroacetamide. Minimum Order Quantity : 500. Send Inquiry ...
2S,2S)-(-)-2-Hydroxymethyl-1-[(1-methylpyrrolidine- 2-yl)-methyl]-pyrrolidine. *L - Hydroxyproline ... 1-tert-BUTOXY-N,N,NN-TETRAMETHYL METHANEDIAMINE. *AL0942 CHEMICAL. *tert - BUTYL ACETATE ... N,N-DIMETHYL IMIDAZOLIDINONE GC. *DIMETHYL GLYOXIME DISODIUM SALT. *1,3-DIOXOLANE ... 2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenyl phospino methyl-pyrrolidine. *(2R,4R)-(+)-4-Diphenylphosphino2- ...
This graph shows the total number of publications written about "Fluspirilene" by people in Harvard Catalyst Profiles by year, and whether "Fluspirilene" was a major or minor topic of these publication ...
This graph shows the total number of publications written about "Imidazolidines" by people in this website by year, and whether "Imidazolidines" was a major or minor topic of these publications ...
Wood SK, Zhang XY, Reyes BA, Lee CS, Van Bockstaele EJ, Valentino RJ. Cellular adaptations of dorsal raphe serotonin neurons associated with the development of active coping in response to social stress. Biol Psychiatry. 2013 Jun 01; 73(11):1087-94 ...
The membrane permeant analog of cyclic-3,5-AMP (cAMP), N6,2-O-dibutyryl-AMP (db-cAMP), mimicked the facilitatory effect of ... 2007 Jun 8;146(4):1772-84. doi: 10.1016/j.neuroscience.2007.04.001. Epub 2007 May 3. ... Isoproterenol-induced enhancement of eEPSPs was promoted by pre-application of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone ( ... A selective protein kinase A inhibitor, N-[2-(p-bromocinnamylamino)ethyl]-5-soquinolinesulfonamide (H-89), inhibited the ...
1989;53(3):197-203. doi: 10.1016/0079-6107(89)90002-3. Prog Biophys Mol Biol. 1989. PMID: 2577126 Review. No abstract available ... 2010 Jan 27;314(2):170-83. doi: 10.1016/j.mce.2009.07.010. Epub 2009 Jul 19. Mol Cell Endocrinol. 2010. PMID: 19622385 Free PMC ... Nalepa I, Kowalska M, Kreiner G, Vetulani J. Nalepa I, et al. J Neural Transm (Vienna). 1997;104(4-5):535-47. doi: 10.1007/ ... 1995 Nov;282(2):219-26. doi: 10.1007/BF00319113. Cell Tissue Res. 1995. PMID: 8565052 ...
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Preferred Term Term UI T036802. Date02/08/1989. LexicalTag NON. ThesaurusID NLM ... 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Preferred Concept UI. M0019225. Registry Number. 29925-17-5. Scope Note. ... 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone. Tree Number(s). D03.383.129.308.100. Unique ID. D012368. RDF Unique Identifier ... 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-. Previous Indexing. Benzyl Compounds (1972-1974). Ethers (1974). ...
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Preferred Term Term UI T036802. Date02/08/1989. LexicalTag NON. ThesaurusID NLM ... 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Preferred Concept UI. M0019225. Registry Number. 29925-17-5. Scope Note. ... 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone. Tree Number(s). D03.383.129.308.100. Unique ID. D012368. RDF Unique Identifier ... 2-Imidazolidinone, 4-((3-butoxy-4-methoxyphenyl)methyl)-. Previous Indexing. Benzyl Compounds (1972-1974). Ethers (1974). ...
4. Effects of culturing NG108-15 cells with PGE, on the kinet- ics of PGE,-stimulated adenylate cyclase activity A. Cells were ... 2:99- 114 (1976). 27. Kebabian, J. W., M. Zatz, J. A. Romero, and J. Axelrod. Rapid changes in rat pineal -adrenergic receptor ... Addition to cells Kar Vinax Stage 1, Stage 2, 0-16 hr 16-28 hr pM pmoles PGE, cyclic AMP/min/ mg protein 4 None 0.18 72.8 0.25 ... 3:69- 83 (1977). 22. Mickey, J. V., R. Tate, D. Mullikin, and R. J. Lefkowitz. Regulation of adenylate cyclase-coupled beta ...
27 N0000170401 D-Ala(2),MePhe(4),Met(0)-ol-enkephalin N0000168380 D-Alanine Transaminase N0000167841 D-Amino-Acid Oxidase ... 6 N0000179130 FDC blue lake no.2 N0000179385 febuxostat N0000007445 felbamate N0000006368 Felodipine N0000170339 Felypressin ... 2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol N0000179007 1 alpha-hydroxyergocalciferol N0000179008 1,1,1- ... quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- N0000178847 2S Albumins, Plant N0000170710 3 ...
5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole) src Homology Domains G6.184.580.709.610.800 G6.184.603.790.709.610.800 Starch D9.203. ... D9.400.420.800 RNA 3 End Processing G6.535.839.225 RNA Editing G6.535.839.250 RNA Processing, Post-Transcriptional G6.535.839 ... 4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer D3.383.773.953 D3.383.773.170 3-O- ... 4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester) Bears B1.150.900.649.147.125 B1.150.900.649. ...
This graph shows the total number of publications written about "Idazoxan" by people in this website by year, and whether "Idazoxan" was a major or minor topic of these publications ...
Ancha HR, Kurella RR, Stewart CA, Damera G, Ceresa BP, Harty RF. Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway. Int J Biochem Cell Biol. 2007; 39(11):2143-52 ...
A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the ...
Distinguish from 1,2-diazole (PYRAZOLES).. Allowable Qualifiers:. AD administration & dosage. AE adverse effects. AG agonists. ... Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. ... Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. ... We invite you to complete a survey that will take no more than 3 minutes.. Go to survey ...
Garcia-Contreras L, Sung JC, Muttil P, Padilla D, Telko M, Verberkmoes JL, Elbert KJ, Hickey AJ, Edwards DA. Dry powder PA-824 aerosols for treatment of tuberculosis in guinea pigs. Antimicrob Agents Chemother. 2010 Apr; 54(4):1436-42 ...
1-tert-BUTOXY-2-PROPANOL. ICSC. : 1615. Propylene glycol tert-butyl ether. 1-Methyl-2-tert-butoxyethanol. 1-(1,1-Dimethylethoxy ... 1-Butoxy-2-propanol , C7H16O2 - PubChem. 1-Butoxy-2-propanol , C7H16O2 , CID 21210 - structure, chemical names, physical and ... 1-BUTOXY-*2-Propanol, 1-chloro-*2-Propanol, 1-chloro-, 3-(C12-15-alkyloxy) derivs.*2-Propanol .... ... 2,3-Dichloro-1-propanol 11539-F. Testing Status of 2,3-Dichloro-1-propanol 11539-F. CASRN: 616-23-9. Formula: C3-H6-Cl2-O. ...
  • Stork, Stefan Boivin, Valerie Horf, Rudiger Hein, Lutz Lohse, Martin J Angermann, Christiane E Jahns, Roland Research Support, Non-U.S. Gov't United States American heart journal Am Heart J. 2006 Oct;152(4):697-704. (bibsonomy.org)
  • Isoproterenol-induced enhancement of eEPSPs was promoted by pre-application of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro 20-1724), a cAMP-specific phosphodiesterase inhibitor. (nih.gov)
  • The amplification of the beta-adrenergic cAMP response by these agents also occurred in the presence of isobutylmethylxanthine (10(-3) M) and Ro 20-1724 (10(-4) M), an observation suggesting that inhibition of cAMP phosphodiesterase activity is not the mechanism of action. (nih.gov)
  • A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. (rush.edu)
  • Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS. (lookformedical.com)
  • Drugs that bind to and block the activation of ADRENERGIC BETA-3 RECEPTORS. (lookformedical.com)
  • Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. (bvsalud.org)
  • A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity. (ucdenver.edu)
  • A selective protein kinase A inhibitor, N-[2-(p-bromocinnamylamino)ethyl]-5-soquinolinesulfonamide (H-89), inhibited the excitatory effect by isoproterenol. (nih.gov)
  • Activation of adenylate cyclase of NG108-15 neuroblastoma-glioma hybrid cells by prostaglandin E, resulted in the gradual loss of basal adenylate cyclase activity as well as enzyme activity stimulated by prostaglandin E), 2-chloroadenosine, NaF, or both pros- taglandin E, and guanyl-5'-yl imidodiphosphate. (nih.gov)
  • The membrane permeant analog of cyclic-3',5'-AMP (cAMP), N6,2'-O-dibutyryl-AMP (db-cAMP), mimicked the facilitatory effect of isoproterenol. (nih.gov)
  • The cAMP response following cholera toxin pretreatment (60-120 min) was rapidly and markedly enhanced by alpha 1-adrenergic agonists (cirazoline greater than PE greater than methoxamine), by phorbol esters (PMA greater than 4 beta-phorbol 12,13,-dibutyrate much greater than 4 alpha-phorbol 12,13-didecanoate), and by synthetic diacylglycerols (1,2-dioctanoylglycerol greater than 1-oleoyl 2-acetylglycerol much greater than diolein). (nih.gov)
  • Exposure of NG108-15 cells to 8-Br cyclic AMP also resulted in the loss of basal, prostaglandin Ej-stimulated, and 2-chlo- roadenosine-stimulated adenylate cyclase activities. (nih.gov)
  • In contrast, exposure of NG108-15 cells to 2-chloroadenosine resulted in the rapid loss of response to 2-chloroadenosine with a half- life of 1.8 hr, but prostaglandin E,-stimulated and basal enzyme activities decreased only slightly. (nih.gov)
  • The cells were centrifuged for 4 min at 1000 x g, and the cell pellets were frozen in Dry Ice and stored over liquid nitrogen. (nih.gov)