An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. It was formerly characterized as EC 1.13.1.6.
An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by catalyzing the HYDROXYLATION of KYNURENINE to 3-hydroxykynurenine. It was formerly characterized as EC 1.14.1.2 and EC 1.99.1.5.
Benzoic acid or benzoic acid esters substituted with one or more nitro groups.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27.
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC 1.13.11.3.
An enzyme that catalyzes the conversion of L-CYSTEINE to 3-sulfinoalanine (3-sulfino-L-alanine) in the CYSTEINE metabolism and TAURINE and hypotaurine metabolic pathways.
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.
A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.
A gram-negative, facultatively chemoautotrophic bacterium, formerly called Wautersia eutropha, found in water and soil.
A genus of gram-negative, aerobic, rod-shaped bacteria, in the family BURKHOLDERIACEAE, that are mobile by means of peritrichous FLAGELLA. The genus was formerly called Wautersia and species in this genus were formerly in the genus RALSTONIA.
A species of Ralstonia previously classed in the genera PSEUDOMONAS and BURKHOLDERIA. It is an important plant pathogen.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
The total process by which organisms produce offspring. (Stedman, 25th ed)
The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
The number of offspring produced at one birth by a viviparous animal.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.
A group of seed storage proteins restricted to the POACEAE family. They are rich in GLUTAMINE and PROLINE.
A plant species of the family POACEAE that is widely cultivated for its edible seeds.
The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.
The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The systematic study of the complete DNA sequences (GENOME) of organisms.
A DNA-directed RNA polymerase found in BACTERIA. It is a holoenzyme that consists of multiple subunits including sigma factor 54.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
A protrusion of abdominal structures through the retaining ABDOMINAL WALL. It involves two parts: an opening in the abdominal wall, and a hernia sac consisting of PERITONEUM and abdominal contents. Abdominal hernias include groin hernia (HERNIA, FEMORAL; HERNIA, INGUINAL) and VENTRAL HERNIA.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA.
3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction ... DECKER RH, KANG HH, LEACH FR, HENDERSON LM (1961). "Purification and properties of 3-hydroxyanthranilic acid oxidase". J. Biol ... The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing). Other names in ... 2-amino-3-carboxymuconate semialdehyde Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O2, whereas its ...
... dioxygenases MeSH D08.811.682.690.416.277 - catechol 1,2-dioxygenase MeSH D08.811.682.690.416.305 - catechol 2,3-dioxygenase ... 2-oxoglutarate 5-dioxygenase MeSH D08.811.682.690.708.673 - procollagen-proline dioxygenase MeSH D08.811.682.690.708.715 - ... MeSH D08.811.682.690.416.319 - cysteine dioxygenase MeSH D08.811.682.690.416.326 - homogentisate 1,2-dioxygenase MeSH D08.811. ... gamma-butyrobetaine dioxygenase MeSH D08.811.682.690.708.410 - heme oxygenase (decyclizing) MeSH D08.811.682.690.708.410.500 - ...
α-Ketoisocaproate dioxygenase. *Leucine 2,3-aminomutase. *Methylcrotonyl-CoA carboxylase. *Methylglutaconyl-CoA hydratase ... 44 (3): e69. doi:10.1136/jmg.2006.043448. PMC 2598024. PMID 17361008.. *^ Kure S, Mandel H, Rolland MO, Sakata Y (April 1998 ... 45 (3): 137-49. doi:10.1007/bf00230082. PMID 6750353.. *^ Yoshida T, Kikuchi G, Tada K, Narisawa K, Arakawa T (May 1969). " ... doi:10.1016/0003-9861(79)90267-4. PMID 389161.. *^ Pares S, Cohen-Addad C, Sicker L, Neuburger M, Douce R (May 1994). "X-ray ...
α-Ketoisocaproate dioxygenase. *Leucine 2,3-aminomutase. *Methylcrotonyl-CoA carboxylase. *Methylglutaconyl-CoA hydratase ... 33 (3): 675-81. doi:10.1021/bi00169a007. PMID 7904828.. *^ a b c d Stryer L, Berg JM, Tymoczko JL (2007). Biochemistry (6th ed ... 61 (4): 383-8. doi:10.4103/0028-3886.117615. PMID 24005729.. *^ a b Willard-Mack CL, Koehler RC, Hirata T, et al. (March 1996 ... 8 (4): 52. doi:10.3390/life8040052. PMC 6316151. PMID 30373240.. *^ Merrick MJ, Edwards RA (December 1995). "Nitrogen control ...
α-Ketoisocaproate dioxygenase. *Leucine 2,3-aminomutase. *Methylcrotonyl-CoA carboxylase. *Methylglutaconyl-CoA hydratase ... See Template:Leucine metabolism in humans - this diagram does not include the pathway for β-leucine synthesis via leucine 2,3- ... Lima S, Kumar S, Gawandi V, Momany C, Phillips RS (January 2009). "Crystal structure of the Homo sapiens kynureninase-3- ... Inada J, Okuno E, Kimura M, Kido R (1984). "Intracellular localization and characterization of 3-hydroxykynureninase in human ...
α-Ketoisocaproate dioxygenase. *Leucine 2,3-aminomutase. *Methylcrotonyl-CoA carboxylase. *Methylglutaconyl-CoA hydratase ... 128 (3): 489-94. PMC 1204522. PMID 1874410.. *^ Lehninger, Albert L.; Nelson, David L.; Cox, Michael M. (2000). Principles of ... 3-Phosphoglycerates: serine, glycine, cysteine[edit]. Serine[edit]. Serine is the first amino acid in this family to be ... 1 (4): 495-505. doi:10.1016/0020-711X(70)90065-0.. *^ Pilzer LI (December 1963). "The Pathway and Control of Serine ...
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14). 1.14.11: 2-oxoglutarate. *Prolyl hydroxylase *HIF ... 127 (4): 751-61. doi:10.1038/sj.jid.5700683. PMID 17218941.. *^ Chang TS (Jun 2009). "An updated review of tyrosinase ... 16 (4): 327-30. PMID 546241.. *^ Ando H, Kondoh H, Ichihashi M, Hearing VJ (Apr 2007). "Approaches to identify inhibitors of ... 17 (4): 207-18. doi:10.1080/14756360210000010923. PMID 12530473.. *^ Sollai F, Zucca P, Sanjust E, Steri D, Rescigno A ( ...
α-Ketoisocaproate dioxygenase. *Leucine 2,3-aminomutase. *Methylcrotonyl-CoA carboxylase. *Methylglutaconyl-CoA hydratase ... 31 (3): 171-5. doi:10.1080/07435800500371706. PMID 16392619.. *^ Johannsen S, Berberich C, Metterlein T, Roth C, Reiners K, ... 978-0-7817-4611-3. . OCLC 56446391.. *^ Johnsen SH, Lilleng H, Wilsgaard T, Bekkelund SI (January 2011). "Creatine kinase ... 1991 [4]). The atomic structure of cytosolic brain-type BB-CK was solved at 1.4 ! Angstroms in 1999. (Eder et al. 1999 [5]). ...
... (/ˌɛlˈdoʊpə/), also known as levodopa (/ˌlɛvoʊˈdoʊpə/) or L-3,4-dihydroxyphenylalanine is an amino acid that is made and ... 16 (3): 106-112. doi:10.1021/ar00087a006.. *^ "Synthetic scheme for total synthesis of DOPA, L- (Monsanto)". UW Madison, ... 81 (3-4): 1-21. doi:10.1080/00218460590944602.. *^ "Study Reveals Details Of Mussels' Tenacious Bonds". Science Daily. Aug 16, ... 2 (3): 126-133.. *^ Waite, J. Herbert; Andersen, Niels Holten; et al. (2005). "Mussel Adhesion: Finding the Tricks Worth ...
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously ... 3-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST. 286. Proteomic databases. PaxDb, a database of protein abundance averages ... 3. Helixi. 141 - 149. Combined sources. Manual assertion inferred from combination of experimental and computational evidencei ... 3. Helixi. 183 - 188. Combined sources. Manual assertion inferred from combination of experimental and computational evidencei ...
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously ... 3-HAOUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic annotation system ... Annotation score:3 out of 5. ,p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB ... 3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation. ,p>Manual validated information which has been generated by the ...
3-Hydroxyanthranilate 3,4-dioxygenase (3HAO) is a non-heme iron dependent enzyme. It catalyses the cleavage of the benzene ring ... 3-Ohaa), an intermediate in the kynurenine pathway, and therefore represents a potential target in treating numerous disorders ... a Faculty of Medicine, J. Huttlera 4, HR-31000 Osijek, Croatia b Ruđer Bošković Institute, Bijenička 54, HR-10000 Zagreb, ... 3-Hydroxyanthranilate 3,4-dioxygenase (3HAO) is a non-heme iron dependent enzyme. It catalyses the cleavage of the benzene ring ...
3hydroxyanthranilic acid dioxygenase; 3-HAO; 3-hydroxyanthranilate 3;3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid ... Recombinant Human 3-hydroxyanthranilate 3,4-dioxygenase, His-tagged. Download Datasheet See All HAAO Products. Bring this ... Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing ... dioxygenase;3HAO_HUMAN; 4-dioxygenase; haao; HAD; HAO; HAD; 3-hydroxyanthranilateoxygenase; 3-hydroxyanthranilic acid ...
The Crystal Structure of 3-Hydroxyanthranilate 3,4- Dioxygenase From Saccharomyces Cerevisiae ... Dioxygenase From Saccharomyces Cerevisiae (pdb code 1zvf). This binding sites where shown with 5.0 Angstroms radius around ... Nickel binding site 3 out of 4 in 1zvf. Click to enlarge. Click to enlarge. Mono- and Stereo- picture of 5.0 Angstrom ... Nickel binding site 4 out of 4 in 1zvf. Click to enlarge. Click to enlarge. Mono- and Stereo- picture of 5.0 Angstrom ...
Crystal Structure of 3-Hydroxyanthranilate-3,4-Dioxygenase From Ralstonia Metallidurans Complexed With 3-Hydroxyanthranilic ... The binding sites of Iron atom in the structure of Crystal Structure of 3-Hydroxyanthranilate-3,4-Dioxygenase From Ralstonia ... Iron in the structure of Crystal Structure of 3-Hydroxyanthranilate-3,4-Dioxygenase From Ralstonia Metallidurans Complexed With ... Metallidurans Complexed With 3-Hydroxyanthranilic Acid (pdb code 1yfy). This binding sites where shown with 5.0 Angstroms ...
To examine the relationship between this enzyme and other dioxygenases, 2-aminophenol 1,6-dioxygenase has been purified by ... 2-aminophenol 1,6-dioxygenase: a novel aromatic ring cleavage enzyme purified from Pseudomonas pseudoalcaligenes JS45.. U ... The substrate range and the subunit structure are unique among those of the known ring cleavage dioxygenases. ... 2-aminophenol 1,6-dioxygenase: a novel aromatic ring cleavage enzyme purified from Pseudomonas pseudoalcaligenes JS45. ...
Keywords: Complex structure, Dioxygenase, Mutant I142P, OXIDOREDUCTASE, 4-Cl-3-HAA. Deposited on 2018-04-19, released 2018-06- ... Compound: 3-hydroxyanthranilate 3,4-dioxygenase. Species: Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 ... Description: Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase I142P from Cupriavidus metallidurans in complex with 4- ...
Compound: 3-hydroxyanthranilate-3,4-dioxygenase. Species: Cupriavidus metallidurans [TaxId:119219]. Database cross-references ... Description: Crystal structure of 3-hydroxyanthranilate-3,4-dioxygenase from Ralstonia metallidurans complexed with 3- ...
... 18 sulfur dioxygenase. EC 1.13.11.19 cysteamine dioxygenase. EC 1.13.11.20 cysteine dioxygenase. EC 1.13.11.21 now ... 5-dioxygenase. EC 1.13.11.9 2,5-dihydroxypyridine 5,6-dioxygenase. EC 1.13.11.10 7,8-dihydroxykynurenate 8,8a-dioxygenase. EC ... Other name(s): 10R-DOX; (10R)-dioxygenase; 10R-dioxygenase. Systematic name: linoleate:oxygen (10R)-oxidoreductase. Comments: ... EC 1.13.11.87 endo-cleaving rubber dioxygenase. EC 1.13.11.1. Accepted name: catechol 1,2-dioxygenase. Reaction: catechol + O2 ...
Table 4 Significant SNPs for age at first calving with chromosome number, percentage of phenotypic variance explained by the ... 4.. Shiotsuki L, Silva 2nd JAV, Tonhati H, Albuquerque LG. Genetic associations of sexual precocity with growth traits and ... 3.. Formigoni IB, Ferraz JBS, Silva JAIIV, Eler JP, Brumatti RC. Valores econômicos para habilidade de permanência e ... Table 3 Significant SNPs for heifer rebreeding with chromosome number, percentage of phenotypic variance explained by the SNP ...
2. 3-hydroxyanthranilate 3,4-dioxygenase. General function:. Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity. ... 2-Amino-3-carboxymuconic acid semialdehyde. Description. 2-amino-3-carboxymuconic acid semialdehyde is an intermediate ... I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID. J Biol Chem. 1965 Feb;240:733-9. [PubMed:14275129 ] ... 2-Amino-3-carboxymuconic semialdehyde is enzymatically converted to 2-aminomuconate via 2-aminomuconic semialdehyde. (PMID: ...
3. Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683-92. [PMC free article] [PubMed] ... 4. Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet. 2007;8:286-98. [PubMed] ... 4. Methylation of HAAO CpG island and clinicopathologic covariates analyses in primary endometrial carcinomas. (A) Methylation ... 2). The detailed methylation level of each CpG unit (1-4 CpG sites per unit) was showed in Supplementary Fig. S1. These results ...
DNA methylation in the promoter region of a gene is associated with a loss of that genes expression and plays an important role in gene silencing. The inactivation of tumor-suppressor genes by aberrant methylation in the promoter region is well recognized in carcinogenesis. However, there has been little study in this area when it comes to genome-wide profiling of the promoter methylation. Here, we developed a genome-wide profiling method called Microarray-based Integrated Analysis of Methylation by Isoschizomers to analyse the DNA methylation of promoter regions of 8091 human genes. With this method, resistance to both the methylation-sensitive restriction enzyme HpaII and the methylation-insensitive isoschizomer MspI was compared between samples by using a microarray with promoter regions of the 8091 genes. The reliability of the difference in HpaII resistance was judged using the difference in MspI resistance. We demonstrated the utility of this method by finding epigenetic mutations in ...
3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction ... DECKER RH, KANG HH, LEACH FR, HENDERSON LM (1961). "Purification and properties of 3-hydroxyanthranilic acid oxidase". J. Biol ... The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing). Other names in ... 2-amino-3-carboxymuconate semialdehyde Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O2, whereas its ...
IgG3 + B cells are associated with the development of multiple sclerosis. Marsh-Wakefield, F., Ashhurst, T., Trend, S., McGuire ... Hart, P. H., Norval, M. & Reeve, V. E., 2017, In : Photochemical and Photobiological Sciences. 16, 3, p. 281-282 2 p.. Research ... 3, p. 473-486 14 p.. Research output: Contribution to journal › Article ... 3, p. 221-230 10 p.. Research output: Contribution to journal › Article ...
3-Hydroxyanthranilate 34-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases ... HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is ...
4-1BBL, Human recombinant Supplier: RayBiotech • Format: Lyophilized from 5 mM Tris,pH 8.0 + 75 mM NaCl. ... 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1, Human Recombinant Supplier: RayBiotech • Format: Sterile Filtered clear solution. ... 3-Ketodihydrosphingosine Reductase, Human Recombinant Supplier: RayBiotech • Format: The ,KDSR is supplied as a sterile ... 4-1BB Ligand, Human Recombinant Supplier: RayBiotech • Format: Sterile Filtered White lyophilized (freeze-dried) powder. ...
Copyright (c) 2004-2017 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California. All rights reserved ...
It expands the number of oat ESTs 3-fold, and constitutes the first comprehensive transcriptome study in oat. This resource ... Ishihara A, Miyagawa H, Matsukawa T, Ueno T, Mayama S, Iwamura H: Induction of hydroxyanthranilate hydroxycinnamoyl transferase ... TXT 3 MB). Additional file 9: File containing the dn OST gene-derived SSR markers with the potential to be used in oat breeding ... Figure 3. Abundance and distribution of the dn OST transcript assembly compared to the Brachypodium genome. SSR-bearing oat ...
Identification of a Chemoreceptor for C2 and C3 Carboxylic Acids. Vanina García, Jose-Antonio Reyes-Darias, David Martín-Mora, ... FIG 3 Mutation of the mcpP gene does not alter motility but reduces chemotaxis to pyruvate and propionate. (A) Swim plate ... The NbaY LBD was dialyzed into 5 mM Tris-HCl-5 mM PIPES-5 mM MES (pH 8.0), adjusted to 4 μM, loaded into a 3-mm quartz cuvette ... 4). As mentioned above, the McpS chemoreceptor of P. putida KT2440 mediates chemotaxis toward Krebs cycle organic acids and, ...
Crystallization and X-ray Diffraction Analysis to 1.5 A Resolution of Rat Cysteine Dioxygenase, a Mononuclear Iron Enzyme ... Pereira R, Cerione RA; "A Switch 3 Point Mutation in the Alpha Subunit of Transducin Yields a Unique Dominant-negative ... Gump JC, Peiris SM; "Isothermal Equations of State of Beta octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine at High ... "4-Benzyl and 4-Benzoyl-3-dimethylaminopyridin-2(1H)-ones: In vitro evaluation of new C-3-Amino-subsituted and C-5,6-Alkyl- ...
Rabbit Anti-Human/Mouse/Rat Small Ubiquitin-related Modifier 2 and 3 (SMT3B, SMT3H2, SMT3 homolog 2). 100 µg. PK-AB718-5755. ... Rabbit Anti-Human/Mouse/Rat Small Ubiquitin-related Modifier 3 (SMT3A, SMT3H1, SMT3 homolog 1. 100 µg. PK-AB718-5757. ... Rabbit Anti-Human/Mouse/Rat ZBED3 (Zinc Finger BED-type Domain Containing 3; NT). 100 µg. PK-AB718-5123. ... Rabbit Anti-Human/Mouse Zinc finger MYM-type protein 3 (ZNF261, ZNF198L2, XFIM, MYM). 100 µg. PK-AB718-6137. ...
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2). 0.093. ... SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. 0.727. ... signal transducer and activator of transcription 3 (acute-phase response factor). 0.923. ...
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide). 0.035 ... ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3. 0.011. ... protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4. 0.017. ... hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. 0.078. ...
3-Hydroxyanthranilate 3,4-dioxygenase Current Synonym true false 32272011 3-Hydroxyanthranilate oxygenase Current Synonym true ... 3-hydroxyanthranilate oxygenase Current Synonym true false 3721341019 3-hydroxyanthranilate 3,4-dioxygenase Current Synonym ... 3-hydroxyanthranilate 3,4-dioxygenase (substance). Code System Preferred Concept Name. 3-hydroxyanthranilate 3,4-dioxygenase ( ...
The results obtained demonstrate that periodically repeated tossing-up stimuli caused increased expression of 3-HAO and c-fos ... Publications] Nakagawa,Y.et al.: Increased expression of 3-hvdroxvanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone ... Publications] Nakagawa,Y.et al.: Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsyprone ... Publications] Nakagawa, Y.et al.: Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy- ...
... dioxygenases MeSH D08.811.682.690.416.277 - catechol 1,2-dioxygenase MeSH D08.811.682.690.416.305 - catechol 2,3-dioxygenase ... 2-oxoglutarate 5-dioxygenase MeSH D08.811.682.690.708.673 - procollagen-proline dioxygenase MeSH D08.811.682.690.708.715 - ... MeSH D08.811.682.690.416.319 - cysteine dioxygenase MeSH D08.811.682.690.416.326 - homogentisate 1,2-dioxygenase MeSH D08.811. ... gamma-butyrobetaine dioxygenase MeSH D08.811.682.690.708.410 - heme oxygenase (decyclizing) MeSH D08.811.682.690.708.410.500 - ...
Figure 4. Significantly regulated proteins categorized by GO terms. (A) Biological process, (B) Cellular components, (C) ... Figure 3. Immunohistochemistry of proteins regulated in hepatocellular carcinoma of EGF transgenic mice. Shown are images of (A ... Additional file 4: Table S4.. Comparison of disease regulated proteins in mouse and human HCC. Data were taken from The Human ... 3.. Melle C, Ernst G, Scheibner O, Kaufmann R, Schimmel B, Bleul A, et al. Identification of specific protein markers in ...
Investigation Of A Novel Mammalian Thiol Dioxygenase Structure: Human Cysteamine Dioxygenase, Tseng Xiong and Tseng Xiong ... Interactions of Metals and Radicals: A Biochemical Perspective in Tryptophan Dioxygenase, Kednerlin Dornevil ... Exploring HIV Integrase 3-processing Using Designed DNA Substrates and Structural Study of HIV DNA Hairpins, Qiushi Li ... Understanding Integrase-DNA Interactions in Retroviruses Through 3-processing, Zachary E. Ferris and Markus W. Germann ...
  • Indoleamine-2,3- dioxygenase activity was increased in the brain, kidney, lung, spleen, and duodenum while hepatic L-tryptophan-2,3-dioxygenase activity was reduced, data consistent with in vitro L-kynurenine formation from L-tryptophan. (fujita-hu.ac.jp)
  • In the Kyn pathway, IDO1/IDO2 and tryptophan-2,3-dioxygenase (TDO) catalyze the first and rate-limiting step of Trp degradation that gives rise to N -formylkynurenine. (frontiersin.org)
  • We found a reduction in the enzymatic conversion of tryptophan to kynurenine, determined using the kynurenine:tryptophan ratio, and reduced messenger RNA expression of the enzymes indoleamine-2,3-dioxygenase 1 and 2 and tryptophan-2,3-dioxygenase in depressed individuals irrespective of the cause of death. (jpn.ca)
  • 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction 3-hydroxyanthranilate + O2 ⇌ {\displaystyle \rightleftharpoons } 2-amino-3-carboxymuconate semialdehyde Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O2, whereas its product is 2-amino-3-carboxymuconate semialdehyde. (wikipedia.org)
  • HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. (bio-rad.com)
  • 3-Hydroxyanthranilate 3,4-dioxygenase ( 3HAO ) is a non-heme iron dependent enzyme. (rsc.org)
  • The stability and behaviour of the enzyme in nearly physiological conditions, studied by the empirical molecular modelling methods enabled us to determine the influence of several, for the enzyme activity relevant, point mutations (Arg43Ala, Arg95Ala and Glu105Ala) on the protein structure, particularly on the active site architecture and the metal ion environment, as well as on the substrate, 3-Ohaa, binding. (rsc.org)
  • Besides, the water population of the active site, and the protein flexibility as well as the amino acid residues interaction networks relevant for the enzyme activity were determined for the 3-Ohaa complexes with the native and mutated enzyme variants. (rsc.org)
  • 2-aminophenol 1,6-dioxygenase: a novel aromatic ring cleavage enzyme purified from Pseudomonas pseudoalcaligenes JS45. (asm.org)
  • To examine the relationship between this enzyme and other dioxygenases, 2-aminophenol 1,6-dioxygenase has been purified by ethanol precipitation, gel filtration, and ion exchange chromatography. (asm.org)
  • The enzyme catalyzed the oxidation of catechol, 6-amino-m-cresol, 2-amino-m-cresol, and 2-amino-4-chlorophenol. (asm.org)
  • The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing). (wikipedia.org)
  • An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. (bvsalud.org)
  • are attracted by quinolinic acid which is synthesized by means of the kynurenine pathway by the enzyme 3-hydroxyanthranilate 3,4-dioxygenase (HAD). (davincieuropeanbiobank.org)
  • Inhibitors targeting the indoleamine-2,3-dioxygenase 1 enzyme (IDO1) represent one of the most potent therapeutic opportunities to inhibit tumor growth. (frontiersin.org)
  • Indolamine-2,3-dioxygenase 1 is a cytosolic enzyme with a heme (Fe 2+ ) prosthetic group that catalyzes the first and rate-limiting step of tryptophan (Trp) catabolism (Figure 1 A). IDO1 converts the essential amino acid Trp to kynurenine (Kyn) by cleaving the 2,3-double bond of the indole ring while a molecular oxygen (O 2 ) merges into the unsealed molecule. (frontiersin.org)
  • Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). (springer.com)
  • We also thank Erin Stachowski for excellent technical assistance with the measurement of 3-HK levels and KP enzyme activities in human brain tissues. (springer.com)
  • Increased activity of indoleamine-2,3-dioxygenase,the first enzyme of the kynurenine pathway, was indicated in the macaques with SAIDS by reduced serum Gtryptophan and elevated serum Gkynurenine concentrations. (docme.ru)
  • In endotoxin-treated mice, the activity of indoleamine-2,3-dioxygenase(IDO), the first enzyme of the kynurenine pathway that synthesizes QUIN, is increased in several extrahepatic tissues, plasma L-kynurenine (L-KYN) is elevated [4], and QUIN, 3-hydroxykynurenine L-TRP and 5-hydroxyindoleacetic acid (5-HIAA) concentrations are increased in cerebral cortex [5, 61. (docme.ru)
  • McCulloch, K. M. , Mukherjee, T. , Begley, T. P. , and Ealick, S. E. (2009) Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications . (cornell.edu)
  • Immunotherapy with these DCs promoted an immune response to apoB100 that favoured the accumulation of Treg cells in atherosclerotic plaques, increased vascular expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1), and ameliorated atherosclerosis. (wesrch.com)
  • Methylmalonyl CoA epimerase ( EC 5.1.99.1 , methylmalonyl-CoA racemase , methylmalonyl coenzyme A racemase , DL-methylmalonyl-CoA racemase , 2-methyl-3-oxopropanoyl-CoA 2-epimerase [incorrect] ) is an enzyme involved in fatty acid catabolism that is encoded in human by the "MCEE" gene located on chromosome 2 . (wikidoc.org)
  • Mechanistically, an upregulation of indoleamine 2,3-dioxigenase in dendritic cells that accumulate in the dorsal root leptomeninges leads to an increase in levels of kynurenine (Kyn) in the spinal cord. (painresearchforum.org)
  • Abstract: Delayed increases in the levels of an endogenous N‐methyl‐D‐aspartate receptor agonist, quinolinic acid (QUIN), have been demonstrated following transient ischemia in the gerbil and were postulated to be secondary to induction of indoleamine‐2,3‐dioxygenase (IDO) and other enzymes of the L‐tryptophan‐kynurenine pathway. (fujita-hu.ac.jp)
  • These enzymes are poly(ADP-ribose) polymerase 1 (PARP1 through PARP18), the NAD-dependent deacetylases (sirtuin 1 through sirtuin 7), the ADP ribosyl-cyclases (CD38 and CD157), and indoleamine 2,3-dioxygenase (IDO). (basicmedicalkey.com)
  • Finally, using the hybrid quantum-mechanics/molecular-mechanics (QM/MM) calculations the 3HAO catalysed 3-Ohaa oxidation into 2-amino-3-carboxymuconic acid semialdehyde was elucidated. (rsc.org)
  • Other names in common use include 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3-hydroxyanthranilic acid oxidase and 3HAO. (wikipedia.org)
  • Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (uniprot.org)
  • 3-hydroxyanthranilate + O 2 = 2-amino-3-carboxymuconate semialdehyde. (uniprot.org)
  • 2-amino-3-carboxymuconic acid semialdehyde is an intermediate metabolite of the tryptophan-niacin catabolic pathway. (hmdb.ca)
  • Quinolinate is a neurotoxin formed nonenzymatically from 2-amino-3-carboxymuconic semialdehyde in mammalian tissues. (hmdb.ca)
  • 2-Amino-3-carboxymuconic semialdehyde is enzymatically converted to 2-aminomuconate via 2-aminomuconic semialdehyde. (hmdb.ca)
  • Kynureninase converts l -hydroxykynurenine to 3-hydroxyanthranilic acid that is further metabolized by hydroxyanthranilate dioxygenase to aminocarboxymuconic semialdehyde. (frontiersin.org)
  • The first three of these enzymes produce nicotinamide as a side product that is recycled back to NAD via the salvage pathway as shown in Figure 24-4. (basicmedicalkey.com)
  • The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups. (bvsalud.org)
  • Marked increases in the activity of kynureninase, kynurenine 3‐hydroxylase, and 3‐hydroxyanthranilate‐3,4‐dioxygenase were also detected in hippocampus but not in cerebellum on day 4 of recirculation. (fujita-hu.ac.jp)
  • Collectively, these results support roles for IDO, kynureninase, kynurenine 3‐hydroxylase, and 3‐hydroxyanthranilate‐3,4‐dioxygenase in accelerating the conversion of L‐tryptophan and other substrates to QUIN in damaged brain regions following transient cerebral ischemia. (fujita-hu.ac.jp)
  • This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine. (uniprot.org)
  • This protein catalyzes the synthesis ofquinolinic acid (QUIN) from 3-hydroxyanthranilic acid. (creativebiomart.net)
  • 3-Hydroxyanthranilate 34-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. (bio-rad.com)
  • An increasing evidences show that stress response was observed in cattle and goat after fed high concentrate diets exhibiting higher level of acute phase proteins including serum amyloid A (SAA) and C-reactive protein (CRP) [ 4 - 6 ]. (biomedcentral.com)
  • Zusätzlich bieten wir Ihnen 3-Oxoacid CoA Transferase 1 Proteine (9) und 3-Oxoacid CoA Transferase 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • [4] [5] The H-protein forms a complex with the T-protein that uses tetrahydrofolate and yields ammonia and 5,10-methylenetetrahydrofolate . (wikipedia.org)
  • The "MCEE" gene is located in the 2p13 region and contains 4 exons , and encodes for a protein that is approximately 18 kDa in size and located to the mitochondrial matrix . (wikidoc.org)
  • It catalyses the cleavage of the benzene ring of 3-hydroxyanthranilic acid (3-Ohaa), an intermediate in the kynurenine pathway, and therefore represents a potential target in treating numerous disorders related to the concentration of quinolinic acid (QUIN), the kynurenine pathway product, in tissues. (rsc.org)
  • Ultimately, 3-hydroxyanthranilate 3,4-dioxygenase-derived quinolinic acid, the final step of the canonical KYNPATH, is also involved in neuropathic pain development through the activation of glutamatergic NMDA receptors. (painresearchforum.org)
  • In the next steps, Kyn is further converted to other active metabolites, such as hydroxykynurenine, anthranilic acid, kynurenic acid, 3-hydroxyanthranilic acid, quinolinic acid, and picolinic acid (Figure 1 A). The two end-products of the pathway are NAD + and ATP that both fuel cellular metabolism ( 2 ). (frontiersin.org)
  • The substrate range and the subunit structure are unique among those of the known ring cleavage dioxygenases. (asm.org)
  • This reaction, and by extension the glycine cleavage system, is required for photorespiration in C 3 plants. (wikipedia.org)
  • [3] The glycine cleavage system is constantly present in the leaves of plants, but in small amounts until they are exposed to light. (wikipedia.org)
  • Morar, M. , White, R. H. , and Ealick, S. E. (2007) Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids . (cornell.edu)
  • [4] The amide group of glutamate is a nitrogen source for the synthesis of glutamine pathway metabolites . (wikipedia.org)
  • Zhang, Y. , Colabroy, K. L. , Begley, T. P. , and Ealick, S. E. (2005) Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis . (anl.gov)
  • In the spinal cord, Kyn is metabolized by astrocyte-expressed kynurenine-3-monooxygenase into a pro-nociceptive metabolite 3-hydroxykynurenine. (painresearchforum.org)
  • In vivo and in vitro data indicated that IDO1 regulates vascular inflammation, particularly in smooth muscle cells, and inhibits atherosclerosis possibly via the generation of the metabolite 3-hydroxyanthranilic acid (3HAA). (wesrch.com)
  • He also holds a patent "Small Inhibitors of Kynurenine 3-Monooxygenase" and has a patent "A new class of 3-hydroxyanthranilate-3,4-dioxygenase (3-HAO) inhibitors as potential neuroprotective drugs" pending. (jpn.ca)
  • Brain tissue QUIN levels at 4 days postischemia exceeded blood concentrations, minimizing a role for breakdown of the blood-brain barrier. (fujita-hu.ac.jp)
  • In vivo synthesis of [ 13 C 6 ]QUIN was demonstrated, using mass spectrometry, in hippocampus but not in cerebellum of 4‐day postischemic animals 1 h after intracisternal administration of L‐[ 13 C 6 ]tryptophan. (fujita-hu.ac.jp)
  • However, accumulation of QUIN was demonstrated in both cerebellum and hippocampus of control gerbils following an intracisternal injection of 3‐hydroxyanthranilic acid, which verifies the availability of precursor to both regions when administered intracisternally. (fujita-hu.ac.jp)
  • [4] The hydrolysis of ATP drives [8] the first step of a two-part, concerted mechanism. (wikipedia.org)
  • [4] Another possible reaction is upon NH 2 OH binding to GS, rather than NH 4 +, yields γ-glutamylhydroxamate. (wikipedia.org)
  • To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants in the CETP (显示 CETP ELISA试剂盒 ) gene, both alone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR ) gene. (antibodies-online.cn)
  • Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). (string-db.org)
  • Vitamins B 3 (niacin), B 2 (riboflavin), and B 1 (thiamin or thiamine) are ultimately used by just over 400, 150, and 20 different proteins, respectively, and are thus intimately connected in essential bioenergetic, anabolic, and catabolic pathways. (basicmedicalkey.com)
  • Eastman CL, Guilarte TR (1990) The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine. (springer.com)
  • In vitro experiments suggested that the Treg molecule cytotoxic Tlymphocyte-associated antigen-4 (CTLA-4) regulates IDO1 expression in macrophages and vascular cells. (wesrch.com)
  • McpP has a CACHE-type LBD, and we present data indicating that CACHE-containing chemoreceptors of other species also mediate taxis to C 2 and C 3 carboxylic acids. (asm.org)
  • Ishii T, Iwahashi H, Sugata R et al (1992) Formation of hydroxanthommatin-derived radical in the oxidation of 3-hydroxykynurenine. (springer.com)
  • Based on previous findings, it was hypothesized that low vitamin B-6 status decreases n-6/n-3 long chain polyunsaturated fatty acids (LCPUFAs) but increases their precursors, linoleic acid and a-linolenic acid in both blood lipids and cultured human hepatoma (HepG2) cell line by impairing LCPUFA synthesis. (ufl.edu)
  • Auf www.antikoerper-online.de finden Sie aktuell 57 3-Oxoacid CoA Transferase 1 (OXCT1) Antikörper von 16 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Insgesamt sind aktuell 76 3-Oxoacid CoA Transferase 1 Produkte verfügbar. (antikoerper-online.de)
  • 3-ketoacid CoA transferase ( SCOT ) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them. (antikoerper-online.de)
  • 3-ketoacid CoA transferase is associated with Ketoacidosis. (antikoerper-online.de)
  • 42 3-Oxoacid CoA Transferase 1 (OXCT1) Anticorps de 7 fabricants sont disponibles sur www.anticorps-enligne.fr. (anticorps-enligne.fr)
  • The biochemical function and regulation of indolamine-2,3-dioxygenase 1 (IDO1). (frontiersin.org)
  • 3-Hydroxyanthranilate-3,4-dioxygenase activity was unchanged in the brain, lung, and liver. (fujita-hu.ac.jp)
  • However, apart from alpha-fetoprotein (AFP) only a few serological markers are available in clinical practice (such as Glypican-3, miR-21, fucosylated GP73, α-fucosidase) with AFP diagnostics remaining unsatisfactory because of its low sensitivity and the non-specific correlation between the clinical behavior of HCC and AFP blood levels. (biomedcentral.com)
  • Although tumor suppressor genes can be inactivated by deletions and/or mutations in cancer cells, epigenetic mechanisms including aberrant methylation of CpG sites within the promoter region also contribute to gene silencing [ 3 , 4 ]. (pubmedcentralcanada.ca)
  • Data show that missense mutation c.299G>A changes serine in the acyltransferase NHX4D motif of AGPAT2, and intronic c.493-1G>C mutation destroy a splicing site that leads to exon 4 skipping and deletion of whole AGPAT2 substrate binding domain. (antibodies-online.cn)
  • Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. (mybiosource.com)
  • phosphoinositide-3-kinase interacting pr. (broadinstitute.org)
  • Data suggest that AGPAT2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K)/protooncogene c-Akt and PPARgamma signaling in early stage of adipogenesis. (antibodies-online.cn)
  • Here we test for the chemotaxis of this strain towards six chloro-nitroaromatic compounds (CNACs), namely 2-chloro-4-nitrophenol (2C4NP), 2-chloro-3-nitrophenol (2C3NP), 4-chloro-2-nitrophenol (4C2NP), 2-chloro-4-nitrobenzoate (2C4NB), 4-chloro-2-nitrobenzoate (4C2NB) and 5-chloro-2-nitrobenzoate (5C2NB), and examine its relationship to the degradation of such compounds. (biomedcentral.com)