Chromomycin A3: Glycosidic antibiotic from Streptomyces griseus used as a fluorescent stain of DNA and as an antineoplastic agent.Odontogenic Cysts: Cysts found in the jaws and arising from epithelium involved in tooth formation. They include follicular cysts (e.g., primordial cyst, dentigerous cyst, multilocular cyst), lateral periodontal cysts, and radicular cysts. They may become keratinized (odontogenic keratocysts). Follicular cysts may give rise to ameloblastomas and, in rare cases, undergo malignant transformation.Reticular Formation: A region extending from the PONS & MEDULLA OBLONGATA through the MESENCEPHALON, characterized by a diversity of neurons of various sizes and shapes, arranged in different aggregations and enmeshed in a complicated fiber network.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Oxidoreductases, N-DemethylatingInformation Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Semiconductors: Materials that have a limited and usually variable electrical conductivity. They are particularly useful for the production of solid-state electronic devices.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Desulfovibrio vulgaris: A species of gram-negative, anaerobic, rod-shaped bacteria isolated from soil, animal intestines and feces, and fresh and salt water.Desulfovibrio: A genus of gram-negative, anaerobic, rod-shaped bacteria capable of reducing sulfur compounds to hydrogen sulfide. Organisms are isolated from anaerobic mud of fresh and salt water, animal intestines, manure, and feces.Staphylococcaceae: Family of gram-positive, facultatively anaerobic bacteria, in the order Bacillales. Genera include Gemella, Macrococcus, Salinicoccus, and STAPHYLOCOCCUS.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Amino Acid Motifs: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Hydrogenase: An enzyme found in bacteria. It catalyzes the reduction of FERREDOXIN and other substances in the presence of molecular hydrogen and is involved in the electron transport of bacterial photosynthesis.3-Deoxy-7-Phosphoheptulonate Synthase: An enzyme that catalyzes the formation of 7-phospho-2-keto-3-deoxy-D-arabinoheptonate from phosphoenolpyruvate and D-erythrose-4-phosphate. It is one of the first enzymes in the biosynthesis of TYROSINE and PHENYLALANINE. This enzyme was formerly listed as EC 4.1.2.15.Pyrococcus furiosus: A species of strictly anaerobic, hyperthermophilic archaea which lives in geothermally-heated marine sediments. It exhibits heterotropic growth by fermentation or sulfur respiration.Aldehyde-Lyases: Enzymes that catalyze a reverse aldol condensation. A molecule containing a hydroxyl group and a carbonyl group is cleaved at a C-C bond to produce two smaller molecules (ALDEHYDES or KETONES). EC 4.1.2.Pyrococcus: A genus of strictly anaerobic ultrathermophilic archaea, in the family THERMOCOCCACEAE, occurring in heated seawaters. They exhibit heterotrophic growth at an optimum temperature of 100 degrees C.Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.Myo-Inositol-1-Phosphate Synthase: An enzyme that catalyzes the formation of myo-inositol-1-phosphate from glucose-6-phosphate in the presence of NAD. EC 5.5.1.4.Pyrococcus horikoshii: Anaerobic hyperthermophilic species of ARCHAEA, isolated from hydrothermal fluid samples. It is obligately heterotrophic with coccoid cells that require TRYPTOPHAN for growth.Archaeal Proteins: Proteins found in any species of archaeon.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Hexosaminidases: Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.Man-Machine Systems: A system in which the functions of the man and the machine are interrelated and necessary for the operation of the system.5,10-Methylenetetrahydrofolate Reductase (FADH2): An FAD-dependent oxidoreductase found primarily in BACTERIA. It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This enzyme was formerly listed as EC 1.1.1.68 and 1.1.99.15.Pterygoid Muscles: Two of the masticatory muscles: the internal, or medial, pterygoid muscle and external, or lateral, pterygoid muscle. Action of the former is closing the jaws and that of the latter is opening the jaws, protruding the mandible, and moving the mandible from side to side.Neurospora crassa: A species of ascomycetous fungi of the family Sordariaceae, order SORDARIALES, much used in biochemical, genetic, and physiologic studies.Bacteriophage PRD1: Bacteriophage and type species in the genus Tectivirus, family TECTIVIRIDAE. They are specific for Gram-negative bacteria.Bridged Compounds: Cyclic hydrocarbons that contain multiple rings and share one or more atoms.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Nicotinamide N-Methyltransferase: An enzyme found primarily in the LIVER that catalyzes the N-methylation of NICOTINAMIDE and other structurally related compounds.Guanidinoacetate N-Methyltransferase: This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanidinoacetate to CREATINE.Histamine N-Methyltransferase: An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of histamine in man. EC 2.1.1.8.Glycine N-Methyltransferase: An enzyme that catalyzes the METHYLATION of GLYCINE using S-ADENOSYLMETHIONINE to form SARCOSINE with the concomitant production of S-ADENOSYLHOMOCYSTEINE.Phosphatidylethanolamine N-Methyltransferase: An enzyme that catalyses three sequential METHYLATION reactions for conversion of phosphatidylethanolamine to PHOSPHATIDYLCHOLINE.Betaine-Homocysteine S-Methyltransferase: A ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to produce dimethylglycine and METHIONINE, respectively. This enzyme is a member of a family of ZINC-dependent METHYLTRANSFERASES that use THIOLS or selenols as methyl acceptors.Methyltransferases: A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.Catechol O-Methyltransferase: Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.Acetylserotonin O-Methyltransferase: An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylserotonin to form N-acetyl-5-methoxytryptamine (MELATONIN).Phenylethanolamine N-Methyltransferase: A methyltransferase that catalyzes the reaction of S-adenosyl-L-methionine and phenylethanolamine to yield S-adenosyl-L-homocysteine and N-methylphenylethanolamine. It can act on various phenylethanolamines and converts norepinephrine into epinephrine. (From Enzyme Nomenclature, 1992) EC 2.1.1.28.
(1/95) Metal-catalyzed oxidation of phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli: inactivation and destabilization by oxidation of active-site cysteines.

The in vitro instability of the phenylalanine-sensitive 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase [DAHPS(Phe)] from Escherichia coli has been found to be due to a metal-catalyzed oxidation mechanism. DAHPS(Phe) is one of three differentially feedback-regulated isoforms of the enzyme which catalyzes the first step of aromatic biosynthesis, the formation of DAHP from phosphoenolpyruvate and D-erythrose-4-phosphate. The activity of the apoenzyme decayed exponentially, with a half-life of about 1 day at room temperature, and the heterotetramer slowly dissociated to the monomeric state. The enzyme was stabilized by the presence of phosphoenolpyruvate or EDTA, indicating that in the absence of substrate, a trace metal(s) was the inactivating agent. Cu2+ and Fe2+, but none of the other divalent metals that activate the enzyme, greatly accelerated the rate of inactivation and subunit dissociation. Both anaerobiosis and the addition of catalase significantly reduced Cu2+-catalyzed inactivation. In the spontaneously inactivated enzyme, there was a net loss of two of the seven thiols per subunit; this value increased with increasing concentrations of added Cu2+. Dithiothreitol completely restored the enzymatic activity and the two lost thiols in the spontaneously inactivated enzyme but was only partially effective in reactivation of the Cu2+-inactivated enzyme. Mutant enzymes with conservative replacements at either of the two active-site cysteines, Cys61 or Cys328, were insensitive to the metal attack. Peptide mapping of the Cu2+-inactivated enzyme revealed a disulfide linkage between these two cysteine residues. All results indicate that DAHPS(Phe) is a metal-catalyzed oxidation system wherein bound substrate protects active-site residues from oxidative attack catalyzed by bound redox metal cofactor. A mechanism of inactivation of DAHPS is proposed that features a metal redox cycle that requires the sequential oxidation of its two active-site cysteines.  (+info)

(2/95) UV light selectively coinduces supply pathways from primary metabolism and flavonoid secondary product formation in parsley.

The UV light-induced synthesis of UV-protective flavonoids diverts substantial amounts of substrates from primary metabolism into secondary product formation and thus causes major perturbations of the cellular homeostasis. Results from this study show that the mRNAs encoding representative enzymes from various supply pathways are coinduced in UV-irradiated parsley cells (Petroselinum crispum) with two mRNAs of flavonoid glycoside biosynthesis, encoding phenylalanine ammonia-lyase and chalcone synthase. Strong induction was observed for mRNAs encoding glucose 6-phosphate dehydrogenase (carbohydrate metabolism, providing substrates for the shikimate pathway), 3-deoxyarabinoheptulosonate 7-phosphate synthase (shikimate pathway, yielding phenylalanine), and acyl-CoA oxidase (fatty acid degradation, yielding acetyl-CoA), and moderate induction for an mRNA encoding S-adenosyl-homocysteine hydrolase (activated methyl cycle, yielding S-adenosyl-methionine for B-ring methylation). Ten arbitrarily selected mRNAs representing various unrelated metabolic activities remained unaffected. Comparative analysis of acyl-CoA oxidase and chalcone synthase with respect to mRNA expression modes and gene promoter structure and function revealed close similarities. These results indicate a fine-tuned regulatory network integrating those functionally related pathways of primary and secondary metabolism that are specifically required for protective adaptation to UV irradiation. Although the response of parsley cells to UV light is considerably broader than previously assumed, it contrasts greatly with the extensive metabolic reprogramming observed previously in elicitor-treated or fungus-infected cells.  (+info)

(3/95) Expression of tryptophan decarboxylase and tyrosine decarboxylase genes in tobacco results in altered biochemical and physiological phenotypes.

The substrate specificity of tryptophan (Trp) decarboxylase (TDC) for Trp and tyrosine (Tyr) decarboxylase (TYDC) for Tyr was used to modify the in vivo pools of these amino acids in transgenic tobacco. Expression of TDC and TYDC was shown to deplete the levels of Trp and Tyr, respectively, during seedling development. The creation of artificial metabolic sinks for Trp and Tyr also drastically affected the levels of phenylalanine, as well as those of the non-aromatic amino acids methionine, valine, and leucine. Transgenic seedlings also displayed a root-curling phenotype that directly correlated with the depletion of the Trp pool. Non-transformed control seedlings could be induced to display this phenotype after treatment with inhibitors of auxin translocation such as 2,3,5-triiodobenzoic acid or N-1-naphthylphthalamic acid. The depletion of aromatic amino acids was also correlated with increases in the activities of the shikimate and phenylpropanoid pathways in older, light-treated transgenic seedlings expressing TDC, TYDC, or both. These results provide in vivo confirmation that aromatic amino acids exert regulatory feedback control over carbon flux through the shikimate pathway, as well as affecting pathways outside of aromatic amino acid biosynthesis.  (+info)

(4/95) Histidine 268 in 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase plays the same role as histidine 202 in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase.

The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAH 7-P) synthase (Phe) is inactivated by diethyl pyrocarbonate (DEPC). The inactivation is first order with respect to enzyme and DEPC concentrations with a pseudo-second order rate constant of inactivation by DEPC of 4.9 +/- 0.8 m(-1) s(-1) at pH 6.8 and 4 degrees C. The dependence of inactivation on pH and the spectral features of enzyme modified at specific pH values imply that both histidine and cysteine residues are modified, which is confirmed by site-directed mutagenesis. Analysis of the chemical modification data indicates that one histidine is essential for activity. DAH 7-P synthase (Phe) is protected against DEPC inactivation by phosphoenolpyruvate, whereas d-erythrose 4-phosphate offers only minimal protection. The conserved residues H-172, H-207, H-268, and H-304 were individually mutated to glycine. The H304G and H207G mutants retain some level of activity, whereas the H268G and H172G mutants are virtually inactive. A comparison of the circular dichroism spectra of wild-type enzyme and the various mutants demonstrates that H-172 may play a structural role. Comparison of the UV spectra of the H268G and wild-type enzymes saturated with Cu(2+) indicates that the metal-binding site of the H268G mutant resembles that of the wild-type enzyme. The residue H-268 may play a catalytic role based on the site-directed mutagenesis and spectroscopic studies. Cysteine 61 appears to influence the pK(a) of H-268 in the wild-type enzyme. The pK(a) of H-268 increases from 6.0 to 7.0 following mutation of C-61 to glycine.  (+info)

(5/95) Microbial origin of plant-type 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate synthases, exemplified by the chorismate- and tryptophan-regulated enzyme from Xanthomonas campestris.

Enzymes performing the initial reaction of aromatic amino acid biosynthesis, 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthases, exist as two distinct homology classes. The three classic Escherichia coli paralogs are AroA(I) proteins, but many members of the Bacteria possess the AroA(II) class of enzyme, sometimes in combination with AroA(I) proteins. AroA(II) DAHP synthases until now have been shown to be specifically dedicated to secondary metabolism (e.g., formation of ansamycin antibiotics or phenazine pigment). In contrast, here we show that the Xanthomonas campestris AroA(II) protein functions as the sole DAHP synthase supporting aromatic amino acid biosynthesis. X. campestris AroA(II) was cloned in E. coli by functional complementation, and genes corresponding to two possible translation starts were expressed. We developed a 1-day partial purification method (>99%) for the unstable protein. The recombinant AroA(II) protein was found to be subject to an allosteric pattern of sequential feedback inhibition in which chorismate is the prime allosteric effector. L-Tryptophan was found to be a minor feedback inhibitor. An N-terminal region of 111 amino acids may be located in the periplasm since a probable inner membrane-spanning region is predicted. Unlike chloroplast-localized AroA(II) of higher plants, X. campestris AroA(II) was not hysteretically activated by dithiols. Compared to plant AroA(II) proteins, differences in divalent metal activation were also observed. Phylogenetic tree analysis shows that AroA(II) originated within the Bacteria domain, and it seems probable that higher-plant plastids acquired AroA(II) from a gram-negative bacterium via endosymbiosis. The X. campestris AroA(II) protein is suggested to exemplify a case of analog displacement whereby an ancestral aroA(I) species was discarded, with the aroA(II) replacement providing an alternative pattern of allosteric control. Three subgroups of AroA(II) proteins can be recognized: a large, central group containing the plant enzymes and that from X. campestris, one defined by a three-residue deletion near the conserved KPRS motif, and one possessing a larger deletion further downstream.  (+info)

(6/95) The ARO4 gene of Candida albicans encodes a tyrosine-sensitive DAHP synthase: evolution, functional conservation and phenotype of Aro3p-, Aro4p-deficient mutants.

The enzyme 3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP) synthase catalyses the first step in aromatic amino acid biosynthesis in prokaryotes, plants and fungi. Cells of Saccharomyces cerevisiae contain two catalytically redundant DAHP synthases, encoded by the genes ARO3 and ARO4, whose activities are feedback-inhibited by phenylalanine and tyrosine, respectively. ARO3/4 gene transcription is controlled by GCN4. The authors previously cloned an ARO3 gene orthologue from Candida albicans and found that: (1) it can complement an aro3 aro4 double mutation in S. cerevisiae, an effect inhibited by excess phenylalanine, and (2) a homozygous aro3-deletion mutant of C. albicans is phenotypically Aro(+), suggesting the existence of another isozyme(s). They now report the identification and functional characterization of the C. albicans orthologue of S. cerevisiae Aro4p. The two Aro4p enzymes share 68% amino acid identity. Phylogenetic analysis places the fungal DAHP synthases in a cluster separate from prokaryotic orthologues and suggests that ARO3 and ARO4 arose from a single gene via a gene duplication event early in fungal evolution. C. albicans ARO4 mRNA is elevated upon amino acid starvation, consistent with the presence of three putative Gcn4p-responsive elements (GCREs) in the gene promoter sequence. C. albicans ARO4 complements an aro3 aro4 double mutation in S. cerevisiae, an effect inhibited by excess tyrosine. The authors engineered Deltaaro3/Deltaaro3 Deltaaro4/MET3p::ARO4 cells of C. albicans (with one wild-type copy of ARO4 placed under control of the repressible MET3 promoter) and found that they fail to grow in the absence of aromatic amino acids when ARO4 expression is repressed, and that this growth defect can be partially rescued by aromatic amino acids and certain aromatic amino acid pathway intermediates. It is concluded that, like S. cerevisiae, C. albicans contains two DAHP synthases required for the first step in the aromatic amino acid biosynthetic pathway.  (+info)

(7/95) Properties of tyrosine-inhibitable 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthase from Salmonella.

Tyrosine-inhibitable 3-deoxy-D-arabinoheptulosonic acid-7-phosphate (DAHP) synthase was purified to homogeneity without significant loss of sensitivity to inhibition by tyrosine from an operator-constitutive strain (tyrOc) of Salmonella. The enzyme had an apparent molecular weight of 76,000 by gel filtration and a subunit molecular weight of 40,000 by sodium dodecyl sulfate-gel electrophoresis and by reaction with dimethyl suberimidate. It had an isoelectric point of 4.68. Inhibition by L-tyrosine showed a Hill coefficient of 1.8 at pH 7.0, suggesting cooperative interaction between tyrosine-binding sites, and was competitive with phosphoenol pyruvate and noncompetitive with erythrose-4-phosphate.  (+info)

(8/95) Redox regulation of Arabidopsis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

The cDNA for 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of Arabidopsis encodes a polypeptide with an amino-terminal signal sequence for plastid import. A cDNA fragment encoding the processed form of the enzyme was expressed in Escherichia coli. The resulting protein was purified to electrophoretic homogeneity. The enzyme requires Mn(2+) and reduced thioredoxin (TRX) for activity. Spinach (Spinacia oleracea) TRX f has an apparent dissociation constant for the enzyme of about 0.2 microM. The corresponding constant for TRX m is orders of magnitude higher. In the absence of TRX, dithiothreitol partially activates the enzyme. Upon alkylation of the enzyme with iodoacetamide, the dependence on a reducing agent is lost. These results indicate that the first enzyme in the shikimate pathway of Arabidopsis appears to be regulated by the ferredoxin/TRX redox control of the chloroplast.  (+info)

*  Pseudomonas sRNA P15
P15 has a predicted Rho independent terminator at the 3' end but the function of P15 is unknown. Pseudomonas sRNA P1 ... P15 is conserved across several Pseudomonas species and is consistently located upstream of a 3-deoxy-7-phosphoheptulonate ... synthase gene. ...
*  List of EC numbers (EC 2)
... acetolactate synthase EC 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase EC 2.2.1.8: fluorothreonine transaldolase EC 2.2.1.9 ... synthase EC 2.3.3.2: decylcitrate synthase EC 2.3.3.3: citrate (Re)-synthase EC 2.3.3.4: decylhomocitrate synthase EC 2.3.3.5: ... synthase EC 2.4.1.12: cellulose synthase (UDP-forming) EC 2.4.1.13: sucrose synthase EC 2.4.1.14: sucrose-phosphate synthase EC ... squalene synthase EC 2.5.1.22: spermine synthase EC 2.5.1.23: sym-norspermidine synthase EC 2.5.1.24: discadenine synthase EC ...
DAHP synthase - Wikipedia  DAHP synthase - Wikipedia
DAH7-P synthase, DAHP synthase, DS-Co, DS-Mn, KDPH synthase, KDPH synthetase, deoxy-D-arabino-heptulosonate-7-phosphate ... Metal ions are required in order for DAHP synthase to catalyze reactions.[2] In DAHP synthase, it has been shown that binding ... The quaternary structure of DAHP synthase consists of two tightly bound dimers, which means that DAHP synthase is a tetramer.[5 ... To the right is an image of DAHP synthase that shows the quaternary structure of DAHP synthase. This image shows that DAHP ...
more infohttps://en.wikipedia.org/wiki/3-deoxy-7-phosphoheptulonate_synthase
aroH - Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive - Escherichia coli (strain K12) - aroH gene & protein  aroH - Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive - Escherichia coli (strain K12) - aroH gene & protein
... giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). ... Chorismate synthase (aroC). This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic ... Belongs to the class-I DAHP synthase family.Curated. Phylogenomic databases. evolutionary genealogy of genes: Non-supervised ... 3. EBI-1125143,EBI-543750. GO - Molecular functioni. *identical protein binding Source: EcoCycInferred from direct assayi* ...
more infohttps://www.uniprot.org/uniprot/P00887
Pseudomonas sRNA P15 - Wikipedia  Pseudomonas sRNA P15 - Wikipedia
P15 has a predicted Rho independent terminator at the 3' end but the function of P15 is unknown. Pseudomonas sRNA P1 ... P15 is conserved across several Pseudomonas species and is consistently located upstream of a 3-deoxy-7-phosphoheptulonate ... synthase gene. ...
more infohttps://en.wikipedia.org/wiki/Pseudomonas_sRNA_P15
KEGG SSDB Best Search Result: bfo:BRAFLDRAFT 126138  KEGG SSDB Best Search Result: bfo:BRAFLDRAFT 126138
egn:BMF35_a1970 CTP synthase K01937 545 102 ( -) 29 0.309 81 -, 1 fib:A6C57_11525 carbamoyl phosphate synthase small subu ... abam:B1s21122_03435 CTP synthase K01937 545 100 ( -) 29 0.326 92 -, 1 aep:AMC99_01220 CTP synthase K01937 544 100 ( -) 29 0.321 ... vmo:VMUT_0696 CTP synthase K01937 548 101 ( -) 29 0.347 75 -, 1 woc:BA177_01830 hypothetical protein 317 101 ( -) 29 0.317 82 ... hrb:Hrubri_2236 polyketide synthase 4172 115 ( -) 32 0.337 104 -, 1 orh:Ornrh_0096 putative N-acetylglucosamine kinase 287 115 ...
more infohttp://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=bfo:BRAFLDRAFT_126138
A chalcone synthase controls the verticillium disease resistance response in both Arabidopsis thaliana and cotton | Springer...  A chalcone synthase controls the verticillium disease resistance response in both Arabidopsis thaliana and cotton | Springer...
vsad1 is a previously identified allele of the transparent testa 4 gene (tt4), which encodes chalcone synthase (CHS), a key ... A chalcone synthase controls the verticillium disease resistance response in both Arabidopsis thaliana and cotton. ... Characterization and expression of chalcone synthase gene from Ginkgo biloba. Plant Science, 168, 1525-1531.CrossRefGoogle ... Enzymatic properties and mutational studies of chalcone synthase from Physcomitrella patens. International Journal of Molecular ...
more infohttps://rd.springer.com/article/10.1007%2Fs10658-018-1521-9
Seedless mutant Wuzi Ougan (Citrus suavissima Hort. ex Tanaka seedless) and the wild type were compared by iTRAQ-based...  Seedless mutant 'Wuzi Ougan' (Citrus suavissima Hort. ex Tanaka 'seedless') and the wild type were compared by iTRAQ-based...
CHS (chalcone synthase) and CHI (chalcone isomerase) are rate-limiting enzymes and involved in male sterility when their ... An anther-specific chalcone synthase-like gene D 5 related to rice pollen development. Chin Sci Bull. 2000;45(21):1921-6.View ... LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in ... Kehrel B, Wiermann R. Immunochemical localization of phenylalanine ammonia-lyase and chalcone synthase in anthers. Planta. 1985 ...
more infohttps://bmcgenet.biomedcentral.com/articles/10.1186/s12863-018-0693-9
Transcriptional profile of Paracoccidioides spp. in response to itraconazole | BMC Genomics | Full Text  Transcriptional profile of Paracoccidioides spp. in response to itraconazole | BMC Genomics | Full Text
Banks IR, Specht CA, Donlin MJ, Gerik KJ, Levitz SM, Lodge JK: A chitin synthase and its regulator protein are critical for ... These components are diacylglycerol o-acyltransferase (DGAT), chitin synthase regulator 2 (CHSr), hemolysin-iii channel protein ... HSP70 and ATP synthase f0 subunit 9 (ATPS9). These genes were chosen because of their high frequency or as representatives of ... as indicated by up-regulation of DGAT and phosphatidyl synthase (PHS), which produce phospholipids. DGAT has been found in ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-254
ccmO protein (Gloeobacter violaceus) - STRING interaction network  ccmO protein (Gloeobacter violaceus) - STRING interaction network
Other names: G. violaceus, G. violaceus PCC 7421, Gloeobacter, Gloeobacter violaceus, Gloeobacter violaceus ATCC 29082, Gloeobacter violaceus PCC 7421, Gloeobacter violaceus str. PCC 7421, Gloeobacter violaceus strain PCC 7421, Gloeobacterales, Gloeobacterales Cavalier-Smith 2002, Gloeobacteria, Gloeobacteria Cavalier-Smith 2002 ...
more infohttps://string-db.org/network/251221.gvip284
Network Portal - Gene GSU0247  Network Portal - Gene GSU0247
3-deoxy-7-phosphoheptulonate synthase (RefSeq). 3, 119. GSU3334. GSU3334. cytochrome c family protein, putative (NCBI). 3, 205 ... POSITION A C G T 1 0.8 0.0 0.2 0.0 2 0.2 0.0 0.0 0.8 3 0.0 0.8 0.0 0.2 4 1.0 0.0 0.0 0.0 5 0.2 0.0 0.8 0.0 6 0.0 1.0 0.0 0.0 7 ... POSITION A C G T 1 1.0 0.0 0.0 0.0 2 0.8 0.2 0.0 0.0 3 0.0 0.0 0.8 0.2 4 0.6 0.0 0.4 0.0 5 0.8 0.2 0.0 0.0 6 0.6 0.0 0.0 0.4 7 ... GSU0247 has total of 31 gene neighbors in modules 3, 119 name=Regulon neighbor genes. species=Geobacter sulfurreducens. ( ...
more infohttp://networks.systemsbiology.net/gsu/gene/GSU0247
Gene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane...  Gene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane...
ATP synthase type III secretion protein N [EC:3.6.3.14]) but in no other rumen bacteria.. ... 2013;7:316-21.View ArticlePubMedPubMed CentralGoogle Scholar. *. Bain WE, Bezuidenhout L, Jopson NB, Pinares-Patino C, McEwan ... 1975;64:540-3.View ArticlePubMedGoogle Scholar. *. Porschen RK, Chan P. Anaerobic vibrio-like organisms cultured from blood: ... 2007;23:3251-3.View ArticlePubMedGoogle Scholar. *. R Core Team. R: a language and environment for statistical computing. ...
more infohttps://0-bmcresnotes-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s13104-017-2671-0
Network Portal - Gene BSU03670  Network Portal - Gene BSU03670
POSITION A C G T 1 1.0 0.0 0.0 0.0 2 0.0 0.0 1.0 0.0 3 0.0 0.5 0.5 0.0 4 0.0 0.0 1.0 0.0 5 1.0 0.0 0.0 0.0 6 1.0 0.0 0.0 0.0 7 ... POSITION A C G T 1 0.0 1.0 0.0 0.0 2 0.0 0.0 1.0 0.0 3 1.0 0.0 0.0 0.0 4 0.0 0.0 1.0 0.0 5 0.0 1.0 0.0 0.0 6 0.0 0.0 1.0 0.0 ... bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase (RefSeq). 229, 315. BSU30310. ytwF. putative sulfur ... POSITION A C G T 1 0.0 1.0 0.0 0.0 2 0.0 1.0 0.0 0.0 3 0.0 0.333333 0.0 0.666667 4 0.0 1.0 0.0 0.0 5 0.0 0.333333 0.666667 0.0 ...
more infohttp://networks.systemsbiology.net/bsu/gene/BSU03670
SA1558 - AureoWiki  SA1558 - AureoWiki
pseudaminic acid synthase (TIGR03586; EC 2.5.1.97; HMM-score: 28.5) MetabolismAmino acid biosynthesisAromatic amino acid family ... Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) Chorismate mutase I (EC 5.4.99.5) / 2-keto-3- ... deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta (EC 2.5.1.54) ... product: bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. ⊟Genome View[edit source , edit]. Meta Function ...
more infohttp://aureowiki.med.uni-greifswald.de/SA1558
Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons | Proteome Science |...  Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons | Proteome Science |...
... whereas only the ATP synthase β-subunit was detected in the I-2 proteome. ATP synthase is a very large complex (,500 kDa) ... alpha-trehalose-phosphate synthase (UDP-forming, spot 17), granule-bound starch synthase 1 (spot 35), and ribulose-phosphate 3- ... alpha-trehalose-phosphate synthase (TPS4) (Q9T079_ARATH), APC2 (Q8H1U5_ARATH), 1-aminocyclopropane-1-carboxylate synthase 7 ( ... AdoMet synthase catalyzes the formation of AdoMet from methionine and ATP [34], which is the main methyl group donor and is ...
more infohttps://proteomesci.biomedcentral.com/articles/10.1186/1477-5956-9-26
SACOL RS05220 - AureoWiki  SACOL RS05220 - AureoWiki
cysteine synthase [1] (data from MRSA252). SACOL_RS02930. pyridoxal 5'-phosphate synthase lyase subunit PdxS [1] (data from ... GMP synthase (glutamine-hydrolyzing) [1] (data from MRSA252). SACOL_RS02640. YbaB/EbfC family nucleoid-associated protein [1] ( ... beta-ketoacyl-[acyl-carrier-protein] synthase II [1] (data from MRSA252). SACOL_RS05135. oligoendopeptidase F [1] (data from ... 1,4-dihydroxy-2-naphthoyl-CoA synthase [1] (data from MRSA252). SACOL_RS05470. bifunctional methylenetetrahydrofolate ...
more infohttp://aureowiki.med.uni-greifswald.de/SACOL_RS05220
Family Search for PF16473 (DUF5051)  Family Search for PF16473 (DUF5051)
3 LACT02396 Cas9/Csn1 0 0 0 1/1 1/1 0 0 0 1/1 0 3 3 LCRIS_01207 cas-CT1978 0 0 0 0 0 0 0 0 0 1/1 1 1 LCRIS_01209 casE-Cse3 0 0 ... STMUK_2027 3'-5' exoribonuclease from Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1. Aligns to 2:178 / 189 ... EXOD_BPT4 / P04536 Exodeoxyribonuclease; 3'-5' exonuclease; EC 3.1.11.1 from Enterobacteria phage T4 (Bacteriophage T4) (see 2 ... EXRBN_MYCTU / P9WJ73 3'-5' exoribonuclease Rv2179c; EC 3.1.13.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) ( ...
more infohttp://papers.genomics.lbl.gov/cgi-bin/hmmSearch.cgi?hmmId=PF16473
364 projects  364 projects
X-ray diffraction data for the Crystal structure of beta-ketoacyl-ACP synthase III (FabH) from Vibrio Cholerae in complex with ... X-ray diffraction data for the X-ray crystal structure of a putative UDP-4-amino-4-deoxy-l-arabinose--oxoglutarate ... X-ray diffraction data for the Crystal Structure of K170M Mutant of Type I 3-Dehydroquinate Dehydratase (aroD) from Salmonella ... X-ray diffraction data for the Crystal Structure of Type I 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium with ...
more infohttps://proteindiffraction.org/search/?show=100&q=beamline=21-ID-G
KEGG SSDB Best Search Result: bna:111207313  KEGG SSDB Best Search Result: bna:111207313
amm:AMES_0622 aminodehydroquinate synthase K16020 351 106 ( -) 30 0.341 91 -, 1 amn:RAM_03190 aminodehydroquinate synthase ... sho:SHJGH_3366 anthranilate/para-aminobenzoate synthase K13063 623 108 ( -) 30 0.302 172 -, 1 shy:SHJG_3601 anthranilate/para- ... sle:cxmG RifG homologue, AminoDHQ synthase, AHBA biosyn 368 104 ( -) 30 0.340 103 -, 1 spar:SPRG_14999 hypothetical protein 477 ... erb:A4V01_14610 argininosuccinate synthase K01940 407 104 ( -) 30 0.382 55 -, 1 gst:HW35_03220 3-methyl-2-oxobutanoate ...
more infohttps://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=bna:111207313
RCSB PDB 









- 1ZCO: Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase...  RCSB PDB - 1ZCO: Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase...
Substrate Ambiguity and Crystal Structure of Pyrococcus furiosus 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase: An ... Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. ...
more infohttp://www.rcsb.org/pdb/explore/derivedData.do?structureId=1ZCO
Pre GI: Gene  Pre GI: Gene
oxaloacetate decarboxylase gamma chain 3. QuickGO ontology. BLASTP. 878368. 880137. 1770. oxaloacetate decarboxylase alpha ...
more infohttp://pregi.bi.up.ac.za/pre_gi_gene.php?source_accession=NC_011083&gi_accession=NC_011083:862901
Pre GI: Gene  Pre GI: Gene
Tryptophan synthase. QuickGO ontology. BLASTP. 433717. 434529. 813. 3-deoxy-7-phosphoheptulonate synthase. QuickGO ontology. ... Indole-3-glycerol-phosphate synthase. QuickGO ontology. BLASTP. 430779. 431393. 615. Phosphoribosylanthranilate isomerase. ... tryptophan synthase beta chain. QuickGO ontology. BLASTP. 432826. 433605. 780. ...
more infohttp://pregi.bi.up.ac.za/pre_gi_gene.php?source_accession=NC_008346&gi_accession=NC_008346:410940
Category:CS1 errors: dates - wikidoc  Category:CS1 errors: dates - wikidoc
3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase. *3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA ...
more infohttps://www.wikidoc.org/index.php/Category:CS1_errors:_dates
List of EC numbers (EC 2) - Wikipedia  List of EC numbers (EC 2) - Wikipedia
... acetolactate synthase EC 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase EC 2.2.1.8: fluorothreonine transaldolase EC 2.2.1.9 ... synthase EC 2.3.3.2: decylcitrate synthase EC 2.3.3.3: citrate (Re)-synthase EC 2.3.3.4: decylhomocitrate synthase EC 2.3.3.5: ... synthase EC 2.4.1.12: cellulose synthase (UDP-forming) EC 2.4.1.13: sucrose synthase EC 2.4.1.14: sucrose-phosphate synthase EC ... squalene synthase EC 2.5.1.22: spermine synthase EC 2.5.1.23: sym-norspermidine synthase EC 2.5.1.24: discadenine synthase EC ...
more infohttps://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_2)
ENZYME: 2.-.-.  ENZYME: 2.-.-.
Acetolactate synthase 2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.8 Fluorothreonine transaldolase 2.2.1.9 2-succinyl- ... synthase 2.4.1.12 Cellulose synthase (UDP-forming) 2.4.1.13 Sucrose synthase 2.4.1.14 Sucrose-phosphate synthase 2.4.1.15 Alpha ... Squalene synthase 2.5.1.22 Spermine synthase 2.5.1.23 Sym-norspermidine synthase 2.5.1.24 Discadenine synthase 2.5.1.25 tRNA- ... synthase 2.3.3.2 Decylcitrate synthase 2.3.3.3 Citrate (Re)-synthase 2.3.3.4 Decylhomocitrate synthase 2.3.3.5 2-methylcitrate ...
more infohttps://enzyme.expasy.org/EC/2.-.-.-
Shikimate biosynthesis | LAMP  Shikimate biosynthesis | LAMP
Bifunctional aminodeoxy-chorismate synthase/Anthranilate synthase. 2.6.1.85; 4.1.3.27. TGME49_202920. ... Sulfonamide, a component of anti-malarial drug Fansidar competes with PABA for dihydropteroate synthase and the dihydropteroate ... gondii extracts and the enzyme chorimsate synthase was cloned from both P. falciparum and T. gondii. ... anologue synthesised from sulfonamide is toxic and inhibits dihydrofolate synthase enzyme. The comparison of sulfonamide- ...
more infohttp://www.llamp.net/?q=Shikimate%20biosynthesis
  • Structure of Aquifex aeolicus kdo8ps in complex with z-methyl-pep 2-dehydro-3-deoxyphosphooctonate aldolase. (wikipedia.org)
  • [3] This method is also found in bacteria, but feedback inhibition is more prevalent. (wikipedia.org)