Cardiac sympathetic activity estimated by 123I-MIBG myocardial imaging in patients with dilated cardiomyopathy after beta-blocker or angiotensin-converting enzyme inhibitor therapy. (1/545)

Impaired cardiac sympathetic activity can be evaluated by 123I-metaiodobenzylguanidine (MIBG) imaging. METHODS: We studied the significance of MIBG imaging for 24 patients (age 58+/-12 y) with dilated cardiomyopathy (DCM). We compared 12 patients (group A) treated with metoprolol (dose from 30-60 mg/d) with 12 patients treated with angiotensin-converting enzyme (ACE) inhibitors. Patients were studied before treatment, after 5 mo of treatment (only in group A) and after 1 y of treatment. Cardiac MIBG uptake was assessed as the heart-to-mediastinum activity ratio (H/M) and total defect score (TDS) from anterior planar and SPECT MIBG images, which were acquired in 4 h after tracer injection. New York Heart Association (NYHA) class and left ventricular ejection fraction (LVEF) calculated by echocardiography were also assessed. RESULTS: TDS decreased in both groups (in group A, from 30+/-7 through 23+/-9 to 18+/-10; P < 0.01, in group B, from 30+/-6 to 24+/-8; P < 0.01) and H/M was increased in both groups (in group A, from 1.87+/-0.31 through 2.03+/-0.28 to 2.14+/-0.29; P < 0.01, in group B, from 1.82+/-0.28 to 1.94+/-0.26; P < 0.05). But TDS and H/M were more improved in group A than in group B (P < 0.05). LVEF was significantly increased in only group A (from 38+/-6 through 43+/-8 to 49%+/-9%; P < 0.01). NYHA improved in both groups (in group A, from mean 2.5 through 2.1 to 1.8; P < 0.01, in group B, from mean 2.6 to 2.1; P < 0.05) but was more improved in group A than in group B (P < 0.05). CONCLUSION: Cardiac function, symptom and cardiac sympathetic activity evaluated by MIBG images improved after the beta-blocker therapy more than with the treatment that used ACE inhibitors.  (+info)

Sympathetic nerve alterations assessed with 123I-MIBG in the failing human heart. (2/545)

Norepinephrine (NE) reuptake function is impaired in heart failure and this may participate in myocyte hyperstimulation by the neurotransmitter. This alteration can be assessed by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. METHODS: To determine whether the impairment of neuronal NE reuptake was reversible after metoprolol therapy, we studied 18 patients (43+/-7 y) with idiopathic dilated cardiomyopathy who were stabilized at least for 3 mo with captopril and diuretics. Patients underwent, before and after 6 mo of therapy with metoprolol, measurements of radionuclide left ventricular ejection fraction (LVEF), maximal oxygen consumption and plasma NE concentration. The cardiac adrenergic innervation function was scintigraphically assessed with MIBG uptake and release measurements on the planar images obtained 20 min and 4 h after tracer injection. To evaluate whether metoprolol had a direct interaction with cardiac MIBG uptake and release, six normal subjects were studied before and after a 1-mo metoprolol intake. RESULTS: In controls, neither cardiac MIBG uptake and release nor circulating NE concentration changed after the 1-mo metoprolol intake. Conversely, after a 6-mo therapy with metoprolol, patients showed increased cardiac MIBG uptake (129%+/-10% versus 138%+/-17%; P = 0.009), unchanged cardiac MIBG release and decreased plasma NE concentration (0.930+/-412 versus 0.721+/-0.370 ng/mL; P = 0.02). In parallel, patients showed improved New York Heart Association class (2.44+/-0.51 versus 2.05+/-0.23; P = 0.004) and increased LVEF (20%+/-8% versus 27%+/-8%; P = 0.0005), whereas maximal oxygen uptake remained unchanged. CONCLUSION: Thus, a parallel improvement of myocardial NE reuptake and of hemodynamics was observed after a 6-mo metoprolol therapy, suggesting that such agents may be beneficial in heart failure by directly protecting the myocardium against excessive NE stimulation.  (+info)

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG). (3/545)

Tumour-selective acidification is of potential interest for enhanced therapeutic gain of pH sensitive drugs. In this study, we investigated the feasibility of a tumour-selective reduction of the extracellular and intracellular pH and their effect on the tumour response of selected anti-cancer drugs. In an in vitro L1210 leukaemic cell model, we confirmed enhanced cytotoxicity of chlorambucil at low extracellular pH conditions. In contrast, the alkylating drugs melphalan and cisplatin, and bioreductive agents mitomycin C and its derivative EO9, required low intracellular pH conditions for enhanced activation. Furthermore, a strong and pH-independent synergism was observed between the pH-equilibrating drug nigericin and melphalan, of which the mechanism is unclear. In radiation-induced fibrosarcoma (RIF-1) tumour-bearing mice, the extracellular pH was reduced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) or its analogue benzylguanidine (BG) plus glucose. To simultaneously reduce the intracellular pH, MIBG plus glucose were combined with the ionophore nigericin or the Na+/H+ exchanger inhibitor amiloride and the Na+-dependent HCO3-/Cl- exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid (DIDS). Biochemical studies confirmed an effective reduction of the extracellular pH to approximately 6.2, and anti-tumour responses to the interventions indicated a simultaneous reduction of the intracellular pH below 6.6 for at least 3 h. Combined reduction of extra- and intracellular tumour pH with melphalan increased the tumour regrowth time to 200% of the pretreatment volume from 5.7 +/- 0.6 days for melphalan alone to 8.1 +/- 0.7 days with pH manipulation (P < 0.05). Mitomycin C related tumour growth delay was enhanced by the combined interventions from 3.8 +/- 0.5 to 5.2 +/- 0.5 days (P < 0.05), but only in tumours of relatively large sizes. The interventions were non-toxic alone or in combination with the anti-cancer drugs and did not affect melphalan biodistribution. In conclusion, we have developed non-toxic interventions for sustained and selective reduction of extra- and intracellular tumour pH which potentiated the tumour responses to selected anti-cancer drugs.  (+info)

Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG). (4/545)

meta-iodobenzylguanidine (MIBG) radiolabelled with iodine-131 is used for diagnosis and treatment of neuroadrenergic neoplasms such as phaeochromocytoma and neuroblastoma. In addition, non-radiolabelled MIBG, administered i.v., is used in several clinical studies. These include palliation of the carcinoid syndrome, in which MIBG proved to be effective in 60% of the patients. Oral MIBG administration might be convenient to maintain palliation and possibly improve the percentage of responders. We have, therefore, investigated the feasibility of oral administration of MIBG in an animal model. Orally administered MIBG demonstrated a bioavailability of 59%, with a maximal tolerated dose of 60 mg kg(-1). The first and only toxicity encountered was a decrease in renal function, measured by a reduced clearance of [51Cr]EDTA and accompanied by histological tubular damage. Repeated MIBG administration of 40 mg kg(-1) for 5 sequential days or of 20 mg kg(-1) for two courses of 5 sequential days with a 2-day interval did not affect renal clearance and was not accompanied by histological abnormalities in kidney, stomach, intestines, liver, heart, lungs, thymus, salivary glands and testes. Because of a sufficient bioavailability in absence of gastrointestinal toxicity, MIBG is considered suitable for further clinical investigation of repeated oral administration in patients.  (+info)

Cardiac metaiodobenzylguanidine uptake in patients with moderate chronic heart failure: relationship with peak oxygen uptake and prognosis. (5/545)

OBJECTIVES: This prospective study was undertaken to correlate early and late metaiodobenzylguanidine (MIBG) cardiac uptake with cardiac hemodynamics and exercise capacity in patients with heart failure and to compare their prognostic values with that of peak oxygen uptake (VO2). BACKGROUND: The cardiac fixation of MIBG reflects presynaptic uptake and is reduced in heart failure. Whether it is related to exercise capacity and has better prognostic value than peak VO2 is unknown. METHODS: Ninety-three patients with heart failure (ejection fraction <45%) were studied with planar MIBG imaging, cardiopulmonary exercise tests and hemodynamics (n = 44). Early (20 min) and late (4 h) MIBG acquisition, as well as their ratio (washout, WO) were determined. Prognostic value was assessed by survival curves (Kaplan-Meier method) and uni- and multivariate Cox analyses. RESULTS: Late cardiac MIBG uptake was reduced (131+/-20%, normal values 192+/-42%) and correlated with ejection fraction (r = 0.49), cardiac index (r = 0.40) and pulmonary wedge pressure (r = -0.35). There was a significant correlation between peak VO2 and MIBG uptake (r = 0.41, p < 0.0001). With a mean follow-up of 10+/-8 months, both late MIBG uptake (p = 0.04) and peak VO2 (p < 0.0001) were predictive of death or heart transplantation, but only peak VO2 emerged by multivariate analysis. Neither early MIBG uptake nor WO yielded significant insights beyond those provided by late MIBG uptake. CONCLUSIONS: Metaiodobenzylguanidine uptake has prognostic value in patients with wide ranges of heart failure, but peak VO2 remains the most powerful prognostic index.  (+info)

Loss of 123I-MIBG uptake by the heart in Parkinson's disease: assessment of cardiac sympathetic denervation and diagnostic value. (6/545)

Myocardial imaging with 123I-metaiodobenzylguanidine (MIBG) was performed on 35 patients with Parkinson's disease and 24 control subjects to evaluate cardiac sympathetic function in patients with Parkinson's disease, verify this phenomenon and examine whether myocardial MIBG uptake and clearance are correlated with the clinical severity of Parkinson's disease. METHODS: We studied 35 patients with Parkinson's disease and 24 control subjects with other central nervous system diseases. The latter group consisted of 12 subjects with other neurodegenerative disorders (4 with spinocerebellar degeneration, 2 with amyotrophic lateral sclerosis, 3 with progressive supranuclear palsy and 3 with corticobasal degeneration and 12 patients with cerebral infarction (CI), 6 with vascular parkinsonism and 6 without it. Early and delayed images of the anterior view were obtained 15 min and 4 h after injection of 123I-MIBG, respectively. MIBG uptake was quantified by calculating a heart-to-mediastinum count (H/M) ratio. RESULTS: The H/M ratio was markedly reduced in the patients with Parkinson's disease (II to V on the Hoehn and Yahr scale) compared with the control subjects. None of the subjects with neurodegenerative diseases showed a marked decrease in myocardial MIBG uptake nor did any subject with CI. CONCLUSION: Our findings indicate that, in Parkinson's disease, a reduction in myocardial MIBG uptake is a very common, specific phenomenon that can be used to detect cardiac autonomic dysfunction to diagnose Parkinson's disease, particularly in patients without typical signs and symptoms.  (+info)

Myocardial stunning caused by sympathetic nerve injury after an operation on cervical vertebrae. (7/545)

In this case, electrocardiographic inverted T waves appeared after cervical laminaplasty and echocardiogram showed temporary wall motion abnormality. Myocardial metaiodobenzylguanidine (MIBG) uptake was obviously reduced in the same area where the wall motion abnormalities appeared in the echocardiogram, although no abnormalities were detected with myocardial thallium scintigraphy and coronary angiography. The myocardial stunning was caused by injury to the sympathetic nerves from a surgical procedure on the cervical vertebrae.  (+info)

(123)I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease. (8/545)

OBJECTIVES: (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy is clinically used to estimate local myocardial sympathetic nerve damage in some forms of heart disease, autonomic nerve disturbance in diabetic neuropathy, and disturbance of the autonomic nervous system in neurodegenerative disease. In the present study, examinations were performed to clarify (1) the proportion of cardiac sympathetic nerve disturbance in Parkinson's disease, (2) the usefulness of (123)I-MIBG myocardial scintigraphy to detect sympathetic nerve disturbances compared with autonomic function tests, (3) cardiac function in patients who have a decreased MIBG uptake in (123)I-MIBG myocardial scintigraphy, (4) the usefulness of (123)I-MIBG myocardial scintigraphy to differentiate Parkinson's disease from the other neurological diseases mimicking it. METHODS: (123)I-MIBG myocardial scintigraphy was performed, together with autonomic function tests and cardiac examinations in 46 patients with Parkinson's disease and 25 patients with vascular parkinsonism, essential tremor, or multiple system atrophy. RESULTS: In an anterior image study, the average count per pixel in heart to mediastinum (H/M) ratio decreased in 80% of the patients with Parkinson's disease in the early phase and 84% in the late phase. The mean H/M ratio in Parkinson's disease was significantly lower than that in controls and the other diseases. The H/M ratio tended to decrease with the disease progression. In almost half of the patients in Hoehn and Yahr stage I, the H/M ratio was already decreased. The sympathetic skin response in upper and lower limbs, head up tilt test, and coefficient of variation of R-R interval were abnormal in 17%, 31%, 30%, and 17% of the patients, respectively. All the patients with abnormal autonomic functions were in Hoehn and Yahr stage III, IV, or V. Echocardiography showed normal left ventricular function. Twenty four hour Holter electrocardiography detected no serious arrhythmias except for one patient with non-sustained ventricular tachycardia. CONCLUSION: (123)I-MIBG myocardial scintigraphy might detect early disturbances of the sympathetic nervous system in Parkinson's disease and might give useful diagnostic information to differentiate vascular parkinsonism, essential tremor, and multiple system atrophy from Parkinson's disease.  (+info)

In 123I-metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy, the early heart-to-mediastinum (H/M) ratio is considered to reflect the density of the cardiac sympathetic nerve endings, washout rate (WR) is an indicator of the cardiac sympathetic tone, and the delayed H/M ratio reflects both. The Delayed H/M ratio is usually used to support the diagnosis of Lewy body diseases (LBDs) and idiopathic REM sleep behavior disorder (iRBD); however, which values should be used have not been specified. Here, we hypothesized that the combination of these values is appropriate for the diagnostic purpose.In this single-center retrospective cohort study, we recruited 106 patients with LBDs or iRBD and 33 patients without those diseases, of whom we reviewed the 123I-MIBG myocardial scintigraphy results.Sensitivity/specificity to diagnose LBDs and iRBD were 0.77/0.94 for the early H/M ratio (≤ 2.0), 0.82/0.94 for the delayed H/M ratio (≤ 2.0), and 0.89/0.91 for WR (≥ 23.0). When patients were ...
Background: Iodine-123-metaiodobenzylguanidine (123I-MIBG) has been used to assess function of the cardiac sympathetic nervous system in patients with chronic heart failure. Recently, we and others demonstrated that cardiac 123I-MIBG imaging represented a prognostic marker in not only systolic heart failure (SHF) patients and but also diastolic heart failure (DHF) patients. From sub-analysis of ADMIRE-HF trial, the group of SHF patients with diabetes mellitus (DM) who presented low heart to mediastinum (H/M) ratio showed poor prognosis in other groups. Epidemiologic and experimental study demonstrated that hyperglycemia facilitated myocardial diastolic dysfunction. Therefore, we examined the influence of DM on prognostic utility of cardiac 123I-MIBG imaging in DHF patients.. Methods and Results: We performed 123I-MIBG scintigraphy and echocardiography in consecutive 128 heart failure patients with left ventricular ejection fraction ≥ 50% (71 men, mean age 64±15 years) who admitted to our ...
In the present study, we found complete defects on MIBG myocardial scans in 8 of 12 patients and limited uptake in the remaining 4 in association with severe systemic autonomic dysfunction. The incidence and magnitude of myocardial accumulation of MIBG were independent of clinical findings, including neurologic disabilities, duration of the illness, extent of endomyocardial amyloid deposition, ECG QRS voltage and ventricular wall thickness. These findings strongly suggest that cardiac adrenergic denervation due to autonomic nervous degeneration ([28]) accounts for alterations in I-123 MIBG myocardial imaging in patients with familial amyloid polyneuropathy. The presence of small localized concentrations of MIBG in the LV anterior wall in some patients indicates that myocardial sympathetic innervation is not equally impaired in this disease.. As we have previously reported ([34]), Tc-99m PYP scintigraphy may have the potential to detect early myocardial amyloid infiltration in patients with ...
In heart failure secondary to chronic mechanical overload, cardiac sympathetic neurons demonstrate depressed catecholamine synthetic and transport function. To assess the potential of sympathetic neuronal imaging for detection of depressed transport function, serial scintigrams were acquired after the intravenous administration of metaiodobenzylguanidine [131I] to 13 normal dogs, 3 autotransplanted (denervated) dogs, 5 dogs with left ventricular failure, and 5 dogs with compensated left ventricular hypertrophy due to a surgical arteriovenous shunt. Nine dogs were killed at 14 hours postinjection for determination of metaiodobenzylguanidine [131I] and endogenous norepinephrine content in left atrium, left ventricle, liver, and spleen. By 4 hours postinjection, autotransplanted dogs had a 39% reduction in mean left ventricular tracer accumulation, reflecting an absent intraneuronal tracer pool. Failure dogs demonstrated an accelerated early mean left ventricular tracer efflux rate (26.0%/hour ...
Metaiodobenzylguanidine (MIBG) is a substance that is taken up by neuroblastoma or pheochromocytoma/paraganglioma tumor cells. MIBG is combined with radioactive iodine (131 I) in the laboratory to form a radioactive compound 131 I-MIBG. This radioactive compound delivers radiation specifically to the cancer cells and causes them to die.. The purpose of this research protocol is to provides a mechanism to deliver MIBG therapy when clinically indicated, but also to provide a mechanism to continue to collect efficacy and toxicity data that will be provided. ...
In connection with clinical 131I-MIBG studies of patients with suspected pheochromocytoma and adrenomedullary hyperplasia quantitative biokinetic data have been collected in order to improve the present estimations of absorbed dose to various organs and tissues. Whole-body profiles as a function of time were measured with a whole-body counter. The retention in the total body and in the thyroid gland could be derived from the measured whole-body profiles by summing up the corresponding values. The retention of 131I-MIBG could not be exactly measured for further organs from the whole-body profiles in man. For this reason animal studies were performed with mice. The biokinetic animal data were transferred to man in form of the cumulative activity for the various organs. The mean absorbed dose for selected organs per injected activity unit was calculated using the concept of absorbed fractions (MIRD method) taking into account the radioactivity within the remaining body. Except for both the adrenal medulla
Purpose: 131I-metaiodobenzylguanidine (MIBG) is a targeted radiopharmaceutical with activity in patients with relapsed or refractory neuroblastoma. Irinotecan is a known radiosensitizer with activity in neuroblastoma. This phase I study aimed to determine the recommended phase 2 dose of MIBG together with fixed doses of vincristine and irinotecan.. Experimental Design: Patients 1 to 30 years old with relapsed or refractory neuroblastoma and MIBG-avid tumors were eligible. All patients had autologous hematopoietic stem cells (PBSC) available and met standard phase I organ function requirements. Irinotecan (20 mg/m2/dose IV) was given on days 0 to 4 and 7 to 11, with vincristine (1.5 mg/m2 IV) on days 0 and 7. MIBG was given on day 1 following a 3 + 3 phase I dose escalation design starting at 8 mCi/kg MIBG. PBSCs were administered at dose level 8 mCi/kg for prolonged myelosuppression and for all patients at 12 mCi/kg or more.. Results: Twenty-four patients evaluable for dose escalation (median ...
The purpose of this study is to evaluate the efficacy and toxicity of tandem HDCT/ASCT including high-dose 131I-metaiodobenzylguanidine (MIBG) treatment. In
M. Esler; Assessment of Sympathetic Nervous Function in Humans from Noradrenaline Plasma Kinetics. Clin Sci (Lond) 1 March 1982; 62 (3): 247-254. doi: https://doi.org/10.1042/cs0620247. Download citation file:. ...
131I-Metaiodobenzylguanidine (MIBG) is a guanethi-dine derivative that is structurally similar to norepi-nephrine, and therefore concentrates in the
Our findings demonstrate striking similarities in the magnitude of sympathetically mediated coronary vasodilation between the subjects with type 1 and type 2 diabetes. The results of multivariable analysis assigned an important role to the degree of cardiac sympathetic dysfunction and the duration of diabetes in predicting the MBF response to the CPT, consistent with previous results from our laboratory (6). Importantly, plasma glucose was a statistically significant predictor of the flow response to the CPT that provided incremental information above and beyond that provided by the HED retention data and the duration of diabetes. Furthermore, the presence of type 1 (insulin deficiency) or type 2 (insulin resistance) diabetes had no significant effect on the MBF response to cold, even among those without cardiac sympathetic dysfunction. Together, these findings agree and extend previous studies in healthy volunteers (10)and in subjects with impaired glucose tolerance (11). Williams et al. ...
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Whole-body 123I-Metaiodobenzylguanidine (mIBG) scintigraphy is used as primary image modality to visualize neuroblastoma tumours and metastases because it is the most sensitive and specific radioactive tracer in staging the disease and evaluating the response to treatment. However, especially in paediatric neuroblastoma, information from mIBG scans is difficult to extract because of acquisition difficulties that produce low definition images, with poor contours, resolution and contrast. These problems limit physician assessment. Current oncological guidelines are based on qualitative observer-dependant analysis. This makes comparing results taken at different moments of therapy, or in different institutions, difficult. In this paper, we present a computerized method that processes an image and calculates a quantitative measurement considered as its entropy, suitable for the identification of abnormal uptake regions, for which there is enough suspicion that they may be a tumour or metastatic site. This
Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal. Perrone-Filardi, Pasquale; Paolillo, Stefania; Dellegrottaglie, Santo; Gargiulo, Paola; Savarese, Gianluigi; Marciano, Caterina; Casaretti, Laura; Cecere, Milena; Musella, Francesca; Pirozzi, Elisabetta; Parente, Antonio; Cuocolo, Alberto // Heart;Nov2011, Vol. 97 Issue 22, p1828 Cardiac sympathetic activity can be assessed by 123I-labelled meta-iodobenzylguanidine (MIBG) scintigraphy. Abnormalities of sympathetic cardiac activity have been shown in patients with heart failure, resulting in reduced MIBG uptake. Abnormal MIBG uptake predicts cardiac death, arrhythmias and... ...
According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) is impaired in many lung diseases and low lung uptake of 123I-MIBG suggests endothelial dysfunction of the pulmonary artery. 123I-MIBG scintigraphy in patients with pulmonary hypertension (PH) has not yet been clinically evaluated. We hypothesized that the lung uptake of 123I-MIBG is reduced in patients with PH and differs among PH subtypes. The purpose of the present study was to analyze the lung uptake of 123I-MIBG in patients with PH and compare it with the data obtained by echocardiography or right heart catheterization ...
Some patients are at risk for life-threatening fast heart rates. These can frequently be treated by using a catheter inside the heart to burn away the cells
... Information for Physicians. AnazaoHealth, Nuclear Medicine Division, understands that your patients treatment needs are very specific. We will compound to your precise prescription, allowing you the flexibility of providing either I-131 MIBG or I-123 MIBG in your specified dose (mCi).. AnazaoHealth can provide I-131 MIBG five days a week. I-123 MIBG is available Tuesday through Thursday.. Please contact AnazaoHealth for information about these products.. ...
The aim of this review is to describe the role of nuclear imaging modalities using different radiotracers such as labeled nor-cholesterol, metaiodobenzylguanidine (MIBG) and deoxy-glucose (FDG) in the diagnostic evaluation of patients with adrenal tumours to perform lesion characterization in comparison with MR imaging.
Image of neuroblastoma using the radiopharmaceutical metaiodobenzylguanidine. The arrows identify areas of drug uptake to identify metasta
Well this is awkward... I think its been 12.. days, I dont even know quite honestly, Im completely disconnected from the world right now. I kind of left all of you hanging, I apologize for my absence. I was just having MIBG radiotherapy, no big deal, my tumours havent been very happy with me that I…
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Background: Left cardiac sympathetic denervation (LCSD) suppresses ventricular arrhythmias (VAs), and reduces the incidence of sudden cardiac death (SCD). The role of bilateral cardiac sympathetic denervation (BCSD) remains unknown. The purpose of this study was to report the effects of BCSD in a small patient cohort.. Methods: We reviewed records of 6 patients (5 males, age 47-75 years, 66.7% non-ischemic cardiomyopathy) who underwent BCSD to treat severe VAs refractory to all other treatment modalities. Reversible causes of VAs were addressed in all patients. All patients were on beta-blocker therapy, and at least one antiarrhythmic drug. Five patients underwent catheter mapping with endocardial and/or epicardial ablation to control VAs (mean 2.2±0.5 ablations/patient). VAs persisted in 3 patients despite prior LCSD. Surgical BCSD was successfully performed in all patients (50% simultaneously, 50% right cardiac sympathetic denervation after prior unsuccessful LCSD).. Results: After BCSD, mean ...
TY - JOUR. T1 - Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma. T2 - A European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study. AU - Di Giannatale, Angela. AU - Dias-Gastellier, Nathalie. AU - Devos, Annick. AU - Mc Hugh, Kieran. AU - Boubaker, Ariane. AU - Courbon, Frederic. AU - Verschuur, Arnaud. AU - Ducassoul, Stéphane. AU - Malekzadeh, Katty. AU - Casanova, Michela. AU - Amoroso, Loredana. AU - Chastagner, Pascal. AU - Zwaan, Christian M.. AU - Munzer, Caroline. AU - Aerts, Isabelle. AU - Landman-Parker, Judith. AU - Riccardi, Riccardo. AU - Le Deley, Marie Cecile. AU - Geoerger, Birgit. AU - Rubie, Hervé. PY - 2014/1. Y1 - 2014/1. N2 - Purpose To assess objective response rate (ORR) after two cycles of temozolomide in combination with topotecan (TOTEM) in children with refractory or relapsed neuroblastoma. Patients and Methods This multicenter, non-randomised, phase II study included children ...
The Specific Aim #1 of this study is to assess, with 123iodine metaiodobenzylguanidine (123I-MIBG imaging), whether cardiac resynchronization therapy (CRT) rebalances and improves the integrity and function of sympathetic nerve terminals in the failing myocardium. The study will test the hypothesis that resynchronization of biventricular contractility attenuates excessive sympathetic drive, and improves autonomic function and cardiac performance.. The Specific Aim #2 of this study is to determine the relationship between 123I-MIBG labeling of sympathetic activity and physiological measures of cardiopulmonary and autonomic function. This aim is to test the hypothesis that impaired cardiac sympathetic activity, determined by 123I-MIBG imaging will be associated with poorer submaximal exercise gas exchange (higher ventilation - carbon dioxide (CO2) slopes, low end tidal CO2, reduced oxygen pulse and a more rapid frequency response) as well as reduced heart rate power spectral frequencies, a blunted ...
TY - JOUR. T1 - Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats. AU - Tsuchimochi, Hirotsugu. AU - Hayes, Shawn G.. AU - McCord, Jennifer L.. AU - Kaufman, Marc P. PY - 2009/4. Y1 - 2009/4. N2 - Both static and dynamic exercise are known to increase cardiac pump function as well as arterial blood pressure. Feedforward control by central command and feedback control by the exercise pressor reflex are thought to be the neural mechanisms causing these effects during exercise. It remains unknown as to how each mechanism activates cardiac sympathetic nerve activity (CSNA) during exercise, especially at its onset. Thus we examined the response of CSNA to stimulation of the mesencephalic locomotor region (MLR, i.e., central command) and to static muscle contraction of the triceps surae muscles or stretch of the calcaneal tendon in decerebrate cats. We found that MLR stimulation immediately increased CSNA, which was followed by a gradual ...
Parkinsons disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism-predominant multiple system atrophy (MSA-p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA-p
Study Type: Pilot/interventional. Study Title: 124I-Metaiodobenzylguanidine (MIBG) PET/CT Diagnostic Imaging and Dosimetry for Patients With Neuroblastoma: A Pilot Study. Study Sponsor and Collaborators: University of California, San Francisco. Purpose: To describe organ dosimetry and acute toxicities using no carrier added and carrier added 124I-MIBG PET/CT in patients with relapsed or refractory neuroblastoma who are currently enrolled on a treatment protocol with 131I-MIBG. Eligible Ages: 3 years or older. Eligible Genders: Both. Accepts Healthy Volunteers: No. Primary Outcome Measures: • Measurements of organ dosimetry using high specific activity (no carrier added) 124I-MIBG PET/CT (time frame: PET/CT scans on days 0-week 7). • Measurements of organ dosimetry using low specific activity (carrier added) 124I-MIBG PET/CT (time frame: PET/CT scans on days 0-week 7). • Change from baseline of blood pressure measurements at week 7 (time frame: safety assessments on days 0- week 7). • ...
A Guanidine analog with specific affinity for Tissues of the Sympathetic Nervous System and related Tumors. The radiolabeled Forms are used as Antineoplastic Agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a Neuron-blocking agent which has a strong affinity for, and Retention in, the Adrenal Medulla and also inhibits ADP-Ribosyltransferase ...
18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of 18F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. 131I-meta-iodobenzylguanidine (131I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced 18F-LMI1195 washout from PC12 cells, while tracer retention remained stable in the SK-N-SH cells. After
Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...
Background: \(^{18}\)F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (\(^{18}\)F-LMI1195) is a new class of PET tracer designed for sympathetic nervous imaging of the heart. The favorable image quality with high and specific neural uptake has been previously demonstrated in animals and humans, but intracellular behavior is not yet fully understood. The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover. Results: Both vesicle-rich (PC12) and vesicle-poor (SK-N-SH) norepinephrine-expressing cell lines were used for in vitro tracer uptake studies. After 2 h of \(^{18}\)F-LMI1195 preloading into both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. \(^{131}\)I-meta-iodobenzylguanidine (\(^{131}\)I-MIBG) served as a reference. Both high concentration KCl and reserpine enhanced \(^{18}\)F-LMI1195 washout from PC12 ...
Neuroblastoma is a highly malignant tumor of children that arises in the peripheral sympathetic nervous system, and spreads widely to bones and bone marrow. The survival of children with metastatic neuroblastoma is less than 40%, despite intensive chemotherapy, radiation and bone marrow transplant. Metaiodobenzylguanidine (MIBG) is a chemical similar in structure to noradrenaline and specifically taken up by neuroblastoma, thus providing a means to detect tumor metastases and to deliver intravenous tumor-targeted radiation by attaching a radioactive iodine molecule. 131I-MIBG has achieved responses of 40% in children with relapsed neuroblastoma, with very few side effects, but due to the special requirements of administering radioactive medicines, is used at only a few centers and is not yet approved for commercial use by the FDA. Furthermore, there is very little pre-clinical data on using MIBG in combination with the new molecularly targeted drugs to provide a platform for overcoming resistant ...
Sudomotor dysfunction testing may indicate to physicians of a patients peripheral nerve and cardiac sympathetic dysfunction. To learn more Contact Us.
I met with Lisas doctor last Thursday before her last dose of chemo of round four. We talked about what to expect during and after her MIBG Therapy scheduled for April 26. The 26th will mostly be prepping her for the Therapy that will begin on the 27th. On the 27th shell begin her treatment which will isolate her for at least 36 hours because she will be so radioactive. During those 36 hours only the medical personnel are able to enter the room in full hazmat gear to take vitals and give meds and chemo. Yes, on top of the MIBG Therapy Lisa will be receiving her 5th round of chemo. After 36 hours the level of radiation emanating from Lisa should be low enough for Linda and I to go in for short visits. After another 36 hours levels should be low enough for her to discharged. Once home with her we can expect to experience all the "normal" side effects of chemo and radiation treatment. Were cautioned that while we can resume our usual lifestyle, we should not sit for prolonged periods with Lisa ...
Àhámọ́ jẹ́ ẹyọ aládìmú àti oníàmúṣe fún gbogbo àwọn ohun ẹlẹ́ẹ̀mì tí a mọ̀. Òhun ni ẹyọ ẹ̀mí tó kéréjùlọ tó jẹ́ tòsọ́tọ̀ bí i ohun alàyè, wọ́n sì tún ùnpé bíi òkúta ìkọ́ ẹ̀mí.[1] Àwọn ohun ẹlẹ́ẹ̀mí ṣe é tòsọ́tọ̀ bíi oníàhámọ́kan (consisting of a single cell; èyí kàkún ọ̀pọ̀ àwọn baktéríà) tàbí oníàhámọ́púpọ̀ (èyí kàkún àwọn ọ̀gbìn àti ẹranko). Ara àwọn ọmọ ènìyàn ní bíi ẹgbẹgbẹ̀rúnkẹta 100 àhámọ́; ìtóbi àhámọ́ jẹ́ 10 µm nígbàtí ìkórajọ àhámọ́ jẹ́ 1 nanogram. ...
This is the only in-depth, single author survey of heart development. It will provide a more systematic, up-to-date synthesis of the subject than any other volume, spanning the range from classical anatomical studies to recent findings in molecular biology. It also covers topics that are often omitted from discussions of heart development, such as myocardial function, cardiac innervation, and conduction development and clinical correlates will be discussed throughout.
This is the only in-depth, single author survey of heart development. It will provide a more systematic, up-to-date synthesis of the subject than any other volume, spanning the range from classical anatomical studies to recent findings in molecular biology. It also covers topics that are often omitted from discussions of heart development, such as myocardial function, cardiac innervation, and conduction development and clinical correlates will be discussed throughout.
H&Ms business concept is to offer fashion and quality at the best price in a sustainable way. H&M has since it was founded in 1947 grown into one of the worlds leading fashion companies. The content of this site is copyright-protected and is the property of H&M Hennes & Mauritz AB. ...
H&Ms business concept is to offer fashion and quality at the best price in a sustainable way. H&M has since it was founded in 1947 grown into one of the worlds leading fashion companies. The content of this site is copyright-protected and is the property of H&M Hennes & Mauritz AB. ...
Journal: EJNMMI - European Journal of Nuclear Medicine and Molecular Imaging ArticleTitle: Cardiac sympathetic neuronal damage precedes myocardial fibrosis in patients with Anderson-Fabry disease
Multiple system atrophy (MSA) is characterised by parkinsonism, cerebellar ataxia and autonomic failure. Cardiovascular dysfunction is usually more severe in MSA compared with PD, but some PD patients may present with severe orthostatic hypotension even in the early stages, similar to MSA patients. The presence of orthostatic hypotension alone does not distinguish MSA from PD.52 Bladder symptoms, severe voiding symptoms and an excess of 100 ml of residual urine frequently precede postural symptoms in MSA, and they may also precede the development of motor symptoms.76 The incidence of constipation is less in MSA compared with PD.77. With regard to autonomic tests, most MSA patients show normal myocardial MIBG accumulation, which is useful to differentiate MSA from PD. Previous studies using myocardial MIBG scintigraphy to distinguish PD patients from MSA patients showed sensitivity of 89% and specificity of 77%.34 The clonidine growth hormone stimulation test may also be useful for ...
TY - JOUR. T1 - Cardiac adrenergic nerve function in patients with cardiac syndrome X. AU - Di Monaco, Antonio. AU - Bruno, Isabella. AU - Calcagni, Maria Lucia. AU - Nerla, Roberto. AU - Lamendola, Priscilla. AU - Barone, Lucy. AU - Scalone, Giancarla. AU - Mollo, Roberto. AU - Coviello, Ilaria. AU - Bagnato, Antonio. AU - Sestito, Alfonso. AU - Giordano, Alessandro. AU - Lanza, Gaetano A.. AU - Crea, Filippo. PY - 2010/3. Y1 - 2010/3. N2 - Background: We previously found a severe impairment of cardiac uptake of I-metaiodobenzylguanidine (MIBG), an analogue of norepinephrine, on myocardial scintigraphy in a small group of patients with cardiac syndrome X (CSX), suggesting a dysfunction of cardiac adrenergic nerve fibres. In this study, we assessed the consistency of these previous findings in a larger group of these patients. Methods: Planar and single-photon emission computed tomography MIBG myocardial scintigraphy was performed in 40 CSX patients (58 ± 7 years, 17 men). Cardiac MIBG uptake ...
There is currently no curative treatment for children with relapsed/refractory neuroblastoma, and for these children the 5 year survival rate is
Introduction: Postural tachycardia syndrome (POTS) is a disorder of orthostatic intolerance characterized by excessive tachycardia of unknown etiology. Our objective in this study was to evaluate the correlation between C-fiber involvement as shown by skin biopsy and adrenergic cardiac metaiodobenzylguanadine (MIBG) uptake in POTS patients. Methods: Skin biopsies of 84 patients with POTS were examined by Protein Gene Product 9.5 (PGP9.5) immunohistochemistry and were compared with MIBG myocardial scintigraphy imaging data. Results: Mean intraepidermal nerve fiber (IENF) density was in the lower normal age-adjusted range, 7.2 ± 2.9/mm (normal ≥7/mm), and was slightly below the normal range in 45% of POTS patients. MIBG uptake was reduced in 21% of patients. Low IENF density correlated with reduced cardiac MIBG uptake (r = 0.39, P = 0.001). Conclusions: A subset of neuropathic POTS patients may harbor mild small fiber neuropathy with abnormalities of unmyelinated nerve fibers in the skin ...
Excess secretion of any of the adrenal cortical or medullary hormones contributes to a number of well-known clinical syndromes.. They may result from benign or malignant adrenal tumours, adrenal hyperplasia or, least frequently, from extra-adrenal disease. Differentiation among these possibilities is often impossible on clinical or biochemical grounds alone. Location of the site(s) of excess hormone production in the past depended on relatively insensitive or invasive radiological methods. The non-invasive evaluation began with X-ray computed tomography but the functional significance of anatomical abnormalities cannot be determined from CT scan. Incorporation of specific radiopharmaceuticals into the abnormal tissues allows scintigraphic localization of functional abnormalities with a high degree of efficacy. The combination of adrenal scintigraphy and kompjuterizovanom tomografijom CT or magnetskom rezonancijom MRI should in most cases obviatc the need for more invasive procedures. Phaeochromocytoma
Iobenguane, also known as metaiodobenzylguanidine or mIBG, or MIBG (tradename Adreview) is a radiopharmaceutical, used in a scintigraphy method called MIBG scan. Iobenguane is a radiolabeled molecule similar to noradrenaline. The radioisotope of iodine used for the label can be iodine-123 (for imaging purposes only) or iodine-131 (which must be used when tissue destruction is desired, but is sometimes used for imaging also). It localizes to adrenergic tissue and thus can be used to identify the location of tumors such as pheochromocytomas and neuroblastomas. With I-131 it can also be used to eradicate tumor cells that take up and metabolize norepinephrine. Thyroid blockade with (nonradioactive) potassium iodide is indicated for nuclear medicine scintigraphy with iobenguane/mIBG. This competitively inhibits radioiodine uptake, preventing excessive radioiodine levels in the thyroid and minimizing the risk of thyroid ablation ( in the case of I-131). The minimal risk of thryoid carcinogenesis is ...
Granulating and coating machine | I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent | Patient medical information and education container | Ether carbinols | Ether carbinols, process for preparing same, products produced according to said processes containing said... |
The purpose of this research study is to evaluate an investigational drug (DFMO) in combination with bortezomib, for relapsed and refractory neuroblastoma. DFMO is an investigational drug because it has not been approved by the U.S. Food and Drug Administration (FDA). This study will look at the safety and tolerability of DFMO in combination with bortezomib as well as the tumors response to this study drug.
Earlier we demonstrated that meta-iodobenzylguanidine (MIBG), a specific inhibitor of arginine mono-ADP-ribosylation blocks proliferation and differentiation of chick skeletal myogenic cells in...
Goggin JM, Hoskinson JJ, Carpenter JW, et al. Vet Radiol Ultrasound 1997;38:211-220. To assess the role of scintigraphic evaluation of distal limb perfusion,
This study focuses on patients who have symptoms that are the precursors of Parkinsons disease (PD), PD, or types of atypical PD.
Can you name the Sympathetic Innervations of the Abdomen? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by ezhang
Aktienempfehlung vom 27.02.20: Die Experten der JP Morgan Chase & Co. bewerten die Aktie von Hennes & Mauritz AB (H & M, H&M mit overweight.
Jatrorrhizine 是一种有效的口服活性 uptake-2 transporter 抑制剂,可以从各种中药植物中分离出来。 Jatrorrhizine 通过抑制 HT22 海马神经元中的 MAPK 途径,在 H2O2 诱导的细胞凋亡中发挥关键的神经保护作用 ...
Figure 6. Functional remodeling of cardiac innervation in an experimental infarct model and humans with postinfarct cardiomyopathy. Innervation patterns of the mammalian heart are altered after myocardial infarction. Left upper, Polar maps of global epicardial activation recovery intervals (ARIs) recorded from a control and an infarcted porcine heart at baseline (BL), and during stimulation of the right, left, and bilateral stellate ganglion (RSG, LSG, and BSG, respectively). The focal region of myocardial infarction in the anteroapical left ventricle is indicated by the dashed circle in bottom row. The altered pattern of ARI distribution in the infarcted heart extends beyond the region of focal myocardial infarction. Right upper, Graphical representation of the regional responses of the porcine heart to stimulation of RSG, LSG, and BSG in control and infarcted hearts, respectively. The anterior and posterior predominance of RSG and LSG stimulations, respectively, are completely lost after ...
There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has b
As a research tool, cardiac adrenergic nervous system scintigraphy with I-123-meta-iodo-benzyl-guanidine (MIBG) has been widely applied.. In addition to cardiac studies, gamma camera SYMBIA INTEVO EXCEL (SPECT-CT) offers a wide range of other nuclear medicine tests. All types of clinical acquisitions are performed: static and dynamic planar examinations, whole body scans, organ SPECT tests, SPECT-CT studies with attenuation correction and with improved lesion localization. Performed scintigraphic studies include:. ...
Happy Anniversary - well, technically Im two days late This is going to be a bit of a big update, even for me, Ive been holding back a bit it seems It was a year ago that I learned I had pheochromocytoma again. It was just after that I learned it was malignant pheochromocytoma cancer.…
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Researchers have discovered details of the abnormal molecular signals and biological events that drive a high-risk form of the childhood cancer neuroblastoma. Having investigated a signaling network involving three cancer-causing genes, the scientists aim to use these findings to develop more effective targeted treatments.
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A total body iodine-131 scan demonstrates severe, widespread iodine avid metastatic disease seen in the thyroid lungs (red arrow), right (blue arrow) and left (
Some days our skin needs a little extra moisture and other days we need a cleansing mask. Then there are days when we need all the help we can get.
TY - JOUR. T1 - Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias. AU - Gardner, R. T.. AU - Wang, L.. AU - Lang, B. T.. AU - Cregg, J. M.. AU - Dunbar, C. L.. AU - Woodward, William. AU - Silver, J.. AU - Ripplinger, C. M.. AU - Habecker, Beth. PY - 2015. Y1 - 2015. N2 - Millions of people suffer a myocardial infarction (MI) every year, and those who survive have increased risk of arrhythmias and sudden cardiac death. Recent clinical studies have identified sympathetic denervation as a predictor of increased arrhythmia susceptibility. Chondroitin sulfate proteoglycans present in the cardiac scar after MI prevent sympathetic reinnervation by binding the neuronal protein tyrosine phosphatase receptor σ (PTPσ). Here we show that the absence of PTPσ, or pharmacologic modulation of PTPσ by the novel intracellular sigma peptide (ISP) beginning 3 days after injury, restores sympathetic innervation to the scar and ...
TY - JOUR. T1 - Scintigraphic assessment of alterations in cardiopulmonary haemodynamics and renal functional activity in patients with endured coronary artery bypass grafting. AU - Vesnina, Zh V.. AU - Krivonogov, N. G.. AU - Vecherskiĭ, Iu Iu. AU - Lishmanov, Iu B.. PY - 2015. Y1 - 2015. N2 - OBJECTIVE: By means of scintigraphic methods to assess alterations in cardiopulmonary haemodynamics and renal functional activity in patients with coronary artery disease (CAD) after endured coronary artery bypass grafting (CABG) performed in conditions of extracorporeal circulation (EC) and on the functioning heart.MATERIAL AND METHODS: We examined a total of 40 patients presenting with CAD (mean age 54.90±1.12 years) after endured CABG. All patients were subdivided into 2 groups: Group One consisting of 20 patients subjected to CABG performed on the beating heart with the use of myocardial "stabilizer" "Acrobat" (Study Group) and Group Two also comprising 20 patients but undergoing surgery with the ...
Embolization therapy. Embolization therapy is a treatment to block the artery leading to the adrenal gland. Blocking the flow of blood to the adrenal glands helps kill cancer cells growing there.. Targeted therapy. Targeted therapy is a treatment that uses drugs or other substances to identify and attack specific cancer cells without harming normal cells. Targeted therapies are used to treat metastatic and recurrent pheochromocytoma. Sunitinib (a type of tyrosine kinase inhibitor) is a new treatment being studied for metastatic pheochromocytoma. Tyrosine kinase inhibitor therapy is a type of targeted therapy that blocks signals needed for tumors to grow. New types of treatment are being tested in clinical trials. Information about clinical trials is available from the NCI website.. Treatment for pheochromocytoma and paraganglioma may cause side effects.. For information about side effects caused by treatment for cancer, see our Side Effects page.. Patients may want to think about taking part in ...
As far as we know, this study is the first to examine the effect of permanent dual chamber pacing on myocardial perfusion and adrenergic innervation before and after pacemaker implantation in humans.. Ventricular pacing through the right ventricular apex-although the site is easily accessible and traditionally used for electrode implantation-results in asynchronous ventricular activation.13 During the last few years, "normalisation" of ventricular electrical stimulation in paced patients has acquired considerable importance. Other researchers have suggested that ventricular pacing decreases fibre shortening, contractile work, and myocardial blood flow in early activated regions and increases these indices in late activated regions.14 It is also known that long term asynchronous electrical activation leads to asymmetrical changes of left ventricular wall mass induced by regional changes of mechanical load, with the early activated regions having a lower preload than the late activated regions. ...
The form The SOAS-Royal Geographical Society (with IBG) Scholarship for Masters Study on Urban Population Growth in Somaliland is no longer accepting responses ...
Strong positive staining (+++) of the malignant pheochromocytoma (top left),++ of the paraganglioma (top right),+ of the benign pheochromocytoma (bottom left),
Fashion pictures or video of Natasha Poly: H&M Conscious Collection 2011 Spring; in the fashion photography channel Advertising.
For parents and caregivers of children with high-risk neuroblastoma with books featuring Skivolo, information, education, resources, help, and support.
Marketing Principles H&M Assignment: Introduction H&M is a Swedish multinational company involved into the fast fashion products for the men, women and children. H&M at present ...
Arginine adenosine-5′-diphosphoribosylation (ADP-ribosylation) is an enzyme-catalyzed potentially reversible posttranslational changes where the ADP-ribose moiety is transferred from NAD+ towards the guanidino CHR2797 moiety of arginine. proteins with binding companions e.g. toxin-catalyzed ADP-ribosylation of actin at R177 blocks actin polymerization sterically. In case there is the nucleotide-gated P2X7 ion route ADP-ribosylation at R125 near the ligand-binding site causes route Rabbit Polyclonal to SF3B3. gating. Arginine-specific ADP-ribosyltransferases (ARTs) bring a quality R-S-EXE theme that distinguishes these enzymes from structurally related enzymes which catalyze ADP-ribosylation of additional amino acid part chains DNA or little substances. Arginine-specific ADP-ribosylation could be inhibited by little molecule arginine analogues such as for example CHR2797 agmatine or meta-iodobenzylguanidine (MIBG) which themselves can serve as focuses on for arginine-specific ARTs. ...
adrenal malignant paraganglioma Digital case Case 331 (HPC:153) : Peritoneum (adrenal) malignant paraganglioma with lymph node metastases. (...)
My research explores racial, ethnic, and socioeconomic disparities in access to care and outcome of leukemia and lymphoma treatment. I study access to care across the continuum of pediatric cancer from diagnosis and clinical trial enrollment through treatment and relapse to salvage therapies. My research has shown that African American children with acute lymphoblastic leukemia, acute myeloid leukemia, and mature B cell lymphoma are two times more likely to present with organ failure at the time of a new cancer diagnosis. My ongoing work investigates access to highly specialized and complex therapies such as stem cell transplant, chimeric antigen receptor T cells, and MIBG therapy.. ...
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation in high-risk neuroblastoma, we studied 240 affected individuals (cases) using a combination of whole-exome, genome and transcriptome sequencing as part of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative. Here we report a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in these tumors. Genes with significant somatic mutation frequencies included ALK (9.2% of cases), PTPN11 (2.9%), ATRX (2.5%, and an additional 7.1% had focal deletions), MYCN (1.7%, causing a recurrent p.Pro44Leu alteration) and NRAS (0.83%). Rare, potentially pathogenic germline variants were significantly enriched in ALK, CHEK2, PINK1 and BARD1. The relative paucity of recurrent somatic mutations in ...
Thermo Fisher Scientific Inc. has received clearance from the U.S. Food and Drug Administration (FDA) that expands the clinical claims of the Thermo Scientific B·R·A·H·M·S PCT (Procalcitonin) biomarker assay for sepsis risk assessment. Clinicians can now use B·R·A·H·M·S PCT to help assess the response of septic patients to treatment by comparing a baseline PCT measurement with a PCT value taken on day four.. B·R·A·H·M·S PCT cleared for assessing mortality risk of septic patients ›. ...
I told the Dr. please prepare 3 sets of scans and paperwork for us to pick up Monday! Immediately Doug and I started to worry and worry about Emilys total well being with much of the constant back and forth from Emilys doctor and what they believe and what they dont believe of her spots. From the beginning it was of concern that maybe it wasnt neuroblastoma because the spots was symmetric on both legs in the same spots and tried several other varieties of scans to see if they could figure this one out, and everything they did didnt turn out with the answer they were looking for. For us, it was an immediate second opinion back in early January and VCU Medical Center waited to hear what Sloan Kettering had to say and how they would stage it. VCU Medical Center staged Emily Stage IV based off of Sloan, because once Sloan looked at it there was no question to them that these spots in her iliac wings and femurs were metastatic disease, so VCU Medical Center followed what Sloan went with. Each ...
I told the Dr. please prepare 3 sets of scans and paperwork for us to pick up Monday! Immediately Doug and I started to worry and worry about Emilys total well being with much of the constant back and forth from Emilys doctor and what they believe and what they dont believe of her spots. From the beginning it was of concern that maybe it wasnt neuroblastoma because the spots was symmetric on both legs in the same spots and tried several other varieties of scans to see if they could figure this one out, and everything they did didnt turn out with the answer they were looking for. For us, it was an immediate second opinion back in early January and VCU Medical Center waited to hear what Sloan Kettering had to say and how they would stage it. VCU Medical Center staged Emily Stage IV based off of Sloan, because once Sloan looked at it there was no question to them that these spots in her iliac wings and femurs were metastatic disease, so VCU Medical Center followed what Sloan went with. Each ...
neuroblastoma - MedHelps neuroblastoma Center for Information, Symptoms, Resources, Treatments and Tools for neuroblastoma. Find neuroblastoma information, treatments for neuroblastoma and neuroblastoma symptoms.
Ankle-length cargo trousers in washed, stretch cotton twill with a regular waist, zip fly and button, front and back pockets and flap leg pockets with a but
are located right above the kidneys and make hormones including stress hormones called epinephrines and norepinephrines. Pheochromocytomas increase the production of these hormones, leading to hypertension (high blood pressure) and symptoms such as headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain or anxiety. When this type of tumor occurs outside the adrenal gland, it is called a paraganglioma. Metastatic pheochromocytoma and paraganglioma may result in unresectable disease with a poor prognosis, including a five-year survival rate as low as 12%. Treatment options for patients with this disease type were very limited prior to this approval.. "Many patients with these ultra-rare cancers can be treated with surgery or local therapies, but there are no effective systemic treatments for patients who experience tumor-related symptoms such as high blood pressure," said Richard Pazdur, M.D., director of the FDAs Oncology Center of Excellence and ...
RiTradiology.com ดูแลรักษาโดยและเป็นของ น.พ.รัฐชัย แก้วลาย. โลโก้ RiTradiology.com เป็นลิขสิทธิ์ของ น.พ.รัฐชัย แก้วลาย. ข้อมูลส่วนตัวของคุณถือเป็นความลับและจะไม่ถูกเผยแพร่ไปยังบุคคลที่สาม. ข้อมูลใน RiTradiology.com ใช้เป็นแนวทาง, ไม่ใช่เพื่อทดแทน, การให้การวินิจฉัย, รักษาและคำแนะนำสำหรับผู้ป่วย. แพทย์ของคุณอาจให้คำแนะนำในการวินิจฉัยหรือรักษาเป็นอย่างอื่นขึ้นกับข้อมูลและสถานการณ์นั้นๆ. ...
Two-year-old Victoria Thompson is part of the national precision medicine trial Peds PLAN through MUSC Childrens Health for children with high-risk neuroblastoma. Shes also receiving DFMO, a drug normally used to treat African sleeping sickness that may help keep high-risk neuroblastoma thats in remission from recurring.
iodine-131 definition: (medication) The radioactive isotope of iodine, 13153I, having a half-life of 8 times; made use of as a medical tracer; heavy radioactive isotope of iodine with a half-life of 8…
Learn more about Pheochromocytoma at Cartersville Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Pheochromocytoma - Pipeline Review, H2 2016, provides an overview
Drug-resistance is an important factor of failure to cure patients with high-risk neuroblastoma, and little is known of the contribution of the microenvironment...
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Aand Im back with yet another #OOTD (Outfit of the Day) post, featuring a hella lotta uber recent Boohoo purchases with a touch of H&M and Miss Guided. I must say I couldnt resist this bomber jacket when I saw it on the Boohoo site, so I just had to pick it up! Take a look at the full look below and drop a comment to let me know what you think ...
Expression of the noradrenaline transporter (NAT) was examined in normal human adrenal medulla and phaeochromocytoma by using immunohistochemistry and confocal microscopy. The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) were used as catecholamine biosynthetic markers and chromogranin A (CGA) as a marker for secretory granules. Catecholamine content was measured by using high performance liquid chromatography (HPLC). In normal human adrenal medulla (n=5), all chromaffin cells demonstrated strong TH, PNMT and NAT immunoreactivity. NAT was co-localized with PNMT and was located within the cytoplasm with a punctate appearance. Human phaeochromocytomas demonstrated strong TH expression (n=20 samples tested) but variable NAT and PNMT expression (n=24). NAT immunoreactivity ranged from absent (n=3) to weak (n=10) and strong (n=11) and, in some cases, occupied an apparent nuclear location. Unlike the expression seen in normal human adrenal medullary tissue, NAT ...
1. In six healthy subjects the role of renal prostaglandins (PG) in modulating the actions of the renin-angiotensin and renal adrenergic nervous systems on renal function was investigated.. 2. During high dietary sodium intake (350 mmol/day) for 4 days no changes in urinary excretion of PGE2, PGF2α, noradrenaline or adrenaline were noted, whereas plasma renin activity (PRA) and urinary aldosterone excretion were suppressed.. 3. After 4 days of low sodium intake (35 mmol/day) urinary excretion of PGE2, aldosterone and noradrenaline, as well as PRA, had significantly increased.. 4. Inhibition of PG synthesis with indomethacin (2 mg/kg body weight) had no effects on renal function on day 5 of high sodium intake. Despite suppression of PRA and urinary aldosterone, indomethacin significantly reduced p-aminohippurate (PAH) clearance, glomerular filtration rate (GFR) and urinary sodium excretion on day 5 of low sodium intake, when urinary noradrenaline excretion remained high.. 5. The results point to ...
Pheochromocytoma is a rare tumor of the adrenal gland. It often presents with the classic triad of headache, palpitations and generalized sweating. Although not described as a typical symptom of pheochromocytoma, anxiety is the fourth most common symptom reported by patients suffering of pheochromocytoma. We report the case of a 64 year old man who had severe anxiety and panic disorder as presenting symptoms of pheochromocytoma. After 13 years of psychiatric follow-up, the patient was diagnosed with malignant pheochromocytoma. After surgical resection of his pheochromocytoma and his hepatic metastases, the major panic attacks completely disappeared, the anxiety symptoms improved significantly and the psychiatric medications were stopped except for a very low maintenance dose of venlafaxine. We found in our cohort of 160 patients with pheochromocytoma 2 others cases of apparently benign tumors with severe anxiety that resolved after pheochromocytoma resection. These cases highlight that ...
The single most important tool for the development of high specific activity or no-carrier-added (nca) radiopharmaceuticals is a radio-HPLC. The reason for making such a strong statement in favor of...
Extensive programmed cell death (PCD) occurs in the developing nervous system. Neuronal death occurs, at least in part, because neurons are produced in excess during development and compete with each other for the limited amounts of the survival-promoting trophic factors secreted by target tissues. Neuronal death is apoptotic and utilizes components that are conserved in other PCD pathways. In this review, we discuss the mechanism of trophic factor-dependent neuronal cell death by focusing on the pathway of nerve growth factor (NGF) deprivation-induced sympathetic neuronal death. We describe the biochemical and genetic events that occur in NGF-deprived sympathetic neurons undergoing PCD. Participation of the Bcl-2 family of proteins and the interleukin-1β-converting enzyme family of proteases (caspases) in this and other models of neuronal death is also examined. The order and importance of these components during NGF deprivation-induced sympathetic neuronal death are discussed.. ...
Transport systems for organic compounds are immature in the kidney of most newborn animals. Measured in vitro, uptake of p-aminohippuric acid (PAH) into renal cortical slices is low in tissue from 2-week-old rabbits, peaks at 4 weeks and declines to adult levels. To minimize limitations encountered with the slice technique, a separated tubule preparation was employed to estimate transport. Segments of proximal tubules were prepared by incubating renal cortex in 0.375% collagenase-Ringer solution. The tubules were washed, filtered, suspended in a Ringer-acetate solution containing dilute PAH, oxygenated and incubated at 25°C. The tubules from young animals consumed oxygen to the same extent as those from adult. Intracellular concentrations of sodium and potassium were similar at each age tested. Maximal PAH uptake (T/M ratio) was Obtained after approximately 30 minutes of incubation in tissue from animals of all ages. Adult T/M ratios were significantly higher in the presence of acetate. The ...
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B·R·A·H·M·S PAPP-A KRYPTOR assay is indicated to be used in conjunction with additional clinical data as an aid in assessing the risk of fetal trisomy 21, 18 and 13, and the risk for developing pre-eclampsia in first trimester screening of pregnant women.. ...
Malignant pheochromocytoma associated with pseudo-obstruction of the colon. Murakami, Soichi; Okushiba, Shun-ichi; Ohno, Koichi; Ito, Kiyotaka; Satou, Kousaku; Sugiura, Hiroshi; Morikawa, Toshiaki; Furukawa, Koji; Kondo, Satoshi; Katoh, Hiroyuki; Nihei, Kazuyoshi // Journal of Gastroenterology;2003, Vol. 38 Issue 2, p175 Effective treatment has not yet been established for intestinal pseudo-obstruction, a rare complication of malignant pheochromocytoma. We report the case of a 41-year-old man who presented with malignant pheochromocytoma associated with pseudo-obstruction of the colon. His serum catecholamine... ...
Paraganglioma is a rare cancer that originates in the nerve cells of the adrenal glands, organs on top of each kidney that produce important hormones. Paraganglioma that develops in the center of the adrenal gland is called pheochromocytoma. Paraganglioma that forms outside of the adrenal gland, often along blood vessels and nerves in the head and neck, is called extra-adrenal paraganglioma, or simply paraganglioma.. Each year, between 2 and 8 people per million worldwide are diagnosed with paraganglioma and pheochromocytoma.1 Ten percent of all cases occur in children.2 In both adults and children, pheochromocytoma is more common than paraganglioma.2 No known environmental, dietary, or lifestyle risk factors have been associated with these cancers. However, paraganglioma and pheochromocytoma can be hereditary diseases:3 one study reported that about 41 percent of patients diagnosed with one of these diseases in the U.S. carry inherited genetic mutations that increase the risk of malignancy.1 ...
5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH ... 3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ... vitamin k 3 MeSH D02.455.849.291.850 --- taxoids MeSH D02.455.849.291.850.777 --- paclitaxel MeSH D02.455.849.365 --- dolichol ... 3-diketogulonic acid MeSH D02.241.081.844.300 --- glucaric acid MeSH D02.241.081.844.322 --- gluconates MeSH D02.241.081.844. ...
Iodobenzylguanidine. J Nucl Med 25:2-6, 1984 "Medical isotopes the likely cause of radiation in Ottawa waste". CBC News. 4 ... 81 (8): 2930-3. doi:10.1210/jc.81.8.2930. PMID 8768854. Lawrence, J. E.; Lamm, S. H.; Pino, S.; Richman, K.; Braverman, L. E. ( ... The majority of I-131 will be eliminated from the human body in 3-5 days, through natural decay, and through excretion in sweat ... 1 (3): 197-203. doi:10.1023/A:1010031115233. ISSN 1389-9155. PMID 11705004. Frot, Jacques. "THE CAUSES OF THE CHERNOBYL EVENT ...
... meta-iodobenzylguanidine), which is taken up by 90 to 95% of all neuroblastomas, often termed "mIBG-avid." The mechanism is ... ISBN 978-3-540-26616-7. Beckwith, J. Bruce; Perrin, Eugene V. (1963). "In Situ Neuroblastomas: a Contribution to the Natural ... Stage 3: Tumor infiltrating across midline with or without regional lymph node involvement; or unilateral tumor with ... The degree of amplification shows a bimodal distribution: either 3- to 10-fold, or 100- to 300-fold. The presence of this ...
I131-MIBG (m-iodobenzylguanidine) Neuroectodermal tumor imaging IV In-vivo Imaging TherapeuticEdit. Name Treatment of Route of ... I123-MIBG (m-iodobenzylguanidine) Neuroectodermal tumour imaging IV In-vivo Imaging I123-FP-CIT SPECT imaging of Parkinson's ... Hydrogen-3Edit. 3H or tritium is a beta emitter. Name Investigation Route of administration In-vitro / in-vivo Imaging / non- ...
... meta-iodobenzylguanidine (MIBG) imaging for neuroendocrine tumors, heat-damaged red blood cell imaging for identifying ectopic ... 1996 Jul;26(3):191-193. PMID 8829280. PET center of excellence ABNM brochure nuclear medicine technologists American Board of ...
I-123 MIBG (meta-iodobenzylguanidine). *Patient preparation include: suspend all medications that could interfere with MIBG ...
Buscombe JR, Cwikla JB, Caplin ME, et al.: Long-term efficacy of low activity meta-[131I]iodobenzylguanidine therapy in ... 2] [3] Pheochromocytoma is present in 0.1% to 1% of patients with hypertension, [4] [5] [6] and it is present in approximately ... 1] [2] [3] [4] [5] [6] [7]. References: * Plouin PF, Chatellier G, Fofol I, et al.: Tumor recurrence and hypertension ... Nat Genet 42 (3): 229-33, 2010.. * Neumann HP, Pawlu C, Peczkowska M, et al.: Distinct clinical features of paraganglioma ...
Does iodine-131 meta-iodobenzylguanidine (MIBG) scintigraphy have an impact on the management of sporadic and familial ... Arch Fam Med 1994; 3:55.. *Sawka AM, Jaeschke R, Singh RJ, Young WF Jr. A comparison of biochemical tests for pheochromocytoma ... 3]. However, this is likely to be an underestimate as 50 percent of pheochromocytomas were diagnosed at autopsy in one series [ ...
Cardiac Resynchronization and Iodine Meta-Iodobenzylguanidine (MIBG) Imaging. The safety and scientific validity of this study ... 3-Iodobenzylguanidine. Anti-Infective Agents, Local. Anti-Infective Agents. Trace Elements. Micronutrients. Growth Substances. ... and 3) by performing a special heart scan. ...
2-(2-Iodobenzyl)guanidine *Molecular FormulaC8H10IN3. *Average mass275.090 Da ...
3-Iodobenzylguanidine. Anti-Infective Agents, Local. Anti-Infective Agents. Trace Elements. Micronutrients. Growth Substances. ...
I-131 meta-iodobenzylguanidine. Detailed Description: Neuroblastoma, pheochromocytoma, and paraganglioma remain fatal diseases ... 3-Iodobenzylguanidine. Antineoplastic Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Patients with active infections that meet grade 3-4 according to the NCI CTCAE v3.0. ...
Once that is achieved CBC will be then obtained on day 56 and then every 3 months until 1 year post treatment, then every 6 ... Disease response will be assessed at day 56 +/- 14 days and then every 3 months until 1 year post therapy or initiation of ... 3-Iodobenzylguanidine. Iodine. Antineoplastic Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Monoclonal antibodies: At least 3 half-lives should have elapsed since therapy with a monoclonal antibody ...
3-Iodobenzylguanidine. Antineoplastic Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Patients will require hospitalization for treatment and will remain hospitalized for about 3-6 days. ...
Patients are 3 years of age and older with relapsed or refractory neuroblastoma who are currently enrolled on a treatment ... Patients are 3 years of age and older with relapsed or refractory neuroblastoma who are currently enrolled on a treatment ... Assessment of the accuracy of tumor imaging using 124I-MIBG PET/CT versus 123I-MIBG scan with 3-dimensional imaging by SPECT or ... Age: Patients must be ,/= 3 years of age and able to cooperate for the PET CT scan when registered on study. ...
This clinical trial is studying induction therapy followed by meta-iodobenzylguanidine (MIBG) labeled with iodine-131 and ... an induction block of meta-iodobenzylguanidine labeled with iodine-131 (131I-MIBG [iobenguane I 131]) delivered after multi- ... Course 3 and 5: Patients receive cisplatin IV over 1 hour on days 1-4 and etoposide phosphate IV over 1-2 hours on days 1-3. ... After completion of study therapy, patients are followed up every 3 months for 1 year, every 6 months for 4 years, and then ...
This clinical trial is studying induction therapy followed by meta-iodobenzylguanidine (MIBG) labeled with iodine-131 and ... Patients that are 12-18 months of age with INSS stage 4 and all 3 favorable biologic features (i.e., non-amplified MYCN, ... Patients with newly diagnosed neuroblastoma with INSS stage 3 are eligible with the following:. *MYCN amplification (, 4-fold ... 3-Iodobenzylguanidine. Isotretinoin. Immunosuppressive Agents. Immunologic Factors. Physiological Effects of Drugs. ...
3-Iodobenzylguanidine. Antineoplastic Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ...
3-Iodobenzylguanidine. Anti-Infective Agents, Local. Anti-Infective Agents. Trace Elements. Micronutrients. Nutrients. Growth ... The catheter will be removed 3-5 days following the treatment. General anesthesia or sedation is typically given for the ...
2006 Jan 20;24(3):500-6. Prigione I, Corrias MV, Airoldi I, Raffaghello L, Morandi F, Bocca P, Cocco C, Ferrone S, Pistoia V. ... 3-Iodobenzylguanidine. Antineoplastic Agents. Immunologic Factors. Physiological Effects of Drugs. Antirheumatic Agents. ...
3-Iodobenzylguanidine. Antineoplastic Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... 2-5 days with an expected mean 3 days) and after recovery of cardiac function (6 weeks) ]. Number of participants who had an ...
... in combination with standard radiation therapy Iodine-131 labelled Meta-iodobenzylguanidine (131I-mIBG). ... Estimated life expectancy , 3 months.. *Adequate bone marrow function: Haemoglobin ≥ 100 g/L, White Blood Cell ≥ 3.0 x 10^9/L, ... Assessment will be determined using CT scans and 123I-mIBG scans performed at baseline, then every 3 months after start of ... No previous systemic chemotherapy within 3 months prior to registration. *No previous mIBG therapy within 12 months prior to ...
Received Day: 22 Month: 3 Year: 2012. Accepted Day: 25 Month: 6 Year: 2012. Electronic publication date: Day: 18 Month: 7 Year ... 3). Also, the wash-out rate was significantly higher in these patients (−3.3 ± 9.9 % vs. 17 ± 10 %, p , 0.001; Fig. 4). There ... 3.. Klein AL,Hatle LK,Taliercio CP,Taylor CL,Kyle RA,Bailey KR,et al. Serial Doppler echocardiographic follow-up of left ... Table 3 summarizes the echocardiographic examination results. Left and right ventricular wall thickness was overall normal in ...
3-Iodobenzylguanidine / diagnostic use*. Adenosine / diagnostic use. Aged. Autonomic Nervous System Diseases / etiology*. ...
f) electron deficient aromatic rings suitable for nucleophilic iodination, such as hippurate and 2-iodobenzylguanidine. ... Preferred tropane derivatives are 123I-CIT (Dopascan™), 123I-CTT-FP (DaTSCAN™) and the E isomer of 123I-2β-carbomethoxy-3 β-(4- ... Such reaction vessels are preferably 1 to 10 cm3, most preferably 2 to 5 cm3 in volume and are configured such that 3 or more ... The method of any one of Claims 1 to 3, where the biological targeting molecule is chosen from: a tropane, a fatty acid, a ...
doi: 10.1007/s13139-018-0523-z. Epub 2018 May 3. Nucl Med Mol Imaging. 2018. PMID: 30100938 Free PMC article. Review. ...
EANM procedure guidelines for 131I-meta-iodobenzylguanidine (131I-mIBG) therapy. Eur J Nucl Med Mol Imaging. 2008;35(5):1039-47 ... Table 3 Summary of reported cases of therapeutic radiopharmaceutical extravasation. Full size table. ... 3.. Silberstein EB, Buscombe, J.R., McEwan, A., Taylor, A.T.Jr.,.Society of Nuclear Medicine Procedure Guideline for Palliative ... 42-44]. Particularly the long period of 2 and 3 years after 201Th-thallous chloride raise questions whether the skin lesions ...
Phosphoric Acids: 3*Phosphates: 1226*Polyphosphates: 112*Diphosphates: 62*Technetium Tc 99m Pyrophosphate: 172*technetium Tc ... 3. Amyloidosis 07/01/1993 - "[Technetium TC 99m pyrophosphate myocardial scintigraphy in amyloidosis. ". 01/01/1990 - "Soft- ... 99mTc-Pyrophosphate; Diphosphoric Acid, Technetium Salt; Tc-PYP; Technetium Tc 99m Pyrophosphate, Tc(3+) Salt (3:4); Technetium ...
3. Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2012 - 06/2005. 3. Rhabdoid Tumor (Rhabdoid Tumors) 09/2011 - 09/2004 ... 3-Iodobenzylguanidine (Iobenguane)IBA 07/2012. 1. 6- acetyl- 8- cyclopentyl- 5- methyl- 2- (5- piperazin- 1- ylpyridin- 2- ... ylamino)- 8H- pyrido(2,3- d)pyrimidin- 7- oneIBA 09/2011. ...
3. Technetium Tc 99m Sestamibi (Cardiolite)FDA LinkGeneric 01/2006 - 11/2003. ...
  • For example, truncating germline mutations in the transmembrane-encoding gene TMEM127 on chromosome 2q11 have been shown to be present in approximately 30% of affected patients with familial disease and in about 3% of patients with apparently sporadic pheochromocytomas without a known genetic cause. (uni-bonn.de)
  • There has been a significant movement recently in a rather stagnant field of cardiovascular radionuclide imaging in the U.S. Two relatively large prospective clinical studies have just been completed with 123 I-labeled beta-methyl-p-iodophenyl-pentadecanoic acid and 123 I-labeled meta -iodobenzylguanidine ( m IBG) for the assessment of ischemic memory and neuronal dysfunction, respectively. (onlinejacc.org)
  • Hirayama M, Hakusui S, Koike Y, Ito K, Kato T, Ikeda M, Hasegawa Y, Takahashi A (1995) A scintigraphical qualitative analysis of peripheral vascular sympathetic function with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure. (springer.com)
  • We performed brain MRI and 123 I-FP-CIT SPECT in all and in 3 additional patients carrying the same mutation but without parkinsonism. (ahajournals.org)
  • However, it has been shown that pacing through the right ventricular apex is associated with alterations in the contraction and relaxation pattern of the left ventricle, 1- 3 remodelling, and histological abnormalities in the left ventricular myocardium. (bmj.com)
  • The goals of this part of the study are: To determine if the investigators tumor board committee (at minimum a panel of 3 oncologists and 1 pharmacist) can use patient specific cancer cells to make real-time treatment decision using patient specific genetic information, and predicted therapies generated in the Xenobase report. (clinicaltrials.gov)
  • Via its incorporation into more than two dozen selenoproteins throughout the body, 2,3 selenium provides potent defense against cancer-causing DNA damage , 4,5 facilitates removal of dangerous toxins from the body, 6 supports optimal thyroid function, 7 maintains immune system activity, 3,8,9 and much more. (lifeextension.com)
  • 3 To control and terminate these effects, there is active NE reuptake into presynaptic terminals, mostly via the norepinephrine transporter-1 (NET1) membrane protein, for storage or catabolic metabolism. (acc.org)
  • NYHA class, 6-minute walk distance, echocardiographic parameters, plasma norepinephrine (NE) were assessed at baseline, 3-month and 6-month follow-up. (elsevier.com)
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. (duke.edu)
  • Additionally preferred are compounds wherein R 1 and R 2 both are hydrogen, and R 3 and R 4 both are ethyl, and R 5 is a normal-C 6 -C 10 alkyl group. (google.ca)
  • J., 133, pp. 529-539 (1973), reported that the N-hydroxysuccinimide ester of 3-(4-hydroxyphenyl)-propionic acid- 125 I is useful to radio-label proteins. (google.ca)