Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)

Triclosan

Acyl Carrier Protein

3-Oxoacyl-(Acyl-Carrier-Protein) Reductase

Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)

Pantetheine

Oxidoreductases

Fatty Acid Synthases

Alcohol Oxidoreductases

Fatty Acids

Fatty Acid Synthase, Type II

3-Oxoacyl-(Acyl-Carrier-Protein) Synthase

Bacterial Proteins

Crystallography, X-Ray

Polyketide Synthases

Molecular Sequence Data

Acyl-Carrier Protein S-Malonyltransferase

Transferases (Other Substituted Phosphate Groups)

Acyltransferases

Models, Molecular

Antitubercular Agents

NAD

Coenzyme A

Pantothenic Acid

Escherichia coli

Carbon-Sulfur Ligases

Carrier Proteins

Amino Acid Sequence

Acylation

Thiolester Hydrolases

Malonyl Coenzyme A

Substrate Specificity

Streptomyces

Cerulenin

Sequence Homology, Amino Acid

Saccharopolyspora

Acyl Coenzyme A

Apoproteins

Mycobacterium tuberculosis

Cloning, Molecular

Nitrate Reductases

Multienzyme Complexes

Kinetics

Hydroxymethylglutaryl CoA Reductases

Anthraquinones

Coriandrum

Base Sequence

Acyl-Carrier Protein S-Acetyltransferase

Metabolome

Open Reading Frames

Metabolomics

Oxidoreductase

Beta-ketoacyl-ACP synthase

3-oxoacyl-(acyl-carrier-protein) reductase

3-oxoacyl-(acyl-carrier-protein) reductase (NADH)

Fatty acid synthase

FASN - Wicipedia

List of MeSH codes (D08)

Ketoacyl synthase

List of EC numbers (EC 2)

3-oxoacyl-(acyl-carrier-protein) reductase

NADPH5

• Thus, the two substrates of this enzyme are (3R)-3-hydroxyacyl-[acyl-carrier-protein] and NADP + , whereas its 3 products are 3-oxoacyl-[acyl-carrier-protein] , NADPH , and H + . (wikipedia.org)
• The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). (genecards.org)
• The homotetramer may act as NADPH-dependent quinone reductase. (creative-biogene.com)
• It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (drugbank.ca)
• 3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH. (cbrc.jp)

Putative2

• Putative proteins were identified by 2D SDS-PAGE and LC MS/MS. The most significant match is shown for each protein spot scoring above the MASCOT score significance threshold of 47 (spot numbers designated with an * indicate the best match was below the threshold). (biomedcentral.com)
• However, there are two Ralstonia solanacearum genes, RSc1052 ( fabG1 ) and RSp0359 ( fabG2 ), annotated as encoding putative 3-ketoacyl-ACP reductases. (biomedcentral.com)

Short Chain Dehydro4

• Here we report on the identification and structural characterization of the first NADP-dependent short-chain dehydrogenase/reductase (SDR) involved in inactivation of N-(3-oxo-dodecanoyl)-L-homoserine lactone (3-oxo-C(12)-HSL) and derived from a metagenome library. (proteopedia.org)
• A novel metagenomic short-chain dehydrogenase/reductase attenuates Pseudomonas aeruginosa biofilm formation and virulence on Caenorhabditis elegans. (proteopedia.org)
• CBR4 is a member of the short-chain dehydrogenase/reductase family. (prospecbio.com)
• Both FabG homologues possess the conserved catalytic triad and the N-terminal cofactor binding sequence of the short chain dehydrogenase/reductase (SDR) family. (biomedcentral.com)

Synthase1

• GO:0004315 (F) 3-oxoacyl- [acyl-carrier-protein] synthase a. (pku.edu.cn)

Dehydrogenase3

• 3-ketosteroid-Δ 1 -dehydrogenase. (biomedcentral.com)
• The primary function of hepatic glycerol 3-phosphate dehydrogenase appears to be in gluconeogenesis from glycerol. (biochemj.org)
• PCR products were quantified in Opticon Software® and normalized to endogenous glyceraldehyde 3-phosphate dehydrogenase (GAPDH). (her2signaling.com)

Dehydratase1

• The crystal structure of 3-hydroxydecanoyl-(acyl carrier protein) dehydratase from Vibrio cholerae O1 biovar El Tor str. (csgid.org)

Enoyl2

• Another example is the enzyme enoyl-ACP reductase, which catalyzes the NAD (P) H-dependent reduction of the enoyl-ACP double bond in the last step of the elongation cycle [ 7 ]. (biomedcentral.com)
• GO:0004319 (F) enoyl- [acyl-carrier-protein] reductase (NAD. (pku.edu.cn)

Enzymes6

• The information on proteins involved in different metabolic pathways, particularly the regulation of the enzymes in cells' responses to different organic acids, is invaluable to biosynthesis of PHA biopolymers. (ijbs.com)
• A number of proteins indicate interactions with an as yet unknown host, as indicated by the presence of predicted cell host remodeling enzymes, effector enzymes, hemolysin-like proteins, adhesins, NO reductase, and both type III and type VI secretory complexes. (biomedcentral.com)
• Annotation described in this paper also reveals evidence for several metabolic pathways that have yet to be observed experimentally, including a sulphur oxidation ( sox FCDYZAXB) gene cluster, Calvin cycle enzymes, and proteins involved in nitrogen fixation in other species (including RubisCo, ribulose-phosphate 3-epimerase, and nif gene families, respectively). (biomedcentral.com)
• In addition, the identification of novel proteins associated with P i uptake could be exploited in the removal of P i for water quality improvement, whilst enzymes involved in the catabolism of organophosphorus molecules are of interest in the pharmaceutical and agribiotech industrial sectors. (biomedcentral.com)
• We supply the first evidence that, like other enzymes in the bacterial fatty acid biosynthetic pathway, one bacterium may simultaneously possess two or more 3-oxoacyl-ACP reductase isozymes. (biomedcentral.com)
• 4) enzymes for degradation of misfolded proteins, i.e. (bvsalud.org)

Sequence7

• Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
• p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
• section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
• Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins. (ymdb.ca)
• 119, Last updated, Version 3) XX DE Rhodococcus jostii RHA1 plasmid pRHL3, complete sequence. (univ-lyon1.fr)
• Sequence related families of genes and proteins are common in bacterial genomes. (beds.ac.uk)
• HQ584991 Polytomella parva strain SAG 63-3 18S ribosomal RNA gene, partial sequence. (uni-goettingen.de)

Genes2

• Proteins whose genes are observed to be correlated in expression, across a large number of experiments. (string-db.org)
• Nobile CJ, Mitchell AP: Regulation 3-oxoacyl-(acyl-carrier-protein) reductase of cell-surface genes and biofilm formation by the C-albicans transcription factor Bcr1p. (pparsignaling.com)

NADH4

• Other names in common use include 3-oxoacyl-[acyl carrier protein] (reduced nicotinamide adenine, dinucleotide) reductase, and 3-oxoacyl-[acyl-carrier-protein] reductase (NADH). (wikipedia.org)
• The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. (abcam.com)
• The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). (genecards.org)
• CBR4 formation of a heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity for o- and p-quinones. (prospecbio.com)

Oleoyl1

• GO:0004320 (F) oleoyl- [acyl-carrier-protein] hydrolase act. (pku.edu.cn)

Alkyl1

• Alkyl hydroperoxide reductase, encoded by ahpC, is a member of the peroxiredoxin enzyme family. (bcl2-receptor.com)

Gene6

• section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. (uniprot.org)
• p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
• CBR4 (Carbonyl Reductase 4) is a Protein Coding gene. (genecards.org)
• The presence of families and superfamilies of proteins suggest a history of gene duplication and divergence during evolution. (beds.ac.uk)
• Protein families seem likely to have arisen during evolution by gene duplication and divergence where the gene copies that have been retained are the variants that have led to distinct bacterial physiologies and taxa. (beds.ac.uk)
• However in 1970, Ohno [ 3 ] introduced the idea of gene duplication as an important form of genetic variation, a process that would go beyond gradualism and would permit quantum changes. (beds.ac.uk)

Yeast4

• Global analysis of protein localization in budding yeast. (ymdb.ca)
• No yeast two-hybrid interactions found for this protein. (yeastrc.org)
• NAD + , NADP + , yeast extract, and molecular-weight marker-proteins for gel filtration were from Oriental Yeast (Tokyo, Japan). (hindawi.com)
• Granger Kinase Inhibitor Library cell assay BL, Flenniken ML, Davis DA, Mitchell AP, Cutler JE: Yeast wall protein 1 of Candida albicans. (pparsignaling.com)

UniProt1

• p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)

Coenzyme1

• Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases. (genome.jp)

Organism1

• This, along with its ability to reduce perchlorate (a teratogenic contaminant introduced into the environment by man) and inquiry into its use in biocells [ 3 ] has led to interest in using this organism for bioremediation and energy production. (biomedcentral.com)

Oxidoreductase1

• The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP + oxidoreductase . (wikipedia.org)

Biosynthesis3

• A number of proteins were found to be induced in R. eutropha by using 1D-PAGE and nano-liquid chromatography tandem MS/MS. With the proteins being up-regulated, a dramatic change occurred in the induction of PHA metabolism, including fatty acid biosynthesis for acetate, β-oxidation for propionate and both for levulinic acid. (ijbs.com)
• The organic acids induced several proteins involved in amino acid biosynthesis, purine and pyrimidine biosynthesis, and cofactor biosynthesis in R. eutropha , but the regulations had a great variation. (ijbs.com)
• During acetate metabolism proteins involved in the lipid metabolism and hexosamine biosynthesis were over-expressed in the acetate medium, while proteins involved in TCA cycle, pentose phosphate cycle and purine metabolism were down-regulated. (ijbs.com)

Specificity2

• A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS. (bvsalud.org)
• Sera of groups 2 and 3 did not react to the components at the seven locations implying 100% diagnostic specificity of the IgG Western blot assay. (bvsalud.org)

Enzyme2

• The AHL signaling molecules are subject to inactivation mainly by hydrolases (Enzyme Commission class number EC 3) (i.e. (proteopedia.org)
• FabG is the only known enzyme that catalyzes reduction of the 3-ketoacyl-ACP intermediates of bacterial fatty acid synthetic pathways. (biomedcentral.com)

Genome3

• Destruction of the insect gut tissue occurs during infection.Analysis of the proteins encoded by the genome indicated a number of potential virulence factors, although a type III secretion system was not found. (up.ac.za)
• Genome encoded protein families, their size and functional composition, reflect metabolic potentials of the organisms they are found in. (beds.ac.uk)
• To investigate further the contribution of the adenovirus type 5 (Ad5) E1B 55-kDa protein to genome replication, viral DNA accumulation was examined in primary human fibroblasts and epithelial cells infected with Ad5 or the E1B 55-kDa-null mutant Hr6. (gp120inhibitor.com)

Substrates1

• Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates. (termsciences.fr)

Hypothetical protein1

• X-ray diffraction data for the 2.35 Angstrom Crystal Structure of Conserved Hypothetical Protein from Toxoplasma gondii ME49. (proteindiffraction.org)

Catalytic1

• This multifunctional protein has 7 catalytic activities and an acyl carrier protein. (abcam.com)

Strain2

• In addition, our study reports the expression of several parasite proteins in clinical ring stages that have never been reported in the ring stages of the laboratory-cultivated parasite strain. (micrornasynthesis.com)
• In vitro assays demonstrate that both proteins restore fatty acid synthetic ability to extracts of the E. coli strain. (biomedcentral.com)

Regulation2

• The responses of the cells to the organic acids, such as regulation of proteins, can reveal the metabolic activities and mechanisms in detoxification and utilization of different organic acids by the microbial cells [ 10 ]. (ijbs.com)
• However, it also demonstrates some characteristics of desiccation stress, such as the regulation of fatty acids and increased abundance of rehydrin in the 3% P i culture. (biomedcentral.com)

UniProtKB1

• Search proteins in UniProtKB for this molecule. (uniprot.org)

Glycerol1

• The imidazole in the eluent was removed using a Centrifuge Biomax-5 column (Millipore, Billerica, MA, USA), and the AirR protein solution was supplemented with 30% glycerol and stored at −80°C until use. (hivprotease-signal.com)

Annotation2

• p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
• be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)

Metabolism3

• Deletion of the 2-acyl-glycerophosphoethanolamine cycle improve glucose metabolism in Escherichia coli strains employed for overproduction of aromatic compounds. (nih.gov)
• The research compared and examined the proteins that might participate in PHA metabolism, primary metabolism, and cell's defense systems. (ijbs.com)
• Digital subtraction analysis of preoperative [F-18]2-fluoro-2deoxy-D-glucose positron emission tomographic scan: and positron emission tomographic scans obtained after 3 months of stimulation;showed Geneticin decreased frontal metabolism during stimulation. (gp120inhibitor.com)

Biochemical1

• Using acetyl-CoA and malonyl-CoA as the initiating substrate and building block, respectively, these organisms share a common set of biochemical reactions to extend fatty acyl chains by two carbon atoms per cycle [ 1 - 3 ]. (biomedcentral.com)

Family5

• Belongs to the short-chain dehydrogenases/reductases (SDR) family. (abcam.com)
• 2003. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. (scbt.com)
• Both similarities and differences were detected in the protein family memberships, with more similarities being detected among the more closely related organisms. (beds.ac.uk)
• Protein family memberships reflected known metabolic characteristics of the organisms. (beds.ac.uk)
• This HMM represents a small, very well conserved family of proteins closely related to the FabG family, TIGR01830, and possibly equal in function. (jcvi.org)