Hydroxysteroid Dehydrogenases
17-Hydroxysteroid Dehydrogenases
20-Hydroxysteroid Dehydrogenases
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.
11-beta-Hydroxysteroid Dehydrogenase Type 2
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
11-beta-Hydroxysteroid Dehydrogenase Type 1
11-beta-Hydroxysteroid Dehydrogenases
Estradiol Dehydrogenases
Sulfotransferases
Cortisone
Steroid 17-alpha-Hydroxylase
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Alcohol Oxidoreductases
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
NAD
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Hydrocortisone
L-Lactate Dehydrogenase
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Androsterone
Liver
Alcohol Dehydrogenase
Glyceraldehyde-3-Phosphate Dehydrogenases
20-alpha-Hydroxysteroid Dehydrogenase
Aldehyde Dehydrogenase
Glutamate Dehydrogenase
Malate Dehydrogenase
Isocitrate Dehydrogenase
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Phosphoadenosine Phosphosulfate
3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.
Arylsulfotransferase
A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.
Ketosteroids
Dihydrolipoamide Dehydrogenase
NADP
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Carbohydrate Dehydrogenases
Succinate Dehydrogenase
L-Iditol 2-Dehydrogenase
Dehydroepiandrosterone
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Substrate Specificity
Glucose 1-Dehydrogenase
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Glucose Dehydrogenases
Phosphogluconate Dehydrogenase
Sugar Alcohol Dehydrogenases
Stereoisomerism
NADH Dehydrogenase
A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.
IMP Dehydrogenase
Amino Acid Sequence
Gene Expression Regulation, Enzymologic
Isoenzymes
Formate Dehydrogenases
Flavoproteins that catalyze reversibly the reduction of carbon dioxide to formate. Many compounds can act as acceptors, but the only physiologically active acceptor is NAD. The enzymes are active in the fermentation of sugars and other compounds to carbon dioxide and are the key enzymes in obtaining energy when bacteria are grown on formate as the main carbon source. They have been purified from bovine blood. EC 1.2.1.2.
Acyl-CoA Dehydrogenase
Xanthine Dehydrogenase
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
A ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO2. The enzyme requires THIAMINE DIPHOSPHATE as a cofactor. Defects in genes that code for subunits of the enzyme are a cause of MAPLE SYRUP URINE DISEASE. The enzyme was formerly classified as EC 1.2.4.3.
Base Sequence
Pyruvate Dehydrogenase (Lipoamide)
3-Hydroxyacyl CoA Dehydrogenases
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Dihydrouracil Dehydrogenase (NADP)
Uridine Diphosphate Glucose Dehydrogenase
Catalysis
Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. (1/633)
We have previously reported that intrabursal ovarian administration of LH at the end of pregnancy in rats induces a decrease in luteal progesterone (P4) synthesis and an increase in P4 metabolism. However, whether this local luteolytic effect of LH is exerted directly on luteal cells or on other structures, such as follicular or stromal cells, to modify luteal function is unknown. The aim of the present study was to determine the effect of LH on isolated luteal cells obtained on Day 19 of pregnancy. Incubation of luteal cells with 1, 10, 100, or 1000 ng/ml of ovine LH (oLH) for 6 h did not modify basal P4 production. The addition to the culture medium of 22(R)-hydroxycholesterol (22R-HC, 10 microgram/ml), a membrane-permeable P4 precursor, or pregnenolone (10(-2) microM) induced a significant increase in P4 accumulation in the medium in relation to the control value. When luteal cells were preincubated for 2 h with oLH, a significant (p < 0.01) reduction in the 22R-HC- or pregnenolone-stimulated P4 accumulation was observed. Incubation of luteal cells with dibutyryl cAMP (1 mM, a cAMP analogue) plus isobutylmethylxanthine (1 mM, a phosphodiesterase inhibitor) also inhibited pregnenolone-stimulated P4 accumulation. Incubation with an inositol triphosphate synthesis inhibitor, neomycin (1 mM), or an inhibitor of intracellular Ca2+ mobilization, (8,9-N, N-diethylamino)octyl-3,4,5-trimethoxybenzoate (1 mM), did not prevent the decrease in pregnenolone-stimulated P4 secretion induced by oLH. It was concluded that the luteolytic action of LH in late pregnancy is due, at least in part, to a direct action on the luteal cells and that an increase in intracellular cAMP level might mediate this effect. (+info)Luteinization and proteolysis in ovarian follicles of Meishan and Large White gilts during the preovulatory period. (2/633)
This experiment was conducted to determine why follicles luteinize faster in the Meishan breed than in the Large White breed of pig. Follicles were recovered during the late follicular phase from ovaries of both breeds before and after administration of hCG given to mimic the LH surge. First, the patterns of cholesterol transporters (high and low density lipoproteins: HDL and LDL) were compared. Cholesterol transporters detected in follicular fluid consisted of HDL only. Similar amounts of Apolipoprotein A-I were found in all samples. There was no obvious breed effect on minor lipoproteins found in the HDL-rich fraction, and this pattern was altered similarly by hCG in the two breeds. The LDL-rich samples of serum from both breeds contained similar amounts of protein. Second, three steroidogenic enzymes, adrenodoxin, 17 alpha-hydroxylase-lyase (P450(17) alpha) and 3 beta-hydroxysteroid-dehydrogenase (3 beta-HSD) were detected by immunohistochemistry and quantified by image analysis on sections of the two largest follicles. Before hCG treatment, theca interna cells demonstrated immunoreactivities for adrenodoxin (strong), P450(17) alpha and 3 beta-HSD (very strong), whereas granulosa cells displayed immunoreactivities for adrenodoxin only. After hCG treatment, the localization of the enzymes was unchanged but the staining intensity of adrenodoxin on granulosa cells and 3 beta-HSD on theca cells increased (P < 0.01 and P < 0.05, respectively). Breed effects were detected for the amounts of adrenodoxin in theca cells (Meishan > Large White; P < 0.05) and of 17 alpha-hydroxylase (Large White > Meishan, P < 0.01). Breed x treatment interactions were never detected. Finally, gelatinases, plasminogen activator, plasminogen activator inhibitor, tissue inhibitors of metalloproteases (TIMP-1 and TIMP-2) were visualized by direct or reverse zymography or western blotting. Whatever the stage relative to LH administration, follicular fluid from Large White gilts contained more TIMP-1, and TIMP-2 (P < 0.02 and P < 0.01, respectively). No breed effect was detected for the amounts of gelatinases and plasminogen activator inhibitor 1. However, for these parameters, a significant breed x time interaction was obvious, as the Meishan follicles had a greater response to hCG (P < 0.01). Since proteolysis plays a key role in the bioavailability of growth factors such as insulin-like growth factor 1, fibroblast growth factor and transforming growth factor beta, which have the ability to alter gonadotrophin-induced progesterone production in pigs, the differences observed in its control in the present study may explain, at least in part, the different patterns of luteinization observed in Meishan and Large White follicles. (+info)Opposing changes in 3alpha-hydroxysteroid dehydrogenase oxidative and reductive activities in rat leydig cells during pubertal development. (3/633)
The enzyme 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) has an important role in androgen metabolism, catalyzing the interconversion of dihydrotestosterone (DHT) and 5alpha-androstane-3alpha,17beta-diol (3alpha-DIOL). The net direction of this interconversion will affect the amount of biologically active ligand available for androgen receptor binding. We hypothesize that in Leydig cells, differential expression of 3alpha-HSD enzymes favoring one of the two directions is a mechanism by which DHT levels are controlled. In order to characterize 3alpha-HSD in rat Leydig cells, the following properties were analyzed: rates of oxidation (3alpha-DIOL to DHT) and reduction (DHT to 3alpha-DIOL) and preference for the cofactors NADP(H) and NAD(H) (i.e., the oxidized and reduced forms of both pyridine nucleotides) in Leydig cells isolated on Days 21, 35, and 90 postpartum. Levels of 3alpha-HSD protein were measured by immunoblotting using an antibody directed against the liver type of the enzyme. Levels of 3alpha-HSD protein and rates of reduction were highest on Day 21 and lowest on Day 90. The opposite was true for the rate of 3alpha-HSD oxidation, which was barely detectable on Day 21 and highest on Day 90 (59.08 +/- 6.35 pmol/min per 10(6) cells, mean +/- SE). Therefore, the level of 3alpha-HSD protein detectable by liver enzyme was consistent with reduction but not with oxidation. There was a clear partitioning of NADP(H)-dependent activity into the cytosolic fraction of Leydig cells, whereas on Days 35 and 90, Leydig cells also contained a microsomal NAD(H)-activated 3alpha-HSD. We conclude that 1) the cytosolic 3alpha-HSD in Leydig cells on Day 21 behaves as a unidirectional NADPH-dependent reductase; 2) by Day 35, a microsomal NAD(H)-dependent enzyme activity is present and may account for predominance of 3alpha-HSD oxidation over reduction and the resultant high capacity of Leydig cells on Day 90 to synthesize DHT from 3alpha-DIOL. (+info)Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI isoforms in the mouse testis during development. (4/633)
Six isoforms of the enzyme 3beta-hydroxysteroid dehydrogenase (3betaHSD) have been identified in the mouse, each the product of a distinct gene. Two of these isoforms (type I and type VI) are detectable in the adult testis but changes in their expression during development are unknown. In this study we have examined changes in testicular expression and localization of mRNA encoding the type I and type VI isoforms of 3betaHSD. Total 3betaHSD (type I plus type VI) mRNA was measured by reverse transcription-polymerase chain reaction and showed a peak of expression at day 5 after birth followed by a decline and then a further rise after day 10 that continued up to adulthood. When each isoform was measured individually it was clear that the type I isoform was expressed at all ages from embryonic day 13 to adulthood. In contrast, the type VI isoform was only expressed at significant levels during fetal life on embryonic day 13 and then not again until after day 10 postnatally. Expression of the type VI isoform mRNA increased markedly after day 10 so that by adulthood it was the predominant 3betaHSD isoform present in the testis. Closer examination of the timing of type VI expression showed that the isoform mRNA was first detectable at a significant level on day 11. In-situ hybridization confirmed that the type I isoform is the only one expressed in the fetal/neonatal animal and showed that expression was limited to the interstitial tissue. In the adult, both type I and type VI expression was within the interstitial tissue. The timing of 3betaHSD type VI mRNA expression suggests, strongly, that this isoform is expressed only by adult-type Leydig cells in the mouse testis and that this development starts shortly before day 11. The limited expression of the type VI isoform means that it will be a useful marker in studies of adult Leydig cell development. (+info)Molecular cloning and characterization of hemolymph 3-dehydroecdysone 3beta-reductase from the cotton leafworm, Spodoptera littoralis. A new member of the third superfamily of oxidoreductases. (5/633)
The primary product of the prothoracic glands of last instar larvae of Spodoptera littoralis is 3-dehydroecdysone (3DE). After secretion, 3DE is reduced to ecdysone by 3DE 3beta-reductase in the hemolymph. We have previously purified and characterized 3DE 3beta-reductase from the hemolymph of S. littoralis. In this study, cDNA clones encoding the enzyme were obtained by reverse transcription-polymerase chain reaction, employing primers based on the amino acid sequences, in conjunction with 5'- and 3'-rapid amplification of cDNA ends. Multiple polyadenylation signals and AT-rich elements were found in the 3'-untranslated region, suggesting that this region may have a role in regulation of expression of the gene. Conceptual translation and amino acid sequence analysis suggest that 3DE 3beta-reductase from S. littoralis is a new member of the third superfamily of oxidoreductases. Northern analysis shows that 3DE 3beta-reductase mRNA transcripts are widely distributed, but are differentially expressed, in some tissues. The developmental profile of the mRNA revealed that the gene encoding 3DE 3beta-reductase is only transcribed in the second half of the last larval instar and that this fluctuation in expression accounts for the change in the enzyme activity during the instar. Southern analysis indicates that the 3DE 3beta-reductase is encoded by a single gene, which probably contains at least one intron. (+info)An inborn error of bile acid synthesis (3beta-hydroxy-delta5-C27-steroid dehydrogenase deficiency) presenting as malabsorption leading to rickets. (6/633)
Deficiency of 3beta-hydroxy-delta5-C27-steroid dehydrogenase (3beta-HSDH), the enzyme that catalyses the second reaction in the principal pathway for the synthesis of bile acids, has been reported to present with prolonged neonatal jaundice with the biopsy features of neonatal hepatitis. It has also been shown to present between the ages of 4 and 46 months with jaundice, hepatosplenomegaly, and steatorrhoea (a clinical picture resembling progressive familial intrahepatic cholestasis). This paper reports two children with 3beta-HSDH deficiency who developed rickets during infancy and did not develop clinically evident liver disease until the age of 3 years. Bile acid replacement resulted in considerable clinical and biochemical improvement. The importance of thorough investigation of fat soluble vitamin deficiencies in infancy is emphasised. (+info)Dynamics of periovulatory steroidogenesis in the rhesus monkey follicle after ovarian stimulation. (7/633)
The temporal relationships and regulation of events in the primate follicle during the periovulatory interval are poorly understood. This study was designed to elucidate the dynamics of steroid synthesis in the macaque follicle during ovarian stimulation cycles in which serum/follicular fluid aspirates were collected at precise intervals before (0 h) and after (up to 36 h) administration of the ovulatory human chorionic gonadotrophin (HCG) bolus. Serum concentrations of progesterone increased (P < 0.05) within 30 min, and follicular fluid progesterone concentrations were elevated 180-fold within 12 h, of HCG injection, and remained elevated until the time of ovulation. In contrast, 17beta-oestradiol concentrations increased initially, but then declined (P < 0.05) by 36 h post-HCG. Acute incubation of granulosa cells with and without steroidogenic substrates demonstrated that: (i) 3beta-hydroxysteroid dehydrogenase and aromatase activities were present in equivalent amounts before and after HCG; whereas (ii) P450 side-chain cleavage activity increased (P < 0.05) within 12 h of HCG; and (iii) exogenous low-density lipoprotein and cholesterol were not utilized for steroidogenesis. This model should be useful for further studies on ovulation and luteinization in primates, and enable elucidation of the local actions of progesterone and other steroids at specific time points during the periovulatory interval. (+info)Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. (8/633)
Previous data have suggested that glucocorticoids (GCs) are involved in the differentiation of thymocytes into mature T cells. In this report we demonstrate that the mouse thymic epithelial cells (TEC) express the cytochrome P450 hydroxylases Cyp11A1, Cyp21, and Cyp11B1. These enzymes, in combination with 3beta-hydroxysteroid dehydrogenase (3betaHSD), convert cholesterol into corticosterone, the major GC in rodents. In addition, when TEC were cocultured with 'reporter cells' containing the glucocorticoid receptor (GR) and a GR-dependent reporter gene, a specific induction of reporter gene activity was observed. Induction of reporter gene activity was blocked when the TEC and reporter cells were incubated in the presence of the Cyp11B1 inhibitor metyrapone or the 3betaHSD inhibitor trilostane, as well as by the GR antagonist RU486. Coculturing of TEC with thymocytes induced apoptosis in the latter, which was partially blocked by the enzyme inhibitors and RU486. We conclude that TEC secrete a GC hormone activity and suggest a paracrine role for this in thymocyte development. (+info)NSDHL polyclonal antibody (A01) - (H00050814-A01) - Products - Abnova
Recombinant Human NSDHL protein (ab162360) | Abcam
The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome P450 enzyme in...
Preparation of highly purified 3α- and 3β-hydroxysteroid dehydrogenases from Pseudomonas sp<...
KEGG BRITE: KEGG Orthology (KO) - Mus musculus (mouse)
Characterization and functional analysis of the 5′-flanking region of the mouse 20α-hydroxysteroid dehydrogenase gene |...
Hydroxysteroid Dehydrogenase
RCSB PDB
- 1I5R: TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EM1745 COMPLEX Macromolecule Annotations Page
Role of HSD17B13 in the Liver Physiology and Pathophysiology
NSDHL gene: MedlinePlus Genetics
Trilostane/Vetoryl Information and Resources
Trilostane/Vetoryl Information and Resources
Pregnancy sub-cluster 85
HSDL1 Gene - GeneCards | HSDL1 Protein | HSDL1 Antibody
JCI -
11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects
Schlinger Lab Homepage
Structural and functional aspects of placental lactogens (PLs) and ovarian 20α-hydroxysteroid dehydrogenase (20α-HSD) in the...
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Effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane on luteal progesterone production in the dog
Prolactin increases 17beta-hydroxysteroid dehydrogenase activity in th by N Musto, A A. Hafiez et al.
Regulation of 3β‐Hydroxysteroid Dehydrogenase Activity by Human Chorionic Gonadotropin, Androgens, and Antiandrogens in...
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Hsd3b2 - 3 beta-hydroxysteroid dehydrogenase/Delta 5--|4-isomerase type 2 - Mus musculus (Mouse) - Hsd3b2 gene & protein
The genes encoding gonadal and nongonadal forms of 3 beta-hydroxyster by P A. Bain, M H. Meisler et al.
EC 1.1.1.62
EC 1.1.1.62
AKR1C1 - wikidoc
Cytochrome Pregnenolone & 3 Hydroxysteroid Dehydrogenase: Macaque Corpus Luteum - Richard Stouffer
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Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole
Sci. Pharm. | Free Full-Text | Preparation of Recombinant Human Hydroxysteroid Dehydrogenases and Study of their Inhibitors
AKR1C1 Pre-design Chimera RNAi - (H00001645-R01) - Products - Abnova
Genatlas sheet
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase...
EMBL: CP001022.PE374
Naringenin and some of its useful pharmakinetics - AnabolicMinds.com
Inactive hydroxysteroid dehydrogenase-like protein elisa and antibody
No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British women. -...
JoVE Author Search: Liu JK
hydroxysteroid 11-beta dehydrogenase 1 | 1.-.-.- Oxidoreductases | IUPHAR/BPS Guide to PHARMACOLOGY
trilostane | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
3-beta HSD2 / HSD3B2 antibody | acris-antibodies.com
Anti-hydroxysteroid (17-beta) dehydrogenase 4抗体(ab97971)
Fishing Map
3 beta hydroxysteroid dehydrogenase deficiency (Symptoms, signs, causes, treatments & definition) - Medigest
5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. -...
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OriGene - AKR1C3 (NM 003739) cDNA Clone
11β-hydroxysteroid dehydrogenase type-II activity is affected by grapefruit juice and intense muscular work
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- dihydrodiol dehydrogenase
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Sequence Similarity
- 1J96: Human 3alpha-HSD type 3 in Ternary Complex with NADP and Testosterone Sequence Similarity...
Info required on 3-beta-hydroxy steroid dehydrogenase
3-beta-hydroxysteroid dehydrogenase deficiency: MedlinePlus Genetics
... hydroxysteroid dehydrogenase (HSD) deficiency is an inherited disorder that affects hormone-producing glands including the ... Pan Y, Zhong S, Hu RM, Gong W. Mutation of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) at the 3-untranslated region is ... A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase ( ... Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and ...
3-Beta-Hydroxysteroid Dehydrogenase Deficiency Medication: Glucocorticoids, Mineralocorticoids
3-beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare genetic disorder of steroid biosynthesis that results in ... decreased production of all 3 groups of adrenal steroids, which include mineralocorticoids, glucocorticoids, and sex steroids. ... 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. J Clin Endocrinol Metab. 2008 Apr. 93 ... 3beta-Hydroxysteroid dehydrogenase in human aorta. Endocr J. 2005 Feb. 52(1):111-5. [QxMD MEDLINE Link]. ...
3-Hydroxysteroid dehydrogenase - Wikipedia
3-Beta-Hydroxysteroid Dehydrogenase Deficiency Medication: Glucocorticoids, Mineralocorticoids
3-beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare genetic disorder of steroid biosynthesis that results in ... decreased production of all 3 groups of adrenal steroids, which include mineralocorticoids, glucocorticoids, and sex steroids. ... 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. J Clin Endocrinol Metab. 2008 Apr. 93 ... 3beta-Hydroxysteroid dehydrogenase in human aorta. Endocr J. 2005 Feb. 52(1):111-5. [QxMD MEDLINE Link]. ...
3α-Hydroxysteroid Dehydrogenase, recombinant from bacteria (r3 α-HSDH) - OYC Americas
Polycystic Ovarian Syndrome Differential Diagnoses
Table 2 - Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections -...
NADH-dependent dehydrogenase. Putative functions. 26. NA. nmrA. Putative nmrA negative transcriptional regulator family protein ... 3-β hydroxysteroid dehydrogenase/isomerase. Steroid metabolism. 17. (26). group_273. Recombinase/resolvase. Mobile genetic ... Volume 27, Number 3-March 2021 Research. Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing ...
EC 1.1.1.53 - 3\xCE\xB1(or 20\xCE\xB2)-hydroxysteroid dehydrogenase
... hydroxysteroid:NAD+ oxidoreductase also known as 3\xCE\xB1(or 20\xCE\xB2)-hydroxysteroid dehydrogenase ... hydroxysteroid dehydrogenase:. *1hdc: Mechanism of Inhibition of 3alpha,20beta-hydroxysteroid Dehydrogenase by a Licorice- ... Hydroxysteroid Dehydrogenase and Possible Roles of The Residues Conserved in Short-chain Dehydrogenases ... 1n5d: Crystal Structure of Porcine Testicular Carbonyl Reductase/ 20beta-hydroxysteroid Dehydrogenase. *1nff: Crystal Structure ...
3α‐Hydroxysteroid dehydrogenase | DC Fine Chemicals
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Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas...
The specific crossreaction of antibodies directed against mammalian liver type I 11 beta-hydroxysteroid dehydrogenase (11 beta- ... No dihydrodiol dehydrogenase activity towards trans- or cis-benzene-dihydrodiols could be detected, thus distinguishing it from ... It belongs to the protein superfamily of short-chain dehydrogenases/reductases (SDR) as established by N-terminal sequence ... Along with the 3 alpha-hydroxysteroid dehydrogenase and 3-oxo-reductase activities towards a variety of cis or trans fused A/B ...
SCOPe 2.08: Protein: 11-beta-hydroxysteroid dehydrogenase 1
Timeline for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases: *Protein 11-beta- ... Lineage for Protein: 11-beta-hydroxysteroid dehydrogenase 1. *Root: SCOPe 2.08 *. Class c: Alpha and beta proteins (a/b) [51349 ... Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.07. ... More info for Protein 11-beta-hydroxysteroid dehydrogenase 1 from c.2.1.2: Tyrosine-dependent oxidoreductases. ...
Genetic Testing - Beta-hydroxysteroid dehydrogenase deficiency 3 -... (3-hydroxysteroid dehydrogenase deficiency beta) - Gen ...
Beta-hydroxysteroid dehydrogenase deficiency of 3-beta-hidroxiesteriode, (3-hydroxysteroid dehydrogenase deficiency beta) - Gen ... Genetic Testing - Beta-hydroxysteroid dehydrogenase deficiency 3 -... (3-hydroxysteroid dehydrogenase deficiency beta) - Gen ... People with 3?-HSD deficiency lack many of the hormones that are synthesized in these glands. This disease is one of a group of ... In general, women with 3?-HSD deficiency are infertile. This process is due to mutations in the gene HSD3B2, located on the ...
Congenital Adrenal Hyperplasia - 1st Edition
SCOPe 2.05: Structural Classification of Proteins - extended
Compound: 3alpha-hydroxysteroid dehydrogenase type 3. Species: Homo sapiens [TaxId:9606]. Database cross-references and ... Compound: 3alpha-hydroxysteroid dehydrogenase type 3. Species: Homo sapiens [TaxId:9606]. Database cross-references and ... Description: Human 3alpha-HSD type 3 in Ternary Complex with NADP and Testosterone. Class: oxidoreductase. Keywords: Aldo-keto ...
Hyperkalemia: Practice Essentials, Background, Pathophysiology
Type I pseudohypoaldosteronism (PHAI) can be caused by an inactivating mutation of 1 of 3 encoding subunits of the epithelial ... Maintenance of serum potassium with sodium zirconium cyclosilicate (ZS-9) in heart failure patients: results from a phase 3 ... Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature. 2012 Jan 22. 482(7383):98-102 ... 11-Beta hydroxylase deficiency, 3-beta hydroxysteroid dehydrogenase deficiency, and 17 alpha-hydroxylase/17,20-lyase deficiency ...
Congenital Adrenal Hyperplasia
Professor Yuqin Wang - Swansea University
Dickson, A., Yutuc, E., Thornton, C., Dunford, J., Oppermann, U., Wang, Y., & Griffiths, W. (n.d.) HSD3B1 is an Oxysterol 3β- ... Hydroxysteroid Dehydrogenase in Human Placenta. bioRxiv. https://doi.org/10.1101/2022.04.01.486576, SU Repository: https:// ... Dickson, A., Yutuc, E., Thornton, C., Dunford, J., Oppermann, U., Wang, Y., & Griffiths, W. (n.d.) HSD3B1 is an Oxysterol 3β- ... Hydroxysteroid Dehydrogenase in Human Placenta. bioRxiv. https://doi.org/10.1101/2022.04.01.486576, SU Repository: https:// ...
Human Metabolome Database: HMDB0012458 (7alpha-Hydroxy-3-oxo-4-cholestenoate) Protein Associations
AKR1C1 purified MaxPab mouse polyclonal antibody (B01P) - (H00001645-B01P) - Products - Abnova
20 alpha-hydroxysteroid dehydrogenase,OTTHUMP00000018992,aldo-keto reductase C,aldo-keto reductase family 1, member C1, ... dihydrodiol dehydrogenase isoform DD1,hepatic dihydrodiol dehydrogenase,trans- ... High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: ... aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) ...
2-deoxyecdysone | Semantic Scholar
Sebaceous Hyperplasia: Background, Pathophysiology, Etiology
... and 17-beta-hydroxysteroid dehydrogenase type II. These enzymes metabolize relatively weak circulating androgens, such as ... 3] scrotum, [4] foreskin, [5] shaft of penis, [6] and vulva. [7, 8, 9] Rarely reported variants have included a giant form, [10 ... Sebocytes contain androgen-metabolizing enzymes, including 5-alpha-reductase type I, 3-beta-hydroxysteroid dehydrogenase, ...
Frontiers | Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts
Oxidation and epimerization are catalyzed by hydroxysteroid dehydrogenase. Epimerization is a reversible stereochemical change ... 3. Fontana J, Trnka J, Mada P, Ivák P, Lavríková P, Nováková L, et al. Functions of Cells and Human Body. Prague: Karlovy ... 3). (B) Bile acids can be conjugated with either glycine or taurine. In this example, cholic acid becomes either taurocholic ... Growth of S. enterica in the presence of DOC is also associated with a decrease in 3-3 crosslinks between the sugar components ...
Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen | BMC Genomics |...
Genes for hydroxysteroid dehydrogenases (HSDs) 3β-HSD and 11β-HSD and cytochrome P450 aromatase A-isoform (CYP19A) were not ... hydroxysteroid dehydrogenases (HSDs) 3β-HSD [85] and 11β-HSD [86], inhibin (INHB) and cytochrome P450 aromatase A-isoform ( ... hydroxysteroid dehydrogenases including 3β-HSD and 11β-HSD. ... Figure 3. Comparison of overall gene regulation. (A) 5 ng EE2/L ... The Q-PCR conditions were 95°C for 3 min and 40 cycles at 95°C for 15 sec and 60°C for 1 min in an iCycler Thermal Cycler (Bio- ...
Congenital adrenal hyperplasia | T-Vox
HSD is hydroxysteroid dehydrogenase.. *P450scc is cytochrome P450 side chain cleavage enzyme. ... The corona was 3 cm long and 8 cm in circumference. There was an ample prepuce. There was a first grade hypospadias… There were ... 3β-HSD CAH. 3βHSD II. 1p13. pregnenolone→17OH-pregnenolone→DHEA→. progesterone. 17OH-progesterone. androstenedione. ... Congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency. *Congenital adrenal hyperplasia due to 11β- ...
Pitfalls in hormonal diagnosis of 17-beta hydroxysteroid dehydrogenase III deficiency - Fingerprint
- Oregon Health &...
PDB-4fam: Crystal structure of human 17beta-hydroxysteroid dehydrogenase ty... - Yorodumi
3alpha(or 20beta)-hydroxysteroid dehydrogenase / testosterone dehydrogenase (NAD+) activity / androsterone dehydrogenase ... hydroxysteroid dehydrogenase / 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity / 3alpha(17beta)-hydroxysteroid ... 17-beta-hydroxysteroid dehydrogenase (NAD+) activity / NAD-retinol dehydrogenase activity / aldo-keto reductase (NADP) activity ... 3beta(or 20alpha)-hydroxysteroid dehydrogenase .... prostaglandin D2 11-ketoreductase activity / cellular response to ...