3-Mercaptopropionic Acid: An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.Myoclonus: Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).Alcaligenaceae: A family of gram-negative, aerobic, non-spore forming rods or cocci. Well known genera include ACHROMOBACTER; ALCALIGENES; and BORDETELLA.Propionates: Derivatives of propionic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxyethane structure.Carnitine O-Acetyltransferase: An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1.7.Sulfhydryl Compounds: Compounds containing the -SH radical.Palmitoylcarnitine: A long-chain fatty acid ester of carnitine which facilitates the transfer of long-chain fatty acids from cytoplasm into mitochondria during the oxidation of fatty acids.Acetyl-CoA C-Acyltransferase: Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is formed.Allyl CompoundsAcyl-CoA Dehydrogenases: Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS.Pyridoxine: The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."Papio: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.Formularies as Topic: Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.Economics, Pharmaceutical: Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Glutamate Decarboxylase: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)tau Proteins: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Protein Kinase C: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Acrylonitrile: A highly poisonous compound used widely in the manufacture of plastics, adhesives and synthetic rubber.AcrylatesRubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Cell Membrane Permeability: A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Deamino Arginine Vasopressin: A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Antidiuretic Agents: Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS.Administration, Intranasal: Delivery of medications through the nasal mucosa.Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Renal Agents: Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Quantum Dots: Nanometer sized fragments of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY TECHNIQUES.Nanomedicine: The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).Cadmium Compounds: Inorganic compounds that contain cadmium as an integral part of the molecule.Superoxides: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Nanoconjugates: Tailored macromolecules harboring covalently-bound biologically active modules that target specific tissues and cells. The active modules or functional groups can include drugs, prodrugs, antibodies, and oligonucleotides, which can act synergistically and be multitargeting.NADPH Oxidase: A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.Coated Materials, Biocompatible: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.Biomimetic Materials: Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Surface-Active Agents: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.

Specific adhesion of vesicles monitored by scanning force microscopy and quartz crystal microbalance. (1/62)

The specific adhesion of unilamellar vesicles with an average diameter of 100 nm on functionalized surfaces mediated by molecular recognition was investigated in detail. Two complementary techniques, scanning force microscopy (SFM) and quartz crystal microbalance (QCM) were used to study adhesion of liposomes consisting of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine and varying concentrations of N-((6-biotinoyl)amino)hexanoyl)-1, 2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (biotin-X-DHPE). Monitoring the adhesion of the receptor-doped vesicles to avidin-coated gold surfaces by QCM (f(0) = 5 MHz) revealed an increased shift in resonance frequency with increasing biotin concentration up to 10 mol% biotin-X-DHPE. To address the question of how the morphology of the liposomes changes upon adhesion and how that contributes to the resonator's frequency response, we performed a detailed analysis of the liposome morphology by SFM. We found that, with increasing biotin-concentration, the height of the liposomes decreases considerably up to the point where vesicle rupture occurs. Thus, we conclude that the unexpected high frequency shifts of the quartz crystal (>500 Hz) can be attributed to a firm attachment of the spread bilayers, in which the number of contacts is responsible for the signal. These findings are compared with one of our recent studies on cell adhesion monitored by QCM.  (+info)

Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma. (2/62)

Because bradykinin (BK) appears to have cardioprotective effects ranging from improved hemodynamics to antiproliferative effects, inhibition of BK-degrading enzymes should potentiate such actions. The purpose of this study was to find out which enzymes are responsible for the degradation of BK in human plasma. Human plasma from healthy donors (n = 10) was incubated with BK in the presence or absence of specific enzyme inhibitors. At high (micromolar) concentrations, BK was mostly (>90%) degraded by carboxypeptidase N (CPN)-like activity. In contrast, at low (nanomolar) substrate concentrations, at which the velocity of the catalytic reaction is equivalent to that under physiological conditions, BK was mostly (>90%) converted into an inactive metabolite, BK-(1-7), by angiotensin-converting enzyme (ACE). BK-(1-7) was further converted by ACE into BK-(1-5), with accumulation of this active peptide. A minor fraction (<10%) of the BK was converted into another active metabolite, BK-(1-8), by CPN-like activity. The present study shows that the most critical step in plasma kinin metabolism, i.e., inactivation of BK, is mediated by ACE. Thus inhibition of plasma ACE activity would be cardioprotective by elevating the concentration of BK in the circulation.  (+info)

Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic rats. (3/62)

1. The successive effects of the angiotensin-converting enzyme inhibitor captopril (CAP, 2 mg kg(-1)+1 mg kg(-1) 30 min(-1) infusion) and the neutral endopeptidase 24-11 inhibitor retrothiorphan (RT, 25 mg kg(-1)+12.5 mg kg(-1) 30 min(-1) infusion) were studied on femoral vascular conductance (FVC) in streptozotocin-induced diabetic (STZ-SD) and control Sprague-Dawley (C-SD) rats. The role of the kinin-nitric oxide (NO) pathway was assessed by (1) using pre-treatments: a bradykinin (BK) B2 receptor antagonist (Hoe-140, 300 microg kg(-1)), a NO-synthase inhibitor (N(omega)-nitro-L-arginine methyl ester, L-NAME, 10 mg kg(-1)), a kininase I inhibitor (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, MGTA, 10 mg kg(-1)+20 mg kg(-1) 20 min(-1) infusion) and (2) comparing the effects in STZ-induced diabetic (STZ-BN) and control Brown-Norway kininogen-deficient (C-BN) rats. 2. In C-SDs, CAP and CAP+RT increased FVC similarly. In STZ-SDs, FVC and FBF were decreased compared to C-SDs. CAP+RT increased them more effectively than CAP alone. 3. In both C-SDs and STZ-SDs, the femoral bed vasodilatation elicited by CAP was inhibited by Hoe-140 and L-NAME. The FVC increase elicited by CAP+RT was not significantly reduced by Hoe-140 but was inhibited by L-NAME and Hoe-140+MGTA. 4. In C-BNs, the vasodilatator responses to CAP and CAP+RT were abolished and highly reduced, respectively. In STZ-BNs, these responses were abolished. 5. These results show that in STZ-SDs, CAP+RT improve FBF and FVC more effectively than CAP alone. These effects are linked to an increased activation of the kinin-NO pathway. BK could lead to NO production by BK B2 receptor activation and another pathway in which kininase I may be involved.  (+info)

Persistent activation of GABA(A) receptor/Cl(-) channels by astrocyte-derived GABA in cultured embryonic rat hippocampal neurons. (4/62)

Whole cell patch-clamp recordings using Cl(-)-filled pipettes revealed more negative levels of baseline current and associated current variance in embryonic rat hippocampal neurons co-cultured on a monolayer of astrocytes than those cultured on poly-D-lysine. These effects were mimicked by culturing neurons on poly-D-lysine in astrocyte-conditioned medium (ACM). The baseline current and variance decreased immediately in all cells after either local perfusion with saline or exposure to bicuculline, an antagonist of GABA at GABA(A) receptor/Cl(-) channels. Baseline current and variance in all cells reached a nadir at approximately 0 mV, the calculated equilibrium potential for Cl(-). Perfusion of ACM rapidly induced a sustained current in neurons, which also reversed polarity at approximately 0 mV. Bicuculline attenuated or eliminated the ACM-induced current at a concentration that completely blocked micromolar GABA-induced current. Quantitative analyses of spontaneously occurring fluctuations superimposed on the ACM-induced current revealed estimated unitary properties of the underlying channel activity similar to those calculated for GABA's activation of GABA(A) receptor/Cl(-) channels. Bicuculline-sensitive synaptic-like transients, which reversed at approximately 0 mV, were also detected in neurons cultured in ACM, and these were immediately eliminated along with the negative baseline current and superimposed current fluctuations by perfusion. Furthermore bicuculline-sensitive synaptic-like transients were rapidly and reversibly triggered when ACM was acutely applied. ACM induced an increase in cytoplasmic Ca(2+) in cultured embryonic hippocampal neurons that was completely blocked by bicuculline and strychnine. We conclude that astrocytes release diffusible substances, most likely GABA, that persistently activate GABA(A) receptor/Cl(-) channels in co-cultured neurons.  (+info)

Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages. (5/62)

This is the first report on the biosynthesis of a hitherto unknown, sulfur-containing polyester and also the first report on a bacterial polymer containing sulfur in the backbone. The Gram-negative polyhydroxyalkanoate (PHA)-accumulating bacterium Ralstonia eutropha synthesized a copolymer of 3-hydroxybutyrate and 3-mercaptopropionate, poly(3HB-co-3MP), when 3-mercaptopropionic acid or 3,3'-thiodipropionic acid was provided as carbon source in addition to fructose or gluconic acid under nitrogen-limited growth conditions. The peculiarity of this polymer was the occurrence of thioester linkages derived from the thiol groups of 3MP and the carboxyl groups of 3MP or 3HB, respectively, which occurred in addition to the common oxoester bonds of PHAs. Depending on the cultivation conditions and the feeding regime, poly(3HB-co-3MP) contributed up to 19% of the cellular dry weight, with a molar fraction of 3MP of up to 43%. The chemical structure of poly(3HB-co-3MP) was confirmed by GC/MS, IR spectroscopy, (1)H- and (13)C-NMR spectroscopy, and elemental sulfur analysis. The identification of this novel biopolymer reveals a new quality regarding the substrate range of PHA synthases and their capability for the synthesis of technically interesting polymers.  (+info)

Plasticity of rat central inhibitory synapses through GABA metabolism. (6/62)

1. The production of the central inhibitory transmitter GABA (gamma-aminobutyric acid) varies in response to different patterns of activity. It therefore seems possible that GABA metabolism can determine inhibitory synaptic strength and that presynaptic GABA content is a regulated parameter for synaptic plasticity. 2. We altered presynaptic GABA metabolism in cultured rat hippocampal slices using pharmacological tools. Degradation of GABA by GABA-transaminase (GABA-T) was blocked by gamma-vinyl-GABA (GVG) and synthesis of GABA through glutamate decarboxylase (GAD) was suppressed with 3-mercaptopropionic acid (MPA). We measured miniature GABAergic postsynaptic currents (mIPSCs) in CA3 pyramidal cells using the whole-cell patch clamp technique. 3. Elevated intra-synaptic GABA levels after block of GABA-T resulted in increased mIPSC amplitude and frequency. In addition, tonic GABAergic background noise was enhanced by GVG. Electron micrographs from inhibitory synapses identified by immunogold staining for GABA confirmed the enhanced GABA content but revealed no further morphological alterations. 4. The suppression of GABA synthesis by MPA had opposite functional consequences: mIPSC amplitude and frequency decreased and current noise was reduced compared with control. However, we were unable to demonstrate the decreased GABA content in biochemical analyses of whole slices or in electron micrographs. 5. We conclude that the transmitter content of GABAergic vesicles is variable and that postsynaptic receptors are usually not saturated, leaving room for up-regulation of inhibitory synaptic strength. Our data reveal a new mechanism of plasticity at central inhibitory synapses and provide a rationale for the activity-dependent regulation of GABA synthesis in mammals.  (+info)

Chiral separation by electrokinetic capillary chromatography using newly synthesized linear polymers containing L-amino acid moieties. (7/62)

Chiral linear polymers were prepared by the thermal polymerization of N-acryloyl-L-valine and N-acryloyl-L-alanine derivatives using 3-mercaptopropionic acid (3-MPA) as a radical transfer agent. C-Terminal groups of the derivatives were methyl and tert-butyl esters later removed, and N-methylamide moieties. The N'-methylamide derivative of N-acryloyl-L-valine was copolymerized with methyl ester at a molar mixing ratio of 1:1. The ester groups were removed to provide anionic linear polymers terminated with carboxylic acid of the amino acid residue. The polymers are thus shown to function as pesudostationary phases that separate enantiomeric solutes in electrokinetic capillary chromatography (EKC). Racemic 3,5-dinitrobenzoylamino isopropyl esters were separated with the polymer derived from N-acryloyl-L-valine esters and with the copolymer from N-acryloyl-L-valine methyl ester and N-acryloyl-L-valine N'-methylamide at pH 7.0. These separations could not be observed at pH 9.0 in migrating solutions containing anionic linear polymers. This pH dependence can be discussed from the standpoint of the microscopic hydrophobicity of the polymers, as assessed from the fluorescence of pyrene adsorbed onto the polymers in water.  (+info)

Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis. (8/62)

Arginine carboxypeptidase was isolated from the cytoplasm of Porphyromonas gingivalis 381 and purified by DEAE-Sephacel column chromatography, followed by high-performance liquid chromatography on DEAE-5PW and TSK G2000SW(XL). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified enzyme revealed the presence of three major bands at 42, 33, and 32 kDa with identical N-terminal sequences. By Western blotting analysis and immunoelectron microscopy, the arginine carboxypeptidase was found to be widely distributed in the cytoplasm and on the surface of the outer membrane. The open reading frame corresponding to the N-terminal amino acids of the arginine carboxypeptidase was detected by a search of the sequence of the P. gingivalis W83 genome. This sequence showed homology with mammalian carboxypeptidases (M, N, and E/H) and included a zinc-binding region signature, suggesting that the enzyme is a member of the zinc carboxypeptidase family. The purified enzyme was inhibited by EGTA, o-phenanthroline, DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, and some metal ions, such as Cu(2+), Zn(2+), and Cd(2+). On the other hand, Co(2+) activated the enzyme. The enzyme released arginine and/or lysine from biologically active peptides containing these amino acids at the C terminus but did not cleave substrates when proline was present at the penultimate position. These results indicate that the arginine carboxypeptidase produced by P. gingivalis is an exo type of metallocarboxypeptidase. This enzyme may function to release arginine in collaboration with an arginine aminopeptidase, e.g., Arg-gingipain, to obtain specific amino acids from host tissues during the growth of P. gingivalis.  (+info)

Study 1: A study was conducted to determine the potential skin sensitising properties of the test substance (Ammonium 2-mercaptopropionate) in a solution at 58.23% (a.i.) and at 20.38% (a.i.) in the guinea pig sensitisation test (Buehler) according to OECD Guideline 406, in compliance with GLP. Twenty test and ten control animals were used. Initially a 6 h induction exposure to the test substance was performed in the test group once weekly for three weeks. Two weeks later both test and control groups were subjected to a single 6 h challenge exposure with the test substance. Allergic responses to the challenge procedure were evaluated 24 and 48 h after the challenge. Under the study conditions, test substance at 58.23% gave a positive response in 5% of the animals. There was no positive sensitisation response at treatment with the test substance at 20.38% (Kaufmann, 1999). Study 2: A study was conducted to determine the sensitisation potential of the test substance (Ammonium 2-mercaptopropionate) ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Shijiazhuang Dowell Chemical Co.,Ltd.Supplies the best productions by high-tech,cherishes the beautiful nature by green technics...
NOKWEQU, Mbulelo G.; NKAMBULE, Comfort M. e GAMMON, David W.. A Serendipitous Formation of a Cysteine-bridged Disaccharide. S.Afr.j.chem. (Online) [online]. 2014, vol.67. ISSN 1996-840X.. N-acetyl-L-cysteine bearing free carboxylic acid and sulfhydryl groups was glycosylated with 1,2,3,4,6-Penta-O-acetyl-ß-D-glucopyranoside in the presence of SnCl4 as a promoter to give the S-glycosylated cysteine in 64 % yield. However, when excess donor was used, a previously unreported cysteine-bridged disaccharide was isolated in 54 % yield. The acetamido group on cysteine, which lowers the pKa of the carboxylic acid group of the amino acid, plays no role in the formation of the bridged disaccharide since 3-mercaptopropionic acid reacts in a similar manner to give the 3-mercaptopropionic acid-bridged disaccharide in 52 % yield.. Palavras-chave : Glycopeptides; glycosylation; bridged-disaccharides. ...
Intelligent" crosslinked nanoparticles (NPs) provide great advantages in enhancing drug bioavailability and reducing side effects in anticancer therapeutics. In this study, a novel biodegradable polyphosphoester-based functional copolymer prodrug PTX-(PBYP-g-MPA)-b-PEEP was prepared to construct pH/redox dual-responsive core-crosslinked nanoparticles (DOX/CCL NPs), in which paclitaxel (PTX) was conjugated to the polyphosphoester to form an amphiphilic prodrug and doxorubicin (DOX) was encapsulated inside the prodrug NPs. At first, PTX was used as an initiator to polymerize 2-(but-3-yn-1-yloxy)-2-oxo-1,3,2-dioxaphospholane (BYP) and 2-ethoxy-2-oxo-1,3,2-dioxaphospholane (EOP) by one-pot sequential ring-opening polymerization, yielding a biodegradable polymeric prodrug PTX-PBYP-b-PEEP. Subsequently, a radical-mediated thiol-yne "click" reaction was performed between the alkynyl groups on the PBYP segment and the thiol group of 3-mercaptopropionic acid (MPA) to form a functional carboxyl group at ...
The design of a catalyst for one of the most important electrocatalytic reactions, the oxygen reduction reaction (ORR), was done following the most recent guidelines of theoretical studies on this topic. Aim of this work was to achieve a synergic effect of two different metals acting on different steps of the ORR. The catalytic activity of Ag, already known and characterized, was enhanced by the presence of a monolayer of cobalt subdivided into nanosized islands. To obtain such a controlled nanostructure, a novel method utilizing self-assembled monolayers (SAMs) as templates was employed. In a recent study, we were able to perform a confined electrodeposition of cobalt onto Ag(111) in a template formed by selectively desorbing a short-chain thiol (3-mercaptopropionic acid, MPA) from binary SAMs using 1-dodecanthiols (DDT). [32] This method allows for an excellent control of the morphology of the deposit by varying the molar ratio of the two thiols. Because cobalt does not deposit on silver at an ...
A lube oil composition that inhibits lubricant viscosity increase and dispersency decrease is described. The composition includes an oil of lubricating viscosity and a mixture of specified functionalized derivatives of pentaerythritol tetrakis 3-mercaptopropionate and amine antioxidants.
An extended model is developed to predict the free-radical thiol-ene reaction dynamics between D-limonene, as a renewable diolefin, and a monothiol compound (iso-tridecyl 3-mercaptopropionate) in bulk liquid conditions. Thermally and photo-initiated reactions of the two monomers showed favored thiol-ene coupling at the exo-isopropenyl alkene structure when reacted at 1 : 1 and 1 : 0.5 mole ratios. Experimental kinetic data obtained from the two stoichiometries were well reproduced numerically via the simulation software COPASI by introducing a multi-route mechanistic scheme with propagation-chain-transfer steps accounting for primary (mono-additions) and secondary (di-addition) modes of coupling. The differences in intrinsic double-bond reactivity enable synthesis of limonene-terminated resins (mono-versus poly-disperse) as multifunctional network precursors. Off-stoichiometry manipulations in the initial mole ratio, assisted by numerical simulations, offer a convenient approach to visualize the ...
3-hydroxy-2,4,5-trihydroxymethylpyridine: precursor substrate for pyridoxine synthesis by Kloeckera apiculate (yeast); RN given refers to parent cpd; structure
pure IgG SA-20001-1 pure IgG SA-20001-2-1 pure IgG SA-20003-1 SA-20003-1-B SA-20003-1-Cy5 SA-20003-1-F SA-20003-1-HP SA-20003-1-PC5 SA-20003-1-PE pure IgG SA-20003-1AH pure IgG SA-20003-2-1 pure IgG SA-20004-1 pure IgG SA-20004-2-1 pure IgG SA-20005-1 SA-20005-1-200 pure IgG SA-20005-1-FAB pure IgG SA-20005-1-FAB2 pure IgG SA-20005-1-FC pure IgG SA-20005-10 SA-20005-11 SA-20005-11-B SA-20005-11-F SA-20005-11-HP SA-20005-11-PC5 SA-20005-11-PE SA-20005-12 SA-20005-12-APC SA-20005-12-B SA-20005-12-F SA-20005-12-HP SA-20005-12-PC5 SA-20005-12-PE SA-20005-13 SA-20005-13-B SA-20005-13-F SA-20005-13-HP SA-20005-13-PC5 SA-20005-13-PE SA-20005-21-B SA-20005-21-F SA-20005-21-HP SA-20005-21-PE Aff support SA-20005-AS-1 pure IgG SA-20006-1 pure IgG SA-20006-2 pure IgG SA-20006-3 pure IgG SA-20007-1-25 pure IgG SA-20007-1-5 pure IgG SA-20007-1-FAB pure IgG SA-20007-1-FAB2 pure IgG SA-20007-1-FC SA-20007-1-HP pure IgG SA-20007-2 pure IgG SA-20007-2-10 pure IgG SA-20007-2-5 pure IgG SA
The preparation, characterization and biocompatibility of soluble eggshell membrane (SEP) are reported. The dissolution process, which is the key step of the preparation of SEP, has been followed by scanning electron microscopy (SEM) to observe the changes of the surfaces and thickness of the eggshell membrane (ESM). The composition of SEP has been investigated by amino acid analysis and elemental analysis. Based on the fact that SEP losses significantly cystine, and that SEP has a higher content of sulfur, an assumption involving combination with 3-mercaptopropionic acid (the reagent used for reductive cleavage of disulfide bonds) following the cleavage of the original disulfide bonds has been proposed, which explains the solubility of SEP. The thermal and surface properties have been studied by thermogravimetric analysis (TGA) and contact angle measurement. The biocompatibility of SEP, as demonstrated by cell culture of NIH3T3, is comparable to collagen type I and superior to raw ESM either ...
Following a successful Legionella update held at BPEC offices, BPEC have now launched a new updated Legionella Risk Assessment and Water Disinfection for Mechanical Services training course, this new course will replace the Risk Assessment and Disinfection course which BPEC currently offer.. The new updated course does have a defined scope for those candidates wanting to only undertake the risk assessment element.. BPEC will cease to offer their separate Risk Assessment and Disinfection course from 1st April 2015, centres who attended the update will be given access to the new material, centres wanting to offer the new course will need to be approved or re-approved by contacting BPEC.. The Risk Assessment and Disinfection manuals have now been combined into one reducing the cost to centres; the new manual cost is £65 and again includes a validation sticker.. The new course material is now available to download from the BPEC website to all approved centres.. Please contact our Services team for ...
The development of biocompatible polymers using thiol-acrylate Michael addition reactions between not only acrylates and thiols but also between amines and acrylates were demonstrated. The synthesis of an in situ tertiary amine catalyst initiates the propagation steps of the polymerization process by subsequently reacting with trimethylolpropane tris (3-mercaptopropionate) (TMPTMP). A few notable characteristics of this reaction are tunable gel times, the capability of reaching high polymer conversion and suitable mechanical strength. With addition of hydroxyapatite to the polymeric phase and foaming, a porous bone composite was produced. Further osteogenisis and in vivo work using the PETA-co-TMPTMP (HA) composite material was analyzed. The PETA-co-TMPTMP-co-TMTMP with 20%HA showed an increase in osteogenic potential higher than the FDA approved PCL over the 21-day study. The rats did not exhibit any severe systemic responses from the polymer implant, and an increase in bone growth was observed for the
The WikiPremed MCAT Course is an open access, comprehensive learning program for college physics, chemistry, biology, and organic chemistry within a unified, spiraling curriculum.
Alright. So Tyrosine is a precursor substrate for adrenaline, noradrenaline, and dopamine in the brain (catecholamines). This study helped us understand it better (click here). As far as we could tell, Tyrosine by itself does not appear to have any major impact on sports performance.. Human studies examining its effect with caffeine vs. caffeine vs. placebo are nil from what we could find. The reason it is in the mix is because empirical evidence suggests that it works synergistically with caffeine. Simply put - it has an impact as a pre-workout stimulant when combined with caffeine. We have found this to be the case as well. Since tyrosine can increase catecholamine production and caffeine can increase catecholamine release - these two compounds should work together to increase the energy effect.. Although there are not numerous studies examining its effect when paired just with caffeine - from an expert review and empirical evidence standpoint its use when paired with caffeine is well ...
Biologically active sulfur is one of the most critical nutrients for our bodies to remain youthful and energetic. As we age, along with a diet deficient in essential nutrients, our bodies become stiff, our cells become rigid, and our overall energy begins to rapidly decelerate. MSM (methylsulfonylmethane) is an organic sulfur compound thats naturally derived during the ... Continue Reading ...
Page contains details about 4DT-coated PbSe quantum dots . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Aminoguanidine lanthanide thiodipropionate hydrates of composition [Ln(Agun)<sub>2</sub>(tdp)<sub>3</sub>&#183nH<sub>2</sub>O], Agun = Aminoguanidine, tdp = thiodipropionic acid, where Ln = La, Pr, Nd and Sm if n = 2, have been prepared and characterized by physic-chemical techniques.
This plant is well deserving of cultivation on light dry and high elevated inferior soils, and on such will yield a greater bulk of herbage than any of the cultivated clovers. It is highly nutritious, and eaten with avidity by cattle. From the great depth to which its roots penetrate, it is not liable to be injured by drought, and is thereby enabled to retain its verdure after the grasses and other plants are burnt up ...
On Thu, 2011-10-06 at 19:22 -0400, PIRA (Preethi Ramaiya) wrote: , Is there a way to convert multiple GFF3 files into EMBL format with , the correct "join" for euk. CDSes? Artemis is able to correctly read , and write the GFF3 /EMBL file I have but how do I do this for multiple , contig files. Bioperlish options seem straightforward for a one exon , -,one CDS mode. I have Parent and ID tags in gene/transcript/CDS , structure ...
Anoxia-tolerant vertebrates decrease their metabolic rate by 70% or more during anoxia, while the major inhibitory neurotransmitter in the vertebrate brain, GABA, increases in concentration. To test the possibility that GABA could be a mediator of anoxic metabolic depression, crucian carp (Carassius carassius L.) were given an inhibitor of GABA synthesis, isoniazid, and the rate of anoxic ethanol production (ethanol being the main end product of energy metabolism in anoxic crucian carp) as well as the rates of normoxic and hypoxic oxygen consumption were measured. Isoniazid (500mgkg−1), which significantly inhibited the anoxia-induced rise in brain GABA concentration, caused a nearly threefold increase in anaerobic ethanol production without affecting normoxic oxygen consumption. The GABA synthesis inhibitor 3-mercaptopropionic acid (3-MP, 200mgkg−1) and the GABA receptor antagonist securinine (20mgkg−1) caused similar rises in anoxic ethanol production. Nevertheless, crucian carp given ...
If you havent heard about what organic sulfur can do for your busy life yet, then youre missing out on all the fun. Im a married work at home managing 4 kids and 2 dogs. Im busy. Who isnt? Youre busy too. Every month I keep taking my organic sulfur, I find myself with more kick in my step. Organic sulfur is
Sulfur is an essential element for growth and physiological functioning of plants. However, its content strongly varies between plant species and it ranges from 0.1 to 6% of the plants dry weight. Sulfates taken up by the roots are the major sulfur source for growth, though it has to be reduced to sulfide before it is further metabolized. Root plastids contain all sulfate reduction enzymes, but the reduction of sulfate to sulfide and its subsequent incorporation into cysteine predominantly takes place in the shoot, in the chloroplasts. Cysteine is the precursor or reduced sulfur donor of most other organic sulfur compounds in plants. The predominant proportion of the organic sulfur is present in the protein fraction (up to 70% of total sulfur), as cysteine and methionine (two amino acids) residues. Cysteine and methionine are highly significant in the structure, conformation and function of proteins. Plants contain a large variety of other organic sulfur compounds, as thiols (glutathione), ...
Have you ever wondered whats the difference between MSM and Organic Sulfur? Maybe not. But thats okay, because I think youll actually find it quite fascinating.
Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing amino acids and does not lead to direct excretion of sulfide. In the dissimilatory pathway, which is restricted to obligatory anaerobic bacterial and archaeal lineages, sulfate (or sulfur) is the terminal electron acceptor of the respiratory chain producing large quantities of inorganic sulfide. Both pathways start from the activation of sulfate by reaction with ATP to form adenylyl sulfate (APS). In the assimilatory pathway [MD:M00176] APS is converted to 3-phosphoadenylyl sulfate (PAPS) and then reduced ...
Sulfur is an essential element for life and the metabolism of organic sulfur compounds plays an important role in the global sulfur cycle. Sulfur occurs in various oxidation states ranging from +6 in sulfate to -2 in sulfide (H2S). Sulfate reduction can occur in both an energy consuming assimilatory pathway and an energy producing dissimilatory pathway. The assimilatory pathway, which is found in a wide range of organisms, produces reduced sulfur compounds for the biosynthesis of S-containing amino acids and does not lead to direct excretion of sulfide. In the dissimilatory pathway, which is restricted to obligatory anaerobic bacterial and archaeal lineages, sulfate (or sulfur) is the terminal electron acceptor of the respiratory chain producing large quantities of inorganic sulfide. Both pathways start from the activation of sulfate by reaction with ATP to form adenylyl sulfate (APS). In the assimilatory pathway [MD:M00176] APS is converted to 3-phosphoadenylyl sulfate (PAPS) and then reduced ...
As outlined by our hosts, if society would take responsibility and add sulfur to their diet, theyd be no need for a broken health care system like Medicare ...
Anglick slovn k - p eklad anglick ch slov sulphur, organic sulphur, precipitated sulphur, pyritic sulphur, refined sulphur do e tiny
|h3|Ingredients:|/h3| |p class=quicklist||span onclick=scrollslide(ing1)|Aqua (H2Os Fancy Name)|/span|, |span onclick=scrollslide(ing2)|Dimethyl Sulfone (MSM Organic Sulphur)|/span|, |span onclick=scrollslide(ing3)|Cetearyl Alcohol (Plant
|h3|Ingredients:|/h3| |p class=quicklist||span onclick=scrollslide(ing1)|Aqua (H2Os Fancy Name)|/span|, |span onclick=scrollslide(ing2)|Dimethyl Sulfone (MSM Organic Sulphur)|/span|, |span onclick=scrollslide(ing3)|Cetearyl Alcohol (Plant
Lead Selenide Quantum Dots PbSe bulk & research qty manufacturer. Properties, SDS, Applications, Price. Free samples program. Term contracts & credit cards/PayPal accepted.
This volume focuses on biosynthesis, metabolism, biodegradation, functions, properties and applications of miscellaneous polymers, such as hemozoin, thymine-containing styrene polymers, polythioesters, polyphosphate, polyhydroxymethionine, polyketides, natural polyacetals, biodegradation of a wide range of synthetic polymers.
This volume focuses on biosynthesis, metabolism, biodegradation, functions, properties and applications of miscellaneous polymers, such as hemozoin, thymine-containing styrene polymers, polythioesters, polyphosphate, polyhydroxymethionine, polyketides, natural polyacetals, biodegradation of a wide range of synthetic polymers.
In this thesis, the development of a newbiotechnological process for the treatment of undiluted sulfidic spent caustics (SSCs) using soda lake bacteria is described. SSCs are waste solutions that are formed in the oil and gas industry due to the caustic (NaOH) scrubbing of hydrocarbon streams for the removal of sulfur compounds.Without treatment, SSCs may impose serious environmental problems because of their alkalinity (pH>12), salinity (Na+ 5-12 wt%) and high sulfide (HS- and S2-) levels. Depending on the hydrocarbon stream that is treated, SSCs may also contain organic sulfur compounds and monoaromatic hydrocarbons. Biological treatment of undiluted SSCs would be a cheaper and safer alternative to the currently applied physico-chemical treatment methods (e.g., wet air oxidation or deep well disposal) since no additional chemicals are needed and the process works at ambient pressure and temperature conditions.. In chapter 2 the biological treatment of refinery SSCs is described in ...
Helps hair and nail growth, great for glowing skin! A must for active people, MSM helps relieve sore muscles by removing lactic acid build-up in muscle tissue. Helps our bodies use vitamins, magnifying their effect. The bond that secures the building blocks for cellular integrity. Kate says Dont even get me started! I am a total MSM fan! This amazing sulfur compound works for everything- and I mean everything, from hair, acne, muscle recovery, arthritis, carpel tunnel. I read the book The Miracle of MSM because I was amazed with the results I was experiencing. This is one of the products I take consistently everyday. I mix a little bit in a smoothie or water 2 times a day for all the benefits. You can also sprinkle a little on toothpaste for a whitening effect or make a paste for those stubborn acne spots.. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. ...
The research into sulfur revealed a relationship between oxygen and cancer, aerobic verses anaerobic cellular metabolism as described by Otto Warburg. He received a Noble Prize for proving that cancer was anaerobic in 1930. One on line Study from Great Britain described 28,000 women who chose not to repeat surgery, chemotherapy or radiation therapy for their breast cancer but opted to take a pure form of MSM and had no reoccurrence of their cancer from 1975 to 2000. That article made me encourage my son to take sulfur. He is alive and cancer free 8 years later. Our Study was begun in an effort to explain not only that we are sulfur deficient but that most of the MSM methylsulfonylmethane which we tested was not as effective as demonstrated by the early researcher such as Dr. Stanley Jacob. The examples of cellular regeneration did not begin to be reported until we found a pure crystal precipitate which was not processed past precipitation. When this same crystal was pulverized our Study ...
Feed your body with Magos Minerals - Topically nourish your body with MSM (Organic Sulphur) and Magnesium. Keep it next to your gym bag!
Our daily hair conditioner promotes silkiness and fullness, and is a mild hair detangler. It contains Dimethyl Sulfone (MSM), a natural source of organic sulfur. It is enriched with wheat and soy proteins, antioxidants, vitamins, herbs, minerals, meadowfoam seed oil (a mild detangler) and essential
MSM Tablets containing on average 1000mg of MSM. MSM (Methylsulphonylmethane) is a naturally occurring organic sulphur… by Power Health from the Health Shop at WWSM
organic sulphur - Middle Easts Largest Energy Portal, which delivers latest news, data, analysis and opinion for the regions Energy Professionals. It is designed to give readers an informative overview of the months major industry news while focusing on market reviews, product and technical information, directories, events and objective profiles.
Cation exchange occurs via defect initiated solid-state diffusion, a process that can lead to defect formations. The effect of such inherent defect formation on carrier dynamics of cation-exchanged heterostructures remains poorly understood. Herein, we report exciton dynamics in type II CdSe/PbSe heterostructure nanorods formed via cation exchange. The majority of electrons in CdSe domains decays in 5 ps due to ultrafast carrier trapping. The defect generated by cation exchange can be healed by annealing the as-synthesized CdSe/PbSe heterostructure nanorods. This study suggests a strategy for improving properties of heteronanostructures prepared by cation exchange for applications in photovoltaics and photocatalysis ...
Sulfur is an abundant, tasteless, odorless, multivalent non-metal. Sulfur, in its native form, is a yellow crystalline solid. In nature, it can be found as the pure element or as sulfide and sulfate minerals. It is an essential element for life and is found in two amino acids, cysteine and methionine. Sulfur is an essential component of all living cells. Sulfur may also serve as chemical food source for some primitive organisms: some forms of bacteria use hydrogen sulfide (H2S) in the place of water as the electron donor in a primitive photosynthesis-like process. Sulfur is absorbed by plants via the roots from soil as the sulfate ion and reduced to sulfide before it is incorporated into cysteine and other organic sulfur compounds (sulfur assimilation). In plants and animals the amino acids cysteine and methionine contain sulfur, as do all polypeptides, proteins, and enzymes which contain these amino acids. Glutathione is an important sulfur-containing tripeptide which plays a role in cells as a ...
An abbreviated summary is given below, indicating the number of tables in each category . Hydrocarbon Solvents ........................ 143 Halogenated Hydrocarbons .................... 64 Nitroparaffins .............................. 10 Organic Sulfur Compounds .................... 34 Mononhydric Alcohols ........................ 182 Polyhydric Alcohols .......................... 227 Phenols ................................... 1
Gentaur molecular products has all kinds of products like :search , Abfron \ anti-Carboxypeptidase N subunit 2 precusor , Mouse monoclonal to Carboxypeptidase N subunit 2 precusor , Isotype IgG1, Host Mouse \ LF-MA0203 for more molecular products just contact us
Equally impressive is the long list of diseases that have benefited from its use, including some that may not respond to other remedies, such as brain and spinal cord damage, Downs Syndrome, schizophrenia, and ALS (amyotrophic lateral sclerosis). It is able to dissolve blood clots and prevent damage after a stroke, improves skin conditions such as psoriasis and scleroderma, and is effective with autoimmune diseases, arthritis, ulcers, cystitis and other inflammatory conditions. With diabetes it can improve insulin control and blood circulation. Also eye problems have been successfully treated with DMSO, including macular degeneration, retinitis pigmentosa, glaucoma and cataracts, sometimes just with oral use but sometimes also with added remedies as eye drops.. DMSO is frequently used as a carrier in conventional chemotherapy or in antiviral therapy because of its ability to easily enter affected cells. With cancer it specifically zooms in on cancer cells and can be used to carry remedies ...
Agiltron product listing. Agiltron Incorporated is a manufacturer and developer of photonic components and systems. Agiltron leads the market in all optical switches, variable optical attenuators, high power optical components, optical polarization and time controls, PbS/PbSe infrared detectors, and Raman spectrometers.
EIIANtr is a member of a truncated phosphotransferase (PTS) system that serves regulatory functions and exists in many Proteobacteria in addition to the sugar transport PTS. In Escherichia coli, EIIANtr regulates K+ homeostasis through interaction with the K+ transporter TrkA and sensor kinase KdpD. In the β-Proteobacterium Ralstonia eutropha H16, EIIANtr influences formation of the industrially important bioplastic poly(3-hydroxybutyrate) (PHB). PHB accumulation is controlled by the stringent response and induced under conditions of nitrogen deprivation. Knockout of EIIANtr increases the PHB content. In contrast, absence of enzyme I or HPr, which deliver phosphoryl groups to EIIANtr, has the opposite effect. To clarify the role of EIIANtr in PHB formation, we screened for interacting proteins that co-purify with Strep-tagged EIIANtr from R. eutropha cells. This approach identified the bifunctional ppGpp synthase/hydrolase SpoT1, a key enzyme of the stringent response. Two-hybrid and far-Western
Optimization of a Microwave Assisted Extraction of Organic Sulphur from Domestic Sewage Sludge by UV-Vis Spectrophotometry Determination
An intracellular D(-)-3-hydroxybutyrate (3HB)-oligomer hydrolase gene from Ralstonia eutropha (formerly Alcaligenes eutrophus) H16 was cloned, sequenced, and characterized. As a hybridization probe to screen restriction digests of chromosomal DNA, an extracellular 3HB-oligomer hydrolase gene from Ra …
... is no safer during pregnancy than valproic acid. Valpromide is formed through the reaction of valproic acid and ... Valpromide (marketed as Depamide by Sanofi-Aventis) is a carboxamide derivative of valproic acid used in the treatment of ... It may produce more stable plasma levels than valproic acid or sodium valproate and may be more effective at preventing febrile ... It is rapidly metabolised (80%) to valproic acid (another anticonvulsant) but has anticonvulsant properties itself. ...
Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA), and impaired function ... "Exogenous γ-aminobutyric acid treatment affects citrate and amino acid accumulation to improve fruit quality and storage ... Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to ... Wei J, Davis KM, Wu H, Wu JY (May 2004). "Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 ...
However the strategy is limited by the fact that it requires a cysteine residue at N-terminus, an amino acid residue that is ... O-Linked glycans are formed by a linkage between an amino acid hydroxyl side chain (usually from serine or threonine) with the ... Shao N.; Xue J.; Guo Z. W. (2003). "Chemical synthesis of CD52 glycopeptides containing the acid-labile fucosyl linkage". ... Unlike standard SPPS (which is limited to 50 amino acid residue) NCL allows the construction of large glycopeptides. ...
Thebaine Tutin Ionotropic glutamate receptor agonists AMPA Domoic acid Kainic acid NMDA Quinolinic acid Quisqualic acid ... 2009 May 21;610(1-3):1-11. DOI 10.1016/j.ejphar.2009.03.025. PMID 19292981 Rubio C, Rubio-Osornio M, Retana-Márquez S, Verónica ... Pentetrazol Picrotoxin Sarmazenil Securinine Sinomenine Tetramethylenedisulfotetramine Thujone GABA synthesis inhibitors 3- ... Mercaptopropionic acid Allylglycine Glycine receptor antagonists Bicuculline Brucine Colubrine Diaboline Gelsemine Hyenandrine ...
... edetic acid MeSH D02.241.081.038.455 --- egtazic acid MeSH D02.241.081.038.581 --- iodoacetic acid MeSH D02.241.081.038.581.400 ... muramic acids MeSH D02.241.081.844.562 --- neuraminic acids MeSH D02.241.081.844.562.668 --- sialic acids MeSH D02.241.081.844. ... quinic acid MeSH D02.241.511.852 --- shikimic acid MeSH D02.241.511.902 --- sugar acids MeSH D02.241.511.902.107 --- ascorbic ... muramic acids MeSH D02.241.511.902.562 --- neuraminic acids MeSH D02.241.511.902.562.668 --- sialic acids MeSH D02.241.511.902. ...
... acrylic acid) copolymers polyelectrolyte, poly(methacrylic acid) (PMAA) etc. Gold nanoclusters have been synthesized with ... Poly(methacrylic acid)-stabilized nanoclusters have an excellent high quantum yield and can be transferred to other scaffolds ... The green-emitting gold nanoclusters can be synthesized by adding mercaptoundecanoic acid (MUA) into the prepared small gold ... The linear polyacrylates, poly(methacrylic acid), act as an excellent scaffold for the preparation of silver nanoclusters in ...
It has the amino acid sequence Mpa-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Mpa = β-mercaptopropionic acid), and is an analogue of ... oxytocin wherein the leading cysteine is replaced with β-mercaptopropionic acid. Carbetocin Merotocin TC OT 39 WAY-267,464 ... 389-. ISBN 978-1-60750-345-3. Tom K. A. B. Eskes; Mieczyslaw Finster (22 October 2013). Drug Therapy During Pregnancy. Elsevier ... 61-. ISBN 978-0-471-49637-3. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ...
... , or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ... By convention the term "amino acid", when used without a qualifier, refers specifically to an alpha amino acid. GABA is not an ... Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ...
Rindi, G; Ferrari, G (1959). "The γ-Aminobutyric Acid and Glutamic Acid Content of Brains of Rats treated with Toxopyrimidine ... Toxopyrimidine is a vitamin B6 antagonist with potent convulsant effects.[2][3] ... InChI=1S/C6H9N3O/c1-4-8-2-5(3-10)6(7)9-4/h2,10H,3H2,1H3,(H2,7,8,9) ...
Aspartic acid (aspartate). *DIDS. *Direct blue 71. *Erythro-4-methyl-L-glutamic acid ... 3Z,3'Z)-3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)di(1Z)hydrazin-2-yl-1-ylidene]bis(5-amino-4-oxo-3,4-dihydronaphthalene-2,7- ... It is a direct dye for cotton textiles.[3] In biosciences, it is used as vital stain to selectively colour dead tissues or ... Appendix 3. pp. Appendix 3B. doi:10.1002/0471142735.ima03bs21. ISBN 978-0471142737. PMID 18432654.. ...
... derived from the related proteinogenic L-amino acid glutamic acid. Theanine is an analog of this amino acid, and its primary ... Theanine /ˈθiːəniːn/, also known as L-γ-glutamylethylamide and N5-ethyl-L-glutamine, is an amino acid analogue of the ... to the amide formed from ethylamine and L-glutamic acid at its γ- (5-) side chain carboxylic acid group (as the name γ-L- ... Not to be confused with threonine, a distinct amino acid, or theine, an archaic synonym of caffeine. ...
Valerian constituents (e.g., valerenic acid). *Volatiles/gases (e.g., chloral hydrate, chloroform, diethyl ether, paraldehyde, ... ke-3. Sefiksim# · Seftriakson# · antipseudomonal (Seftazidim# · Sefoperazon) · Sefkapen · Sefdaloksim · Sefdinir · Sefditoren · ... Pada 1942, John Bumstead dan Orvan Hess menjadi ahli yang pertama berhasil menyembuhkan pasiennya dengan penisilin.[3][4] ...
R1-amino acid + R2-α-ketoacid ⇌ R1-α-ketoacid + R2-amino acid. A very common α-keto acid is α-ketoglutarate, an intermediate in ... Glutamic acid (symbol Glu or E)[4] is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins ... At pH values between about 2.5 and 4.1,[6] the carboxylic acid closer to the amine generally loses a proton, and the acid ... Glutamic acid is produced on the largest scale of any amino acid, with an estimated annual production of about 1.5 million tons ...
Another potential use involves capped single-crystal ZnO nanowires with CdSe quantum dots, immersed in mercaptopropionic acid ... Aromatic self-assembled monolayers (SAMs) (e.g. 4-nitrobenzoic acid) can be used to improve the band alignment at electrodes ... Ideallized image of colloidal nanoparticle of lead sulfide (selenide) with complete passivation by oleic acid, oleyl amine and ... nucleic acid aptamers,[55] or small-molecule ligands [56] can be used to target quantum dots to specific proteins on cells. ...
Mercaptopropionic acid; Propanoic acid, 3-mercapto-; «beta»-Thiopropionic acid; Hydracrylic acid, 3-thio-; Mercaptopropionic ... 2-Mercaptoethanecarboxylic acid; NSC 437; «beta»-Mercaptopropanoic acid; 3-Thiolpropanoic acid ... acid; Propionic acid, 3-mercapto-; 3-Thiopropionic acid; 3MPA; 3-Thiopropanoic acid; ... Food Chem., 1997, 45, 3, 898-906, https://doi.org/10.1021/jf960456t . [all data] ...
... mercaptopropionic acid (3 -MPA) has been chosen as a key study. The melting range has been determined to be: 16.7 °C to 18.1 °C ... mercaptopropionic acid, which are in the melting range determined in the key study. ... Two other available supporting studies (Lide, 2000 and Lewis, 1977) report the melting points (16.8 °C and 18 °C) for the 3 - ... Study performed in experimental laboratory (Paulus, 2008, LAUS) dedicated to estimate the melting point of the test material 3 ...
1-3 Dilution with water Formulation. Registration/ Notification status for the use:. use registered according to REACH Article ... ReleaseEnvirRep 3. Release from the site to::. non-agricultural soil. Release estimation method:. estimated release factor. ... PEC 3. Exposed compartment:. marine water. Exposure estimation method:. exposure estimation tool. Exposure estimation tool name ... 1-3 Dilution with water. Formulation. Contributing activity / technique for the environment. Environmental release category ( ...
SPION, Chromium, 3-Mercaptopropionic acid, Adsorption National Category Materials Chemistry Identifiers. URN: urn:nbn:se:su: ... The high Cr(VI) removal, rapid adsorption kinetics and stability of adsorbent indicate that 3-MPA coated SPION could be an ... Batch adsorption experiments showed that the functionalized adsorbent recovered 45 mg of Cr(VI)/g of 3-MPA coated SPION at ... Studies on the adsorption of chromium(VI) onto 3-Mercaptopropionic acid coated superparamagnetic iron oxide nanoparticles. ...
Page contains details about double-stranded DNA-bovine serum albumin/3-mercaptopropionic acid/CdS nanocrystal film . It has ... double-stranded DNA-bovine serum albumin/3-mercaptopropionic acid/CdS nanocrystal film. ...
Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA), and impaired function ... "Exogenous γ-aminobutyric acid treatment affects citrate and amino acid accumulation to improve fruit quality and storage ... Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to ... Wei J, Davis KM, Wu H, Wu JY (May 2004). "Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 ...
gamma-Aminobutyric acid, or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory ... Although in chemical terms, GABA is an amino acid (as it has both a primary amine and a carboxylic acid functional group), it ... By convention the term "amino acid", when used without a qualifier, refers specifically to an alpha amino acid. GABA is not an ... Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-γ-aminobutyric acid in normal and amino oxyacetic acid-treated ...
3-Mercaptopropionic acid. 2,2-Bipyridine-4,4-dicar.... 4,4-Dinonyl-2,2-bipyridine 2,4-Dibromothiazole. Ethyl, Cyano( ...
3-Mercaptopropionic acid. 2,2-Bipyridine-4,4-dicar.... 4,4-Dinonyl-2,2-bipyridine 2,4-Dibromothiazole. Ethyl, Cyano( ... Add : room 3-107, No.59 West WangAn Road,Jiangning District,Nanjing, Jiangsu,China. Zip code : 211103 Contact : Alan Chen Tel ...
Self-assembled monolayers (SAM) of 3-mercaptopropionic acid (MPA) were employed to covalently immobilize the anti-T-Tau (T-Tau ... A carbodiimide conjugation approach using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC) and N- ... Keywords: T-Tau protein detection; differential pulse voltammetry; [Fe(CN)6]3−/4− redox probe; 3-mercaptopropionic acid (MPA) T ... Self-assembled monolayers (SAM) of 3-mercaptopropionic acid (MPA) were employed to covalently immobilize the anti-T-Tau (T-Tau ...
... mercaptopropionic Acid Food Grade Amino Acids L-Cysteine C3H7NO2S products at lowest price, view more (R)-2-Amino-3 - ... mercaptopropionic Acid Food Grade Amino Acids L-Cysteine C3H7NO2S products from WUHAN SOLEADO TECHNOLOGY CO.,LTD. of 90045569 ... mercaptopropionic Acid Food Grade Amino Acids L-Cysteine C3H7NO2S and more.. USP standard Food Grade Amino Acids L-Serine for ... L D Amino Acids Medicine grade amino acid L-glutamine Full name: L-glutamine Other names: (S)-2,5-Diamino-5-oxopentanoic acid ...
β-mercaptopropionic acid (Meb) was added as the last step in the synthesis to yield the intermediate product MP(Meb)-Pro-Gly- ... β-Mercaptopropionic acid-resin (compound III) can be used in the synthesis of peptides with an N-terminal sulfhydryl group. ... The β-mercaptopropionic acid-resin provides peptides containing an N-terminal free sulfhydryl group through which the peptide ... acid in dichloro-. methane or 33% HBr. in acetic acid. 3b 50% Trifluoroacetic. 50 30.0/60.0. 1. acid in dichloro-. methane or ...
Propanoic Acid, 2-amino-3-mercapto-, (R)-; Thioserine; (R)-2-Amino-3-mercaptopropanoic acid; «alpha»-Amino-«beta»- ... Other names: Cysteine, L-; «beta»-Mercaptoalanine; Cystein; Cysteine; Half-cystine; L-(+)-Cysteine; L-Alanine, 3-mercapto-; NSC ... InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m1/s1 ... 2-Amino-3-mercaptopropionic acid; L-Cys *Information on this ...
In general, these methods comprise the sequential addition of one or more amino acids, or suitably protected amino acids, to a ... The protecting group is then removed from this newly added amino acid residue and the next amino acid (suitably protected) is ... Aqueous workup converts the terminal acid chloride to a carboxylic acid. This product is analogous to 6-carboxyfluorescein, and ... cysteine amino acids, which are separated by 1-2 amino acids. The reaction involves a bi-displacement reaction to form a cyclic ...
Indicaciones de precaución: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
Minsang Lee; Melinda N Martin; Andre O Hudson; Jiyeon Lee; Michael J Muhitch; Thomas Leustek. Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana. Plant Journal.2005, 41, (5), 685-696.. S Ravanel; M Droux; R Douce. Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts. Archives of Biochemistry and Biophysics.1995, 316, (1), 572-584.. ...
A. Khan, "Preparation and characterization of N-isopropylacrylamide/acrylic acid copolymer core-shell microgel particles," ... O double-bond stretching vibration in the carboxylic acid groups bound to the CdS particles. The peaks at 1655 and 1553 cm−1 ... In the first step, 2.5 mmol of cadmium chloride monohydrate (CdCl2·H2O) was dissolved in 3 mL of deionized water. The cadmium ... Figure 3: Typical transmission electron microscopy image of CdS NPs dispersed in DMF. Scale bar represents 50 nm. Inset: SAED ...
Aminooxyacetic acid (C13408). α-Ketoglutarate (m) (K1750). │ │---------------→. ↓. Dicarboxylate carrier. Malate (02300). ... Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Acetylenic GABA (A230). GABA (A2129). │ │---------------→. │ ... Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Vinyl GABA (V8261). GABAculine (A3539). ... However, in the case of the carbonyl-trapping agent aminooxyacetic acid its Ki value for inhibition of GABA-transaminase is 10- ...
3-MPA family. Justifications and discussions. Category definition:. 3-Mercaptopropionic acid, and its esters. Category ... 2,4,6-trioxo-1,3,5-triazine-1,3,5(2H,4H,6H)-triyl)triethane-2,1-diyl tris(3-mercaptopropionate). ...
limonene dimercaptan and the tetra ester of pentaerythritol and beta-mercapto-propionic acid. ... peracetic acid. and perphthalic acid; the per-salt catalysts such as potassium persulfate. the peroxide catalysts such as ... 4-dithiobis-anthranilic acid Z-benzimidazolethiol o-mercapto-benzoic acid 2,2-dithiobis-benzothiazole Z-benzothiazolethiol ... The tetra ester of pcntacrythritol and hcta-mcrcaptu-propiunic acid having the formula C- CH -O-C-CH CH Initially. 0.05 part of ...
Citric acid monohydrate ..... 1.7 mg. Disodium phosphate dihydrate ..... 3.0 mg. Benzalkonium chloride solution (50%) ..... 0.2 ... For children aged 3 months to 12 years, the usual dosage range is 0.05 to 0.3 mL daily, either as a single dose or divided into ... 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt) trihydrate.. DDAVP Nasal Spray (desmopressin acetate ... About 1/4 to 1/3 of patients can be controlled by a single daily dose of DDAVP administered intranasally. Fluid restriction ...
At the other end, a deprotonated carboxylic acid group and/or amine group provided enough electrostatic repulsion to yield ... negatively-charged mercaptopropionic ligand-coated QDs (MPA-CdTe), and zwitterionic cysteine coated QDs (Cys-CdTe), as shown in ... FIGURE 3. Figure 3. Core-shell QDs for improved stability. (A) Normalized emission spectra of QDs over time in PBS during ... Yuchen Ding2,3, Colleen M. Courtney1, Partha P. Chowdhury1,2, Annette Erbse3, Anushree Chatterjee1 and Prashant Nagpal1,2,4* ...
Lab Nucleic Acid Purification Equipment *Nucleic Acid Purification Instruments. *Nucleic Acid Purification Accessories ... 3-Mercaptopropyl)trimethoxysilane TCI-M0928 , 4420-74-0 , C6H16O3SSi , TCI America (3-Mercaptopropyl)trimethoxysilane ... Ethyl 3-Mercaptopropionate TCI-M1038 , 5466-06-8 , C5H10O2S , TCI America Ethyl 3-Mercaptopropionate ... 3-Mercaptopropionic Acid TCI-M0061 , 107-96-0 , C3H6O2S , TCI America 3-Mercaptopropionic Acid ...
16(a) and (b)).39,216 High-resolution STM images of a mixed-ligand layer (e.g., octanethiol and mercaptopropionic acid) on Au ... The yellow lobes represent octanethiols and the red lobes represent mercaptopropionic acids.217 Reprinted with permission from ... c) STM image of octanethiol/mercaptopropionic acid mixed layer-protected Au NPs. The ligand shell shows phase separated ordered ... Au NPs surrounded by citric acids are negatively charged; thus, they selectively adsorb onto a positively charged surface ...
The ToxT protein is 276 amino acids in length, with the 100-amino-acid AraC/XylS family domain at its C-terminal end (17). The ... The function of the remaining 176 amino acids of ToxT, which presumably form a second domain, is unknown, and this domain has ... 3.↵. Brown, R. C., and R. K. Taylor. 1995. Organization of tcp, acf, and toxT genes within a ToxT-dependent operon. Mol. ... 2 and 3]). Based on our observations of the requirements for ToxT-directed transcription of acfA, acfD (59), tagA, tcpA (J. H. ...
  • By the addition of sodium borohydride as a reducing agent into an aqueous solution of AgNO 3 mixed with 3-mercapto-propionic acid as a protective agent, nano-sized Ag metal particles could be synthesized. (brillonline.com)
  • Using this advanced wet-process the synthesis of an aqueous Ag colloid system with a high density became possible, because the surfaces of the synthesized nano-sized Ag metal particles were covered and protected by the adsorbed 3-mercapto-propionic acid. (brillonline.com)
  • a higher 3-mercapto-propionic acid/AgNO 3 ratio was preferable in the synthesis of smaller Ag metal particles. (brillonline.com)
  • From the relationship between the Ag metal particle size and the residual S content adsorbed on the metal particles, the mechanism of dispersion of Ag particles can be proposed as that the 3-mercapto-propionic acid having a thiol group adsorbs on Ag particles by forming Ag-S bonds as a protective agent. (brillonline.com)
  • Abstract: For the synthesis of the nano-sized Ag metal particle, the sodium borohydride for the reducing agent was added into the aqueous solution of the AgNO3 with 3-mercapto-propionic acid as protective agent. (scientific.net)
  • Because the surface of nano-sized Ag metal particle was protected by the adsorbed 3-mercapto-propionic acid, the synthesis of the aqueous colloid system with high density became possible. (scientific.net)
  • By changing the quantity of the agent of propionic acid and the pH value of solution, the particle size can be controlled optionally in the range of 50~200 nm. (scientific.net)
  • The enzyme immobilization is done on a planar gold gate electrode using 3-mercapto propionic acid as the linker molecule. (tum.de)
  • First, BHb MIPs were successfully synthesized with magnetic Fe 3 O 4 @Au nanoparticles as carrier by surface modification of mercapto propionic acid for introducing carboxyl groups, combined with dopamine as the functional monomer and BHb as the template protein. (go.jp)
  • For the successful removal of Cr(VI), we demonstrate a novel adsorbent consisting of superparamagnetic iron oxide nanoparticles (SPION) functionalized with 3-Mercaptopropionic acid (3-MPA). (diva-portal.org)
  • The CdS nanoparticles were prepared at room temperature from cadmium chloride and sodium sulfide salts in the presence of an organic ligand, 3-mercaptopropionic acid (MPA). (hindawi.com)
  • We researched the influence of 3-MPA on the nanoparticles formation by ionic gelation method using sodium tripolyphosphate (TPP) as cross-linker reagent. (hindawi.com)
  • Monomer methacrylic acid molecules were absorbed onto the synthesized ferrimagnetic nanoparticles followed by polymerization. (mit.edu)
  • We report herein two methods to characterize the surface of mixed-ligand shell gold nanoparticles, which was explored with gold nanoparticles containing varying molar ratios of 3-mercaptopropionic acid (MPA) and 3-mercapto-1-propanesulfonate (MPS) or 11-mercaptoundecanoic acid (MUA) and triethylene glycol mono-11-mercaptoundecyl ether (TEG) in their ligand shell. (rsc.org)
  • Incubation of gold nanoparticles with a solution containing the transition metal cation Ni 2+ allows the extraction of Ni 2+ depending on the number of negatively charged surface groups and the reaction of surface carboxylic acid groups with an aminomethyladamantane derivative allows the extraction of the supramolecular host molecule cucurbituril (CB7) depending on the number of reactive surface groups. (rsc.org)
  • The supramolecular CB7 assay enabled the determination of the accessible ligand density of reactive surface carboxylic acid groups and revealed a striking difference in the number of surface groups that can be reacted with MPA/MPS gold nanoparticles or MUA/TEG gold nanoparticles, which suggests a simple method to probe the surface structure of mixed monolayer gold nanoparticles. (rsc.org)
  • In this paper, we report a new class of Type 3 porous liquids based on rational coupling of microporous framework nanoparticles as porous hosts with a bulky ionic liquid as the fluid media. (osti.gov)
  • Embodiments of a method for using nucleic acid molecules to control the growth and shape of nanoparticles are disclosed, as well nanoparticles and methods of using such nanoparticles. (rexresearch.com)
  • For the construction of the sensor, the surface of a graphite screen-printed electrode is modified with electrodeposited gold nanoparticles followed by self-assembling a monolayer of 3-mercaptopropionic acid on the electrode surface. (deepdyve.com)
  • Nanoparticles as nucleic acid delivery vectors -- 3. (stanford.edu)
  • Nanoparticles for locked nucleic acid delivery -- 7. (stanford.edu)
  • Acidic impurities in dihydroxyaromatic compounds such as bisphenol A, as illustrated by sulfonic acids and mercaptocarboxylic acids, can have an adverse effect on the molecular weight of a polycarbonate prepared therefrom by transesterification. (patentgenius.com)
  • The time courses of glucose and fructose, acetaldehyde, several organic acids, and nitrogenous compounds were measured along with the final values of other key wine parameters. (asm.org)
  • No statistically significant differences were found with regard to the final values of pH or total acidity and the concentrations of ethanol, acetaldehyde, glycerol, citric and lactic acids, and the nitrogen compounds arginine, ammonia, urea, citrulline, and ornithine. (asm.org)
  • Several IMP-1 inhibitors such as thiol compounds including 2-mercaptopropionic acid, heavy metal salts, and EDTA were evaluated for this test. (asm.org)
  • Provided the monosaccharide amino acid building block is stable to peptide coupling conditions, amine deprotection conditions and resin cleavage. (wikipedia.org)
  • Fe(II), 3 ), where H 2 RSSR is a reduced Schiff base derived from 2-(thioethyl)salicylaldimine having a disulphide moiety and H 2 PDS is derived from dimerization of D-penicillamine, have been prepared, structurally characterized, and their photo-induced DNA cleavage activity studied. (ias.ac.in)
  • Complexes 1-3 do not show any DNA cleavage activity in darkness. (ias.ac.in)
  • In the presence of a reducing agent like 3-mercaptopropionic acid, 1 produces significant oxidative DNA cleavage, whereas 2 is inactive. (bireme.br)
  • C) establishing the level of sodium hydroxide in the polycarbonate-forming reaction mixture at a value which is at most 1 molar ppm, based on bisphenol A, in excess of that of said sulfonic acids. (patentgenius.com)
  • Oxidation of cysteine can produce a disulfide bond with another thiol and further oxidation can produce sulphfinic or sulfonic acids. (hmdb.ca)
  • In this study, commercially available granular activated carbon (GAC) was modified with 0.3 M citric acid to get citric acid modified GAC (CAGAC). (bvsalud.org)
  • The leaching behavior of five additives, including citric acid (CA), wood vinegar (WV), 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), polyaspartic acid (PASP) and FeCl3, was investigated to evaluate the possibility of enhanced phytoextraction of Pennisetum sp. (bvsalud.org)
  • The present study deals with the potential application of Purolite S957 and Diphonix Resin® for the removal of rare earth elements from aqueous liquors as a result of the extraction of spent Ni-MH batteries in the presence of citric acid. (bvsalud.org)
  • The effects of the metal ion and the citric acid ratio, pH, ion exchanger dose, contact time, initial concentration and temperature were studied using the batch technique. (bvsalud.org)
  • This study investigated the direct citric acid hydrolysis extraction method to optimize phytosterols extraction from hickory husk. (bvsalud.org)
  • CO2 with 9% extract of Saponaria officinalis root and glycerol, xanthan gum, alkyl polyglycoside, Na benzoate and citric acid and studied for rheol. (sigma-not.pl)
  • Chromatographic separation was achieved on a Platisil C18 column (150 × 4.6 mm, 5 μm) using methanol-0.01% formic acid (70:30, v/v) as the mobile phase at a flow rate of 0.6 mL/min under an isocratic condition. (go.jp)
  • Rates of electron transfer reaction of thioglycolic acid with vanadium(V) substituted Keggintype heteropolyanion, [PV V V V W 10 O 40 ] 5- , in acetate-acetic acid buffers have been measured spectrophotometrically at 25°C. The order of the reaction with respect to substrate and oxidant is unity. (ias.ac.in)
  • While acetic acid concentrations were slightly increased in wines after simultaneous AF/MLF, the differences were of neither practical nor legal significance. (asm.org)
  • A sensor is a self-contained device that integrates an immobilized element (e.g. enzyme, pesticide, antibiotics, ascorbic acid, DNA probe and antibody) that can recognize the analyte (e.g. enzyme substrate, antigen and complementary DNA) and different transduction element [ 2 ]. (omicsonline.org)
  • However, there is also some use in consumer products, [email protected] e.g. several thousand tons per year of thioglycolic acid and its 1 salts go into cosmetic and cleaning formulations and are there- Institute of Sustainable and Environmental Chemistry, Leuphana fore released to the environment directly or indirectly via sew- University Lüneburg, Universitätsallee 1, 21335 Lüneburg, Germany 2 age treatment plants. (deepdyve.com)
  • C) establishing the level of alkali metal hydroxide in the polycarbonate-forming reaction mixture at a value which is at most 1 molar ppm, based on dihydroxyaromatic compound, in excess of that of at least one of sulfonic acid,mercaptocarboxylic acid, salicylic acid and ferric chloride. (patentgenius.com)
  • 3. A method according to claim 1 wherein the dihydroxyaromatic compound is bisphenol A. 4. (patentgenius.com)
  • A 1,2-unsaturated carboxylic acid or its ester such as acrylic or methacrylic acid or its alkyl ester is purified to remove aldehyde impurities contained therein by treating the acid or its ester with a mercapto containing compound in the presence of an acid catalyst. (google.com.au)
  • 5. The process as claimed in claim 1, in which the 1,2-unsaturated carboxylic acid is acrylic acid and the mercaptan compound is an alkylmercaptan having a boiling temperature not lower than approximately 270 C. (google.com.au)
  • 7. The process as claimed in claim 6 in which the 1,2-alkenoic acid and/or ester is treated with the mercaptan compound in an amount of from equimole to 10 fold moles of the total molar amount of the aldehyde impurities. (google.com.au)
  • 9. The process as claimed in claim 1, in which the 1,2-alkenoic unsaturated acid and/or ester is treated with the mercaptan compound at a temperature of 25 to 90 C. (google.com.au)
  • All these facts have boosted interest for this family of materials with a general formula ABX 3 (A = organic cation, B = metallic cation, and X = halide anion, where CH 3 NH 3 PbI 3 has been the most extensively studied). (sciencemag.org)
  • Poly(acrylic acid) (PAA) was attached on both termini of Pluronic P85 copolymer (EO27PO39EO27)) via atom transfer radical polymerization (ATRP) to produce a novel block copolymer, PAA-b-P85-b-PAA (P85PAA). (mit.edu)
  • A double-disc synergy test (DDST) and 2-mercaptopropionic acid inhibition test (2-MPAT) were used to confirm beta-lactamase-producing isolates. (nih.gov)
  • Inoculating grape musts with wine yeast and lactic acid bacteria (LAB) concurrently in order to induce simultaneous alcoholic fermentation (AF) and malolactic fermentation (MLF) can be an efficient alternative to overcome potential inhibition of LAB in wines because of high ethanol concentrations and reduced nutrient content. (asm.org)
  • 2. The process according to claim 1, in which the 1,2-alkenoic acid is selected from the group consisting of acrylic acid and methacrylic acid. (google.com.au)
  • This is particularly serious for aminooxyacetic acid, which at high concentrations will inhibit all pyridoxal phosphate-dependent enzymes. (sigmaaldrich.com)
  • Pharmaceutical intermediate N-Acetyl-L-Tyrosine Amino Acid Dipeptide C11H13NO4 English name: N-Acetyl-L-Tyrosin CAS No.: 537-55-3 Molecular formula: C11H13NO4 Molecular Weight: 223. (everychina.com)
  • Nutraceutical Ingredients Dietary supplement ingredient amino acid L-Citrulline AJI92 English name: L-CitrullineCAS No :372-75-8Molecular formula: C6H13N3O3 Molecular Weight: 175. (everychina.com)
  • Pharmaceutical raw material amino acid L-Aspartic acid AJI97 Food Grade Amino Acids CAS No. 70-47-3, Structural Formula: Molecular Formula:C4H10N2O4 Molecular Weight:150.13 L. (everychina.com)
  • Because toxT is also located within the large tcpA operon ( 3 , 16 ), once ToxT protein has been produced it is able to activate its own expression through a positive-feedback loop ( 61 ). (asm.org)
  • Phylogeny of the Vitamin K 2,3-Epoxide Reductase (VKOR) Family and Evolutionary Relationship to the Disulfide Bond Formation Protein B (DsbB) Family. (nih.gov)
  • There is currently a huge amount of interest in the possibility of protein or nucleic acid markers reliably reporting on disease onset many years before patients become symptomatic. (omicsonline.org)
  • Although a diverse range of markers have been studied, including glycoproteins (specially for cancer detection [ 4 ]) and monocytes [ 5 , 6 ] (associated to bacterial infection), this review will be focused to a consideration of nucleic acid and protein markers specifically. (omicsonline.org)
  • 2008). Consequently, soybean meal is a valuable and desirable product for both human nutrition and livestock feeding, since it contains all essential amino acids and has low cost compared to other high-quality protein sources. (scielo.br)
  • Batch adsorption experiments showed that the functionalized adsorbent recovered 45 mg of Cr(VI)/g of 3-MPA coated SPION at initial concentration of 50 mg/L aqueous solution at pH 1 with less than 1% of Fe dissolution from SPION. (diva-portal.org)
  • Pharmaceutical raw material Food Grade Amino Acids L-Histidine for biochemical reagents Abbreviation: L-His CAS Number: 71-00-1 Conforms To: USP, EP Chemical Name: (S)-2-Amino -1H. (everychina.com)
  • Glycopeptides are peptides that contain carbohydrate moieties (glycans) covalently attached to the side chains of the amino acid residues that constitute the peptide. (wikipedia.org)
  • Stimuli-responsive materials used as medical devices in loading and releasing of drugs -- 3. (stanford.edu)
  • Magnetic multi-walled carbon nanotubes (M-MWCNTs) were coated with a layer formed through the hydrolysis and condensation of 3-mercaptopropyltriethoxysilane (MPTS). (mdpi.com)
  • Jiang X, Xiao L, Ai X, Yang H, Cao Y (2017) Novel bifunctional thermo-sensitive poly(lactic acid)@poly(butylene succinate) core-shell fibrous separator prepared by coaxial electrospun route for safe lithium-ion battery. (springer.com)
  • The objective of this work was to perform a quantitative analysis of the amino acid composition of soybean seeds as affected by climatic variables during seed filling. (scielo.br)
  • Therefore, the study of soybean amino acid composition is important for nutritional purposes and for consumer acceptance of soy food products, as it contributes to the taste of foodstuffs (Gao et al. (scielo.br)
  • The same is true of acidic impurities in diaryl carbonates such as diphenyl carbonate, as illustrated by salicylic acid and ferric chloride. (patentgenius.com)
  • 3. The method according to claim 1 wherein the synthesized peptide is cyclized by oxidizing sulfhydryl groups to form intramolecular disulfide bonds. (freepatentsonline.com)
  • Figure 21.2.2 Detection of cystic fibrosis transmembrane conductance regulator (CFTR) activity using 6-methoxy- N -(3-sulfopropyl)quinolinium, inner salt (SPQ, M440 ). (thermofisher.com)