4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridinone. Analog of uridine lacking a ring-nitrogen in the 3-position. Functions as an antineoplastic agent.
An experimental lymphocytic leukemia of mice.

Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. (1/16)

 (+info)

Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia. (2/16)

Pyrazofurin (NSC 143095) as the monophosphate derivative is a potent inhibitor of orotidine 5'-monophosphate (OMP) decarboxylase of the pyrimidine pathway and has been proposed to inhibit 5-aminoimidazole-4-carboxamide ribotide (AICAR) transformylase (EC 2.1.2.3) of the purine pathway (J. F. Worzalla, and M. J. Sweeney, Pyrazofurin inhibition of purine biosynthesis via 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate formyltransferase. Cancer Res., 40: 1482-1485, 1980). Measurement of levels of pyrimidine and purine intermediates in cultured mouse L1210 leukemia cells has shown that 25 microM pyrazofurin induces an 8-fold accumulation of OMP and large accumulations of intermediates proximal to the blockade with abrupt decreases in uridine and cytidine nucleotides. Considerable increases in the cellular concentrations of N-succino-AICAR (SAICAR), AICAR, 5-formamidoimidazole-4-carboxamide ribotide (FAICAR), IMP, XMP, and GMP at later times indicate that AICAR transformylase is not significantly inhibited in cultured cells; rather the purine pathway and the GMP branch are stimulated. However, addition of 25 microM 3-deazauridine (NSC 126849) to leukemia cells did result in inhibition of AICAR transformylase: AICAR and SAICAR accumulated, IMP disappeared and there was a large accumulation of guanosine nucleotides. Blockade of pyrimidine biosynthesis by derivatives of pyrazofurin or 3-deazauridine spares 5-phosphoribosyl-1-pyrophosphate and L-glutamine, elevated concentrations of which may stimulate initial reactions of purine biosynthesis and the reaction XMP----GMP.  (+info)

Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in cultured human leukemic RPMI 6410 cells. (3/16)

When incubated with 1-beta-D-arabinofuranosylcytosine (ara-C), RPMI 6410 cells formed a hitherto unrecognized ara-C metabolite, 1-beta-D-arabinofuranosylcytosine diphosphate choline. This compound was characterized by (a) chromatographic behavior, (b) chemical and enzymatic hydrolysis, (c) phosphorus content, and (d) incorporation of [5-3H]ara-C and [methyl-14C]choline. Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline by RPMI 6410 cells was enhanced in the presence of 3-deazauridine (DU) and was preceded by that of 1-beta-D-arabinofuranosylcytosine triphosphate. The antiproliferative effects of ara-C and DU toward RPMI 6410 cells were potentiated when the agents were present together. The anabolism of ara-C during a 24-hr interval of culture was markedly enhanced by the presence of DU; cellular concentrations of 1-beta-D-arabinofuranosylcytosine triphosphate and 1-beta-D-arabinofuranosylcytosine diphosphate choline were 5- and 15-fold higher than those in the absence of DU. This enhancement appears to be the basis of the potentiation of cytotoxicity resulting from combination of the agents. Pretreatment of RPMI 6410 cells with DU resulted in enhanced rates of cellular uptake of ara-C. ara-C uptake under these circumstances was blocked by the inhibitor of nucleoside transport, nitrobenzylthioinosine.  (+info)

Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in neoplastic and normal cells. (4/16)

1-beta-D-Arabinofuranosylcytosine diphosphate choline was formed from 1-beta-D-arabinofuranosylcytosine (ara-C) during incubation in vitro of peripheral myeloblasts from patients with acute myelogenous leukemia and cultured cells (nonleukemic human lymphocytes, mouse lymphoma L5178Y, and HeLa); as well, 1-beta-D-arabinofuranosylcytosine diphosphate choline was formed in vivo in mouse leukemia L1210 cells and mouse liver. 3-Deazauridine enhanced the anabolism of ara-C in nonleukemic lymphocytes in vitro and leukemia L1210 cells in vivo but did not influence ara-C anabolism in the other cell types. In acute myelogenous leukemia myeloblasts incubated in vitro with ara-C, concentrations of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate were maximal after 8 hr of incubation and formation of the latter preceded that of 1-beta-D-arabinofuranosylcytosine diphosphate choline.  (+info)

Effects of pyrimidine antagonists on sialic acid regeneration in HL-60 cells. (5/16)

Because alterations in cell membrane sialoglycoconjugates can affect the behavior of neoplastic cells, we investigated the effects of in vitro treatment with antimetabolites used in cancer therapy on the expression of membrane sialic acid in cultured HL-60 leukemic cells. In these studies, cells were incubated with Vibrio cholerae neuraminidase to remove surface sialic acid. Reappearance of membrane sialic acid during drug treatment was followed (a) by measuring changes in radioactive surface labeling of viable cells with sodium metaperiodate-sodium[3H]-borohydride, (b) by measuring the decline in accessible surface galactosyl receptor sites which occurred coincident with membrane sialic acid replacement, and (c) by measuring the incorporation of [3H]glucosamine into membrane-associated neuraminidase-labile sialic acid. We were especially interested in learning whether drugs that affect intracellular pools of cytidine triphosphate (CTP), an important nucleotide intermediate in sialylation reactions, could inhibit regeneration of membrane sialic acid. 3-Deazauridine, a competitive inhibitor of CTP synthetase, depleted CTP pools and curtailed surface membrane resialylation with little or no effect on synthesis of de novo sialic acid from precursor sugars. The addition of cytidine restored CTP pools and sialic acid regeneration. Acivicin, a glutamine antagonist, also depleted CTP pools and curtailed surface membrane resialylation. In addition, it retarded de novo synthesis of sialic acid. The addition of cytidine restored intracellular CTP pools and sialic acid regeneration. However, both cytidine and guanosine were required to restore sialic acid synthesis from precursor sugars. 1-beta-D-Arabinofuranosylcytosine, a competitive inhibitor of sialic acid synthetase and of sialyltransferase, inhibited both de novo sialic acid synthesis and membrane resialylation. Only the latter effect was reversed by the addition of exogenous cytidine. Hydroxyurea, an agent shown previously to inhibit glycoconjugate production in hamster fibroblasts, curtailed membrane resialylation and de novo synthesis of sialic acid without depleting CTP pools. Doxorubicin, at levels that caused marked arrest of cell proliferation, had no effect on sialic acid synthesis or expression on the membrane surface. These data suggest that antimetabolites, apart from their cytotoxic effects or effects on cellular growth, may directly inhibit the expression of membrane sialic acid.(ABSTRACT TRUNCATED AT 400 WORDS)  (+info)

Drug sequence-dependent toxicity and small bowel mucosal injury in mice treated with low doses of 3-deazauridine and 1-beta-D-arabinofuranosylcytosine. (6/16)

The toxicity to mice of combinations of 1-beta-D-arabinofuranosylcytosine and 3-deazauridine was investigated. The drugs were administered daily i.p. on Days 1 to 5, each drug at 10 mg/kg body weight; these dosages are small fractions of the dosages at which 10% of the treated animals died when either drug was administered alone on the foregoing schedule. This drug combination was severely toxic when 3-deazauridine was administered 2 to 8 hr prior to 1-beta-D-arabinofuranosylcytosine; most mice treated in this way died within 3 days of the last treatment. Histological examination showed that severe damage to the small bowel mucosa resulted from treatment with the drugs in the above, lethal sequence. In contrast, treatments with this drug combination at the same dosages were tolerated when the two agents were administered simultaneously or when 1-beta-D-arabinofuranosylcytosine preceded 3-deazauridine. Under the latter conditions, small bowel mucosal injury was much less severe. Female mice were more sensitive to the toxic treatment regimen than were male mice and were protected against the latter when either the 3-deazauridine or the 1-beta-D-arabinofuranosylcytosine component was preceded by treatment with nitrobenzylthioinosine (100 mg/kg), a potent inhibitor of nucleoside transport.  (+info)

Synergistic action of 5-aza-2'-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells. (7/16)

The biochemical and biological effects of the combination of 5-aza-2'-deoxycytidine (5-aza-dCyd) and 3-deazauridine (3-DU) on L1210 leukemic cells and EMT6 tumor cells were investigated. The cytotoxic action of 5-aza-dCyd and 3-DU on both L1210 and EMT6 cells in vitro was synergistic when these agents were used in combination. The combination of 5-aza-dCyd and 3-DU produced a greater inhibition of in vitro growth of L1210 and EMT6 cells than did either agent alone. The in vivo antineoplastic activity of this combination was synergistic with respect to the increased survival time of BALB/c x DBA/2 F1 mice with L1210 leukemia. 3-DU, an agent that reduces the intracellular pool size of cytosine nucleotides, stimulated the incorporation of [3H]-5-aza-dCyd into DNA of both L1210 and EMT6 cells, suggesting that the synergistic action of this combination is related to the increased incorporation of 5-aza-dCyd in the presence of 3-DU.  (+info)

Penetration of 3-deazauridine into human brain, intracerebral tumor, and cerebrospinal fluid. (8/16)

The antitumor agent 3-deazauridine (DAU) was administered rapidly to four patients before surgical removal of intracerebral tumor. Tumor, adjacent brain tissue, and temporalis muscle were assayed for DAU by high-pressure liquid chromatography. DAU penetrated comparably into tumor, brain, and muscle; in one patient, tissue concentrations were higher than concurrent plasma concentrations. The active metabolite 3-deazauridine 5'-triphosphate was quantitated in one tumor sample and greatly exceeded its Ki for cytidine 5'-triphosphate synthetase. DAU was also present in autopsy brain specimens from two patients treated shortly antemortem. Cerebrospinal fluid concentrations were 22.1 and 59.0%, respectively, of concurrent plasma concentrations during continuous infusion of DAU in two patients. Cerebrospinal fluid concentration was 3.1 microgram/ml 2 hr after a 30-min infusion of 1.5 g of drug per sq m and fell to 1.9 microgram/ml at 16 hr. Thus, DAU is capable of penetrating into intracerebral tumor, brain, and cerebrospinal fluid and is worthy of investigation in the treatment of intracerebral and meningeal neoplasms.  (+info)

TY - JOUR. T1 - Effect of Uridine on Response of 5-Azacytidine-resistant Human Leukemic Cells to Inhibitors of de Novo Pyrimidine Synthesis. AU - Grant, S.. AU - Bhalla, K.. AU - Gleyzer, M.. PY - 1984/12/1. Y1 - 1984/12/1. N2 - A uridine-cytidine kinase-deficient human promyelocytic leukemic subline (HL-60-5-aza-Cyd) has been isolated which is highly resistant to the antileukemic agent 5-azacytidine. Resistant cells exposed to 10-5 M 5-azacytidine for 2 hr exhibit a marked reduction in both the total intracellular accumulation of 5-azacytidine (11.9 versus 156.0 pmol/106 cells) as well as its incorporation into RNA (3.1 versus 43.4 pmol/μg D-ribose) compared to the parent line. These biochemical changes are associated with nearly a 100-fold decrease in sensitivity to the growth inhibitory effects of 5-azacytidine (concentration of drug associated with a 50% reduction in cell growth, 3.5 x 10-5 versus 5.0 x 10-7 M). 5-Azacytidine-resistant cells exhibit cross-resistance to 3-deazauridine, ...
Define Antimetabolic agent. Antimetabolic agent synonyms, Antimetabolic agent pronunciation, Antimetabolic agent translation, English dictionary definition of Antimetabolic agent. n. A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite. an′ti·met′a·bol′ic...
Synonyms for Antimetabolic agent in Free Thesaurus. Antonyms for Antimetabolic agent. 9 words related to antimetabolite: antineoplastic, antineoplastic drug, cancer drug, fluorouracil, mercaptopurine, Purinethol, amethopterin, methotrexate.... What are synonyms for Antimetabolic agent?
Mouse monoclonal antibody raised against native NCAM1. Native purified NCAM1 from KG-1 human acute myelogenous leukemia cell line. (MAB5003) - Products - Abnova
=------------------------------------------------------------------------------- Corporate news transmitted by euro adhoc with the aim of a Europe-wide distribution. The issuer is responsible... | June 14, 2021
Nutrient limitation occurs during physiological tissue growth or as a consequence of various pathological events, such as wounds or vascular occlusions that lead to transient ischemia. To recover, ischemic tissues employ mechanisms that promote wound healing and the restoration of the nutrient flux. These mechanisms include angiogenesis and inflammation, which have been classically attributed to hypoxia or to necrotic inflammatory signals, respectively. We show here that nutrient deprivation could be, by itself, a powerful signal to induce inflammation as part of a normal wound-healing response as pathogens and sterile injuries trigger similar events which include the recruitment of the innate immune system. It is possible that nutrient deprivation followed by the ISR is one of the many signals that the body uses to detect infections as pathogens also deprive nutrients from the site of infection. In fact, the kinase PKR, that detects viral dsRNA, is one of the kinases that activate the ISR ...
This youth enhancing Vita-Peptide Eye Gel contains essential vitamins & antioxidants as well as specially selected peptides plus hyaluronic acid regeneration technology. It assists in reducing the visible signs of ageing, promoting a youthful luminous, smooth and plumped appearance. BENEFITS FOR YOUR SKIN Contains
Youth EssentiA Vita-Peptide Eye Gel is a new scientifically advanced formulation which intelligently combines a highly specialized system of essential vitamins (A,C & E), antioxidants, peptides, and a new hyaluronic acid regeneration technology, Optim-Hyal™. This light weight eye gel assists in restoring the benefi
Buy Renor Online! Renor is a white to pale yellow crystalline powder with a molecular weight of 319.34 and a melting point of about 221°C. Renor, a fluoroquinolone, differs from non-fluorinated quinolones by having a fluorine atom at the 6 position and a piperazine moiety at the 7 position.
This is a third-party research done by a grant from YuFoundation for Tom Seyfried to research Dr. Young Kos 3 Bromopyruvate antimetabolic drug used in cancers. The important outcome is when 3 BP was injected into the primary cancer site, the metastatic rate was impressively low. Therefore, spread of the cancers may be hindered with this molecule. Please read more in section under grants and scientific information.. ...
This rule sets national emission standards for hazardous air pollutants (NESHAP) for hydrochloric acid (HCI) process steel pickling facilities and hydrochloric acid regeneration plants pursuant to section 112 of the Clean Air Act (Act).. Pickling is a process in which an acid solution is used to remove oxide scale from steel strip, rod, wire, tubing, and discreet shapes. Oxide scale forms on the surface of the steel when steel cools from a molten state. The steel pickling facilities that are affected by this rule use a solution of hydrochloric acid (HCl) to remove the oxide scale.. This process emits HCI, a hazardous air pollutant (HAP). Chronic exposure to HCl has been reported to cause gastritis, chronic bronchitis, dermatitis, and photosensitization. Acute inhalation exposure to HCl may cause hoarseness, inflammation and ulceration of the respiratory tract, chest pain, and pulmonary edema. Hydrochloric acid regeneration plants also emit chlorine (Cl2), which is also a HAP. Acute exposure to ...
ANDRITZ METALS supplies complete lines for the production and further processing of cold-rolled strip from carbon steel, stainless steel and non-ferrous metals, as well as industrial furnaces. In plants for production of stainless steel strip, acid regeneration, electrolytic galvanizing and push pickling lines we lead the world market.
CDP-choline stands for cytidine-5Í-diphosphate choline. This unique form of choline readily passes through the blood-brain barrier (BBB) directly into the brain tissue. Once past the blood-brain barrier, CDP-choline activates the synthesis of critical components in cell membranes, enhances cerebral energy metabolism and increases levels of various neurotransmitters.. Supplement ...
Definition of cytidine diphosphate choline. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Baker, Lindsey A., Tiriac, Hervé, Clevers, Hans, Tuveson, David A. (April 2016) Modeling Pancreatic Cancer with Organoids. Trends in Cancer, 2 (4). pp. 176-190. ISSN 2405-8033 Bapiro, T. E., Frese, K. K., Courtin, A., Bramhall, J. L., Madhu, B., Cook, N., Neesse, A., Griffiths, J. R., Tuveson, D. A., Jodrell, D. I., Richards, F. M. (May 2014) Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo. British Journal of Cancer, 111 (2). pp. 318-325. ISSN 0007-0920 Bergerson, R. J., Collier, L. S., Sarver, A. L., Been, R. A., Lugthart, S., Diers, M. D., Zuber, J., Rappaport, A. R., Nixon, M. J., Silverstein, K. A. T., Fan, D. H., Lamblin, A. F. J., Wolff, L., Kersey, J. H., Delwel, R., Lowe, S. W., OSullivan, M. G., Kogan, S. C., Adams, D. J., Largaespada, D. A. (May 2012) An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood, 119 (19). pp. 4512-4523. ISSN 0006-4971 Boj, ...
Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. Positive clinical results were suggested to result from rapid and effective DNA-crosslinking following uptake in neoplastic cells, but also from antimetabolic properties of the drug. Although m-L-sarcolysin never reached widespread clinical use, the well established para-isomer melphalan still, after nearly fifty years, has a place in cancer chemotherapy.. The present study was undertaken to synthesise the melphalan containing analogue of the tripeptide P2 (L-prolyl-m-L-sarcolysyl-p-L-fluorophenylalanine ethyl ester, the main contributor to Peptichemios activity) and similar compounds, preferably dipeptides. The new compounds compared favourably with melphalan, m-L-sarcolysin ...
DAU provides the Acquisition, Technology, and Logistics (AT&L) workforce training. All Service and DoD employees may attend DAU classes. Non-DoD federal agency and defense industry employees may attend DAU courses at no cost on a space available basis.
In the compound sodium flouride, NaF, the sodium atom loses one electron and the fluorine atom gains one electron to form ions that have electron configurations similar to _____. ...
Senescence Effects of Angelica sinensis Polysaccharides on Human Acute Myelogenous Leukemia Stem and Progenitor Cells Angelica sinensis polysaccharide;leukemia stem/progenitor cells;senescence;telomerase;telomere; Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression and relapse, and thus represent a critical target for therapeutic intervention. Hence, it is extremely urgent to explore new therapeutic strategies directly targeting LSCs for acute myelogenous leukemia (AML) therapy. We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML $CD34^+CD38^-$ cell proliferation in vitro culture in a dose-dependent manner while sparing normal hematopoietic stem and progenitor cells at physiologically achievable concentrations. Furthermore, ASP exerted cytotoxic effects on AML K562 cells, especially LSC-enriched $CD34^+CD38^-$ cells. Colony formation assays further showed that ASP
NioCorp $NB $NIOBF $BR3 #Niobium #Scandium #ElkCreek. About NioCorp. NioCorp is developing a superalloy materials project in Southeast Nebraska that will produce Niobium, Scandium, and Titanium. Niobium is used to produce superalloys as well as High Strength, Low Alloy (HSLA) steel, which is a lighter, stronger steel used in automotive, structural, and pipeline applications. Scandium is a superalloy material that can be combined with Aluminum to make alloys with increased strength and improved corrosion resistance. Scandium also is a critical component of advanced solid oxide fuel cells. Titanium is used in various superalloys and is a key component of pigments used in paper, paint and plastics and is also used for aerospace applications, armor and medical implants.. Cautionary Note Regarding Forward-Looking Statements Neither TSX nor its Regulation Services Provider (as that term is defined in the policies of the TSX) accepts responsibility for the adequacy or accuracy of this document. ...
0123] On the other hand, a monomer having fluorine at its ester moiety is an acrylic acid ester or methacrylic acid ester having a unit where the ester moiety is a perfluoroalkyl group or a fluoroalkyl group serving as a flurine-containing group or a unit having both a cyclic structure and a fluorine atom at a-position, the cyclic structure being a fluorine-containing benzene ring, fluorine-containing cyclopentane ring, fluorine-containing cyclohexane ring or fluorine-containing cycloheptane ring or the like in which substitution with a fluorine atom, trifluoromethyl group, hexafluoroisopropyl hydroxyl group or the like has been made. It is also possible to use an acrylic acid or methacrylic acid ester having a fluorine-containing t-butyl ester group at ester moiety. It is also possible to use monomers in which these fluorine-containing functional groups are used in combination with a fluorine-containing alkyl group of a-position. Of such units, as particularly typical ones are exemplarily ...
For regeneration of pickling acids in your steel mill, the PYROMARS (mixed acid regeneration) plant from ANDRITZ METALS is an efficient and effective solution. The high recovery rates of 99% hydrofluoric acid, 80% nitric acid, and 99% metals need no further comment.
Norm Lieberman has been a process engineer for 50 years. His first employment was with AMOCO Oil as a process design engineer. He worked at Texas City as an operating superintendent of alkylation, sulfuric acid regeneration, and mercaptan extraction. Norm has designed: • Sulfur Plants • Amine Regenerators • Delayed Cokers • Crude Units • Vacuum Towers Hes the author of several well known troubleshooting books: • A Working Guide to Process Equipment • Process Design for Reliable Operations • Troubleshooting Natural Gas Processing • Troubleshooting Process Operations • Troubleshooting Process Plant Control • Process Engineering for a Small Planet • Process Equipment Malfunctions • Troubleshooting Vacuum Systems • My Race Against Death He has instructed 820 process troubleshooting seminars, attended by over 19,000 engineers and experienced operators since 1983. Mr. Lieberman is still actively involved in field troubleshooting and instructing process seminars. In 2015, ...
60 Vegetarian capsules Optimize Your Brain Function * Enhances memory in the elderly * Supports balanced mood and cognitive function * Promotes phospholipid balance in the brain and enhances neurotransmitter production * Clinically shown to aid in recovery from traumatic brain injury Citicoline is cytidine diphosphate choline, or CDP-choline, a nutrient that has been shown to support memory in patients with age-associated memory impairment, and brain cell recovery from injuries such as stroke or concussion. Citicoline also increases the production of key neurotransmitters, including acetylcholine, norepinephrine, dopamine, and serotonin, all of which are essential for mood balance and memory. Additionally, it supports nerves in the eye, and studies administering Citicoline to patients with lazy-eye and other vision disorders have noted beneficial results. The main component of Citicoline is its cytidine group, which is what Citicoline delivers to
Mizantropii dau bine pe ecran . Dintotdeauna. E logic. Il vezi pe unul care injura tot si toate si empatizezi, purtat de micile tale frustrari ...
Okabayashi, T; Mihara, S; Repke, D B.; and Moffatt, J G., A radioimmunoassay for 1-beta-d-arabinofuranosylcytosine. (1977). Subject Strain Bibliography 1977. 1646 ...
The molecule has the configuration of a trigonal bipyramid as predicted by the VSEPR model Two of the fluorine atoms designated as axial are aligned with the phosphorus atom with PF bond distances of 158 Aring The remaining three fluorine atoms designated as equatorial are arranged in an equilateral triangle with PF bond distances of 153 Aring Even though there exist two geometrically inequivalent
Bună sara! Ne-am mutat la casâ nouâ șî am zâs câ ar fi ghini sâ vă cinstesc oleacă! Am pentru voi o sacoșâ cu dulșiuri șî niști bieri. Aș fi vrut sâ vă dau o tavâ cu poale-n brâu șî Continue reading Bre, dam premii pi digeaba!→. ...
Bună sara! Ne-am mutat la casâ nouâ șî am zâs câ ar fi ghini sâ vă cinstesc oleacă! Am pentru voi o sacoșâ cu dulșiuri șî niști bieri. Aș fi vrut sâ vă dau o tavâ cu poale-n brâu șî Continue reading Bre, dam premii pi digeaba!→. ...
Colorado Tick Fever. In: Hay, Jr WW, Levin MJ, Deterding RR, Abzug MJ. Hay, Jr W.W., Levin M.J., Deterding R.R., Abzug M.J. Eds. William W. Hay, Jr, et al.eds. Quick Medical Diagnosis & Treatment Pediatrics New York, NY: McGraw-Hill; . http://accesspediatrics.mhmedical.com/content.aspx?bookid=2196§ionid=166956538. Accessed January 20, 2018 ...
TY - CHAP. T1 - Tissue distribution and intracerebral tumor penetration of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZO, NSC 182986) in man. AU - Savaraj, Niramol. AU - Lu, K.. AU - Stewart, D.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=17544399898&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=17544399898&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:17544399898. VL - Vol. 22. BT - Proceedings of the American Association for Cancer Research. ER - ...
TY - JOUR. T1 - Dendritic cells derived in vitro from acute myelogenous leukemia cells stimulate autologous, antileukemic T-cell responses. AU - Choudhury, A.. AU - Liang, J. C.. AU - Thomas, E. K.. AU - Flores-Romo, L.. AU - Xie, O. S.. AU - Agusala, K.. AU - Sutaria, S.. AU - Sinha, I.. AU - Champlin, R. E.. AU - Claxton, D. F.. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 1999/2/1. Y1 - 1999/2/1. N2 - We have previously reported that leukemic dendritic cells (DC) can be generated ex vivo from myelomonocytic precursors in chronic myelogenous leukemia. In this study we report the generation of DC from acute mye1ogenous leukemia (AML) cells and their potent ability to stimulate leukemia-specific cytolytic activity in autologous lymphocytes. DC were generated in vitro using granulocyte-macrophage colony-stimulating factor+interleukin-4 in combination with either tumor necrosis factor-α or CD40 ligand (CD40L). Cells from 19 AML patients with a variety of chromosomal ...
This chapter discusses the de novo pathway of pyrimidine nucleotide biosynthesis. Animals do not have a dietary requirement for pyrimidines, and many microorgan
A team of MIT chemists has devised a new way to add fluorine to a variety of compounds used in many drugs and agricultural chemicals, an advance that could offer more flexibility and potential cost-savings in designing new drugs.. Drug developers commonly add fluorine atoms to drugs, such as the cholesterol-lowering rosuvastatin, to keep the body from breaking them down too quickly. Many of these drugs contain aromatic rings - a type of six-carbon ring - and attaching a fluorine atom to the rings can be a difficult, expensive process.. Its hard to add fluorine at a late stage, once you have a complete molecule already put together, because traditional methods can be quite harsh with respect to temperature or other factors, says Stephen L. Buchwald, the Camille Dreyfus Professor of Chemistry at MIT.. In their new technique, Buchwald and his colleagues used a palladium catalyst to attach a fluorine atom to aromatic compounds. The technique could be used in the design and testing of new drugs, ...
Recently much attention has been devoted to crystals containing organic ions and inorganic ions due to the possibility of tuning their special structural features and their potential ferroelectrics properties (Fu et al., 2011; Zhang et al., 2010.).. The compound (C4H12O3N)+(C2F3O2)- has an asymmetric unit that consists of one tris(hydroxymethyl)methanaminium cation and one trifluoroacetate anion (Fig 1). N-H···O and O-H···O hydrogen bonds form a complex three-dimensional network, (Fig 2). The trifluoromethyl group is quite mobile, but examination of a difference map in the plane of the fluorine atoms does show that the fluorine atoms exist as three distinct atoms.. For structure of the related tris(hydroxymethyl)methanaminium hydrogenhalides seen (Rudman et al., 1983).. ...
2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug.[1] 2-Fluoroamphetamine differs from 3- and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood-brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by the substitute.[2][3] ...
The bonding within dioxygen difluoride has been the subject of considerable speculation over the years, particularly because of the very short O-O distance and the long O-F distances. Bridgeman has proposed a scheme which essentially has an O-O triple bond and an O-F single bond that is destabilised and lengthened by repulsion between the lone pairs on the fluorine atoms and the π-orbitals of the O-O bond.[3] Repulsion involving the fluorine lone pairs is also responsible for the long and weak covalent bonding in the fluorine molecule.. ...
Colorado tick fever virus ATCC ® VR-1233CAF™ Designation: Colorado tick fever control ascitic fluid [V-506-401-562] Application:
TY - JOUR. T1 - Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood-brain barrier disruption. AU - Nilaver, Gajanan. AU - Muldoon, Leslie L.. AU - Kroll, Robert A.. AU - Pagel, Michael A.. AU - Breakefield, Xandra O.. AU - Davidson, Beverly L.. AU - Neuwelt, Edward A.. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1995/10/10. Y1 - 1995/10/10. N2 - The delivery of viral vectors to the brain for treatment of intracerebral tumors is most commonly accomplished by stereotaxic inoculation directly into the tumor. However, the small volume of distribution by inoculation may limit the efficacy of vital therapy of large or disseminated tumors. We have investigated mechanisms to increase vector delivery to intracerebral xenografts of human LX-1 small-cell lung carcinoma tumors in the nude rat. The distribution of Escherichia coli lacZ transgene expression from primary viral infection was assessed after delivery of recombinant virus by ...
Results of the present study show for the first time that Chk1 undergoes activating phosphorylation in marrow blasts in vivo during cytarabine-containing induction therapy. Building on this result, we also show in human AML cell lines that the selective Chk1 inhibitor SCH 900776 abrogates cytarabine-induced S-phase arrest, increases cytarabine-induced apoptosis, and enhances the effects of cytarabine on colony formation. Likewise, SCH 900776 increases the effects of cytarabine in a majority of primary AML isolates but not normal myeloid progenitors in vitro. This sensitization was observed at SCH 900776 concentrations far below the approximate 5 μmol/L SCH 900776 peak levels observed at the maximum tolerated dose in solid tumor patients. These observations have potentially important implications for current efforts to enhance the efficacy of cytarabine-containing AML regimens.. Previous results have shown that cytarabine activates the ATR/Chk1 checkpoint in tissue culture cell lines in vitro ...
http://www.wisegeek.com/what-is-nucleotide-biosynthesis.htm Nucleotide biosynthesis is the process whereby nucleotides are created or synthesized. This process
The idea of ​​anabolism refers to a series of metabolism processes that involve the synthesis of different complex molecules through other molecules of greater simplicity. Anabolism, in this way, consists in the synthesis of certain biomolecules from molecules that, in comparison, are simpler.
Uongozi wa Manchester United umeamua kufanya kweli baada ya kutangaza kumuongezea mkataba wa miaka mitano kocha wake, Jose Mourinho kwa dau la Paui 65
Colorado tick fever (CTF) is a disease caused by an RNA virus, Colorado tick fever virus (CTFV). Symptoms, which are often non-specific, begin 3 to 5 days after the bite with an abrupt onset of fever and any of these: headaches, chills, malaise, photophobia, myalgias, nausea, vomiting, diarrhea and abdominal pain. In 5 to 15% of cases a rash occurs. Neurologic complications may also occur. 50% of patients have single recurrence of fever (saddleback fever).. IFA titers for diagnosis. PCR (Polymerase Chain Reaction) is the test most often used to diagnose the disease. CTF is transmitted by Dermacentor andersoni (Rocky Mt. wood tick) which causes illness from the Western Black Hills to the West Coast in the USA. Some cases of transmission through blood transfusion have been reported. Treatment consists of supportive care.. ©LDA. 2014. 2015. This web site provides practical and useful information on the subject matters covered. It is distributed with the understanding that LDA is not engaged in ...
Abstract Isolation of the virus, the most reliable means of diagnosing Colorado tick fever, is not always practicable. The standard complement-fixation test, using a mouse-brain-derived antigen, may not detect significant rises in antibody titer during the usual 2- or 3-week observation period. Complement-fixation (CF) tests, with antigens derived from infected mouse brains and from an established line of hamster-kidney cells, were compared with a neutralization (plaque-reduction) test and an indirect fluorescent-antibody (IFA) staining test for usefulness in the serologic diagnosis of 34 cases of Colorado tick fever. The cell-culture antigen was as reliable as the mouse-brain antigen, and its preparation was simpler. The CF-antibody titers and the neutralizing-antibody titers tended to be lower and slower to appear than the IFA titers. The IFA method was simple, rapid, and accurate. The IFA titers frequently appeared earlier after onset of illness and reached higher levels than did the CF titers.
Learn more about Colorado Tick Fever at Atlanta Outpatient Surgery Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
The Japanese B Encephalitis Vaccination is available at our clinic to protect you on your travels. Call us on 01256 354981 to make an appointment.
In a new paper, Partha Bera and colleagues at NASAs Ames Research Center and Purdue University put these gases under the microscope to find out exactly why they are such powerful heat trappers. They focus on CFCs, HFCs and PFCs - all chemicals containing fluorine or chlorine - that are used in medicine, fridges, and as solvents, among other things. By probing the molecular structure of these compounds, they have found that molecules containing several fluorine atoms are especially strong greenhouse gases, for two reasons. First, unlike many other atmospheric molecules, they can absorb radiation that makes it through our atmosphere from space. Second, they absorb the radiation (and trap the heat) very efficiently, because of the nature of the fluorine bonds inside them. (In technical terms, fluorine atoms create a larger separation of electric charge within the molecule, and this helps the molecular bonds absorb electromagnetic radiation more effectively.) HFCs and other fluorine-based gases ...
Another name for Mediterranean Tick Fever is Boutonneuse Fever. Physicians from the following specialties evaluate and treat boutonneuse fever: * Infectious ...
When Fausto was found, he was running desoriented in the middle of the road among the cars, very thin and covered with wounds that did not seem to be healing. We took him to the vet who did the snap blood tests and it resulted that he had a tick fever and a suspicion of leshmaniasis. When a dog has a tick fever, the leshmaniasis test is very often inconclusive - neither positive nor negative but suspected. The tick fever influences the results so it is advisable to cure the tick fever first and then repeat the leshmaniasis test. So we did ...
Fluorocarbon polymer, any of a number of organic polymers whose large, multiple-unit molecules consist of a chain of carbon atoms to which fluorine atoms are appended. Owing to the presence of the highly polar fluorine atoms, which form extremely strong bonds with the carbon chain and resist
I am not sure whether (1) the dopant fluorine atoms group pairwise at iron atoms and (2) if the decorated iron atoms indeed form a superlattice. However, this may be checked experimentally. But then, (3), if there is a superlattice, it is not clear to me why it should be ordered in the way claimed in the paper, with a pattern stacking five unit cells on top of each other for COFFA, for example. There can be many ways to arrange unit cells to form a superlattice with the right supercell volume. This is more obvious in the case of LOFFA, where the supercell comprises 18 unit cells, and there seems to be no a priori reason to select a superstructure which has 6 unit cells stacked on top of each other ...
Perfluorotetracyclobuteno-1,3,5,7-cyclooctatetraene (PCOT) is a planar and centrosymmetric molecule which possesses an extraordinary electron affinity due to the planarity of the eight pi-electron system and the cumulative electron-withdrawing effects of the 16 fluorine atoms. An improved method for the synthesis of PCOT and the product resulting from the spontaneous reaction of PCOT with excess alcohol is reported. Crystal structures of the methyl (1) and ethyl (2) derivatives are described.. ...
USA - Moving to USA on L1-B With Pregnant Wife - Hi, My Company is sending me to USA for two years and i have a couple of questions i need help with:
I suppose you think Im going to do something cute like put The End here. You would be wrong to think that, even though I did just put The End. There I did it again. What I intended to show is the pattern on the top of the abdomen. The spider ID books normally make some type of reference to this pattern, so it pays to make note of it. I actually got a lot of shots like this. The spider kept running from me and I had a tough time getting it to stay still long enough to get a full body shot ...
3-thiotriphosphate) The list continues at List of MeSH codes (D20). (Articles with short description, Short description with ... 3' untranslated regions MeSH D13.444.735.790.878.885 - 5' untranslated regions MeSH D13.444.735.828 - rna, viral MeSH D13.570. ... 3' untranslated regions MeSH D13.444.735.544.875.885 - 5' untranslated regions MeSH D13.444.735.615 - rna, neoplasm MeSH ... 3-thiotriphosphate) MeSH D13.695.667.454.504.400 - guanylyl imidodiphosphate MeSH D13.695.667.454.525 - 5'-guanylic acid MeSH ...
The disposition of 3-deazauridine in mice.. R L Cysyk, P E Gormley, M E DAnna and R H Adamson ... The disposition of 3-deazauridine in mice.. R L Cysyk, P E Gormley, M E DAnna and R H Adamson ... The disposition of 3-deazauridine in mice.. R L Cysyk, P E Gormley, M E DAnna and R H Adamson ... The disposition of 3-deazauridine in mice. Message Subject (Your Name) has forwarded a page to you from Drug Metabolism & ...
3. Pai CC, Kearsey SE. A critical balance: dNTPs and the maintenance of genome stability. Genes (Basel) (2017) 8(2):E57. doi: ... Mary M. Hitt2,3 and David H. Evans1,2* *1Faculty of Medicine and Dentistry, Department of Medical Microbiology and Immunology, ... In contrast, the R2 protein is much less stable with a half-life of only ~3 hr. As the demand for dNTPs declines at the end of ... 1-3)]. Although the reported intracellular dNTP concentrations vary greatly depending upon the assay, cell line, and/or tissue ...
3-thiotriphosphate) The list continues at List of MeSH codes (D20). (Articles with short description, Short description with ... 3 untranslated regions MeSH D13.444.735.790.878.885 - 5 untranslated regions MeSH D13.444.735.828 - rna, viral MeSH D13.570. ... 3 untranslated regions MeSH D13.444.735.544.875.885 - 5 untranslated regions MeSH D13.444.735.615 - rna, neoplasm MeSH ... 3-thiotriphosphate) MeSH D13.695.667.454.504.400 - guanylyl imidodiphosphate MeSH D13.695.667.454.525 - 5-guanylic acid MeSH ...
deazauridine. *Uridine_arabinoside. *1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H ...
5(3)-deoxyribonucleotidase, cytosolic type. NT5C. Q8TCD5 details. 5(3)-deoxyribonucleotidase, mitochondrial. NT5M. Q9NPB1 ... 5(3)-deoxyribonucleotidase, cytosolic type. NT5C. Q8TCD5 details. 5(3)-deoxyribonucleotidase, mitochondrial. NT5M. Q9NPB1 ... Thymidine, 3 TMS, GC-MS Spectrum. splash10-0ue9-2910000000-823bcee487948a9c786f. Spectrum. GC-MS. Thymidine, non-derivatized, ... InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1 ...
A 3-fold purification has been reached with a 0.56 % recovery. The purification scheme involved ammonium sulfate precipitation ... A 3-fold purification has been reached with a 0.56 % recovery. The purification scheme involved ammonium sulfate precipitation ... The substrate specificity of the enzyme was investigated using 2-deoxyinosine, allopurinol riboside, 3-deazauridine, and ...
Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2′-deoxycytidine and 3-deazauridine in CANCER CHEMOTHERAPY AND ... Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic ...
These compounds - ribonucleoside analogs 8-azaadenosine, formycin A, 3-deazauridine, 5-fluorocytidine and 2-C-methylcytidine ...
2,3-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by ... 2,3-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by ... Under our experimental conditions, 3-deazauridine and hydroxyurea proved equally as effective as dThd in stimulating ddCyd ... The antiretroviral action of 2,3-dideoxycytidine (ddCyd) depends on its intracellular conversion to the 5-triphosphate ...
We recognized 3-hydroxypyridin-2-thione like a zinc binding group that chelates Zn2+ ion in the active site of HDAC6 and HDAC8 ... Stream Cytometry and Cell Sorting Hearts from 3-week-old to 30-month-old (= 32) C57BL6/J or C57BL/6-Tg (CAG-EGFP) 10sb/J (= 6) ... The entire genome of HEV is 7 approximately.2 kb using a 5 cover and 3 poly(A) [4]. HEV genome encodes three open-reading ... The angiography was performed under circumstances of rigorous sterility, the hearts from the rats had been open and 3 mL ...
McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D. A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. Elife. 2019 09 03; 8 ...
InChI=1S/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-2,6,8-10,12,15-16H,3-4H2/t6-,8-,9-,10-/m1/s1. ...
core: alpha-beta(2)-(alpha-beta)2; 3 layers (a/b/a); mixed beta-sheet of 4 strands, order 2134; strand 1 is antiparallel to the ... Species Mouse (Mus musculus) [TaxId:10090] [186904] (3 PDB entries). *. Domain d1zabd_: 1zab D: [124821]. Other proteins in ... PDB Description: Crystal Structure of Mouse Cytidine Deaminase Complexed with 3-Deazauridine ...
Hemisynthesis of 2,3,4-(13)C3-1,4-Androstadien-3,17-dione: A Key Precursor for the Synthesis of (13)C3-Androstanes and (13)C3- ... Direct C-H Arylation of Indole-3-Acetic Acid Derivatives Enabled by an Autonomous Self-Optimizing Flow Reactor. Vasudevan, N.; ... Direct C sp(2)-H and C sp(3)-H Arylation Enabled by Heterogeneous Palladium Catalysts. Djakovitch, L; Felpin, FX. CHEMCATCHEM, ... Synthesis and Biological Evaluation of 4-C,3-O-Propylene-Linked Bicyclic Nucleosides. Hatton, W; Hunault, J; Egorov, M; Len, ...
3-bis(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-6-(5,6-diamino-2-oxo-2,3,4,5-tetrahydropyrimidin-4-yl)-1,3- ... 3,4-dihydrozebularine 3,5-diamino-2-[(3S,4R,5R,6R)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]-6-(2,3-dichlorophenyl)-1,2lambda5,4- ... 1,3-bis(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-5-amino-5-methyl-6-\{2-oxo-1,3-diazabicyclo[2.2.0]hex-4-en-6-yl ... 4-(5-methyl-3-phenylisoxazol-4-yl)pyrimidin-2-amine 4-(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)butyl dihydrogen ...
Prevention by Testosterone of the Intestinal Toxicity Caused by the Antitumor Agent 3-Deazauridine1 A. Bloch; A. Bloch ... 3-Deazauridine caused a greater increase in the life-span of male than of female DBA/2Ha mice bearing leukemia L1210. The ... Histopathological examination showed the intestinal epithelium to be markedly affected by 3-deazauridine, as evidenced by ... Prevention by Testosterone of the Intestinal Toxicity Caused by the Antitumor Agent 3-Deazauridine1. Cancer Res 1 June 1974; 34 ...
5n-3,create,28-JUN-07,(null),(null) C68367,Fatty_Acid_23_1,create,28-JUN-07,(null),(null) C68368,Gadoleic_Acid,create,28-JUN-07 ... 3_Charge,create,28-JUN-07,(null),(null) C68259,Heme_Iron,create,28-JUN-07,(null),(null) C68260,Heme_Group,create,28-JUN-07,( ... n-3,create,28-JUN-07,(null),(null) C68361,Eicosenoic_Acid,create,28-JUN-07,(null),(null) C68362,Eicosenoic_Acid_n-7,create,28- ... Omega-3_Fatty_Acid,modify,28-JUN-07,(null),(null) C29596,Non-Essential_Amino_Acid,modify,28-JUN-07,(null),(null) C63690,_3_4- ...
3-Deazauridine Preferred Term Term UI T044053. Date01/01/1999. LexicalTag NON. ThesaurusID ... 3-Deazauridine Preferred Concept UI. M0023213. Registry Number. 263CU738ZY. Related Numbers. 23205-42-7. Scope Note. 4-Hydroxy- ... 3-Deazauridine. Tree Number(s). D03.383.742.680.852.250. D13.570.685.852.250. D13.570.800.892.250. Unique ID. D015092. RDF ... Analog of uridine lacking a ring-nitrogen in the 3-position. Functions as an antineoplastic agent.. Entry Term(s). 4-Hydroxy-1 ...
wherein R 1 and R 2 comprise NH or O, and R 3 comprises methyl, ethyl, propyl, CH 2 -O-CH 2 , and (CH 2 -O-CH 2 ) 2 . ... wherein Ri and R 2 comprise NH or O, and R 3 comprises methyl, ethyl, propyl, CH 2 -O-CH 2 , and (CH 2 -O-CH 2 ) 2 . ... The organic layer was extracted twice with 193 mL of 1 M Na 2 CO 3 and then twice with a mixture of 72 mL of 4M HCI and 289 mL ... The organic layer was extracted twice with 150 mL of 1 M Na 2 CO 3 and then twice with a mixture of 53 mL of 4M HCI and 213 mL ...
3-Deazauridine Preferred Term Term UI T044053. Date01/01/1999. LexicalTag NON. ThesaurusID ... 3-Deazauridine Preferred Concept UI. M0023213. Registry Number. 263CU738ZY. Related Numbers. 23205-42-7. Scope Note. 4-Hydroxy- ... 3-Deazauridine. Tree Number(s). D03.383.742.680.852.250. D13.570.685.852.250. D13.570.800.892.250. Unique ID. D015092. RDF ... Analog of uridine lacking a ring-nitrogen in the 3-position. Functions as an antineoplastic agent.. Entry Term(s). 4-Hydroxy-1 ...
Rash3. *Serious cases of tick bite rash may form in people with allergies to the ticks saliva or other emissions, or in those ... Colorado tick fever virus, reovirus 3 KIs-V is a virus isolated in 2011 from four patients with raised serum alanine ... ... Reovirus: Colorado tick fever virus,[22] Reovirus 3[23]. *Atanmamış: Hepatit D ... Arenavirus: Guanarito virus,[2] Junín virus ... Centers for Diseas3. *Formally recognized as a virus in 1946, CTF occurs mostly in people living in or visiting the western ...
3. New Amide Alkaloids from Piper longum. Jiang, Z.Y., W.F. Liu, C.G. Huang, and X.Z. Huang. Fitoterapia, 2012. [Epub ahead of ... Synthesis of C3-arylated-3-deazauridine Derivatives with Potent anti-HSV-1 Activities. Lalut, J., L. Tripoteau, C. Marty, H. ...
Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine. Nucleoside transporters, ... Solute Carrier Family 28 Member 3. DTO Classes. Protein. / Transporter. / Slc Superfamily Of Solute Carriers. / Slc28 And Slc29 ... Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine. Nucleoside transporters, ...
Type 3 D8.811.913.696.620.682.725.400.43 D8.811.913.696.620.682.725.400.179 D12.776.543.750.60.108 D12.776.543.750.60.442 ... G11.561.531.640 Neurotrophin 3 D12.776.467.875.775 D12.644.276.860.775 D23.348.479.875.775 D12.776.467.860.775 D23.348.686.775 ... D23.529.400.235 Endothelin-3 D12.644.276.249.245 D12.644.276.400.245 D12.776.467.400.245 D23.529.400.245 Endothelins D12.644. ... D2.455.426.559.847.885.350 fms-Like Tyrosine Kinase 3 D23.50.301.264.35.284 Focal Dermal Hypoplasia C16.131.260.800.240.350 ...
Many of the categories for particular types of drugs are listed in Category:Drugs by target organ system and Category:Drugs by mechanism of action.
Deazauridine 2 0780.UO.222 Dehydroemetine 2 CLINPHOT INDEX TERMS CAPTIONS APRIL 1982 PAGE CODES FREQUENCY 0780.H0.227 2- ... 3) If a data element specified for a SORT is not contained in a record, then the SORT program sets the value for that missing ... SS (3) PSTG (21) SS 4/C? USER: 3 and female and human PROG: TIME OVFLW: CONT? (Y/N) USER: Y (Searcher may receive more than one ... 3. Find information about the growing number of mothers who want to have their babies at home. SS 2/C? USER: EXP LABOR OR EXP ...
  • Sample search request and analysis of 3:00 - 3:30 the question 7. (nih.gov)
  • Sample search requests and analysis of 8:30 10:00 the questions 10:00 10:30 BREAK 10:30 10:45 3. (nih.gov)