3-Deoxy-7-Phosphoheptulonate Synthase
Hemoglobin A
Citrate (si)-Synthase
Glycogen Synthase
Saccharomyces cerevisiae
Aldehyde-Lyases
Saccharomyces cerevisiae Proteins
Fructose-Bisphosphate Aldolase
Chromomycin A3
Odontogenic Cysts
Cysts found in the jaws and arising from epithelium involved in tooth formation. They include follicular cysts (e.g., primordial cyst, dentigerous cyst, multilocular cyst), lateral periodontal cysts, and radicular cysts. They may become keratinized (odontogenic keratocysts). Follicular cysts may give rise to ameloblastomas and, in rare cases, undergo malignant transformation.
Reticular Formation
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Desulfovibrio vulgaris
Desulfovibrio
Staphylococcaceae
Computational Biology
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Amino Acid Motifs
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Algorithms
Pyrococcus furiosus
Pyrococcus
Phenylalanine
Myo-Inositol-1-Phosphate Synthase
Metal-catalyzed oxidation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli: inactivation and destabilization by oxidation of active-site cysteines. (1/95)
The in vitro instability of the phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase [DAHPS(Phe)] from Escherichia coli has been found to be due to a metal-catalyzed oxidation mechanism. DAHPS(Phe) is one of three differentially feedback-regulated isoforms of the enzyme which catalyzes the first step of aromatic biosynthesis, the formation of DAHP from phosphoenolpyruvate and D-erythrose-4-phosphate. The activity of the apoenzyme decayed exponentially, with a half-life of about 1 day at room temperature, and the heterotetramer slowly dissociated to the monomeric state. The enzyme was stabilized by the presence of phosphoenolpyruvate or EDTA, indicating that in the absence of substrate, a trace metal(s) was the inactivating agent. Cu2+ and Fe2+, but none of the other divalent metals that activate the enzyme, greatly accelerated the rate of inactivation and subunit dissociation. Both anaerobiosis and the addition of catalase significantly reduced Cu2+-catalyzed inactivation. In the spontaneously inactivated enzyme, there was a net loss of two of the seven thiols per subunit; this value increased with increasing concentrations of added Cu2+. Dithiothreitol completely restored the enzymatic activity and the two lost thiols in the spontaneously inactivated enzyme but was only partially effective in reactivation of the Cu2+-inactivated enzyme. Mutant enzymes with conservative replacements at either of the two active-site cysteines, Cys61 or Cys328, were insensitive to the metal attack. Peptide mapping of the Cu2+-inactivated enzyme revealed a disulfide linkage between these two cysteine residues. All results indicate that DAHPS(Phe) is a metal-catalyzed oxidation system wherein bound substrate protects active-site residues from oxidative attack catalyzed by bound redox metal cofactor. A mechanism of inactivation of DAHPS is proposed that features a metal redox cycle that requires the sequential oxidation of its two active-site cysteines. (+info)UV light selectively coinduces supply pathways from primary metabolism and flavonoid secondary product formation in parsley. (2/95)
The UV light-induced synthesis of UV-protective flavonoids diverts substantial amounts of substrates from primary metabolism into secondary product formation and thus causes major perturbations of the cellular homeostasis. Results from this study show that the mRNAs encoding representative enzymes from various supply pathways are coinduced in UV-irradiated parsley cells (Petroselinum crispum) with two mRNAs of flavonoid glycoside biosynthesis, encoding phenylalanine ammonia-lyase and chalcone synthase. Strong induction was observed for mRNAs encoding glucose 6-phosphate dehydrogenase (carbohydrate metabolism, providing substrates for the shikimate pathway), 3-deoxyarabinoheptulosonate 7-phosphate synthase (shikimate pathway, yielding phenylalanine), and acyl-CoA oxidase (fatty acid degradation, yielding acetyl-CoA), and moderate induction for an mRNA encoding S-adenosyl-homocysteine hydrolase (activated methyl cycle, yielding S-adenosyl-methionine for B-ring methylation). Ten arbitrarily selected mRNAs representing various unrelated metabolic activities remained unaffected. Comparative analysis of acyl-CoA oxidase and chalcone synthase with respect to mRNA expression modes and gene promoter structure and function revealed close similarities. These results indicate a fine-tuned regulatory network integrating those functionally related pathways of primary and secondary metabolism that are specifically required for protective adaptation to UV irradiation. Although the response of parsley cells to UV light is considerably broader than previously assumed, it contrasts greatly with the extensive metabolic reprogramming observed previously in elicitor-treated or fungus-infected cells. (+info)Expression of tryptophan decarboxylase and tyrosine decarboxylase genes in tobacco results in altered biochemical and physiological phenotypes. (3/95)
The substrate specificity of tryptophan (Trp) decarboxylase (TDC) for Trp and tyrosine (Tyr) decarboxylase (TYDC) for Tyr was used to modify the in vivo pools of these amino acids in transgenic tobacco. Expression of TDC and TYDC was shown to deplete the levels of Trp and Tyr, respectively, during seedling development. The creation of artificial metabolic sinks for Trp and Tyr also drastically affected the levels of phenylalanine, as well as those of the non-aromatic amino acids methionine, valine, and leucine. Transgenic seedlings also displayed a root-curling phenotype that directly correlated with the depletion of the Trp pool. Non-transformed control seedlings could be induced to display this phenotype after treatment with inhibitors of auxin translocation such as 2,3,5-triiodobenzoic acid or N-1-naphthylphthalamic acid. The depletion of aromatic amino acids was also correlated with increases in the activities of the shikimate and phenylpropanoid pathways in older, light-treated transgenic seedlings expressing TDC, TYDC, or both. These results provide in vivo confirmation that aromatic amino acids exert regulatory feedback control over carbon flux through the shikimate pathway, as well as affecting pathways outside of aromatic amino acid biosynthesis. (+info)Histidine 268 in 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase plays the same role as histidine 202 in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. (4/95)
The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAH 7-P) synthase (Phe) is inactivated by diethyl pyrocarbonate (DEPC). The inactivation is first order with respect to enzyme and DEPC concentrations with a pseudo-second order rate constant of inactivation by DEPC of 4.9 +/- 0.8 m(-1) s(-1) at pH 6.8 and 4 degrees C. The dependence of inactivation on pH and the spectral features of enzyme modified at specific pH values imply that both histidine and cysteine residues are modified, which is confirmed by site-directed mutagenesis. Analysis of the chemical modification data indicates that one histidine is essential for activity. DAH 7-P synthase (Phe) is protected against DEPC inactivation by phosphoenolpyruvate, whereas d-erythrose 4-phosphate offers only minimal protection. The conserved residues H-172, H-207, H-268, and H-304 were individually mutated to glycine. The H304G and H207G mutants retain some level of activity, whereas the H268G and H172G mutants are virtually inactive. A comparison of the circular dichroism spectra of wild-type enzyme and the various mutants demonstrates that H-172 may play a structural role. Comparison of the UV spectra of the H268G and wild-type enzymes saturated with Cu(2+) indicates that the metal-binding site of the H268G mutant resembles that of the wild-type enzyme. The residue H-268 may play a catalytic role based on the site-directed mutagenesis and spectroscopic studies. Cysteine 61 appears to influence the pK(a) of H-268 in the wild-type enzyme. The pK(a) of H-268 increases from 6.0 to 7.0 following mutation of C-61 to glycine. (+info)Microbial origin of plant-type 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate synthases, exemplified by the chorismate- and tryptophan-regulated enzyme from Xanthomonas campestris. (5/95)
Enzymes performing the initial reaction of aromatic amino acid biosynthesis, 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthases, exist as two distinct homology classes. The three classic Escherichia coli paralogs are AroA(I) proteins, but many members of the Bacteria possess the AroA(II) class of enzyme, sometimes in combination with AroA(I) proteins. AroA(II) DAHP synthases until now have been shown to be specifically dedicated to secondary metabolism (e.g., formation of ansamycin antibiotics or phenazine pigment). In contrast, here we show that the Xanthomonas campestris AroA(II) protein functions as the sole DAHP synthase supporting aromatic amino acid biosynthesis. X. campestris AroA(II) was cloned in E. coli by functional complementation, and genes corresponding to two possible translation starts were expressed. We developed a 1-day partial purification method (>99%) for the unstable protein. The recombinant AroA(II) protein was found to be subject to an allosteric pattern of sequential feedback inhibition in which chorismate is the prime allosteric effector. L-Tryptophan was found to be a minor feedback inhibitor. An N-terminal region of 111 amino acids may be located in the periplasm since a probable inner membrane-spanning region is predicted. Unlike chloroplast-localized AroA(II) of higher plants, X. campestris AroA(II) was not hysteretically activated by dithiols. Compared to plant AroA(II) proteins, differences in divalent metal activation were also observed. Phylogenetic tree analysis shows that AroA(II) originated within the Bacteria domain, and it seems probable that higher-plant plastids acquired AroA(II) from a gram-negative bacterium via endosymbiosis. The X. campestris AroA(II) protein is suggested to exemplify a case of analog displacement whereby an ancestral aroA(I) species was discarded, with the aroA(II) replacement providing an alternative pattern of allosteric control. Three subgroups of AroA(II) proteins can be recognized: a large, central group containing the plant enzymes and that from X. campestris, one defined by a three-residue deletion near the conserved KPRS motif, and one possessing a larger deletion further downstream. (+info)The ARO4 gene of Candida albicans encodes a tyrosine-sensitive DAHP synthase: evolution, functional conservation and phenotype of Aro3p-, Aro4p-deficient mutants. (6/95)
The enzyme 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP) synthase catalyses the first step in aromatic amino acid biosynthesis in prokaryotes, plants and fungi. Cells of Saccharomyces cerevisiae contain two catalytically redundant DAHP synthases, encoded by the genes ARO3 and ARO4, whose activities are feedback-inhibited by phenylalanine and tyrosine, respectively. ARO3/4 gene transcription is controlled by GCN4. The authors previously cloned an ARO3 gene orthologue from Candida albicans and found that: (1) it can complement an aro3 aro4 double mutation in S. cerevisiae, an effect inhibited by excess phenylalanine, and (2) a homozygous aro3-deletion mutant of C. albicans is phenotypically Aro(+), suggesting the existence of another isozyme(s). They now report the identification and functional characterization of the C. albicans orthologue of S. cerevisiae Aro4p. The two Aro4p enzymes share 68% amino acid identity. Phylogenetic analysis places the fungal DAHP synthases in a cluster separate from prokaryotic orthologues and suggests that ARO3 and ARO4 arose from a single gene via a gene duplication event early in fungal evolution. C. albicans ARO4 mRNA is elevated upon amino acid starvation, consistent with the presence of three putative Gcn4p-responsive elements (GCREs) in the gene promoter sequence. C. albicans ARO4 complements an aro3 aro4 double mutation in S. cerevisiae, an effect inhibited by excess tyrosine. The authors engineered Deltaaro3/Deltaaro3 Deltaaro4/MET3p::ARO4 cells of C. albicans (with one wild-type copy of ARO4 placed under control of the repressible MET3 promoter) and found that they fail to grow in the absence of aromatic amino acids when ARO4 expression is repressed, and that this growth defect can be partially rescued by aromatic amino acids and certain aromatic amino acid pathway intermediates. It is concluded that, like S. cerevisiae, C. albicans contains two DAHP synthases required for the first step in the aromatic amino acid biosynthetic pathway. (+info)Properties of tyrosine-inhibitable 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthase from Salmonella. (7/95)
Tyrosine-inhibitable 3-deoxy-D-arabinoheptulosonic acid-7-phosphate (DAHP) synthase was purified to homogeneity without significant loss of sensitivity to inhibition by tyrosine from an operator-constitutive strain (tyrOc) of Salmonella. The enzyme had an apparent molecular weight of 76,000 by gel filtration and a subunit molecular weight of 40,000 by sodium dodecyl sulfate-gel electrophoresis and by reaction with dimethyl suberimidate. It had an isoelectric point of 4.68. Inhibition by L-tyrosine showed a Hill coefficient of 1.8 at pH 7.0, suggesting cooperative interaction between tyrosine-binding sites, and was competitive with phosphoenol pyruvate and noncompetitive with erythrose-4-phosphate. (+info)Redox regulation of Arabidopsis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (8/95)
The cDNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of Arabidopsis encodes a polypeptide with an amino-terminal signal sequence for plastid import. A cDNA fragment encoding the processed form of the enzyme was expressed in Escherichia coli. The resulting protein was purified to electrophoretic homogeneity. The enzyme requires Mn(2+) and reduced thioredoxin (TRX) for activity. Spinach (Spinacia oleracea) TRX f has an apparent dissociation constant for the enzyme of about 0.2 microM. The corresponding constant for TRX m is orders of magnitude higher. In the absence of TRX, dithiothreitol partially activates the enzyme. Upon alkylation of the enzyme with iodoacetamide, the dependence on a reducing agent is lost. These results indicate that the first enzyme in the shikimate pathway of Arabidopsis appears to be regulated by the ferredoxin/TRX redox control of the chloroplast. (+info)
DAHP synthase - Wikipedia
Isolation and biochemical characterization of a metagenome-derived 3-deoxy- d -arabino-heptulosonate-7-phosphate synthase gene...
Structure Cluster
- 1OFB: CRYSTAL STRUCTURE OF THE TYROSINE-REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE...
Agriculture and Plant Genetics | Yeda Research and Development Company Ltd.
RCSB PDB
- 1ZCO: Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase...
Erythrose 4-phosphate - Wikipedia
Wounding induces the first enzyme of the shikimate pathway in Solanaceae | PNAS
UniProt: A0A1V1RDQ8 9ACTN
ARO3 - Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited - Saccharomyces cerevisiae (strain ATCC 204508 /...
1ofa.1 | SWISS-MODEL Template Library
S. aureus Expression Data Browser
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UV-B induced transcript accumulation of DAHP synthase in suspension-cultured Catharanthus roseus cells
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Pseudomonas sRNA P15
P15 has a predicted Rho independent terminator at the 3′ end but the function of P15 is unknown. Pseudomonas sRNA P1 ... P15 is conserved across several Pseudomonas species and is consistently located upstream of a 3-deoxy-7-phosphoheptulonate ... synthase gene. ...
DAHP synthase
DAH7-P synthase, DAHP synthase, DS-Co, DS-Mn, KDPH synthase, KDPH synthetase, deoxy-D-arabino-heptulosonate-7-phosphate ... Metal ions are required in order for DAHP synthase to catalyze reactions.[2] In DAHP synthase, it has been shown that binding ... The quaternary structure of DAHP synthase consists of two tightly bound dimers, which means that DAHP synthase is a tetramer.[5 ... To the right is an image of DAHP synthase that shows the quaternary structure of DAHP synthase. This image shows that DAHP ...
List of EC numbers (EC 2)
... acetolactate synthase EC 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase EC 2.2.1.8: fluorothreonine transaldolase EC 2.2.1.9 ... synthase EC 2.3.3.2: decylcitrate synthase EC 2.3.3.3: citrate (Re)-synthase EC 2.3.3.4: decylhomocitrate synthase EC 2.3.3.5: ... synthase EC 2.4.1.12: cellulose synthase (UDP-forming) EC 2.4.1.13: sucrose synthase EC 2.4.1.14: sucrose-phosphate synthase EC ... squalene synthase EC 2.5.1.22: spermine synthase EC 2.5.1.23: sym-norspermidine synthase EC 2.5.1.24: discadenine synthase EC ...
DAHP synthase - Wikipedia
DAH7-P synthase, DAHP synthase, DS-Co, DS-Mn, KDPH synthase, KDPH synthetase, deoxy-D-arabino-heptulosonate-7-phosphate ... Metal ions are required in order for DAHP synthase to catalyze reactions.[2] In DAHP synthase, it has been shown that binding ... The quaternary structure of DAHP synthase consists of two tightly bound dimers, which means that DAHP synthase is a tetramer.[5 ... To the right is an image of DAHP synthase that shows the quaternary structure of DAHP synthase. This image shows that DAHP ...
The Functional Unit of Neisseria Meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric
Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (NmeDAH7PS) adopts a homotetrameric structure ... The Functional Unit of Neisseria Meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric PLoS One. 2016 ... Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (NmeDAH7PS) adopts a homotetrameric structure ...
ARO3 - Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited - Saccharomyces cerevisiae (strain ATCC 204508 /...
... giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). ... Chorismate synthase (ARO2). This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic ... Belongs to the class-I DAHP synthase family.Curated. Phylogenomic databases. evolutionary genealogy of genes: Non-supervised ... Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibitedAdd BLAST. 370. Proteomic databases. MaxQB - The MaxQuant ...
aroH - Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive - Escherichia coli (strain K12) - aroH gene & protein
... giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). ... Chorismate synthase (aroC). This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic ... Belongs to the class-I DAHP synthase family.Curated. Phylogenomic databases. evolutionary genealogy of genes: Non-supervised ... 3. EBI-1125143,EBI-543750. GO - Molecular functioni. *identical protein binding Source: EcoCycInferred from direct assayi* ...
Mechanisms of sulfadoxine resistance in Plasmodium falciparum
ARO4 | SGD
... synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high ... 3-deoxy-7-phosphoheptulonate synthase implicated in chorismate biosynthesis; localizes to both nucleus and cytoplasm. View ... concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress 2 3 4 ...
Pseudomonas sRNA P15 - Wikipedia
A chalcone synthase controls the verticillium disease resistance response in both Arabidopsis thaliana and cotton | Springer...
vsad1 is a previously identified allele of the transparent testa 4 gene (tt4), which encodes chalcone synthase (CHS), a key ... A chalcone synthase controls the verticillium disease resistance response in both Arabidopsis thaliana and cotton. ... Characterization and expression of chalcone synthase gene from Ginkgo biloba. Plant Science, 168, 1525-1531.CrossRefGoogle ... Enzymatic properties and mutational studies of chalcone synthase from Physcomitrella patens. International Journal of Molecular ...
KEGG SSDB Best Search Result: bfo:BRAFLDRAFT 126138
egn:BMF35_a1970 CTP synthase K01937 545 102 ( -) 29 0.309 81 -, 1 fib:A6C57_11525 carbamoyl phosphate synthase small subu ... abam:B1s21122_03435 CTP synthase K01937 545 100 ( -) 29 0.326 92 -, 1 aep:AMC99_01220 CTP synthase K01937 544 100 ( -) 29 0.321 ... vmo:VMUT_0696 CTP synthase K01937 548 101 ( -) 29 0.347 75 -, 1 woc:BA177_01830 hypothetical protein 317 101 ( -) 29 0.317 82 ... hrb:Hrubri_2236 polyketide synthase 4172 115 ( -) 32 0.337 104 -, 1 orh:Ornrh_0096 putative N-acetylglucosamine kinase 287 115 ...
Seedless mutant 'Wuzi Ougan' (Citrus suavissima Hort. ex Tanaka 'seedless') and the wild type were compared by iTRAQ-based...
CHS (chalcone synthase) and CHI (chalcone isomerase) are rate-limiting enzymes and involved in male sterility when their ... An anther-specific chalcone synthase-like gene D 5 related to rice pollen development. Chin Sci Bull. 2000;45(21):1921-6.View ... LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in ... Kehrel B, Wiermann R. Immunochemical localization of phenylalanine ammonia-lyase and chalcone synthase in anthers. Planta. 1985 ...
Pfam:
Family: DAHP synth 1 (PF00793)
DAH7-P synthase, DAHP synthase, DS-Co, DS-Mn, KDPH synthase, KDPH synthetase, deoxy-D-arabino-heptulosonate-7-phosphate ... Metal ions are required in order for DAHP synthase to catalyze reactions.[2] In DAHP synthase, it has been shown that binding ... The quaternary structure of DAHP synthase consists of two tightly bound dimers, which means that DAHP synthase is a tetramer.[5 ... synthase His_biosynth HMGL-like IGPS IMPDH KDGP_aldolase Lys-AminoMut_A MtrH NanE NAPRTase NeuB NMO OAM_alpha OMPdecase Orn_Arg ...
HOGENOMDNA: ASFUM1 4.PE130
Transcriptional profile of Paracoccidioides spp. in response to itraconazole | BMC Genomics | Full Text
Banks IR, Specht CA, Donlin MJ, Gerik KJ, Levitz SM, Lodge JK: A chitin synthase and its regulator protein are critical for ... These components are diacylglycerol o-acyltransferase (DGAT), chitin synthase regulator 2 (CHSr), hemolysin-iii channel protein ... HSP70 and ATP synthase f0 subunit 9 (ATPS9). These genes were chosen because of their high frequency or as representatives of ... as indicated by up-regulation of DGAT and phosphatidyl synthase (PHS), which produce phospholipids. DGAT has been found in ...
ccmO protein (Gloeobacter violaceus) - STRING interaction network
Other names: G. violaceus, G. violaceus PCC 7421, Gloeobacter, Gloeobacter violaceus, Gloeobacter violaceus ATCC 29082, Gloeobacter violaceus PCC 7421, Gloeobacter violaceus str. PCC 7421, Gloeobacter violaceus strain PCC 7421, Gloeobacterales, Gloeobacterales Cavalier-Smith 2002, Gloeobacteria, Gloeobacteria Cavalier-Smith 2002 ...
1OF6 | Genus
DeCS
DAHP Synthase Phospho 2 Keto 3 Deoxyheptonate Aldolase Phospho-2-Keto-3-Deoxyheptonate Aldolase Synthase, 3-Deoxy-7- ... Phosphoheptulonate Synthase, 3-Deoxy-Arabino-Heptulosonate-7-Phosphate Synthase, 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate ... DAHP Synthase. Phospho 2 Keto 3 Deoxyheptonate Aldolase. Phospho-2-Keto-3-Deoxyheptonate Aldolase. Synthase, 3-Deoxy-7- ... Phosphoheptulonate. Synthase, 3-Deoxy-Arabino-Heptulosonate-7-Phosphate. Synthase, 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate ...
1OF8 | Genus
Результаты поиска по "Deoxy"
Результаты поиска по Deoxy. Уточнить поисковый запрос Количество Записи 15. 25. 50. 75. 100. ... 4-Deoxy-L-threo-5-hexosulose-uronate Ketol-isomerase Enzyme, Catalysis, Chemical reaction, Enzyme substrate (biology), ... 3-Deoxy-8-phosphooctulonate Synthase Enzyme, Catalysis, Chemical reaction, Enzyme substrate (biology), Phosphoenolpyruvic acid ... 3-Deoxy-7-phosphoheptulonate Synthase Metabolism, Amino acid, Phenylalanine, Tyrosine, Tryptophan, Enzyme inhibitor ...
Network Portal - Gene BSU29750
... synthase. cog/ cog. 3-deoxy-7-phosphoheptulonate synthase activity. go/ molecular_function. chorismate mutase activity. go/ ... POSITION A C G T 1 0.0 1.0 0.0 0.0 2 0.0 0.0 0.0 1.0 3 1.0 0.0 0.0 0.0 4 0.0 1.0 0.0 0.0 5 1.0 0.0 0.0 0.0 6 1.0 0.0 0.0 0.0 7 ... POSITION A C G T 1 0.0 1.0 0.0 0.0 2 0.0 0.0 1.0 0.0 3 1.0 0.0 0.0 0.0 4 0.0 0.0 1.0 0.0 5 0.0 1.0 0.0 0.0 6 0.0 0.0 1.0 0.0 ... 3-ketoacyl-(acyl-carrier-protein) reductase (RefSeq). 229, 356. BSU21700. ypoP. putative transcriptional regulator (MarR family ...
Studies on 3-Deoxy-d-arabinoheptulosonate-7-phosphate Synthetase(phe) from Escherichia coli K12. 1. Purification and Subunit...
3. Amino acid anaktsus abd tryptic fingerprints indicated that the subunits of the enzyme are very similar and possibly ... 1. 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe) from Escherichia coli K12 has been purified to near homogeneity. ... Studies on 3-Deoxy-d-arabinoheptulosonate-7-phosphate Synthetase(phe) from Escherichia coli K12. 1. Purification and Subunit ...
Network Portal - Gene GSU3213
SPFH/Band 7 domain protein (VIMSS). 23, 256. GSU2443. GSU2443. dehydrogenase complex, E1 component, alpha subunit (VIMSS). 167 ... POSITION A C G T 1 0.8 0.0 0.2 0.0 2 0.2 0.0 0.0 0.8 3 0.0 0.8 0.0 0.2 4 1.0 0.0 0.0 0.0 5 0.2 0.0 0.8 0.0 6 0.0 1.0 0.0 0.0 7 ... POSITION A C G T 1 1.0 0.0 0.0 0.0 2 0.8 0.2 0.0 0.0 3 0.0 0.0 0.8 0.2 4 0.6 0.0 0.4 0.0 5 0.8 0.2 0.0 0.0 6 0.6 0.0 0.0 0.4 7 ... POSITION A C G T 1 0.0 0.0 1.0 0.0 2 0.0 0.8 0.2 0.0 3 0.2 0.4 0.0 0.4 4 0.8 0.0 0.0 0.2 5 0.0 0.6 0.0 0.4 6 0.0 0.8 0.2 0.0 7 ...
aroF1 protein (Pseudomonas aeruginosa) - STRING interaction network
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate ( ... 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate ( ... 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate ( ... 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate ( ...
RCSB PDB
- 1ZCO: Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase...
Gene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane...
ATP synthase type III secretion protein N [EC:3.6.3.14]) but in no other rumen bacteria.. ... 2013;7:316-21.View ArticlePubMedPubMed CentralGoogle Scholar. *. Bain WE, Bezuidenhout L, Jopson NB, Pinares-Patino C, McEwan ... 1975;64:540-3.View ArticlePubMedGoogle Scholar. *. Porschen RK, Chan P. Anaerobic vibrio-like organisms cultured from blood: ... 2007;23:3251-3.View ArticlePubMedGoogle Scholar. *. R Core Team. R: a language and environment for statistical computing. ...
List of EC numbers (EC 2) - Wikipedia
... acetolactate synthase EC 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase EC 2.2.1.8: fluorothreonine transaldolase EC 2.2.1.9 ... synthase EC 2.3.3.2: decylcitrate synthase EC 2.3.3.3: citrate (Re)-synthase EC 2.3.3.4: decylhomocitrate synthase EC 2.3.3.5: ... synthase EC 2.4.1.12: cellulose synthase (UDP-forming) EC 2.4.1.13: sucrose synthase EC 2.4.1.14: sucrose-phosphate synthase EC ... squalene synthase EC 2.5.1.22: spermine synthase EC 2.5.1.23: sym-norspermidine synthase EC 2.5.1.24: discadenine synthase EC ...
Aldolase1
- Structure of Aquifex aeolicus kdo8ps in complex with z-methyl-pep 2-dehydro-3-deoxyphosphooctonate aldolase. (wikipedia.org)
DAHP16
- 3-Deoxy-D-arabinoheptulosonate 7-phosphate ( DAHP ) synthase ( EC 2.5.1.54 ) is the first enzyme in a series of metabolic reactions known as the shikimate pathway , which is responsible for the biosynthesis of the amino acids phenylalanine , tyrosine , and tryptophan . (wikipedia.org)
- [2] Forms of this enzyme differ between organisms, but can be considered DAHP synthase based upon the reaction that is catalyzed by this enzyme. (wikipedia.org)
- The primary function of DAHP synthase is to catalyze the reaction of phosphoenolpyruvate and D-erythrose 4-phosphate to DAHP and phosphate . (wikipedia.org)
- [2] Feedback inhibition and transcriptional control are both mechanisms of regulating carbon in bacteria, but the only mechanism of regulation found in DAHP synthase found in plants is transcriptional control. (wikipedia.org)
- In Escherichia coli , a species of bacteria, DAHP synthase is found as three isoenzymes , each of which sensitive to one of the amino acids produced in the shikimate pathway. (wikipedia.org)
- [3] It was also determined that the enzyme is inhibited by inorganic phosphate through noncompetitive inhibition with respect to both substrates and inhibited by DAHP through competitive inhibition with respect to phosphoenolpyruvate and noncompetitive inhibition with respect to D-erythrose 4-phosphate. (wikipedia.org)
- [3] Thus the amount of carbon entering the shikimate pathway can be controlled by inhibiting DAHP synthase from catalyzing the reaction that forms DAHP. (wikipedia.org)
- [2] In plants, as the plants progressed through the growth cycle, the activity of DAHP synthase changed. (wikipedia.org)
- Metal ions are required in order for DAHP synthase to catalyze reactions. (wikipedia.org)
- [2] In DAHP synthase, it has been shown that binding site contains patterns of cysteine and histidine residues bound to metal ions in a Cys-X-X-His fashion. (wikipedia.org)
- It has been shown that, in general, DAHP synthases require a bivalent metal ion cofactor in order for the enzyme to function properly. (wikipedia.org)
- [4] Studies have suggested that one metal ion bonds to each monomer of DAHP synthase. (wikipedia.org)
- Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). (uniprot.org)
- There are 3 DAHP synthases, AroH is feedback-inhibited by Trp. (uniprot.org)
- The other 2 DAHP synthases are Tyr- and Phe-sensitive, respectively. (uniprot.org)
- Ab7, an isoenzyme of a 3-deoxy-7-phosphoheptulonate (DAHP) synthase, is involved in chorismate biosynthesis by the shikimate pathway. (bvsalud.org)
Biosynthesis1
- vsad1 is a previously identified allele of the transparent testa 4 gene ( tt4 ), which encodes chalcone synthase (CHS), a key enzyme involved in the biosynthesis of flavonoids. (springer.com)
AROmatic1
- In the aromatic amino acid biosynthetic pathway 3-dehydroshikimate (DHS) is a key intermediate. (bvsalud.org)
Synthetase3
- Four enzymes of the respective biosynthetic chain were demonstrated in isolated plasmodia: 3-deoxy-D-arabino-heptulosonate-7-phosphate synthetase (EC 4.2.1.15), shikimate dehydrogenase (EC 1.1.1.25), shikimate kinase (EC 2.7.1.71) and pABA synthetase. (nih.gov)
- Studies on 3-Deoxy-d-arabinoheptulosonate-7-phosphate Synthetase(phe) from Escherichia coli K12. (edu.au)
- 1. 3-Deoxy-D-arabinoheptulosonate-7-phosphate synthetase(phe) from Escherichia coli K12 has been purified to near homogeneity. (edu.au)
Amino1
- 3. Amino acid anaktsus abd tryptic fingerprints indicated that the subunits of the enzyme are very similar and possibly identical. (edu.au)
Enzyme3
- The three substrates of this enzyme are phosphoenolpyruvate , D-erythrose 4-phosphate , and H 2 O , whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate . (wikipedia.org)
- [3] Studies of product inhibition have shown that phosphoenolpyruvate is the first substrate to bind to the enzyme complex, inorganic phosphate is the first product to dissociate from the enzyme complex. (wikipedia.org)
- An enzyme that catalyzes the formation of 7-phospho-2-keto-3-deoxy-D-arabinoheptonate from phosphoenolpyruvate and D-erythrose-4-phosphate. (bvsalud.org)
Hypothetical protein1
- 1.38 0.006 cg1937 - Putative secreted protein 1.22 0.015 cg3018 - Hypothetical protein 1.22 0.002 cg0451 - Putative membrane protein 1.21 0.003 cg0712 - Putative secreted protein 1.08 0.014 cg3106 - Conserved hypothetical protein 1.03 0.029 cg2391 aroG 3-Deoxy-7-phosphoheptulonate synthase -1.26 0.022 cg0203 iolE Putative myo-inosose-2. (lbl.gov)
Putative1
- CDS N E->G O3K_21210 sgrR transcriptional regulator SgrR E112/10 4518367 5211133 G->A CDS N A->T O3K_21840 inner membrane protein E112/10 4667748 5061192 G->A CDS N V->I O3K_22600 putative cell envelope opacity-associated protein E112/10 5176186 4552535 C->T CDS N R->H O3K_24910 rffA TDP-4-oxo-6-deoxy-D-glucose transaminase E112/10 174510 4279463. (lbl.gov)
Gene2
- P15 is conserved across several Pseudomonas species and is consistently located upstream of a 3-deoxy-7-phosphoheptulonate synthase gene. (wikipedia.org)
- Many studies have assessed the relationships between plant genotype and phenotype [ 3 ] using morphological differences caused by loss of function or altered expression of a single gene. (biomedcentral.com)
Tyrosine1
- Here, in this study, we investigated the effect of the co-expression of aroFFBR (3-deoxy-D-arabino-heptulosonate 7- phosphate synthase mutant with tyrosine feedback -inhibition resistance) and tktA ( Transketolase A) at different copy number on the production of DHS. (bvsalud.org)
Acid4
- The key substrate for these P450 enzymes is 2,4-dichlorophenol, which in turn is derived from the precursor 3-chloro-4-hydroxybenzoic acid. (bvsalud.org)
- Here, the biosynthetic steps leading towards 3-chloro-4-hydroxybenzoic acid were investigated by in vitro assays. (bvsalud.org)
- Three phenolic compounds 4-hydroxybenzaldehyde ( 1 ), 4-hydroxycinnamic acid ( 2 ), 4-hydroxybenzoic acid ( 3 ) and two steroids stigmast-4-en-3-one ( 4 ) and β -stigmasterol ( 5 ) were isolated from the aerial part of T. maxima . (springeropen.com)
- Among the compounds 4-hydroxycinnamic acid, 4-hydroxybenzoic acid and stigmast-4-en-3-one exhibited notable cytotoxic activity against African Green Monkey Kidney Cell line (Vero cell). (springeropen.com)
Yeast1
- Overexpression of CcHyPRP from Cajanus cajan increased resistance to multiple abiotic stresses in yeast and Arabidopsis [ 7 ]. (biomedcentral.com)
Phosphate1
- Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (NmeDAH7PS) adopts a homotetrameric structure consisting of an extensive and a less extensive interface. (nih.gov)
MRNA1
- The down-regulated expression of PvPRP1 in response to fungal infection is due to mRNA destabilization through the binding of PRP-BP ( Pv PRP1 mRNA binding protein) to a 27-nucleotide U-rich domain in the 3′ untranslated region of Pv PRP1 mRNA [ 9 ]. (biomedcentral.com)
Protein1
- The Ab8 bound substrate is chlorinated by Ab10 in meta position yielding 3-Cl-4-HBA, which is then transfered by the condensation (C) domain to the peptidyl carrier protein and released by the thioesterase (TE) domain of Ab9. (bvsalud.org)
Activity1
- Furthermore, ethanolic extract of leaves of T. maxima showed cytotoxic activity against HepG2 cancer cell line where the percentage inhibition was 29.50 ± 3.9 at the concentration of 50 μg/ml [ 3 ]. (springeropen.com)
Function1
- P15 has a predicted Rho independent terminator at the 3′ end but the function of P15 is unknown. (wikipedia.org)
Regulation1
- For example, CaHyPRP1 performs distinct dual roles as a negative regulator of basal defense and in the positive regulation of cell death in Capsicum annuum against Xanthomonas campestris [ 3 ]. (biomedcentral.com)
Potent1
- The bioactivities of the different solvent extract of T. maxima have evidenced it as a potent source of natural radical scavenger [ 7 ]. (springeropen.com)
Studies1
- Enzymatic properties and mutational studies of chalcone synthase from Physcomitrella patens . (springer.com)
Complete1
- We invite you to complete a survey that will take no more than 3 minutes. (bvsalud.org)
Growth1
- Growth occurs optimally at 80°C and pH 2.5-3. (up.ac.za)
System1
- In this paper we present new results obtained with our previously presented high-throughput parallel SPM system [3,4] that showcase two key advances that are required for a successful deployment of SPM in high-throughput metrology, defect and mask inspection. (tudelft.nl)
Found1
- [3] This method is also found in bacteria, but feedback inhibition is more prevalent. (wikipedia.org)
Categories1
- BSU29750 is enriched for 9 functions in 3 categories. (systemsbiology.net)