Colonic Neoplasms: Tumors or cancer of the COLON.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Colon, Sigmoid: A segment of the COLON between the RECTUM and the descending colon.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Sigmoid Neoplasms: Tumors or cancer of the SIGMOID COLON.Sigmoid Diseases: Pathological processes in the SIGMOID COLON region of the large intestine (INTESTINE, LARGE).Cecum: The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.Adenoma: A benign epithelial tumor with a glandular organization.11-beta-Hydroxysteroid Dehydrogenases: Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.11-beta-Hydroxysteroid Dehydrogenase Type 1: A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.11-beta-Hydroxysteroid Dehydrogenase Type 2: An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.Hydroxysteroid Dehydrogenases: Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.17-Hydroxysteroid Dehydrogenases: A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Progesterone Reductase: An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of NAD. It converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. EC 220.127.116.11.Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.Cortisone Reductase: An enzyme that catalyzes the interconversion of a ketone and hydroxy group at C-20 of cortisone and other 17,20,21-trihydroxy steroids. EC 18.104.22.168.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.20-Hydroxysteroid Dehydrogenases: A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 22.214.171.124) or to a 20-beta-hydroxysteroid (EC 126.96.36.199).Hydroxyprostaglandin Dehydrogenases: Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Aldehyde Reductase: An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 188.8.131.52.Mice, Inbred AKRSearch Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.AKR murine leukemia virus: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from spontaneous leukemia in AKR strain mice.Glycyrrhetinic Acid: An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.17-alpha-Hydroxyprogesterone: A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.Hydroxyprogesterones: Metabolites or derivatives of PROGESTERONE with hydroxyl group substitution at various sites.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Carbenoxolone: An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.Glycyrrhizic Acid: A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.Glycyrrhiza: A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.17-alpha-Hydroxypregnenolone: A 21-carbon steroid that is converted from PREGNENOLONE by STEROID 17-ALPHA-HYDROXYLASE. It is an intermediate in the delta-5 pathway of biosynthesis of GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.Bile Acids and Salts: Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.Metabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Bile: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.Enterohepatic Circulation: Recycling through liver by excretion in bile, reabsorption from intestines (INTESTINAL REABSORPTION) into portal circulation, passage back into liver, and re-excretion in bile.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Cholic Acids: The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.Bile Ducts: The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.Cholic Acid: A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.Adrenal Cortex: The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Pregnancy Trimester, Second: The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Glucose Clamp Technique: Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Adipocytes: Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Adipose Tissue: Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.Comamonas testosteroni: A species of gram-negative, aerobic rods formerly called Pseudomonas testosteroni. It is differentiated from other Comamonas species by its ability to assimilate testosterone and to utilize phenylacetate or maleate as carbon sources.Comamonas: A genus of gram-negative, straight or slightly curved rods which are motile by polar flagella and which accumulate poly-beta-hydroxybutyrate within the cells.Cocos: A plant genus of the family ARECACEAE. It is a tropical palm tree that yields a large, edible hard-shelled fruit from which oil and fiber are also obtained.Arecaceae: The palm family of order Arecales, subclass Arecidae, class Liliopsida.Nelumbo: A plant genus of the family NELUMBONACEAE. The common name of lotus is also for LOTUS and NYMPHAEA.Endosperm: Nutritive tissue of the seeds of flowering plants that surrounds the EMBRYOS. It is produced by a parallel process of fertilization in which a second male gamete from the pollen grain fuses with two female nuclei within the embryo sac. The endosperm varies in ploidy and contains reserves of starch, oils, and proteins, making it an important source of human nutrition.Polyporales: An order of fungi in the phylum BASIDIOMYCOTA having macroscopic basidiocarps. The members are characterized by their saprophytic activities as decomposers, particularly in the degradation of CELLULOSE and LIGNIN. A large number of species in the order have been used medicinally. (From Alexopoulos, Introductory Mycology, 4th ed, pp504-68)Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Plant Oils: Oils derived from plants or plant products.Tropical Climate: A climate which is typical of equatorial and tropical regions, i.e., one with continually high temperatures with considerable precipitation, at least during part of the year. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Poria: A genus of basiodiomycetous fungi in the family Coriolaceae. Members are known for infesting wood.Coriolaceae: A family of fungi, order POLYPORALES, found on decaying wood.
Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a ... Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11 ... Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to ... "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional ...
HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene". ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver". Pharmacogenetics. 9 (6): 763-71. doi:10.1097/00008571- ... "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells. 5 (2): ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...
3alpha-hydroxysteroid dehydrogenase (B-specific)
Marcus PI; Talalay P (1956). "Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases". J. Biol. Chem. 218 ... In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 184.108.40.206) is an enzyme that catalyzes the chemical ... B-specific). Other names in common use include hydroxyprostaglandin dehydrogenase, 3alpha-hydroxysteroid oxidoreductase, and ... more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha- ...
3alpha-hydroxysteroid dehydrogenase (A-specific)
In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 220.127.116.11) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific). As of late 2007, 11 ... Tomkins GM (1956). "A mammalian 3alpha-hydroxysteroid dehydrogenase". J. Biol. Chem. 218: 437-447. Molecular and Cellular ... more specifically it is part of the group of hydroxysteroid dehydrogenases. ...
May 2005). "Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo". J. Biol. Chem. 280 (19): 18822 ... Some retinol dehydrogenases are in extra-ocular tissues, such as human retinol dehydrogenase-4 (RoDH-4), which converts retinol ... One of the widely studied genes of retinol dehydrogenase RDH12, which encodes retinol dehydrogenase is part of the superfamily ... retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". ...
Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R (Aug 2003). "Human 20alpha-hydroxysteroid dehydrogenase: ... "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid ... O'connor T, Ireland LS, Harrison DJ, Hayes JD (Oct 1999). "Major differences exist in the function and tissue-specific ... Zhang Y, Dufort I, Rheault P, Luu-The V (Oct 2000). "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". Journal ...
Moghrabi N, Head JR, Andersson S (Nov 1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in ... variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen ... 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in ... a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity". The Journal of Biological Chemistry. 268 (17): ...
In accordance, 11α- and 11β-hydroxyprogesterone are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... However, formebolone was found to be a very weak inhibitor of 11β-HSD type 2, although this specific isoenzyme is responsible ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...
Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene. Dlx3 is a crucial regulator of hair follicle ... 7 (3): 563-9. doi:10.1093/hmg/7.3.563. PMID 9467018. Roberson MS, Meermann S, Morasso MI, et al. (2001). "A role for the ... 38 (3): 314-24. doi:10.1006/geno.1996.0634. PMID 8975708. Price JA, Bowden DW, Wright JT, et al. (1998). "Identification of a ... 145 (3): 1096-105. doi:10.1210/en.2003-0777. PMID 14670999. Haldeman RJ, Cooper LF, Hart TC, et al. (2005). "Increased bone ...
"Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities". Life Sciences. 68 (7): 751-61 ... The gene has nine coding exons and a number of alternative non-coding first exons that regulate tissue specific expression. ... Om AS, Chung KW (April 1996). "Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen ... Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn ...
... factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase ... is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes". The Journal of Biological Chemistry ... "Entrez Gene: TEAD3 TEA domain family member 3". Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding ...
20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor". Structure. 2 (10): 973-80. doi:10.1016/S0969- ... has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains. ... Glucose/ribitol dehydrogenase InterPro: IPR002347 Insect alcohol dehydrogenase family InterPro: IPR002424 2,3-dihydro-2,3- ... alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases ...
Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of ... although this specific isoenzyme of 11β-HSD is responsible for the inactivation of glucocorticoids rather than their production ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...
... which regulates the expression of the enzyme 17β-hydroxysteroid dehydrogenase that is used to convert androstenedione, the ... Dunson, D.B.; Baird, D.D.; Wilcox, A.J.; Weinberg, C.R. (1999). "Day-specific probabilities of clinical pregnancy based on two ... In contrast to the alpha gene activity, beta LH subunit gene activity is restricted to the pituitary gonadotropic cells. It is ... LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is responsible for the specificity ...
The gene has these neighbors on chromosome 9: HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide ... Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific ... According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal ... KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth ...
... specifically with local expression at the skin of reductive 17β-hydroxysteroid dehydrogenase, and oxidative 3α-hydroxysteroid ... 2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases". Adv Urol. 2012: ... Specific substrates include testosterone, progesterone, androstenedione, epitestosterone, cortisol, aldosterone, and ... "FDA Alert: 5-alpha reductase inhibitors (5-ARIs): Label Change - Increased Risk of Prostate Cancer". Drugs.com. Retrieved 2014- ...
"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine Reviews. 25 (5 ... It inhibits production of interleukin (IL)-12, interferon (IFN)-gamma, IFN-alpha, and tumor-necrosis-factor (TNF)-alpha by ... Cortisol is also metabolized into 5-alpha tetrahydrocortisol (5-alpha THF) and 5-beta tetrahydrocortisol (5-beta THF), ... Cortisol is metabolized by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: 11- ...
The conversion of androstenedione to testosterone is catalyzed by 17β-hydroxysteroid dehydrogenase (17β-HSD), whereas the ... The estrogen:ER complex binds to specific DNA sequences called a hormone response element to activate the transcription of ... "Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells". Genome Biology. 5 (9): R66. doi ... estradiol is dehydrogenated by 17β-Hydroxysteroid dehydrogenase into the much less potent estrogen estrone. These reactions ...
Her team was the first to publish mutations on the 11β-hydroxysteroid dehydrogenase type 2 enzyme (encoded by the HSD11B2 gene ... President's Council of Cornell Women Alpha Omega Alpha, University of Pennsylvania School of Medicine New York Practitioner's ... New was first to identify the mild form with specific molecular mutations. Dr. Maria Iandolo New married Dr. Bertrand Latimer ... to study specific steroid hormone production during infancy, childhood and adolescence. In 1964, Dr. New was ...
11-β-hydroxysteroid dehydrogenase type 2 and corticotrophin releasing hormone. Epigenetic modification of these genes may lead ... pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha ... A highly specific diet, termed an "EpiG diet," may be employed for an individual believed to be at higher risk of developing a ... While epigenetic modifications are most likely involved in the development of obesity, the specific target genes have yet to be ...
List of MeSH codes (D08)
3alpha-hydroxysteroid dehydrogenase (B-specific) MeSH D08.811.682.047.436.350.150 --- cholesterol oxidase MeSH D08.811.682.047. ... succinate dehydrogenase MeSH D08.811.682.660.900 --- testosterone 5-alpha-Reductase MeSH D08.811.682.662.162 --- ... 11-beta-hydroxysteroid dehydrogenase type 1 MeSH D08.811.682.047.436.174.600 --- 11-beta-hydroxysteroid dehydrogenase type 2 ... hydroxysteroid dehydrogenases MeSH D08.811.682.047.436.174 --- 11-beta-hydroxysteroid dehydrogenases MeSH D08.811.682.047. ...
Hsd3b2 - 3 beta-hydroxysteroid dehydrogenase/Delta 5--|4-isomerase type 2 - Mus musculus (Mouse) - Hsd3b2 gene & protein
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the ... The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. ... Organism-specific databases. Mouse genome database (MGD) from Mouse Genome Informatics (MGI) ... It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel ...http://www.uniprot.org/uniprot/P26149
Coexpression cluster:C125 - resource browser
A-specific) activity. 0.000196426050335292. GO:0047115. trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity. ... testosterone 17-beta-dehydrogenase (NADP+) activity. 0.0395363767192471. GO:0047756. chondroitin 4-sulfotransferase activity. ... testosterone 17-beta-dehydrogenase activity. 0.046617552219066. GO:0030971. receptor tyrosine kinase binding. 0.046617552219066 ...http://fantom.gsc.riken.jp/5/sstar/Coexpression_cluster:C125
AKR1C3 - Wikipedia
Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a ... Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11 ... Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to ... "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional ...https://en.wikipedia.org/wiki/AKR1C3
3α-Hydroxysteroid dehydrogenase - Wikipedia
HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene". ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver". Pharmacogenetics. 9 (6): 763-71. doi:10.1097/00008571- ... "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells. 5 (2): ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...https://en.wikipedia.org/wiki/3%CE%B1-Hydroxysteroid_dehydrogenase
Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men. - PubMed - NCBI
... alpha--,beta)-hydroxysteroid epimerase were significantly higher in Om fat. 3Alpha/beta-HSD activity was mainly detected in the ... Experiments with isoform-specific AKR1C inhibitors in preadipocytes showed that AKR1C2 inhibition significantly decreased ... hydroxysteroid dehydrogenase type 2) and 3( ... 2006 Dec;191(3):637-49. Research Support, Non-U.S. Gov't ... J Endocrinol. 2006 Dec;191(3):637-49.. Androgen inactivation and steroid-converting enzyme expression in abdominal adipose ...https://www.ncbi.nlm.nih.gov/pubmed/17170221
RCSB PDB - 1AFS: RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND...
... crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. ... Androsterone Dehydrogenase Activity * Androsterone Dehydrogenase (b Specific) Activity * Steroid Metabolic Process * ... Alpha Beta Alpha-Beta Barrel TIM Barrel NADP-dependent oxidoreductase B. 1afsB00. Alpha Beta Alpha-Beta Barrel TIM Barrel NADP- ... Alpha and beta proteins (a/b) TIM beta/alpha-barrel NAD(P)-linked oxidoreductase Aldo-keto reductases (NADP) 3-alpha- ...http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1AFS
RCSB PDB - 1FJH: THE CRYSTAL STRUCTURE OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER...
... reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase ... Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Tyrosine-dependent ... Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Tyrosine-dependent ... Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain ...http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1FJH
3alpha-hydroxysteroid dehydrogenase (B-specific). (EC 18.104.22.168). hydroxyprostaglandin dehydrogenase. (EC 22.214.171.124). 3alpha- ... Androsterone + NAD(P)(+) = 5-alpha-androstane-3,17-dione + NAD(P)H. ... 3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: biological significance, three-dimensional ... The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel ...http://ezcatdb.cbrc.jp/EzCatDB/search/get.do?dbcode=S00325
'Junk' DNA: Why non-coding DNA Isn't Really...
Genes are pieces of DNA, and most genes contain the information for making a specific protein.gene (26), the alpha-globin The ... alcohol dehydrogenase (32), 3 alpha-hydroxysteroid dehydrogenases (33), apolipoprotein A-II (34), beta1,4-N- ... Genes are pieces of DNA, and most genes contain the information for making a specific protein.gene (36), Alpha-1 acid ... Properties of the mouse alpha-globin HS-26: relationship to HS-40, the major enhancer of human alpha-globin The functional and ...http://www.godandscience.org/evolution/junkdna.html
Human Metabolome Database: Showing metabocard for 7 alpha-Hydroxy-3-oxo-4-cholestenoate (HMDB0012458)
Specific function:. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal ... 7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity. Gene Name:. CYP27A1. Uniprot ID:. Q02318 Molecular ... 7 alpha-Dihydroxy-5-cholestenoate or 7 alpha,26-Dihydroxy-4-cholesten-3-one through the actions of HSD3B7 (EC:126.96.36.199) or ... 7 alpha-Dihydroxy-5-cholestenoate + NAD → 7 alpha-Hydroxy-3-oxo-4-cholestenoate + NADH + Hydrogen Ion. details. ...http://www.hmdb.ca/metabolites/HMDB12458
Human Metabolome Database: Showing metabocard for 7 alpha,26-Dihydroxy-4-cholesten-3-one (HMDB0012459)
Specific function:. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal ... 26-hydroxysteroid. *Dihydroxy bile acid, alcohol, or derivatives. *3-oxo-delta-4-steroid ... 7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity. Gene Name:. CYP27A1. Uniprot ID:. Q02318 Molecular ... 7 alpha,26-Dihydroxy-4-cholesten-3-one. Description. 7 alpha,26-Dihydroxy-4-cholesten-3-one is involved in primary bile acid ...http://www.hmdb.ca/metabolites/HMDB0012459
Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from...
The enzyme 20 alpha-hydroxysteroid dehydrogenase (20 alpha SDH) has previously been shown to be a specific enzyme marker of ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ... Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from ...https://www.jimmunol.org/content/126/6/2184
Intersex Variations, Human Rights, and the International Classification of Diseases - Health and Human Rights Journal
World Health Organization, "46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency," in ICD ... Specific ICD codes Individual codes in the ICD-11-MMS and ICD-11 Foundation typically contain both a title and description. In ... World Health Organization, "46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency", in ICD-11 Foundation, ... and 17-beta-hydroxysteroid dehydrogenase 3 deficiency (17ß-HSD3) are notable. Each of these variations are associated with ...https://www.hhrjournal.org/2018/08/intersex-variations-human-rights-and-the-international-classification-of-diseases/
BRENDA - 188.8.131.52: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha- ... 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido- ... hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)- ... 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, ...http://www.brenda-enzymes.org/all_enzymes.php?ecno=184.108.40.206&table=Storage_Stability
BRENDA - 220.127.116.11: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
3alpha-hydroxy steroid, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3alpha- ... 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido- ... hydroxyprostaglandin dehydrogenase, More, NAD(P)+-3alpha-hydroxysteroid dehydrogenase, NAD+-dependent 3alpha-HSD, NADP(H)- ... 3alpha/3beta-hydroxysteroid dehydrogenase, 3alphaHSD, 3HSD, 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase, ...http://www.brenda-enzymes.org/all_enzymes.php?ecno=18.104.22.168&table=pH_Stability
anti-AKR1C3 antibody [C2C3], C-term | GeneTex
3-alpha hydroxysteroid dehydrogenase, type II)) for ICC/IF, IHC-P, IP, WB. Anti-AKR1C3 pAb (GTX104627) is tested in Human, Rat ... 2-diol dehydrogenase antibody, testosterone 17-beta-dehydrogenase 5 antibody, indanol dehydrogenase antibody, aldo-keto ... 1 mg/ml (Please refer to the vial label for the specific concentration). ... dihydrodiol dehydrogenase X antibody, chlordecone reductase homolog HAKRb antibody, 3-alpha-HSD type II, brain antibody, ...http://www.genetex.com/AKR1C3-antibody-C2C3-C-term-GTX104627.html
Recombinant human HSD3a protein (ab109831) | Abcam
Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to ... Specific activity is , 700 pmol/min/μg, and is defined as the amount of enzyme that catalyzes the reduction of 1.0 pmole 3- ... Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3- ...https://www.abcam.com/recombinant-human-hsd3a-protein-ab109831.html
The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester | SpringerLink
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. J Clin Endocrinol Metab ... Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3 beta-hydroxysteroid dehydrogenase/ ... Localization of cytochrome P450 cholesterol side-chain cleavage, cytochrome P450 17 alpha-hydroxylase/17, 20-lyase, and 3 beta- ... hydroxysteroid dehydrogenase isomerase steroidogenic enzymes in human and rhesus monkey fetal adrenal glands: reappraisal of ...https://link.springer.com/article/10.1186/s12916-018-1009-7
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole - Full Text View -...
... hydroxysteroid [17-beta] dehydrogenase [HSD17B]3, HSD17B6, AKR1C2, AKR1C1, UGTB15, UGTB17, steroid-5-alpha-reductase, alpha ... 14-alpha Demethylase Inhibitors. Cytochrome P-450 Enzyme Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological ... To determine if specific AR splice variations correlate with PFS in response to ketoconazole. ... To determine the presence of specific prostate cancer-associated gene translocations in each sample of CRPC. ...https://clinicaltrials.gov/ct2/show/NCT01275651?cond=%22Kennedy+disease%22&rank=60
IMP: Integrative Multi-species Prediction
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase). 0.844. ... SMAD specific E3 ubiquitin protein ligase 2. 0.987. Yeast AKR1C2. aldo-keto reductase family 1, member C2 (dihydrodiol ... dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III). 0.958. ... The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or ...http://imp.princeton.edu/predictions/process/human-context-global/4473/?gene=15690
- Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene. (wikipedia.org)
- 3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene. (wikipedia.org)
- and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. (cbrc.jp)
- A novel member of the short-chain dehydrogenase/reductase superfamily. (cbrc.jp)
- The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family. (cbrc.jp)
- A model on the regulation of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase expression in Comamonas testosteroni. (cbrc.jp)
- Tyr155 and Lys159 in 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. (cbrc.jp)
- Unlike most known 5-alpha-reductase inhibitors, saw palmetto induces its effects without interfering with the cellular capacity to secrete PSA. (bulkpharma.net)
- Saw palmetto extract has been demonstrated to inhibit both isoforms of 5-alpha-reductase unlike finesteride which only inhibits the (predominant) type 2 isoenzyme of 5-alpha-reductase. (bulkpharma.net)
- Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not appreciated until the discovery of 5 alpha-reductase type 2 deficiency in 1974. (hindawi.com)
- Several compounds have been developed to inhibit the 5 alpha-reductase isozymes and they play an important role in the prevention and treatment of many common diseases. (hindawi.com)
- This review describes the basic biochemical properties, functions, tissue distribution, chromosomal location, and clinical significance of the 5 alpha-reductase isozyme family. (hindawi.com)
- Intracellular T is converted to dihydrotestosterone (DHT), the preferred ligand for androgen receptor (AR) transactivation, by the enzyme 5 alpha-reductase (5 α -R). Upon ligand binding and transactivation, the DHT-AR complex translocates from cytoplasm to nucleus and activates the transcription of certain genes (the androgen receptor-regulated genes, ARRG). (hindawi.com)
- 7 alpha-Hydroxy-3-oxo-4-cholestenoate is involved in the primary bile acid biosynthesis pathway. (hmdb.ca)
- 7 alpha,26-Dihydroxy-4-cholesten-3-one is involved in primary bile acid biosynthesis. (hmdb.ca)
- This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. (creativebiomart.net)
- Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking. (ox.ac.uk)
- DHT plays an important role in several human diseases, which include acne, hirsutism, male pattern baldness, benign prostate hyperplasia (BPH), and prostate cancer (CaP) [ 3 ]. (hindawi.com)
- 3 beta-hydroxysteroid dehydrogenase activity in tissues of the human fetus determined with 5 alpha-androstane-3 beta,17 beta-diol and dehydroepiandrosterone as substrates. (fillgun.info)
- Various antidepressants, including the SSRIs fluoxetine, fluvoxamine, sertraline, and paroxetine, the SNRI venlafaxine, and mirtazapine, have been found to activate certain 3α-HSD enzymes, resulting in a selective facilitation of 5α-dihydroprogesterone conversion into allopregnanolone. (wikipedia.org)
- 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. (abcam.com)