Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.
Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.
A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53).
A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.
Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.
A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the CAROTID BODY; GLOMUS JUGULARE; GLOMUS TYMPANICUM; AORTIC BODIES; and the female genital tract. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. (From Stedman, 27th ed)
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
Alcohol oxidoreductases with substrate specificity for LACTIC ACID.
Enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of NAD+ or NADP+ to yield estrone and NADH or NADPH. The 17-hydroxyl group can be in the alpha- or beta-configuration. EC 1.1.1.62
A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.
Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. EC 2.8.2.
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)
A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The rate dynamics in chemical or physical systems.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.
Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.
An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha-hydroxysteroids, such as from PROGESTERONE to 20-ALPHA-DIHYDROPROGESTERONE.
An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.
An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.
A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.
Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
A flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield dihydrolipoamide and NAD+. The enzyme is a component of several MULTIENZYME COMPLEXES.
Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.
An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of NAD. It also acts on D-glucitol to form D-fructose. It also acts on other closely related sugar alcohols to form the corresponding sugar. EC 1.1.1.14
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A glucose dehydrogenase that catalyzes the oxidation of beta-D-glucose to form D-glucono-1,5-lactone, using NAD as well as NADP as a coenzyme.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Oxidoreductases that are specific for ALDEHYDES.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.47; EC 1.1.1.118; EC 1.1.1.119 and EC 1.1.99.10.
An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.
Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.
Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS.
A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.
An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.
A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. It forms a complex with ELECTRON TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE.
Flavoproteins that catalyze reversibly the reduction of carbon dioxide to formate. Many compounds can act as acceptors, but the only physiologically active acceptor is NAD. The enzymes are active in the fermentation of sugars and other compounds to carbon dioxide and are the key enzymes in obtaining energy when bacteria are grown on formate as the main carbon source. They have been purified from bovine blood. EC 1.2.1.2.
An enzyme that catalyzes the oxidation of XANTHINE in the presence of NAD+ to form URIC ACID and NADH. It acts also on a variety of other purines and aldehydes.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
A ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO2. The enzyme requires THIAMINE DIPHOSPHATE as a cofactor. Defects in genes that code for subunits of the enzyme are a cause of MAPLE SYRUP URINE DISEASE. The enzyme was formerly classified as EC 1.2.4.3.
Proteins prepared by recombinant DNA technology.
Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis.
The E1 component of the multienzyme PYRUVATE DEHYDROGENASE COMPLEX. It is composed of 2 alpha subunits (pyruvate dehydrogenase E1 alpha subunit) and 2 beta subunits (pyruvate dehydrogenase E1 beta subunit).
Oxidoreductases that are specific for KETONES.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Inorganic salts of sulfuric acid.
An oxidoreductase involved in pyrimidine base degradation. It catalyzes the catabolism of THYMINE; URACIL and the chemotherapeutic drug, 5-FLUOROURACIL.
An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC 1.1.1.22.
Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.
A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a ... Khanna M, Qin KN, Wang RW, Cheng KC (Aug 1995). "Substrate specificity, gene structure, and tissue-specific distribution of ... Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to ... "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional ...
In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific). As of late 2007, 11 ... Tomkins GM (1956). "A mammalian 3alpha-hydroxysteroid dehydrogenase". J. Biol. Chem. 218 (1): 437-447. PMID 13278351. Biology ... more specifically it is part of the group of hydroxysteroid dehydrogenases. ...
Marcus PI; Talalay P (1956). "Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases". J. Biol. Chem. 218 ... In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 1.1.1.50) is an enzyme that catalyzes the chemical ... B-specific). Other names in common use include hydroxyprostaglandin dehydrogenase, 3alpha-hydroxysteroid oxidoreductase, and ... more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha- ...
HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene". ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver". Pharmacogenetics. 9 (6): 763-71. doi:10.1097/00008571- ... "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells. 5 (2): ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...
Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R (Aug 2003). "Human 20alpha-hydroxysteroid dehydrogenase: ... "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid ... O'connor T, Ireland LS, Harrison DJ, Hayes JD (Oct 1999). "Major differences exist in the function and tissue-specific ... Zhang Y, Dufort I, Rheault P, Luu-The V (Oct 2000). "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". Journal ...
"11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response". Endocrine Reviews. 25 (5): ... 11 alpha-Hydroxyprogesterone (11 alpha OH-P) was an order of magnitude more potent a competitive inhibitor of the 11 beta HSD-2 ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of ...
... in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J ... It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype ... that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3 ... The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM- ...
Moghrabi N, Head JR, Andersson S (Nov 1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in ... variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen ... 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in ... a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity". The Journal of Biological Chemistry. 268 (17): ...
In accordance, 11α- and 11β-hydroxyprogesterone are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... However, formebolone was found to be a very weak inhibitor of 11β-HSD type 2, although this specific isoenzyme is responsible ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...
... formed by the 20α-hydroxysteroid dehydrogenases (20α-HSDs) AKR1C1, AKR1C2, and AKR1C3 and the 17β-hydroxysteroid dehydrogenase ... Nowak FV (April 2002). "Distribution and metabolism of 20 alpha-hydroxylated progestins in the female rat". J. Steroid Biochem ... 4-. ISBN 978-1-4200-7745-2. Marianne J. Legato (29 October 2009). Principles of Gender-Specific Medicine. Academic Press. pp. ... Casey ML, MacDonald PC, Andersson S (November 1994). "17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and ...
Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene. Dlx3 is a crucial regulator of hair follicle ... 7 (3): 563-9. doi:10.1093/hmg/7.3.563. PMID 9467018. Roberson MS, Meermann S, Morasso MI, et al. (2001). "A role for the ... 38 (3): 314-24. doi:10.1006/geno.1996.0634. PMID 8975708. Price JA, Bowden DW, Wright JT, et al. (1998). "Identification of a ... 145 (3): 1096-105. doi:10.1210/en.2003-0777. PMID 14670999. Haldeman RJ, Cooper LF, Hart TC, et al. (2005). "Increased bone ...
"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine Reviews. 25 (5 ... Cortisol is also metabolized into 5-alpha tetrahydrocortisol (5-alpha THF) and 5-beta tetrahydrocortisol (5-beta THF), ... Cortisol is metabolized by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: 11- ... and tumor necrosis factor alpha (TNF-alpha) by antigen-presenting cells (APCs) and T helper cells (Th1 cells), but upregulates ...
... factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase ... is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes". The Journal of Biological Chemistry ... "Entrez Gene: TEAD3 TEA domain family member 3". Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding ...
20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor". Structure. 2 (10): 973-80. doi:10.1016/S0969- ... has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains. ... Glucose/ribitol dehydrogenase InterPro: IPR002347 Insect alcohol dehydrogenase family InterPro: IPR002424 2,3-dihydro-2,3- ... alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases ...
"Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities". Life Sciences. 68 (7): 751-61 ... The gene has nine coding exons and a number of alternative non-coding first exons that regulate tissue specific expression. ... Om AS, Chung KW (April 1996). "Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen ... Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn ...
"Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities". Life Sciences. 68 (7): 751-61 ... Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn ... Om AS, Chung KW (April 1996). "Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen ... Simpson ER (February 2004). "Aromatase: biologic relevance of tissue-specific expression". Seminars in Reproductive Medicine. ...
The reductive pathways are by 11β-hydroxysteroid dehydrogenase type 1 in the liver and AKR7A2/AKR7A3 in the intestine leading ... The alpha position adjacent to the ketone is first brominated followed by nucleophilic displacement of the resulting alpha- ... Urquhart DM, Hoving JL, Assendelft WW, Roland M, van Tulder MW (2008). Urquhart DM (ed.). "Antidepressants for non-specific low ... Based on studies indicating that bupropion lowers the level of the inflammatory mediator TNF-alpha, there have been suggestions ...
Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of ... although this specific isoenzyme of 11β-HSD is responsible for the inactivation of glucocorticoids rather than their production ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...
Hydroxysteroid dehydrogenase. ... Other specific CYP functions[edit]. Steroid hormones[edit]. ... CYP51A1 (lanosterol 14-alpha demethylase) P450s in other species[edit]. Animals[edit]. Many animals have as many or more CYP ... The specific problem is: broken links; fragmented paragraph. Please help improve this section if you can. (September 2016) ( ... 7-alpha hydroxylation of 24-hydroxycholesterol. 1 subfamily, 1 gene. CYP39A1 CYP46. cholesterol 24-hydroxylase. 1 subfamily, 1 ...
... include autosomal recessive disorders with mutations lowering the activity of the enzyme 11-beta-hydroxysteroid dehydrogenase ... Deficiency of 17-alpha-hydroxylase blocks the conversion of pregnenolone and progesterone to their 17-a-hydroxy forms leading ... In some cases, specific antihypertensive medications may be recommended. In Liddle's syndrome, ENaC-binding potassium-sparing ... Specific treatment of pseudohyperaldosteronism depends on the inciting cause. General management focuses on countering the ...
The gene has these neighbors on chromosome 9: HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide ... According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal ... and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID ... KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth ...
... specifically with local expression at the skin of reductive 17β-hydroxysteroid dehydrogenase, and oxidative 3α-hydroxysteroid ... 2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases". Adv. Urol. 2012: ... Specific substrates include testosterone, progesterone, androstenedione, epitestosterone, cortisol, aldosterone, and ... Wang J, Zhao S, Luo L, Li E, Li X, Zhao Z (2018). "5-alpha Reductase Inhibitors and risk of male breast cancer: a systematic ...
... and then finally converted to testosterone by 17β-hydroxysteroid dehydrogenase (HSD17B). The onset of puberty is controlled by ... labeled alpha- and beta- subunits) that are non-covalently associated: The alpha subunits of LH, FSH, TSH, and hCG are ... LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is responsible for the specificity ... The gene for the alpha subunit is located on chromosome 6q12.21. The luteinizing hormone beta subunit gene is localized in the ...
Hydroxysteroid dehydrogenase. ... Other specific CYP functionsEdit. Steroid hormonesEdit. ... 7-alpha hydroxylation of 24-hydroxycholesterol. 1 subfamily, 1 gene. CYP39A1 CYP46. cholesterol 24-hydroxylase. 1 subfamily, 1 ... The specific problem is: broken links; fragmented paragraph. Please help improve this section if you can. (September 2016) ( ... steroid biosynthesis, 17-alpha hydroxylase. 1 subfamily, 1 gene. CYP17A1 CYP19. steroid biosynthesis: aromatase synthesizes ...
Her team was the first to publish mutations on the 11β-hydroxysteroid dehydrogenase type 2 enzyme (encoded by the HSD11B2 gene ... President's Council of Cornell Women Alpha Omega Alpha, University of Pennsylvania School of Medicine New York Practitioner's ... to study specific steroid hormone production during infancy, childhood and adolescence.[citation needed] In 1964, New was ... New was first to identify the mild form with specific molecular mutations. New has received numerous honors, including: IPSEN ...
Hepatic metabolism is mediated by 11 beta-hydroxysteroid dehydrogenases (11[beta]-HSD) and 20-ketosteroid reductases. ... A specific example is the deacetylation by histone deacetylase 2 (HDACe) was necessary for transrepression of NF-κB. The ... alpha]-hydroxymethylprednisolone. As stated previously, the primary use of methylprednisolone is to suppress inflammatory and ... Specific immune functions effected by this process are cytokinesis, migration, phagocytosis, antigen processing and presenting ...
Estrone can also be converted by 17β-hydroxysteroid dehydrogenases into the more potent estrogen estradiol. E1S levels are much ... Instead, estrone sulfate is transported into cells in a tissue-specific manner by active transport via organic-anion- ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ... For this reason, enzyme inhibitors of steroid sulfatase and 17β-hydroxysteroid dehydrogenase and inhibitors of OATPs, which ...
20 lyase deficiency 17β-hydroxysteroid dehydrogenase deficiency 5α-reductase deficiency Androgen excess in 46,XX individuals: ... Taneja SS, Ha S, Swenson NK, Huang HY, Lee P, Melamed J, Shapiro E, Garabedian MJ, Logan SK (December 2005). "Cell-specific ... Testosterone is converted into dihydrotestosterone by the 5-alpha reductase enzyme. If this enzyme is absent or deficient, then ... When used to screen for a specific genetic sequence, its main advantage is that it avoids selective pregnancy termination, as ...
The conversion of androstenedione to testosterone is catalyzed by 17β-hydroxysteroid dehydrogenase (17β-HSD), whereas the ... The estrogen:ER complex binds to specific DNA sequences called a hormone response element to activate the transcription of ... 2004). "Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells". Genome Biology. 5 (9): ... estradiol is dehydrogenated by 17β-hydroxysteroid dehydrogenase into the much less potent estrogen estrone. These reactions ...
Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause ... PCOS has also been associated with a specific FMR1(英语:FMR1) sub-genotype. The research suggests that women with heterozygous- ... Fukuoka M, Yasuda K, Fujiwara H, Kanzaki H, Mori T. Interactions between interferon gamma, tumour necrosis factor alpha, and ... 原始内容存档于3 March 2015).. *^ 4.0 4.1 4.2 4.3 4.4 4.5 Polycystic Ovary Syndrome (PCOS): Condition Information. US Department of ...
17β-Hydroxysteroid dehydrogenase deficiency. *Aromatase excess syndrome. Androgen receptor. *Androgen insensitivity syndrome ... EIS results when the function of the estrogen receptor alpha (ERα) is impaired. The ERα protein (pictured) mediates most of the ... Osteocalcin and bone-specific alkaline phosphatase levels were both substantially elevated (18.7-21.6 ng/mL and 33.3-35.9 ng/mL ... 20 (3): 358-417. doi:10.1210/edrv.20.3.0370. PMID 10368776.. *^ a b c Hill RA, Boon WC (2009). "Estrogens, brain, and behavior ...
... involves a defect in the gene for 11β-hydroxysteroid dehydrogenase, an enzyme that normally inactivates circulating cortisol to ... The specific mechanism involved is increased release of the "stress hormones", epinephrine (adrenaline) and norepinephrine ... 17 alpha-hydroxylase deficiency causes an inability to produce cortisol. Instead, extremely high levels of the precursor ... by causing inhibition of the 11β-hydroxysteroid dehydrogenase enzyme and likewise leading to secondary apparent ...
There is currently no specific treatment for this condition.. In the case of lactate dehydrogenase-B deficiency, mutations to ... crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD". J Mol ... Phosphogluconate dehydrogenase. *Sorbitol dehydrogenase. *Hydroxysteroid dehydrogenase: 3β *3β-HSD. *NSDHL ... lactate dehydrogenase A. (subunit M). Human lactate dehydrogenase M4 (the isoenzyme found in skeletal muscle). From PDB: 1I10​. ...
17β-hydroxysteroid dehydrogenase deficiency. *aromatase excess syndrome. *Androgen receptor (Androgen insensitivity syndrome) ... Urinalysis demonstrates a dilute urine with a low specific gravity. Urine osmolarity and electrolyte levels are typically low. ... Alpha-thalassemia mental retardation syndrome. *Siderius X-linked mental retardation syndrome. *Eye disorders: Color blindness ... 3 per 100,000 per year[4]. Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased ...
... which regulates the expression of the enzyme 17β-hydroxysteroid dehydrogenase that is used to convert androstenedione, the ... The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids in human but 96 amino acids in almost all ... LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is responsible for the specificity ... In contrast to the alpha gene activity, beta LH subunit gene activity is restricted to the pituitary gonadotropic cells. It is ...
Though the specific cause of the reduced production is not clear, it is believed that the death of medium-sized motor neurons ... The full name of B transferase is alpha 1-3-galactosyltransferase, and its function in the cell is to add a galactose molecule ... Herbst EA, MacPherson RE, LeBlanc PJ, Roy BD, Jeoung NH, Harris RA, Peters SJ (Jan 2014). "Pyruvate dehydrogenase kinase-4 ... Due to this, alcohol sulfotransferase is also known by several other names including "hydroxysteroid sulfotransferase," " ...
Blackburn CM, Childs DS (March 1959). "Use of 2 alpha-methyl androstan-17 beta-ol, 3-one (2-methyl dihydrotestosterone) in the ... phase III clinical studies for cachexia but development was ultimately never completed for these indications in these specific ... 978-1-4757-2085-3. .. *^ a b c d e f g h i j Llewellyn W (2009). Anabolics. Molecular Nutrition Llc. pp. 19, 163. ISBN 978- ... 978-0-8155-1856-3. .. *^ a b c d e f g Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, ...
... specifically with local expression at the skin of reductive 17β-hydroxysteroid dehydrogenase, and oxidative 3α-hydroxysteroid ... Trost L, Saitz TR, Hellstrom WJ (2013). "Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review". Sex Med Rev. 1 ... Specific substrates include testosterone, progesterone, androstenedione, epitestosterone, cortisol, aldosterone, and ... "FDA Alert: 5-alpha reductase inhibitors (5-ARIs): Label Change - Increased Risk of Prostate Cancer". Drugs.com. Retrieved 2014- ...
In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17β-hydroxysteroid dehydrogenase to yield ... Randall VA (Apr 1994). "Role of 5 alpha-reductase in health and disease". Baillière's Clinical Endocrinology and Metabolism. 8 ... testosterone is supplied to target tissues in the blood where much of it is transported bound to a specific plasma protein, sex ... which regulates the expression of 17β-hydroxysteroid dehydrogenase.[124]. The amount of testosterone synthesized is regulated ...
The conversion of androstenedione to testosterone is catalyzed by 17β-hydroxysteroid dehydrogenase (17β-HSD), whereas the ... The estrogen:ER complex binds to specific DNA sequences called a hormone response element to activate the transcription of ... "DHEA metabolites activate estrogen receptors alpha and beta". Steroids. 78 (1): 15-25. doi:10.1016/j.steroids.2012.10.002. PMC ... estradiol is dehydrogenated by 17β-hydroxysteroid dehydrogenase into the much less potent estrogen estrone. These reactions ...
17β-hydroxysteroid dehydrogenase deficiency. *aromatase excess syndrome. *Androgen receptor (Androgen insensitivity syndrome) ... Damage to a specific nerve of the thoracic or lumbar spinal nerves can occur and may lead to painful syndromes that mimic a ... Amyotrophy or radiculopathy such as proximal diabetic neuropathy, affecting a specific pattern of nerves ... Multiple lesions, affecting nerves that don't follow a specific pattern, also called "mononeuritis multiplex" ...
Mutzebaugh C (1998). "Does the choice of alpha-AAS really make a difference?". HIV Hotline. 8 (5-6): 10-1. PMID 11366379.. ... Child-specific: premature epiphyseal closure and associated short stature, precocious puberty in boys, delayed puberty and ... Female-specific side effects include increases in body hair, permanent deepening of the voice, enlarged clitoris, and temporary ... Male-specific: spontaneous erections, nocturnal emissions, priapism, erectile dysfunction, gynecomastia (mostly only with ...
Aromatase and 17beta-hydroxysteroid dehydrogenase are aberrantly expressed in fibroids, indicating that fibroids can convert ... Specific mutations of the MED12 protein have been noted in 70 percent of fibroids.[28] ... and promotes survival through up-regulating Bcl-2 expression and down-regulating TNF-alpha. Progesterone is believed to ... 10 (3): 207-220. doi:10.1093/humupd/dmh019. PMID 15140868.. *^ a b Yen-Ping Ho J, Man WC, Wen Y, Polan ML, Shih-Chu Ho E, Chen ...
Aspartate-semialdehyde dehydrogenase. *Asprosin. *Ataxin 7. *ATCase/OTCase family. *Atg1. *ATG3. *ATP synthase alpha/beta ... Brain-specific angiogenesis inhibitor. *Branched chain amino acid-cation symporter. *Brassinosteroid insensitive-1 ...
... estrone is also formed reversibly from estradiol by the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD) in various tissues, ... It is a white, odorless, solid crystalline powder, with a melting point of 254.5 °C (490 °F) and a specific gravity of 1.23. ... "Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta". Biochemical ... 511-. ISBN 978-3-642-96158-8. E. A. Doisy and A. Butenandt reported almost at the same time on the isolation of an estrogen- ...
RAG1 Alpha-2-plasmin inhibitor deficiency; 262850; PLI Alpha-ketoglutarate dehydrogenase deficiency; 203740; OGDH Alpha- ... CYP17A1 17-beta-hydroxysteroid dehydrogenase X deficiency; 300438; HSD17B10 2-methylbutyrylglycinuria; 610006; ACADSB 3- ... KIAA0196 Specific granule deficiency; 245480; CEBPE Speech-language disorder-1; 602081; FOXP2 Spherocytosis, hereditary, type 5 ... PC Pyruvate dehydrogenase deficiency; 312170; PDHA1 Pyruvate dehydrogenase E2 deficiency; 245348; DLAT Pyruvate dehydrogenase ...
2003). "Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact ... 5-alpha reductase inhibitors (such as finasteride and dutasteride) may also be used; they work by blocking the conversion of ... PCOS has also been associated with a specific FMR1 sub-genotype. The research suggests that women with heterozygous-normal/low ... tumour necrosis factor alpha, and interleukin-1 in modulating progesterone and oestradiol production by human luteinized ...
Rosler, A (August 2006). "17 beta-hydroxysteroid dehydrogenase 3 deficiency in the Mediterranean population". Pediatric ... The Centre provide information about specific countries, and maintain a list of Genomic diseases. Specific rare autosomal ... glucose-6-phosphate dehydrogenase deficiency, alpha-thalassemia, molecular characterization, recessive osteoperosis, ... Many of the genetic disorders specific to Arabs are located on HLA segment on chromosome 6. These same segment mutations are ...
17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes ... H+ The human 17β-HSD1 isozyme is highly specific for estrogens over androgens whereas the rodent isozyme is less specific. ... "Molecular dissection of a cosmid from a gene-rich region in 17q21 and characterization of a candidate gene for alpha-N- ... "Entrez Gene: HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1". Saloniemi T, Jokela H, Strauss L, Pakarinen P, Poutanen M (2012 ...
Marcus PI; Talalay P (1956). "Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases". J. Biol. Chem. 218 ... In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 1.1.1.50) is an enzyme that catalyzes the chemical ... B-specific). Other names in common use include hydroxyprostaglandin dehydrogenase, 3alpha-hydroxysteroid oxidoreductase, and ... more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha- ...
HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene". ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver". Pharmacogenetics. 9 (6): 763-71. doi:10.1097/00008571- ... "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells. 5 (2): ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...
ALPHA-HYDROXYSTEROID DEHYDROGENASE; RANDOMIZED CONTROLLED-TRIAL; KETO REDUCTASE SUPERFAMILY; PROGESTERONE-RECEPTOR GENE; TISSUE ... GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THE AKR1C1 GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL ... GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THE AKR1C1 GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL ... In summary, this is the first evidence for the gender-specific implication of the AKR1C1 gene in the expression of anticipatory ...
AdhD alcohol dehydrogenase from the thermophile Pyrococcus furiosus is one of the enzymes being engineered with these features ... possesses a parallel alpha-beta structural motif of the found in all enzymes in the aldo-keto reductase(AKR) family. ... The interactions within the active site and testosterone are very specific because of the structure and positioning of the ... As with the previous protein, pink and blue highlight the alpha and beta barrel structure common to AKRs. The cofactor NAD+ is ...
... alpha--,beta)-hydroxysteroid epimerase were significantly higher in Om fat. 3Alpha/beta-HSD activity was mainly detected in the ... Experiments with isoform-specific AKR1C inhibitors in preadipocytes showed that AKR1C2 inhibition significantly decreased ... hydroxysteroid dehydrogenase type 2) and 3( ... 2006 Dec;191(3):637-49. Research Support, Non-U.S. Govt ... J Endocrinol. 2006 Dec;191(3):637-49.. Androgen inactivation and steroid-converting enzyme expression in abdominal adipose ...
Genes are pieces of DNA, and most genes contain the information for making a specific protein.gene (26), the alpha-globin The ... alcohol dehydrogenase (32), 3 alpha-hydroxysteroid dehydrogenases (33), apolipoprotein A-II (34), beta1,4-N- ... Genes are pieces of DNA, and most genes contain the information for making a specific protein.gene (36), Alpha-1 acid ... Properties of the mouse alpha-globin HS-26: relationship to HS-40, the major enhancer of human alpha-globin The functional and ...
Specific function:. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal ... 7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity. Gene Name:. CYP27A1. Uniprot ID:. Q02318 Molecular ... 7 alpha-Dihydroxy-5-cholestenoate or 7 alpha,26-Dihydroxy-4-cholesten-3-one through the actions of HSD3B7 (EC:1.1.1.181) or ... 7 alpha-Dihydroxy-5-cholestenoate + NAD → 7 alpha-Hydroxy-3-oxo-4-cholestenoate + NADH + Hydrogen Ion. details. ...
The enzyme 20 alpha-hydroxysteroid dehydrogenase (20 alpha SDH) has previously been shown to be a specific enzyme marker of ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ...
Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to ... androsterone dehydrogenase (B-specific) activity. oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver. Pharmacogenetics. 1999 Dec;9(6):763-71. [PubMed:10634139 ] ... Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. Genes Cells. 2000 Feb;5( ...
Specific function:. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal ... 26-hydroxysteroid. *Dihydroxy bile acid, alcohol, or derivatives. *3-oxo-delta-4-steroid ... 7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity. Gene Name:. CYP27A1. Uniprot ID:. Q02318 Molecular ... 7 alpha,26-Dihydroxy-4-cholesten-3-one. Description. 7 alpha,26-Dihydroxy-4-cholesten-3-one is involved in primary bile acid ...
B-Specific). Settore Scientifico Disciplinare: Settore BIO/13 - Biologia Applicata. Settore MED/13 - Endocrinologia. Settore ... To this purpose the 5 alpha-reductase activity has been evaluated in the sciatic nerve of the rat and compared to that present ... No studies have been performed up to now, in order to evaluate the possible presence of the 5 alpha-reductase activity in ... No age-related variations in the 5 alpha-reductase activity in the cerebral cortex and in the subcortical white matter have ...
World Health Organization, "46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency," in ICD ... Specific ICD codes Individual codes in the ICD-11-MMS and ICD-11 Foundation typically contain both a title and description. In ... World Health Organization, "46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency", in ICD-11 Foundation, ... and 17-beta-hydroxysteroid dehydrogenase 3 deficiency (17ß-HSD3) are notable. Each of these variations are associated with ...
... crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. ... Androsterone Dehydrogenase Activity * Androsterone Dehydrogenase (b Specific) Activity * Steroid Metabolic Process * ... Alpha Beta Alpha-Beta Barrel TIM Barrel NADP-dependent oxidoreductase B. 1afsB00. Alpha Beta Alpha-Beta Barrel TIM Barrel NADP- ... Alpha and beta proteins (a/b) TIM beta/alpha-barrel NAD(P)-linked oxidoreductase Aldo-keto reductases (NADP) 3-alpha- ...
... reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase ... Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Tyrosine-dependent ... Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Tyrosine-dependent ... Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain ...
3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha- ... 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido- ... hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)- ... 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, ...
A-specific) (substance). Code System Preferred Concept Name. 3-alpha-hydroxysteroid dehydrogenase (A-specific) (substance). ...
A-specific) activity. 0.000196426050335292. GO:0047115. trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity. ... testosterone 17-beta-dehydrogenase (NADP+) activity. 0.0395363767192471. GO:0047756. chondroitin 4-sulfotransferase activity. ... testosterone 17-beta-dehydrogenase activity. 0.046617552219066. GO:0030971. receptor tyrosine kinase binding. 0.046617552219066 ...
3alpha-hydroxysteroid dehydrogenase (B-specific). (EC 1.1.1.50). hydroxyprostaglandin dehydrogenase. (EC 1.1.1.50). 3alpha- ... Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H. ... 3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: biological significance, three-dimensional ... The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel ...
3alpha-Hydroxysteroid Dehydrogenase (B-specific). 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase. 5 alpha-3 ... 3alpha-Hydroxysteroid Dehydrogenase (B-specific) Dehydrogenase, 3 alpha-Hydroxysteroid Oxidoreductase, 3 alpha-Hydroxysteroid ... alpha-Hydroxysteroid Dehydrogenase. 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase. 5-DP-3 alpha-HSO. ... 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase - Narrower Concept UI. M0090285. Preferred term. 5 alpha- ...
Short-chain dehydrogenase/reductase retSDR8; AltName: Full=Tracheobronchial epithelial cell-specific retinol dehydrogenase; ... DHRS9_HUMAN RecName: Full=Dehydrogenase/reductase SDR family member 9; AltName: Full=3-alpha hydroxysteroid dehydrogenase; ... NADP-dependent retinol dehydrogenase/reductase; AltName: Full=RDH-E2; AltName: Full=RDHL; AltName: Full= ...
The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel ... Alpha Beta. 3-Layer(aba) Sandwich. Rossmann fold. NAD(P)-binding Rossmann-like Domain. 1fjhA00. ... Si-specific). pdb deposition date 2000-08-08. ... short chain dehydrogenase. A. PF13561 adh_short_C2. Enoyl-(Acyl ... "alpha-helix"). {{ pdb }} {{ chain }}. Filters - structure elements can be removed from the above chord diagram by clicking on ...
3-alpha hydroxysteroid dehydrogenase, type II)) for ICC/IF, IHC-P, IP, WB. Anti-AKR1C3 pAb (GTX104627) is tested in Human, Rat ... 2-diol dehydrogenase antibody, testosterone 17-beta-dehydrogenase 5 antibody, indanol dehydrogenase antibody, aldo-keto ... 1 mg/ml (Please refer to the vial label for the specific concentration). ... dihydrodiol dehydrogenase X antibody, chlordecone reductase homolog HAKRb antibody, 3-alpha-HSD type II, brain antibody, ...
Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to ... Specific activity is , 700 pmol/min/μg, and is defined as the amount of enzyme that catalyzes the reduction of 1.0 pmole 3- ... Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3- ...
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. J Clin Endocrinol Metab ... Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3 beta-hydroxysteroid dehydrogenase/ ... Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase/17, 20-lyase, and 3 beta- ... hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of ...
... alpha-hydroxysteroid dehydrogenase antibody. *3-alpha hydroxysteroid dehydrogenase antibody. *3-alpha-HSD antibody ... retinol dehydrogenase homolog antibody. *Retinol dehydrogenase, tracheobronchiol epithelail cell-specific antibody. *RETSDR8 ... 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone ... and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, ...
... hydroxysteroid [17-beta] dehydrogenase [HSD17B]3, HSD17B6, AKR1C2, AKR1C1, UGTB15, UGTB17, steroid-5-alpha-reductase, alpha ... 14-alpha Demethylase Inhibitors. Cytochrome P-450 Enzyme Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological ... To determine if specific AR splice variations correlate with PFS in response to ketoconazole. ... To determine the presence of specific prostate cancer-associated gene translocations in each sample of CRPC. ...
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase). 0.844. ... SMAD specific E3 ubiquitin protein ligase 2. 0.987. Yeast AKR1C2. aldo-keto reductase family 1, member C2 (dihydrodiol ... dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III). 0.958. ... The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or ...
20-alpha-Dihydroprogesterone 20-alpha-Hydroxysteroid Dehydrogenase 20-beta-Hydroxysteroid Dehydrogenase use Cortisone Reductase ... B-Specific) 3-Aminopropionic Acid use beta-Alanine ... alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha- ... 2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ...
  • Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase , 3α-hydroxysteroid dehydrogenase , and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene . (wikidoc.org)
  • A novel member of the short-chain dehydrogenase/reductase superfamily. (cbrc.jp)
  • The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family. (cbrc.jp)
  • This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. (genecards.org)
  • Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions. (ox.ac.uk)
  • Mutagenetic replacements of conserved residues within the active site of the short-chain dehydrogenase/reductase (SDR) superfamily were studied using prokaryotic 3 beta/17 beta-hydroxysteroid dehydrogenase (3 beta/17 beta-HSD) from Comamonas testosteroni as a model system. (ox.ac.uk)
  • The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific). (wikipedia.org)
  • Other names in common use include hydroxyprostaglandin dehydrogenase, 3alpha-hydroxysteroid oxidoreductase, and sterognost 3alpha. (wikipedia.org)
  • 1981. Purification of $20{\alpha}$ hydroxysteroid oxidoreductase from bovine fetal erythrocytes. (koreascience.or.kr)
  • In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 1.1.1.50) is an enzyme that catalyzes the chemical reaction androsterone + NAD(P)+ ⇌ {\displaystyle \rightleftharpoons } 5alpha-androstane-3,17-dione + NAD(P)H + H+ The 3 substrates of this enzyme are androsterone, NAD+, and NADP+, whereas its 4 products are 5alpha-androstane-3,17-dione, NADH, NADPH, and H+. (wikipedia.org)
  • Specific combination of compound heterozygous mutations in 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. (medlineplus.gov)
  • Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not appreciated until the discovery of 5 alpha-reductase type 2 deficiency in 1974. (hindawi.com)
  • Most people with 17-beta hydroxysteroid dehydrogenase 3 deficiency are born with external genitalia that appear typically female. (interconnect.support)
  • For example, congenital adrenal hyperplasia (SW CAH), Androgen Insensitivity Syndrome (AIS), 46, XY complete gonadal dysgenesis (Swyer syndrome), 46, XY partial gonadal dysgenesis, 5 alpha-reductase-3 deficiency (5 ARD deficiency) and 17beta-hydroxysteroid dehydrogenase-3 deficiency (17 BHSD deficiency), Hypospadias and Epispadias. (interseximmigrantsnetwork.org)
  • Coagulation deficiency appears to be non-specific in monosomy 13qter. (wickekltwiickeet6.gq)
  • Previous reports from this laboratory indicate that the 5 alpha-reductase, the enzyme which converts testosterone into its 'active' metabolite 5 alpha-androstan-17 beta-ol-3-one (dihydrotestosterone, DHT) is highly concentrated in the white matter structures of the CNS, which are mainly composed of myelinated fibers. (unimi.it)
  • Testosterone metabolism in peripheral nerves: presence of the 5 alpha-reductase-3 alpha-hydroxysteroid-dehydrogenase enzymatic system in the sciatic nerve of adult and aged rats / R. C. Melcangi, F. Celotti, M. Ballabio, A. Poletti, L. Martini. (unimi.it)
  • AKR1C3 metabolizes various androgen metabolites including 5a-dihydrotestosterone to 5a-androstane-3a,17b-diol, Delta 4 -androstene-3,17-dione to testosterone, androstanedione to 5a-dihydrotestosterone, androsterone to 5a-androstane-3a,17b-diol. (atlasgeneticsoncology.org)
  • 5-alpha-reductase is an enzyme converting weaker testosterone into more potent dihydrotestosterone (DHT). (interconnect.support)
  • Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step. (wickekltwiickeet6.gq)
  • 700 pmol/min/μg, and is defined as the amount of enzyme that catalyzes the reduction of 1.0 pmole 3-chlorobenzaldehyde in the presence of NADP per minute at pH 8.8 at 25°C. (abcam.com)
  • and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. (cbrc.jp)
  • A model on the regulation of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase expression in Comamonas testosteroni. (cbrc.jp)
  • Tyr155 and Lys159 in 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. (cbrc.jp)
  • Finally, in the Wnt signaling, RSPO3 was up-regulated unlike dickkopf homolog 3 (DKK3) which was in turn down-regulated. (bmj.com)
  • 3α-Hydroxysteroid dehydrogenase (3α-HSD or aldo-keto reductase family 1 member C4) is an enzyme that in humans is encoded by the AKR1C4 gene. (wikipedia.org)
  • In summary, this is the first evidence for the gender-specific implication of the AKR1C1 gene in the expression of anticipatory anxiety in PD. (uni-koeln.de)
  • To determine the presence of specific prostate cancer-associated gene translocations in each sample of CRPC. (clinicaltrials.gov)
  • Our analyses demonstrate the power of combining a statistically robust, comprehensive dataset and a functional network genomics approach to 1) identify and explore relationships between genes of known importance 2) identify novel candidate genes, and 3) observe the complex interplay between genes/gene products that function in seemingly different processes. (biomedcentral.com)
  • HSD3B7 (Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 7) is a Protein Coding gene. (genecards.org)
  • Thus, the endothelial cell-specific molecule-1 (ESM1), the Transmembrane-4-L-six-family-1 (TM4SF1), the 5'-Ectonucleotidase (NT5E) and the growth arrest-specific gene 6 (GAS6) were down-regulated by CS. (bmj.com)
  • In particular, Guanine nucleotide binding protein, alpha inhibiting 2 (GNAi2) and Amyloid β (A4) precursor protein (APP) were detected as stress-regulated genes, and together with other genes, seem to be integrated into stress-responsive pathways and gene networks in the PVN. (biomedcentral.com)
  • MethodsWe performed an association analysis of single nucleotide polymorphisms (SNPs) in five genes related to the neurosteroidal pathway with emphasis on progesterone and allopregnanolone biosynthesis (steroid-5-alpha-reductase 1A (SRD5A1), aldo-keto reductase family 1 C1-C3 (AKR1C1-AKR1C3) and translocator protein 18 kDA (TSPO) with panic disorder (PD) and dimensional anxiety in two German PD samples (cases N = 522, controls N = 1,115). (uni-koeln.de)
  • Genes are pieces of DNA, and most genes contain the information for making a specific protein. (godandscience.org)
  • This protein is an enzyme, which means that it helps specific biochemical reactions take place. (medlineplus.gov)
  • The protein has two separate regions (domains) with enzyme activity, called the hydratase and dehydrogenase domains. (medlineplus.gov)
  • Glucose chemotaxis is affected in specific TRPV subunit allele mutants: ocr-2(vs29) and osm-9(yz6), serotonin receptor mutants: ser-1(ok345) and mod-1(ok103), and G-alpha protein mutant: gpa-10(pk362). (unt.edu)
  • The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. (genecards.org)
  • Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. (genecards.org)
  • The interferon alpha-inductible protein 6 (IFI6) was the most up-regulated. (bmj.com)
  • We also identified the hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), the cathepsin K (CTSK), the chemokine (C-X-C motif) ligand 1 (CXCL1) and the EBV-induced G-protein coupled receptor 2 (EBI2). (bmj.com)
  • On the other hand, a T12S substitution yields a protein with unaltered catalytic constants for both reactions, revealing that a specific hydrogen bond is critical for the dehydrogenase activity. (ox.ac.uk)
  • It appears that the binding of NAD+ to the protein is influenced by local structural changes involving strand beta D and turn beta A to alpha B. (ox.ac.uk)
  • Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis. (wikipathways.org)
  • 1994. Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression. (koreascience.or.kr)
  • It is also known to catalyze the reversible conversion of 3α-androstanediol (5α-androstane-3α,17β-diol) to dihydrotestosterone (DHT, 5α-androstan-17β-ol-3-one) and vice versa. (wikipedia.org)
  • Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). (hmdb.ca)
  • A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. (bvsalud.org)
  • Intracellular T is converted to dihydrotestosterone (DHT), the preferred ligand for androgen receptor (AR) transactivation, by the enzyme 5 alpha-reductase (5 α -R). Upon ligand binding and transactivation, the DHT-AR complex translocates from cytoplasm to nucleus and activates the transcription of certain genes (the androgen receptor-regulated genes, ARRG). (hindawi.com)
  • Lota, Rupinder K. , Olusanjo, Moniola S. , Dhanani, Sachin , Owen, Caroline P. and Ahmed, Sabbir (2008) Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17[beta]-hydroxysteroid dehydrogenase (17[beta]-HSD3). (kingston.ac.uk)
  • Saw palmetto extract has been demonstrated to inhibit both isoforms of 5-alpha-reductase unlike finesteride which only inhibits the (predominant) type 2 isoenzyme of 5-alpha-reductase. (bulkpharma.net)
  • Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking. (ox.ac.uk)
  • The human type 10 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD-10) is a multifunctional mitochondrial enzyme that efficiently catalyzes the oxidative inactivation at C17 of androgens and estrogens. (ox.ac.uk)
  • Are tissue specific FXR agonists preferable for different indications, or might one type of ligand fit all purposes? (kenzpub.com)
  • STAT6-deficient GBM cells showed a reduction in 3 H-Thymidine uptake compared to the wild-type. (beds.ac.uk)
  • A project of permanent information through the introduction of a nursing portfolio on a specific subject Aberrant DNA methylation of E-cadherin and p16 genes in rat generic cialis availability date lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. (fillgun.info)
  • KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis showed that 1-acyl-sn-glycerol-3-phosphate acyltransferase ( LPAAT ), phospholipase D, acetyl-CoA carboxylase carboxyltransferase beta subunit, 3-hydroxyisobutyryl-CoA hydrolase-like and pyruvate dehydrogenase E1 β subunit were associated with fatty acid biosynthesis or metabolism. (biomedcentral.com)
  • The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH. (bvsalud.org)
  • 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (AKR1C1), mRNA. (abnova.com)
  • Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. (wikipathways.org)
  • Features being engineered into these enzymes include (1) self-assembly into hydrogels, (2) alternate cofactor use, and (3) broader substrate specificity. (proteopedia.org)
  • 3. The system of claim 1 wherein the diaphorase catalyzes the reduction of the competing substrate and the chromogen with similar efficiency. (freepatentsonline.com)
  • 4. The system of claim 3 wherein said competing substrate causes the amount of color generated by said chromogen to be linearly related to the concentration of the NAD(P)H. (freepatentsonline.com)
  • This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. (creativebiomart.net)
  • The rat central nervous system (CNS) has previously been shown to synthesize pregnenolone (PREG) and convert it to progesterone (PROG) and 7 alpha-hydroxy-PREG (7 alpha-OH PREG). (rupress.org)
  • 11α-Hydroxyprogesterone (11α-OHP), or 11α-hydroxypregn-4-ene-3,20-dione is an endogenous steroid and metabolite of progesterone. (wikipedia.org)
  • To study the effects of WCF extract on the activities of ovarian 3 [3-hydroxy steroid dehydrogenase [3beta-HSD] responsible for the synthesis of progesterone and 20 alpha-HSD responsible for its degradation in rats . (bvsalud.org)
  • The extract of WCF decreased the ovarian 3beta-HSD specific activity by 47%, serum progesterone concentration by 30% and the number of live embryos by 67%, but it had no effect on the specific activity of ovarian 20alpha-HSD. (bvsalud.org)
  • 1986. Microsonal $20{\alpha}$ -atiol and $20{\alpha}$ -hydroxysteroid dehydrogenase activity for progesterone in human placenta. (koreascience.or.kr)
  • 1970. The roles of pregn- 5-ene- $3{\beta}$ , $20{\alpha}$ -atiol and $20{\alpha}$ -hydroxysteroid dehydro-genase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. (koreascience.or.kr)
  • In vivo, the expression of 20 alpha SDH is thymus dependent, in that splenic lymphocytes from athymic mice have only low levels of activity, although the levels of enzyme activity increase gradually with age. (jimmunol.org)
  • Also has some 20-alpha-hydroxysteroid dehydrogenase activity. (hmdb.ca)
  • No studies have been performed up to now, in order to evaluate the possible presence of the 5 alpha-reductase activity in peripheral myelinated nerves. (unimi.it)
  • To this purpose the 5 alpha-reductase activity has been evaluated in the sciatic nerve of the rat and compared to that present in the cerebral cortex and in the subcortical white matter, a central structure mainly composed of myelinated fibers. (unimi.it)
  • No age-related variations in the 5 alpha-reductase activity in the cerebral cortex and in the subcortical white matter have been observed. (unimi.it)
  • It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. (bvsalud.org)
  • To determine if detected activity of signaling pathways that interact with AR pathway activity (e.g., phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [PI3K] and downstream effectors, SRC proto-oncogene, non-receptor tyrosine kinase [SRC], others) correlate with detected AR activity, PFS, and OS. (clinicaltrials.gov)
  • This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. (creativebiomart.net)
  • 4 3-ketosteroid-isomerase (3 beta-HSD) activity], and converted to 7 alpha-OH PREG and 7 alpha-OH DHEA, respectively (7 alpha-hydroxylase activity). (rupress.org)
  • The results expressed per cell indicated that the 3 beta-HSD activity was almost completely inhibited at high cell density, in contrast to the 7 alpha-hydroxylation which was maintained or increased. (rupress.org)
  • The pattern of steroid metabolism was related to cell density at the time of measurement and not to an early commitment of cells: when primary cultures were plated at high density (8 x 10(6) cells/dish), then subcultured after several dilutions (3-, 9-, or 27-fold), the 3 beta-HSD activity was recovered only at low density. (rupress.org)
  • Furthermore, when 5 x 10(5) cells were centrifuged and the resulting clusters were plated, 3 beta-HSD activity was decreased, whereas steroid 7 alpha-hydroxylation was enhanced. (rupress.org)
  • 3 beta-hydroxysteroid dehydrogenase activity in tissues of the human fetus determined with 5 alpha-androstane-3 beta,17 beta-diol and dehydroepiandrosterone as substrates. (fillgun.info)
  • The increasing awareness and concern about the potential health risks posed to the ecosystem and to man by endocrine disrupting chemicals with oestrogen-like activity in the environment has focused attention on the need for developing sensitive and specific methods for identifying these xenobiotics and to evaluate their degrees of toxic effects. (bvsalud.org)
  • Thus, mutation of Thr12 to Ala results in a complete loss of the 3 beta-dehydrogenase activity, whereas the 3-oxoreductase activity remains unchanged. (ox.ac.uk)
  • Experiments with isoform-specific AKR1C inhibitors in preadipocytes showed that AKR1C2 inhibition significantly decreased 3alpha-HSD and 3beta-HSD activities (3alpha-HSD: 30 +/- 24% of control for s.c. and 32 +/- 9% of control for Om, 3beta-HSD: 44 +/- 12% of control for s.c. (nih.gov)
  • We report the synthesis and biochemical evaluation of a number of 4-hydroxyphenyl ketones as potential inhibitors of the enzyme 17beta-hydroxysteroid dehydrogenase (17beta-HSD). (kingston.ac.uk)
  • Unlike most known 5-alpha-reductase inhibitors, saw palmetto induces its effects without interfering with the cellular capacity to secrete PSA. (bulkpharma.net)
  • This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism. (wikipedia.org)
  • However, it also mediates oxidation of 3 alpha-hydroxy groups of androgens, thereby reactivating androgen metabolites. (ox.ac.uk)
  • 1994. Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). (koreascience.or.kr)
  • Finally, it is involved in beta-oxidation of fatty acids by catalyzing the L-hydroxyacyl CoA dehydrogenase reaction of the beta-oxidation cycle. (ox.ac.uk)
  • Our interpretation of the available crystal structure of 3 alpha/20 beta-HSD from Streptomyces hydrogenans suggests a hydrogen bond in that enzyme between the Thr12 side chain and the backbone NH of Asn87 rather than the coenzyme, indicating that this hydrogen bond to the beta D strand might determine a crucial difference between the reductive and the oxidative reaction types. (ox.ac.uk)
  • The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (uniprot.org)
  • Various antidepressants, including the SSRIs fluoxetine, fluvoxamine, sertraline, and paroxetine, the SNRI venlafaxine, and mirtazapine, have been found to activate certain 3α-HSD enzymes, resulting in a selective facilitation of 5α-dihydroprogesterone conversion into allopregnanolone. (wikipedia.org)
  • AdhD alcohol dehydrogenase from the thermophile Pyrococcus furiosus is one of the enzymes being engineered with these features by the Banta Lab. (proteopedia.org)
  • along with Drosophia alcohol dehydrogenase (S00319 in EzCatDB). (cbrc.jp)
  • 1989. Purification and characterization of pig adrenal $20{\alpha}$ -hydroxysteroid dehydro-genage. (koreascience.or.kr)
  • Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine. (jimmunol.org)
  • In 1995, 11α-OHP, along with its epimer 11β-hydroxyprogesterone, was identified as a very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). (wikipedia.org)
  • 1979. Purification of $20{\alpha}$ - hydroxysteroid dehydro-genase by affinity chromatography. (koreascience.or.kr)
  • The study in aged rats has shown that in the sciatic nerve, the formation of DHT and particularly that of 3 alpha-diol are much lower than in younger animals. (unimi.it)
  • Couples can have this expensive screening which finds isolates the specific mutations of up to 1400 genetic conditions. (cypruscrownivf.com)
  • It is known to be necessary for the synthesis of the endogenous neurosteroids allopregnanolone, THDOC, and 3α-androstanediol. (wikipedia.org)
  • The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. (princeton.edu)
  • 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta 5 -ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. (uniprot.org)
  • At present, 11 different mammalian 17 beta-hydroxysteroid dehydrogenases have been identified, catalyzing the cell- and steroid-specific activation and inactivation of estrogens and androgens. (ox.ac.uk)
  • siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference. (abnova.com)
  • 1992. Changes of two kinds of $20{\alpha}$ - hydroxysteroid dehydrogenase during luteal phase in the rat. (koreascience.or.kr)
  • Triose phosphate isomerase, cellulose synthase and glucan 1,3-β-glucosidase were related to carbohydrate metabolism, and phosphoenolpyruvate carboxylase was related to both fatty acid and carbohydrate metabolism. (biomedcentral.com)
  • DHT plays an important role in several human diseases, which include acne, hirsutism, male pattern baldness, benign prostate hyperplasia (BPH), and prostate cancer (CaP) [ 3 ]. (hindawi.com)
  • There was some variation among the different shRNA- silenced clones, but all had a reduction in 3 H-Thymidine uptake ranging from 35%- 70% in U-1242MG and 40- 50% in U-87MG cells. (beds.ac.uk)
  • Similarly, mutation of Asn87 to Ala results in an 80% reduction of kcat/Km in the dehydrogenase direction but also unchanged 3-oxoreductase properties. (ox.ac.uk)
  • 1990. Participation of ovarian $20{\alpha}$ -hydroxysteroid dehydrogenase in luteotrophic and luteolytic processes during rat pseudopregnancy. (koreascience.or.kr)
  • This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. (wikipedia.org)
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. (abcam.com)
  • The first step is to determine which of the 3 general categories of DSD the patient belongs in. (clinicaladvisor.com)
  • HSD in the placental tissues seems to be related the number of fetal survived in the specific time (days 11 and 12) which spontaneous fetal loss occurs. (koreascience.or.kr)
  • 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. (abcam.com)