3-Oxoacyl-(Acyl-Carrier-Protein) Synthase: An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 2.3.1.41.Acyl Carrier Protein: Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.Transferases (Other Substituted Phosphate Groups): A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.Pantetheine: An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Fatty Acid Synthases: Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.Acyltransferases: Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Fatty Acid Synthase, Type II: The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.ThiophenesPolyketide Synthases: Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Acyl-Carrier Protein S-Malonyltransferase: This enzyme catalyzes the transacylation of malonate from MALONYL CoA to activated holo-ACP, to generate malonyl-(acyl-carrier protein), which is an elongation substrate in FATTY ACIDS biosynthesis. It is an essential enzyme in the biosynthesis of FATTY ACIDS in all BACTERIA.3-Oxoacyl-(Acyl-Carrier-Protein) Reductase: A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Bacterial Proteins: Proteins found in any species of bacterium.Coenzyme ACrystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Pantothenic Acid: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Genetic Complementation Test: A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.Enoyl-(Acyl-Carrier-Protein) Reductase (NADH): An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.Carbon-Sulfur Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Acylation: The addition of an organic acid radical into a molecule.Thiolester HydrolasesMalonyl Coenzyme A: A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.Isoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Triclosan: A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Saccharopolyspora: A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.Apoproteins: The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).Acyl Coenzyme A: S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.Multienzyme Complexes: Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.Anthraquinones: Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.Coriandrum: A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.Acyl-Carrier Protein S-Acetyltransferase: A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to form COENZYME A and acetyl-acyl-carrier protein.MalonatesKinetics: The rate dynamics in chemical or physical systems.Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Lipid A: Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.Acetyl Coenzyme A: Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.Peptide Synthases: Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.Naphthacenes: Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Plants: Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
*  Beta-ketoacyl-ACP synthase
... acyl-carrier-protein) synthase III (FabH)". Biotechnology and Bioengineering. 112 (8): 1613-1622. doi:10.1002/bit.25583. ISSN ... acyl-carrier-protein) synthase III (FabH)". Biotechnology and Bioengineering. 112 (8): 1613-22. doi:10.1002/bit.25583. PMID ... and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". Journal of Biological ... "Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of ...
*  Beta-ketoacyl-acyl-carrier-protein synthase II
... acyl-carrier-protein] Thus, the two substrates of this enzyme are (Z)-hexadec-11-enoyl-[acyl-carrier-protein] and malonyl-[acyl ... The systematic name of this enzyme class is (Z)-hexadec-11-enoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-pr otein] C- ... acyl-carrier-protein], CO2, and acyl-carrier-protein. This enzyme belongs to the family of transferases, specifically those ... acyl-carrier-protein] + malonyl-[acyl-carrier-protein] ⇌ {\displaystyle \rightleftharpoons } (Z)-3-oxooctadec-13-enoyl-[acyl- ...
*  List of MeSH codes (D08)
... acyl-carrier-protein) synthase MeSH D08.811.913.050.625 --- phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050. ... acyl-carrier-protein) reductase (nadh) MeSH D08.811.682.660.390 --- enoyl-(acyl-carrier protein) reductase (nadph, b-specific) ... acyl-carrier protein s-acetyltransferase MeSH D08.811.913.050.134.060 --- acetyl-CoA C-acetyltransferase MeSH D08.811.913.050. ... acyl-carrier protein s-malonyltransferase MeSH D08.811.913.050.173 --- 1-acylglycerol-3-phosphate O-acyltransferase MeSH ...
*  Beta-ketoacyl-acyl-carrier-protein synthase I
... acyl-carrier-protein Thus, the two substrates of this enzyme are acyl-acyl-carrier-protein and malonyl-acyl-carrier-protein, ... acyl-malonyl(acyl-carrier-protein)-condensing enzyme, acyl-malonyl acyl carrier protein-condensing enzyme, beta-ketoacyl acyl ... The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase ( ... beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-[acyl carrier protein] synthase, beta-ketoacylsynthase, condensing ...
*  List of EC numbers (EC 2)
... acyl-carrier-protein) synthase II EC 2.3.1.180: beta-ketoacyl-(acyl-carrier-protein) synthase III EC 2.3.1.181: lipoyl(octanoyl ... acyl-carrier-protein) S-acetyltransferase EC 2.3.1.39: (acyl-carrier-protein) S-malonyltransferase EC 2.3.1.40: acyl-(acyl- ... acyl-carrier protein) synthase EC 2.7.7.67: CDP-archaeol synthase EC 2.7.7.68: 2-phospho-L-lactate guanylyltransferase EC 2.7. ... acyl-carrier-protein) synthase EC 2.3.1.208: 4-hydroxycoumarin synthase EC 2.3.1.209: dTDP-4-amino-4,6-dideoxy-D-glucose ...
*  Thiolase
Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO (March 2001). "Inhibition of beta-ketoacyl-acyl carrier protein synthases ... Middleton B (April 1973). "The oxoacyl-coenzyme A thiolases of animal tissues". Biochem. J. 132 (4): 717-30. PMC 1177647 . PMID ... Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to ... or acyl carrier protein (ACP). All thiolases, whether they are biosynthetic or degradative in vivo, preferentially catalyze the ...
*  List of EC numbers (EC 1)
... acyl-carrier-protein) reductase (NADH) EC 1.3.1.10: enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) EC 1.3.1.11: 2- ... pyruvate synthase EC 1.2.7.2: 2-oxobutyrate synthase EC 1.2.7.3: 2-oxoglutarate synthase EC 1.2.7.4: carbon-monoxide ... acyl-(acyl-carrier-protein) desaturase EC 1.14.19.3: linoleoyl-CoA desaturase EC 1.14.19.4: Delta8-fatty-acid desaturase EC ... long-chain acyl-(acyl-carrier-protein) reductase EC 1.2.1.81: sulfoacetaldehyde dehydrogenase (acylating) EC 1.2.1.82: beta-apo ...
*  Ketoacyl synthase
The reaction proceeds as such: acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] → a 3-oxoacyl-[acyl-carrier ... acyl-carrier protein] + CO2 + [acyl-carrier protein In Streptococcus pneumonia, for example, synthase II is used as an ... The reaction proceeds as such: (Z)-hexadec-11-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] → (Z)-3-oxooctadec- ... "BRENDA - Information on EC 2.3.1.41 - beta-ketoacyl-[acyl-carrier-protein] synthase I". www.brenda-enzymes.org. Retrieved 2016- ...
1OX0: The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae.
In molecular biology, Beta-ketoacyl-ACP synthase EC 2.3.1.41, is an enzyme involved in fatty acid synthesis. It results in the formation of acetoacetyl ACP. Beta-ketoacyl-ACP synthase is a highly conserved enzyme that is found in almost all life on earth as a domain in fatty acid synthase (FAS). FAS has two types, aptly named type I and II. Type I is found in animals, fungi, and "lower eukaryotes." Type II is found in prokaryotes, plastids, and mitochondria. Beta-ketoacyl-ACP synthase III, perhaps the most well known of this family of enzymes, catalyzes a Claisen condensation between acetyl CoA and malonyl ACP. The image below reveals how CoA fits in the active site as a substrate of synthase III. Beta-ketoacyl-ACP synthases I and II only catalyze acyl-ACP reactions with malonyl ACP. Synthases I and II are ...
1E5M: The Crystal Structure of Beta-Ketoacyl-Acyl Carrier Protein Synthase II from Synechocystis Sp. At 1.54 A Resolution and its Relationship to Other Condensing Enzymes
The assignment of Cys163 as the active site cysteine is based on several lines of evidence. In a sequence comparison of 42 condensing enzymes of fatty acid and polyketide synthesis, Siggaard‐Andersen (1993) identified one conserved cysteine residue, which in KAS II corresponds to Cys163. In addition, this cysteine residue superimposes with the active site cysteine in thiolase I, Cys125. Covalent modification studies of β‐ketoacyl synthases (Kauppinen et al., 1988; Funabashi et al., 1989) and thiolases (Izbicka‐Dimitrijevio et al., 1982) as well as mutagenesis of this residue in the β‐ketoacyl synthase domain of rat fatty acid synthase (Joshi et al., 1997) and thiolase from Zooglea ramigera (Thompson et al., 1989) support the proposed role of this cysteine as the nucleophile in the catalytic reaction.. At the entrance of the active site pocket, a bulky conserved residue, Phe400, is located. This residue points into the active ...
ID FABF_ECOLI Reviewed; 413 AA. AC P0AAI5; P39435; DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 25-OCT-2017, entry version 109. DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 2; DE EC=2.3.1.179; DE AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase II; DE AltName: Full=Beta-ketoacyl-ACP synthase II; DE Short=KAS II; GN Name=fabF; Synonyms=fabJ; OrderedLocusNames=b1095, JW1081; OS Escherichia coli (strain K12). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-32. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=7972002; ...
Paenibacillus polymyxa is a common soil bacterium with broad range of practical applications. An important group of secondary metabolites in P polymyxa are non-ribosomal peptide and polyketide derived metabolites (NRPs/PKs). Modular non-ribosomal peptide synthetases catalyze main steps in the biosynthesis of the complex secondary metabolites. Here we report on the inactivation of an A26 Sfp-type 4-phosphopantetheinyl transferase (Sfp-type PPTase). The inactivation of the gene resulted in loss of NRPs/PKs production. In contrast to the former Bacillus spp. model the mutant strain compared to wild type showed greatly enhanced biofilm formation ability. A26 Delta sfp biofilm promotion is directly mediated by NRPs/PKs, as exogenous addition of the wild type metabolite extracts restores its biofilm formation level. Wheat inoculation with bacteria that had lost their Sfp-type PPTase gene resulted in two times higher plant survival and about three times increased biomass under severe drought stress ...
By this invention, compositions and methods of use of Ricinus communis cDNAs encoding β-ketoacyl-ACP synthase, are provided. Also of interest are plants, plant parts and plant cells comprising the nucleic acid sequences.
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
BioAssay record AID 540353 submitted by NCGC: qHTS for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Followup in B. Subtilis HM489.
Structure-based Analysis of the Molecular Interactions between Acyltransferase and Acyl Carrier Protein in Vicenistatin BiosynthesisStructure-based Analysis of the Molecular Interactions between Acyltransferase and Acyl Carrier Protein in Vicenistatin Biosynthesis ...
BioAssay record AID 2701 submitted by NCGC: Confirmation qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase).
Shop Granaticin polyketide putative beta-ketoacyl synthase ELISA Kit, Recombinant Protein and Granaticin polyketide putative beta-ketoacyl synthase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Acyl carrier protein (ACP) is essential for the synthesis of fatty acids, phospholipids, lipid A and other primary and secondary metabolites. ACP and ACP-like proteins are found throughout nature; however, differences between prokaryotic and eukaryotic ACP makes bacterial ACP-dependent enzymes attractive antibacterial targets. In the 50 years since its initial discovery, the structures of many bacterial ACPs (including that of Vibrio harveyi, the focus of this work) have been determined: all sharing a dynamic four α-helix bundle structure with a hydrophobic binding pocket enclosing attached fatty acyl chains. It has been hypothesized that ACP must undergo a conformational change to expose the sequestered acyl chain to a partner enzyme; the mechanism of and residues important to this conformational change remain unknown. Towards this end, I have explored the effect of constraining ACPs termini on its ...
Background - There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains. Herein, we have examined the susceptibility of mycobacteria to the natural product platensimycin.. Methods and Findings - We have demonstrated that platensimycin has bacteriostatic activity against the fast growing Mycobacterium smegmatis (MIC = 14 µg/ml) and against Mycobacterium tuberculosis (MIC = 12 µg/ml). Growth in the presence of paltensimycin specifically inhibited the biosynthesis of mycolic acids suggesting that the antibiotic targeted the components of the mycolate biosynthesis complex. Given the inhibitory activity of platensimycin against β-ketoacyl-ACP synthases from Staphylococcus aureus, M. tuberculosis KasA, KasB or FabH were overexpressed in M. smegmatis to establish whether these mycobacterial KAS enzymes were ...
B-Specific) Enoyl-(Acyl-Carrier Protein) Reductase (NADPH: An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. It has a preference for acyl derivatives with carbon chain length from 4 to 16.
BioAssay record AID 406450 submitted by ChEMBL: Inhibition of Plasmodium falciparum FabI assessed as saturated acyl-acyl carrier protein level at 5 uM by MALDI-TOF mass spectrometry.
Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesis. We have determined its crystal structure at 3.2 angstrom resolution covering five catalytic domains, whereas the flexibly tethered terminal acyl carrier protein and thioesterase domains remain unresolved. The structure reveals a complex architecture of alternating linkers and enzymatic domains. Substrate shuttling is facilitated by flexible tethering of the acyl carrier protein domain and by the limited contact between the condensing and modifying portions of the multienzyme, which are mainly connected by linkers rather than direct interaction. The structure identifies two additional nonenzymatic domains: (i) a pseudo-ketoreductase and (ii) a peripheral pseudo-methyltransferase that is probably a remnant of an ancestral methyltransferase domain maintained in some related polyketide ...
Rhodococcus erythropolis fabD, acpM, kasA/B, accD6 genes for probable malonyl CoA-acyl carrier protein transacylase, probable acyl carrier protein, probable beta-ketoacyl-acp synthase, probable acetyl/propinoyl-CoA carboxylase, partial and complete ...
ID PROAS_1_PE1015 STANDARD; PRT; 332 AA. AC PROAS_1_PE1015; D4HDE3; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3; EC=2.3.1 DE 180;AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III;AltName: DE Full=Beta-ketoacyl-ACP synthase III; (PROAS_1.PE1015). GN Name=fabH; OrderedLocusNames=HMPREF0675_4043; OS PROPIONIBACTERIUM ACNES SK137. OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Propionibacterineae; Propionibacteriaceae; Propionibacterium. OX NCBI_TaxID=553199; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PROAS_1.PE1015. CC Propionibacterium acnes SK137 chromosome, ...
Accepted name: oleoyl-[acyl-carrier-protein] hydrolase. Reaction: an oleoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + oleate. Other name(s): acyl-[acyl-carrier-protein] hydrolase; acyl-ACP-hydrolase; acyl-acyl carrier protein hydrolase; oleoyl-ACP thioesterase; oleoyl-acyl carrier protein thioesterase. Systematic name: oleoyl-[acyl-carrier protein] hydrolase. Comments: Acts on acyl-carrier-protein thioesters of fatty acids from C12 to C18, but the derivative of oleic acid is hydrolysed much more rapidly than any other compound tested.. Links ...
Ketoacyl synthases (KSs) catalyze the condensation reaction of acyl-CoA or acyl-acyl ACP with malonyl-CoA to form 3-ketoacyl-CoA or with malonyl-ACP to form 3-ketoacyl-ACP. This reaction is a key step in the fatty acid synthesis cycle, as the resulting acyl chain is two carbon atoms longer than before. KSs exist as individual enzymes, as they do in type II fatty acid synthesis and type II polyketide synthesis, or as domains in large multidomain enzymes, such as type I fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs are divided into five families: KS1, KS2, KS3, KS4, and KS5. Fatty acid synthase (FAS) is the enzyme system involved in de novo fatty acid synthesis. FAS is an iterative multienzyme consisting of several component enzymes, one of which is ketoacyl synthase. There ...
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Mammalian FAS consists of a homodimer of two identical protein subunits, in which three catalytic domains in the N-terminal section (-ketoacyl synthase (KS), malonyl/acetyltransferase (MAT), and dehydrase (DH)), are separated by a core region of 600 residues from four C-terminal domains (enoyl reductase (ER), -ketoacyl reductase (KR), acyl carrier protein (ACP) and thioesterase (TE)).[16][17] The conventional model for organization of FAS (see the head-to-tail model on the right) is largely based on the observations that the bifunctional reagent 1,3-dibromopropanone (DBP) is able to crosslink the active site cysteine thiol of the KS domain in one FAS monomer with the phosphopantetheine prosthetic group of the ACP domain in the other monomer.[18][19] Complementation analysis of FAS dimers carrying different mutations on each monomer has established that the KS and MAT domains can cooperate ...
The citrate lyase activation starts with a 3-dephospho-CoA reacting with ATP and a hydrogen ion through a triphosphoribosyl-dephospho-CoA synthase resulting in a adenine and a 2-(5-triphospho-alpha-D-ribosyl)-3-dephospho-CoA. The latter compound in turn reacts with with a citrate lyase acyl-carrier protein through a apo-citrate lyase phosphoribosyl-dephospho-CoA transferase resulting in the release of a pyrophosphate and a hydrogen ion and a holo citrate lyase acyl-carrier protein.This protein complex can either react with a hydrogen ion and a acetate resulting in the release of a water and an acetyl-holo citrate lyase acyl-carrier protein. The holo acyl-carrier protein creacts with an ATP and an acetate through a citrate lyase synthase resulting in the ...
Looking for online definition of Carrier proteins in the Medical Dictionary? Carrier proteins explanation free. What is Carrier proteins? Meaning of Carrier proteins medical term. What does Carrier proteins mean?
forms trimers with three closely packed beta-sheets; possible link between the YjgF-like (d.79.1) and 4-phosphopantetheinyl transferase superfamilies (d.150.1) ...
In this study, we show a novel and essential role of SMS2 in modulating NFκB activation. This is based on the following observations: in both SMS2 KO mouse macrophages and SMS2 knockdown HEK293 cells, (1) SMS activity, de novo SM synthesis, cellular and plasma membrane SM levels were significantly decreased, (2) ligand-induced NFκB activation, including IκBα degradation and NFκB nuclear translocation, as well as transcriptional activation, were significantly attenuated, and (3) LPS-induced membrane recruitment of TLR4-MD2 complex and TNF-α-induced raft association of TNFR1 were impaired in SMS2 KO macrophages and SMS2 siRNA-treated HEK293 cells, respectively.. SMS2 makes an important contribution to the de novo SM biosynthesis and total cellular SM levels. Based on their relative proximity to the site of ceramide biosynthesis, it has been suggested that SMS1 might be involved in the de novo SM biosynthesis whereas SMS2 is involved in the remodeling of plasma membrane structure.28 However, ...
Modak R, Sinha S and Surolia N, Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein. Role of the 4-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein. , FEBS Journal 274, 3313 - 3326 (2009 ...
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Acyl carrier protein (ACP) is a small (9 kD) acidic protein that is an essential cofactor in plant fatty acid biosynthesis. Most plants have several isoforms of ACP, some of which are expressed constitutively and others that appear to be more tissue
Rhodococcus erythropolis fabD, acpM, kasA/B, accD6 genes for probable malonyl CoA-acyl carrier protein transacylase, probable acyl carrier protein, probable beta-ketoacyl-acp synthase, probable acetyl/propinoyl-CoA carboxylase, partial and complete ...
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2LTE: Solution NMR structure of the specialized acyl carrier protein PA3334 (apo) from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium Target PaT415.
Author Summary Vaccinia virus, the prototypic poxvirus, is closely related to variola virus, the etiological agent of smallpox. A full understanding of the poxviral life cycle is imperative for the development of novel antiviral therapies, the design of new vaccines, and the effective and safe use of these viruses as oncolytic agents. Metabolomic studies have shed light on the novel mechanisms used by viruses to replicate efficiently within their hosts. de novo fatty acid biosynthesis has been shown to be of relevance for numerous viral infections as well as for the development of cancer. Here we describe an important role for de novo fatty acid biosynthesis during vaccinia infection. Ongoing synthesis of palmitate is needed to fuel the production of energy within mitochondria. The biochemical events of viral DNA replication and protein synthesis are minimally affected by inhibition of this pathway, but viral assembly is disrupted more dramatically. Further exploration of this pathway will ...
Methane utilization by methanotrophic bacteria is an attractive application for biotechnological conversion of natural or biogas into high-added-value products. Haloalcaliphilic methanotrophic bacteria belonging to the genus Methylomicrobium are among the most promising strains for methane based biotechnology, providing easy and inexpensive cultivation, rapid growth, and the availability of established genetic tools. A number of methane bioconversions using these microbial cultures have been discussed, including the derivation of biodiesel, alkanes, and OMEGA-3 supplements. These compounds are derived from bacterial fatty acid pools. Here, we investigate fatty acid biosynthesis in Methylomicrobium buryatense 5G(B1). Most of the genes homologous to typical Type II fatty acid biosynthesis pathways could be annotated by bioinformatics analyses, with the exception of fatty acid transport and regulatory elements. Different approaches for improving fatty acid accumulation were investigated. These ...
Accepted name: trans-2-decenoyl-[acyl-carrier protein] isomerase. Reaction: a trans-dec-2-enoyl-[acyl-carrier protein] = a cis-dec-3-enoyl-[acyl-carrier protein]. Other name(s): β-hydroxydecanoyl thioester dehydrase; trans-2-cis-3-decenoyl-ACP isomerase; trans-2,cis-3-decenoyl-ACP isomerase; trans-2-decenoyl-ACP isomerase; FabM. Systematic name: decenoyl-[acyl-carrier protein] Δ2-trans-Δ3-cis-isomerase. Comments: While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and ...
The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones.
Rhodococcus erythropolis fabD, acpM, kasA/B, accD6 genes for probable malonyl CoA-acyl carrier protein transacylase, probable acyl carrier protein, probable beta-ketoacyl-acp synthase, probable acetyl/propinoyl-CoA carboxylase, partial and complete ...
A 75 kb gene cluster in Pseudomonasfl uorescens NCIMB 10586 encodesa modular polyketide synthase responsible for biosynthesis of the antibiotic mupirocin. All seven PKS modules lack intrinsic acyl transferase (AT) domains. Two AT domains within the multifunctional polypeptide MmpC are thought to operate in trans. An unusually large tailoring region encodes 26 discrete proteins that modify the polyketide/fatty acid backbone, in addition to providing resistance and regulatory functions. This study investigated the functions of four tailoring region genes. MupJ, MupK and mAcpC were revealed to be involved in insertion of a β-methyl group, while MupN was shown to have phosphopantetheinyl transferase activity. Five tailoring acyl carrier proteins (mAcps) were found to be specific and non-interchangeable, and the influence of C-termini on mAcp-specificity was investigated. Attempts to overexpress mAcps in P. ...
Tuberculosis continues to be a major cause of morbidity and mortality all over the world. No new drug has been developed in the past 30 yr. Consequently, there is an urgent need to identify new drug targets in mycobacteria and eventually, develop new drugs. The enoyl acyl carrier protein reductase (ENR) from Mycobacterium tuberculosis is one of the key enzymes involved in the type II fatty acid biosynthesis pathway of M. tuberculosis. A series of pyrazoles linked with imidazoles were computationally designed and energy minimized. These ligands were investigated for drug like properties by calculating Lipinskis rule of five using molinspiration. These compounds were docked into the active site of ENR (PDB code, 2H7I) using Argus lab docking software which showed good affinity for the enzyme, when compared with the binging energies of standard drug isoniazid (-8.39kcal/mol.) Among all the designed ligands, the ligand 4 showed more binding energy values ...
A large body of evidence indicates that major affective disorders are accompanied by activated neuro-immune, neuro-oxidative and neuro-nitrosative stress (IO&NS) pathways. Postpartum depression is predicted by end of term prenatal depressive symptoms whilst a lifetime history of mood disorders appears to increase the risk for both prenatal and postpartum depression. This review provides a critical appraisal of available evidence linking IO&NS pathways to prenatal and postpartum depression. The electronic databases Google Scholar, PubMed and Scopus were sources for this narrative review focusing on keywords, including perinatal depression, (auto)immune, inflammation, oxidative, nitric oxide, nitrosative, tryptophan catabolites (TRYCATs), kynurenine, leaky gut and microbiome ...
9305965] Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. (Biochemistry. , 1997 ...
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Trypanosomes have an abundant GPI-anchored protein named variant surface glycoprotein. This GPI anchor is unusual in that it contains the fatty acid myristate. In studies on the origin of myristate, we discovered a robust fatty acid synthesis system whose major product is myristate (even though it was thought for 30 years that these parasites cannot make any fatty acid). In an investigation of the machinery for fatty acid synthesis we discovered a novel and unprecedented mechanism. Instead of using a conventional type I or type II synthase, found in all other cells, trypanosomes use microsomal elongases to make fatty acids de novo. They also have a type II fatty acid synthase in the mitochondria ...
Malonyl-CoA:acyl-carrier protein transacylase (MCAT), encoded by the fabd gene, is a key enzyme in type II fatty-acid biosynthesis. It is responsible for transferring the malonyl group from malonyl-CoA to the holo acyl-carrier protein (ACP). Since the type II system differs from the type I system that mammals use, it has received enormous attention as a possible antibiotic target. In particular, only a single isoform of MCAT has been reported and a continuous coupled enzyme assay has been developed. MCAT from Staphylococcus aureus was overexpressed in Escherichia coli and the protein was purified and crystallized. Diffraction data were collected to 1.2 A ° resolution. The crystals belonged to space group P21, with unit-cell parameters a = 41.608, b = 86.717, c = 43.163 A ° , α = γ = 90, β = 106.330 °. The asymmetric unit contains one SaMCAT molecule ...
Catalyzes the NAD-dependent reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Catalyzes the last reduction step in the de novo synthesis cycle of fatty acids. Involved in the elongation cycle of fatty acids which are used in lipid metabolism. Required for normal plant growth (By similarity).
The synthesis of lipids and acyl thioesters was studied in microsomal preparations from germinating pea (Pisum sativum cv. Feltham First) seeds. Under conditions of maximal synthesis (in the presence of exogenous acyl-carrier protein) acyl-acyl-carrier proteins accounted for about half the total incorporation from [14C]malonyl-CoA. Decreasing the concentrations of exogenous acyl-carrier protein lowered the overall synthesis of fatty acids by decreasing, almost exclusively, the radioactivity associated with acyl-acyl-carrier proteins. A time-course experiment showed that acyl-acyl-carrier proteins accumulated most of the radioactive label at the beginning of the incubation but, eventually, ...
To clarify the phylogenetic relationships of Carthamus species, we performed sequence analysis of the nuclear stearoyl acyl carrier protein desaturase (SACPD) gene and the chloroplast intergenic spacer region between leucine and phenylalanine tRNA genes (trnL-trnF IGS) in 13 taxa of Carthamus. The previous division of the genus into 4 taxonomic sections and allocation of particular genomes to various taxa on the basis of morphological, cytogenetic, and biosystematic analyses is not supported by the present study. Our results provide evidence of the occurrence of 5 nuclear genomes (A, B, C, X, and Y) and 3 cytoplasm types (A, B, and C) in the genus Carthamus. The cultivated safflower, C. tinctorius (2n = 24), has the B genome and type B cytoplasm. Both of these are not present in the polyploid taxa. This contradicts the earlier view that one of the genomes involved in the origin of the polyploid taxa of Carthamus is the B genome. Comparison with an outgroup ...
The mitochondrial acyl-carrier protein (ACP) functions in the synthesis of fatty acids within the mitochondrial matrix. Fatty acids are elongated on the covalently bound 4-phosphopantetheine cofactor on ACP. ACP has a second essential function within the mitochondria in the biogenesis of iron-sulfur clusters. Cells depleted of ACP are impaired in FeS cluster formation throughout the cell. ACP is a stable subunit of the cysteine desulfurase (Nfs1) and Isd11 subcomplex that generates sulfide ions for FeS cluster formation. The FeS defect observed in cells depleted of ACP can be partially suppressed by overexpression of the mitochondrial iron transporter Mrs3. The stability of ACP is dependent of the iron status of mitochondria. Thus, the central role of Acp1 in mitochondrial fatty acid synthesis, lipoic acid formation and FeS cluster biogenesis suggests that these processes are tied to Fe availability within the mitochondria. ...
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
D-amino acid malonyltransferase (Science: enzyme) From mung beans registry number: EC 2.3.1.- Synonym: 1-aminocyclopropanecarboxylate malonyltransferase, d-acc-malonyltransferase, acc n-malonyltransferase ...
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Inhibitors of 4-phosphopantetheine adenylyltransferase (PPAT) were identified through high-throughput screening of the AstraZeneca compound library. One series, cycloalkyl pyrimidines, showed inhibition of PPAT isozymes from several species, with the most potent inhibition of enzymes from Gram-positive species. Mode-of-inhibition studies with Streptococcus pneumoniae and Staphylococcus aureus PPAT demonstrated representatives of this series to be reversible inhibitors competitive with phosphopantetheine and uncompetitive with ATP, binding to the enzyme-ATP complex. The potency of this series was optimized using structure-based design, and inhibition of cell growth of Gram-positive species was achieved. Mode-of-action studies, using generation of resistant mutants with targeted sequencing as well as constructs that overexpress PPAT, demonstrated that growth suppression was due to inhibition of PPAT. An effect on bacterial burden was demonstrated in mouse lung and thigh infection models, but further
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health. Reduction in the expression of mitochondrial malonyl CoA-acyl carrier protein transacylase, a key enzyme in the pathway encoded by the nuclear Mcat gene, was achieved to varying extents in all examined tissues employing tamoxifen-inducible Cre-lox technology. Although affected mice consumed more food than control animals, they failed to gain weight, were less physically active, suffered from loss of white adipose tissue, reduced muscle strength, kyphosis, alopecia, hypothermia and shortened lifespan. The Mcat-deficient phenotype is attributed primarily to reduced synthesis, in several tissues, of the octanoyl precursors required for the posttranslational lipoylation of pyruvate and a-ketoglutarate dehydrogenase complexes, resulting in diminished capacity of the citric ...
TABLE-US-00022 TABLE 23 Pfam domain Accession Gathering name number cutoff Domain description 14-3-3 PF00244.9 25 14-3-3 protein 2OG-FeII_Oxy PF03171.10 11.5 2OG-Fe(II) oxygenase superfamily AAA PF00004.19 12.3 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.3 -5 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.4 4 ATPase family associated with various cellular activities (AAA) ABC2_membrane PF01061.13 -17.9 ABC-2 type transporter ABC_tran PF00005.16 9.5 ABC transporter ACP_syn_III_C PF08541.1 -24.4 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ADH_N PF08240.2 -14.5 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.16 23.8 Zinc-binding dehydrogenase AOX PF01786.8 25 Alternative oxidase AP2 PF00847.10 0 AP2 domain AT_hook PF02178.8 3.6 AT hook motif Aa_trans PF01490.7 -128.4 Transmembrane amino acid ...
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
Erythromycin A (1) is a macrolide antibiotic produced by the soil bacterium, Saccharopolyspora erythraea. It has been shown that erythromycin is biosynthesised from the sequential condensation of one propionyl and six methylmalonyl units on the polyketide synthase (PKS), to give the first enzyme free intermediate, 6-deoxyerythronolide B(2). The polyketide synthase consists of three large multifunctional proteins, DEBS 1, DEBS 2 and DEBS 3. 6-Deoxyerythronolide B (2) is then elaborated by a series of further tailoring enzymes, culminating with the production of erythromycin A (1). Three organisms capable of producing truncated erythromycin PKSs have been constructed; DEBS 1-TE, which contains a copy of the thioesterase from the end of DEBS 3 at the end of module 2, DEBS 2-TE, which contains a thioesterase at the end of module 4 and ΔDH DEBS 2-TE, another truncated PKS with the thioesterase at the end of DEBS 2, but with a non-functional dehydratase in module ...
Carbamyl-phosphate synthase II La carbamyl-phosphate synthase II est une ligase qui catalyse la réaction : 2 ATP + L-glutamine + HCO3- + H2O ⇌ {\displaystyle \rightleftharpoons } 2 ADP + phosphate + L-glutamate + carbamyl-phosphate. Le mécanisme réactionnel de cette enzyme se déroule en quatre étapes : L-glutamine + H2O ⇌ {\displaystyle \rightleftharpoons } L-glutamate + NH3 ATP + HCO3- ⇌ {\displaystyle \rightleftharpoons } ADP + carboxyphosphate NH3 + carboxyphosphate ⇌ {\displaystyle \rightleftharpoons } carbamate + phosphate ATP + carbamate ⇌ {\displaystyle \rightleftharpoons } ADP + carbamyl-phosphate Elle est activée par lATP et le PRPP et est inhibée par lUMP, produit final de la biosynthèse des nucléotides pyrimidiques. Contrairement à la plupart des enzymes ayant une activité carboxylase, la carbamyl-phosphate synthase II nutilise pas la biotine comme cofacteur. (en) Anderson, P.M. and Meister, A., « Evidence for an activated form of carbon dioxide ...
The major source of carbon to the bacterial community in a seagrass (Thalassia testudinum) dominated region of Lower Laguna Madre, Texas was determined with the isotopic composition of bacterial phospholipid fatty acids. Rough estimates of bacterial abundance were also obtained from total phospholipid fatty acid concentrations. Core samples came from three differing habitat types consisting of a bare area, a transitional area, and a vegetated area. Five depth intervals of 0-0.5 cm, 0.5-2.5 cm, 4.5-6.5 cm, 8.5-10.5 cm, and 18.5-20.5 cm from each core were used for analyses. Bacterial abundance was significantly higher in the vegetated habitat compared with bare or transitional habitats, which showed little difference from one another. The stable carbon isotope ratios ([ð]¹³C) of branched chain fatty acids, iso- and anteiso-15:0 (i&a15:0) found only in bacteria were used to assess carbon utilization. The [ð]¹³C of total organic carbon (TO¹³C) and the ubiquitous fatty acid 16:0 were used as ...
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
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Its only about a week kasi pinatingin namin sa doktor, mali yong ginawa namin dito [pointing to her lip]. Kasi minamadali nila ako para umapir sa TV. Nilagyan lang nila kasi ng glue kaya yong tissue at kinonek lang, so hindi ito ini-stich. So what happened now ay nagkaroon ng spare skin and its growing into a keloid. Its not good kasi lumalaki talaga siya and it will reach up to here [sa nose]," kuwento ng TV host-actress ...
Outer membrane (OM) proteins 5, 6, 7, 20, 22, 37, 40, and 70 are subunits of the TOM system that transports proteins across the outer membrane. Proteins 9, 10, 12, 22 and 54 are subunits of the TIM system that mediates import of multispanning carrier proteins into the inner membrane (IM). A carrier precursor exiting the TOM channel is captured by the 70 kDa Tim9/10-complex in the intermembrane space and transferred to the 300 kDa inner membrane complex that contains Tim9p, Tim10p, Tim12p, Tim22p and Tim54p. Binding to the Tim22-complex triggers the membrane potential dependent insertion of mulitspanning carrier into the inner membrane. Inner membrane proteins 11, 17, 23 and 44 are members of, or closely adjacent to, the second TIM system (Tim17-complex)that mediates transport of precursors carrying a targeting presequence ...
anga. 1. Ir Dvasia, ir su ad tin kvie ia: Ateik! Ir kas girdi, teatsiliepia: Ateik! Ir kas trok ta, teateina, ir kas nori, tesisemia dovanai gyvyb s vandens (Apr 22, 17). ie Aprei kimo knygos od iai skamba mano mintyse, kai prisimenu, kaip prie keturiasde imt met , tiksliau 1963 m. gruod io 4 d., mano garbingasis pirmtakas popie ius Paulius VI paskelb konstitucij apie vent j liturgij Sacrosanctum Concilium. I tikr j kas yra liturgija, jei ne sutartinis ventosios Dvasios ir Su ad tin s, ventosios Ba ny ios balsas, aukiantis Vie pa iui J zui: Ateik ? Kas kita yra liturgija, jei ne tas tyras ir am inas gyvojo vandens altinis, kuriame kiekvienas trok tantis gali laisvai gauti Dievo dovan (plg. Jn 4, 10)?. I tikr j konstitucijoje apie vent j liturgij , kuri buvo Vatikano II Susirinkimo, did iul s malon s, praturtinusios Ba ny i XX am iuje (1), pirmasis vaisius, ventoji Dvasia kalb jo Ba ny iai nepaliaujamai vesdama Vie paties mokinius tiesos pilnatv (Jn 16, 13). io vykio keturiasde imt j metini ...
am1a04d AJ229366 409 3.0 E-41 D-arabinitol dehydrogenase (EC 1.1.1-) C. albicans 3.4 E-41 D-arabinitol dehydrogenase (EC 1.1.1-) C. tropicalis 5.8 E-41 D-arabinitol dehydrogenase (EC 1.1.1-) P. stipitis am2f05d AJ229451 261 6.0 E-18 Putative agmatinase precursor (EC 3.5.3.11) S. pombe 2.0 E-08 Possible agmatinase (EC 3.5.3.11) S. clavuligerus 4.9 E-06 Hypothetical agmatase (EC 3.5.3.11) M. fervidus okam5d07r AJ229891 230 0.1 E-10 Beta-ketoacyl-ACP reductase (EC 1.1.1.100) C. lanceolata 0.2 E-10 Hypothetical protein 5 Xanthobacter sp 6.3 E-10 Hypothetical oxidoreductase B. subtilis am2d01d AJ229435 151 2.9 E-07 YOL5_CAEEL hypothetical 45.3 KD protein C. elegans okam1d10r AJ229574 268 0.2 E-06 Acetamidase (EC 3.5.1.4) A. nidulans ...
Buy fabZ recombinant protein, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase (fabZ) Recombinant Protein-YP_145081.1 (MBS1409712) product datasheet at MyBioSource, Recombinant Proteins
Control of small molecule hapten epitope densities on antigenic carrier proteins is essential for development and testing of optimal conditions for vaccines. Yet, accurate determination of epitope density can be extremely difficult to accomplish, especially with the use of small haptens, large molecular weight carrier proteins, and limited amounts of protein. Here we report a simple radiometric method that uses 14C-labeled cystine to measure hapten epitope densities during sulfhydryl conjugation of haptens to maleimide activated carrier proteins.
BioAssay record AID 90850 submitted by ChEMBL: In vitro inhibitory activity against Holo-[acyl-carrier-protein] synthase was determined using Bacillus subtilis GST-Acp-HTRFassay.
1-amino-2-ethylcyclopropane-1-carboxylic acid: an ethylcyclopropyl amino-acid derived from isoleucine; it may be coupled to coronafacic acid by coronafacate ligase to form coronatine; substrate of malonyltransferase & inhibitor of 1-aminocyclopropane-1-carboxylic acid malonyltransferase; RN given refers to cpd without isomeric designation
Good Day! :) just wanna ask if legit ba yung ishi premium sa lazada?i prefer kasi na COD, i purchased one before im not sure if authentic yun and di ko sya natuloy tuloy. im planning to take ishi again ok lang ba to take this kahit na nasa shifting sched ako? every 2 weeks nagchachange yung sched ko minsan morning minsan night, would that affect the effectiveness of ishi? and how long ko sya consistently dapat itake i actually have a fair skin na problem was lately nagkakabreakout ako still didnt know the cause kasi before hindi naman ako ganito. hope you could help me on this. Thanks in advance! :). ReplyDelete ...
Good Day! :) just wanna ask if legit ba yung ishi premium sa lazada?i prefer kasi na COD, i purchased one before im not sure if authentic yun and di ko sya natuloy tuloy. im planning to take ishi again ok lang ba to take this kahit na nasa shifting sched ako? every 2 weeks nagchachange yung sched ko minsan morning minsan night, would that affect the effectiveness of ishi? and how long ko sya consistently dapat itake i actually have a fair skin na problem was lately nagkakabreakout ako still didnt know the cause kasi before hindi naman ako ganito. hope you could help me on this. Thanks in advance! :). ReplyDelete ...
Look, I live in Green Meadows, I was a povedan, I used to attend these parties and got over it as soon as I stepped into 1st year college. Yang "open party" hype na yan, mawawala din. Believe me. Yung nakakainis pa is that yeah, parents do generalize, see just because taga-poveda ako before and taga-GM ako now, tingin na ng parents ng classmates ko, kasama kami sa nag-organize nun. Lets get things straight:. 1) Apparently, this party was organized by THIRD year HS Povedans. not 1st yr or 2nd yr girls who are allegedly part of THE GOOD FRAT.. 2) There were NO CONDOMS and or DRUGS. They drank though. Dun sila mali, but then again, who didnt? You see whn your kids turn 18, theyre usually legal to do everything theyve been doing since they were…i dunno…11? kaso magsasawa sila kasi legal na e, gusto lang nila yan kasi pinagbabawal... 3) MARCEL did touch the girl. Thats why he GOT it. See, if MARCEL pursued his malicious ways and people didnt do anything about it then we wouldnt be talking about ...
I have seen women with bigger thighs then jessy, I am telling you they can still cross their legs and walk wayyy better. It is about the attitude on how you present yourself or the product you are presenting. Sakanila kasi real or genuine confidence. Kay jessy kasi diko alam kung confident siya or cocky. Basta yung sakaniya is pangshow off, not confidence.. Delete ...
Last february 16, 2009. Habang gumagawa ng Individual Case Study for NCMH Duty I felt dizziness, weakening, muscle weakness and headache. Sumakit din ung throat ko pero still continue with my work. Akala ko kasi ung mga nararamdaman ko is psychological (signs and symptoms ng katamaran.. haha). The next day, February 17, 2009. Gumising ako ng 4am, super bigat talaga ng katawan ko. Ang sakit sakit ng ulo ko then I tried to checked my temperature, it was 38.9 °C! Gusto ko talaga pumasok kasi pasahan na ng case study pero sabi nila magpahinga ako, ayaw ako papasukin ng daddy ko. so ayun, hindi nga ako pumasok. natulog ako buong araw. Then pumunta ako sa MMC para sa magpacheck up. nakita ko pa ung kabilang section nagduduty (Group 2 section A group yan ng pinsan ko, nakita ko pa ung pinsan kong makulit hehe). Super nanghihina ako nung pumunta kami sa MMC nahihirapan nga ako maglakad. Anyway, nung nagpacheck up ako. Naiinis ako dun sa Doctor, di man lang chineck breath sounds ko, chineck ung tonsils ...
terus scan.... gambo takde doktor tk kasi... bile di scan, sikit lagi uri aku duk bawah, doktor kata type I ... alhamdulillah.. ahh lega sikit...tp belomm sepenohnye... kata doktor anak kedudukan dh oke.. tak melintang lg...kepala dah ke bawah.. sampai doktor nk memula scan kasi tolak kepala baby keatas skit... kata dokto anak dah memang ke bawah.. patut la aku rasa selalu sakit je kat bawah..anak selalu je duk tekan2... awal lagi la dik.... ...
Magandang buhay po sa inyong lahat...Unang una po ay nagpapaabot ako ng taos-pusong pasasalamat sa mga taong magkakaroon ng oras at panahong magbasa ng aking munting sulat para sa lahat....Ako po ay si ALEX Peñaredondo LAAD, 26 taong gulang, may asawa at dalawang maliliit na anak...Nais ko po sanang humingi ng kahit kaunting tulong sa kahit na anong paraan para po maoperahan sa PGH kasi hindi kayang operahan kahit saang ospital dito sa Bicol...nangangailangan po ako ng pera para may magamit papunta sa Manila upang doon magpa-opera...lumalapit po ako sa inyo sa paraang alam ko kasi gusto ko pa po mabuhay, gustong gusto ko pang makasama ng matagal ang aking pamilya... Ako po ay mayroong bukol sa loob ng bibig at lumabas sa ilong...ang tawag daw po dito ay NASOPHARYNGEAL MASS COMPATIBLE WITH ANGIOFIBROMA. Ito po ay base sa mga ginawang test sa akin noong Nobyembre ng nagdaang taon lamang....ang operasyon po ay kailangan gamitan ng EMBOLIZATION-babarahan ang mga ugat sa bukol. Nagkakahalaga ng ...
ang galing lang kasi ganito ako mag-isip.. tapos as in tanggap ko whatever is happening to me.. dati akala before my 1st brain surgery, kala nila na im just hiding my real emotion na nagtatapang-tapangan lang ako.. my mom & friends even ask a priest friend to talk to me pra ma-realease whatever im hiding.. pero wala tlga! ewan ko ba.. ok lang talaga sakin.. and syempre i thank God for that.. siguro nung holy week nung 2006 kaya ako mejop nag struggle emotionally kasi ive been too confident na anjan lng si God.. hindi na ko kumakatok sa kanya.. hay super talaga yung week na yun! parang nababaliw na ko.. ayun im always praying.. lagi akong may hawak na cross.. prang feeling ko pag binitawan ko yun eh bibitiw din ako.. parang naglalaban sain ang good n back.. prang yung mga sat.v. or pelikula or cartoons nagaaway ang angel n devil.. hehe. ganun ang feeling! nakakatawa! pero syempre nanalo ang good! as in after easter sunday OK na ko! i told my mom na from that day ill do what i can na.. basta ...
ZEL here! :)) Suggestions ko... if you really want a WHITER Skin na very Visible you can try ACTIVE WHITE Capsules,30 Caps. mabibili lang sa DrugStores or Prescribed ng Dermatologist niyo, dont Trusr Online buying ng Caps. kasi sometimes ay Fake ang laman, Mejo mahal nga lang nasa 1,000php up to 2k pero WOrth it naman kasi yun din naman ang nirerecommend ng mga Dermatologist sa ibang Artist natin para maganda sila sa TV. Active WHite has Grapeseed & Vitamin C that will help ur Skin looks younger & Whiter, it also cleanses ur body, inaalis kc niya yung Toxins ng katawan & the Liver filters it so ang effect ng Active White Glutathione is maging maputi ka, but make sure youll be Using Sunscreen Protection/Sun Block w/ SPF 15 upper or much better kung hindi kayo masyadong nagpapa-araw. I wont suggest you to use Injectables cause it may cause Skin Problems soon as maexpose kayo sa Araw or even Flourecent Light ay pwedeng makacause ng Darkening ng Balat, meaning nasusunog yung Skin mo dahil ...
ZEL here! :)) Suggestions ko... if you really want a WHITER Skin na very Visible you can try ACTIVE WHITE Capsules,30 Caps. mabibili lang sa DrugStores or Prescribed ng Dermatologist niyo, dont Trusr Online buying ng Caps. kasi sometimes ay Fake ang laman, Mejo mahal nga lang nasa 1,000php up to 2k pero WOrth it naman kasi yun din naman ang nirerecommend ng mga Dermatologist sa ibang Artist natin para maganda sila sa TV. Active WHite has Grapeseed & Vitamin C that will help ur Skin looks younger & Whiter, it also cleanses ur body, inaalis kc niya yung Toxins ng katawan & the Liver filters it so ang effect ng Active White Glutathione is maging maputi ka, but make sure youll be Using Sunscreen Protection/Sun Block w/ SPF 15 upper or much better kung hindi kayo masyadong nagpapa-araw. I wont suggest you to use Injectables cause it may cause Skin Problems soon as maexpose kayo sa Araw or even Flourecent Light ay pwedeng makacause ng Darkening ng Balat, meaning nasusunog yung Skin mo dahil ...
Mas mataba pa si DL sa personal, pero mas gwapo kesa sa picture. Ang problema, naging awkward ang kilos. Suddenly parang hindi nya ako kilala. Parang nawala ang elibs nya sa sarili na na-in love nga ako. Naramdaman ko yun kahit hindi nya sinabi. Hanggang mg mga biro na sya, birong totoo, na naghahatid ng mensaheng magpapakasal ako sa kanya kahit hindi ako in-love. Nasaktan ang puso ni Manang, kaya kahit type ko sana, yung naramdaman kong hindi lubos ang tiwala nya sa akin (at sa sarili nya dahil hindi sya makapaniwalang ang Pinay madaling ma-in love sa lalaking thoughtful), nagdalawang-isip ako. Natapos ang hk, tuloy ang aming komunikasyon, hanggang tinatanong na nya kung magfa-file na ba sya ng fiancee visa. Sabi ko hindi muna, kasi hindi pa ako sigurado kung love ko sya. Medyo love ko pa rin naman, pero nag-iisip na ako para sa mga anak ko. Si DL kasi, madalas din sabihin, dahil alam nyang gusto ko close to nature, malawak ang space, me privacy, eh sya city boy, nakatira sa apt, baka raw di ko ...
Isa pa ngang subok- yan ba ang movie nila? Napansin ko na din yan eh.. Sa twitter nilang 2 di sila naguusap o nagcoconnect which is unlikely kasi dapat kahit papano naging magkaclose sila habang shooting dahil sila lang naman 2 ang lead.. Samantalang before mga costars nila pareho nagiging close nila.. Tapos sa promo nila never sila nagsabay na 2 babae nagpainterview.. Once lang sa ang bus tapos parang di sila friends, na nakakataka why.. Eh mabiro naman sila pareho before sa costars.. At sa mga pics nila na lumabas at instagram parang sa mga party with the cast palaging wala silang pics magkasama or palaging wala yung nanghihiram ng asawa, yung legal na asawa ang kaclose ng mga direktor.. Kaya nalilito ako ngayon sino si FL1 at FL2 sa kanila.. Kasi if tolerable ng crew si FL2 eh palaging kasama ng crew sa pics si legal na asawa.. So bitch pala si FL1 na nanghihiram ng asawa? Eh sa personality magkabaligtad.. Hay ...
Pine bark extract acts to be a catalyst on the NO Synthase system, which permits vasodilation. Furthermore, it minimizes inflammation while in the arterial blood vessels and boosts their elasticity even though guarding the endothelial cells. Pine bark extract is hence in some cases referred to as a Nitric Oxide Booster ...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
A study reports that low blood protein levels are found to be associated with reduced insulin resistance and thus risk of diabetes, metabolic syndrome and cardiovascular disease decreased.
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Küsimus: Käisin kontrollis ja analüüsid näitasid ureaplasma olemasolu. Ravi pidime tegema koos partneriga. Kuna partner seda teha ei saanud, sain ravi ainult mina. Kas kondoom kaitseb sajaprotsendiliselt ureaplasma eest? Kust see ureaplasma tuleb? Kas ainult meespartnerilt või ka tema endistelt partneritelt? - DELFI
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Nöromiyotoni, sürekli kas lifi hareketinden kaynaklı kas gerginliğiyle kendini belli eden nöromüsküler bir hipereksitilabite bozukluğudur. Bu rahatsızlık, voltaja duyarlı, presinaptik potasyum kanallarına karşı gerek izolasyon gerekse paraneoplastik bir süreç görevi üstlenen yüksek antikor seviyesine sahip immün aracılı bir bozukluktur. Belirtileri arasında kasların rahatlama hareketi esnasında kas çekilmesi (miyokimi), kramplar, psödomiyotoni (kas gevşemesinde gecikme), aşırı terleme ve bazen de kas güçsüzlüğü sayılabilir. Bu olgu sunumnda, bir ay boyunca her iki uyluğunda ağrı tespit edilen yetmiş iki yaşında bir erkek hastayı incelemekteyiz. Buna göre hastalık, ayaklara ve göğüs bölgesini de içine alacak şekilde git gide kötüleşmiş durumdaydı. Çekilen beyin tomografisinde, beyin atrofisi olduğu ortaya çıkmıştı. EMG sonuçları, tipik Isaacs Sendromu belirtisi olan karakteristik dalga sıklığı ve genişliği tespitiyle ...
Ērces dzīvo trīs līdz piecus gadus. Tās vairojas dzimumvairošanās ceļā, kas nozīmē, ka tēviņš apaugļo mātīti. Mātīte dēj tūkstošiem oliņu, kas izšķiļas par maziem kāpuriem.3,4,5. Kāpuri, kas ir apmēram 1 milimetru gari, parasti barojas no putniem un grauzējiem.3 Kāpuri attīstās par nimfām. Nimfas barojas no siltasiņu zīdītājiem, tostarp mājdzīvniekiem un cilvēkiem.3 Tie paliek piestiprinājušās vairākas dienas, un, kad tie ir pietiekami „paēduši", tie nokrīt.1,4. Cilvēkiem visbiežāk piesūcas nimfas, jo tieši mazās ērces ir daudz grūtāk pamanīt nekā pilnībā pieaugušas ērces. Tā rezultātā lielāko daļu boreliožu ierosina nimfas.2. Visbeidzot nimfa attīstās par pilnībā pieaugušu ērci. Pieauguši ērču tēviņi ir apmēram 7-15 mm gari. Atkarībā no ērču sugas, ērces lielums var variēt no 0,5 līdz 15 mm.1 Pilnībā pieauguši tēviņi vairs nepieķeras saimnieka organismam, bet pieaugušām mātītēm ir vajadzīga ...
17. Ulusal Çocuk Cerrahisi Hemşireliği Kongresi 30 Ekim - 2 Kasım October - 2 November 2013 Eskişehir Ulusal Çocuk Cerrahisi Hemşireliği Kongresi Kurulları KONGRE ONURSAL ÜYELERİ Prof.
SQL: SELECT distinct t.name, tt.term_id FROM kas_wp_terms AS t INNER JOIN kas_wp_term_taxonomy AS tt ON tt.term_id = t.term_id INNER JOIN kas_wp_term_relationships AS tr ON tr.term_taxonomy_id = tt.term_taxonomy_id JOIN kas_wp_posts p ON tr.object_id=p.id AND p.post_status=publish WHERE `tt`.taxonomy=post_tag AND tt.parent = ...
SQL: SELECT distinct t.name, tt.term_id FROM kas_wp_terms AS t INNER JOIN kas_wp_term_taxonomy AS tt ON tt.term_id = t.term_id INNER JOIN kas_wp_term_relationships AS tr ON tr.term_taxonomy_id = tt.term_taxonomy_id JOIN kas_wp_posts p ON tr.object_id=p.id AND p.post_status=publish WHERE `tt`.taxonomy=post_tag AND tt.parent = ...
Guys, do pray for my behalf. Sure na akong kukuha ng REMOVAL EXAMS for Surgery and General Pathology. I dont have the guts to tell my parents that I am a candidate for such exams. Di kasi aabot ng 75 ang aking grades for both of em subjects, nasa 70.00-74.49 lang. Pero grabeng kayod na ako makuha lang yang 70-74.49 na grade. Please pray for me. Thanks. Until then, di pa masusundan itong entry ko ...
jangan lupa kasi komentar. oiya, kalau ada request tentang artikel dll, komen ajah ya... mau tanya PR juga boleh, terutama al biologi. nanti diusahakan buat dibikinin artikelnya... ok, tengkyu dah mw baca!!! jangan lupa like page-nya n follow d fb yah,,,. ...
Hope youre alright mommy liz! hay preho tayo ng pmroleba, co-pay here, co-pay there, before you know it, ayon na! laki na ng medical bill just because of co-pay We move from on primary care physician to another din kapag hindi kami satisfied sa services at ofcourse sa bill Youre young pa naman kaya next time that happens, just relax and wait for a little bit before heading to the E-room kasi mahal nga. ...
Collistar ir jauna Itālijas ekskluzīvās kosmētikas sērija, kas, pateicoties tās straujajai attīstībai un izplatībai, ir kļuvusi par vienu no vadošajām kosmētikas sērijām starptautiskajā kosmētikas tirgū. Collistar ir ieņēmusi vadošo pozīciju tirgū, pateicoties tās inovatīvajiem un unikālajiem produktiem, kuru sortimentā ietilpst produkti, kas aizkavē celulīta rašanos un ādas novecošanos; produkti, kas piešķir enerģiju, un aromterapijas produkti; dažādu veidu ādas kopšanas produkti; produkti aizsardzībai pret saules kaitīgo iedarbību; paštonējošie ķermeņa kopšanas un sejas produkti; produkti vīriešiem; matu kopšanas produkti un ikgadējie make-up produkti ar jaunām kolekcijām.. ...
3-oxoacyl-(acyl-carrier-protein) reductase - Wikipedia  3-oxoacyl-(acyl-carrier-protein) reductase - Wikipedia
... acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase ... Fatty acid synthase. *Beta-ketoacyl-ACP synthase. *Β-Ketoacyl ACP reductase. *3-Hydroxyacyl ACP dehydrase ... Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP ... Prescott DJ, Vagelos PR (1972). "Acyl carrier protein". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269-311. doi:10.1002/ ...
more infohttps://en.wikipedia.org/wiki/Beta-Ketoacyl_ACP_reductase
3-oxoacyl-[acyl-carrier-protein] synthase 3 - DrugBank  3-oxoacyl-[acyl-carrier-protein] synthase 3 - DrugBank
... acyl-carrier-protein] synthase 3. Q9F6D4. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. ... acyl-carrier-protein] synthase 3. Details. Name. 3-oxoacyl-[acyl-carrier-protein] synthase 3. Kind. protein. Organism. ...
more infohttps://www.drugbank.ca/bio_entities/BE0002680
RCSB PDB - Protein Feature View 









 - 3-oxoacyl-[acyl-carrier-protein] synthase 3 - C5CAR9 (C5CAR9 MICLC)  RCSB PDB - Protein Feature View - 3-oxoacyl-[acyl-carrier-protein] synthase 3 - C5CAR9 (C5CAR9 MICLC)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. UniProt ... Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN * ... This protein in other organisms (by gene name): C5CAR9 - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC ...
more infohttp://www.rcsb.org/pdb/protein/C5CAR9
fabH - 3-oxoacyl-[acyl-carrier-protein] synthase 3 - Staphylococcus aureus (strain MW2) - fabH gene & protein  fabH - 3-oxoacyl-[acyl-carrier-protein] synthase 3 - Staphylococcus aureus (strain MW2) - fabH gene & protein
Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the ... Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP ... acyl-carrier-protein] synthase activity Source: InterPro. *beta-ketoacyl-acyl-carrier-protein synthase III activity Source: ... acyl-carrier-protein] synthase 3UniRule annotation. Manual assertion according to rulesi ...
more infohttps://www.uniprot.org/uniprot/Q8NXE2
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
... acyl-carrier-protein] synthase, mitochondrial. ... acyl-CoA metabolic process 30 medium-chain fatty acid ... acyl-carrier-protein] synthase, mitochondrial. Complete proteome 20,231 ...
more infohttps://pharos.nih.gov/idg/targets/Q9NWU1
Diverse protein regulations on PHA formation in Ralstonia eutropha on short chain organic acids  Diverse protein regulations on PHA formation in Ralstonia eutropha on short chain organic acids
... acyl-carrier-protein]reductase, fatty acid/phosphlipid synthesis protein, fatty acid-CoA ligase, and acetyl/propionyl-CoA ... probable acyl-CoA dehydrogenase, probable multi-domain beta keto-acyl synthase, and acetyl/propionyl-CoA carboxylase involved ... Enoyl-[acyl-carrier-protein] reductase (FabI). 4. 27 (23). P54616. Bacillus subtilis. Fatty acid biosynthesis. ... SsrA-binding protein. 4. 41 (25). Q83N13. Tropheryma whipplei. Protein biosynthesis. Foldase protein. 2. 24 (21). P24327. ...
more infohttp://www.ijbs.com/v05p0215.htm
ENZYME entry 2.3.1.179  ENZYME entry 2.3.1.179
Beta-ketoacyl-[acyl-carrier-protein] synthase II. Alternative Name(s). 3-oxoacyl-acyl carrier protein synthase I.. ... Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] <=> (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein ...
more infohttps://enzyme.expasy.org/EC/2.3.1.179
RCSB PDB 









- 1MZS: CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic...  RCSB PDB - 1MZS: CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic...
... acyl-carrier-protein] synthase III A 317 Escherichia coli EC#: 2.3.1.180 IUBMB Mutation: C112X Gene Name(s): fabH b1091 JW1077 ... CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor. *DOI: ... Interactions are determined by geometric criteria as described in K. Stierand, M. Rarey (2010), Drawing the PDB: Protein-ligand ... Interactions are determined by geometric criteria as described in K. Stierand, M. Rarey (2010), Drawing the PDB: Protein-ligand ...
more infohttp://www.rcsb.org/pdb/explore/litView.do?structureId=1MZS
Fatty acid synthase - Wikipedia  Fatty acid synthase - Wikipedia
... acyl-carrier-protein synthase activity]. • acyl-[acyl-carrier-protein hydrolase activity]. • hydrolase activity. • palmitoyl-[ ... fatty acid synthase activity. • myristoyl-[acyl-carrier-protein hydrolase activity]. • enoyl-[acyl-carrier-protein reductase ( ... acyl-carrier-protein dehydratase activity]. • protein homodimerization activity. • catalytic activity. • [acyl-carrier-protein ... identical protein binding. • oleoyl-[acyl-carrier-protein hydrolase activity]. • oxidoreductase activity. • 3-oxoacyl-[ ...
more infohttps://en.wikipedia.org/wiki/Fatty_acid_synthase
The complete genomic sequence of Nocardia farcinica IFM 10152 | PNAS  The complete genomic sequence of Nocardia farcinica IFM 10152 | PNAS
... acyl-CoA synthetases (family 6), acyl-CoA dehydrogenases (family 8), enoyl-CoA hydratase/isomerase family proteins (family 11 ... 4B ). This cluster includes genes coding for two polyketide synthases (NbtB and -C), three nonribosomal peptide synthetases ( ... Antigen 85 family proteins of M. tuberculosis are known as fibronectin-binding proteins (19). M. tuberculosis has four proteins ... Comparison with other bacterial RpoB proteins suggested that the nocardial RpoB protein is sensitive to rifampin. In contrast, ...
more infohttps://www.pnas.org/content/101/41/14925?ijkey=c54739eb1195e633fa6765655ab18c566715d0f5&keytype2=tf_ipsecsha
SWISS-MODEL Template Library | 3fk5  SWISS-MODEL Template Library | 3fk5
... acyl carrier protein) synthase III, FabH (Xoo4209) from Xanthomonas oryzae pv. oryzae KACC10331 ... acyl carrier protein) synthase III, FabH (Xoo4209) from Xanthomonas oryzae pv. oryzae KACC10331; X-RAY DIFFRACTION 2.05 Å SMTL ... 3-oxoacyl-synthase III. Oligo-state. monomer. SMTL ID. 3fk5.2. Ligands. -. Polypeptides. 3-oxoacyl-synthase III. Oligo-state. ...
more infohttps://swissmodel.expasy.org/templates/3fk5
Different Roles of EIIABMan and EIIGlc in Regulation of Energy Metabolism, Biofilm Development, and Competence in Streptococcus...  Different Roles of EIIABMan and EIIGlc in Regulation of Energy Metabolism, Biofilm Development, and Competence in Streptococcus...
... acyl-carrier-protein) synthase III. 0.253. 0.0013806. 0.52. 0.014. F-AGTTATCGGTGCAGAAGTTC, R-AAAGGGTGACGAAACAGC. ... Putative starch (bacterial glycogen) synthase. 12.283. 4.70E−06. SMU.935. Putative amino acid ABC transporter, permease protein ... Conserved hypothetical protein. 23.54. 3.40E−06. SMU.936. Putative amino acid ABC transporter, ATP-binding protein. 18.147. ... Hypothetical protein. 0.295. 0.0023821. SMU.1516. Putative histidine kinase CovS VicK homolog. 0.284. 0.0004549. 0.55. 0.017. F ...
more infohttps://jb.asm.org/content/188/11/3748/figures-only
HOGENOM: PROAS 1 PE1015  HOGENOM: PROAS 1 PE1015
... acyl-carrier-protein] synthase activity; IEA:HAMAP. DR GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III ... acyl-carrier-protein] = CC acetoacetyl-[acyl-carrier-protein] + CoA + CO(2). CC -!- PATHWAY: Lipid metabolism; fatty acid ... acyl-carrier-protein] synthase III;AltName: DE Full=Beta-ketoacyl-ACP synthase III; (PROAS_1.PE1015). GN Name=fabH; ... acyl-carrier-protein] synthase 3; EC=2.3.1 DE 180;AltName: Full=3-oxoacyl-[ ...
more infohttp://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-id?query=PROAS_1_PE1015&db=HOGENOM&ident=ACNUC6774
Drug CategoriesBrowse DrugBank Categories - DrugBank  Drug CategoriesBrowse DrugBank Categories - DrugBank
Acyl-Carrier-Protein) Synthase. Not Available. 1. 1. Details. 4-Hydroxycoumarins. Substances found in many plants, containing ... Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small mo... more. 1. 3. Details. ... Enzymes from the transferase class that catalyze the transfer of acyl groups from donor... more. 1. 0. Details. ... 3-Hydroxysteroid Dehydrogenases, antagonists & inhibitors. Not Available. 1. 4. Details. 3-Oxoacyl-( ...
more infohttps://www.drugbank.ca/categories
MYCOBACTERIUM TUBERCULOSIS (mycobacterium tuberculosis): Topics by WorldWideScience.org  MYCOBACTERIUM TUBERCULOSIS (mycobacterium tuberculosis): Topics by WorldWideScience.org
Analysis of predicted CD8 + T cell epitopes from proteins encoded by the specific RD regions of Mycobacterium tuberculosis for ... Molecular models of tryptophan synthase from Mycobacterium tuberculosis complexed with inhibitors Silveira, Nelson; Azevedo, ... Potential of mycobacterial excretory secretory protein antigens (sevatb ES-31, ES-43, EST-6 and ES-20) as biomarkers to detect ... Analysis of expression and regulatory functions of the ribosome-binding protein TypA in Mycobacterium tuberculosis under stress ...
more infohttps://worldwidescience.org/topicpages/multi/DE/m/mycobacterium+tuberculosis.html
KEGG PATHWAY: sys00780  KEGG PATHWAY: sys00780
fabF; beta ketoacyl-acyl carrier protein synthase [KO:K09458] [EC:2.3.1.179] ... acyl carrier protein) synthase II [KO:K09458] [EC:2.3.1.179] ... envM; enoyl-[acyl-carrier-protein] reductase [KO:K00208] [EC: ... fabZ; (3R)-hydroxymyristol acyl carrier protein dehydrase [KO:K02372] [EC:4.2.1.59] ... The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin ...
more infohttp://www.genome.jp/dbget-bin/www_bget?pathway+sys00780
KEGG PATHWAY: mmb00780  KEGG PATHWAY: mmb00780
... acyl-carrier-protein) synthase 2 [KO:K09458] [EC:2.3.1.179] ... beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ [KO: ... The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin ... Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. ... Biotin is covalently attached to biotin-dependent carboxylase by biotin protein ligase, also known as holocarboxylase synthase ...
more infohttp://www.genome.jp/dbget-bin/www_bget?pathway+mmb00780
SCOPe 2.05: Structural Classification of Proteins - extended  SCOPe 2.05: Structural Classification of Proteins - extended
... and ASTRAL compendium for protein structure and sequence analysis ... acyl-carrier-protein] synthase 3. Species: Escherichia coli [ ... acyl-carrier-protein] synthase 3. Species: Escherichia coli [TaxId:562]. Gene: fabH. Database cross-references and differences ... Description: Methanethiol-Cys 112 Inhibition Complex of E. Coli Ketoacyl Synthase III (FabH) and Coenzyme A. Class: transferase ... SCOPe: Structural Classification of Proteins - extended. Release 2.05 (updated 2016-01-14, stable release February 2015) ...
more infohttp://scop.berkeley.edu/pdb/code=2gyo&ver=2.05
SCOPe 2.06: Structural Classification of Proteins - extended  SCOPe 2.06: Structural Classification of Proteins - extended
... and ASTRAL compendium for protein structure and sequence analysis ... acyl-carrier-protein] synthase III. Species: Escherichia coli [ ... Description: CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor ... SCOPe: Structural Classification of Proteins - extended. Release 2.06 (updated 2017-12-21, stable release February 2016) ...
more infohttp://scop.berkeley.edu/pdb/code=1mzs&ver=2.06
ppsE - Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsE - Mycobacterium bovis (strain ATCC BAA-935 /...  ppsE - Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsE - Mycobacterium bovis (strain ATCC BAA-935 /...
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl- [acyl-carrier-protein] + CO2 + [acyl-carrier-protein ... Pfam protein domain database. More...Pfami. View protein in Pfam. PF00698. Acyl_transf_1. 1 hit. PF00668. Condensation. 1 hit. ... Pfam protein domain database. More...Pfami. View protein in Pfam. PF00698. Acyl_transf_1. 1 hit. PF00668. Condensation. 1 hit. ... View protein in PROSITE. PS00606. B_KETOACYL_SYNTHASE. 1 hit. PS50075. CARRIER. 1 hit. ...
more infohttp://www.uniprot.org/uniprot/Q7TXL6
  • 13387 FT /colour=9 FT /domain="HMMPfam:PF03235;Protein of unknown function FT DUF262;1.3e-19;codon 1-247" FT /id="cj81-176u_01" FT /label=HMMPfam FT /note="HMMPfam hit to PF03235, Protein of unknown function FT DUF262, score 1.3e-19" FT misc_feature 14042. (lshtm.ac.uk)
  • 14320 FT /colour=9 FT /domain="HMMPfam:PF07510;Protein of unknown function FT (DUF1524);8.7e-10;codon 466-558" FT /id="cj81-176u_01" FT /label=HMMPfam FT /note="HMMPfam hit to PF07510, Protein of unknown function FT (DUF1524), score 8.7e-10" FT CDS complement(join(15828. (lshtm.ac.uk)
  • Contains match to PF00672 FT HAMP domain (Score 31.5 E() 2.5e-06) and PF00015 FT methyl-accepting chemotaxis protein (MCP) signalling FT domain (Score 43.4 E() 5.5e-10). (lshtm.ac.uk)
  • 24237) FT /colour=9 FT /domain="HMMPfam:PF00015;Methyl-accepting chemotaxis FT protein (MCP) s;5.8e-10;codon 356-591" FT /id="cj81-176u_03c" FT /label=HMMPfam FT /note="HMMPfam hit to PF00015, Methyl-accepting chemotaxis FT protein (MCP) s, score 5.8e-10" FT misc_feature complement(23605. (lshtm.ac.uk)