3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.Oxidoreductases, O-Demethylating: Drug metabolizing enzymes which oxidize methyl ethers. Usually found in liver microsomes.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Government Agencies: Administrative units of government responsible for policy making and management of governmental activities.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.HEPES: A dipolar ionic buffer.Capillary Action: A phenomenon in which the surface of a liquid where it contacts a solid is elevated or depressed, because of the relative attraction of the molecules of the liquid for each other and for those of the solid. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Calcineurin: A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.Corpus Striatum: Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.IndianaPhosphocreatine: An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Calcium Channels: Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Calcium Channel Agonists: Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. They have been used primarily in experimental studies in cell and tissue culture.Calcium Channels, L-Type: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.Sodium Channel Agonists: A class of drugs that stimulate sodium influx through cell membrane channels.Antazoline: An antagonist of histamine H1 receptors.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Tissue Scaffolds: Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.Bioreactors: Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Nanofibers: Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Potassium Channels, Voltage-Gated: Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Ion Channel Gating: The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Undaria: A genus of BROWN ALGAE, in the family Alariaceae, native to Japan, Korea, and China. The edible SEAWEED Undaria pinnatifida is also called wakame.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.
... trifluoromethyl)phenyl)-, methyl ester MeSH D03.383.725.210 --- dimethindene MeSH D03.383.725.220 --- 2,2'-dipyridyl MeSH ... niflumic acid MeSH D03.066.515.635 --- pipemidic acid MeSH D03.066.515.650 --- piromidic acid MeSH D03.066.515.950 --- ... trifluoromethyl)phenyl)-, methyl ester MeSH D03.383.725.547.950 --- xanthinol niacinate MeSH D03.383.725.565 --- nicotinyl ... trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 --- epirizole MeSH D03.383.129.539.487 --- indazoles MeSH ...
The drug combination hyoscyamine/hexamethylenetetramine/phenyl salicylate/methylene blue/benzoic acid (trade names Methylphen, Prosed DS) is used for the treatment of urinary tract infections. Hyoscyamine is an antimuscarinic agent which reduces spasms of the urinary bladder's smooth muscles. Hexamethylenetetramine (also called methenamine) is hydrolyzed to formaldehyde, which acts as a bactericidal or bacteriostatic agent. Phenyl salicylate is a mild pain reliever from the class of nonsteroidal anti-inflammatory drugs (NSAIDs). Methylene blue is a weak antiseptic. Benzoic acid lowers the pH in the urine, which is necessary for hexamethylenetetramine hydrolysis, and generates an unfavourable environment for bacteria. Prosed EC and Prosed ED delayed-release tablets additionally contain atropine, which is closely related to hyoscyamine and has ...
The Japan Network Information Center (JPNIC) is the National Internet Registry in Japan that manages several aspects of Internet operations, including the allocation of IP addresses and AS numbers. Historically, JPNIC managed the .jp top-level domain; on 2003-06-30 the management of the .jp domain was transferred to the Japan Registry Service. JPNIC is a non-profit organization, made up of many members of the Japanese Internet community that have a stake in the internet in Japan. As such, JPNIC provides information, research, and education services to its members, and to the Internet community at large. ...
... (EPIC) is an independent non-profit research center in Washington, D.C. EPIC's mission is to focus public attention on emerging privacy and related human rights issues. EPIC works to protect privacy, freedom of expression, and democratic values, and to promote the Public Voice in decisions concerning the future of the Internet. EPIC is involved with wide range of civil liberties, consumer protection, and human rights issues. EPIC has pursued several successful consumer privacy complaints with the US Federal Trade Commission, concerning Snapchat (faulty privacy technology), WhatsApp (privacy policy after acquisition by Facebook), Facebook (changes in user privacy settings), Google (roll-out of Google Buzz), Microsoft (Hailstorm log-in), and Choicepoint (sale of personal information to identity thieves). EPIC has also prevailed in significant Freedom of Information Act cases against the CIA, the DHS, the Dept. of Education, the FBI, the NSA, the ODNI, and the ...
The package insert for Gonal-F states that based on physio-chemical tests and bioassays that follitropin beta and follitropin alfa are indistinguishable. Two studies showed no difference.[5][6] However, a more recent study showed there may be a slight clinical difference, with the alfa form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels.[7]. The package insert for Puregon states that structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (hFSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural hFSH. However, these small differences do not affect the bioactivity compared to natural hFSH.. ...
The Information Services Procurement Library (ISPL) is a best practice library for the management of Information Technology related acquisition processes. It helps both the customer and supplier organization to achieve the desired quality using the corresponded amount of time and money by providing methods and best practices for risk management, contract management, and planning. ISPL focuses on the relationship between the customer and supplier organization: It helps constructing the request for proposal, it helps constructing the contract and delivery plan according to the project situation and risks, and it helps monitoring the delivery phase. ISPL is a unique Information Technology method because where most other Information Technology methods and frameworks focus on development (e.g. DSDM, RUP), ISPL focuses purely on the procurement of information services. The target audience for ISPL consists of procurement managers, acquisition managers, programme managers, contract managers, facilities ...
... (trade name Emetrol) is an over-the-counter antiemetic taken to relieve nausea and vomiting. Made by WellSpring Pharmaceutical Corporation, it was formerly distributed by McNeil Consumer Healthcare. Emetrol was created by Kinney and Company of Columbus, Indiana and was first used in 1949. It is a phosphorated carbohydrate solution, and comes in syrup form. Since Emetrol contains fructose it is contraindicated for people with hereditary fructose intolerance (HFI). In diabetes patients, it can cause potentially harmful hyperglycaemia (high blood sugar). http://emetrol.com/history.html Consumer Drug Information Official ...
The IANA function was originally performed by USC Information Sciences Institute (ISI), and it delegated portions of this responsibility with respect to numeric network and autonomous system identifiers to the Network Information Center (NIC) at Stanford Research Institute (SRI International) in Menlo Park, California. ISI's Jonathan Postel managed the IANA, served as RFC Editor and performed other key roles until his premature death in 1998.[112] As the early ARPANET grew, hosts were referred to by names, and a HOSTS.TXT file would be distributed from SRI International to each host on the network. As the network grew, this became cumbersome. A technical solution came in the form of the Domain Name System, created by ISI's Paul Mockapetris in 1983.[113] The Defense Data Network-Network Information Center (DDN-NIC) at SRI handled all registration services, including the top-level domains (TLDs) of .mil, .gov, .edu, .org, .net, .com and .us, root nameserver administration and Internet number ...
APNIC was established in 1992, by the Asia Pacific Coordinating Committee for Intercontinental Research Networks (APCCIRN) and the Asia Pacific Engineering and Planning Group (APEPG). These two groups were later amalgamated and renamed the Asia Pacific Networking Group (APNG). It was established as a pilot project to administer address space as defined by RFC-1366, as well as encompassing a wider brief: "To facilitate communication, business, and culture using Internet technologies".. In 1993, APNG discovered they were unable to provide a formal umbrella or legal structure for APNIC, and so the pilot project was concluded, but APNIC continued to exist independently under the authority of IANA as an 'interim project'. At this stage, APNIC still lacked legal rights, a membership, and a fee structure.. In 1995, the inaugural APNIC meeting was held in Bangkok. This was a two-day meeting, run by volunteers, and was free to attend. Voluntary donations were sought according to the size of the ...
... on Brasilian Internet-maatunnus. Sitä ylläpiti aiemmin Brazilian Internet Steering Committee (Comitê Gestor da Internet no Brasil) ja vuodesta 2005 Brazilian Network Information Center (Núcleo de Informação e Coordenação do Ponto br). Rekisteröinti edellyttää kontaktia Brasiliaan. Verkkotunnuksissa voi käyttää portugalin kielen merkkejä. Tunnuksella on lukuisia toisen tason tunnuksia ja niiden käyttöön on tiukat säädökset. .br-tunnus otettiin käyttöön 1989. ...
The precursor of the National Library of Medicine, established in 1836, was the Library of the Surgeon General's Office, a part of the office of the Surgeon General of the United States Army. The Armed Forces Institute of Pathology and its Medical Museum was founded in 1862 as the Army Medical Museum. Throughout their history the Library of the Surgeon General's Office and the Army Medical Museum often shared quarters. From 1866 to 1887, they were housed in Ford's Theatre after production there was stopped, following the assassination of President Abraham Lincoln. In 1956, the library collection was transferred from the control of the U.S. Department of Defense to the Public Health Service of the Department of Health, Education, and Welfare and renamed the National Library of Medicine, through the instrumentality of Frank Bradway Rogers, who was the director from 1956 to 1963. The library moved to its current quarters in Bethesda, Maryland, on the campus of the National Institutes of Health, in ...
The precursor of the National Library of Medicine, established in 1836, was the Library of the Surgeon General's Office, a part of the office of the Surgeon General of the United States Army. The Armed Forces Institute of Pathology and its Medical Museum were founded in 1862 as the Army Medical Museum. Throughout their history the Library of the Surgeon General's Office and the Army Medical Museum often shared quarters. From 1866 to 1887, they were housed in Ford's Theatre after production there was stopped, following the assassination of President Abraham Lincoln. In 1956, the library collection was transferred from the control of the U.S. Department of Defense to the Public Health Service of the Department of Health, Education, and Welfare and renamed the National Library of Medicine, through the instrumentality of Frank Bradway Rogers, who was the director from 1956 to 1963. The library moved to its current quarters in Bethesda, Maryland, on the campus of the National Institutes of Health, in ...
The Qidong protest was an environmental protest against a proposed waste water pipeline in the Chinese city of Qidong, Jiangsu province. The protest took place on 28 July 2012. The pipeline, which would have dumped industrial waste water into the sea, was to be part of a paper factory owned jointly by Japan's Oji Paper Company. Thousands of citizens took to the streets demanding the cancellation of the project, citing environmental concerns. An estimated 1,000 protesters stormed government offices, overturning vehicles, and forcing the city's mayor to strip off his shirt and instead wear a T-shirt with protest messages. Protests ended after the government promised to permanently suspend the project. The coastal city of Qidong is located at the mouth of the Yangtze River, approximately one hour north of Shanghai. The city's economy is centered largely on the fishing industry, and is a major source of lobster and shrimp exports. In 2007, the Oji Paper Company began construction of a paper mill ...
A third central London protest was organised for Tuesday 30 November, a day that saw cold temperatures and snow in the city. Protesters assembled at Trafalgar Square, but a police line prevented their march down Whitehall towards the Houses of Parliament; the NCAFC accused the Police of "pre-emptively block[ing]" the protest route.[52] Fearing that they would be kettled in the Square, protesters dispersed throughout the city center, pursued by police.[53] Other officers stood photographing and filming the students for later identification, while police vans blocked off certain streets.[54] Some protesters chanted "Peaceful protest! Peaceful protest!" and "no ifs, no buts, no education cuts", and others blew vuvuzelas and played reggae from portable stereo systems.[54] A BBC reporter talked to members of the demonstration, noting that while many desired a peaceful outcome, others believed that violent confrontation with the police was inevitable. Many were ...
... trifluoromethyl)phenyl)-, Methyl ester 3. 1-Ethyl-2-benzimidazolinone 4. Adenophostin A ... 1. Calcitriol [USAN:USP:INN:BAN:JAN] 2. 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-. 4-(2-( ...
Third order mesenteric arteries from male F344 rats, aged 2.5 - 3 months (young) and 22 - 26 months (old) were mounted on wire ... Third order mesenteric arteries from male F344 rats, aged 2.5 - 3 months (young) and 22 - 26 months (old) were mounted on wire ... Parallel to this reduction, the expression of Cav1.2 protein was reduced by 57 ± 5% in arteries from old rats compared to those ... trifluoromethyl) phenyl]-3-pyridinecarboxylic acid methyl ester.. References. Abernethy, D. R., and Schwartz, J. B. (1999). ...
1. The Na+-dependent inward currents underlying slow diastolic depolarization of sinoatrial (SA) node cells were examined. ... trifluoromethyl)phenyl)-, Methyl ester / pharmacology. Animals. Calcium Channel Agonists / pharmacology. Calcium Channel ... 3. In the ensemble average, the activation of ist was evident by depolarization beyond -70 mV, and the dynamic voltage range of ... 4. Cumulative histograms for both open and closed times were fitted with a sum of two exponential components. The slow time ...
... trifluoromethyl)phenyl)-, Methyl ester / pharmacology * Aniline Compounds / metabolism * Animals * Animals, Newborn ... Inhibition of the endoplasmic reticulum Ca(2+) ATPase by cyclopiazonic acid also induced [Ca(2+)](i) transients in astrocytes ... 1 School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, CF10 3US, Wales, Cardiff, UK. [email protected] ... This study indicates that Ca(2+) has a role in triggering Ca(2+) release from an inositol 1,4,5,-triphosphate sensitive store ...
... trifluoromethyl)phenyl)-, methyl ester MeSH D03.383.725.210 --- dimethindene MeSH D03.383.725.220 --- 2,2-dipyridyl MeSH ... niflumic acid MeSH D03.066.515.635 --- pipemidic acid MeSH D03.066.515.650 --- piromidic acid MeSH D03.066.515.950 --- ... trifluoromethyl)phenyl)-, methyl ester MeSH D03.383.725.547.950 --- xanthinol niacinate MeSH D03.383.725.565 --- nicotinyl ... trifluoromethyl)phenyl)-1h-pyrazol-3-amine MeSH D03.383.129.539.200 --- epirizole MeSH D03.383.129.539.487 --- indazoles MeSH ...
... trifluoromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester (BAYK) 8644 and 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H- ... 180N-methyl-d-glucamine (NMG), 40 HEPES, 4 MgCl2, 0-20 BAPTA, 12 phosphocreatine, 2 Na2ATP, 0.2 Na2GTP, and 0.1 leupeptin, pH ... 2 C,D). As shown in Figure 2 C,inset box plot, the median reduction in the amplitude of the slow tail current by NPA (10 μm) ... 3. The modulation is dependent on D2receptors. A, A plot of Ba2+ current tail amplitudes as a function of time (see Fig. 2 D). ...
... trifluoromethyl)phenyl)-, Methyl ester Firefly Luciferases Thymidine Kinase Sequence Deletion Nucleic Acid Regulatory Sequences ... The distal region does not confer a response to phorbol ester, while the proximal region is responsive to that treatment. ... The distal region does not confer a response to phorbol ester, while the proximal region is responsive to that treatment. ... The distal region does not confer a response to phorbol ester, while the proximal region is responsive to that treatment. ...
Bay K 8644 - CAS 93468-89-4 - Calbiochem CAS 93468-89-4 Synthetic dihydropyridine derivative that acts as an active Ca2+ slow ... trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester. Primary Target: L-type Ca2+ channel ... phenyl]-3-pyridinecarboxylic Acid Methyl Ester. Description. A synthetic dihydropyridine derivative that is an active Ca2+ slow ... 2°C to +8°C. Protect from Light. Protect from light. Do not freeze. Ok to freeze. Special Instructions. Following ...
... trifluoromethyl)-phenyl]-3-py rid ine carboxylic acid methyl ester (Bay K 8644), a calcium channel agonist, in alveolar type II ... methyl ester. * Molecular Weight. 356.3. * Chemical structure. * Molecular Formula. C16H15F3N2O4 ... Chen X et al (2008) Am J Physiol Heart Circ Physiol 294(5) : H2257-67. PubMedID: 18359894 ... Shin EJ et al (2004) Behav Brain Res 151(1-2) : 267-76. PubMedID: 15084442 ...
... trifluoromethyl)phenyl)-, Methyl ester. BW-755C. 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine. ... D12 - AMINO ACIDS, PEPTIDES, AND PROTEINS. Adaptor Proteins. Adaptor Proteins, Vesicular Transport. ... N-dimethyl-N-2-propenyl-), Dibromide. DDD. Dichlorodiphenyldichloroethane. ... carboxylic acid, 8-chloro-, 2-acetylhydrazide. Sch-23390. (R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7- ...
... trifluoromethyl)phenyl)-, Methyl ester Cell Line Poisons Guanidine Calcium Channel Blockers ... In contrast, we find that 3H-guanidinium which displays no selective toxicity between MDR+ and MDR- cells, shows no significant ... 1) were required for recognition by murine cells which express P-glycoprotein (p-gp)-mediated multidrug resistance (MDR). In ... 1) were required for recognition by murine cells which express P-glycoprotein (p-gp)-mediated multidrug resistance (MDR). In ...
... trifluoromethyl)phenyl)-, Methyl ester * Nitrendipine * Corpus Striatum * Alprostadil * Bradykinin * 1,4-dihydropyridine ...
... trifluoromethyl)phenyl)-, Methyl ester Nitrendipine Pineal Gland 23 Citations (Scopus) Transmembrane topology of Escherichia ... Glutamic Acid 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-( ... Yamada, H., Moriyama, Y., Maeda, M. & Futai, M., Jul 15 1996, In : FEBS Letters. 390, 1, p. 34-38 5 p.. Research output: ... Moriyama, Y., Yamada, H., Hayashi, M., Oda, T. & Yamaguchi, A., May 22 1998, In : Neuroscience Letters. 248, 1, p. 57-60 4 p.. ...
Gentaur Molecular products offer more than 3 million research antibodies, elisa kit, proteins and polyclonal, monoclonal ... trifluoromethyl) phenyl]-3-pyridinecarboxylic acid, methyl ester. K183-100 Active Caspase_3 Staining Kit, CaspGLOW Fluorescein ... 2112-20 Acetic Acid (50 mM) Ethanoic acid, methanecarboxylic acid, ethylic acid. ... 8-Dihydro-8-oxo-2-deoxyguanosine; sine; 8-OH-dG. 2177-5 8-Hydroxy-2-deoxyguanosine 8-Oxo-dG; 8-Oxo-7,8-dihydrodeoxyguanosine ...
1993 Sep-Oct;14(5):319-28. Research Support, U.S. Govt, P.H.S. ... trifluoromethyl)phenyl)-, Methyl ester/pharmacology. *Action ... Christ GJ1, Spray DC, Brink PR.. Author information. 1. Department of Urology, Albert Einstein College of Medicine/Montefiore ... J Androl. 1993 Sep-Oct;14(5):319-28.. Characterization of K currents in cultured human corporal smooth muscle cells.. ... Single channel recordings in the detached patch mode consistently revealed the presence of at least two K channels: 1) a KCa ...
... trifluoromethyl)phenyl)-, Methyl ester/pharmacology. *Animals. *Barium/metabolism. *Calcium Channel Blockers/pharmacology* ... Pollo A1, Lovallo M, Biancardi E, Sher E, Socci C, Carbone E. ... 1. Department of Anatomy and Human Physiology, Corso Raffaello ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... Pflugers Arch. 1993 Jun;423(5-6):462-71.. Sensitivity to dihydropyridines, omega-conotoxin and noradrenaline reveals multiple ...
5. The results provide novel evidence for a role for annexin 1 as a mediator of the inhibitory actions of glucocorticoids on ... 3. The inhibitory actions of the steroids on GH release elicited by the above secretagogues were effectively reversed by an ... 1. Our previous studies have identified a role for annexin 1 as a mediator of glucocorticoid action in the neuroendocrine ... 2. Rat anterior pituitary tissue responded in vitro to growth hormone releasing hormone, forskolin, 8-Bromo-cyclic adenosine ...
... trifluoromethyl)phenyl)-, Methyl ester, 8-Bromo Cyclic Adenosine Monophosphate, Animals, Calcium, Cells, Cultured, Colforsin, ...
... trifluoromethyl)phenyl)-, Methyl ester, Calcium, metabolism, Calmodulin, pharmacology, Cell Line, Dihydropyridines,... ... C Nelson 외 6 명 Nature 33회 피인용 Animals, Base Sequence, Gene Expression Regulation, Genes, Growth Hormone, genetics, Pituitary ... J I Morgan 외 1 명 Nature 132회 피인용 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-( ... start page previous page 1 2 3 4 5 6 7 8 next page end page ...
... trifluoromethyl)phenyl)-, Methyl ester / Valproic Acid / Octamer Transcription Factor-3 / Mice Limits: Animals Language: ... trifluoromethyl)phenyl)-, Methyl ester , Phthalimides , Tryptophan/analogs & derivatives , Valproic Acid , Octamer ... Small molecules such as BIX-01294, Bay K8644, RG-108 and valproic acid [VPA] are reported as effective molecules for enhancing ... Comparing the effects of small molecules BIX-01294, Bay K8644, RG-108 and valproic acid, and their different combinations on ...
... trifluoromethyl)phenyl)-, Methyl ester. *Amlodipine. *Dicarbethoxydihydrocollidine. *Felodipine. *Isradipine. *Nicardipine. * ... Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia. Brain Res. 2009 May 26; ...
... trifluoromethyl)phenyl)-, Methyl ester. *Amlodipine. *Dicarbethoxydihydrocollidine. *Felodipine. *Isradipine. *Nicardipine. * ...
... trifluoromethyl)phenyl)-, Methyl ester / Nifedipine Language: English Journal: Acta Pharmaceutica Sinica Year: 2008 Type: ... trifluoromethyl)phenyl)-, Methyl ester , Pharmacology , Aequorin , Pharmacology , Animals , Calcium , Metabolism , Calcium ... In Na+, K+ -free Tyrode s solution, the response of cardiomycytes in [Ca2+]i elevation to Str (10 micromol L(-1)) was ... 1)) , but had no obvious effects on the action of Str (10 micromol L(-1)). The elevation of [Ca2+]i caused by Str at all of the ...
Bay was released continually from scaffolds within the physiological range required for agonist activity (1-10 microM). Patch ... trifluoromethyl)phenyl)-, Methyl ester, Animals, Biocompatible Materials, Bioreactors, Calcium Channel Agonists, Calcium ... Channels, L-Type, Cell Line, Tumor, Delayed-Action Preparations, Drug Stability, Lactic Acid, Membrane Potentials, Osteoblasts ... Bay was released continually from scaffolds within the physiological range required for agonist activity (1-10 microM). Patch ...
... trifluoromethyl)phenyl)-, Methyl ester * Neurons * Spinal Trigeminal Nucleus 62 Scopus citations ... Inhibition of Gastric Acid Secretion by Peptide YY Is Independent of Gastric Somatostatin Release in the Rat. Greeley, G. H., ... Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach. Guo, Y. S., ... Udd, J. R., Singh, P., Townsend, C. M. & Thompson, J. C., Jan 15 1989, In : Cancer Research. 49, 2, p. 488-492 5 p.. Research ...
  • Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. (curehunter.com)
  • 2 Aminonicotinic acid CAS number is 5345 47 1 which is an important starting material for the synthesis of antibacterial and anti inflammatory drugs naphthyridinone There are three main synthetic methods the first one uses 3 cyanopyridine or 3 guanidinium pyridine or nicotinic acid as a raw material to activate the. (volsenchem.com)
  • Pyridine was discovered in 1. (chemchart.com)
  • Expression and analysis in vitro of recombinant UGT1A7, UGT1A9, UGT1A10, UGT2B7 and UGT2B15 demonstrated that UGT1A7, UGT1A9 and UGT1A10 catalysed the glucuronidation of 7-hydroxybenzo(alpha)pyrene, as well as other environmental carcinogens, such as 2-hydroxyamino-1-methyl-6-phenylimidazo-(4, 5-beta)-pyridine. (lookformedical.com)
  • Diazinon (IUPAC name: O,O-Diethyl O-[4-methyl-6-(propan-2-yl)pyrimidin-2-yl] phosphorothioate, INN - Dimpylate), a colorless to dark brown liquid, is a thiophosphoric acid ester developed in 1952 by Ciba-Geigy, a Swiss chemical company (later Novartis and then Syngenta). (chemchart.com)
  • Gamithromycin CAS number is 145435 72 9 the appearance of white or off white crystalline powder odorless bitter slightly hygroscopic very soluble in chloroform soluble in methanol dilute hydrochloric acid It is dissolved in ethanol slightly soluble in acetonitrile and almost insoluble in water Gamithromycin is a 15. (volsenchem.com)
  • In the case of BILN-2061, the L-proline is 4-substituted with a quinoline ether, whereas VX-950 has a carboyclic ring fused to the L-proline ring. (allindianpatents.com)
  • Bis(chloroethyl) ether is a chemical compound (an ether), which contains two 2-chloroethyl groups. (chemchart.com)
  • The process of 4 6 DICHLORO 5 NITRO 2 PROPYLTHIOPYRIMIDINE CAS 145783 14 8 1 Add 700g of 4 6 dihydroxy 2 mercaptopyrimidine to 10kg of water add 5kg of 10 sodium hydroxide solution with stirring control temperature 25 C add 5kg of methanol 1 19kg of 1 brom after adding Propane stir the reaction at 40 45 C overnight. (volsenchem.com)
  • The ticagrelor intermediate 4 6 Dichloro 2 propylthio pyrimidine 5 amine CAS number 145783 15 9 his synthesis process is below 1 Add 4 6 dihydroxy 2 mercaptopyrimidine to water and add 10 NaOH and bromopropane in methanol at a temperature of 20 30 then raise the temperature to 30 40 and adjust the temperature for 11. (volsenchem.com)
  • Activation of protein kinase C by 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-py rid ine carboxylic acid methyl ester (Bay K 8644), a calcium channel agonist, in alveolar type II cells. (hellobio.com)
  • New compounds such as the HERG channel activator (3 R ,4 R )-4-[3-(6-methoxy-quinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid (RPR260243) will enable us to increase our understanding in cation channel modulation and to test the concept of channel activation as a clinically relevant principle in treatment of channelopathies. (aspetjournals.org)
  • Perfluorooctanoic acid (PFOA) (conjugate base perfluorooctanoate), also known as C8, is a synthetic perfluorinated carboxylic acid and fluorosurfactant. (chemchart.com)
  • However, Bay K 8644 (1 μM) increased resting tension by 23 ± 4.8% in young arteries and 4.7 ± 1.6% in old arteries. (frontiersin.org)
  • 2. The recording of ist was infrequent, was observed only in spontaneously beating SA node cells, and was facilitated by adding Bay-K 8644 to the pipette solution. (biomedsearch.com)
  • Our company is mainly engaged in R&D,contract manufacture and scale-up production of API,Advance Intermediates,Fine Chemicals,Bio Chemicals,Protect Amino Acids,Chiral compounds and Electronic Chemicals. (chembuyersguide.com)
  • Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. (lookformedical.com)
  • Pyrrole 2 carbonitrile CAS 4513 94 4 molecular formulaC5H4N2 molecular weight 92 1 density is 1 086 g cm3 appearance is fresh yellow to orange liquid Thera Category Organic compound Cas No 4513 94 4 Synonyms 2 Cyanopyrrole 99 2 Cyano 1H pyrrole Pyrrole 2 carbonitrile 98 Pyrrole 2 carbonitrile 98 1GR Pyrrole 2. (volsenchem.com)
  • Spontaneous [Ca(2+)](i) increases were abolished by an IP3 receptor antagonist, whilst the protein kinase C (PKC) inhibitor chelerythrine chloride prolonged their duration, indicating a role for PKC and inositol 1,4,5,-triphosphate receptor activation. (nih.gov)
  • Noradrenaline (10 microM) exhibited different actions on the various HVA current components: (1) it prolonged the activation kinetics of omega-CgTx-sensitive currents, (2) it depressed by about 20% the size of DHP-sensitive currents, and (3) it had little or no effects on the residual DHP- and omega-CgTx-resistant current although intracellularly applied guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) prolonged its activation time course. (nih.gov)
  • R 1 ) n is the same or different halogen atom, a (1-4C)alkyl-, or a (1-4C)alkoxy-group, and n=0. (freepatentsonline.com)