Tetrahydrouridine: An inhibitor of nucleotide metabolism.Rats, Inbred OLETF: An inbred strain of Long-Evans rats that develops hyperglycemia, hyperinsulinemia, and mild obesity, mostly in males, that resembles non-insulin-dependent diabetes mellitus in humans. It was developed from outbred Long-Evans stock in 1983.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.DCMP Deaminase: An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12.UridineCytidine Deaminase: An enzyme that catalyzes the deamination of cytidine, forming uridine. EC 3.5.4.5.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Apicomplexa: A phylum of unicellular parasitic EUKARYOTES characterized by the presence of complex apical organelles generally consisting of a conoid that aids in penetrating host cells, rhoptries that possibly secrete a proteolytic enzyme, and subpellicular microtubules that may be related to motility.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Purine-Pyrimidine Metabolism, Inborn ErrorsIsosorbide: 1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma.Coated Materials, Biocompatible: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.Illusions: The misinterpretation of a real external, sensory experience.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Friction: Surface resistance to the relative motion of one body against the rubbing, sliding, rolling, or flowing of another with which it is in contact.Neural Networks (Computer): A computer architecture, implementable in either hardware or software, modeled after biological neural networks. Like the biological system in which the processing capability is a result of the interconnection strengths between arrays of nonlinear processing nodes, computerized neural networks, often called perceptrons or multilayer connectionist models, consist of neuron-like units. A homogeneous group of units makes up a layer. These networks are good at pattern recognition. They are adaptive, performing tasks by example, and thus are better for decision-making than are linear learning machines or cluster analysis. They do not require explicit programming.AlaskaSeeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Chromatography, Ion Exchange: Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.N-Glycosyl Hydrolases: A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Molecular Weight: The sum of the weight of all the atoms in a molecule.Peas: A variable annual leguminous vine (Pisum sativum) that is cultivated for its rounded smooth or wrinkled edible protein-rich seeds, the seed of the pea, and the immature pods with their included seeds. (From Webster's New Collegiate Dictionary, 1973)Prokaryotic Cells: Cells lacking a nuclear membrane so that the nuclear material is either scattered in the cytoplasm or collected in a nucleoid region.Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Luminescence: Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Eukaryotic Cells: Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane.Pyrimidine Nucleosides: Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Heterocyclic Compounds, 2-Ring: A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.Uridine Phosphorylase: An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Azacitidine: A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.Thymidine Kinase: An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.Organophosphonates: Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)United States National Aeronautics and Space Administration: An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.Surgical Mesh: Any woven or knit material of open texture used in surgery for the repair, reconstruction, or substitution of tissue. The mesh is usually a synthetic fabric made of various polymers. It is occasionally made of metal.United StatesNational Health Insurance, United StatesPolypropylenes: Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.MEDLARS: A computerized biomedical bibliographic storage and retrieval system operated by the NATIONAL LIBRARY OF MEDICINE. MEDLARS stands for Medical Literature Analysis and Retrieval System, which was first introduced in 1964 and evolved into an online system in 1971 called MEDLINE (MEDLARS Online). As other online databases were developed, MEDLARS became the name of the entire NLM information system while MEDLINE became the name of the premier database. MEDLARS was used to produce the former printed Cumulated Index Medicus, and the printed monthly Index Medicus, until that publication ceased in December 2004.

Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. (1/16)

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Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia. (2/16)

Pyrazofurin (NSC 143095) as the monophosphate derivative is a potent inhibitor of orotidine 5'-monophosphate (OMP) decarboxylase of the pyrimidine pathway and has been proposed to inhibit 5-aminoimidazole-4-carboxamide ribotide (AICAR) transformylase (EC 2.1.2.3) of the purine pathway (J. F. Worzalla, and M. J. Sweeney, Pyrazofurin inhibition of purine biosynthesis via 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate formyltransferase. Cancer Res., 40: 1482-1485, 1980). Measurement of levels of pyrimidine and purine intermediates in cultured mouse L1210 leukemia cells has shown that 25 microM pyrazofurin induces an 8-fold accumulation of OMP and large accumulations of intermediates proximal to the blockade with abrupt decreases in uridine and cytidine nucleotides. Considerable increases in the cellular concentrations of N-succino-AICAR (SAICAR), AICAR, 5-formamidoimidazole-4-carboxamide ribotide (FAICAR), IMP, XMP, and GMP at later times indicate that AICAR transformylase is not significantly inhibited in cultured cells; rather the purine pathway and the GMP branch are stimulated. However, addition of 25 microM 3-deazauridine (NSC 126849) to leukemia cells did result in inhibition of AICAR transformylase: AICAR and SAICAR accumulated, IMP disappeared and there was a large accumulation of guanosine nucleotides. Blockade of pyrimidine biosynthesis by derivatives of pyrazofurin or 3-deazauridine spares 5-phosphoribosyl-1-pyrophosphate and L-glutamine, elevated concentrations of which may stimulate initial reactions of purine biosynthesis and the reaction XMP----GMP.  (+info)

Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in cultured human leukemic RPMI 6410 cells. (3/16)

When incubated with 1-beta-D-arabinofuranosylcytosine (ara-C), RPMI 6410 cells formed a hitherto unrecognized ara-C metabolite, 1-beta-D-arabinofuranosylcytosine diphosphate choline. This compound was characterized by (a) chromatographic behavior, (b) chemical and enzymatic hydrolysis, (c) phosphorus content, and (d) incorporation of [5-3H]ara-C and [methyl-14C]choline. Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline by RPMI 6410 cells was enhanced in the presence of 3-deazauridine (DU) and was preceded by that of 1-beta-D-arabinofuranosylcytosine triphosphate. The antiproliferative effects of ara-C and DU toward RPMI 6410 cells were potentiated when the agents were present together. The anabolism of ara-C during a 24-hr interval of culture was markedly enhanced by the presence of DU; cellular concentrations of 1-beta-D-arabinofuranosylcytosine triphosphate and 1-beta-D-arabinofuranosylcytosine diphosphate choline were 5- and 15-fold higher than those in the absence of DU. This enhancement appears to be the basis of the potentiation of cytotoxicity resulting from combination of the agents. Pretreatment of RPMI 6410 cells with DU resulted in enhanced rates of cellular uptake of ara-C. ara-C uptake under these circumstances was blocked by the inhibitor of nucleoside transport, nitrobenzylthioinosine.  (+info)

Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in neoplastic and normal cells. (4/16)

1-beta-D-Arabinofuranosylcytosine diphosphate choline was formed from 1-beta-D-arabinofuranosylcytosine (ara-C) during incubation in vitro of peripheral myeloblasts from patients with acute myelogenous leukemia and cultured cells (nonleukemic human lymphocytes, mouse lymphoma L5178Y, and HeLa); as well, 1-beta-D-arabinofuranosylcytosine diphosphate choline was formed in vivo in mouse leukemia L1210 cells and mouse liver. 3-Deazauridine enhanced the anabolism of ara-C in nonleukemic lymphocytes in vitro and leukemia L1210 cells in vivo but did not influence ara-C anabolism in the other cell types. In acute myelogenous leukemia myeloblasts incubated in vitro with ara-C, concentrations of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate were maximal after 8 hr of incubation and formation of the latter preceded that of 1-beta-D-arabinofuranosylcytosine diphosphate choline.  (+info)

Effects of pyrimidine antagonists on sialic acid regeneration in HL-60 cells. (5/16)

Because alterations in cell membrane sialoglycoconjugates can affect the behavior of neoplastic cells, we investigated the effects of in vitro treatment with antimetabolites used in cancer therapy on the expression of membrane sialic acid in cultured HL-60 leukemic cells. In these studies, cells were incubated with Vibrio cholerae neuraminidase to remove surface sialic acid. Reappearance of membrane sialic acid during drug treatment was followed (a) by measuring changes in radioactive surface labeling of viable cells with sodium metaperiodate-sodium[3H]-borohydride, (b) by measuring the decline in accessible surface galactosyl receptor sites which occurred coincident with membrane sialic acid replacement, and (c) by measuring the incorporation of [3H]glucosamine into membrane-associated neuraminidase-labile sialic acid. We were especially interested in learning whether drugs that affect intracellular pools of cytidine triphosphate (CTP), an important nucleotide intermediate in sialylation reactions, could inhibit regeneration of membrane sialic acid. 3-Deazauridine, a competitive inhibitor of CTP synthetase, depleted CTP pools and curtailed surface membrane resialylation with little or no effect on synthesis of de novo sialic acid from precursor sugars. The addition of cytidine restored CTP pools and sialic acid regeneration. Acivicin, a glutamine antagonist, also depleted CTP pools and curtailed surface membrane resialylation. In addition, it retarded de novo synthesis of sialic acid. The addition of cytidine restored intracellular CTP pools and sialic acid regeneration. However, both cytidine and guanosine were required to restore sialic acid synthesis from precursor sugars. 1-beta-D-Arabinofuranosylcytosine, a competitive inhibitor of sialic acid synthetase and of sialyltransferase, inhibited both de novo sialic acid synthesis and membrane resialylation. Only the latter effect was reversed by the addition of exogenous cytidine. Hydroxyurea, an agent shown previously to inhibit glycoconjugate production in hamster fibroblasts, curtailed membrane resialylation and de novo synthesis of sialic acid without depleting CTP pools. Doxorubicin, at levels that caused marked arrest of cell proliferation, had no effect on sialic acid synthesis or expression on the membrane surface. These data suggest that antimetabolites, apart from their cytotoxic effects or effects on cellular growth, may directly inhibit the expression of membrane sialic acid.(ABSTRACT TRUNCATED AT 400 WORDS)  (+info)

Drug sequence-dependent toxicity and small bowel mucosal injury in mice treated with low doses of 3-deazauridine and 1-beta-D-arabinofuranosylcytosine. (6/16)

The toxicity to mice of combinations of 1-beta-D-arabinofuranosylcytosine and 3-deazauridine was investigated. The drugs were administered daily i.p. on Days 1 to 5, each drug at 10 mg/kg body weight; these dosages are small fractions of the dosages at which 10% of the treated animals died when either drug was administered alone on the foregoing schedule. This drug combination was severely toxic when 3-deazauridine was administered 2 to 8 hr prior to 1-beta-D-arabinofuranosylcytosine; most mice treated in this way died within 3 days of the last treatment. Histological examination showed that severe damage to the small bowel mucosa resulted from treatment with the drugs in the above, lethal sequence. In contrast, treatments with this drug combination at the same dosages were tolerated when the two agents were administered simultaneously or when 1-beta-D-arabinofuranosylcytosine preceded 3-deazauridine. Under the latter conditions, small bowel mucosal injury was much less severe. Female mice were more sensitive to the toxic treatment regimen than were male mice and were protected against the latter when either the 3-deazauridine or the 1-beta-D-arabinofuranosylcytosine component was preceded by treatment with nitrobenzylthioinosine (100 mg/kg), a potent inhibitor of nucleoside transport.  (+info)

Synergistic action of 5-aza-2'-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells. (7/16)

The biochemical and biological effects of the combination of 5-aza-2'-deoxycytidine (5-aza-dCyd) and 3-deazauridine (3-DU) on L1210 leukemic cells and EMT6 tumor cells were investigated. The cytotoxic action of 5-aza-dCyd and 3-DU on both L1210 and EMT6 cells in vitro was synergistic when these agents were used in combination. The combination of 5-aza-dCyd and 3-DU produced a greater inhibition of in vitro growth of L1210 and EMT6 cells than did either agent alone. The in vivo antineoplastic activity of this combination was synergistic with respect to the increased survival time of BALB/c x DBA/2 F1 mice with L1210 leukemia. 3-DU, an agent that reduces the intracellular pool size of cytosine nucleotides, stimulated the incorporation of [3H]-5-aza-dCyd into DNA of both L1210 and EMT6 cells, suggesting that the synergistic action of this combination is related to the increased incorporation of 5-aza-dCyd in the presence of 3-DU.  (+info)

Penetration of 3-deazauridine into human brain, intracerebral tumor, and cerebrospinal fluid. (8/16)

The antitumor agent 3-deazauridine (DAU) was administered rapidly to four patients before surgical removal of intracerebral tumor. Tumor, adjacent brain tissue, and temporalis muscle were assayed for DAU by high-pressure liquid chromatography. DAU penetrated comparably into tumor, brain, and muscle; in one patient, tissue concentrations were higher than concurrent plasma concentrations. The active metabolite 3-deazauridine 5'-triphosphate was quantitated in one tumor sample and greatly exceeded its Ki for cytidine 5'-triphosphate synthetase. DAU was also present in autopsy brain specimens from two patients treated shortly antemortem. Cerebrospinal fluid concentrations were 22.1 and 59.0%, respectively, of concurrent plasma concentrations during continuous infusion of DAU in two patients. Cerebrospinal fluid concentration was 3.1 microgram/ml 2 hr after a 30-min infusion of 1.5 g of drug per sq m and fell to 1.9 microgram/ml at 16 hr. Thus, DAU is capable of penetrating into intracerebral tumor, brain, and cerebrospinal fluid and is worthy of investigation in the treatment of intracerebral and meningeal neoplasms.  (+info)

Define Antimetabolic agent. Antimetabolic agent synonyms, Antimetabolic agent pronunciation, Antimetabolic agent translation, English dictionary definition of Antimetabolic agent. n. A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite. an′ti·met′a·bol′ic...
Synonyms for Antimetabolic agent in Free Thesaurus. Antonyms for Antimetabolic agent. 9 words related to antimetabolite: antineoplastic, antineoplastic drug, cancer drug, fluorouracil, mercaptopurine, Purinethol, amethopterin, methotrexate.... What are synonyms for Antimetabolic agent?
Mouse monoclonal antibody raised against native NCAM1. Native purified NCAM1 from KG-1 human acute myelogenous leukemia cell line. (MAB5003) - Products - Abnova
Nutrient limitation occurs during physiological tissue growth or as a consequence of various pathological events, such as wounds or vascular occlusions that lead to transient ischemia. To recover, ischemic tissues employ mechanisms that promote wound healing and the restoration of the nutrient flux. These mechanisms include angiogenesis and inflammation, which have been classically attributed to hypoxia or to necrotic inflammatory signals, respectively. We show here that nutrient deprivation could be, by itself, a powerful signal to induce inflammation as part of a normal wound-healing response as pathogens and sterile injuries trigger similar events which include the recruitment of the innate immune system. It is possible that nutrient deprivation followed by the ISR is one of the many signals that the body uses to detect infections as pathogens also deprive nutrients from the site of infection. In fact, the kinase PKR, that detects viral dsRNA, is one of the kinases that activate the ISR ...
This youth enhancing Vita-Peptide Eye Gel contains essential vitamins & antioxidants as well as specially selected peptides plus hyaluronic acid regeneration technology. It assists in reducing the visible signs of ageing, promoting a youthful luminous, smooth and plumped appearance. BENEFITS FOR YOUR SKIN Contains
Youth EssentiA Vita-Peptide Eye Gel is a new scientifically advanced formulation which intelligently combines a highly specialized system of essential vitamins (A,C & E), antioxidants, peptides, and a new hyaluronic acid regeneration technology, Optim-Hyal™. This light weight eye gel assists in restoring the benefi
This is a third-party research done by a grant from YuFoundation for Tom Seyfried to research Dr. Young Kos 3 Bromopyruvate antimetabolic drug used in cancers. The important outcome is when 3 BP was injected into the primary cancer site, the metastatic rate was impressively low. Therefore, spread of the cancers may be hindered with this molecule. Please read more in section under grants and scientific information.. ...
CDP-choline stands for cytidine-5Í-diphosphate choline. This unique form of choline readily passes through the blood-brain barrier (BBB) directly into the brain tissue. Once past the blood-brain barrier, CDP-choline activates the synthesis of critical components in cell membranes, enhances cerebral energy metabolism and increases levels of various neurotransmitters.. Supplement ...
Definition of cytidine diphosphate choline. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. Positive clinical results were suggested to result from rapid and effective DNA-crosslinking following uptake in neoplastic cells, but also from antimetabolic properties of the drug. Although m-L-sarcolysin never reached widespread clinical use, the well established para-isomer melphalan still, after nearly fifty years, has a place in cancer chemotherapy.. The present study was undertaken to synthesise the melphalan containing analogue of the tripeptide P2 (L-prolyl-m-L-sarcolysyl-p-L-fluorophenylalanine ethyl ester, the main contributor to Peptichemios activity) and similar compounds, preferably dipeptides. The new compounds compared favourably with melphalan, m-L-sarcolysin ...
In the compound sodium flouride, NaF, the sodium atom loses one electron and the fluorine atom gains one electron to form ions that have electron configurations similar to _____. ...
Senescence Effects of Angelica sinensis Polysaccharides on Human Acute Myelogenous Leukemia Stem and Progenitor Cells Angelica sinensis polysaccharide;leukemia stem/progenitor cells;senescence;telomerase;telomere; Leukemia stem cells (LSCs) play important roles in leukemia initiation, progression and relapse, and thus represent a critical target for therapeutic intervention. Hence, it is extremely urgent to explore new therapeutic strategies directly targeting LSCs for acute myelogenous leukemia (AML) therapy. We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML $CD34^+CD38^-$ cell proliferation in vitro culture in a dose-dependent manner while sparing normal hematopoietic stem and progenitor cells at physiologically achievable concentrations. Furthermore, ASP exerted cytotoxic effects on AML K562 cells, especially LSC-enriched $CD34^+CD38^-$ cells. Colony formation assays further showed that ASP
NioCorp $NB $NIOBF $BR3 #Niobium #Scandium #ElkCreek. About NioCorp. NioCorp is developing a superalloy materials project in Southeast Nebraska that will produce Niobium, Scandium, and Titanium. Niobium is used to produce superalloys as well as High Strength, Low Alloy ("HSLA") steel, which is a lighter, stronger steel used in automotive, structural, and pipeline applications. Scandium is a superalloy material that can be combined with Aluminum to make alloys with increased strength and improved corrosion resistance. Scandium also is a critical component of advanced solid oxide fuel cells. Titanium is used in various superalloys and is a key component of pigments used in paper, paint and plastics and is also used for aerospace applications, armor and medical implants.. Cautionary Note Regarding Forward-Looking Statements Neither TSX nor its Regulation Services Provider (as that term is defined in the policies of the TSX) accepts responsibility for the adequacy or accuracy of this document. ...
0123] On the other hand, a monomer having fluorine at its ester moiety is an acrylic acid ester or methacrylic acid ester having a unit where the ester moiety is a perfluoroalkyl group or a fluoroalkyl group serving as a flurine-containing group or a unit having both a cyclic structure and a fluorine atom at a-position, the cyclic structure being a fluorine-containing benzene ring, fluorine-containing cyclopentane ring, fluorine-containing cyclohexane ring or fluorine-containing cycloheptane ring or the like in which substitution with a fluorine atom, trifluoromethyl group, hexafluoroisopropyl hydroxyl group or the like has been made. It is also possible to use an acrylic acid or methacrylic acid ester having a fluorine-containing t-butyl ester group at ester moiety. It is also possible to use monomers in which these fluorine-containing functional groups are used in combination with a fluorine-containing alkyl group of a-position. Of such units, as particularly typical ones are exemplarily ...
For regeneration of pickling acids in your steel mill, the PYROMARS (mixed acid regeneration) plant from ANDRITZ METALS is an efficient and effective solution. The high recovery rates of 99% hydrofluoric acid, 80% nitric acid, and 99% metals need no further comment.
Norm Lieberman has been a process engineer for 50 years. His first employment was with AMOCO Oil as a process design engineer. He worked at Texas City as an operating superintendent of alkylation, sulfuric acid regeneration, and mercaptan extraction. Norm has designed: • Sulfur Plants • Amine Regenerators • Delayed Cokers • Crude Units • Vacuum Towers Hes the author of several well known troubleshooting books: • A Working Guide to Process Equipment • Process Design for Reliable Operations • Troubleshooting Natural Gas Processing • Troubleshooting Process Operations • Troubleshooting Process Plant Control • Process Engineering for a Small Planet • Process Equipment Malfunctions • Troubleshooting Vacuum Systems • My Race Against Death He has instructed 820 process troubleshooting seminars, attended by over 19,000 engineers and experienced operators since 1983. Mr. Lieberman is still actively involved in field troubleshooting and instructing process seminars. In 2015, ...
60 Vegetarian capsules Optimize Your Brain Function * Enhances memory in the elderly * Supports balanced mood and cognitive function * Promotes phospholipid balance in the brain and enhances neurotransmitter production * Clinically shown to aid in recovery from traumatic brain injury Citicoline is cytidine diphosphate choline, or CDP-choline, a nutrient that has been shown to support memory in patients with age-associated memory impairment, and brain cell recovery from injuries such as stroke or concussion. Citicoline also increases the production of key neurotransmitters, including acetylcholine, norepinephrine, dopamine, and serotonin, all of which are essential for mood balance and memory. Additionally, it supports nerves in the eye, and studies administering Citicoline to patients with lazy-eye and other vision disorders have noted beneficial results. The main component of Citicoline is its cytidine group, which is what Citicoline delivers to
Okabayashi, T; Mihara, S; Repke, D B.; and Moffatt, J G., "A radioimmunoassay for 1-beta-d-arabinofuranosylcytosine." (1977). Subject Strain Bibliography 1977. 1646 ...
Bună sara! Ne-am mutat la casâ nouâ șî am zâs câ ar fi ghini sâ vă cinstesc oleacă! Am pentru voi o sacoșâ cu dulșiuri șî niști bieri. Aș fi vrut sâ vă dau o tavâ cu poale-n brâu șî Continue reading Bre, dam premii pi digeaba!→. ...
Bună sara! Ne-am mutat la casâ nouâ șî am zâs câ ar fi ghini sâ vă cinstesc oleacă! Am pentru voi o sacoșâ cu dulșiuri șî niști bieri. Aș fi vrut sâ vă dau o tavâ cu poale-n brâu șî Continue reading Bre, dam premii pi digeaba!→. ...
Colorado Tick Fever. In: Hay, Jr WW, Levin MJ, Deterding RR, Abzug MJ. Hay, Jr W.W., Levin M.J., Deterding R.R., Abzug M.J. Eds. William W. Hay, Jr, et al.eds. Quick Medical Diagnosis & Treatment Pediatrics New York, NY: McGraw-Hill; . http://accesspediatrics.mhmedical.com/content.aspx?bookid=2196§ionid=166956538. Accessed January 20, 2018 ...
TY - CHAP. T1 - Tissue distribution and intracerebral tumor penetration of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZO, NSC 182986) in man. AU - Savaraj, Niramol. AU - Lu, K.. AU - Stewart, D.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=17544399898&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=17544399898&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:17544399898. VL - Vol. 22. BT - Proceedings of the American Association for Cancer Research. ER - ...
This chapter discusses the de novo pathway of pyrimidine nucleotide biosynthesis. Animals do not have a dietary requirement for pyrimidines, and many microorgan
A team of MIT chemists has devised a new way to add fluorine to a variety of compounds used in many drugs and agricultural chemicals, an advance that could offer more flexibility and potential cost-savings in designing new drugs.. Drug developers commonly add fluorine atoms to drugs, such as the cholesterol-lowering rosuvastatin, to keep the body from breaking them down too quickly. Many of these drugs contain aromatic rings - a type of six-carbon ring - and attaching a fluorine atom to the rings can be a difficult, expensive process.. "Its hard to add fluorine at a late stage, once you have a complete molecule already put together, because traditional methods can be quite harsh with respect to temperature or other factors," says Stephen L. Buchwald, the Camille Dreyfus Professor of Chemistry at MIT.. In their new technique, Buchwald and his colleagues used a palladium catalyst to attach a fluorine atom to aromatic compounds. The technique could be used in the design and testing of new drugs, ...
Recently much attention has been devoted to crystals containing organic ions and inorganic ions due to the possibility of tuning their special structural features and their potential ferroelectrics properties (Fu et al., 2011; Zhang et al., 2010.).. The compound (C4H12O3N)+(C2F3O2)- has an asymmetric unit that consists of one tris(hydroxymethyl)methanaminium cation and one trifluoroacetate anion (Fig 1). N-H···O and O-H···O hydrogen bonds form a complex three-dimensional network, (Fig 2). The trifluoromethyl group is quite mobile, but examination of a difference map in the plane of the fluorine atoms does show that the fluorine atoms exist as three distinct atoms.. For structure of the related tris(hydroxymethyl)methanaminium hydrogenhalides seen (Rudman et al., 1983).. ...
2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug.[1] 2-Fluoroamphetamine differs from 3- and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood-brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by the substitute.[2][3] ...
The bonding within dioxygen difluoride has been the subject of considerable speculation over the years, particularly because of the very short O-O distance and the long O-F distances. Bridgeman has proposed a scheme which essentially has an O-O triple bond and an O-F single bond that is destabilised and lengthened by repulsion between the lone pairs on the fluorine atoms and the π-orbitals of the O-O bond.[3] Repulsion involving the fluorine lone pairs is also responsible for the long and weak covalent bonding in the fluorine molecule.. ...
Colorado tick fever virus ATCC ® VR-1233CAF™ Designation: Colorado tick fever control ascitic fluid [V-506-401-562] Application:
Results of the present study show for the first time that Chk1 undergoes activating phosphorylation in marrow blasts in vivo during cytarabine-containing induction therapy. Building on this result, we also show in human AML cell lines that the selective Chk1 inhibitor SCH 900776 abrogates cytarabine-induced S-phase arrest, increases cytarabine-induced apoptosis, and enhances the effects of cytarabine on colony formation. Likewise, SCH 900776 increases the effects of cytarabine in a majority of primary AML isolates but not normal myeloid progenitors in vitro. This sensitization was observed at SCH 900776 concentrations far below the approximate 5 μmol/L SCH 900776 peak levels observed at the maximum tolerated dose in solid tumor patients. These observations have potentially important implications for current efforts to enhance the efficacy of cytarabine-containing AML regimens.. Previous results have shown that cytarabine activates the ATR/Chk1 checkpoint in tissue culture cell lines in vitro ...
http://www.wisegeek.com/what-is-nucleotide-biosynthesis.htm Nucleotide biosynthesis is the process whereby nucleotides are created or synthesized. This process
The idea of ​​anabolism refers to a series of metabolism processes that involve the synthesis of different complex molecules through other molecules of greater simplicity. Anabolism, in this way, consists in the synthesis of certain biomolecules from molecules that, in comparison, are simpler.
Uongozi wa Manchester United umeamua kufanya kweli baada ya kutangaza kumuongezea mkataba wa miaka mitano kocha wake, Jose Mourinho kwa dau la Paui 65
Colorado tick fever (CTF) is a disease caused by an RNA virus, Colorado tick fever virus (CTFV). Symptoms, which are often non-specific, begin 3 to 5 days after the bite with an abrupt onset of fever and any of these: headaches, chills, malaise, photophobia, myalgias, nausea, vomiting, diarrhea and abdominal pain. In 5 to 15% of cases a rash occurs. Neurologic complications may also occur. 50% of patients have single recurrence of fever ("saddleback" fever).. IFA titers for diagnosis. PCR (Polymerase Chain Reaction) is the test most often used to diagnose the disease. CTF is transmitted by Dermacentor andersoni (Rocky Mt. wood tick) which causes illness from the Western Black Hills to the West Coast in the USA. Some cases of transmission through blood transfusion have been reported. Treatment consists of supportive care.. ©LDA. 2014. 2015. This web site provides practical and useful information on the subject matters covered. It is distributed with the understanding that LDA is not engaged in ...
Abstract Isolation of the virus, the most reliable means of diagnosing Colorado tick fever, is not always practicable. The standard complement-fixation test, using a mouse-brain-derived antigen, may not detect significant rises in antibody titer during the usual 2- or 3-week observation period. Complement-fixation (CF) tests, with antigens derived from infected mouse brains and from an established line of hamster-kidney cells, were compared with a neutralization (plaque-reduction) test and an indirect fluorescent-antibody (IFA) staining test for usefulness in the serologic diagnosis of 34 cases of Colorado tick fever. The cell-culture antigen was as reliable as the mouse-brain antigen, and its preparation was simpler. The CF-antibody titers and the neutralizing-antibody titers tended to be lower and slower to appear than the IFA titers. The IFA method was simple, rapid, and accurate. The IFA titers frequently appeared earlier after onset of illness and reached higher levels than did the CF titers.
Learn more about Colorado Tick Fever at Atlanta Outpatient Surgery Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
The Japanese B Encephalitis Vaccination is available at our clinic to protect you on your travels. Call us on 01256 354981 to make an appointment.
In a new paper, Partha Bera and colleagues at NASAs Ames Research Center and Purdue University put these gases under the microscope to find out exactly why they are such powerful heat trappers. They focus on CFCs, HFCs and PFCs - all chemicals containing fluorine or chlorine - that are used in medicine, fridges, and as solvents, among other things. By probing the molecular structure of these compounds, they have found that molecules containing several fluorine atoms are especially strong greenhouse gases, for two reasons. First, unlike many other atmospheric molecules, they can absorb radiation that makes it through our atmosphere from space. Second, they absorb the radiation (and trap the heat) very efficiently, because of the nature of the fluorine bonds inside them. (In technical terms, fluorine atoms create a larger separation of electric charge within the molecule, and this helps the molecular bonds absorb electromagnetic radiation more effectively.) HFCs and other fluorine-based gases ...
Another name for Mediterranean Tick Fever is Boutonneuse Fever. Physicians from the following specialties evaluate and treat boutonneuse fever: * Infectious ...
When Fausto was found, he was running desoriented in the middle of the road among the cars, very thin and covered with wounds that did not seem to be healing. We took him to the vet who did the snap blood tests and it resulted that he had a tick fever and a suspicion of leshmaniasis. When a dog has a tick fever, the leshmaniasis test is very often inconclusive - neither positive nor negative but suspected. The tick fever influences the results so it is advisable to cure the tick fever first and then repeat the leshmaniasis test. So we did ...
Fluorocarbon polymer, any of a number of organic polymers whose large, multiple-unit molecules consist of a chain of carbon atoms to which fluorine atoms are appended. Owing to the presence of the highly polar fluorine atoms, which form extremely strong bonds with the carbon chain and resist
I am not sure whether (1) the dopant fluorine atoms group pairwise at iron atoms and (2) if the decorated iron atoms indeed form a superlattice. However, this may be checked experimentally. But then, (3), if there is a superlattice, it is not clear to me why it should be ordered in the way claimed in the paper, with a pattern stacking five unit cells on top of each other for "COFFA", for example. There can be many ways to arrange unit cells to form a superlattice with the right supercell volume. This is more obvious in the case of "LOFFA", where the supercell comprises 18 unit cells, and there seems to be no a priori reason to select a superstructure which has 6 unit cells stacked on top of each other ...
I suppose you think Im going to do something cute like put "The End" here. You would be wrong to think that, even though I did just put "The End". There I did it again. What I intended to show is the pattern on the top of the abdomen. The spider ID books normally make some type of reference to this pattern, so it pays to make note of it. I actually got a lot of shots like this. The spider kept running from me and I had a tough time getting it to stay still long enough to get a full body shot ...
Colorado tick fever is a condition acquired from a bite of the Dermacentor andersoni wood tick. Learn to recognize the indications by reading here.
All the Dogs owners asked this common question as to how can we identify the Dog Tick Fever? No worries, we will help you. If a dog has tick fever which appears in acute, sub-clinical and chronic stages. Acute will experience symptoms such as respiratory troubles, swollen lymph nodes, loss of weight, fever, bleeding problems, and neurological issues. It appears in the beginning stages of tick fever. In fact, sub-clinical stage of Dog Tick Fever, display zero indication of the disease. So that dont exhibit symptoms and the dog possesses a good immune system, they could potentially fight off tick fever during the sub-clinical period. In the chronic stages, they might display severe symptoms such as anemia, vision difficulties, eye hemorrhaging is one example and lameness, uncontrollable bleeding, limb swelling, and failure of the bone marrow. Then their health condition characterized by low blood-platelet counts. So that chronic ehrlichiosis sometimes succumbs to the ailment.. Beyond that, After ...
level. The fluorine atoms are detected by one of two methods: observing the fluorescencedecay to the 2PJ level or observing F+ production through the absorption of an additional photon by the excitedatoms. We have measured relative two-photon absorption cross sections to and the radiative lifetimes of the ...
The research presented in this thesis concerns the synthesis of oligodeoxynucleotide (ODN) conjugates and their use in the photochemical induction of oxidative damage to specific nucleic acid bases in a complementary ODN target strand as shown below: 5`T G A C C A T C A A T A A G G A A G A A G C C C T T C A G C G G C C3`, 3`G G T A G T T A T T C C T T C T T -sensitiser. The target strand used is an ODN model of the bcr/abl oncogenic mRNA present in chronic myeloid leukaemia (CML). As such, the aim of this research is the development of potential photoactive antisense agents, which could be used in future experiments to hinder expression of the oncogenic mRNA and be used in the development of therapeutic agents to treat CML. ODN conjugates were synthesised with photosensitising molecules, which were derivatives of a ruthenium polypyridyl complex and pteridinone derivatives. Thus, molecules were synthesised with functional groups that could be activated towards couplin... ...
anabolism. Anabolism | Article about anabolism by The Free Dictionary. Revitol Complete is a cutting edge anti wrinkle solution which can help you look younger and more beautiful by reducing the appearance of wrinkles, fine lines and other effects of aging.
Colorado tick fever (CTF) (also called mountain tick fever, American tick fever, and American mountain tick fever) is a viral infection (Coltivirus) transmitted from the bite of an infected Rocky Mountain wood tick (Dermacentor andersoni). It should not be confused with the bacterial tick-borne infection, Rocky Mountain spotted fever. The type species of the genus Coltivirus, Colorado tick fever virus (CTFV) infects haemopoietic cells, particularly erythrocytes, which explains how the virus is transmitted by ticks and also accounts for the incidence of transmission by blood transfusion. The disease develops from March to September, with the highest infections occurring in June. The disease is found almost exclusively in the western United States and Canada, mostly in high mountain areas such as Colorado and Idaho. The CTFV was first isolated from human blood in 1944. The virus particle, like other coltiviruses, is about 80 nm in diameter and is generally not enveloped. The double-stranded RNA ...
Hexafluoropropylene oxide (HFPO) compounds, including polymers, expressed by the general chemical formula (1) below: ##STR1## wherein R1 is a single bond, an alkylene group of 1 to 10 carbon atoms, or said alkylene group in which a part of, or all of, the hydrogen atoms are substituted by fluorine atoms, Rf is a fluorine atom, a perfluoroalkyl group of 1 to 10 carbon atoms, or a perfluoroalkyl ether group, and n is 0 or an integer of at least 1. A manufacturing method for the HFPO compounds which is characterized by the reaction between hexafluoropropylene oxide and a vinyl group containing compound, expressed by the general chemical formula (2) below: ##STR2## wherein R1 and Rf are same as above. The compounds have utility as important intermediate raw materials for the production of novel functional silicone compounds having HFPO polymer units.
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3' untranslated regions MeSH D13.444.735.544.875.885 --- 5' untranslated regions MeSH D13.444.735.615 --- rna, neoplasm MeSH ... 3' untranslated regions MeSH D13.444.735.790.878.885 --- 5' untranslated regions MeSH D13.444.735.828 --- rna, viral MeSH ... 3-deazauridine MeSH D13.570.800.892.628 --- pseudouridine MeSH D13.570.800.892.800 --- tetrahydrouridine MeSH D13.570.800.892. ... 3-thiotriphosphate) MeSH D13.695.667.454.504.400 --- guanylyl imidodiphosphate MeSH D13.695.667.454.525 --- 5'-guanylic acid ...
Hemisynthesis of 2,3,4-(13)C3-1,4-Androstadien-3,17-dione: A Key Precursor for the Synthesis of (13)C3-Androstanes and (13)C3- ... Practical Pd/C-Catalysed Suzuki-Miyaura Reactions for the Preparation of 3-Aryl-4-oxypyridin-2(1H)-ones, 3-Aryl-2,4- ... ACS OMEGA, 3 (8), 9155-9159, doi, ImpFact5: not available. An Autonomous Self-Optimizing Flow Reactor for the Synthesis of ... ORGANIC LETTERS, 20 (3), 792-795, doi, ImpFact5: 6.492. One-Pot Synthesis of Functionalized Fused Furans via a BODIPY-Catalyzed ...
Effects of 2-deoxy-D-glucose and 3 deazauridine individually and in combination on the replication of Japanese B encephalitis ...
V=1698.02(7)Å3 For Z=6 and F.W.=268.22, the calculated density is 1.574 g/cm3. Based on the systematic absences of: 0001:1±3n ... P3121(#152). The data is collected at a temperature of −123±1° C. to a maximum 2θ value of 136.4°. A total of 111 oscillation ... Table 3 lists the weights of the livers and spleens of mice on autopsy. All mice except for the one 0.1 mg/kg decitabine i.p. ... Example 3. 2′(S)-fluoro-2′ deoxy-dihydrouridine [(S)-FDHU, 31]. Compound 30 (1.2 g, 4.0 mmol) is dissolved in H2O (40 mL). ...
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to ... Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to ... Title: Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP ...
3 untranslated regions MeSH D13.444.735.544.875.885 --- 5 untranslated regions MeSH D13.444.735.615 --- rna, neoplasm MeSH ... 3 untranslated regions MeSH D13.444.735.790.878.885 --- 5 untranslated regions MeSH D13.444.735.828 --- rna, viral MeSH ... 3-deazauridine MeSH D13.570.800.892.628 --- pseudouridine MeSH D13.570.800.892.800 --- tetrahydrouridine MeSH D13.570.800.892. ... 3-thiotriphosphate) MeSH D13.695.667.454.504.400 --- guanylyl imidodiphosphate MeSH D13.695.667.454.525 --- 5-guanylic acid ...
Example 3. A mixture of 3.3 gm Chronoflex C(65D) (Lot# CTB-G25B-1234) dispersion containing 0.3 gm of Chronoflex C(65D) and 2.2 ... 3. The device of claim 1, which provides sustained release of the therapeutically active form of A for a period of at least 24 ... 3, which shows the total cumulative release of TC-112 from PVA coated glass plates. The slope of the curve demonstrates that TC ... Three (3) Stents, supplied by Guidant Corp, were coated then with the polymer /TC-32 solution by dipping and followed by air- ...
2.A.41.2.3. Pyrimidine-preferring nucleoside:Na+ symporter, CNT1 (Na+/nucleoside = 2)(transports uridine, gemcitabine and 5- ... 2.A.41.1.3. The purine nucleoside uptake transporter NupG (YxjA) (Johansen et al., 2003) ... Solute carrier family 28 member 3 (Concentrative Na+-nucleoside cotransporter 3) (CNT 3) (hCNT3). This protein is distinct from ... Broadly selective nucleoside:Na+ cotransporter, hfCNT (transports uridine, thymidine, inosine, 3-azido-3deoxythymidine, 23 ...
3-DAU pretreatment for 2 hours increases inhibitory activity of Ara-C 35 fold. The in vivo studies using ATS-mouse xenografts ... Two chemotherapeutic combinations, 2′-deoxycoformycin (DCF) plus 8-azaadenosine (8-Aza-Ado) or formycin and 3-deazauridine (3- ... 3). Fiber dosimetry and biologic markers of response will be compared following intrapleural injection and inhalation of ... 3) To determine whether asbestos-activated macrophages stimulate invasion of preneoplastic and neoplastic mesothelial cells; 4 ...
GENOMICS 2006;87(3):410-6. N-1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. Hernandez ... 3 -[4-Aryl-(1,2,3-triazol-1-yl)]-3 -deoxythymidine Analogues as Potent and Selective Inhibitors of Human Mitochondrial ... GENOMICS 1996;38(3):450-1. Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human ... Reviews on recent clinical trials 2006;1(3):185-92. New ultrasensitive P-32-postlabelling method for the analysis of 3,N-4- ...
3. Completed. Treatment. Infant, Low Birth Weight / Infant, Small for Gestational Age / Infants, Premature / Newborn Infants / ... 3. Completed. Treatment. Sickle Cell Disorders / Sickle ß0-Thalassemia. 1. 3. Recruiting. Treatment. Acute Kidney Injury (AKI) ... 3. Completed. Treatment. Critical Illness / Infection Complication / Inflammatory Reaction / Multiple Organ Failure / Nutrition ... 2, 3. Terminated. Treatment. Critical Illness / Respiratory Insufficiency / Sepsis. 1. 3. Active Not Recruiting. Supportive ...
3.. Herbst KD, Corder MP, Justice GR: Successful Therapy with Methotrexate of a Multicentric Mixed Lymphoma of the Central ... Stewart DJ, Benvenuto JA, Leavens M, Hall SW, Benjamin RS, Plunkett W, McCredie KD, Burgess MA, Loo TL: Penetration of 3- ... Deazauridine into Human Brain, Intracerebral Tumor, and Cerebrospinal Fluid. Cancer Research 39: 4119-4122, 1979PubMedGoogle ... The other 5 patients all had rapid marked shrinkage of tumor, but 3 developed progression or appearance of meningeal disease. ...
2004;20(3):109-112. [PubMed]. [175] Martin RE, Henry RI, Abbey JL, Clements JD, Kirk K. Genome Biol. 2005;6(3) art. no.-R26. [ ... 2004;3(2):245-254. [PMC free article] [PubMed]. [200] De Koning HP, Al-Salabi MI, Cohen AM, Coombs GH, Wastling JM. Int. J. ... 1996;3(10):881-887. [PubMed]. [234] Heroux A, White EL, Ross LJ, Kuzin AP, Borhani DW. Structure. 2000;8(12):1309-1318. [PubMed ... 2002;13(3):167-172. [PubMed]. [253] Rubin H, Salem JS, Li LS, Yang FD, Mama S, Wang ZM, Fisher A, Hamann CS, Cooperman BS. Proc ...
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase ( ...
ethyl-β-carboline-3-carboxylate Antagonists Prostaglandins PGE1, PGE2, PGI2 Anticonvulsants hydantoins such as phenytoin, ... cytarabine), 3-deazaguanine, dihydro-5-azacytidine, tiazofurin, sangivamycin, Ara-A (vitarabine), 6-MMPR, PCNU, FENU, HENU, ... 24 (3): 356-363.. *Haspel, H. C., Stephenson, K. N., Davies-Hill, T., El-Barbary, A., Lobo, J. F., Croxen, R. L., Mougrabi, W ... Berl) 147(3):217-249 (1999).. *Wang et al., "Conjugation patterns of endogenous plasma catecholamines in human and rat," J. Lab ...
Yi-Dong Hong1,2,*, Jian Zhang3,*, Ming Zhuang1,*, Wei Li4, Puy-Uan Wu5, Ru-Tian Li5, Nan Hu1, Bao-Xiang Bian1, Zi-Yan Song1 and ... Figure 3: MKN45 (A) and MKN28 (B) cells were treated with Rhodamine-B-loaded NPs and TNPs, respectively. Fluorescent signals ... 3. Ebert MP, Tänzer M, Balluff B, Burgermeister E, Kretzschmar AK, Hughes DJ, Tetzner R, Lofton-Day C, Rosenberg R, Reinacher- ... 2013; 5:3.. 22. Lirk P, Berger R, Hollmann MW, Fiegl H. Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid ...
The addition of soluble STC-1 to MDA-MB-231 cultures resulted in the activation of the phosphoinositide 3-kinase (PI3K)/Akt ... Intracisternal administration of mesulergine (0.03, 0.3 and 3 mg/kg) did not produce any change in blood pressure. One well- ... vinacea, while the three hydroxyl groups (OH-3, -4, and -6) are necessary for the activity of the A. ... Negative ion fast atom bombardment and collision-induced dissociation mass spectrometry of the 2-, 3-, 4- and 6-deoxy ...
Phase I--II study of 3-deazauridine in adults with acute leukemia. Paromomycin, differing from neomycin by only one amino group ... In acetonitrile, 2-HEAQ underwent efficient intersystem crossing to the triplet excited state ((2-HEAQ)(3)). The right to a ...
... deazauridine, dexrazoxane, dianhydrogalactitol, diaziquone, dibromodulcitol, didemnin B, diethyldithiocarbamate, ... 3(. a), magnified 2000 times.. FIG. 4. shows three stent surfaces after they have undergone a whole blood test; Stent A is the ... 3(. a) and 3(b), respectively.. EXAMPLE 5. Blood Compatibility of the Multi-Layer Coated Stent-Whole Blood Test. Three ... 3(. a) is an SEM image of a stent surface coated by a spray-coating method, magnified 50 times. ...
The early response (1 to 3 h) of the macrophage cell line ANA-1 to H-Candida results in enhanced tumor necrosis factor (TNF) ... The aim of this study was to report on the outcomes of complex displaced 3- and 4-part fractures of the proximal humerus ... The uridine analog 3-deazauridine has been given to 19 patients in a phase I and pharmacokinetic study. ... while those in the FGFR-3 gene may cause isolated unicoronal synostosis. An anatomical substrate for integration among ...
A 3-fold purification has been reached with a 0.56 % recovery. The purification scheme involved ammonium sulfate precipitation ... The substrate specificity of the enzyme was investigated using 2-deoxyinosine, allopurinol riboside, 3-deazauridine, and ...
... deazauridine, anguidine, PALA, aphidicolin, L-alanosine, maytansine, DQ-1, camptothecin, cremophor EL, homoharringtonine, ... Table 3 lists the results at 0, 1, 2, 3, and 4 hours after addition of organisms. TABLE 3. ... One hundred and fifty microliters of a suspension of E. coli (ATCC #11775) was added to the wells to yield about 3 107 CFU/ml. ... 3, 1993, which issued as U.S. Pat. No. 5,567,598 on Oct. 22, 1996, and which is continuation of U.S. Ser. No. 07/687,359, filed ...
3. To construct databases (chemical libraries) that allow efficacious handling of the data generated and extraction of ... We perform first-rate pre-clinical (7 Tesla Bruker) and clinical (3 Tesla Siemens) research using structural and functional MRI ... This invention concerns new family of C3-arylated-3-deazauridine with potent anti-HSV activities and negligible cytotoxicity ... The laboratory is equipped with 3 high resolution gamma spectrometry detectors, 1 Nal gamma spectrometry detector for measuring ...
Biologija 3:10-12. * Semėnaitė, R., R. Gasparavičiūtė, R. Duran, S. Precigou, L. Marcinkevičienė, I. Bachmatova, and R. Meškys. ... Biologija 3:13-15. * Ger, M., V. Tunaitis, and M. Valius. 2003. Elucidation of the complex formation between Nck-α, RasGTPase ... Biologija 3:53-55. * Klausa, V., L. Piešinienė, J. Staniulis, and R. Nivinskas. 2003. Abundance of T4-type bacteriophages in ... Biologija 3:3-6. * Piešinienė, L., A. Zajančkauskaitė, L. Truncaitė, and R. Nivinskas. 2003. Analysis of sequence-specific ...
1995;22:3-10.Google Scholar. *. Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, Schramm H, Fahlke J, Zuelke C ... 3). Previously, Flores et al. described that p53 requires TAp73 and/or TAp63 for DNA damage-induced cell death, whereas TAp73 ... Meijer A, Kruyt FA, van der Zee AG, Hollema H, Le P, ten Hoor KA, Groothuis GM, Quax WJ, de Vries EG, de Jong S. Nutlin-3 ... 3 RUNX2 prohibits pro-apoptotic TAp63 in p53-mutated pancreatic cancer cells. RUNX2 collaborates with mutant p53 to inhibitpro- ...
  • Negative ion fast atom bombardment and collision-induced dissociation mass spectrometry of the 2-, 3-, 4- and 6-deoxy derivatives from methyl beta-D-galactopyranoside and related compounds. (statescale.cf)
  • We perform first-rate pre-clinical (7 Tesla Bruker) and clinical (3 Tesla Siemens) research using structural and functional MRI, resonance spectroscopy, molecular imaging, image processing among other MR techniques. (transbio-sudoe.eu)
  • Often after 3-5 years of treatment patients reportedly develop complex dose-related unpredictable response fluctuations leading to a progressive decrease in therapeutic efficacy and also possible onset of serious side effects such as abnormal involuntary movements, end-of-dose deterioration and abrupt near instantaneous on-off changes in patient disability. (justia.com)
  • For instance, hypermethylation of the transcription factor AP-2 epsilon (TFAP2E) affects the therapeutic efficacy of 5-FU based chemotherapy in colorectal cancer [ 3 ] and GC [ 4 ]. (oncotarget.com)
  • 2003. Synthesis of 1-(9-alkyl-9H-carbazol-3-yl)-4-carboxy-2-pyrrolidinones. (vu.lt)
  • 3. The device of claim 1, which provides sustained release of the therapeutically active form of A for a period of at least 24 hours, and, over the period of release, the concentration of the prodrug eluting from polymer is less than 10% of the concentration of the therapeutically active form of A. 4. (freepatentsonline.com)
  • The hypermethylation decreases TFAP2E expression and consequently increases expression of its downstream target dickkopf homolog 4 protein (DKK4), which is related to 5-FU resistance [ 3 , 4 ]. (oncotarget.com)
  • vinacea, while the three hydroxyl groups (OH-3, -4, and -6) are necessary for the activity of the A. (statescale.cf)
  • For AML 3 cells, the com bination of five AZA CdR, GSK 126, and TSA showed a similar synergistic interaction in a colony assay because the triple blend that contained DZNep. (bossforum.net)
  • Solute carrier family 28 member 3 (Concentrative Na + -nucleoside cotransporter 3) (CNT 3) (hCNT3). (tcdb.org)
  • The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. (healthmatics.info)