An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 2.3.1.41.
Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.
A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.
An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.
Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
This enzyme catalyzes the transacylation of malonate from MALONYL CoA to activated holo-ACP, to generate malonyl-(acyl-carrier protein), which is an elongation substrate in FATTY ACIDS biosynthesis. It is an essential enzyme in the biosynthesis of FATTY ACIDS in all BACTERIA.
A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Proteins found in any species of bacterium.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.
Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2.
Transport proteins that carry specific substances in the blood or across cell membranes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The addition of an organic acid radical into a molecule.
A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
A diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
A genus of gram-positive bacteria whose spores are round to oval and covered by a sheath.
The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).
S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.
A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to form COENZYME A and acetyl-acyl-carrier protein.
The rate dynamics in chemical or physical systems.
An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.
Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.
Polyacenes with four ortho-fused benzene rings in a straight linear arrangement. This group is best known for the subclass called TETRACYCLINES.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Proteins prepared by recombinant DNA technology.
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
... acyl-carrier-protein synthase activity]. • acyl-[acyl-carrier-protein hydrolase activity]. • hydrolase activity. • palmitoyl-[ ... fatty acid synthase activity. • myristoyl-[acyl-carrier-protein hydrolase activity]. • enoyl-[acyl-carrier-protein reductase ( ... acyl-carrier-protein dehydratase activity]. • protein homodimerization activity. • catalytic activity. • [acyl-carrier-protein ... identical protein binding. • oleoyl-[acyl-carrier-protein hydrolase activity]. • oxidoreductase activity. • 3-oxoacyl-[ ...
... acyl-carrier-protein] Thus, the two substrates of this enzyme are (Z)-hexadec-11-enoyl-[acyl-carrier-protein] and malonyl-[acyl ... The systematic name of this enzyme class is (Z)-hexadec-11-enoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-pr otein] C- ... acyl-carrier-protein], CO2, and acyl-carrier-protein. This enzyme belongs to the family of transferases, specifically those ... acyl-carrier-protein] + malonyl-[acyl-carrier-protein] ⇌ {\displaystyle \rightleftharpoons } (Z)-3-oxooctadec-13-enoyl-[acyl- ...
... acyl carrier protein] + CoA + CO2 Thus, the two substrates of this enzyme are acetyl-CoA and malonyl-[acyl-carrier-protein], ... acyl-carrier-protein] synthase III enzyme is designated mtFabH and is a crucial link between the fatty acid synthase-I and ... acyl-carrier-protein] synthase III (EC 2.3.1.180) is an enzyme that catalyzes the chemical reaction acetyl-CoA + malonyl-[acyl ... β-Ketoacyl-acyl-carrier-protein synthase III is involved in the dissociated (or type II) fatty-acid biosynthesis system that ...
... acyl-carrier-protein) reductase Witkowski, Andrzej; Joshi, Anil K.; Smith, Stuart (2002). "Mechanism of the β-Ketoacyl Synthase ... acyl-carrier-protein) synthase III (FabH)". Biotechnology and Bioengineering. 112 (8): 1613-1622. doi:10.1002/bit.25583. ISSN ... acyl-carrier-protein) synthase III (FabH)". Biotechnology and Bioengineering. 112 (8): 1613-22. doi:10.1002/bit.25583. PMID ... and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". Journal of Biological ...
... acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase ... Fatty acid synthase. *Beta-ketoacyl-ACP synthase. *Β-Ketoacyl ACP reductase. *3-Hydroxyacyl ACP dehydrase ... Other names in common use include beta-ketoacyl-[acyl-carrier protein](ACP) reductase, beta-ketoacyl acyl carrier protein (ACP ... Prescott DJ, Vagelos PR (1972). "Acyl carrier protein". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269-311. doi:10.1002/ ...
... acyl-carrier-protein) synthase MeSH D08.811.913.050.625 - phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050.646 ... acyl-carrier-protein) reductase (nadh) MeSH D08.811.682.660.390 - enoyl-(acyl-carrier protein) reductase (nadph, b-specific) ... acyl-carrier protein s-acetyltransferase MeSH D08.811.913.050.134.060 - acetyl-CoA C-acetyltransferase MeSH D08.811.913.050. ... acyl-carrier protein s-malonyltransferase MeSH D08.811.913.050.173 - 1-acylglycerol-3-phosphate O-acyltransferase MeSH D08.811. ...
... glyceryl-S-ACP synthase) and Agg3 (acyl carrier protein). The acyl chain is taken from primary metabolism as a 3-oxoacyl-CoA ... Sun, Yuhui; Hong, Hui; Gillies, Fraser; Spencer, Jonathan B.; Leadlay, Peter F. (2008). "Glyceryl-S-Acyl Carrier Protein as an ... The members of the agglomerins differ only in the composition of the acyl chain attached to the tetronate ring. They possess ... The glyceryl-S-ACP and 3-oxoacyl-CoA thioester are joined by Agg1, a FabH-like ketosynthase, forming new C-C and C-O bonds. The ...
... acyl-carrier-protein) synthase II EC 2.3.1.180: beta-ketoacyl-(acyl-carrier-protein) synthase III EC 2.3.1.181: lipoyl(octanoyl ... acyl-carrier-protein) S-acetyltransferase EC 2.3.1.39: (acyl-carrier-protein) S-malonyltransferase EC 2.3.1.40: acyl-(acyl- ... acyl-carrier protein) synthase EC 2.7.7.67: CDP-archaeol synthase EC 2.7.7.68: 2-phospho-L-lactate guanylyltransferase EC 2.7. ... acyl-carrier-protein) synthase EC 2.3.1.208: 4-hydroxycoumarin synthase EC 2.3.1.209: dTDP-4-amino-4,6-dideoxy-D-glucose ...
... acyl-carrier-protein Thus, the two substrates of this enzyme are acyl-acyl-carrier-protein and malonyl-acyl-carrier-protein, ... acyl-malonyl(acyl-carrier-protein)-condensing enzyme, acyl-malonyl acyl carrier protein-condensing enzyme, beta-ketoacyl acyl ... The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase ( ... beta-ketoacyl-acyl carrier protein synthetase, beta-ketoacyl-[acyl carrier protein] synthase, beta-ketoacylsynthase, condensing ...
Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO (March 2001). "Inhibition of beta-ketoacyl-acyl carrier protein synthases ... Middleton B (April 1973). "The oxoacyl-coenzyme A thiolases of animal tissues". Biochem. J. 132 (4): 717-30. doi:10.1042/ ... Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to ... or acyl carrier protein (ACP). All thiolases, whether they are biosynthetic or degradative in vivo, preferentially catalyze the ...
The reaction proceeds as such: acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] → a 3-oxoacyl-[acyl-carrier ... acyl-carrier protein] + CO2 + [acyl-carrier protein In Streptococcus pneumoniae, for example, synthase II is used as an ... The reaction proceeds as such: (Z)-hexadec-11-enoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] → (Z)-3-oxooctadec- ... "BRENDA - Information on EC 2.3.1.41 - beta-ketoacyl-[acyl-carrier-protein] synthase I". www.brenda-enzymes.org. Retrieved 2016- ...
enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) Ja 1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Ja ... pyridoxal 5'-phosphate synthase Ja 1.4.3.13 protein-lysine 6-oxidase Ja ... Glycerol-3-fosfaatdehydrogenase (NAD+) Ja 1.1.1.9 Xylitol + NAD+ ⇌. {\displaystyle \rightleftharpoons }. D-xylulose + NADH + H+ ... R,R)-butaan-2,3-diol + NAD+ ⇌. {\displaystyle \rightleftharpoons }. (R)-Acetoïne + NADH + H+ (R,R)-butaanedioldehydrogenase ...
... acyl-carrier-protein synthase activity]. • acyl-[acyl-carrier-protein hydrolase activity]. • hydrolase activity. • palmitoyl-[ ... fatty acid synthase activity. • myristoyl-[acyl-carrier-protein hydrolase activity]. • enoyl-[acyl-carrier-protein reductase ( ... acyl-carrier-protein dehydratase activity]. • protein homodimerization activity. • catalytic activity. • [acyl-carrier-protein ... identical protein binding. • oleoyl-[acyl-carrier-protein hydrolase activity]. • oxidoreductase activity. • 3-oxoacyl-[ ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. UniProt ... Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN * ... This protein in other organisms (by gene name): C5CAR9 - Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC ...
... acyl-carrier-protein] synthase 3. Q9F6D4. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. ... acyl-carrier-protein] synthase 3. Details. Name. 3-oxoacyl-[acyl-carrier-protein] synthase 3. Kind. protein. Organism. ...
Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the ... Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP ... acyl-carrier-protein] synthase activity Source: InterPro. *beta-ketoacyl-acyl-carrier-protein synthase III activity Source: ... acyl-carrier-protein] synthase 3UniRule annotation. Manual assertion according to rulesi ...
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP ... acyl-carrier-protein] synthase 1 (EC:2.3.1.41*Search proteins in UniProtKB for this EC number. ... acyl-carrier-protein] synthase 1 OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) OX=652616 GN=kasA PE=2 SV ... acyl-carrier-protein] synthase 1. ). MYCTU. 416. Beta-ketoacyl-[acyl-carrier-protein] synthase II. Mycobacterium leprae 3125609 ...
... acyl-carrier-protein] synthase, mitochondrial. ... acyl-CoA metabolic process 30 medium-chain fatty acid ... acyl-carrier-protein] synthase, mitochondrial. Complete proteome 20,231 ...
... acyl-carrier-protein] synthase 3 - Escherichia coli (strain K12). Help ...
... entry for 4z8d.3. Antibacterial FabH Inhibitors with Validated Mode of Action in Haemophilus Influenzae by in vitro resistance ... acyl-carrier-protein] synthase 3: AB. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ... 4LB.3: 17 residues within 4Å:*. Chain B: W.32, R.36, T.37, C.112, I.156, L.189, M.207, G.209, N.210, V.212, F.213, A.216, A.246 ... 3 PLIP interactions:. 3 interactions with chain A. *. Hydrogen bonds: A:S.120, A:L.179 ...
3-oxoacyl-[acyl-carrier-protein] synthase 3. Psychromonas ingrahamii (strain 37) ... acyl-carrier-protein (ACP)] synthase III. IPR013751PF08545. 230-319. 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C- ... acyl-carrier-protein] synthase 3 UniProtKBInterProSTRINGInteractive Modelling. 319 aa; Sequence (Fasta) ...
Acyl-Carrier-Protein) Synthase / metabolism * Actins * Animals * Antigens, Bacterial / genetics * Antigens, Bacterial / ... Thus, virulence-related protein secretion is localized in mycobacteria, suggesting new potential therapeutic targets, which are ...
... acyl-carrier-protein) synthase III. 0.253. 0.0013806. 0.52. 0.014. F-AGTTATCGGTGCAGAAGTTC, R-AAAGGGTGACGAAACAGC. ... Putative starch (bacterial glycogen) synthase. 12.283. 4.70E−06. SMU.935. Putative amino acid ABC transporter, permease protein ... Conserved hypothetical protein. 23.54. 3.40E−06. SMU.936. Putative amino acid ABC transporter, ATP-binding protein. 18.147. ... Hypothetical protein. 0.295. 0.0023821. SMU.1516. Putative histidine kinase CovS VicK homolog. 0.284. 0.0004549. 0.55. 0.017. F ...
... acyl-carrier-protein] synthase activity; IEA:HAMAP. DR GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III ... acyl-carrier-protein] = CC acetoacetyl-[acyl-carrier-protein] + CoA + CO(2). CC -!- PATHWAY: Lipid metabolism; fatty acid ... acyl-carrier-protein] synthase III;AltName: DE Full=Beta-ketoacyl-ACP synthase III; (PROAS_1.PE1015). GN Name=fabH; ... acyl-carrier-protein] synthase 3; EC=2.3.1 DE 180;AltName: Full=3-oxoacyl-[ ...
fabF; beta ketoacyl-acyl carrier protein synthase [KO:K09458] [EC:2.3.1.179] ... acyl carrier protein) synthase II [KO:K09458] [EC:2.3.1.179] ... envM; enoyl-[acyl-carrier-protein] reductase [KO:K00208] [EC: ... fabZ; (3R)-hydroxymyristol acyl carrier protein dehydrase [KO:K02372] [EC:4.2.1.59] ... The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin ...
... acyl-carrier-protein) synthase 2 [KO:K09458] [EC:2.3.1.179] ... beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ [KO: ... The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin ... Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. ... Biotin is covalently attached to biotin-dependent carboxylase by biotin protein ligase, also known as holocarboxylase synthase ...
Acyl-Carrier-Protein) Synthase / genetics * Abscisic Acid / metabolism* * Abscisic Acid / pharmacology* * Arabidopsis / ...
Acyl-Carrier-Protein) Synthase. Not Available. 1. 1. Details. 4-Hydroxycoumarins. Substances found in many plants, containing ... Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small mo... more. 1. 3. Details. ... Enzymes from the transferase class that catalyze the transfer of acyl groups from donor... more. 1. 0. Details. ... 3-Hydroxysteroid Dehydrogenases, antagonists & inhibitors. Not Available. 1. 4. Details. 3-Oxoacyl-( ...
Homologous to beta-keto-acyl-acyl-carrier protein synthase. PA0998. pqsC. 4.5. 0.0031. Homologous to beta-keto-acyl-acyl- ... Membrane protein component of ABC phosphate transporter. PA5368. pstC. 27.7. 3.9E−09. Membrane protein component of ABC ... Binding protein component of ABC phosphonate transporter. PA3384. phnC. 27.2. 2.5E−07. ATP-binding component of ABC phosphonate ... Probable chemotaxis protein methyltransferase. PA0176. aer2. 15.4. 0.0001. Aerotaxis transducer methyl-accepting chemotaxis ...
... acyl carrier protein) synthase; 4, acetyl-CoA acetyltransferase; 5, 3-hydroxyacyl-CoA dehydrogenase; 6, enoyl-CoA hydratase; 7 ... enoyl-(acyl carrier protein) reductase (NADH); 8, acetate CoA-transferase; 9, butyrate kinase; 10, citrate synthase; 11, ... protein plus protein, 16S plus 16S, metabolomics plus metabolomics, 16S plus protein, protein plus metabolomics, and 16S plus ... of protein were normalized as described below (42): Normalized. SC. i. =. ∑. j. =. 1. M. ∑. k. =. 1. N. SC. k. M. ∑. k. =. 1. N ...
... and ASTRAL compendium for protein structure and sequence analysis ... acyl-carrier-protein] synthase 3. Species: Escherichia coli [ ... acyl-carrier-protein] synthase 3. Species: Escherichia coli [TaxId:562]. Gene: fabH. Database cross-references and differences ... Description: Methanethiol-Cys 112 Inhibition Complex of E. Coli Ketoacyl Synthase III (FabH) and Coenzyme A. Class: transferase ... SCOPe: Structural Classification of Proteins - extended. Release 2.05 (updated 2016-01-14, stable release February 2015) ...
... and ASTRAL compendium for protein structure and sequence analysis ... acyl-carrier-protein] synthase III. Species: Escherichia coli [ ... Description: CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor ... SCOPe: Structural Classification of Proteins - extended. Release 2.06 (updated 2017-12-21, stable release February 2016) ...
... acyl-carrier-protein] synthase i Enzyme Information. 2.3.1.179. Beta-ketoacyl-[acyl-carrier-protein] synthase II. ... Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier- protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein ... acyl-carrier-protein].. -!- Involved in the dissociated (or type II) fatty acid biosynthesis system that occurs in plants and ... CATH: Protein Structure Classification Database by I. Sillitoe, N. Dawson, T. Lewis, D. Lee, J. Lees, C. Orengo is licensed ...
... acyl-carrier-protein synthase activity]. • acyl-[acyl-carrier-protein hydrolase activity]. • hydrolase activity. • palmitoyl-[ ... fatty acid synthase activity. • myristoyl-[acyl-carrier-protein hydrolase activity]. • enoyl-[acyl-carrier-protein reductase ( ... acyl-carrier-protein dehydratase activity]. • protein homodimerization activity. • catalytic activity. • [acyl-carrier-protein ... identical protein binding. • oleoyl-[acyl-carrier-protein hydrolase activity]. • oxidoreductase activity. • 3-oxoacyl-[ ...
... acyl carrier protein) synthase. 0298. 0285. PE 5. 0728. 0701. Ribosomal protein L3. ... foIP1, dihydropteroate synthase 1. *. ↵ a CHP, conserved hypothetical protein, with additional annotation derived from the ... a Abbreviations: HP, hypothetical proteins; CHP, conserved hypothetical proteins; OD, optical density. ... and is related to mycolic acid cyclopropane synthase family proteins such as CmaA1 (MT3499/Rv3392c) and PcaA (MT0486/Rv0470c) ( ...
... acyl-carrier-protein] synthase II (FabF; [EC:2.3.1.179]) and 3-oxoacyl-[acyl-carrier protein] reductase (FabG; [EC:1.1.1.100 ... such as sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase, and acetyl-CoA carboxylase in the liver (Kim ... Lactobacillus reuteri has been reported to be beneficial for the expression of intestinal tight junction (TJ) proteins in ... TJ protein expression was detected in the three groups using immunohistochemical staining. ZO-1 expression was significantly ...
... acyl-carrier-protein] synthase II of Streptococcus equi ssp. zooepidemicus which confers protective effects Li Yi , Weiping ... acyl-carrier-protein] synthase II of Streptococcus equi ssp. zooepidemicus which confers protective effects Li Yi , Weiping ... Identification of a novel protective antigen, 3-oxoacyl-[ ... Identification of a novel protective antigen, 3-oxoacyl-[ ...
... acyl-carrier-protein]reductase, fatty acid/phosphlipid synthesis protein, fatty acid-CoA ligase, and acetyl/propionyl-CoA ... probable acyl-CoA dehydrogenase, probable multi-domain beta keto-acyl synthase, and acetyl/propionyl-CoA carboxylase involved ... Enoyl-[acyl-carrier-protein] reductase (FabI). 4. 27 (23). P54616. Bacillus subtilis. Fatty acid biosynthesis. ... SsrA-binding protein. 4. 41 (25). Q83N13. Tropheryma whipplei. Protein biosynthesis. Foldase protein. 2. 24 (21). P24327. ...
... acyl-CoA synthetases (family 6), acyl-CoA dehydrogenases (family 8), enoyl-CoA hydratase/isomerase family proteins (family 11 ... 4B ). This cluster includes genes coding for two polyketide synthases (NbtB and -C), three nonribosomal peptide synthetases ( ... Antigen 85 family proteins of M. tuberculosis are known as fibronectin-binding proteins (19). M. tuberculosis has four proteins ... Comparison with other bacterial RpoB proteins suggested that the nocardial RpoB protein is sensitive to rifampin. In contrast, ...
... acyl-carrier-protein] synthase I [EC:2.3.1.41]. K00652 8-amino-7-oxononanoate synthase [EC:2.3.1.47]. ... medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]. K01909 long-chain-fatty-acid--[acyl-carrier-protein] ligase [ ... minimal PKS acyl carrier protein. K05939 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[ ... BtrI acyl-carrier protein]--L-glutamate ligase [EC:6.2.1.39]. K13563 ribostamycin:4-(gamma-L-glutamylamino)-(S)-2- ...
... acyl-carrier-protein) synthase III. 1 (up). 58 (55). gi/83952158. Fatty acid biosynthesis. ... acyl-carrier-protein]reductase (FabI) and fatty acid-CoA ligase [11]. In our study, FabI and β-ketoacyl carrier protein ... 280 proteins were totally identified and 188 proteins were separated as acetate-related proteins in BL-4. Acetate was converted ... BL-4 proteins (15 μg). Arrows indicate different patterns of proteins on the gel. 1, molecular size marker; 2, acetate-fed ...
... acyl-malonyl acyl carrier protein-condensing enzyme; beta-ketoacyl synthase; Beta-ketoacyl-ACP synthase; type II mitochondrial ... acyl-carrier-protein] synthase, mitochondrial; 3-oxoacyl-acyl-carrier-protein synthase; ... acyl-CoA metabolic process short-chain fatty acid biosynthetic process medium-chain fatty acid biosynthetic process ... Human recombinant protein fragment corresponding to amino acids 78-343 of human OXSM produced in E.coli. ...
... acyl-carrier-protein) synthase K09458 418 109 ( -) 31 0.347 98 ,-, 1 gtn:GTNG_1776 Predicted xylanase/chitin deacetylase 208 ... pfk:PFAS1_21145 copper resistance protein CopB K07233 295 104 ( -) 30 0.345 58 ,-, 1 pman:OU5_0390 acyl-CoA synthetase K00666 ... sld:T261_3326 Putative citrate synthase 2 K01647 369 100 ( -) 29 0.310 126 ,-, 1 sro:Sros_6351 conserved hypothetical protein ... spaa:SPAPADRAFT_60204 hypothetical protein K15445 314 112 ( -) 31 0.314 51 ,-, 1 wma:WM2015_1541 phosphoenolpyruvate synthase ...
  • The basis of this analysis are protein sequences of NifH (nitrogenase reductase), LuxA (Luciferase alpha subunit) and LuxS (Sribosyl homocysteine lyase) from 30, 17, 25 species of bacteria respectively. (oaji.net)
  • According to the results obtained, the most highly evolved group of organisms with respect to their nitrogenase reductase protein is that of Desulfovibrio vulgaris and Chlorobium phaeobacteriodes. (oaji.net)
  • GO:0004319 (F) enoyl- [acyl-carrier-protein] reductase (NAD. (pku.edu.cn)
  • Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (rcsb.org)
  • Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO 2 . (rcsb.org)
  • The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis. (genome.jp)
  • The systematic name of this enzyme class is acetyl-CoA:malonyl-[acyl-carrier-protein] C-acyltransferase. (wikipedia.org)
  • Although there is substantial structural homology among all bacterial FabH enzymes determined thus far, with two channels for binding of acyl-CoA and malonyl-ACP substrates and a conserved catalytic triad (C122, H258, N289 in mtFabH), mtFabH contains residues along the acyl-CoA binding channel that preferentially select for longer-chain substrates peaking with lauroyl-CoA (C12). (wikipedia.org)
  • The systematic name of this enzyme class is (Z)-hexadec-11-enoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-pr otein] C-acyltransferase (decarboxylating). (wikipedia.org)
  • An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. (bvsalud.org)
  • Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2. (cbrc.jp)
  • 3-oxoacyl-[acyl-carrier-protein] synthase 2 (KAS-II, FabF) is involved in the condensation step of fatty acid biosynthesis in which the malonyl donor group is decarboxylated and the resulting carbanion used to attack and extend the acyl group attached to the acyl carrier protein [1]. (jcvi.org)
  • The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. (pnas.org)
  • Putative protein-coding sequences were predicted by the glimmer program and then were manually confirmed and corrected by using the blastp ( 10 ) and frameplot programs ( 11 ), optimized to handle genomic-size sequences. (pnas.org)
  • This list of putative orthologs is based on a reciprocal best-blast (RBB) search between proteins found in the two genomes. (burkholderia.com)
  • A C. tepidum genomic region, encoding a putative quinone-interacting membrane-bound oxidoreductase (Qmo) complex ( CT0866-0868 ), hypothetical proteins ( CT0869-0875 ) and a sulfide : quinone oxidoreductase (SQR) homologue ( CT0876 ), was analysed for its role in anaerobic sulfur oxidation. (microbiologyresearch.org)
  • Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae. (ymdb.ca)
  • Fatty acid synthase ( FAS ) is an enzyme that in humans is encoded by the FASN gene . (wikipedia.org)
  • Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis . (wikipedia.org)
  • In M. tuberculosis, the beta-ketoacyl-[acyl-carrier-protein] synthase III enzyme is designated mtFabH and is a crucial link between the fatty acid synthase-I and fatty acid synthase-II pathways producing mycolic acids. (wikipedia.org)
  • An enzyme of the fatty acid synthase complex. (thefreedictionary.com)
  • curator_summary=Encodes a condensing enzyme KCS1 (3-ketoacyl-CoA synthase 1) which is involved in the critical fatty acid elongation process in wax biosynthesis. (salk.edu)
  • Thus, the two substrates of this enzyme are (3R)-3-hydroxyacyl-[acyl-carrier-protein] and NADP + , whereas its 3 products are 3-oxoacyl-[acyl-carrier-protein] , NADPH , and H + . (wikipedia.org)
  • The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP + oxidoreductase . (wikipedia.org)
  • Created page with ' Category:reaction == Reaction RXN-16625 == * direction: ** left-to-right * common-name: ** 3-oxoacyl-[acyl-carrier-protein] synthase * ec-number: ** [http://enzyme.expasy. (genouest.org)
  • INTRODUCTION: The purpose of this study was to investigate whether chronic exercise training attenuates fatty acid synthase, the rate-limiting enzyme for hepatic lipogenesis, and the accumulation of body fat by using obese Zucker rats (OZR) as a model. (pku.edu.cn)
  • A region within amino acids 2462-2511 of Human Fatty Acid Synthase (NP_004095.4). (abcam.com)
  • Western blot analysis of H-460 cell lysates using Rabbit anti fatty acid synthase antibody at a 1/200 dilution. (bio-rad-antibodies.com)
  • Western blot analysis of control and fatty acid synthase knockout HEK 293T cell lysate using Rabbit anti fatty acid synthase antibody at a 1/1000 dilution. (bio-rad-antibodies.com)
  • Rabbit anti fatty acid synthase antibody recognizes fatty acid synthase (FASN), also known as 3-oxoacyl-[acyl-carrier-protein] synthase. (bio-rad-antibodies.com)
  • A number of proteins were found to be induced in R. eutropha by using 1D-PAGE and nano-liquid chromatography tandem MS/MS. With the proteins being up-regulated, a dramatic change occurred in the induction of PHA metabolism, including fatty acid biosynthesis for acetate, β-oxidation for propionate and both for levulinic acid. (ijbs.com)
  • The organic acids induced several proteins involved in amino acid biosynthesis, purine and pyrimidine biosynthesis, and cofactor biosynthesis in R. eutropha , but the regulations had a great variation. (ijbs.com)
  • The information on proteins involved in different metabolic pathways, particularly the regulation of the enzymes in cells' responses to different organic acids, is invaluable to biosynthesis of PHA biopolymers. (ijbs.com)
  • During acetate metabolism proteins involved in the lipid metabolism and hexosamine biosynthesis were over-expressed in the acetate medium, while proteins involved in TCA cycle, pentose phosphate cycle and purine metabolism were down-regulated. (ijbs.com)
  • β-Ketoacyl-acyl-carrier-protein synthase III is involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. (wikipedia.org)
  • Most genomes encoding fatty acid biosynthesis contain a number of condensing enzymes, often of all three types: 1, 2 and 3. (jcvi.org)
  • These differential proteins were also involved in diverse intracellular pathways, such as fatty acid biosynthesis, arachidonic acid metabolism, and mucin type O -glycan biosynthesis. (biomedcentral.com)
  • Bacterial cells were disrupted in a lysis buffer containing 30 mM Tris, 2 M thiourea, 7 M urea, 4% CHAPS, 2% IPG buffer pH 3-10 and protease inhibitors and then subjected to sonication in order to solubilize as much as possible the bacterial proteins. (bvsalud.org)
  • Beta-ketoacyl-acyl carrier protein synthetase. (expasy.org)
  • Enzymes from the transferase class that catalyze the transfer of acyl groups from donor. (drugbank.ca)
  • Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease. (pnas.org)
  • Previously, pneumococcal adherence and invasion has been studied by gene expression analyses using RT-PCR [ 3 ] or microarrays [ 4 - 7 ]. (cdc.gov)
  • Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (bu.edu)
  • The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB ). (bu.edu)
  • Also knowledge abtained from the motif pattern analysis between Bradyrhizobium japonicum and Rhizobium leguminosarum NifH protein sequence are conserved and further analysis may show that there may be quorum sensing mediated gene regulation in host bacterium interaction. (oaji.net)
  • A homologue of the 3-oxoacyl-(acyl carrier protein) synthase III gene located in the glycosylation island of Pseudomonas syringae pv. (okayama-u.ac.jp)
  • 43. The method of claim 42, wherein said annotation is selected from the group consisting of assignment of a gene, assignment of a protein, assignment of a subsystem, assignment of a confidence rating, reference to genome annotation information and reference to a publication. (patentsencyclopedia.com)
  • The chromosome of N. farcinica , unlike that of Streptomyces ( 13 , 14 ), has a circular topology ( Fig. 1 ) and encodes 53 tRNA genes, three copies of ribosomal RNA operons, and 5,674 predicted protein-coding sequences. (pnas.org)
  • After 3 days of treatment, analysis revealed that 3,410 genes were differentially expressed in response to at least one of the compounds. (frontiersin.org)
  • FabR represses expression of the two genes, fabA and fabB, required for unsaturated fatty acid synthesis and has been reported to require the presence of an unsaturated thioester (of either acyl carrier protein or CoA) in order to bind the fabA and fabB promoters in vitro. (nih.gov)
  • We have further analyzed these 446 genes by the protein sequence database to list some 96 genes whose products are possibly exposed on the pathogen surface. (oaji.net)
  • The 4,697-bp circular dsDNA genome contains 6 protein -coding genes. (sciensano.be)
  • 0.05), which were similar to their protein expression levels, suggesting that they might be T. spiralis molting-related genes. (biomedcentral.com)
  • Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins. (ymdb.ca)
  • Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. (genome.jp)
  • [12767243] Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. (go.jp)
  • Our results demonstrate that these 7 Coxiella proteins gave a modest sensitivity and specificity for recognizing of Q fever patient sera, suggesting that they are potential serodiagnostic markers for Q fever. (beds.ac.uk)
  • Sera of groups 2 and 3 did not react to the components at the seven locations implying 100% diagnostic specificity of the IgG Western blot assay. (bvsalud.org)
  • N -hexanoyl homoserine lactone (C6-HSL), N -3-hydroxyhexanoyl homoserine lactone (OH-C6-HSL), and N -3-oxohexanoyl homoserine lactone (oxo-C6-HSL) and long-chained AHLs, i.e. (frontiersin.org)
  • N -tetradecanoyl homoserine lactone (C14-HSL), N -3-hydroxytetradecanoyl homoserine lactone (OH-C14-HSL), and N -3-oxotetradecanoyl homoserine lactone (oxo-C14-HSL), on growth of the benthic diatom Seminavis robusta . (frontiersin.org)
  • GO:0004320 (F) oleoyl- [acyl-carrier-protein] hydrolase act. (pku.edu.cn)
  • The research compared and examined the proteins that might participate in PHA metabolism, primary metabolism, and cell's defense systems. (ijbs.com)
  • We report that FabR bound the intact promoter regions of both fabA and fabB in the absence of unsaturated acyl thioesters, but bound the two promoters differently. (nih.gov)
  • However, in contrast to E. coli, gel mobility shift assays indicated that neither E. coli nor V. cholerae FabRs bound the V. cholerae fabB promoter, although both proteins efficiently bound the V. cholerae fabA promoter. (nih.gov)
  • Synthase 2 is mechanistically related to synthase 1 (KAS-I, FabB) containing a number of absolutely conserved catalytic residues in common [2]. (jcvi.org)
  • The evolutionary history of fatty acid synthases are very much intertwined with that of polyketide synthases (PKS). (wikipedia.org)
  • Polyketide synthases use a similar mechanism and homologous domains to produce secondary metabolite lipids. (wikipedia.org)
  • Furthermore, polyketide synthases also exhibit a Type I and Type II organization. (wikipedia.org)
  • Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small mo. (drugbank.ca)
  • [11732905] In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase. (go.jp)
  • 4) enzymes for degradation of misfolded proteins, i.e. (bvsalud.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • 3. The i and j are positions as given in the consensus sequence. (bakerlab.org)
  • We describe several protein sequence statistics designed to evaluate distinctive attributes of residue content and arrangement in primary structure. (oaji.net)
  • The computer program SEQUANA (statistical analysis of protein sequences) calculates all the statistics for any individual protein sequence input and is available for the WINDOWS environment through electronic mail on request to [email protected] (oaji.net)
  • elongation factor P. A poxA mutant has reduced colonization and virulence, possibly due to misregulated expression of proteins encoded by the SPI-1 pathogenicity island [8, 9]. (reninsignaling.com)
  • Biotin is covalently attached to biotin-dependent carboxylase by biotin protein ligase, also known as holocarboxylase synthase in mammals, to form an active holocarboxylase. (genome.jp)
  • Human recombinant protein fragment corresponding to amino acids 78-343 of human OXSM produced in E.coli. (thermofisher.com)
  • Column 2 gives the 3-letter amino acid code, coloured according to physico-chemical type. (ligasite.org)
  • Structural analyses of FadR protein indicated that the hydrophobic interaction amongst the three amino acids (W60, F74 and W75) is critical for its DNA-binding ability by maintaining the configuration of its neighboring two β-sheets. (bvsalud.org)
  • Thus, virulence-related protein secretion is localized in mycobacteria, suggesting new potential therapeutic targets, which are urgently needed. (nih.gov)
  • Despite the identification of several key adherence factors, including pneumococcal surface adhesin A (PsaA), pneumococcal serine repeat protein (PsrP), choline binding proteins (CbpA, CbpE), pilus protein (RrgA), plasminogen- and fibronectin-binding proteins (PfbA and PfbB), pneumococcal adherence and virulence factor A and B (PavA and PavB) [ 8 - 15 ], our understanding of the molecular mechanisms of pneumococcal adherence and invasion remains incomplete. (cdc.gov)
  • Kdo2-lipid IVA 3' secondary acyltransferase [EC:2.3.1. (kegg.jp)
  • Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. (rcsb.org)
  • The molecular and ecological basis of CaCO 3 precipitating (CCP) bacteria has been poorly illuminated. (springer.com)
  • Molecular function: beta-ketoacyl-acyl-carrier-protein synthase III activity. (expasy.org)
  • The analyses of the 309 cell wall proteins provided theoretical molecular mass and p I distributions and determined that 18 proteins are shared with the cell surface-exposed proteome. (biomedcentral.com)
  • Identifying novel seroreactive proteins could be a step towards the development of a fast, specific and safe molecular diagnostic assay instead of traditional serological tests. (beds.ac.uk)
  • Furthermore, we showed CaCO 3 that precipitates earlier in an experiment modifies membrane rigidity of YS11 strain via upregulation of branched chain fatty acid synthesis. (springer.com)
  • This multifunctional protein has 7 catalytic activities and an acyl carrier protein. (abcam.com)
  • To fully address the effect of the genetically-recessive single mutation of W60G on regulatory function of FadR protein, we employed the in vitro and in vivo approaches including EMSA and transcriptional fusion. (nih.gov)
  • List of binding site residues detected in this protein. (ligasite.org)
  • Chain ID's of residues are not mentioned in this page because all chains in the apo -structure refer to the same protein. (ligasite.org)
  • A collection of articles that focus on an array of different scientific topics such as pathways, cancer, transmembrane proteins. (cusabio.com)
  • The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. (mybiosource.com)
  • The C16 acyl-CoA product acts as a substrate for the synthesis of meromycolic acid by FAS-II, whereas the C26 fatty acid constitutes the alpha branch of the final mycolic acid. (wikipedia.org)
  • These proteins were involved in cuticle structural elements, regulation of cuticle synthesis, remodeling and degradation, and hormonal regulation of molting. (biomedcentral.com)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)