3 alpha hydroxysteroid dehydrogenase b specific. Medical search

Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.

Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.

A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.

A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53).

A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.

Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.

A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the CAROTID BODY; GLOMUS JUGULARE; GLOMUS TYMPANICUM; AORTIC BODIES; and the female genital tract. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. (From Stedman, 27th ed)

A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.

Alcohol oxidoreductases with substrate specificity for LACTIC ACID.

Enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of NAD+ or NADP+ to yield estrone and NADH or NADPH. The 17-hydroxyl group can be in the alpha- or beta-configuration. EC 1.1.1.62

A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.

Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. EC 2.8.2.

A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).

A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

The rate dynamics in chemical or physical systems.

A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.

A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.

Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.

An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha-hydroxysteroids, such as from PROGESTERONE to 20-ALPHA-DIHYDROPROGESTERONE.

An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.

An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.

An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.

3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.

A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.

Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.

Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)

A flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield dihydrolipoamide and NAD+. The enzyme is a component of several MULTIENZYME COMPLEXES.

Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.

An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of NAD. It also acts on D-glucitol to form D-fructose. It also acts on other closely related sugar alcohols to form the corresponding sugar. EC 1.1.1.14

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

A glucose dehydrogenase that catalyzes the oxidation of beta-D-glucose to form D-glucono-1,5-lactone, using NAD as well as NADP as a coenzyme.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Oxidoreductases that are specific for ALDEHYDES.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.47; EC 1.1.1.118; EC 1.1.1.119 and EC 1.1.99.10.

An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.

Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.

Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS.

A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.

An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.

A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. It forms a complex with ELECTRON TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE.

Flavoproteins that catalyze reversibly the reduction of carbon dioxide to formate. Many compounds can act as acceptors, but the only physiologically active acceptor is NAD. The enzymes are active in the fermentation of sugars and other compounds to carbon dioxide and are the key enzymes in obtaining energy when bacteria are grown on formate as the main carbon source. They have been purified from bovine blood. EC 1.2.1.2.

An enzyme that catalyzes the oxidation of XANTHINE in the presence of NAD+ to form URIC ACID and NADH. It acts also on a variety of other purines and aldehydes.

Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.

A ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO2. The enzyme requires THIAMINE DIPHOSPHATE as a cofactor. Defects in genes that code for subunits of the enzyme are a cause of MAPLE SYRUP URINE DISEASE. The enzyme was formerly classified as EC 1.2.4.3.

Proteins prepared by recombinant DNA technology.

Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis.

The E1 component of the multienzyme PYRUVATE DEHYDROGENASE COMPLEX. It is composed of 2 alpha subunits (pyruvate dehydrogenase E1 alpha subunit) and 2 beta subunits (pyruvate dehydrogenase E1 beta subunit).

Oxidoreductases that are specific for KETONES.

The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

Inorganic salts of sulfuric acid.

An oxidoreductase involved in pyrimidine base degradation. It catalyzes the catabolism of THYMINE; URACIL and the chemotherapeutic drug, 5-FLUOROURACIL.

An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC 1.1.1.22.

Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.

A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.

A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).

One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a ... Khanna M, Qin KN, Wang RW, Cheng KC (Aug 1995). "Substrate specificity, gene structure, and tissue-specific distribution of ... Rheault P, Dufort I, Soucy P, Luu-The V (1999). "Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to ... "Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional ...

https://en.wikipedia.org/wiki/AKR1C3

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical ... The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific). As of late 2007, 11 ... Tomkins GM (1956). "A mammalian 3alpha-hydroxysteroid dehydrogenase". J. Biol. Chem. 218 (1): 437-447. PMID 13278351. Portal: ... more specifically it is part of the group of hydroxysteroid dehydrogenases. ...

https://en.wikipedia.org/wiki/3alpha-hydroxysteroid_dehydrogenase_(A-specific)

Marcus PI; Talalay P (1956). "Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases". J. Biol. Chem. 218 ... In enzymology, a 3alpha-hydroxysteroid dehydrogenase (B-specific) (EC 1.1.1.50) is an enzyme that catalyzes the chemical ... B-specific). Other names in common use include hydroxyprostaglandin dehydrogenase, 3alpha-hydroxysteroid oxidoreductase, and ... more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha- ...

https://en.wikipedia.org/wiki/3alpha-hydroxysteroid_dehydrogenase_(B-specific)

HNF-1 alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene". ... of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver". Pharmacogenetics. 9 (6): 763-71. doi:10.1097/00008571- ... "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes". Genes to Cells. 5 (2): ... "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference ...

https://en.wikipedia.org/wiki/3α-Hydroxysteroid_dehydrogenase

May 2005). "Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo". J. Biol. Chem. 280 (19): 18822 ... Some retinol dehydrogenases are in extra-ocular tissues, such as human retinol dehydrogenase-4 (RoDH-4), which converts retinol ... One of the widely studied genes of retinol dehydrogenase RDH12, which encodes retinol dehydrogenase is part of the superfamily ... retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". ...

https://en.wikipedia.org/wiki/Retinol_dehydrogenase

Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R (Aug 2003). "Human 20alpha-hydroxysteroid dehydrogenase: ... "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid ... O'connor T, Ireland LS, Harrison DJ, Hayes JD (Oct 1999). "Major differences exist in the function and tissue-specific ... Zhang Y, Dufort I, Rheault P, Luu-The V (Oct 2000). "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". Journal ...

https://en.wikipedia.org/wiki/AKR1C1

"11β-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response". Endocrine Reviews. 25 (5): ... 11 alpha-Hydroxyprogesterone (11 alpha OH-P) was an order of magnitude more potent a competitive inhibitor of the 11 beta HSD-2 ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of ...

https://en.wikipedia.org/wiki/11α-Hydroxyprogesterone

... in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J ... It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype ... that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3 (IL-3 ... The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM- ...

https://en.wikipedia.org/wiki/Interleukin_3

Moghrabi N, Head JR, Andersson S (Nov 1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in ... variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen ... 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in ... a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity". The Journal of Biological Chemistry. 268 (17): ...

https://en.wikipedia.org/wiki/HSD17B2

In accordance, 11α- and 11β-hydroxyprogesterone are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD ... Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... However, formebolone was found to be a very weak inhibitor of 11β-HSD type 2, although this specific isoenzyme is responsible ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...

https://en.wikipedia.org/wiki/Roxibolone

... formed by the 20α-hydroxysteroid dehydrogenases (20α-HSDs) AKR1C1, AKR1C2, and AKR1C3 and the 17β-hydroxysteroid dehydrogenase ... Nowak FV (April 2002). "Distribution and metabolism of 20 alpha-hydroxylated progestins in the female rat". J. Steroid Biochem ... 4-. ISBN 978-1-4200-7745-2. Marianne J. Legato (29 October 2009). Principles of Gender-Specific Medicine. Academic Press. pp. ... Casey ML, MacDonald PC, Andersson S (November 1994). "17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and ...

https://en.wikipedia.org/wiki/20α-Dihydroprogesterone

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene. Dlx3 is a crucial regulator of hair follicle ... 7 (3): 563-9. doi:10.1093/hmg/7.3.563. PMID 9467018. Roberson MS, Meermann S, Morasso MI, et al. (2001). "A role for the ... 38 (3): 314-24. doi:10.1006/geno.1996.0634. PMID 8975708. Price JA, Bowden DW, Wright JT, et al. (1998). "Identification of a ... 145 (3): 1096-105. doi:10.1210/en.2003-0777. PMID 14670999. Haldeman RJ, Cooper LF, Hart TC, et al. (2005). "Increased bone ...

https://en.wikipedia.org/wiki/DLX3

2005). "A novel somatic mutation of the 3beta-hydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma". ... Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating is an enzyme that in humans is encoded by the NSDHL gene. This ... Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788-95 ... encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome". Am J Med Genet. 90 (4): 339-46. doi:10.1002/(SICI)1096- ...

https://en.wikipedia.org/wiki/NSDHL

... factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase ... is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes". The Journal of Biological Chemistry ... "Entrez Gene: TEAD3 TEA domain family member 3". Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding ...

https://en.wikipedia.org/wiki/TEAD3

20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor". Structure. 2 (10): 973-80. doi:10.1016/S0969- ... has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains. ... Glucose/ribitol dehydrogenase InterPro: IPR002347 Insect alcohol dehydrogenase family InterPro: IPR002424 2,3-dihydro-2,3- ... alcohol dehydrogenases. Most members of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases ...

https://en.wikipedia.org/wiki/Short-chain_dehydrogenase

"Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities". Life Sciences. 68 (7): 751-61 ... The gene has nine coding exons and a number of alternative non-coding first exons that regulate tissue specific expression. ... Om AS, Chung KW (April 1996). "Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen ... Aromatase is localized in the endoplasmic reticulum where it is regulated by tissue-specific promoters that are in turn ...

https://en.wikipedia.org/wiki/Aromatase

Souness GW, Morris DJ (1996). "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid ... are known to be potent inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD), which is responsible for the biosynthesis of ... although this specific isoenzyme of 11β-HSD is responsible for the inactivation of glucocorticoids rather than their production ... potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on ...

https://en.wikipedia.org/wiki/Formebolone

The reductive pathways are by 11β-hydroxysteroid dehydrogenase type 1 in the liver and AKR7A2/AKR7A3 in the intestine leading ... The alpha position adjacent to the ketone is first brominated followed by nucleophilic displacement of the resulting alpha- ... "Antidepressants for non-specific low back pain". The Cochrane Database of Systematic Reviews (1): CD001703. doi:10.1002/ ... Based on studies indicating that bupropion lowers the level of the inflammatory mediator TNF-alpha, there have been suggestions ...

https://en.wikipedia.org/wiki/Bupropion

"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine Reviews. 25 (5 ... 5-alpha THF) and 5-beta tetrahydrocortisol (5-beta THF), reactions for which 5-alpha reductase and 5-beta-reductase are the ... "Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an ... and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specific". Chemico ...

https://en.wikipedia.org/wiki/Cortisol

... include autosomal recessive disorders with mutations lowering the activity of the enzyme 11-beta-hydroxysteroid dehydrogenase ... Deficiency of 17-alpha-hydroxylase blocks the conversion of pregnenolone and progesterone to their 17-a-hydroxy forms leading ... In some cases, specific antihypertensive medications may be recommended. In Liddle's syndrome, ENaC-binding potassium-sparing ... Specific treatment of pseudohyperaldosteronism depends on the inciting cause. General management focuses on countering the ...

https://en.wikipedia.org/wiki/Pseudohyperaldosteronism

The gene has these neighbors on chromosome 9: HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide ... Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific ... According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal ... KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth ...

https://en.wikipedia.org/wiki/KIAA1958

... specifically with local expression at the skin of reductive 17β-hydroxysteroid dehydrogenase, and oxidative 3α-hydroxysteroid ... 2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases". Adv. Urol. 2012: ... Specific substrates include testosterone, progesterone, androstenedione, epitestosterone, cortisol, aldosterone, and ... Wang J, Zhao S, Luo L, Li E, Li X, Zhao Z (2018). "5-alpha Reductase Inhibitors and risk of male breast cancer: a systematic ...

https://en.wikipedia.org/wiki/5α-Reductase_inhibitor

... and then finally converted to testosterone by 17β-hydroxysteroid dehydrogenase (HSD17B). The onset of puberty is controlled by ... labeled alpha- and beta- subunits) that are non-covalently associated: The alpha subunits of LH, FSH, TSH, and hCG are ... LH has a beta subunit of 120 amino acids (LHB) that confers its specific biologic action and is responsible for the specificity ... The gene for the alpha subunit is located on chromosome 6q12.21. The luteinizing hormone beta subunit gene is localized in the ...

https://en.wikipedia.org/wiki/Luteinizing_hormone

Her team was the first to publish mutations on the 11β-hydroxysteroid dehydrogenase type 2 enzyme (encoded by the HSD11B2 gene ... President's Council of Cornell Women Alpha Omega Alpha, University of Pennsylvania School of Medicine New York Practitioner's ... to study specific steroid hormone production during infancy, childhood and adolescence.[citation needed] In 1964, New was ... New was first to identify the mild form with specific molecular mutations. New has received numerous honors, including: IPSEN ...

https://en.wikipedia.org/wiki/Maria_New

Hepatic metabolism is mediated by 11 beta-hydroxysteroid dehydrogenases (11[beta]-HSD) and 20-ketosteroid reductases. ... A specific example is the deacetylation by histone deacetylase 2 (HDACe) was necessary for transrepression of NF-κB. The ... alpha]-hydroxymethylprednisolone. As stated previously, the primary use of methylprednisolone is to suppress inflammatory and ... Specific immune functions effected by this process are cytokinesis, migration, phagocytosis, antigen processing and presenting ...

https://en.wikipedia.org/wiki/Methylprednisolone

Estrone can also be converted by 17β-hydroxysteroid dehydrogenases into the more potent estrogen estradiol. E1S levels are much ... Instead, estrone sulfate is transported into cells in a tissue-specific manner by active transport via organic-anion- ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ... For this reason, enzyme inhibitors of steroid sulfatase and 17β-hydroxysteroid dehydrogenase and inhibitors of OATPs, which ...

https://en.wikipedia.org/wiki/Estrone_sulfate

20 lyase deficiency 17β-hydroxysteroid dehydrogenase deficiency 5α-reductase deficiency Androgen excess in 46,XX individuals: ... Taneja SS, Ha S, Swenson NK, Huang HY, Lee P, Melamed J, Shapiro E, Garabedian MJ, Logan SK (December 2005). "Cell-specific ... Testosterone is converted into dihydrotestosterone by the 5-alpha reductase enzyme. If this enzyme is absent or deficient, then ... When used to screen for a specific genetic sequence, its main advantage is that it avoids selective pregnancy termination, as ...

https://en.wikipedia.org/wiki/Androgen_insensitivity_syndrome

Aromatase and 17beta-hydroxysteroid dehydrogenase are aberrantly expressed in fibroids, indicating that fibroids can convert ... Specific mutations of the MED12 protein have been noted in 70 percent of fibroids. The exact cause of fibroids is not clearly ... and promotes survival through up-regulating Bcl-2 expression and down-regulating TNF-alpha. Progesterone is believed to ... Only a few specific genes or cytogenetic deviations are associated with fibroids. 80-85% of fibroids have a mutation in the ...

https://en.wikipedia.org/wiki/Uterine_fibroid

April 2007). "Impaired protein stability of 11beta-hydroxysteroid dehydrogenase type 2: a novel mechanism of apparent ... The specific mechanism involved is increased release of the "stress hormones", epinephrine (adrenaline) and norepinephrine ... 17 alpha-hydroxylase deficiency causes an inability to produce cortisol. Instead, extremely high levels of the precursor ... involves a defect in the gene for 11β-hydroxysteroid dehydrogenase, an enzyme that normally inactivates circulating cortisol to ...

https://en.wikipedia.org/wiki/Secondary_hypertension

Pollow K, Lübbert H, Pollow B (January 1976). "On the mitochondrial 17beta-hydroxysteroid dehydrogenase from human endometrium ... For the predicting location of alpha helices and beta sheets, Phyre 2 was used. For the alpha helices, there is a high-level ... These all play a specific role in cell cycle regulation. There is also a conceptual translation for C16orf86 below with the ... It is mostly made of alpha helices and it is expressed in the testes, but also in other tissues such as the kidney, colon, ...

https://en.wikipedia.org/wiki/C16orf86

... estrone is also formed reversibly from estradiol by the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD) in various tissues, ... It is a white, odorless, solid crystalline powder, with a melting point of 254.5 °C (490 °F) and a specific gravity of 1.23. ... "Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta". Biochemical ... 511-. ISBN 978-3-642-96158-8. E. A. Doisy and A. Butenandt reported almost at the same time on the isolation of an estrogen- ...

https://en.wikipedia.org/wiki/Estrone

... hydroxysteroid dehydrogenase type 3 enzyme deficiencies). The measurement of the serum DHT concentration is challenging since ... 5α-Reductase type 2 (5αR2) is an enzyme, encoded by the SRD5A2 gene, that is expressed in specific tissues in the male body ... OMIM article 5-Alpha-Reductase Deficiency at eMedicine (Articles with short description, Short description matches Wikidata, ... XY DSD from other causes such as partial androgen insensitivity syndrome and 17β-hydroxysteroid dehydrogenase 3 deficiency. ...

https://en.wikipedia.org/wiki/5α-Reductase_2_deficiency

RAG1 Alpha-2-plasmin inhibitor deficiency; 262850; PLI Alpha-ketoglutarate dehydrogenase deficiency; 203740; OGDH Alpha- ... CYP17A1 17-beta-hydroxysteroid dehydrogenase X deficiency; 300438; HSD17B10 2-methylbutyrylglycinuria; 610006; ACADSB 3- ... KIAA0196 Specific granule deficiency; 245480; CEBPE Speech-language disorder-1; 602081; FOXP2 Spherocytosis, hereditary, type 5 ... PC Pyruvate dehydrogenase deficiency; 312170; PDHA1 Pyruvate dehydrogenase E2 deficiency; 245348; DLAT Pyruvate dehydrogenase ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

Rosler A (August 2006). "17 beta-hydroxysteroid dehydrogenase 3 deficiency in the Mediterranean population". Pediatric ... The Centre provide information about specific countries, and maintain a list of Genomic diseases. Specific rare autosomal ... glucose-6-phosphate dehydrogenase deficiency, alpha-thalassemia, molecular characterization, recessive osteoperosis, ... Many of the genetic disorders specific to Arabs are located on HLA segment on chromosome 6. These same segment mutations are ...

https://en.wikipedia.org/wiki/Genetic_studies_on_Arabs

Though the specific cause of the reduced production is not clear, it is believed that the death of medium-sized motor neurons ... The full name of A transferase is alpha 1-3-N-acetylgalactosaminyltransferase and its function in the cell is to add N- ... Herbst EA, MacPherson RE, LeBlanc PJ, Roy BD, Jeoung NH, Harris RA, Peters SJ (Jan 2014). "Pyruvate dehydrogenase kinase-4 ... Due to this, alcohol sulfotransferase is also known by several other names including "hydroxysteroid sulfotransferase," " ...

https://en.wikipedia.org/wiki/Transferase

17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes ... H+ The human 17β-HSD1 isozyme is highly specific for estrogens over androgens whereas the rodent isozyme is less specific. ... "Molecular dissection of a cosmid from a gene-rich region in 17q21 and characterization of a candidate gene for alpha-N- ... "Entrez Gene: HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1". Saloniemi T, Jokela H, Strauss L, Pakarinen P, Poutanen M (2012 ...

https://en.wikipedia.org/wiki/HSD17B1

... in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II". The Journal of Clinical Endocrinology and ... Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific ... developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha ... Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific ...

https://en.wikipedia.org/wiki/Liver_receptor_homolog-1

This is due to its inability to be inactivated by uterine 17β-hydroxysteroid dehydrogenase (17β-HSD). Because of its ... Estradiol is an estrogen, or an agonist of the nuclear estrogen receptors (ERs), the estrogen receptor alpha (ERα) and the ... which require active transport via specific membrane transport proteins to enter cells. The ERs are nuclear receptors that are ... As a result of the alkylation in 17-C position it is not a substrate for 17β dehydrogenase, an enzyme which transforms natural ...

https://en.wikipedia.org/wiki/Pharmacodynamics_of_estradiol

In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17β-hydroxysteroid dehydrogenase to yield ... are transported in water-based blood plasma through specific and non-specific proteins. Specific proteins include sex hormone- ... von der PB, Sarkola T, Seppa K, Eriksson CJ (September 2002). "Testosterone, 5 alpha-dihydrotestosterone and cortisol in men ... which regulates the expression of 17β-hydroxysteroid dehydrogenase. The amount of testosterone synthesized is regulated by the ...

https://en.wikipedia.org/wiki/Testosterone

17β-Hydroxysteroid dehydrogenase deficiency - A condition characterized by impaired androgen and estrogen synthesis in males ... ISBN 978-0-306-46759-2. Legato MJ (2017-05-15). Principles of Gender-Specific Medicine: Gender in the Genomic Era. Academic ... An autosomal recessive condition caused by a mutation of the 5-alpha reductase type 2 gene. It only affects people with Y ... ISBN 978-3-030-29211-9. Lee PA, Nordenström A, Houk CP, Ahmed SF, Auchus R, Baratz A, et al. (2016). "Global Disorders of Sex ...

https://en.wikipedia.org/wiki/Disorders_of_sex_development

... and 20β-hydroxysteroid dehydrogenase in various tissues. In target tissues, particularly the cervix and myometrium, these ... As such, it is not thought to have the same tissue-specific activation and inactivation patterns that progesterone does nor the ... Geller J, Volk H, Lewin M (October 1961). "Objective remission of metastatic breast carcinoma in a male who received 17-alpha ... Caritis SN, Feghali MN, Grobman WA, Rouse DJ (August 2016). "What we have learned about the role of 17-alpha- ...

https://en.wikipedia.org/wiki/Hydroxyprogesterone_caproate

17β-Hydroxysteroid dehydrogenase inhibitors, Flavonols, Topoisomerase inhibitors, Catechols, Vinylogous carboxylic acids). ... the structural genes involved in flavonoid biosynthesis are expressed in specific locations of the plant and at specific times ... including tumor necrosis factor alpha, interleukin 6, and nuclear factor kappa B (NF-κB). The anti-inflammatory action is due ... Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It can be found in many plants, ...

https://en.wikipedia.org/wiki/Fisetin

Blackburn CM, Childs DS (March 1959). "Use of 2 alpha-methyl androstan-17 beta-ol, 3-one (2-methyl dihydrotestosterone) in the ... phase III clinical studies for cachexia but development was ultimately never completed for these indications in these specific ... ISBN 978-0-9828280-1-4. Coutts SB, Kicman AT, Hurst DT, Cowan DA (November 1997). "Intramuscular administration of 5 alpha- ... It has an affinity (Kd) of 0.25 to 0.5 nM for the human AR, which is about 2- to 3-fold higher than that of testosterone (Kd = ...

https://en.wikipedia.org/wiki/Androstanolone

October 1988). "Localisation of 11 beta-hydroxysteroid dehydrogenase--tissue specific protector of the mineralocorticoid ... Zennaro MC, Farman N, Bonvalet JP, Lombès M (May 1997). "Tissue-specific expression of alpha and beta messenger ribonucleic ... corticosteroid 11-beta-dehydrogenase isozyme 2 (a.k.a. 11β-hydroxysteroid dehydrogenase 2; 11β-HSD2), that converts cortisol to ... interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. The ...

https://en.wikipedia.org/wiki/Mineralocorticoid_receptor

Subsequently, 20α-hydroxysteroid dehydrogenase and 20β-hydroxysteroid dehydrogenase reduce these metabolites to form the ... Whether a decrease in progesterone levels is critical for the initiation of labor has been argued and may be species-specific. ... 17-alpha hydroxyprogesterone caproate, and related progestins". American Journal of Obstetrics and Gynecology. 197 (6): 599.e1- ... Progesterone is highly susceptible to enzymatic reduction via reductases and hydroxysteroid dehydrogenases due to its double ...

https://en.wikipedia.org/wiki/Progesterone

Soubhye J, Alard IC, van Antwerpen P, Dufrasne F (2015). "Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the ... However, in another case report, spironolactone was effective in normalizing prostate-specific antigen in a man with prostate ... Serafini PC, Catalino J, Lobo RA (August 1985). "The effect of spironolactone on genital skin 5 alpha-reductase activity". ... Sam KM, Auger S, Luu-The V, Poirier D (1995). "Steroidal spiro-gamma-lactones that inhibit 17 beta-hydroxysteroid dehydrogenase ...

https://en.wikipedia.org/wiki/Pharmacodynamics_of_spironolactone

20-alpha-Dihydroprogesterone 20-alpha-Hydroxysteroid Dehydrogenase 20-beta-Hydroxysteroid Dehydrogenase use Cortisone Reductase ... B-Specific) 3-Aminopropionic Acid use beta-Alanine ... alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha- ... 2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ...

https://decs.bvs.br/I/DeCS2009_Alfab-0a9_ing.htm

Specific Function. Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their ... 17-Beta Hydroxysteroid Dehydrogenase III Deficiency. *Androgen and Estrogen Metabolism. *Androstenedione Metabolism ... Andersson S, Russell DW: Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases ... Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse ...

https://hmdb.ca/proteins/HMDBP00699

3alpha-Hydroxysteroid Dehydrogenase (B-specific). 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase. 5 alpha-3 ... 3alpha-Hydroxysteroid Dehydrogenase (B-specific) Dehydrogenase, 3 alpha-Hydroxysteroid Oxidoreductase, 3 alpha-Hydroxysteroid ... alpha-Hydroxysteroid Dehydrogenase. 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase. 5-DP-3 alpha-HSO. ... 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase - Narrower Concept UI. M0090285. Preferred term. 5 alpha- ...

https://decs.bvsalud.org/en/ths/resource/?id=38201

A-specific) (substance). Code System Preferred Concept Name. 3-alpha-hydroxysteroid dehydrogenase (A-specific) (substance). ...

https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=129931006

The specific crossreaction of antibodies directed against mammalian liver type I 11 beta-hydroxysteroid dehydrogenase (11 beta- ... No dihydrodiol dehydrogenase activity towards trans- or cis-benzene-dihydrodiols could be detected, thus distinguishing it from ... It belongs to the protein superfamily of short-chain dehydrogenases/reductases (SDR) as established by N-terminal sequence ... Along with the 3 alpha-hydroxysteroid dehydrogenase and 3-oxo-reductase activities towards a variety of cis or trans fused A/B ...

https://www.kennedy.ox.ac.uk/publications/108848

https://decs2016.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2019.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2009.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2011.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2017.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2015.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2020.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2010.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2012.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2018.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2014.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

https://decs2013.bvsalud.org/I/DeCS2009_Alfab-0a9_ing.htm

Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new ... 7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase ... This protein is an enzyme, which means that it helps specific ... It is unclear how fatty acid accumulation leads to the specific features of D-bifunctional protein deficiency; however, the ... The protein has two separate regions (domains) with enzyme activity, called the hydratase and dehydrogenase domains. These ...

https://medlineplus.gov/genetics/gene/hsd17b4/

... we used a novel mouse model with a specific ablation of androgen receptor in the adrenal cortex with or without reduction of ... Investigation of 20-α-hydroxysteroid dehydrogenase (20 alpha-HSD, produced by the mouse Akr1c18 gene), an X-zone specific ... 20 alpha-HSD demonstrates a more developed X-zone in Ad-ARKO mice. Protein localisation of 20 alpha-HSD (Red) in the developing ... Hershkovitz, L., Beuschlein, F., Klammer, S., Krup, M. & Weinstein, Y. Adrenal 20α-hydroxysteroid dehydrogenase in the mouse ...

https://www.nature.com/articles/s41598-019-46049-3?error=cookies_not_supported&code=70b48b2d-bb46-4bac-873d-a7f4d91d5f1b

... and 17-beta-hydroxysteroid dehydrogenase type II. These enzymes metabolize relatively weak circulating androgens, such as ... Daniel J Hogan, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American ... it is thought to be specific to the lipophilic cyclosporin A, considering that other immunosuppressants have not been strongly ... Studies have shown that the activity of 5-alpha-reductase is higher in the scalp and facial skin than in other areas, so that ...

https://emedicine.medscape.com/article/1059368-overview

20-alpha-Hydroxysteroid Dehydrogenase [D08.811.682.047.820.284.750] * Aldo-Keto Reductase Family 1 member B10 [D08.811.682.047. ... B-Specific) [D08.811.682.047.820.186] * 3-Isopropylmalate Dehydrogenase [D08.811.682.047.820.193] ... Carbohydrate Dehydrogenases [D08.811.682.047.150] * Sugar Alcohol Dehydrogenases [D08.811.682.047.150.700] * Aldo-Keto ... They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)- ...

https://meshb-prev.nlm.nih.gov/record/ui?ui=D000074408

20-alpha-Dihydroprogesterone. 20-alpha-Hydroxysteroid Dehydrogenase. 20-beta-Hydroxysteroid Dehydrogenase use Cortisone ... Dehydrogenase (B-Specific). 3-Aminopropionic Acid use beta-Alanine ... 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use Testosterone 5-alpha-Reductase ...

https://decs2008.bvsalud.org/I/DeCS2008_Alfab-0a9_ing.htm

... and 17-beta hydroxysteroid dehydrogenases. Leukotrienes and prostaglandins and effectively estimated to have begun in 1935 when ... Rad 140, also known as testolone both male and female doctors will initiate therapy with this version on a specific patient-by- ... What is best for them based on efficacy the half-life of the and 5-beta reductases, 3-alpha and 3-beta hydroxysteroid ...

https://worldsnewsnetwork.com/xt-labs-macrotest-400.html

In the inflamed synovium, cortisol is generated from cortisone by the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme ... 11β-hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in ... a mechanism for tissue-specific regulation of inflammation. Arthritis Res Ther. 2006;8:R108. ... systemic measures of 11β-HSD1 activity that are significantly decreased upon treatment with anti-tumour necrosis factor alpha ( ...

https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-015-0633-2

The Enzyme Collection contains over 550 mAbs that recognize catalytic domains or associated regulatory subunits in enyme complexes

https://dshb.biology.uiowa.edu/collections/enzymes/custitem16/MIgG3,MIgM/custitem40/ELISA,Immunofluorescence

Human 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) ELISA Kit, Cat#EKU02002 ... The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat GSK3A. Standards or samples are ... Human 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) ELISA Kit, Cat#EKU02002 Quick view Wishlist ... Then a biotinylated detection antibody specific for Rat GSK3A and Avidin-Horseradish Peroxidase (HRP) conjugate are added to ...

https://www.biomatik.com/elisa-kits/rat-gsk3-glycogen-synthase-kinase-3-alpha-elisa-kit-cat-eke62130/

Furthermore, an AD-specific protein network was inferred and novel genes potentially associated with AD were identified. By ... and immune response-related module-indicating an AD-specific immune-endocrine-neuronal regulatory network. ... the network features of these AD-related genes were analyzed in the context of human interactome and an AD-specific network was ... Major histocompatibility complex, class II, DQ alpha 1 HSD17B14 Hydroxysteroid (17-beta) dehydrogenase 14 ...

https://alzres.biomedcentral.com/articles/10.1186/s13195-017-0252-z/tables/2

We use steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) as a reporter system to study ... In support of this, we were unahle to detect specific intracellular binding of Testosterone. These findings sbow that ... We use steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase (3alpha-HSD/CR) as a reporter system to study ... 17β-Hydroxysteroid dehydrogenase (3,17β-HSD) from C. testosteroni is a Testosterone-inducible protein and a key enzyme in ...

https://www.idexlab.com/openisme/topic-testosterone/

J Transl Med 2013; 11:167 Intratumoral localization and activity of 17β-hydroxysteroid dehydrogenase type 1 in non-small cell ... Eur J Surg Oncol 2004; 30 (5):469-74 Estrogen receptor alpha and beta profiling in human breast cancer. Application : IHC ... PLoS One 2009; 4 (7):e6271 Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta- ... Urology 2004; 63 (2):382-6 Estrogen and phytoestrogen predispose to erectile dysfunction: do ER-alpha and ER-beta in the ...

https://www.genetex.com/Product/Detail/Estrogen-Receptor-beta-antibody-14C8/GTX70174

Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. (medlineplus.gov)
The activities of estradiol 17beta-hydroxysteroid dehydrogenase and estrone sulfatase are all increased by IL-6. (atlasgeneticsoncology.org)

The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH . (bvsalud.org)
This protein is an enzyme, which means that it helps specific biochemical reactions take place. (medlineplus.gov)
The protein has two separate regions (domains) with enzyme activity, called the hydratase and dehydrogenase domains. (medlineplus.gov)
In the inflamed synovium, cortisol is generated from cortisone by the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. (biomedcentral.com)
3,17β-Hydroxysteroid dehydrogenase (3,17β-HSD) from C. testosteroni is a Testosterone -inducible protein and a key enzyme in steroid degradation. (idexlab.com)
In terms of tissue-specific cortisol metabolism, it is said that the enzyme 11 beta - hydroxysteroid dehydrogenase type 1 (11B-HSD1) is relevant in HPA axis activity, regenerating active cortisol from its inactive forms intracellularly. (mindbodyfunctionalmedicine.com)
As with most single enzyme disorders, 5-alpha-reductase type 2 deficiency is an autosomal recessive trait and sex limited because the clinical syndrome only affects genetic males, with very subtle phenotypic findings in homozygous females. (medscape.com)
Its product is expressed only in nongenital skin and liver at low levels from the time the individual is aged 3 years until puberty, at which time enzyme expression is measurable in sebaceous glands and scalp. (medscape.com)
Linkage analysis has demonstrated that the type 1 enzyme is unrelated to the clinical syndrome of 5-alpha-reductase type 2 deficiency. (medscape.com)
Interestingly, partial virilization of males with 5-alpha-reductase type 2 deficiency occurs at puberty and may be attributable to the rise in type 1 enzyme activity or expression at that time. (medscape.com)
More than 60 different mutations of the gene for 5-alpha-reductase type 2 have been reported in people with clinical and biochemical evidence of the enzyme deficiency. (medscape.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) in tissue homogenates, cell lysates and other biological fluids. (lipidx.org)
This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. (abnova.com)

Mouse anti Human AKR1C1 antibody detects the aldo-keto reductase family 1 member C1, also known as 20-alpha-hydroxysteroid dehydrogenase (20-alpha-HSD), chlordecone reductase homolog HAKRC and high-affinity hepatic bile acid-binding protein (HBAB). (bio-rad-antibodies.com)

Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (genetex.com)
29 (1) : 3 Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression. (genetex.com)
Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). (ucsc.edu)

Aldo-keto reductase family 1 member C1 catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. (bio-rad-antibodies.com)

No dihydrodiol dehydrogenase activity towards trans- or cis-benzene-dihydrodiols could be detected, thus distinguishing it from the indomethacine-sensitive, mammalian liver type 3 alpha-HSDs. (ox.ac.uk)

These include α1 acid glycoprotein, serum amyloid A, the C-reactive protein homolog pentraxin-3, the lipocalin 24p3, and a host of cytokines ( 17 ). (diabetesjournals.org)

3-hydroxy-3-methylglutaryl-CoA synthase. (gsea-msigdb.org)

It belongs to the protein superfamily of short-chain dehydrogenases/reductases (SDR) as established by N-terminal sequence analysis. (ox.ac.uk)
Identification and isolation of a regulator protein for 3,17β-HSD expressional regulation in Comamonas testosteroni. (idexlab.com)
Upon examining the genome with bioinformatics tools, a gene (brp) coding for a regulator protein (BRP) for 3,17β-HSD expression was found upstream of the βhsd gene. (idexlab.com)
The foetal brain is protected against the effect of circulating oestrogens from the mother by the protein fetoprotein, which is produced by the foetus and binds strongly to oestrogens but not to testosterone (3,4). (blogspot.com)
Hydroxysteroid (17beta) dehydrogenase X (HSD10) is a multifunctional protein encoded by the HSD17B10 gene at Xp11.2. (biomedcentral.com)
G protein nucleolar 3 [Source:HGNC Symb. (gsea-msigdb.org)
Relative gene expression was determined for testicular nucleotide oligomerization domain (NOD)-like receptors proteins and Caspase-1, and autophagy markers including microtubule-associated protein 1 light chain 3 alpha and Beclin-1. (oszk.hu)
While storage and release of lipids are major functions of adipocytes, the adipocyte also uses specific lipid molecules for intracellular signaling and uses a host of protein factors to communicate with essentially every organ system in the body. (diabetesjournals.org)
Additional proteins have joined this exclusive club of adipocyte-specific secretory proteins since then, including adipokines such as resistin ( 11 , 12 ) and acylation-stimulating protein ( 13 ), as well as the recently described visfatin ( 14 , 15 ) and retinol-binding protein-4 ( 16 ). (diabetesjournals.org)

The broad substrate specificities of the characterized 3 alpha-HSD enzymes lead to the conclusion that they might participate in the intestinal bioactivation or inactivation of hormones, bile acids and xenobiotics since Comamonas testosteroni and related species are found in the intestinal tract of vertebrates including man. (ox.ac.uk)
Sebocytes contain androgen-metabolizing enzymes, including 5-alpha-reductase type I, 3-beta-hydroxysteroid dehydrogenase, and 17-beta-hydroxysteroid dehydrogenase type II. (medscape.com)

Construction of a biosensor mutant of Comamonas testosteroni for Testosterone determination by cloning the EGFP gene downstream to the regulatory region of the 3,17β-HSD gene. (idexlab.com)
We found that a 2.4 kb regulatory DNA fragment upstream of the 3,17β-HSD gene (βhsd) responds to steroids and triggers βhsd gene induction. (idexlab.com)
After integration of pK2.4-EGFP-4 into the βhsd gene promoter, 3,17β-HSD expression could not be induced such that EGFP expression in the mutant cells was at low levels. (idexlab.com)
Elucidating the mechanism of 3,17β-HSD gene (βhsd) regulation may help us to generate prospective C. testosteroni mutants for bioremediation. (idexlab.com)
These knock-out mutants showed an enhanced expression of both the βhsd gene and the hsdA gene (the latter coding for 3α-HSD/CR) in the presence of Testosterone . (idexlab.com)
This gene is a member of the retinol dehydrogenase family. (ucsc.edu)
Chromosomal DNA was isolated from blood samples of normal individuals (one male and two females) with the FlexiGene kit ( http://www.qiagen.com ) and used as the template for the HSD17B10 gene-specific methylation analysis. (biomedcentral.com)
Only the genes coding for 5-alpha-reductase type 1 (SRD5A1) and 5-alpha-reductase type 2 (SRD5A2) are pertinent to the conversion of testosterone to DHT, whereas the gene coding 5-alpha-reductase type 3 is unrelated to any disorders of male sexual development, and may be implicated in a rare disorder of glycosylation. (medscape.com)
7, 8] The gene for 5-alpha-reductase type 2 has been determined to be on band 2p23. (medscape.com)
Lack of expression of this gene clinically correlates with the symptoms of 5-alpha-reductase type 2 deficiency. (medscape.com)
The gene for 5-alpha-reductase type 1 is located on band 5p15. (medscape.com)
Recent studies indicate that the developing brain shows sex-specific differences in gene expression prior to gonadal hormone action. (biomedcentral.com)

The specific crossreaction of antibodies directed against mammalian liver type I 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD I) with the isolated 3 alpha-HSDs suggests the existence of a functionally and structurally related subgroup within the SDR superfamily. (ox.ac.uk)
collagen type VIII alpha 1 chain [Sourc. (gsea-msigdb.org)
5-Alpha-reductase type 2 deficiency (5-ARD) is an autosomal recessive sex-limited condition resulting in the inability to convert testosterone to the more physiologically active dihydrotestosterone (DHT). (medscape.com)
Because DHT is required for the normal masculinization of the external genitalia in utero, genetic males with 5-alpha-reductase type 2 deficiency are born with ambiguous genitalia (ie. (medscape.com)
Patients with 5-alpha-reductase type 2 deficiency classically present with striking ambiguity of the genitalia, with a clitoral-like phallus, bifid scrotum, pseudovaginal perineoscrotal hypospadias, and a rudimentary prostate. (medscape.com)
The cause of 5-alpha-reductase type 2 deficiency is the deficiency of the type 2 isozyme of 5-alpha-reductase. (medscape.com)
The root cause of this disorder is a deficiency in the 5-alpha-reductase type 2 isoenzyme, which transforms testosterone to DHT. (medscape.com)
The 5-alpha-reductase type 2 isoenzyme is expressed in external genital tissues early in gestation, making its action necessary for the development of normal male external genital anatomy in the fetus. (medscape.com)
Biochemical effects of 5-alpha-reductase type 2 deficiency in testosterone biosynthesis. (medscape.com)
In adulthood, the 5-alpha-reductase type 2 isoenzyme is expressed in high levels in the prostate, genital skin, epididymis, seminal vesicle, and liver. (medscape.com)

Along with the 3 alpha-hydroxysteroid dehydrogenase and 3-oxo-reductase activities towards a variety of cis or trans fused A/B ring steroids, it also reduces several xenobiotic carbonyl compounds, including a metyrapone-based class of insecticides, to the respective alcohol metabolites. (ox.ac.uk)
Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). (ucsc.edu)
7. Epiandrosterone can also be converted from the natural steroids androstanediol via 17β -hydroxysteroid dehydrogenase or fromandrostanedione via 3β -hydroxysteroid dehydrogenase. (medical-steroids.com)

The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. (ucsc.edu)

The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells. (uni.lu)

La enzima es B-específica, en referencia a la orientación del NAD reducido o NADPH. (bvsalud.org)

Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas testosteroni. (ox.ac.uk)
A new form of the NAD(P)-dependent 3 alpha-hydroxysteroid dehydrogenases (3 alpha-HSDs), present in the gram-negative bacterium Comamonas testosteroni ATCC 11996, was isolated from a testosterone-induced bacterial extract and characterized. (ox.ac.uk)
Proteins similar to the 3 alpha-HSD were detected and characterized from Comamonas testosteroni strain ATCC 17454 and from a commercially available steroid-induced extract of a patent Pseudomonas strain. (ox.ac.uk)
However, no similarities could be detected between HSD 28 and a recently determined 3 alpha-HSD sequence from the ATCC 11996 Comamonas strain. (ox.ac.uk)

3,17β-HSD is a member of the short-chain dehydrogenase/reductase (SDR) superfamily. (idexlab.com)

High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling. (abnova.com)

It has repeatedly shown that oncogenic mutations as well as the bone marrow matrix (BMM) stimulate IL-6-independent signalling pathways that protect MM cells from apoptosis.Hyperdiploid MM tumors contain multiple trisomies involving chromosomes 3, 5, 7, 9, 11, 15 , 19 , and 21, but rarely have IgH translocations, although CCND-1 / CCND-2 / CCND-3 dysregulation appears to occur as an early event. (atlasgeneticsoncology.org)

Emerging evidence suggests a novel role for PMCAs as regulators of calcium/calmodulin-dependent signal transduction pathways via interaction with specific partner proteins. (uni.lu)
Growth factors activating the phosphatidylinositol (PI)-3 kinase/AKT and MAP kinase pathways, and - B-cell-activating factor ( BAFF ) or proliferation-inducing ligand ( APRIL ). (atlasgeneticsoncology.org)

A Western blot assay was used to determine the expression of apoptotic proteins and Nod-like receptor 3 (NLRP3) pathway proteins in the retina of DR rats. (oszk.hu)
This leads to a dysregulation of triglyceride and free fatty acid levels, as well as a dysregulation of specific adipocyte-derived secretory proteins, a group of proteins that we refer to as adipokines. (diabetesjournals.org)

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. (hmdb.ca)
Studies have shown that the activity of 5-alpha-reductase is higher in the scalp and facial skin than in other areas, so that testosterone and dihydrotestosterone stimulate more sebaceous gland proliferation in these areas. (medscape.com)
In patients with 5-alpha-reductase deficiency who are raised as male, testosterone or dihydrotestosterone (DHT) therapy may increase penile length. (medscape.com)
In summary, this new biosensor system might be used for the specific determination of Testosterone . (idexlab.com)
Testosterone + NAD(+) = androst-4-ene-3,17- dione + NADH. (ucsc.edu)
On the other hand, in males, testosterone masculinizes the developing brain, either directly through the activation of the androgen receptor (AR) or indirectly via the stimulation of estrogen receptors (ER) following the conversion of T into E2 [ 3 , 40 ]. (biomedcentral.com)

En la fermentación alcohólica cataliza el paso final de reducción de un aldehído a un alcohol en presencia de NADH e hidrógeno. (bvsalud.org)

Three genes coding for 5-alpha-reductase have been identified, each for a slightly different isoenzyme. (medscape.com)

Androsterone is the 3-alpha isomer and epiandrosterone is the 3-beta isomer of this compound. (medical-steroids.com)

Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). (ucsc.edu)

To investigate AR-dependent and AR-independent androgen signalling in the adrenal, we used a novel mouse model with a specific ablation of androgen receptor in the adrenal cortex with or without reduction of circulating androgen levels by castration. (nature.com)
3 (1) : vdab099 Histone deacetylase inhibitors enhance estrogen receptor beta expression and augment agonist-mediated tumor suppression in glioblastoma. (genetex.com)

The N-terminal amino acid sequence of the 3 alpha-HSD from the latter strain (HSD 29) is highly similar (94% identity over 15 residues) to a previously determined primary structure of a Pseudomonas species 3 alpha-HSD. (ox.ac.uk)

Belongs to the short-chain dehydrogenases/reductases (SDR) family. (ucsc.edu)

In conditions where androgen response or synthesis leads to a DSD, such as partial androgen insensitivity syndrome (PAIS), 17-beta-hydroxysteroid dehydrogenase deficiency, and 5-alpha-reductase deficiency (5-ARD), attaining all of these goals is unlikely. (medscape.com)
In select cultures with high prevalence of 5-alpha-reductase deficiency, such as the Dominican Republic and Papua New-Guinea, gender role change is an accepted part of culture. (medscape.com)

It is a conjugated steroid converted by the sulfation of dehydroepiandrosterone (DHEA) at the 3β position via hydroxysteroid sulfotransferase. (cdc.gov)

Other melanocyte-stimulating hormones produced by the pituitary and other tissues include alpha-MSH (contained within the ACTH molecule), beta-MSH, and gamma-MSH. (medscape.com)

The decision to follow the testis or ovary pathway is primarily governed by the chromosome constitution (XX/XY), which was established while studying human sex-related diseases [ 2 , 3 ]. (biomedcentral.com)

In this systematic review, we highlight the differences between the male and female zebrafish brains to understand their differentiation and their use in studying sex-specific neurological diseases. (biomedcentral.com)
Understanding the signaling mechanisms involved in brain sex differentiation could help further elucidate the sex-specific incidences of certain neurological diseases. (biomedcentral.com)

Among these metabolites, significant attention happens to be being concentrated upon the inositol pyrophosphates (PP-InsPs), the distinguishing feature which is the ownership of high-energy diphosphate groupings on the 1- and/or 5-positions from the six carbons that comprise the inositol band [3,4]. (immune-source.com)

The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat GSK3A. (biomatik.com)
Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. (biomatik.com)
Then a biotinylated detection antibody specific for Rat GSK3A and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. (biomatik.com)

It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. (bvsalud.org)
Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). (ucsc.edu)

and specific metabolic abnormalities relating to thyroid, parathyroid and adrenal gland function (much of pediatric diabetes is directed elsewhere within the hospital but some cases are referred to Endocrinology). (medscape.com)

Power of performed test with alpha = 0.050: 0.839). (healthweblognews.info)

3-hidroxiesteroide-deshidrogenasa que cataliza la reducción reversible de la DIHIDROTESTOSTERONA, un andrógeno activo, para formar 5-ALFA-ANDROSTANO-3 ALFA,17 BETA-DIOL. (bvsalud.org)
A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. (bvsalud.org)
They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 ( BETA SHEET )-alpha 8 ( ALPHA HELICES )-barrel structure that contains the NADP binding site. (nih.gov)
Homo sapiens hydroxysteroid 17-beta dehydrogenase 6 (HSD17B6), mRNA. (ucsc.edu)

Anatomy3

Diseases3

Chemicals and Drugs64

Phenomena and Processes7

Information Science3

Hydroxysteroid Dehydrogenases

3-Hydroxysteroid Dehydrogenases

17-Hydroxysteroid Dehydrogenases

20-Hydroxysteroid Dehydrogenases

3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)

11-beta-Hydroxysteroid Dehydrogenase Type 2

11-beta-Hydroxysteroid Dehydrogenase Type 1

11-beta-Hydroxysteroid Dehydrogenases

Paraganglioma, Extra-Adrenal

L-Lactate Dehydrogenase

Lactate Dehydrogenases

Estradiol Dehydrogenases

Succinate Dehydrogenase

Sulfotransferases

Paraganglioma

Cortisone

Steroid 17-alpha-Hydroxylase

Alcohol Oxidoreductases

Steroids

NAD

Isoenzymes

Hydrocortisone

Kinetics

Testosterone

Liver

Androsterone

Alcohol Dehydrogenase

Glyceraldehyde-3-Phosphate Dehydrogenases

20-alpha-Hydroxysteroid Dehydrogenase

Aldehyde Dehydrogenase

Glutamate Dehydrogenase

Glucosephosphate Dehydrogenase

Malate Dehydrogenase

Isocitrate Dehydrogenase

Phosphoadenosine Phosphosulfate

Arylsulfotransferase

Ketosteroids

NADP

Dihydrolipoamide Dehydrogenase

Carbohydrate Dehydrogenases

L-Iditol 2-Dehydrogenase

Molecular Sequence Data

Dehydroepiandrosterone

Glycerolphosphate Dehydrogenase

Substrate Specificity

Glucose 1-Dehydrogenase

Amino Acid Sequence

Base Sequence

Ketoglutarate Dehydrogenase Complex

Aldehyde Oxidoreductases

Stereoisomerism

Gene Expression Regulation, Enzymologic

Glucose Dehydrogenases

Phosphogluconate Dehydrogenase

Sugar Alcohol Dehydrogenases

Acyl-CoA Dehydrogenases

NADH Dehydrogenase

IMP Dehydrogenase

Acyl-CoA Dehydrogenase

Formate Dehydrogenases

Xanthine Dehydrogenase

alpha 1-Antitrypsin

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)

Hydroxybutyrate Dehydrogenase

Recombinant Proteins

3-Hydroxyacyl CoA Dehydrogenases

Pyruvate Dehydrogenase (Lipoamide)

Ketone Oxidoreductases

Oxidoreductases

RNA, Messenger

Catalysis

Sulfates

Dihydrouracil Dehydrogenase (NADP)

Uridine Diphosphate Glucose Dehydrogenase

Cytosol

Glucosephosphate Dehydrogenase Deficiency

Placenta

Receptors, Adrenergic, alpha

AKR1C3

3alpha-hydroxysteroid dehydrogenase (A-specific)