An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.
Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).
A family of gram-negative, aerobic, non-spore forming rods or cocci. Well known genera include ACHROMOBACTER; ALCALIGENES; and BORDETELLA.
Derivatives of propionic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxyethane structure.
An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1.7.
Compounds containing the -SH radical.
A long-chain fatty acid ester of carnitine which facilitates the transfer of long-chain fatty acids from cytoplasm into mitochondria during the oxidation of fatty acids.
Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is formed.
'Allyl compounds' are organic substances that contain the allyl group (CH2=CH-CH2-) as a functional component, which can be found in various forms such as allyl alcohol, allyl chloride, and allyl esters.
Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS.
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.

Specific adhesion of vesicles monitored by scanning force microscopy and quartz crystal microbalance. (1/62)

The specific adhesion of unilamellar vesicles with an average diameter of 100 nm on functionalized surfaces mediated by molecular recognition was investigated in detail. Two complementary techniques, scanning force microscopy (SFM) and quartz crystal microbalance (QCM) were used to study adhesion of liposomes consisting of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine and varying concentrations of N-((6-biotinoyl)amino)hexanoyl)-1, 2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (biotin-X-DHPE). Monitoring the adhesion of the receptor-doped vesicles to avidin-coated gold surfaces by QCM (f(0) = 5 MHz) revealed an increased shift in resonance frequency with increasing biotin concentration up to 10 mol% biotin-X-DHPE. To address the question of how the morphology of the liposomes changes upon adhesion and how that contributes to the resonator's frequency response, we performed a detailed analysis of the liposome morphology by SFM. We found that, with increasing biotin-concentration, the height of the liposomes decreases considerably up to the point where vesicle rupture occurs. Thus, we conclude that the unexpected high frequency shifts of the quartz crystal (>500 Hz) can be attributed to a firm attachment of the spread bilayers, in which the number of contacts is responsible for the signal. These findings are compared with one of our recent studies on cell adhesion monitored by QCM.  (+info)

Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma. (2/62)

Because bradykinin (BK) appears to have cardioprotective effects ranging from improved hemodynamics to antiproliferative effects, inhibition of BK-degrading enzymes should potentiate such actions. The purpose of this study was to find out which enzymes are responsible for the degradation of BK in human plasma. Human plasma from healthy donors (n = 10) was incubated with BK in the presence or absence of specific enzyme inhibitors. At high (micromolar) concentrations, BK was mostly (>90%) degraded by carboxypeptidase N (CPN)-like activity. In contrast, at low (nanomolar) substrate concentrations, at which the velocity of the catalytic reaction is equivalent to that under physiological conditions, BK was mostly (>90%) converted into an inactive metabolite, BK-(1-7), by angiotensin-converting enzyme (ACE). BK-(1-7) was further converted by ACE into BK-(1-5), with accumulation of this active peptide. A minor fraction (<10%) of the BK was converted into another active metabolite, BK-(1-8), by CPN-like activity. The present study shows that the most critical step in plasma kinin metabolism, i.e., inactivation of BK, is mediated by ACE. Thus inhibition of plasma ACE activity would be cardioprotective by elevating the concentration of BK in the circulation.  (+info)

Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic rats. (3/62)

1. The successive effects of the angiotensin-converting enzyme inhibitor captopril (CAP, 2 mg kg(-1)+1 mg kg(-1) 30 min(-1) infusion) and the neutral endopeptidase 24-11 inhibitor retrothiorphan (RT, 25 mg kg(-1)+12.5 mg kg(-1) 30 min(-1) infusion) were studied on femoral vascular conductance (FVC) in streptozotocin-induced diabetic (STZ-SD) and control Sprague-Dawley (C-SD) rats. The role of the kinin-nitric oxide (NO) pathway was assessed by (1) using pre-treatments: a bradykinin (BK) B2 receptor antagonist (Hoe-140, 300 microg kg(-1)), a NO-synthase inhibitor (N(omega)-nitro-L-arginine methyl ester, L-NAME, 10 mg kg(-1)), a kininase I inhibitor (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, MGTA, 10 mg kg(-1)+20 mg kg(-1) 20 min(-1) infusion) and (2) comparing the effects in STZ-induced diabetic (STZ-BN) and control Brown-Norway kininogen-deficient (C-BN) rats. 2. In C-SDs, CAP and CAP+RT increased FVC similarly. In STZ-SDs, FVC and FBF were decreased compared to C-SDs. CAP+RT increased them more effectively than CAP alone. 3. In both C-SDs and STZ-SDs, the femoral bed vasodilatation elicited by CAP was inhibited by Hoe-140 and L-NAME. The FVC increase elicited by CAP+RT was not significantly reduced by Hoe-140 but was inhibited by L-NAME and Hoe-140+MGTA. 4. In C-BNs, the vasodilatator responses to CAP and CAP+RT were abolished and highly reduced, respectively. In STZ-BNs, these responses were abolished. 5. These results show that in STZ-SDs, CAP+RT improve FBF and FVC more effectively than CAP alone. These effects are linked to an increased activation of the kinin-NO pathway. BK could lead to NO production by BK B2 receptor activation and another pathway in which kininase I may be involved.  (+info)

Persistent activation of GABA(A) receptor/Cl(-) channels by astrocyte-derived GABA in cultured embryonic rat hippocampal neurons. (4/62)

Whole cell patch-clamp recordings using Cl(-)-filled pipettes revealed more negative levels of baseline current and associated current variance in embryonic rat hippocampal neurons co-cultured on a monolayer of astrocytes than those cultured on poly-D-lysine. These effects were mimicked by culturing neurons on poly-D-lysine in astrocyte-conditioned medium (ACM). The baseline current and variance decreased immediately in all cells after either local perfusion with saline or exposure to bicuculline, an antagonist of GABA at GABA(A) receptor/Cl(-) channels. Baseline current and variance in all cells reached a nadir at approximately 0 mV, the calculated equilibrium potential for Cl(-). Perfusion of ACM rapidly induced a sustained current in neurons, which also reversed polarity at approximately 0 mV. Bicuculline attenuated or eliminated the ACM-induced current at a concentration that completely blocked micromolar GABA-induced current. Quantitative analyses of spontaneously occurring fluctuations superimposed on the ACM-induced current revealed estimated unitary properties of the underlying channel activity similar to those calculated for GABA's activation of GABA(A) receptor/Cl(-) channels. Bicuculline-sensitive synaptic-like transients, which reversed at approximately 0 mV, were also detected in neurons cultured in ACM, and these were immediately eliminated along with the negative baseline current and superimposed current fluctuations by perfusion. Furthermore bicuculline-sensitive synaptic-like transients were rapidly and reversibly triggered when ACM was acutely applied. ACM induced an increase in cytoplasmic Ca(2+) in cultured embryonic hippocampal neurons that was completely blocked by bicuculline and strychnine. We conclude that astrocytes release diffusible substances, most likely GABA, that persistently activate GABA(A) receptor/Cl(-) channels in co-cultured neurons.  (+info)

Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages. (5/62)

This is the first report on the biosynthesis of a hitherto unknown, sulfur-containing polyester and also the first report on a bacterial polymer containing sulfur in the backbone. The Gram-negative polyhydroxyalkanoate (PHA)-accumulating bacterium Ralstonia eutropha synthesized a copolymer of 3-hydroxybutyrate and 3-mercaptopropionate, poly(3HB-co-3MP), when 3-mercaptopropionic acid or 3,3'-thiodipropionic acid was provided as carbon source in addition to fructose or gluconic acid under nitrogen-limited growth conditions. The peculiarity of this polymer was the occurrence of thioester linkages derived from the thiol groups of 3MP and the carboxyl groups of 3MP or 3HB, respectively, which occurred in addition to the common oxoester bonds of PHAs. Depending on the cultivation conditions and the feeding regime, poly(3HB-co-3MP) contributed up to 19% of the cellular dry weight, with a molar fraction of 3MP of up to 43%. The chemical structure of poly(3HB-co-3MP) was confirmed by GC/MS, IR spectroscopy, (1)H- and (13)C-NMR spectroscopy, and elemental sulfur analysis. The identification of this novel biopolymer reveals a new quality regarding the substrate range of PHA synthases and their capability for the synthesis of technically interesting polymers.  (+info)

Plasticity of rat central inhibitory synapses through GABA metabolism. (6/62)

1. The production of the central inhibitory transmitter GABA (gamma-aminobutyric acid) varies in response to different patterns of activity. It therefore seems possible that GABA metabolism can determine inhibitory synaptic strength and that presynaptic GABA content is a regulated parameter for synaptic plasticity. 2. We altered presynaptic GABA metabolism in cultured rat hippocampal slices using pharmacological tools. Degradation of GABA by GABA-transaminase (GABA-T) was blocked by gamma-vinyl-GABA (GVG) and synthesis of GABA through glutamate decarboxylase (GAD) was suppressed with 3-mercaptopropionic acid (MPA). We measured miniature GABAergic postsynaptic currents (mIPSCs) in CA3 pyramidal cells using the whole-cell patch clamp technique. 3. Elevated intra-synaptic GABA levels after block of GABA-T resulted in increased mIPSC amplitude and frequency. In addition, tonic GABAergic background noise was enhanced by GVG. Electron micrographs from inhibitory synapses identified by immunogold staining for GABA confirmed the enhanced GABA content but revealed no further morphological alterations. 4. The suppression of GABA synthesis by MPA had opposite functional consequences: mIPSC amplitude and frequency decreased and current noise was reduced compared with control. However, we were unable to demonstrate the decreased GABA content in biochemical analyses of whole slices or in electron micrographs. 5. We conclude that the transmitter content of GABAergic vesicles is variable and that postsynaptic receptors are usually not saturated, leaving room for up-regulation of inhibitory synaptic strength. Our data reveal a new mechanism of plasticity at central inhibitory synapses and provide a rationale for the activity-dependent regulation of GABA synthesis in mammals.  (+info)

Chiral separation by electrokinetic capillary chromatography using newly synthesized linear polymers containing L-amino acid moieties. (7/62)

Chiral linear polymers were prepared by the thermal polymerization of N-acryloyl-L-valine and N-acryloyl-L-alanine derivatives using 3-mercaptopropionic acid (3-MPA) as a radical transfer agent. C-Terminal groups of the derivatives were methyl and tert-butyl esters later removed, and N-methylamide moieties. The N'-methylamide derivative of N-acryloyl-L-valine was copolymerized with methyl ester at a molar mixing ratio of 1:1. The ester groups were removed to provide anionic linear polymers terminated with carboxylic acid of the amino acid residue. The polymers are thus shown to function as pesudostationary phases that separate enantiomeric solutes in electrokinetic capillary chromatography (EKC). Racemic 3,5-dinitrobenzoylamino isopropyl esters were separated with the polymer derived from N-acryloyl-L-valine esters and with the copolymer from N-acryloyl-L-valine methyl ester and N-acryloyl-L-valine N'-methylamide at pH 7.0. These separations could not be observed at pH 9.0 in migrating solutions containing anionic linear polymers. This pH dependence can be discussed from the standpoint of the microscopic hydrophobicity of the polymers, as assessed from the fluorescence of pyrene adsorbed onto the polymers in water.  (+info)

Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis. (8/62)

Arginine carboxypeptidase was isolated from the cytoplasm of Porphyromonas gingivalis 381 and purified by DEAE-Sephacel column chromatography, followed by high-performance liquid chromatography on DEAE-5PW and TSK G2000SW(XL). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified enzyme revealed the presence of three major bands at 42, 33, and 32 kDa with identical N-terminal sequences. By Western blotting analysis and immunoelectron microscopy, the arginine carboxypeptidase was found to be widely distributed in the cytoplasm and on the surface of the outer membrane. The open reading frame corresponding to the N-terminal amino acids of the arginine carboxypeptidase was detected by a search of the sequence of the P. gingivalis W83 genome. This sequence showed homology with mammalian carboxypeptidases (M, N, and E/H) and included a zinc-binding region signature, suggesting that the enzyme is a member of the zinc carboxypeptidase family. The purified enzyme was inhibited by EGTA, o-phenanthroline, DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, and some metal ions, such as Cu(2+), Zn(2+), and Cd(2+). On the other hand, Co(2+) activated the enzyme. The enzyme released arginine and/or lysine from biologically active peptides containing these amino acids at the C terminus but did not cleave substrates when proline was present at the penultimate position. These results indicate that the arginine carboxypeptidase produced by P. gingivalis is an exo type of metallocarboxypeptidase. This enzyme may function to release arginine in collaboration with an arginine aminopeptidase, e.g., Arg-gingipain, to obtain specific amino acids from host tissues during the growth of P. gingivalis.  (+info)

3-Mercaptopropionic acid is an organic compound with the formula CH3SHCO2H. It is a colorless liquid that is used as a building block in the synthesis of various pharmaceuticals and industrial chemicals. The compound is characterized by the presence of a thiol (also called a mercaptan) group, which consists of a sulfur atom bonded to a hydrogen atom (-SH). This functional group makes 3-mercaptopropionic acid a strong smelling, acidic compound that can react with various substances.

In the medical field, 3-mercaptopropionic acid is not used directly as a drug or therapeutic agent. However, it may be employed in the synthesis of certain medications or as a reagent in diagnostic tests. For instance, it has been used to prepare radiopharmaceuticals for imaging and detecting brain tumors.

It is important to note that 3-mercaptopropionic acid can have adverse health effects if not handled properly. It can cause skin and eye irritation, and prolonged exposure may lead to more severe health issues. Therefore, appropriate safety measures should be taken when working with this compound in a laboratory or industrial setting.

Myoclonus is a medical term that describes a quick, involuntary jerking muscle spasm. These spasms can happen once or repeat in a series, and they can range from mild to severe in nature. Myoclonus can affect any muscle in the body and can be caused by several different conditions, including certain neurological disorders, injuries, or diseases. In some cases, myoclonus may occur without an identifiable cause.

There are various types of myoclonus, classified based on their underlying causes, patterns of occurrence, and associated symptoms. Some common forms include:

1. Action myoclonus: Occurs during voluntary muscle movements
2. Stimulus-sensitive myoclonus: Triggered by external or internal stimuli, such as touch, sound, or light
3. Physiological myoclonus: Normal muscle jerks that occur during sleep onset (hypnic jerks) or during sleep (nocturnal myoclonus)
4. Reflex myoclonus: Result of a reflex arc activation due to a peripheral nerve stimulation
5. Epileptic myoclonus: Part of an epilepsy syndrome, often involving the brainstem or cortex
6. Symptomatic myoclonus: Occurs as a result of an underlying medical condition, such as metabolic disorders, infections, or neurodegenerative diseases

Treatment for myoclonus depends on the specific type and underlying cause. Medications, physical therapy, or lifestyle modifications may be recommended to help manage symptoms and improve quality of life.

Alcaligenaceae is a family of gram-negative, aerobic or facultatively anaerobic bacteria that are commonly found in soil, water, and the gastrointestinal tracts of animals. Members of this family are typically oxidase-positive and catalase-positive, and they can use a variety of organic compounds as carbon sources. Some species of Alcaligenaceae have been associated with human disease, including respiratory infections, urinary tract infections, and bacteremia. However, these infections are relatively rare, and the majority of Alcaligenaceae species are not considered to be significant pathogens.

Propionates, in a medical context, most commonly refer to a group of medications that are used as topical creams or gels to treat fungal infections of the skin. Propionic acid and its salts, such as propionate, are the active ingredients in these medications. They work by inhibiting the growth of fungi, which causes the infection. Common examples of propionate-containing medications include creams used to treat athlete's foot, ringworm, and jock itch.

It is important to note that there are many different types of medications and compounds that contain the word "propionate" in their name, as it refers to a specific chemical structure. However, in a medical context, it most commonly refers to antifungal creams or gels.

Carnitine O-acetyltransferase (COAT) is an enzyme that plays a crucial role in the transport and metabolism of fatty acids within cells. It is also known as carnitine palmitoyltransferase I (CPT I).

The primary function of COAT is to catalyze the transfer of an acetyl group from acetyl-CoA to carnitine, forming acetylcarnitine and free CoA. This reaction is essential for the entry of long-chain fatty acids into the mitochondrial matrix, where they undergo beta-oxidation to produce energy in the form of ATP.

COAT is located on the outer membrane of the mitochondria and functions as a rate-limiting enzyme in fatty acid oxidation. Its activity can be inhibited by malonyl-CoA, which is an intermediate in fatty acid synthesis. This inhibition helps regulate the balance between fatty acid oxidation and synthesis, ensuring that cells have enough energy while preventing excessive accumulation of lipids.

Deficiencies or mutations in COAT can lead to various metabolic disorders, such as carnitine palmitoyltransferase I deficiency (CPT I deficiency), which may cause symptoms like muscle weakness, hypoglycemia, and cardiomyopathy. Proper diagnosis and management of these conditions often involve dietary modifications, supplementation with carnitine, and avoidance of fasting to prevent metabolic crises.

Sulfhydryl compounds, also known as thiol compounds, are organic compounds that contain a functional group consisting of a sulfur atom bonded to a hydrogen atom (-SH). This functional group is also called a sulfhydryl group. Sulfhydryl compounds can be found in various biological systems and play important roles in maintaining the structure and function of proteins, enzymes, and other biomolecules. They can also act as antioxidants and help protect cells from damage caused by reactive oxygen species. Examples of sulfhydryl compounds include cysteine, glutathione, and coenzyme A.

Palmitoylcarnitine is a type of acylcarnitine, which is an ester formed from carnitine and a fatty acid. Specifically, palmitoylcarnitine consists of the long-chain fatty acid palmitate (a 16-carbon saturated fatty acid) linked to carnitine through an ester bond.

In the human body, palmitoylcarnitine plays a crucial role in the transport and metabolism of long-chain fatty acids within mitochondria, the energy-producing organelles found in cells. The process involves converting palmitate into palmitoylcarnitine by an enzyme called carnitine palmitoyltransferase I (CPT-I) in the outer mitochondrial membrane. Palmitoylcarnitine is then transported across the inner mitochondrial membrane via a specific transporter, where it is converted back to palmitate by another enzyme called carnitine palmitoyltransferase II (CPT-II). The palmitate can then undergo beta-oxidation, a process that generates energy in the form of ATP.

Abnormal levels of palmitoylcarnitine in blood or other bodily fluids may indicate an underlying metabolic disorder, such as defects in fatty acid oxidation or carnitine transport. These conditions can lead to various symptoms, including muscle weakness, cardiomyopathy, and developmental delays.

Acetyl-CoA C-acyltransferase is also known as acyl-CoA synthetase or thiokinase. It is an enzyme that plays a crucial role in the metabolism of fatty acids. Specifically, it catalyzes the formation of an acyl-CoA molecule from a free fatty acid and coenzyme A (CoA).

The reaction catalyzed by Acetyl-CoA C-acyltransferase is as follows:

R-COOH + CoA-SH + ATP → R-CO-SCoA + AMP + PPi

where R-COOH represents a free fatty acid, and R-CO-SCoA is an acyl-CoA molecule.

This enzyme exists in several forms, each specific to different types of fatty acids. Acetyl-CoA C-acyltransferase is essential for the metabolism of fatty acids because it activates them for further breakdown in the cell through a process called beta-oxidation. This enzyme is found in various tissues, including the liver, muscle, and adipose tissue.

Allyl compounds are organic compounds that contain the allyl group, which is a functional group with the formula CH2=CH-CH2-. The allyl group consists of a methylene bridge (CH2-) flanked by a carbon-carbon double bond (-CH=). Allyl compounds can be derived from allyl alcohol, allyl chloride, or other allyl halides and can participate in various chemical reactions due to the reactivity of the double bond. They are used in organic synthesis, pharmaceuticals, and agrochemicals.

Acyl-CoA dehydrogenases are a group of enzymes that play a crucial role in the body's energy production process. They are responsible for catalyzing the oxidation of various fatty acids, which are broken down into smaller molecules called acyl-CoAs in the body.

More specifically, acyl-CoA dehydrogenases facilitate the removal of electrons from the acyl-CoA molecules, which are then transferred to coenzyme Q10 and eventually to the electron transport chain. This process generates energy in the form of ATP, which is used by cells throughout the body for various functions.

There are several different types of acyl-CoA dehydrogenases, each responsible for oxidizing a specific type of acyl-CoA molecule. These include:

* Very long-chain acyl-CoA dehydrogenase (VLCAD), which oxidizes acyl-CoAs with 12 to 20 carbon atoms
* Long-chain acyl-CoA dehydrogenase (LCAD), which oxidizes acyl-CoAs with 14 to 20 carbon atoms
* Medium-chain acyl-CoA dehydrogenase (MCAD), which oxidizes acyl-CoAs with 6 to 12 carbon atoms
* Short-chain acyl-CoA dehydrogenase (SCAD), which oxidizes acyl-CoAs with 4 to 8 carbon atoms
* Isovaleryl-CoA dehydrogenase, which oxidizes isovaleryl-CoA, a specific type of branched-chain acyl-CoA molecule

Deficiencies in these enzymes can lead to various metabolic disorders, such as medium-chain acyl-CoA dehydrogenase deficiency (MCADD) or long-chain acyl-CoA dehydrogenase deficiency (LCADD), which can cause symptoms such as hypoglycemia, muscle weakness, and developmental delays.

Pyridoxine is the chemical name for Vitamin B6. According to the medical definition, Pyridoxine is a water-soluble vitamin that is part of the B-vitamin complex and is essential for the metabolism of proteins, carbohydrates, and fats. It plays a vital role in the regulation of homocysteine levels in the body, the formation of neurotransmitters such as serotonin and dopamine, and the synthesis of hemoglobin.

Pyridoxine can be found naturally in various foods, including whole grains, legumes, vegetables, nuts, seeds, meat, poultry, and fish. It is also available as a dietary supplement and may be prescribed by healthcare providers to treat or prevent certain medical conditions, such as vitamin B6 deficiency, anemia, seizures, and carpal tunnel syndrome.

Like other water-soluble vitamins, Pyridoxine cannot be stored in the body and must be replenished regularly through diet or supplementation. Excessive intake of Pyridoxine can lead to toxicity symptoms such as nerve damage, skin lesions, and light sensitivity.

A seizure is an uncontrolled, abnormal firing of neurons (brain cells) that can cause various symptoms such as convulsions, loss of consciousness, altered awareness, or changes in behavior. Seizures can be caused by a variety of factors including epilepsy, brain injury, infection, toxic substances, or genetic disorders. They can also occur without any identifiable cause, known as idiopathic seizures. Seizures are a medical emergency and require immediate attention.

"Papio" is a term used in the field of primatology, specifically for a genus of Old World monkeys known as baboons. It's not typically used in human or medical contexts. Baboons are large monkeys with robust bodies and distinctive dog-like faces. They are native to various parts of Africa and are known for their complex social structures and behaviors.

Allylglycine Thiolactic acid (2-mercaptopropionic acid) Horton, R. W; Meldrum, B. S (1973). "Seizures induced by allylglycine, ... It is a bifunctional molecule, containing both carboxylic acid and thiol groups. It is a colorless oil. It is derived from the ... and different modes of inhibition of cerebral glutamic acid decarboxylase". British Journal of Pharmacology. 49 (1): 52-63. doi ... Propionic acids, All stub articles, Organic compound stubs). ... addition of hydrogen sulfide to acrylic acid. It is competitive ...
Alpha-Amino acids, Convulsants, Glutamate decarboxylase inhibitors, Enzyme inhibitors, Allyl compounds, All stub articles, ... 49 (6): 1181-3. doi:10.1016/0031-9384(91)90348-R. PMID 1654571. S2CID 10506822. v t e v t e (Chemical articles with multiple ... 4 (3): 263-6. doi:10.1111/j.1440-1681.1977.tb02623.x. PMID 891041. S2CID 25088608. Abshire VM, Hankins KD, Roehr KE, DiMicco JA ... 3-Mercaptopropionic acid Piepho, R. W; Friedman, A. H (1977). "Chronopharmacology of Strychnine and Allylglycine in the Mouse ...
... is the organosulfur compound with the formula HSCH2CO2H. The molecule contains both carboxylic acid and thiol ... It is structurally related to lactic acid by the interchange of SH for OH. It is a colorless oil. Thiolactic acid was once ... Instead of using the acid itself, its salts are used. It is now mainly used for depilation. Hydroxybutyric acid 3- ... Mercaptopropionic acid T. Clausen (2006). "Hair Preparations". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ...
AMPA Domoic acid Kainic acid NMDA Quinolinic acid Quisqualic acid Tetrazolylglycine Acetylcholine receptor agonists are drugs ... For example, kainic acid can lead to status epilepticus in animals as it is a cyclic analog of l-glutamate and an agonist for ... "Kainic Acid - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-01-15. "GABA-A Receptor Antagonists - ... 610 (1-3): 1-11. doi:10.1016/j.ejphar.2009.03.025. PMID 19292981. Rubio C, Rubio-Osornio M, Retana-Márquez S, Verónica Custodio ...
However the strategy is limited by the fact that it requires a cysteine residue at N-terminus, an amino acid residue that is ... O-Linked glycans are formed by a linkage between an amino acid hydroxyl side chain (usually from serine or threonine) with the ... The scale of this technique can be an advantage for creating libraries for screening by using less amounts of glycoamino acids ... Shao N.; Xue J.; Guo Z. W. (2003). "Chemical synthesis of CD52 glycopeptides containing the acid-labile fucosyl linkage". ...
These in turn are produced from acrylic acid via the 3-mercaptopropionic acid: Ring-closure of the thiol-amide is typically ... A 3:1 mixture of CMIT:MIT is sold as Kathon. Kathon is supplied as a concentrated stock solution containing from 1.5 to 15% of ... 4,5-Dichloro-2-n-octyl-4-isothiazolino-3-one (DCOI or Sea-Nine 211) is used especially as an antifouling agent, i.e. paint for ... 367 (2-3): 573-85. Bibcode:2006ScTEn.367..573B. doi:10.1016/j.scitotenv.2006.01.028. PMID 16545431. Rohm and Haas, Toxicology ...
Methylphosphonic acid Mycophenolic acid, an immunosuppressant drug 4-Nonanoylmorpholine or morpholide pelargonic acid Marriage ... for assessing motivations Medroxyprogesterone acetate 3-Mercaptopropionic acid Methiopropamine, (N-methyl-1-(thiophen-2-yl) ...
... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ... muramic acids MeSH D02.241.081.844.562 - neuraminic acids MeSH D02.241.081.844.562.668 - sialic acids MeSH D02.241.081.844. ...
... acrylic acid) copolymers polyelectrolyte, poly(methacrylic acid) (PMAA) etc. Gold nanoclusters have been synthesized with ... Poly(methacrylic acid)-stabilized nanoclusters have an excellent high quantum yield and can be transferred to other scaffolds ... Look up mercaptoundecanoic acid or microgel in Wiktionary, the free dictionary. Dendrimers. Dendrimers are used as templates to ... The green-emitting gold nanoclusters can be synthesized by adding mercaptoundecanoic acid (MUA) into the prepared small gold ...
2-mercaptopropionic acid) 3-Mercaptopropionic acid (3-MPA) This set index page lists chemical structure articles associated ... The molecular formula C3H6O2S (molar mass: 106.14 g/mol, exact mass: 106.0089 u) may refer to: Thiolactic acid ( ...
In step 3, S1 was turned off, S2 was turned on, and then TENG2 was triggered to supply high-voltage output for TENG1. The ... 3. With the use of four supporting springs, a harmonic resonator-based TENG has been fabricated based on the resonance-induced ... The 3-D TENG is designed for harvesting ambient vibration energy, especially at low frequencies, under a range of conditions in ... The maximum voltage generated in the nanowire can be calculated using the following equation: V max = ± 3 4 ( κ 0 + κ ) [ e 33 ...
It has the amino acid sequence Mpa-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Mpa = β-mercaptopropionic acid), and is an analogue of ... oxytocin wherein the leading cysteine is replaced with β-mercaptopropionic acid. Labour was induced or stimulated after random ... 301-. ISBN 978-3-88763-075-1. (CS1 Polish-language sources (pl), Articles with short description, Short description matches ... 389-. ISBN 978-1-60750-345-3. Tom K. A. B. Eskes; Mieczyslaw Finster (22 October 2013). Drug Therapy During Pregnancy. Elsevier ...
Another potential use involves capped single-crystal ZnO nanowires with CdSe quantum dots, immersed in mercaptopropionic acid ... Aromatic self-assembled monolayers (SAMs) (such as 4-nitrobenzoic acid) can be used to improve the band alignment at electrodes ... Antibodies, streptavidin, peptides, DNA, nucleic acid aptamers, or small-molecule ligands can be used to target quantum dots to ... "Quantum dots as donors in fluorescence resonance energy transfer for the bioanalysis of nucleic acids, proteins, and other ...
Allylglycine Thiolactic acid (2-mercaptopropionic acid) Horton, R. W; Meldrum, B. S (1973). "Seizures induced by allylglycine, ... It is a bifunctional molecule, containing both carboxylic acid and thiol groups. It is a colorless oil. It is derived from the ... and different modes of inhibition of cerebral glutamic acid decarboxylase". British Journal of Pharmacology. 49 (1): 52-63. doi ... Propionic acids, All stub articles, Organic compound stubs). ... addition of hydrogen sulfide to acrylic acid. It is competitive ...
... coefficient of the test material 3-mercaptopropionic acid, has been chosen as a key study. The octanol-water partition ...
3-Mercaptopropionic acid was tested for acute toxicity towards Daphnia according to OECD 202, Part I. In order to investigate ... 3-Mercaptopropionic acid was tested for acute toxicity towards fish according to OECD-Test Guideline 203. In order to ... A full set of short-term toxicity data is available for 3-MPA, but no long-term ecotoxicity data. However, before proposing ... The influence of the test item 3-mercaptopropionic acid on the activity of activated sludge was evaluated by measuring the ...
Complexes of palladium(II) and platinum(II) with mercaptoacetic and 3-mercaptopropionic acids. M. Chandrasekharan, M. ... View more info for Complexes of palladium(II) and platinum(II) with mercaptoacetic and 3-mercaptopropionic acids ...
Acetic acid, mercapto-, monosodium salt. Molecular and structural information. Molecular formula:. C2H4O2S.Na. Molecular weight ... InChI=1/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1. Structural formula:. Related substances. ...
3-Sulphanylpropanoyl)-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-D-arginylglycinamide cyclic (1→6 ... Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 25 Sep 2023), ASHP (updated 10 Sep ... 3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)metyl]-6,9,12,15,18-pentaoxo-13-(phenylmetyl)1,2-ditia-5,8,11,14,17- ...
Very high dose mercaptopropionic acid (MPA), 1-Ethyl-3-(3-dimethylaminopropyl) .... Exemestane for sale. I have searched know ...
... and oleic acid-capped CdSe quantum dots : interparticle distance, anchoring groups, and surface passivation  Santos, José ... 3-arylisoxazolyl-5-carboxylic acid and 5-(hydroxymethyl)-3-aryl-2-isoxazoline as molecular platforms for liquid-crystalline ... A síntese de uma plataforma molecular para materiais líquido-cristalinos derivados do ácido 3-arilisoxazolil-5-carboxílico (1) ... e do 5-(hidroximetil)-3-aril-2-isoxazolina (2) é descrita. Os intermediários 1 e 2 são obtidos ... ...
... and oleic acid-capped CdSe quantum dots : interparticle distance, anchoring groups, and surface passivation  Santos, José ... 3-arylisoxazolyl-5-carboxylic acid and 5-(hydroxymethyl)-3-aryl-2-isoxazoline as molecular platforms for liquid-crystalline ... A síntese de uma plataforma molecular para materiais líquido-cristalinos derivados do ácido 3-arilisoxazolil-5-carboxílico (1) ... e do 5-(hidroximetil)-3-aril-2-isoxazolina (2) é descrita. Os intermediários 1 e 2 são obtidos ... ...
Acid Value mg, KOH/g. 0.04 max. Purity Area, %. 99.5 min. Volatile content Weight, %. 0.1 max. ...
A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV ... 3,/tspan, ,tspan style=font-size: 12.50px; x=6.2515001 y=0,H,/tspan, ,/text, ,text transform=matrix(1,0,0,-1,-56.67, ... 3,/tspan, ,tspan style=font-size: 12.50px; x=6.2515001 y=0,H,/tspan, ,/text, ,text transform=matrix(1,0,0,-1,-56.67, ... 3,/tspan, ,tspan style=font-size: 12.50px; x=6.2515001 y=0,H,/tspan, ,/text, ,text transform=matrix(1,0,0,-1,-56.67, ...
Conveniently, all peptide X variants needed for our work share identical IntC-A (35 amino acids) and IntN-B (11 amino acids) ... Lynagh, T. et al. A selectivity filter at the intracellular end of the acid-sensing ion channel pore. eLife 6, doi:10.7554/ ... Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid ... Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. Proc Natl Acad Sci U S A 115, ...
... mercaptopropionic acid. In vitro cytotoxicity and imaging/internalization of the as-prepared MP A-InP/ZnSe and MP A-capped CdTe ... Water compatibility was achieved through ligand exchange with 3- ...
3-mercaptopropionic acid. 3-MPA is widely used in food and beverage industries as a flavoring agent. It is used in the ...
16.8 Msongamano Husika 1.13-1.30 Thamani ya Asidi 500-550 Madhara Wajibu wa mercapto propionic acid, utendaji wa juu wa asidi ... Uainisho wa Bidhaa: Jina la bidhaa Acrylic acid CAS No. 79-10-7 Formula Ch2chcooh Maelezo Kioevu safi chenye harufu inayowasha. ... 3-Mercaptopropionic Acid ,3MPA ,107-96-0. Uainisho wa Bidhaa: Uainisho wa Kipengee cha Jaribio Mwonekano wa chroma kioevu isiyo ... ya mercapto propionic kudhibiti uzito wa Masi ya superplasticizer ya asidi ya polycarboxylic, kuboresha kiwango cha upunguzaji ...
... formed by a molecular layer of phosphonic acids substituted by carbazole, which selectively extracts the positive charge ... Adding 3-MPA enhances the contact between the perovskite material and the solar cells textured substrate to improve ... To address this, the researchers introduced a special molecule called 3-mercaptopropionic acid (3-MPA) into the solar cells ...
cas 209995-38-0 2,4,5-trifluorophenylacetic acid. 209995-38-0. cas 25357-81-7 3-aminopropyltris(trimethylsiloxy)silane. 25357- ... cas 16004-75-4 1,3,5,7-tetraphenyladamantane. 16004-75-4. cas 2766-43-0 boc-l-serine methyl ester. 2766-43-0. cas 10298-80-3 4- ... 10298-80-3. cas 72287-26-4 [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(ii). 72287-26-4. cas 546-28-1 (+)-beta- ... cas 27144-18-9 s-trityl-3-mercaptopropionic acid. 27144-18-9. cas 156928-09-5 (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-ol. ...
Bongkrekik acid. *Bosy-Westphal 2009 Br J Nutr. *Bound energy. *Bovine serum albumin ...
author keywords: Mixed Valence States; X-ray Absorption Spectroscopy; Ti and Sc L-2,L-3 Transitions; In-Plane Hopping ... MeSH headings : 3-Mercaptopropionic Acid / chemistry; Cadmium Compounds / chemistry; Crystallization; Electrochemistry / ...
3-Mercaptopropionic acid. Price : 100 INR. Minimum Order Quantity : 1. Purity : 99%. Molecular Formula : C3H6O2S. Appearance : ...
mercaptopropionic acid; CYS; Thioserine Beilstein Registry No 1721408 EINECS Number 200-158-2 ... L-Cysteine is one of the sulfur containing proteinogenic amino acid incorporated into proteins as directed by the genetic code. ... Mammalian liver can synthesize L-cysteine and is a semi-essential amino acid. L-cysteine prevents oxidation of nerve cells, ... L-Cysteine is a proteinogenic amino acid incorporated into proteins as directed by the genetic code. The thiol-side chain ...
Merck 100631 Salicylic acid EMPROVE® ESSENTIAL Ph Eur,BP,USP. Synonyms: 2-Hydroxybenzoic acid ... Merck 808076 Thioacetic acid for synthesis. CAS 507-09-5, EC Number 208-063-8, chemical formula CH₃COSH.. ... Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).. ... 1310-58-3. 215-181-3. HKO. KOH. 56.11 g/mol. Ph Eur,BP,JP,NF,FCC,E 525. ...
You are viewing an interactive 3D depiction of the molecule l-carboxymethylcysteine (C5H9NO4S) from the PQR.
Citric acid monohydrate 1.7 mg. *Disodium phosphate dihydrate 3 mg. *Benzalkonium chloride solution (50%) 0.2 mg ... For children aged 3 months to 12 years, the usual dosage range is 0.05 mL (5 mcg) to 0.3 mL (30 mcg) daily, either as a single ... 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) trihydrate.. *Desmopressin Acetate Nasal Spray is ... About 1/4 to 1/3 of patients can be controlled by a single daily dose of Desmopressin Acetate administered intranasally. Fluid ...
Mercaptopropionic Acid, Dimethicone, Butylated Hydroxytoluene.. *Clear Builder Gel Ingredients: Acrylates Copolymer, ...
... and Ringers containing nipecotic acid ( violet trace ). The increase in peak area produced by nipecotic acid confirmed the ... and Ringers containing nipecotic acid ( violet trace ). The increase in peak area produced by nipecotic acid confirmed the ... gamma-aminobutyric acid, isoflurane, reticular formation of pons, wakefulness, microdialysis, inspiration, respiration, ... 1. γ-Aminobutyric acid (GABA) levels in cat pontine reticular formation are reliably quantified using in vivo microdialysis and ...
Global 3-in-1 Commodes Market Research Report 2019 (Includes Business Impact of COVID-19) Published : 03, May ... Global 3-Mercaptopropionic Acid Market Research Report 2019 (Includes Business Impact of COVID-19) Published : 03, May ... WorldWide 3-Hexenyl Salicylate Market, Industry / Sector Analysis Report, Regional Outlook & Competitive Market Share & ... 1.3.3 Consumer electronics 1.3.4 Automotive 1.3.5 Healthcare 1.3.6 Retail 1.4 Global 3D XPoint Technology Market by Region 1.4. ...
To assemble a label-free MMP-1 immunosensor layer-by-layer, 3-mercaptopropionic acid was utilized due to its strong sulfur-gold ... HSC-3 & C6) of oral and brain cancers showing results comparable to those of the credible ELISA method. This journal is ... 3-dimethylaminopropyl) and N′ ethylcarbodiimide hydrochloride method. Differential pulse voltammetry analysis showed a linear ...
A solution of acrylic acid with testosterone as the imprinted template was infiltrated in the colloidal crystal and polymerized ... 3. An in-depth analysis of nucleation and growth mechanism of CdS thin film synthesized by chemical bath deposition (CBD) ... via bulk polymerization; the particles were then removed by acid etching and the testosterone eluted by a suitable solvent. The ... In the one-step fabrication technique, 3-Mercaptopropionic Acid (MPA) was employed as a second source of sulphur ions and a ...
  • L-Cysteine is one of the sulfur containing proteinogenic amino acid incorporated into proteins as directed by the genetic code.The thiol-side chain participates in a variety of oxidation/reduction reactions within the cell. (beyotime.com)
  • Mammalian liver can synthesize L-cysteine and is a semi-essential amino acid. (beyotime.com)
  • L-Cysteine is a proteinogenic amino acid incorporated into proteins as directed by the genetic code. (beyotime.com)
  • In addition, L-cysteine can be converted into hydrogen sulfide and pyruvic acid through the action of the enzyme cystathionine gamma-lyase. (cannabisdatabase.ca)
  • Some examples of depilatory actives include: potassium or calcium thioglycolate, thioglycerol, 2-mercaptopropionic acid, monoethanolamine thioglycolic acid, homocysteine, cysteine and glutathione, etc. (see Depilatory Actives ). (cosmeticsandtoiletries.com)
  • It is a bifunctional molecule, containing both carboxylic acid and thiol groups. (wikipedia.org)
  • When trimellitic anhydride or maleic anhydride are used, carboxylic acid functional resins can be obtained. (pittureevernici.it)
  • Moreover, additional carboxylic acid functionality can be incorporated via radical polymerisation of a monomers mixture containing (meth)acrylic acid monomer (Figure 3). (pittureevernici.it)
  • Since Lescher and col. prepared the nalidixic acid in 1962 [ 1 ], the synthesis of new quinolones continues (Figure 1 ). (hindawi.com)
  • In the present work we reported the synthesis, characterization, and biological activity results of a copper mixed complex (see Figure 1 ), with hsm and nalidixic acid. (hindawi.com)
  • Each rat received microinjections of Ringer's (vehicle control), the GABA uptake inhibitor nipecotic acid, and the GABA synthesis inhibitor 3-mercaptopropionic acid. (silverchair.com)
  • In the one-step synthesis process, Salvia dye, Ag, and 3-Mercaptopropionic acid (MPA) were used. (bvsalud.org)
  • To address this, the researchers introduced a special molecule called 3-mercaptopropionic acid (3-MPA) into the solar cells' self-assembled monolayer (SAM) formed by a molecular layer of phosphonic acids substituted by carbazole, which selectively extracts the positive charge carriers ("holes") that are produced under illumination in the perovskite films. (myscience.ch)
  • In the one-step fabrication technique, 3-Mercaptopropionic Acid (MPA) was employed as a second source of sulphur ions and a linker molecule. (bvsalud.org)
  • Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as 'tags' coupled with Pd(0)-mediated Suzuki-Miyuara 'modification' has been enabled by discovery of an effective small molecule palladium scavenger. (ox.ac.uk)
  • Organic esters of thioglycolic acid (HS-CH2COOH). (rush.edu)
  • This depilatory action allows for the formation of new disulfide bonds (e.g., thioglycolic acid). (cosmeticsandtoiletries.com)
  • The most widely used category of alkaline bases are mercaptans, known as thioglycolic acid (and salts). (cosmeticsandtoiletries.com)
  • A key limitation of thioglycolic acid and its derivatives is susceptibility to oxidation by mechanisms such as air, high temperatures and trace metal-ions. (cosmeticsandtoiletries.com)
  • Semi-synthetic approaches offer an alternative means to manipulate proteins post-translationally, but these modifications have typically been performed in vitro 3 - 8 . (biorxiv.org)
  • Grisemycin, salinipeptin, and cypemycin belong to the linaridin class of ribosomally synthesized and posttranslationally modified peptides that contain multiple dehydrobutyrine and D-amino acid residues. (hokudai.ac.jp)
  • Furthermore, we demonstrated that GrmH/GrmL complex accepted salinipeptin and cypemycin precursor peptides, which possess three additional amino acids. (hokudai.ac.jp)
  • It is derived from the addition of hydrogen sulfide to acrylic acid. (wikipedia.org)
  • Of special interest is the esterification reaction with unsaturated fatty acids 4 . (pittureevernici.it)
  • For example, further reaction with an anhydride compound can give alkyd resins or polyol resins with carboxyl acid groups, depending on the type/amount of anhydride compound used and the reaction conditions. (pittureevernici.it)
  • Formulators creating a hair depilation product typically are cautioned not to use fatty acid esters due to their instability at high pH levels. (cosmeticsandtoiletries.com)
  • The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)
  • 3-Mercaptopropionic acid (3-MPA) is an organosulfur compound with the formula HSCH2CH2CO2H. (wikipedia.org)
  • This nanocomposite was prepared with slight modification of nanocrystalline cellulose (NCC) with cationic surfactant of cetyltriammonium bromide (CTAB) and further decorated with 3-mercaptopropionic acid (3-MPA) capped CdS QDs. (afpm.org.my)
  • Carbapenems resistant isolates were screened for MβL production by disk approximation test using 2 enzyme inhibitors (EDTA and 2-mercaptopropionic acid). (unifesp.br)
  • Here we present a new approach to incorporate single or multiple post-translational modifications or non-canonical amino acids into soluble and membrane proteins expressed in eukaryotic cells. (biorxiv.org)
  • The added value of using this polyol copolymer is that it can facilitate the preparation of high solids formulations with a faster cure for coating/paint, ink or adhesive applications 3 . (pittureevernici.it)
  • The major and most abundant compounds were rosmarinic acid (570 ± 14 μg/g extract in the methanolic extract), ferrulic acid (336 ± 6 μg/g extract in the methanolic extract), (+)-catechin (340 ± 4 μg/g extract in the water extract), apigenin (182 ± 4 μg/g extract in the methanolic extract), and epicatechin (188 ± 12 μg/g extract in the water extract). (afpm.org.my)
  • We investigated CO electro-oxidation features by scan-rate-dependent Tafel analysis and a model system experiment based on adsorption of 3-mercaptopropionic acid (3-MPA). (researcher-app.com)
  • However, despite recent technical achievements 1 , 2 , the type of chemical modification that can be accomplished by genetic means (e.g. amber codon suppression) is limited to incorporation of non-canonical amino acids (ncAAs) due to the tolerance of the cell's translational machinery. (biorxiv.org)
  • To illustrate this, a model similar to the human round window membrane has been developed and superparamagnetic iron oxide (Fe 3 O 4 ) nanoparticles were magnetically transported through three co-cultured layers of cells. (biomedcentral.com)
  • Mn-doped ZnS quantum dots (QDs) coated by 3-mercaptopropionic acid (MPA) and methylene blue (MB) formed nanobridges by electrostatic interaction, which were then used to detect trace DNA. (alfa-chemistry.com)
  • Approximately 3 decades ago, quantum dots (QDs) emerged as a notable class of nanomaterials because of their unique set of optical, electronic, magnetic, and chemical properties [ 1 - 3 ]. (springer.com)
  • The identification of 2,2'-diphenic acid in culture extracts indicates that phenanthrene was initially attacked through dioxigenation at C9 and C10 to give cis-9,10-dihydrodiol. (afpm.org.my)
  • The CdS + MPA films displayed the highest carrier concentration whereas the CdS + Ag + MPA films exhibited the lowest resistivity, with a jump of 3 orders of magnitude. (bvsalud.org)
  • Tiopronin undergoes slow absorption, reaching peak plasma concentration 3-6 hours after ingestion. (drugbank.com)
  • 3-Mercaptopropionic acid was tested for acute toxicity towards fish according to OECD-Test Guideline 203. (europa.eu)
  • A full set of short-term toxicity data is available for 3-MPA, but no long-term ecotoxicity data. (europa.eu)
  • 5%). This immunosensor was successfully applied for MMP-1 detection in urine, saliva, bovine serum, and cell culture media (HSC-3 & C6) of oral and brain cancers showing results comparable to those of the credible ELISA method. (edu.hk)
  • The test material has a corrected coefficient of 4.81×10-3, log10P'ow=-2.32 at pH=7. (europa.eu)
  • The study performed in experimental laboratory (Fox, 2009, Harlan), dedicated to estimate the partition coefficient of the test material 3-mercaptopropionic acid, has been chosen as a key study. (europa.eu)
  • Adding 3-MPA enhances the contact between the perovskite material and the solar cell's textured substrate to improve performance and stability, allowing it to disassemble molecular carbazole clusters, and ensuring a more even distribution of the molecules in the self-assembled monolayer. (myscience.ch)
  • examples of these drugs are Nalidixic acid, Oxolinic acid and Cinoxacin. (hindawi.com)
  • However, before proposing testing in vertebrate animals as a last resort, a Daphnia reproduction study with 3-MPA is proposed to be conducted first. (europa.eu)
  • Modifying the Pt surface with 3-MPA can reduce the OH coverage, which in turn reduces the width of the first peak. (researcher-app.com)
  • Water compatibility was achieved through ligand exchange with 3- mercaptopropionic acid. (uwc.ac.za)
  • 3 Synaptic terminals from local and distant γ-aminobutyric acid (GABA)-containing neurons 4,5 as well as GABA type A (GABA A ) receptors 6-8 are present in the pontine reticular formation and modulate behavioral arousal. (silverchair.com)
  • It is based on limited therapeutic outcome data ( 3 , 31 ), pharmacokinetic/pharmacodynamic data ( 3 ), and the concept that the lower the cephalosporin MIC the greater the likelihood of successful therapy ( 3 , 19 , 31 ). (asm.org)