3-Mercaptopropionic Acid: An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.Myoclonus: Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).Alcaligenaceae: A family of gram-negative, aerobic, non-spore forming rods or cocci. Well known genera include ACHROMOBACTER; ALCALIGENES; and BORDETELLA.Propionates: Derivatives of propionic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxyethane structure.Carnitine O-Acetyltransferase: An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1.7.Sulfhydryl Compounds: Compounds containing the -SH radical.Palmitoylcarnitine: A long-chain fatty acid ester of carnitine which facilitates the transfer of long-chain fatty acids from cytoplasm into mitochondria during the oxidation of fatty acids.Acetyl-CoA C-Acyltransferase: Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is formed.Allyl CompoundsAcyl-CoA Dehydrogenases: Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS.Pyridoxine: The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."Papio: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.
(1/62) Specific adhesion of vesicles monitored by scanning force microscopy and quartz crystal microbalance.

The specific adhesion of unilamellar vesicles with an average diameter of 100 nm on functionalized surfaces mediated by molecular recognition was investigated in detail. Two complementary techniques, scanning force microscopy (SFM) and quartz crystal microbalance (QCM) were used to study adhesion of liposomes consisting of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine and varying concentrations of N-((6-biotinoyl)amino)hexanoyl)-1, 2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (biotin-X-DHPE). Monitoring the adhesion of the receptor-doped vesicles to avidin-coated gold surfaces by QCM (f(0) = 5 MHz) revealed an increased shift in resonance frequency with increasing biotin concentration up to 10 mol% biotin-X-DHPE. To address the question of how the morphology of the liposomes changes upon adhesion and how that contributes to the resonator's frequency response, we performed a detailed analysis of the liposome morphology by SFM. We found that, with increasing biotin-concentration, the height of the liposomes decreases considerably up to the point where vesicle rupture occurs. Thus, we conclude that the unexpected high frequency shifts of the quartz crystal (>500 Hz) can be attributed to a firm attachment of the spread bilayers, in which the number of contacts is responsible for the signal. These findings are compared with one of our recent studies on cell adhesion monitored by QCM.  (+info)

(2/62) Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma.

Because bradykinin (BK) appears to have cardioprotective effects ranging from improved hemodynamics to antiproliferative effects, inhibition of BK-degrading enzymes should potentiate such actions. The purpose of this study was to find out which enzymes are responsible for the degradation of BK in human plasma. Human plasma from healthy donors (n = 10) was incubated with BK in the presence or absence of specific enzyme inhibitors. At high (micromolar) concentrations, BK was mostly (>90%) degraded by carboxypeptidase N (CPN)-like activity. In contrast, at low (nanomolar) substrate concentrations, at which the velocity of the catalytic reaction is equivalent to that under physiological conditions, BK was mostly (>90%) converted into an inactive metabolite, BK-(1-7), by angiotensin-converting enzyme (ACE). BK-(1-7) was further converted by ACE into BK-(1-5), with accumulation of this active peptide. A minor fraction (<10%) of the BK was converted into another active metabolite, BK-(1-8), by CPN-like activity. The present study shows that the most critical step in plasma kinin metabolism, i.e., inactivation of BK, is mediated by ACE. Thus inhibition of plasma ACE activity would be cardioprotective by elevating the concentration of BK in the circulation.  (+info)

(3/62) Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic rats.

1. The successive effects of the angiotensin-converting enzyme inhibitor captopril (CAP, 2 mg kg(-1)+1 mg kg(-1) 30 min(-1) infusion) and the neutral endopeptidase 24-11 inhibitor retrothiorphan (RT, 25 mg kg(-1)+12.5 mg kg(-1) 30 min(-1) infusion) were studied on femoral vascular conductance (FVC) in streptozotocin-induced diabetic (STZ-SD) and control Sprague-Dawley (C-SD) rats. The role of the kinin-nitric oxide (NO) pathway was assessed by (1) using pre-treatments: a bradykinin (BK) B2 receptor antagonist (Hoe-140, 300 microg kg(-1)), a NO-synthase inhibitor (N(omega)-nitro-L-arginine methyl ester, L-NAME, 10 mg kg(-1)), a kininase I inhibitor (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, MGTA, 10 mg kg(-1)+20 mg kg(-1) 20 min(-1) infusion) and (2) comparing the effects in STZ-induced diabetic (STZ-BN) and control Brown-Norway kininogen-deficient (C-BN) rats. 2. In C-SDs, CAP and CAP+RT increased FVC similarly. In STZ-SDs, FVC and FBF were decreased compared to C-SDs. CAP+RT increased them more effectively than CAP alone. 3. In both C-SDs and STZ-SDs, the femoral bed vasodilatation elicited by CAP was inhibited by Hoe-140 and L-NAME. The FVC increase elicited by CAP+RT was not significantly reduced by Hoe-140 but was inhibited by L-NAME and Hoe-140+MGTA. 4. In C-BNs, the vasodilatator responses to CAP and CAP+RT were abolished and highly reduced, respectively. In STZ-BNs, these responses were abolished. 5. These results show that in STZ-SDs, CAP+RT improve FBF and FVC more effectively than CAP alone. These effects are linked to an increased activation of the kinin-NO pathway. BK could lead to NO production by BK B2 receptor activation and another pathway in which kininase I may be involved.  (+info)

(4/62) Persistent activation of GABA(A) receptor/Cl(-) channels by astrocyte-derived GABA in cultured embryonic rat hippocampal neurons.

Whole cell patch-clamp recordings using Cl(-)-filled pipettes revealed more negative levels of baseline current and associated current variance in embryonic rat hippocampal neurons co-cultured on a monolayer of astrocytes than those cultured on poly-D-lysine. These effects were mimicked by culturing neurons on poly-D-lysine in astrocyte-conditioned medium (ACM). The baseline current and variance decreased immediately in all cells after either local perfusion with saline or exposure to bicuculline, an antagonist of GABA at GABA(A) receptor/Cl(-) channels. Baseline current and variance in all cells reached a nadir at approximately 0 mV, the calculated equilibrium potential for Cl(-). Perfusion of ACM rapidly induced a sustained current in neurons, which also reversed polarity at approximately 0 mV. Bicuculline attenuated or eliminated the ACM-induced current at a concentration that completely blocked micromolar GABA-induced current. Quantitative analyses of spontaneously occurring fluctuations superimposed on the ACM-induced current revealed estimated unitary properties of the underlying channel activity similar to those calculated for GABA's activation of GABA(A) receptor/Cl(-) channels. Bicuculline-sensitive synaptic-like transients, which reversed at approximately 0 mV, were also detected in neurons cultured in ACM, and these were immediately eliminated along with the negative baseline current and superimposed current fluctuations by perfusion. Furthermore bicuculline-sensitive synaptic-like transients were rapidly and reversibly triggered when ACM was acutely applied. ACM induced an increase in cytoplasmic Ca(2+) in cultured embryonic hippocampal neurons that was completely blocked by bicuculline and strychnine. We conclude that astrocytes release diffusible substances, most likely GABA, that persistently activate GABA(A) receptor/Cl(-) channels in co-cultured neurons.  (+info)

(5/62) Identification of a new class of biopolymer: bacterial synthesis of a sulfur-containing polymer with thioester linkages.

This is the first report on the biosynthesis of a hitherto unknown, sulfur-containing polyester and also the first report on a bacterial polymer containing sulfur in the backbone. The Gram-negative polyhydroxyalkanoate (PHA)-accumulating bacterium Ralstonia eutropha synthesized a copolymer of 3-hydroxybutyrate and 3-mercaptopropionate, poly(3HB-co-3MP), when 3-mercaptopropionic acid or 3,3'-thiodipropionic acid was provided as carbon source in addition to fructose or gluconic acid under nitrogen-limited growth conditions. The peculiarity of this polymer was the occurrence of thioester linkages derived from the thiol groups of 3MP and the carboxyl groups of 3MP or 3HB, respectively, which occurred in addition to the common oxoester bonds of PHAs. Depending on the cultivation conditions and the feeding regime, poly(3HB-co-3MP) contributed up to 19% of the cellular dry weight, with a molar fraction of 3MP of up to 43%. The chemical structure of poly(3HB-co-3MP) was confirmed by GC/MS, IR spectroscopy, (1)H- and (13)C-NMR spectroscopy, and elemental sulfur analysis. The identification of this novel biopolymer reveals a new quality regarding the substrate range of PHA synthases and their capability for the synthesis of technically interesting polymers.  (+info)

(6/62) Plasticity of rat central inhibitory synapses through GABA metabolism.

1. The production of the central inhibitory transmitter GABA (gamma-aminobutyric acid) varies in response to different patterns of activity. It therefore seems possible that GABA metabolism can determine inhibitory synaptic strength and that presynaptic GABA content is a regulated parameter for synaptic plasticity. 2. We altered presynaptic GABA metabolism in cultured rat hippocampal slices using pharmacological tools. Degradation of GABA by GABA-transaminase (GABA-T) was blocked by gamma-vinyl-GABA (GVG) and synthesis of GABA through glutamate decarboxylase (GAD) was suppressed with 3-mercaptopropionic acid (MPA). We measured miniature GABAergic postsynaptic currents (mIPSCs) in CA3 pyramidal cells using the whole-cell patch clamp technique. 3. Elevated intra-synaptic GABA levels after block of GABA-T resulted in increased mIPSC amplitude and frequency. In addition, tonic GABAergic background noise was enhanced by GVG. Electron micrographs from inhibitory synapses identified by immunogold staining for GABA confirmed the enhanced GABA content but revealed no further morphological alterations. 4. The suppression of GABA synthesis by MPA had opposite functional consequences: mIPSC amplitude and frequency decreased and current noise was reduced compared with control. However, we were unable to demonstrate the decreased GABA content in biochemical analyses of whole slices or in electron micrographs. 5. We conclude that the transmitter content of GABAergic vesicles is variable and that postsynaptic receptors are usually not saturated, leaving room for up-regulation of inhibitory synaptic strength. Our data reveal a new mechanism of plasticity at central inhibitory synapses and provide a rationale for the activity-dependent regulation of GABA synthesis in mammals.  (+info)

(7/62) Chiral separation by electrokinetic capillary chromatography using newly synthesized linear polymers containing L-amino acid moieties.

Chiral linear polymers were prepared by the thermal polymerization of N-acryloyl-L-valine and N-acryloyl-L-alanine derivatives using 3-mercaptopropionic acid (3-MPA) as a radical transfer agent. C-Terminal groups of the derivatives were methyl and tert-butyl esters later removed, and N-methylamide moieties. The N'-methylamide derivative of N-acryloyl-L-valine was copolymerized with methyl ester at a molar mixing ratio of 1:1. The ester groups were removed to provide anionic linear polymers terminated with carboxylic acid of the amino acid residue. The polymers are thus shown to function as pesudostationary phases that separate enantiomeric solutes in electrokinetic capillary chromatography (EKC). Racemic 3,5-dinitrobenzoylamino isopropyl esters were separated with the polymer derived from N-acryloyl-L-valine esters and with the copolymer from N-acryloyl-L-valine methyl ester and N-acryloyl-L-valine N'-methylamide at pH 7.0. These separations could not be observed at pH 9.0 in migrating solutions containing anionic linear polymers. This pH dependence can be discussed from the standpoint of the microscopic hydrophobicity of the polymers, as assessed from the fluorescence of pyrene adsorbed onto the polymers in water.  (+info)

(8/62) Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis.

Arginine carboxypeptidase was isolated from the cytoplasm of Porphyromonas gingivalis 381 and purified by DEAE-Sephacel column chromatography, followed by high-performance liquid chromatography on DEAE-5PW and TSK G2000SW(XL). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified enzyme revealed the presence of three major bands at 42, 33, and 32 kDa with identical N-terminal sequences. By Western blotting analysis and immunoelectron microscopy, the arginine carboxypeptidase was found to be widely distributed in the cytoplasm and on the surface of the outer membrane. The open reading frame corresponding to the N-terminal amino acids of the arginine carboxypeptidase was detected by a search of the sequence of the P. gingivalis W83 genome. This sequence showed homology with mammalian carboxypeptidases (M, N, and E/H) and included a zinc-binding region signature, suggesting that the enzyme is a member of the zinc carboxypeptidase family. The purified enzyme was inhibited by EGTA, o-phenanthroline, DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, and some metal ions, such as Cu(2+), Zn(2+), and Cd(2+). On the other hand, Co(2+) activated the enzyme. The enzyme released arginine and/or lysine from biologically active peptides containing these amino acids at the C terminus but did not cleave substrates when proline was present at the penultimate position. These results indicate that the arginine carboxypeptidase produced by P. gingivalis is an exo type of metallocarboxypeptidase. This enzyme may function to release arginine in collaboration with an arginine aminopeptidase, e.g., Arg-gingipain, to obtain specific amino acids from host tissues during the growth of P. gingivalis.  (+info)

*  Glycopeptide
However the strategy is limited by the fact that it requires a cysteine residue at N-terminus, an amino acid residue that is ... O-Linked glycans are formed by a linkage between an amino acid hydroxyl side chain (usually from serine or threonine) with the ... Shao N.; Xue J.; Guo Z. W. (2003). "Chemical synthesis of CD52 glycopeptides containing the acid-labile fucosyl linkage". ... Unlike standard SPPS (which is limited to 50 amino acid residue) NCL allows the construction of large glycopeptides. ...
*  Convulsant
Thebaine Tutin Ionotropic glutamate receptor agonists AMPA Domoic acid Kainic acid NMDA Quinolinic acid Quisqualic acid ... 2009 May 21;610(1-3):1-11. DOI 10.1016/j.ejphar.2009.03.025. PMID 19292981 Rubio C, Rubio-Osornio M, Retana-Márquez S, Verónica ... Pentetrazol Picrotoxin Sarmazenil Securinine Sinomenine Tetramethylenedisulfotetramine Thujone GABA synthesis inhibitors 3- ... Mercaptopropionic acid Allylglycine Glycine receptor antagonists Bicuculline Brucine Colubrine Diaboline Gelsemine Hyenandrine ...
*  List of MeSH codes (D02)
... edetic acid MeSH D02.241.081.038.455 --- egtazic acid MeSH D02.241.081.038.581 --- iodoacetic acid MeSH D02.241.081.038.581.400 ... muramic acids MeSH D02.241.081.844.562 --- neuraminic acids MeSH D02.241.081.844.562.668 --- sialic acids MeSH D02.241.081.844. ... quinic acid MeSH D02.241.511.852 --- shikimic acid MeSH D02.241.511.902 --- sugar acids MeSH D02.241.511.902.107 --- ascorbic ... muramic acids MeSH D02.241.511.902.562 --- neuraminic acids MeSH D02.241.511.902.562.668 --- sialic acids MeSH D02.241.511.902. ...
*  Nanoclusters
... acrylic acid) copolymers polyelectrolyte, poly(methacrylic acid) (PMAA) etc. Gold nanoclusters have been synthesized with ... Poly(methacrylic acid)-stabilized nanoclusters have an excellent high quantum yield and can be transferred to other scaffolds ... The green-emitting gold nanoclusters can be synthesized by adding mercaptoundecanoic acid (MUA) into the prepared small gold ... The linear polyacrylates, poly(methacrylic acid), act as an excellent scaffold for the preparation of silver nanoclusters in ...
*  Demoxytocin
It has the amino acid sequence Mpa-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Mpa = β-mercaptopropionic acid), and is an analogue of ... oxytocin wherein the leading cysteine is replaced with β-mercaptopropionic acid. Carbetocin Merotocin TC OT 39 WAY-267,464 ... 389-. ISBN 978-1-60750-345-3. Tom K. A. B. Eskes; Mieczyslaw Finster (22 October 2013). Drug Therapy During Pregnancy. Elsevier ... 61-. ISBN 978-0-471-49637-3. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ...
A Serendipitous Formation of a Cysteine-bridged Disaccharide  A Serendipitous Formation of a Cysteine-bridged Disaccharide
The acetamido group on cysteine, which lowers the pKa of the carboxylic acid group of the amino acid, plays no role in the ... N-acetyl-L-cysteine bearing free carboxylic acid and sulfhydryl groups was glycosylated with 1,2,3,4,6-Penta-O-acetyl-ß-D- ... of the bridged disaccharide since 3-mercaptopropionic acid reacts in a similar manner to give the 3-mercaptopropionic acid- ...
more infohttp://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0379-43502014000100025&lng=pt&nrm=iso&tlng=en
3-Mercaptopropionic acid  3-Mercaptopropionic acid
Mercaptopropionic acid; Propanoic acid, 3-mercapto-; «beta»-Thiopropionic acid; Hydracrylic acid, 3-thio-; Mercaptopropionic ... 2-Mercaptoethanecarboxylic acid; NSC 437; «beta»-Mercaptopropanoic acid; 3-Thiolpropanoic acid ... acid; Propionic acid, 3-mercapto-; 3-Thiopropionic acid; 3MPA; 3-Thiopropanoic acid; ... Food Chem., 1997, 45, 3, 898-906, https://doi.org/10.1021/jf960456t . [all data] ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=C107960&Units=SI&Mask=2000
Studies on the adsorption of chromium(VI) onto 3-Mercaptopropionic acid coated superparamagnetic iron oxide nanoparticles  Studies on the adsorption of chromium(VI) onto 3-Mercaptopropionic acid coated superparamagnetic iron oxide nanoparticles
SPION, Chromium, 3-Mercaptopropionic acid, Adsorption National Category Materials Chemistry Identifiers. URN: urn:nbn:se:su: ... The high Cr(VI) removal, rapid adsorption kinetics and stability of adsorbent indicate that 3-MPA coated SPION could be an ... Batch adsorption experiments showed that the functionalized adsorbent recovered 45 mg of Cr(VI)/g of 3-MPA coated SPION at ... Studies on the adsorption of chromium(VI) onto 3-Mercaptopropionic acid coated superparamagnetic iron oxide nanoparticles. ...
more infohttp://su.diva-portal.org/smash/record.jsf?pid=diva2:723601
double-stranded DNA-bovine serum albumin/3-mercaptopropionic acid/CdS nanocrystal film  double-stranded DNA-bovine serum albumin/3-mercaptopropionic acid/CdS nanocrystal film
Page contains details about double-stranded DNA-bovine serum albumin/3-mercaptopropionic acid/CdS nanocrystal film . It has ... double-stranded DNA-bovine serum albumin/3-mercaptopropionic acid/CdS nanocrystal film. ...
more infohttps://nano.nature.com/nano/GR-M7424368?error=cookies_not_supported&code=43c3f458-cc7a-4727-9ffa-db25d73c6623
WUHAN SOLEADO TECHNOLOGY CO.,LTD. products list provides (R)-2-Amino-3 -mercaptopropionic Acid Food Grade Amino Acids L...  WUHAN SOLEADO TECHNOLOGY CO.,LTD. products list provides (R)-2-Amino-3 -mercaptopropionic Acid Food Grade Amino Acids L...
... mercaptopropionic Acid Food Grade Amino Acids L-Cysteine C3H7NO2S products at lowest price, view more (R)-2-Amino-3 - ... mercaptopropionic Acid Food Grade Amino Acids L-Cysteine C3H7NO2S products from WUHAN SOLEADO TECHNOLOGY CO.,LTD. of 90045569 ... mercaptopropionic Acid Food Grade Amino Acids L-Cysteine C3H7NO2S and more.. USP standard Food Grade Amino Acids L-Serine for ... L D Amino Acids Medicine grade amino acid L-glutamine Full name: L-glutamine Other names: (S)-2,5-Diamino-5-oxopentanoic acid ...
more infohttp://biz.everychina.com/aminoacidschina-r/list/
Biosensors | Free Full-Text | A Single-Use, In Vitro Biosensor for the Detection of T-Tau Protein, A Biomarker of Neuro...  Biosensors | Free Full-Text | A Single-Use, In Vitro Biosensor for the Detection of T-Tau Protein, A Biomarker of Neuro...
Self-assembled monolayers (SAM) of 3-mercaptopropionic acid (MPA) were employed to covalently immobilize the anti-T-Tau (T-Tau ... A carbodiimide conjugation approach using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and N- ... Keywords: T-Tau protein detection; differential pulse voltammetry; [Fe(CN)6]3−/4− redox probe; 3-mercaptopropionic acid (MPA) T ... Self-assembled monolayers (SAM) of 3-mercaptopropionic acid (MPA) were employed to covalently immobilize the anti-T-Tau (T-Tau ...
more infohttps://www.mdpi.com/2079-6374/7/1/10
10139-47-6 - Zinc iodide, 98% - 11661 - Alfa Aesar  10139-47-6 - Zinc iodide, 98% - 11661 - Alfa Aesar
Indicaciones de precaución: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
more infohttps://www.alfa.com/es/catalog/011661/
672-15-1 - L-Homoserine, 99% - L-2-Amino-4-hydroxybutyric acid - H-Hser-OH - L12427 - Alfa Aesar  672-15-1 - L-Homoserine, 99% - L-2-Amino-4-hydroxybutyric acid - H-Hser-OH - L12427 - Alfa Aesar
Minsang Lee; Melinda N Martin; Andre' O Hudson; Jiyeon Lee; Michael J Muhitch; Thomas Leustek. Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana. Plant Journal.2005, 41, (5), 685-696.. S Ravanel; M Droux; R Douce. Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts. Archives of Biochemistry and Biophysics.1995, 316, (1), 572-584.. ...
more infohttps://www.alfa.com/de/catalog/L12427/
Valpromide - Wikipedia  Valpromide - Wikipedia
Valpromide is no safer during pregnancy than valproic acid. Valpromide is formed through the reaction of valproic acid and ... Valpromide (marketed as Depamide by Sanofi-Aventis) is a carboxamide derivative of valproic acid used in the treatment of ... It may produce more stable plasma levels than valproic acid or sodium valproate and may be more effective at preventing febrile ... It is rapidly metabolised (80%) to valproic acid (another anticonvulsant) but has anticonvulsant properties itself. ...
more infohttps://en.wikipedia.org/wiki/Valpromide
Glutamate decarboxylase - Wikipedia  Glutamate decarboxylase - Wikipedia
Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA), and impaired function ... "Exogenous γ-aminobutyric acid treatment affects citrate and amino acid accumulation to improve fruit quality and storage ... Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to ... Wei J, Davis KM, Wu H, Wu JY (May 2004). "Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 ...
more infohttps://en.wikipedia.org/wiki/GAD_antibodies
CdS Nanoparticles with a Thermoresponsive Polymer: Synthesis and Properties  CdS Nanoparticles with a Thermoresponsive Polymer: Synthesis and Properties
A. Khan, "Preparation and characterization of N-isopropylacrylamide/acrylic acid copolymer core-shell microgel particles," ... O double-bond stretching vibration in the carboxylic acid groups bound to the CdS particles. The peaks at 1655 and 1553 cm−1 ... In the first step, 2.5 mmol of cadmium chloride monohydrate (CdCl2·H2O) was dissolved in 3 mL of deionized water. The cadmium ... Figure 3: Typical transmission electron microscopy image of CdS NPs dispersed in DMF. Scale bar represents 50 nm. Inset: SAED ...
more infohttps://www.hindawi.com/journals/jnm/2012/451506/
L-Cysteine  L-Cysteine
Propanoic Acid, 2-amino-3-mercapto-, (R)-; Thioserine; (R)-2-Amino-3-mercaptopropanoic acid; «alpha»-Amino-«beta»- ... Other names: Cysteine, L-; «beta»-Mercaptoalanine; Cystein; Cysteine; Half-cystine; L-(+)-Cysteine; L-Alanine, 3-mercapto-; NSC ... InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m1/s1 ... 2-Amino-3-mercaptopropionic acid; L-Cys *Information on this ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C3H7NO2S/c4-2
Patent US6949347 - Multiplex analysis using membrane-bound sensitizers - Google Patents  Patent US6949347 - Multiplex analysis using membrane-bound sensitizers - Google Patents
In general, these methods comprise the sequential addition of one or more amino acids, or suitably protected amino acids, to a ... The protecting group is then removed from this newly added amino acid residue and the next amino acid (suitably protected) is ... Aqueous workup converts the terminal acid chloride to a carboxylic acid. This product is analogous to 6-carboxyfluorescein, and ... cysteine amino acids, which are separated by 1-2 amino acids. The reaction involves a bi-displacement reaction to form a cyclic ...
more infohttp://www.google.com/patents/US6949347?dq=6437692
Frontiers | Designing Superoxide-Generating Quantum Dots for Selective Light-Activated Nanotherapy | Chemistry  Frontiers | Designing Superoxide-Generating Quantum Dots for Selective Light-Activated Nanotherapy | Chemistry
At the other end, a deprotonated carboxylic acid group and/or amine group provided enough electrostatic repulsion to yield ... negatively-charged mercaptopropionic ligand-coated QDs (MPA-CdTe), and zwitterionic cysteine coated QDs (Cys-CdTe), as shown in ... FIGURE 3. Figure 3. Core-shell QDs for improved stability. (A) Normalized emission spectra of QDs over time in PBS during ... Yuchen Ding2,3, Colleen M. Courtney1, Partha P. Chowdhury1,2, Annette Erbse3, Anushree Chatterjee1 and Prashant Nagpal1,2,4* ...
more infohttps://www.frontiersin.org/articles/10.3389/fchem.2018.00046/full
Vibrio cholerae ToxT Independently Activates the Divergently Transcribed aldA and tagA Genes | Journal of Bacteriology  Vibrio cholerae ToxT Independently Activates the Divergently Transcribed aldA and tagA Genes | Journal of Bacteriology
The ToxT protein is 276 amino acids in length, with the 100-amino-acid AraC/XylS family domain at its C-terminal end (17). The ... The function of the remaining 176 amino acids of ToxT, which presumably form a second domain, is unknown, and this domain has ... 3.↵. Brown, R. C., and R. K. Taylor. 1995. Organization of tcp, acf, and toxT genes within a ToxT-dependent operon. Mol. ... 2 and 3]). Based on our observations of the requirements for ToxT-directed transcription of acfA, acfD (59), tagA, tcpA (J. H. ...
more infohttps://jb.asm.org/content/187/23/7890?ijkey=65c81c3df15ee662d1752af20ad279b5bc2ff445&keytype2=tf_ipsecsha
A new adhesive technique for internal fixation in midfacial surgery - Semantic Scholar  A new adhesive technique for internal fixation in midfacial surgery - Semantic Scholar
BACKGROUND The current surgical therapy of midfacial fractures involves internal fixation in which bone fragments are fixed in their anatomical positions with osteosynthesis plates and corresponding screws until bone healing is complete. This often causes new fractures to fragile bones while drilling pilot holes or trying to insert screws. The adhesive fixation of osteosynthesis plates using PMMA bone cement could offer a viable alternative for fixing the plates without screws. In order to achieve the adhesive bonding of bone cement to cortical bone in the viscerocranium, an amphiphilic bone bonding agent was created, analogous to the dentin bonding agents currently on the market. METHODS The adhesive bonding strengths were measured using tension tests. For this, metal plates with 2.0 mm diameter screw holes were cemented with PMMA bone cement to cortical bovine bone samples from the femur diaphysis. The bone was conditioned with an amphiphilic bone bonding agent prior to cementing. The samples were
more infohttps://www.semanticscholar.org/paper/A-new-adhesive-technique-for-internal-fixation-in-Endres-Marx/4f34ff0d7c33d58144636fdbdeb61576300e0256
Using marine mammal habitat modelling to identify priority conservation zones within a marine protected area - Semantic Scholar  Using marine mammal habitat modelling to identify priority conservation zones within a marine protected area - Semantic Scholar
One common approach to marine conservation is the designation of marine protected areas (MPAs). Marine mammals have been proposed as a target species for such areas due to their role as indicators of ecosystem processes. In NE Scotland, a large multiple-use MPA has been designated to protect bottlenose dolphins Tursiops truncatus. We used broad-scale surveys throughout this MPA to model habitat preferences of different marine mammals. We aimed to investigate the degree of overlap between distributions of different species, the environmental factors influencing their distributions, and the effect of spatial scale on the significance of different environmental predictors. Bottlenose dolphins had a primarily coastal distribution with localised areas of intense use, in contrast to harbour porpoises Phocoena phocoena, harbour seals Phoca vitulina and grey seals Halichoerus grypus, which were widely dispersed throughout the MPA. At larger scales (4 × 4 km grid cells), seal distribution was significantly
more infohttps://www.semanticscholar.org/paper/Using-marine-mammal-habitat-modelling-to-identify-a-Bailey-Thompson/e17d0e5253914ab499436ff57fd620814eb63527
Desmopressin - DrugBank  Desmopressin - DrugBank
Organic acids and derivatives. Class. Carboxylic acids and derivatives. Sub Class. Amino acids, peptides, and analogues. Direct ... Alpha-amino acid amide / N-substituted-alpha-amino acid / Alpha-amino acid or derivatives / N-acylpyrrolidinePyrrolidine ... Tertiary carboxylic acid amide / Pyrrolidine / Secondary carboxylic acid amide / Primary carboxylic acid amide / Lactam / ... Tertiary carboxylic acid amides / Lactams / Organic disulfides / Primary carboxylic acid amides / Guanidines / Secondary ...
more infohttps://www.drugbank.ca/drugs/DB00035
Glutamate/GABA Synthesis and Metabolism | Sigma-Aldrich  Glutamate/GABA Synthesis and Metabolism | Sigma-Aldrich
Aminooxyacetic acid (C13408). α-Ketoglutarate (m) (K1750). │ │---------------→. ↓. Dicarboxylate carrier. Malate (02300). ... Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Acetylenic GABA (A230). GABA (A2129). │ │---------------→. │ ... Aminooxyacetic acid (C13408). 3-Mercaptopropionic acid (M5801). γ-Vinyl GABA (V8261). GABAculine (A3539). ... However, in the case of the carbonyl-trapping agent aminooxyacetic acid its Ki value for inhibition of GABA-transaminase is 10- ...
more infohttps://www.sigmaaldrich.com/technical-documents/articles/biology/rbi-handbook/non-peptide-receptors-synthesis-and-metabolism/glutamate-gaba-synthesis-and-metabolism.html
citrate/3-sulfanylpropanoic acid-stabilized gold nanoparticles  citrate/3-sulfanylpropanoic acid-stabilized gold nanoparticles
Page contains details about citrate/3-sulfanylpropanoic acid-stabilized gold nanoparticles . It has composition images, ... mercaptopropionic acid 3-MPA MPA See all names (4) Type Single Compound ...
more infohttps://nano.nature.com/nano/GR-M5207950?error=cookies_not_supported&code=da000ce9-433f-4aaa-a615-c827d78e8dc8
  • Nutraceutical Ingredients Gamma Aminobutyric Acid ( GABA ) C4H9NO2 Name: Gamma Aminobutyric Acid (GABA) Cas:56-12-2 English Name: gamma aminobutyric acid Structure: NH2CH2CH2CH2COO. (everychina.com)
  • Glutamate decarboxylase or glutamic acid decarboxylase ( GAD ) is an enzyme that catalyzes the decarboxylation of glutamate to GABA and CO 2 . (wikipedia.org)
  • [3] Together, these two enzymes maintain the only physiological supply of GABA in mammals. (wikipedia.org)
  • Another problem with amino-oxyacetic acid is that it potently inhibits both glutamate decarboxylase and GABA-transaminase (see Table below). (sigmaaldrich.com)
  • It appears that glutamate formed from glutamine may be metabolized in the tricarboxylic acid (TCA) cycle prior to its conversion to GABA, which may allow new alternative regulatory mechanisms. (sigmaaldrich.com)
  • However, in the case of the carbonyl-trapping agent aminooxyacetic acid its Ki value for inhibition of GABA-transaminase is 10-fold lower than that for glutamate decarboxylase. (sigmaaldrich.com)
  • For the two relevant monofunctional compound classes, carboxylic acids/esters and mercaptans, literature data were compiled, and by comparison with structurally similar compounds without these functional groups, the influence of COOH/COOR' and SH groups on biodegradability was evaluated. (deepdyve.com)
  • However, there is also some use in consumer products, [email protected] e.g. several thousand tons per year of thioglycolic acid and its 1 salts go into cosmetic and cleaning formulations and are there- Institute of Sustainable and Environmental Chemistry, Leuphana fore released to the environment directly or indirectly via sew- University Lüneburg, Universitätsallee 1, 21335 Lüneburg, Germany 2 age treatment plants. (deepdyve.com)
  • Thereby, an existing rule of thumb for biodegradation of carboxylic acids/esters was supported by experimental data, and a rule of thumb could be formulated for mercaptans. (deepdyve.com)
  • USP standard Food Grade Amino Acids L-Serine for sports drinks and diet drinks Abbreviation: L-Ser CAS Number: 56-45-1 Conforms To: USP, EP Chemical Name: (S)-2-Amino-3 -hydroxypro. (everychina.com)
  • Pharmaceutical raw material Food Grade Amino Acids L-Histidine for biochemical reagents Abbreviation: L-His CAS Number: 71-00-1 Conforms To: USP, EP Chemical Name: (S)-2-Amino -1H. (everychina.com)
  • chemicals regulations, e.g. the European Union REACH Mercaptocarboxylic acids and their esters are a chemical Regulation (EU 2006). (deepdyve.com)
  • For reducing the scale of the 1×3 MMI coupler in SOI, several kinds novel structure couplers are analyzed. (spie.org)
  • Because toxT is also located within the large tcpA operon ( 3 , 16 ), once ToxT protein has been produced it is able to activate its own expression through a positive-feedback loop ( 61 ). (asm.org)