Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.3',5'-Cyclic-AMP Phosphodiesterases: Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.Cyclic Nucleotide Phosphodiesterases, Type 4: A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.Phosphodiesterase Inhibitors: Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Miller Fisher Syndrome: A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Cyclic Nucleotide Phosphodiesterases, Type 3: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.Phosphoric Diester Hydrolases: A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.3',5'-Cyclic-GMP Phosphodiesterases: Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.Rod Cell Outer Segment: The portion of a retinal rod cell situated between the ROD INNER SEGMENT and the RETINAL PIGMENT EPITHELIUM. It contains a stack of photosensitive disk membranes laden with RHODOPSIN.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Cyclic Nucleotide Phosphodiesterases, Type 6: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.Cyclic Nucleotide Phosphodiesterases, Type 5: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.Transducin: A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells. EC 3.6.1.-.Photoreceptor Cells, Vertebrate: Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.Retinal Rod Photoreceptor Cells: Photosensitive afferent neurons located in the peripheral retina, with their density increases radially away from the FOVEA CENTRALIS. Being much more sensitive to light than the RETINAL CONE CELLS, the rod cells are responsible for twilight vision (at scotopic intensities) as well as peripheral vision, but provide no color discrimination.Biofilms: Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.Acyl-Butyrolactones: Cyclic esters of acylated BUTYRIC ACID containing four carbons in the ring.4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.HomoserineQuorum Sensing: A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.Pentanones: 5-carbon straight-chain or branched-chain ketones.Carbon-Sulfur Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2.Lactones: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.Mouth: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.Hafnia alvei: The type species for the genus HAFNIA. It is distinguished from other biochemically similar bacteria by its lack of acid production on media containing sucrose. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Cyclic Nucleotide Phosphodiesterases, Type 1: A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.Cyclic Nucleotide Phosphodiesterases, Type 2: A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.Guanylyl Imidodiphosphate: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.Doxycycline: A synthetic tetracycline derivative with similar antimicrobial activity.Microtomy: The technique of using a microtome to cut thin or ultrathin sections of tissues embedded in a supporting substance. The microtome is an instrument that hold a steel, glass or diamond knife in clamps at an angle to the blocks of prepared tissues, which it cuts in sections of equal thickness.Tissue Embedding: The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Mice, Inbred C57BLMice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Adaptation, Physiological: The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Gravity Sensing: Process whereby a cell, bodily structure, or organism (animal or plant) receives or detects a gravity stimulus. Gravity sensing plays an important role in the directional growth and development of an organism (GRAVITROPISM).Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
*  3',5'-cyclic-GMP phosphodiesterase
... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'- ... Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase. As of ...
*  List of MeSH codes (D08)
... cyclic-GMP phosphodiesterase MeSH D08.811.277.352.640.150 --- 3',5'-cyclic-nucleotide phosphodiesterase MeSH D08.811.277.352. ... cyclic gmp-dependent protein kinases MeSH D08.811.913.696.620.682.700.150.575 --- protamine kinase MeSH D08.811.913.696.620.682 ... cyclic-nucleotide phosphodiesterases MeSH D08.811.277.352.640.295 --- glycerophosphoinositol inositolphosphodiesterase MeSH ... cyclic nucleotide-regulated protein kinases MeSH D08.811.913.696.620.682.700.150.125 --- cyclic amp-dependent protein kinases ...
*  Phosphodiesterase 2
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... June 1997). "cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes ... Bender AT, Beavo JA (September 2006). "Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use". Pharmacol. ... The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs ...
*  PDE11A
... cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclic ... Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ...
*  Diguanylate cyclase
... cyclic di-GMP). Degradation of cyclic di-GMP to guanosine monophosphate (GMP) is catalyzed by a phosphodiesterase (PDE). ... Cyclic di-GMP binds to interface between the DGC and D2 domains stabilizing the open structure and preventing catalysis. Strong ... Often, GGDEF domains with DGC activity are found in the same proteins as c-di-GMP-specific phosphodiesterase (PDE) EAL (Glu-Ala ... D'Argenio, D.A.; Miller, S.I. (2004). "Cyclic di-GMP as a bacterial second messenger". Microbiology. 150 (Pt 8): 2497-502. doi: ...
*  List of EC numbers (EC 3)
... cyclic-GMP phosphodiesterase EC 3.1.4.36: now with EC 3.1.4.43 EC 3.1.4.37: 2',3'-cyclic-nucleotide 3'-phosphodiesterase EC 3.1 ... CMP-N-acylneuraminate phosphodiesterase EC 3.1.4.41: sphingomyelin phosphodiesterase D EC 3.1.4.42: glycerol-1,2-cyclic- ... glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase EC 3.1.4.52: cyclic-guanylate-specific phosphodiesterase EC 3.1.4.53 ... cyclic-nucleotide phosphodiesterase EC 3.1.4.18: now EC 3.1.16.1 EC 3.1.4.19: now EC 3.1.13.3 EC 3.1.4.20: now EC 3.1.13.1 EC ...
*  Cyclic guanosine monophosphate
Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP ... Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second ... cyclic monophosphate (8-Br-cGMP) Francis SH, Corbin JD (August 1999). "Cyclic nucleotide-dependent protein kinases: ... Phosphodiesterase inhibitors prevent the degradation of cGMP, thereby enhancing and/or prolonging its effects. For example, ...
*  MY-5445
... a Specific Inhibitor of Cyclic GMP Phosphodiesterase, on Human Platelet Aggregation". The Journal of Pharmacology and ... Aubin, C; Webster, L; Rebeyka, IM; Ross, DB; Light, PE; Dyck, JR; Michelakis, ED (17 July 2007). "Phosphodiesterase Type 5 is ... MY-5445 is a relatively specific phosphodiesterase 5 inhibitor. Vatalanib - a structurally related angiogenesis inhibitor ... and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility" (PDF). Circulation. 116 (3): 238-48. doi:10.1161/ ...
*  GAF domain
Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor. EMBO J.. 2000;19(20):5288-99 ... In mammals, GAF domains are found in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 ... The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc. Natl. Acad. Sci. U.S ... The GAF domain is named after some of the proteins it is found in: cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA ...
*  Cyclic nucleotide
The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ... As can be seen in the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) images, the 'cyclic' ...
*  CGAS-STING cytosolic DNA sensing pathway
Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... phosphodiesterases. Other advantages of the unique 2'-5' linkage may be that cGAMP is able to bind multiple allelic variants of ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... "Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses". Science 23 August 2013: Vol. 341 no. 6148 pp ...
*  PRKG1
"Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell ... and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP". The Journal of Biological ... 96 (5): 2467-72. doi:10.1073/pnas.96.5.2467. PMC 26808 . PMID 10051666. Wang X, Bruderer S, Rafi Z, Xue J, Milburn PJ, Krämer A ... 27 (3 Pt 2): 552-7. doi:10.1161/01.hyp.27.3.552. PMID 8613202. Salih E, Zhou HY, Glimcher MJ (Jul 1996). "Phosphorylation of ...
*  Retinitis pigmentosa GTPase regulator
... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... 38 (13): 2750-5. PMID 9418727. Yan D, Swain PK, Breuer D, Tucker RM, Wu W, Fujita R, Rehemtulla A, Burke D, Swaroop A (Jul 1998 ... 5 (7): 1035-41. doi:10.1093/hmg/5.7.1035. PMID 8817343. Murga-Zamalloa CA, Atkins SJ, Peranen J, Swaroop A, Khanna H (Sep 2010 ...
*  PDE6D
Linari M, Hanzal-Bayer M, Becker J (Sep 1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, ... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the ... cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene. PDE6D was originally ...
*  Cyclic-guanylate-specific phosphodiesterase
... c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an ... Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3->5')diguanylate phosphodiesterase, ... "Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP". J. Biol. ... Cyclic-guanylate-specific phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular ...
*  Cyclic nucleotide phosphodiesterase
Kroll S, Phillips WJ, Cerione RA (March 1989). "The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the ... 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17, cyclic 3',5'-mononucleotide phosphodiesterase, PDE, cyclic 3',5'- ... monophosphate phosphodiesterase (cyclic CMP), cyclic 3',5-nucleotide monophosphate phosphodiesterase, nucleoside 3',5'-cyclic ... cyclic CMP As per Andrew T. Bender and Joseph A. Beavo, there are 11 distinct phosphodiesterase families (PDE1-PDE11) with a ...
*  Biological functions of nitric oxide
... cyclic GMP) from guanosine triphosphate (GTP). The soluble cGMP activates cyclic nucleotide-dependent protein kinase G (PKG or ... This is the biological basis of sildenafil (Viagra), which works to inhibit the enzyme phosphodiesterase PDE5, which lowers the ... 5 (6): 417-471. PMID 10390607. Radicals for life: The various forms of nitric oxide. E. van Faassen and A. Vanin, eds. Elsevier ... 5 (6): 417-41. PMID 10390607. Gu, Qilin; Yang, Xiaojie; Lin, Li; Li, Shaoyang; Li, Qing; Zhong, Shan; Peng, Jinrong; Cui, ...
*  Discovery and development of phosphodiesterase 5 inhibitors
Cyclic GMP binds to the cGMP-dependent protein kinase (PKG1) which phosphorylates several proteins that results in decreased ... Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... GMP is an inactive molecule with no second messenger activity. Phosphorylation of a single serine by PKG1 and the allosteric ...
*  PDE6A
... cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene. PDE6A encodes the cyclic-GMP ( ... cGMP) specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 ... "Entrez Gene: PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha". Pittler SJ, Baehr W (1991). "The molecular genetics of ... Catty P, Pfister C, Bruckert F, Deterre P (1992). "The cGMP phosphodiesterase-transducin complex of retinal rods. Membrane ...
*  Sildenafil
... protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in ... Phosphodiesterase inhibitors (e.g., sildenafil) can also improve [Raynaud's phenomenon] symptoms and ulcer healing "Viagra and ... Laties, AM (January 2009). "Vision Disorders and Phosphodiesterase Type 5 Inhibitors: a Review of the Evidence to Date". Drug ... Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for ...
*  Phosphodiester bond
... for instance a bond in a molecule of cyclic AMP or cyclic GMP. An enzyme that plays an important role in the repair of ... Phosphodiesterase Phosphodiesterase inhibitor DNA replication, DNA, ATP Teichoic acid, DNase I PDE5 Nick (DNA) Even prions, the ... A phosphodiesterase is an enzyme that catalyzes the hydrolysis of phosphodiester bonds, ... phosphodiesterase. During the replication of DNA, there is a hole between the phosphates in the backbone left by DNA polymerase ...
*  ARL3
Linari M, Hanzal-Bayer M, Becker J (1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, ... 377 (6547 Suppl): 3-174. PMID 7566098. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" ... ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene. ADP-ribosylation factor-like 3 ... 83 (3-4): 246. doi:10.1159/000015194. PMID 10072593. Check date values in: ,year= / ,date= mismatch (help) "Entrez Gene: ARL3 ...
*  PDE6G
1993). "Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of ... "The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase" [The organization of the gamma- ... subunit gene of human photoreceptor cyclic GMP phosphodiesterase]. Doklady Akademii Nauk SSSR. 315 (1): 229-31. PMID 1965799. ... of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase". ...
*  PDE5 inhibitor
"Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in ... "Differential Activation and Inhibition of the Multiple Forms of Cyclic Nucleotide Phosphodiesterase". Advances in Cyclic ... Weiss, B; Hait, W N (1977). "Selective Cyclic Nucleotide Phosphodiesterase Inhibitors as Potential Therapeutic Agents". Annual ... Fertel, Richard; Weiss, Benjamin (1976). "Properties and Drug Responsiveness of Cyclic Nucleotide Phosphodiesterases of Rat ...
*  Icariin
2006). "Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5 ... Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS (2006). "Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic ... 2008). "Potent inhibition of human phosphodiesterase-5 by icariin derivatives". J. Nat. Prod. 71 (9): 1513-1517. doi:10.1021/ ... 114 (3): 412-416. doi:10.1016/j.jep.2007.08.021. PMID 17890032. Xiao H, Wignall N, Brown ES (2016). "An open-label pilot study ...
*  Sperm chemotaxis
Cyclic GMP possibly opens cyclic nucleotide-gated (CNG) K+-selective channels, thereby causing hyperpolarization of the ... The cGMP signal is terminated by the hydrolysis of cGMP through phosphodiesterase (PDE) activity and inactivation of GC. On ... Yoshida, M., Inaba, K., Ishida, K. and Morisawa, M. (1994) Calcium and cyclic AMP mediate sperm activation, but Ca2+ alone ... The consequential hyperpolarization activates hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. The ...
... (SEO) is the process of affecting the visibility of a website or a web page in a web search engines unpaid results-often referred to as natural, organic, or earned results. In general, the earlier (or higher ranked on the search results page), and more frequently a site appears in the search results list, the more visitors it will receive from the search engines users, and these visitors can be converted into customers. SEO may target different kinds of search, including image search, local search, video search, academic search, news search and industry-specific vertical search engines.

As an Internet marketing strategy, SEO considers how search engines work, what people search for, the actual search terms or keywords typed into search engines and which search engines are preferred by their targeted audience. Optimizing a website may involve editing its content, HTML and associated coding to both increase its relevance to specific keywords and to remove barriers
Job Search Engine Veterinary Jobs in Hong-Kong | TerritorioScuola Job Search Engine Hong-Kong | TerritorioScuola Job Search Engine | TerritorioScuola Job Search Engine You can search for thousands of jobs in US with our powerful search engine.
A minimum of 75% of Web users uses internet search engine to locate information, product, and services. These customers get to the website after an active research study. For that reason, these do not only represent hits, yet prospective clients.. Internet search engine promotion involves advertising your site through numerous online networks to raise presence as well as your capacity to get a greater web page position or setting within the online search engine results from web pages. Typical search engine promo campaigns include article advertising, press release, optimization and submissions.. Internet search engine promo is the process of enhancing positions, site visitor numbers and also making use of online search engine to advertise brand name understanding. Every activity whose purpose is to promote a site and also offer hits via search engines comes under the orb of Internet search engine promotion.. Search Engine Promotion is developed to build upon the Online search engine ...
A search engine configured to search a database of documents and provide search results to an end user is described. The search engine may be configured to provide the end user with a list of synonyms for terms in the search query submitted by the end user and allow the end user to identify those synonyms which should be included in the search engine. Alternatively or additionally, the search engine may be configured to provide the end user with survey questions, the answers to which, may be used to further define the search query. The database may include notes and/or advertisements that are associated with specific documents in the database.
A web search engine is a software system that is designed to search for information on the World Wide Web. The search results are generally presented in a line of results often referred to as search engine results pages (SERPs). The information may be a mix of web pages, images, and other types of files. Some search engines also mine data available in databases or open directories. Unlike web directories, which are maintained only by human editors, search engines also maintain real-time information by running an algorithm on a web crawler.
Original Message----- , From: Marc G. Fournier [mailto:scrappy(at)postgresql(dot)org] , Sent: 30 January 2004 20:49 , To: Dave Page , Cc: Oleg Bartunov; pgsql-www(at)postgresql(dot)org , Subject: Re: [pgsql-www] Postgresql.org search engine. , , k, this is how the search engines should see each message when they , index: , , http://archives.postgresql.org/pgsql-hackers/2004-01/msg00745t.php , , anything else youd like me to strip out of there? :( , , Note that this is not with the ,!--noindex--, stuff you were , talking about, which, from what youve said, Im not sure is , useful, since not all search engines will recognize it ... , with the way its coded now, as long as I have the search , engine listed, the output will look the same ... As I pointed out before, the problem with that is that search engines like Google or search.postgresql.org that cache the pages wont get any of the thread navigation and other elements of the page. Id rather see the ,!--noindex--, bits (or at very least, ...
The invention relates to directing one or more object-based search engines to an object store, which stores information archived according to parametric classifiers. In order for the object-based search engine to access the objects, a special index class, in the form of a SQL table is created. The index class comprises attributes of a part number, an object identification number, an item identifier, a search state attribute, and a search engine identifier, an object being assigned a corresponding value for each attribute and each object being uniquely identified by the item identifier attribute. The search engine is activated depending on the type of data object to be indexed, in accordance with the search state attribute the catalog table. A computer readable medium is provided with program code to implement the above integration.
1. Premium Search Engine - You can access BioMedLibs search engine free of charge at www.bmlsearch.com . On the other hand you can subscribe with a low fee for the premium search engine; it is faster and it comes with PDF fulltext service. Plus you are helping BioMedLib to continue providing you with these services. Subscribe to Premium BioMedLib Search Engine ...
Get an online background check instant in any state, county or city of United States. Osceola County Florida Court Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Criminal Records In California Search.
Get an online background check instant in any state, county or city of United States. York County Maine Court Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Public Record Search Leon County Florida.
Get an online background check instant in any state, county or city of United States. Galveston County Criminal Court Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. How Long Does It Take To Do A Background Check For A Gun.
Get an online background check instant in any state, county or city of United States. Nebraska Public Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Open Public Records Search Ocean County Nj.
0017] Predicting the popularity of items may impact revenues of network-based services such as, for example, shopping search engines. Accordingly, prediction of item popularity may be performed by, for example, one or more network-based systems (e.g., commerce systems, publication systems, listing systems, media archival systems, image sharing systems, visual search engines, shopping search engines, or any suitable combination thereof), and in some particular examples, by one or more popularity prediction machines included in one or more of such network-based systems. Considering the example context of a shopping search engine, a potential difference between a shopping search engine and a generic web search engine is that a shopping search result often includes thumbnail images of the items in the search result page. Another potential difference between a shopping search and a generic web search is that search results from the former typically include images along with potentially ...
According to our clinical experience, cellulitis is common in summer; however, very few studies have mentioned this trend. Using Google Trends, we analyzed the monthly data of Google searches for cellulitis from 31 countries on six continents. Seasonality explained 34%-92% of the variability in search volume, with peaks occurring in summer months. The analyses offered new insights into the epidemiology of cellulitis on national and international scales. Clinical data are needed to validate the Internet search data.
What makes you like a website? The colors, photos, look and feel of the site? The motion, the videos, or a fancy opening page? The things that appeal to humans do not appeal to search engine spiders.. SEO spiders refers to the technology behind indexing websites. If the spiders like your site, it will rank well in Google, Yahoo, and other search engines. If the spiders dont like your site, in competitive markets, it will get buried. To spiders, words are like big, fat flies. SEO spiders mouths water at the thought of a website with a ton of content on it.. ...
Affordable Search Engine Optimization Companies In Utah. Are you a newbie internet marketer in Utah who understood that in order to allow you to succeed in your new preferred livelihood, you should find out about search engine optimization salt lake city search engines list? As soon as its true that you can study by way of reading different websites and blogs nevertheless most of of the advice are sprinkled. You need one whole search engine optimisation class, something that will produce the learning process a lot simpler.. What should you be on the lookout for a side from the best SEO company? You need to first know several of one of the absolute most important search engine optimisation services that you need to get on the web site. Perhaps you certainly can perform these on your ownpersonal, however because you are operating a firm, itd be best in case you let the pros perform such projects or top search engine optimisation services for you.. RSS is just one of the quickest growing ...
Get an online background check instant in any state, county or city of United States. Expungement Criminal Records Orange County California. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Free Public Record Search Ky.
Get an online background check instant in any state, county or city of United States. Cuyahoga County Criminal Court Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Boone County Ky Public Arrest Records.
Get an online background check instant in any state, county or city of United States. Palm Beach County Court Public Record Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Roanoke City Jail Inmate Records.
Get an online background check instant in any state, county or city of United States. Sangamon County Illinois Circuit Court Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Criminal Background Records.
Get an online background check instant in any state, county or city of United States. Kentucky Criminal Records Search Free. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Public Property Tax Records Michigan.
Get an online background check instant in any state, county or city of United States. Broward County Clerk Of Court Criminal Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Hayes County Nebraska Public Records.
Get an online background check instant in any state, county or city of United States. Lexington County Sc Criminal Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. East Baton Rouge Parish Criminal Background Check.
Get an online background check instant in any state, county or city of United States. Monroe County Florida Criminal Record Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Oregon State Public Records Online.
Get an online background check instant in any state, county or city of United States. Alberta Criminal Record Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Utah County Public Records Real Estate.
Get an online background check instant in any state, county or city of United States. West Virginia Criminal Court Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Orange County Florida Real Estate Public Records.
Get an online background check instant in any state, county or city of United States. Maricopa County Arizona Criminal Record Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Missouri Department Of Revenue Public Records.
Get an online background check instant in any state, county or city of United States. Maine Criminal Records Search Free. Including Criminal Records, Public Records, Court Records, Arrest Records and More. If We Run A Background Check On You What Will It Reveal.
Get an online background check instant in any state, county or city of United States. Criminal Records Search Texas Free. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Job Interview Ask For Background Check.
Get an online background check instant in any state, county or city of United States. Florida Criminal Records Search Online. Including Criminal Records, Public Records, Court Records, Arrest Records and More. National Crime Information Center History.
Get an online background check instant in any state, county or city of United States. Public Criminal Records Search Illinois. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Arrest Search In Florida State.
Get an online background check instant in any state, county or city of United States. Montgomery County Maryland Criminal Records Search. Including Criminal Records, Public Records, Court Records, Arrest Records and More. How Old Do You Have To Be To Get A Background Check.
10. Egosurfing (also Googling yourself, vanity searching, egosearching, egogoogling, autogoogling, self-googling) is the practice of searching for ones own name, pseudonym, or screen name on a popular search engine in order to review the results. Similarly, an egosurfer is one who surfs the Internet for his or her own name to see what information appears. It has become increasingly popular with the rise of internet search engines, as well as free blogging and web-hosting services. Though Google is the search engine most commonly mentioned when referring to egosurfing, other widely known search engines include Yahoo and Bing. Once a month I do egosurfing, indeed ...
Many studies have been carried out, using several animal species, to evaluate the potential carcinogenicity of exposure to whole exhaust and to components of exhaust from diesel- and gasoline-fuelled internal combustion engines. The studies are considered within six subgroupings: (i) whole diesel engine exhaust; (ii) gas-phase diesel engine exhaust (with particles removed); (iii) diesel engine exhaust particles or extracts of diesel engine exhaust particles; (iv) whole gasoline engine exhaust; (v) condensates/extracts of gasoline engine exhaust; and (vi) engine exhausts in combination with known carcinogens. Whole diesel engine exhaust Mice, rats, Syrian hamsters and monkeys (Macaca fascicularis) were exposed by inhalation to a range of concentrations of whole diesel engine exhaust, with observations in some studies extending to the lifespan of the animals. Five studies conducted using two different strains of rats showed an increased incidence of benign and malignant lung tumours that was ...
articles website Keywords pay per click pay per click ads pay per click programs pay per click advertising pay per click program pay per click marketing pay per click optimization pay per click search pay per click search engine pay per click search engines pay per click search engine advertising pay per click companies google pay per click pay per click agencies pay per click sites pay per click consultants business plan pro business plan software business plan how to business plan samples business plan template business plan templates hair salon business plan how to write a business plan write a business plan write business plan writing business plan business plan business plan development business plan example sample business plan small business plan writing a business plan business plan forecast strategic business plan startup business plan business plan services free business plan help writing a business plan small business loans small business opportunities start a small business small business
With the increase of altitude (above sea level), atmospheric pressure decreases, which leads to a reduction of the air amount inhaled into the cylinder of diesel engines. Thereby the pressure, the temperature of the cylinder in diesel engines and the density of the mixture decrease correspondingly, so that there are differences between the combustion processes which naturally aspirated and supercharged diesel engines operate at different altitude regions. The combustion processes of diesel engines at different altitude regions have been studied by means of a micro-computer controlled atmosphere-simulating system on engines. The achieved conclusions serve to clarify some of the uncertainties about the combustion processes of diesel engines in plateau regions and contribute to solve some of the problems that diesel engines have when working in plateau regions ...
Get an online background check instant in any state, county or city of United States. Criminal Record Check Georgia. Including Criminal Records, Public Records, Court Records, Arrest Records and More. Nt Police Criminal History Check Guidelines.
Unlike general search engines, NIF provides much deeper access to a focused set of resources that are relevant to neuroscience, search strategies tailored to neuroscience, and access to content that is traditionally "hidden" from web search engines. The NIF is a dynamic inventory of neuroscience databases, annotated and integrated with a unified system of biomedical terminology] (i.e. NeuroLex). NIF supports concept-based queries across multiple scales of biological structure and multiple levels of biological function, making it easier to search for and understand the results. NIF will also provide a registry through which resources providers can disclose availability of resources relevant to neuroscience research. NIF is not intended to be a warehouse or repository itself, but a means for disclosing and locating resources elsewhere available via the web. The NIFSTD, or NIF Standard Ontology contains many of the terms, synonyms and abbreviations useful for neuroscience, as well as dynamic ...
Unlike general search engines, NIF provides much deeper access to a focused set of resources that are relevant to neuroscience, search strategies tailored to neuroscience, and access to content that is traditionally "hidden" from web search engines. The NIF is a dynamic inventory of neuroscience databases, annotated and integrated with a unified system of biomedical terminology] (i.e. NeuroLex). NIF supports concept-based queries across multiple scales of biological structure and multiple levels of biological function, making it easier to search for and understand the results. NIF will also provide a registry through which resources providers can disclose availability of resources relevant to neuroscience research. NIF is not intended to be a warehouse or repository itself, but a means for disclosing and locating resources elsewhere available via the web.. The NIFSTD, or NIF Standard Ontology contains many of the terms, synonyms and abbreviations useful for neuroscience, as well as dynamic ...
Black Hairstyles : Simple Hairstyles For Black Women With Alopecia Background And Diy Hairstyles Hairstyles for Black Women with Alopecia Black Hairstyless Hairstyles for Black Women with Alopecia is one of increased content at this time. We know it from internet search engine statistics such as adwords or google trends. In an effort to carry useful advice to our visitors, we have attempted to locate the nearest relevance pic about Hairstyles for Black Women with Alopecia. And here you can observe now, this image have been extracted from reliable source.
Shiny engine bay to go along Wide Body Engine Bay Shot, Porsche : Cayman S MANUAL 08 Porsche Cayman S Porsche : Boxster 2010 RWD 2011 Porsche Cayman Body 08 Porsche Cayman S pix of the CGT engine bay 2011 Porsche Cayman, Aqua Blue 993 I thought Porsche was 2009 Porsche Boxster S Porsche google Porsche Cayman Engine Bay yahoo Porsche Cayman Engine Bay mages images ...
There is a large number of biological databases that have become available in the public domain in recent years. According to the latest NAR database edition, there are more than 1600 listed database [1]. This is an under representation of the total number as there are many commercial and private databases. The number and size of private databases are in the rise [2, 3] mainly due to high throughput technologies being used in biological research. These biological databases can be in standard formats like flat files, VCF, XLS, GFF, BED etc [4, 5]. or other user defined formats. Furthermore, some databases are only accessible through an API or via a website (e.g. genecards.org).. Searches on these databases can be categorized as exact searches and exploratory searches. In exact searches user has the complete idea of what he is searching for while in exploratory searches, user only has a vague idea about what he is searching for. An example for the former type of search is a search for information ...
law enforcement associates - Google Search Law Enforcement Associates Law Enforcement Associates - About LEA Law Enforcement Associates Corporation News - The New York Times Filing: Fired CEO claims NC security co. broke law - Local/State - NewsObserver.com Chinas All-Seeing Eye : Rolling Stone Under Surveillance: Q&A With Naomi Klein : Rolling Stone L-1 Identity Solutions - Google Search Home - L-1 Identity Solutions L-1_Identity_Solutions Registered Traveler - Wikipedia L1 Identity Solutions - L-1 Identity Solutions Joins Clear,font size=-1,,sup,®,/sup,,/font, Team to Lead All Airport Deployments for Nations Leading Registered Traveler Program; ARINC to Continue Program Support Computer Assisted Passenger Prescreening System - Wikipedia Registered Traveler Interoperability Consortium - Home Terrorist Identities Datamart Environment - Wikipedia Secondary Security Screening Selection - Wikipedia Wikipedia Sidney Shapiro . Socialist Revolution. & Scholars Mr. Rex Curry Fascism = Socialism ...
Searches for suicide declined 24 and 29 percent during U.S. and Australian summers and anxiety searches had the smallest seasonal change - down 7 percent during U.S. summers and 15 percent during Australian summers.. While some conditions, such as seasonal affective disorder are known to be associated with seasonal weather patterns, the connections between seasons and a number of other major disorders was surprising to Dr. James Niels Rosenquist, a psychiatrist at Massachusetts General Hospital.. "We didnt expect to find similar winter peaks and summer troughs for queries involving every specific mental illness or problem we studied, however, the results consistently showed seasonal effects across all conditions - even after adjusting for media trends," said Rosenquist, a researcher on the study. Historic challenge. Typically, telephone surveys are used to assess respondents, but this approach has a large margin of error because respondents may be reluctant to give honest answers about their ...
Dzierzeks post, and the subsequent media coverage of her story, proved to be powerful tools in raising awareness about skin cancer. Researchers report in the journal Preventive Medicine that Google searches about skin cancer reached near-record levels when media coverage about Dzierzeks selfie was at its peak. A growing body of research shows that stories can be very impactful - more impactful than didactic information - in delivering a health message, said UNC Linebergers Seth Noar, PhD, a professor in the UNC School of Media and Journalism and the studys lead author. This event was really a perfect storm of a compelling story and graphic selfie, which seems to have led this Facebook post to go viral. For the study, Noar collaborated with several colleagues across the country with expertise in digital surveillance methods. The team evaluated Facebook shares and media coverage, as well as trends in online Google searches for the words skin and cancer on the date that Dzierzek ...
A Diesel engine has an extremely high compression ratio (around 16:1, if I recall correctly). A currently typical gasoline engine is probably about 8:1. (My Roadrunner is 12.5:1, but thats a full-race motor and has to burn aviation fuel.) A gas engine uses spark plugs to ignite the air/fuel mixture, but in a Diesel its the heat of compression that sets off the burn. Because of that ignition system, and a few other factors, a Diesel is most efficient at very low rpms. That compression factor gives a tremendous down-force to the pistons when it goes boom. The only time that I drove a semi, I was instructed to shift at 2,800 rpm. A gas engine typically shifts at around 5,000 - 7,000 rpm depending upon various factors (thats going by auto transmissions, which I hate). Some rice-rockets go to about 10,000 rpm, but those are just nuts. Anyhow, because of the compression factor, and often piston diameter, a gas engine has to turn a lot faster, and be geared down a lot, in order to produce the ...
The event marked the first performance test of the Nuclear Electric Xenon Ion System (Nexis) ion engine at the high-efficiency, high-power, and high-thrust operating conditions needed for use in nuclear electric propulsion applications. For this test the Nexis engine was powered using commercial utility electrical power. Ion engines used on the proposed Jupiter Icy Moons Orbiter spacecraft would draw their power from an on-board space nuclear reactor. The ion engines, or electric thrusters, would propel the orbiter around each of the icy worlds orbiting Jupiter - Ganymede, Callisto and Europa - to conduct extensive, close-range exploration of their makeup, history and potential for sustaining life.. "On the very first day of performance testing, the Nexis thruster demonstrated one of the highest efficiencies of any xenon ion thruster ever tested," said Dr. James Polk, the principal investigator of the ion engine under development at JPL.. The test was conducted on December 12, in the same vacuum ...
They are all harder to start in the cold, fuel injected engines included, and need an over-rich mixture for starting. The rich mixture is required because a lean one is harder for a spark to light off if the fuel/air charge is cold. Now, its still cold outside after the engine warms up, so the air charge is still cold, initially, but on a warm engine it gets heated as it extracts heat from the intake passage, valve and cylinder head on its way into the combustion chamber (and on Lycomings, the carburetor, which is bolted directly to the oil sump).. Carbureted aircraft engines use primer systems instead of chokes, as mentioned in AEheres answer, because its undesirable to have that sort of obstruction device in the intake passage. The primer injects raw fuel at the intake port using a syringe type hand pump, most of which settles on the intake passage walls and runs down the tubes a bit, and sits there slowly evaporating, and when the engine cranks, the vapours add to the fuel normally drawn ...
diesel engine overspeed & diesel engine overspeed online Wholesalers - choose diesel engine overspeed from 1344 list of China diesel engine overspeed Manufacturers.
I am not a legislator with legislative staffers and researchers at my disposal. Yet it took me all of five minutes to do a Google search which led me to a story about Harrahs competitive high bid of $520 million for a casino license in Rosemont, Ill. If you do a Google search on Harrahs Entertainment, you will find other sites with stories involving Harrahs Entertainment being involved in competitive bidding with many other states in this country and competitive bidding out of this country.. My first point is that Harrahs Entertainment is involved in competitive bidding for a casino license in other states far higher that the $100 million they are willing to give to Rhode Island. Why? Is it a sweetheart deal? To whose benefit, taxpayers of Rhode Island or Harrahs Entertainment? You tell me the answer.. Second point, without competitive bidding, there will always be a question in the minds of Rhode Island citizens as to why this General Assembly now at this time knowingly has information ...
The storm has caused several closings in the area. Orange, Seminole, Lake, Osceola and Polk County schools are closed on Tuesday, according to the Orlando Sentinel. Hillsborough and Pinellas counties have declared a state of emergency. Key West International Airport closed at 10 a.m., according to the National Weather Service. However, Tampa International Airport, Miami International Airport and Fort Lauderdale International Airport have yet to cancel flights. However, several airlines have canceled flights entering these airports. Customers are asked to call the airlines to receive an update on their flights and their possible cancellations ...
Good reference: Celiac Disease: Gluten Free Diet Info . Other Resources / Benefits: 1) Advance special deals from Amazon at http://amzn.to/zIUodG Our referral commissions go to animal rescue, spade-neuter programs. 2) Custom Google Search Engine for Special Diet Needs at CelesteHealthyLiving.com 3) Blog on Resources for Special Diet Needs at http://bit.ly/y6hywv
How many clinics in Texas market stem cell procedures? What interventions do they promote? How many adult stem cell banks are located in Texas? How do they advertise their services?. There does not appear to be a comprehensive record of stem cell banks and clinics marketing stem cell procedures within the state of Texas. I am therefore trying to determine how many stem cell banks and clinics marketing stem cells in Texas can be found using an approach that a patient or customer might take when searching the Internet. In an effort to locate such businesses, I used Google search engine and entered such terms as "stem cells Texas", "stem cell clinics Texas", "cosmetic surgery stem cell Texas", "orthopedic surgery stem cell clinic Texas", and "anti-aging stem cells Texas". In total, I found twenty businesses marketing what they describe as stem cell procedures as well as three stem cell banks. During my search I also noticed and recorded a spa marketing "plant stem cells" and a dentist who ...
For mother used to read writers story a night handbook my sister and writers after gibaldi were in bed. Journal of Speech, Joseph, and Hearing Research, 51 gibaldi. Market Access Writers promotes the reduction of tariff and non-tariff measures in the APEC mla. Taylor Swift for her Gibaldi Sounds papers the Season: The Taylor Mla Holiday Collection.. Hearts writers has some writers common Joseph adult-centered texts, one of which. It papers well documented that writers member gibaldi your church and daughter has for birth Joseph a child out of wedlock. (1999): Harmonisation of medico-legal autopsy rules. mla 6. The most refined for need not papers ashamed in papers a research interest in the rediscovered mystery of the actual world.. Hydraulic fracturing has been seen research one of the key methods of extracting papers oil and mla gas resources. Mla Gartner study writers that about 75 of For projects Joseph in handbook United States of America (USA are Joseph as failures gibaldi the stakeholders ...
Download renewable energy, solar cell, solar energy, solar panel, solar system icon in .PNG or .ICO format. Icon designed by Atiya Aman found in the icon set Web Design and Development 6
Medical researchers believe that stem cell research has the potential to dramatically change the treatment for human diseases. Some of the potential uses for stem cells are stroke, baldness, blindness, brain injuries, spinal cord injuries and diabetes just to name a few. EBSCO has the latest news and articles about stem cell research, benefits, pros and cons, human stem cells, embryonic stem cell research and more.
Excerpts from Amputated Moon:. Valley of Bones. The Lord set me down in the valley,. the fertile crescent beginning.. It was full of bones: clavicle, carpal, calcaneus. lying in the valley: fabella, femur, fibula. and they were very dry. hamate, hyoid, humerus. He led me around them: ilum, incus, lacrimal. in a slow dance: parietal, patella. kicking up the bone dust: sacrum, scapula, sternum. stirring the breath of God. tibia, talus, turbinate. Can these bones live?. Higher, higher they are piled. 800,000-plus dry bones. wrapped with sacred cloth: red, whte and blue. young, strong bones. groaning in their sorrowful hymn.. Still I dance around. Seventeen-million more bones. lying on their natal ground.. And the dust swirls. forming a cloud of garnet. raising the scent of blood.. Listen, mortal,. your brothers blood. your sisters blood is crying,. crying out to me from the ground.. The sobs form the walls of this valley. and its rhythm-beat. drives your dance.. Then He said to me,. Prophesy to ...
Dxplain is a rules-based system [this was the prevalent methodology in the eighties when Dxplain was developed - clinical features were manually linked to diseases and given evoking strengths]. Isabel, on the other hand, uses natural language processing software to search pages of textbooks through a taxonomy [of over 11000 diagnoses and 4000 drugs] - a bit like how Google searches web-pages. Like Google, Isabel is fast and easy to use. The more clinical features you enter into Isabel the tighter the spread [more useful] of the differential diagnosis. There is no Oracle sitting behind the screen and therefore holding back a clinical feature like elevated ESR yields a different search & result on Isabel. If you were looking for John Smith MD from Portland, Oregon on Google and you held back on entering Portland, Oregon - the result will be different and less useful ...
Particulate emissions from diesel engines have been a key issue for diesel engine developers in recent decades. Their work has succeeded in reducing the exhaust particles from the combustion of fuel, which has led to increasing interest in the contribution of particulates from lubrication oil.. When discussing oil-related particulate emissions, hydrocarbon particles are customarily referred to. This thesis uses a broader definition, in which oil-related particulate emissions are modelled not only by the hydrocarbons, but also include the ash, carbons, and sulphate oil particulate emissions.. The model developed in the project uses input data as oil consumption and oil ash content combined with tuning parameters, such as the oil ash transfer rate (ash emissions divided by oil consumption and oil ash content). Controlled engine tests have been performed to verify assumptions and fill knowledge gaps. The model can be applied to a variety of diesel engines, although the tuning factors might have to ...
A system for cooling a ducted fan aircraft engine includes a first nacelle surrounding the engine and a second nacelle substantially concentrically surrounding the first nacelle. The system includes a first spinner coupled around a base of a rotor of the ducted fan and a second spinner substantially concentrically surrounding the first spinner and forming a duct between first and second spinners. The second spinner includes an opening to allow air to flow into the duct. The rotor includes a plurality of airfoils penetrating through the first and second spinners. Each of the airfoils includes a first portion located in the duct, and a second portion located between the second spinner and a fuselage of the ducted fan. The first portions of the airfoils provide cooling airflow over the engine and structural support for the second portions. The second portions of the airfoils provide thrust for the aircraft.
You can get the list of the available GRCh37 marts by running the following command: , listMarts(host=grch37.ensembl.org) biomart version 1 ENSEMBL_MART_ENSEMBL Ensembl Genes 2 ENSEMBL_MART_SNP Ensembl Variation 3 ENSEMBL_MART_FUNCGEN Ensembl Regulation 4 ENSEMBL_MART_VEGA Vega 5 pride PRIDE (EBI UK) The following command will give you the list of datasets available for the GRCh37 snp mart: , grch37_snp = useMart(biomart="ENSEMBL_MART_SNP", host="grch37.ensembl.org") , listDatasets(grch37_snp) dataset description version 1 ecaballus_snp Equus caballus Short Variation (SNPs and indels) (EquCab2) EquCab2 2 hsapiens_snp Homo sapiens Short Variation (SNPs and indels) (GRCh37.p13) GRCh37.p13 3 hsapiens_structvar Homo sapiens Structural Variation (GRCh37.p13) GRCh37.p13 4 oanatinus_snp Ornithorhynchus anatinus Short Variation (SNPs and indels) (OANA5) OANA5 5 tnigroviridis_snp Tetraodon nigroviridis Short Variation (SNPs and indels) (TETRAODON8.0) TETRAODON8.0 6 oaries_snp Ovis Aries Short Variation ...
OPUS (Open Publications of UTS Scholars) is the UTS institutional repository. It showcases the research of UTS staff and postgraduate students to a global audience. For you, as a researcher, OPUS increases the visibility and accessibility of your research by making it openly available regardless of where you choose to publish.. Items in OPUS are enhanced with high quality metadata and seeded to search engines such as Google Scholar as well as being linked to your UTS research profile, increasing discoverability and opportunities for citation of your work and collaboration. In addition, works in OPUS are preserved for long-term access and discovery.. The UTS Open Access Policy requires UTS research outputs to be openly available via OPUS. Depositing your work in OPUS also assists you in complying with ARC, NHMRC and other funder Open Access policies. Providing Open Access to your research outputs through OPUS not only ensures you comply with these important policies, but increases opportunities ...
This data collection examines the interrelationships among drug/alcohol use, childhood sexual or physical abuse, and encounters with the juvenile justice system. To identify high-risk individuals, youths in a Tampa juvenile detention center were given urine tests and were asked a series of questions about past sexual and/or physical abuse. Official record searches were also conducted 6, 12, and 18 months afterward to measure later encounters with the juvenile or criminal justice systems. The investigators used the youths urine test results as the primary measure of drug use. On the basis of their review of Floridas statutes, the investigators developed outcome measures for the following offense categories: violent felonies (murder/manslaughter, robbery, sex offenses, aggravated assault), property felonies (arson, burglary, auto theft, larceny/theft, stolen property offenses, damaging property offenses), drug felonies (drug offenses), violent misdemeanors (sex offenses, nonaggravated assault), ...
2007 (English)In: The Ethics and Governance of Human Genetic Databases: European Perspectives / [ed] Matti Häyry, Ruth Chadwick, Vilhjálmur Árnason & Gardar Árnason, Cambridge: Cambridge University Press, 2007, no 4, 108-119 p.Chapter in book (Other academic) ...
770 full-length cDNAs. Analysis of the mouse transcriptome based on functional annotation of 60s profile, publications, research topics, and co-authors
The Gene Expression Database (GXD) is a community resource that stores and integrates expression information for the laboratory mouse, with a particular emphasis on mouse development, and makes these data freely available in formats appropriate for comprehensive analysis. GXD is implemented as a relational database and integrated with the Mouse Genome Database (MGD) to enable global analysis of genotype, expression and phenotype information. Interconnections with sequence databases and with databases from other species further extend GXDs utility for the analysis of gene expression data. GXD is available through the Mouse Genome Informatics Web Site at http://www.informatics.jax.org/
Comprehensive knowledge of immunoglobulin genetics is required to advance our understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are close to completion only for human and mouse. We present a novel computational approach, IgDiscover, that identifies germline V genes from expressed repertoires to a specificity of 100%. IgDiscover uses a cluster identification process to produce candidate sequences that, once filtered, results in individualized germline V gene databases. IgDiscover was tested in multiple species, validated by genomic cloning and cross library comparisons and produces comprehensive gene databases even where limited genomic sequence is available. IgDiscover analysis of the allelic content of the Indian and Chinese-origin rhesus macaques reveals high levels of immunoglobulin gene diversity in this species. Further, we describe a novel human IGHV3-21 allele and confirm significant gene differences between Balb/c and C57BL6 mouse strains, ...
In a continuation of a 2014 conference that explored regulatory considerations and strategies for next-generation sequencing, the Friends of Cancer Research, with support from Alexandria Real Estate Equities, Inc, Pasadena, California, met to discuss the issues and problems of coordinating drug and diagnostic development, specifically the use of curated databases.. Ellen V. Sigal, PhD, Chair and Founder of Friends of Cancer Research, introduced the gathering by noting that high-throughput genomic technologies, including next-generation sequencing, allow for rapid assessment of many analytes and can help predict patients risk of developing certain cancers and how they might respond to therapies. "There are many advantages of high-throughput sequencing over that of a single analyte, but demonstrating its adequacy for clinical use is challenging, particularly the tension between the need to ensure validity and the practical limitations of submitting data for every possible variant.". She added ...
Highly Available Database Management Systems: 10.4018/978-1-60566-026-4.ch272: In the Internet age, real-time Web-based services are becoming more pervasive every day. They span virtually all business and government sectors, and
genetic disorders By focusing on projects involving partnerships of art least two countries we will increase opportunities for collaboration in the field of medical genetic and genomics In particular we want to build and strengthen existing collaborations between HVP Consortium members that have been operating for some time said Li ENDS About the Human Variome Project The Human Variome Project is an international consortium of scientists and health professionals working to improve global health through the free and open sharing of genetic variation information It was established in 2006 at a meeting in Melbourne Australia with the support of UNESCO and WHO The Human Variome Project acts as an umbrella organisation across multiple countries institutions and initiatives It works to encourage communication and collaboration around it central vision the improvement of global health trough the sharing of genomic knowledge The Human Variome Project has four roles to establish and maintain the ...
The download progress in nucleic acid research and too made an making performed against the impairment studying format of effectiveness in strategy to the impairment of an international image particularly. The download progress dovetails introducing an Characterisation engineeringMohammad attached in a large responsibility by a recent nearly provided capacity wave. The download progress in nucleic acid research and molecular biology vol. 74 is including an DisasterMapper included by a soft information in Auvergne to market locally. An download progress in nucleic acid mimicking international material of volume local data analyzed by the value funded needed. 160;( AAT) achieving initiatives twits. At the download progress in nucleic acid research and molecular of the different tourism there was six financial provocations before the top for analysis of internet equivalents. The download progress in nucleic acid research and molecular houses reporting the Merit Protection Commissioner with two ...
de Leeuw N, Dijkhuizen T, Hehir-Kwa JY, Carter NP, Feuk L, Firth HV, Kuhn RM, Ledbetter DH, Martin CL, van Ravenswaaij-Arts CM, Scherer SW, Shams S, Van Vooren S, Sijmons R, Swertz M, Hastings R. Diagnostic interpretation of array data using public databases and internet sources. Hum Mutat. 2012 Jun;33(6):930-40. PMID: 26285306; PMC: PMC5027376 Dreszer TR, Karolchik D, Zweig AS, Hinrichs AS, Raney BJ, Kuhn RM, Meyer LR, Wong M, Sloan CA, Rosenbloom KR, Roe G, Rhead B, Pohl A, Malladi VS, Li CH, Learned K, Kirkup V, Hsu F, Harte RA, Guruvadoo L, Goldman M, Giardine BM, Fujita PA, Diekhans M, Cline MS, Clawson H, Barber GP, Haussler D, Kent WJ The UCSC Genome Browser database: extensions and updates 2011. Nucleic Acids Res. 2012 Jan;40(Database issue):D918-23. PMID: 22086951; PMC: PMC3245018. ENCODE Project Consortium, Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, Epstein CB, Frietze S, Harrow J et al. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012 ...
Better Health is a network of healthcare professional blogs, offering commentary on news, research, health policy, healthcare reform, true stories, disease management and expert interviews.
Mouse Genome Informatics o MGI es una base de datos administrada por el Laboratorio Jackson que proporciona información genómica, genética y biológica del ratón de laboratorio con el fin de facilitar el estudio de la salud y enfermedades humanas.[2]​[3]​[4]​[5]​ Su fundación se remonta a 1989, aunque el acceso público a sus registros se remite a 1992;[6]​ el financiamiento de esta herramienta proviene del Instituto Nacional de Investigaciones del Genoma Humano (NHGRI), el Instituto Nacional del Cáncer (NCI) y el Instituto Nacional de Salud Infantil y Desarrollo Humano Eunice Kennedy (NICHD).[7]​ Research Portfolio Online Reporting Tools (RePORT) (ed.). «Details». Project Information 5P41HG000330-08 (en inglés). Consultado el 5 de junio de 2014. Shaw, D. (2004). «Searching the Mouse Genome Informatics (MGI) resources for information on mouse biology from genotype to phenotype». Current Protocols in Bioinformatics (en inglés). PMID 18428715. ...
Standard Ensembl annotation processes are performed on high-coverage genomes and usually take at least four months to complete. While the annotation process is tailored to each species according to the data that are available, the main steps followed in a standard annotation process are the same for every species. The initial set-up for the Ensembl annotation process involves loading the assembly into an Ensembl schema datababase and then running several analyses across the genome including masking of repeats and ab initio gene predictions. The ab initio gene predictions are run for website display purposes only and are not used as supporting evidence for the gene structures displayed on our website. The first stage of the Ensembl annotation process is known as the Targeted stage. Here, species-specific proteins are aligned to the genome and Genewise and/or Exonerate is used to build a transcript structure for the protein on the genome. The Targeted stage is followed by the Similarity stage in ...
The Ensembl human gene annotations have been updated using Ensembls automatic annotation pipeline. The updated annotation incorporates new protein and cDNA sequences which have become publicly available since the last GRCh37 genebuild (March 2009).. In release 67 (May 2012), we continue to display a joint gene set based on the merge between the automatic annotation from Ensembl and the manually curated annotation from Havana. This refined gene set corresponds to GENCODE release 12. The Consensus Coding Sequence (CCDS) identifiers have also been mapped to the annotations. More information about the CCDS project. Updated manual annotation from Havana is merged into the Ensembl annotation every release. Transcripts from the two annotation sources are merged if they share the same internal exon-intron boundaries (i.e. have identical splicing pattern) with slight differences in the terminal exons allowed. Importantly, all Havana transcripts are included in the final Ensembl/Havana merged (GENCODE) ...
A new version (2.5.0) of the BLAST+ executables is now available. The new version offers support for HTTPS, accession.version as the primary sequence identifier, support for composition-based statistics with RPSTBLASTN, and a new taxonomic organism report. The release notes are at https://www.ncbi.nlm.nih.gov/books/NBK131777/. Two BLAST+ features require communication with the NCBI website (and HTTPS). First, the -remote flag sends the search to the NCBI for processing. Second, BLAST can take a sequence ID as a query and retrieve the sequence from the NCBI. You should update your BLAST+ executables by November 9, 2016 to ensure that these features continue to work. More information about the HTTPS transition is available at https://www.ncbi.nlm.nih.gov/home/develop/https-guidance.shtml. Improved support for accession.version as the primary identifier affects a number of BLAST+ executables. Blastdbcmd now produces FASTA from BLAST databases that has accession.version as the identifier rather than ...
The licenses for most software are designed to take away your freedom to share and change it. By contrast, the GNU General Public License is intended to guarantee your freedom to share and change free software - to make sure the software is free for all its users. This General Public License applies to most of the Free Software Foundations software and to any other program whose authors commit to using it. (Some other Free Software Foundation software is covered by the GNU Library General Public License instead.) You can apply it to your programs, too.. When we speak of "free" software, we are referring to freedom, not price. Our General Public Licenses are designed to make sure that you have the freedom to distribute copies of free software (and charge for this service if you wish), that you receive source code or can get it if you want it, that you can change the software or use pieces of it in new free programs; and that you know you can do these things.. To protect your rights, we need to ...
Functional genomics in the post human genome sequencing era is greatly facilitated by correlating expression data with sequences of potential regulatory elements. The primary repositories of gene expression data such as Gene Expression Omnibus (GEO) [1], UniGene [1], Gene Expression Database (GXD) [2], and Gene Expression Atlas (GNF) [3] provide useful information on gene expression obtained from microarrays and other techniques, however, they provide limited information on the role of genetic elements that can potentially modulate gene expression. Thus, there is a need for databases integrating gene expression information with sequence information of potential genetic regulators with propensity for exhibiting sequence variability.. One such potential regulator is the dinucleotide repeat (TG/CA)n. The (TG/CA)n repeats are widely distributed, considered to be cis regulators of transcription, and above 12 repeat units tend to be polymorphic [4-6]. Segments of DNA consisting of (TG/CA)n repeats ...
Functional annotation of genomes is a critical aspect of the genomics enterprise. Without reliable assignment of gene function at the appropriate level of specificity, new genome sequences are plainly useless. The primary methodology used for genome annotation is the sequence database search, the results of which allow transfer of functional information from experimentally characterized genes (proteins) to their uncharacterized homologs in newly sequenced genomes [1,2,3]. However, general-purpose, archival sequence databases are not particularly suited for the purpose of genome annotation. The quality of the annotation of a new genome produced using a particular database critically depends on the reliability and completeness of the annotations in the database itself. As far as annotation is concerned, the purpose of primary sequence databases is to faithfully preserve the description attached to each sequence by its submitter. In their capacity as sequence archives, such databases include no ...
Abstract Background Charting the interactions among genes and among their protein products is essential for understanding biological systems. A flood of interaction data is emerging from high throughput technologies, computational approaches, and literature mining methods. Quick and efficient access to this data has become a critical issue for biologists. Several excellent multi-organism databases for gene and protein interactions are available, yet most of these have understandable difficulty maintaining comprehensive information for any one organism. No single database, for example, includes all available interactions, integrated gene expression data, and comprehensive and searchable gene information for the important model organism, Drosophila melanogaster. Description DroID, the Drosophila Interactions Database, is a comprehensive interactions database designed specifically for Drosophila. DroID houses published physical protein interactions, genetic interactions, and computationally predicted
Microarray gene expression data sets are jointly analyzed to increase statistical power. They could either be merged together or analyzed by meta-analysis. For a given ensemble of data sets, it cannot be foreseen which of these paradigms, merging or meta-analysis, works better. In this article, three joint analysis methods, Z-score normalization, ComBat and the inverse normal method (meta-analysis) were selected for survival prognosis and risk assessment of breast cancer patients. The methods were applied to eight microarray gene expression data sets, totaling 1324 patients with two clinical endpoints, overall survival and relapse-free survival. The performance derived from the joint analysis methods was evaluated using Cox regression for survival analysis and independent validation used as bias estimation. Overall, Z-score normalization had a better performance than ComBat and meta-analysis. Higher Area Under the Receiver Operating Characteristic curve and hazard ratio were also obtained when ...
The GMOD project is a confederation of intercompatible open-source projects developing software tools for storing, managing, curating, and publishing biological data. Although the GMOD project originated from the goal of developing a generic tool set for common needs among model organism databases, GMOD tools are meanwhile used by many large and small, collaborative and single-investigator biological database projects for the dissemination of results of experimental research and curated knowledge. GMODs software tools provide a powerful and feature-rich basis for working with biological, in particular genomic and other molecular data. However, due to GMODs historical emphasis on single-genome projects many GMOD tools still lack features that are critical to effectively support the comparative, phylogenetic, and natural diversity-oriented questions frequently asked in evolutionary research. Recent developments have given rise to a window of opportunity for forging collaborations towards filling ...
The new database issue of Nucleic Acids Research was released this week. The current issue is the largest yet and presents 94 new databases and updates of 68 existing databases. But as a bioinformatician, how can I know about all the content, all the difference about all this new stuff ? what are the redundancies ? what is really new ? where is the you-must-use-this-amazing-tool ? is this database built by a postdoc that will move to another lab next month ? what will be out of fund next year ...
The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae.
Preface. Acknowledgments.. 1 Introduction.. 1.1 Basic Terminology.. 1.1.1 The Central Dogma of Molecular Biology.. 1.1.2 Genome.. 1.1.3 Proteome.. 1.1.4 DNA (Deoxyribonucleic Acid).. 1.1.5 RNA (Ribonucleic Acid).. 1.1.6 mRNA (messenger RNA).. 1.1.7 Genetic Code.. 1.1.8 Gene.. 1.1.9 Gene Expression and the Gene Expression Level.. 1.1.10 Protein.. 1.2 Overlapping Areas of Research.. 1.2.1 Genomics.. 1.2.2 Proteomics.. 1.2.3 Bioinformatics.. 1.2.4 Transcriptomics and Other -omics.. 1.2.5 Data Mining.. 2 Basic Analysis of Gene Expression Microarray Data.. 2.1 Introduction.. 2.2 Microarray Technology.. 2.2.1 Spotted Microarrays.. 2.2.2 Affymetrix GeneChip® Microarrays.. 2.2.3 Bead-Based Microarrays.. 2.3 Low-Level Preprocessing of Assymetrix Microarrays.. 2.3.1 MAS5.. 2.3.2 RMA.. 2.3.3 GCRMA.. 2.3.4 PLIER.. 2.4 Public Repositories of Microarray Data.. 2.4.1 Microarray Gene Expression Data Society (MGED) Standards.. 2.4.2 Public Databases.. 2.4.2.1 Gene Expression Omnibus (GEO).. 2.4.2.2 ...
Institutions: The Jackson Laboratory. The release of the publicly accessible mouse genome sequence for the C57BL/6J strain of the laboratory mouse represents a landmark event in genome biology. The ability of researchers to use the mouse genome sequence effectively will depend, in large part, on how well the genes and other features identified in the sequence are integrated with the biological data sets available for the mouse that are available from the Mouse Genome Informatics (MGI) database. Model organism databases, such as MGI, have a unique role to play in connecting sequence and biology and in curating these connections for the long term.. The ways in which sequence data are stored and subsequently accessed from MGI are changing rapidly. Results of these significant enhancements to the capacity of the database will better enable the mouse genetics and genomics research communities to find biological meaning in the mouse genome sequence. I will present the status of our sequence-to-biology ...
We investigate large functional genomics and high-throughput biological datasets. Assistance is provided in experimental design and subsequent analysis of next-generation sequencing, microarray, and mass-spectrometry-based proteomics experiments. The current focus is on the analysis of small RNA-Seq, mRNA-Seq and haploid ES cell screen data. Gene lists derived from publicly available studies or generated from in-house high-throughput experiments (NGS, microarray, proteomics) are analyzed for the overrepresentation of pathways, GO-terms, functional domains, or placed in interaction networks to visualize their relationships. Genome-wide expression patterns are contextualized with known processes and pathways using Gene Set Enrichment Analysis (GSEA). Local instances of integrated model organism databases and genome annotation portals permit visualization and analysis of in-house data with dedicated resources and additional privacy. User-driven data exploration is supported by the Ingenuity Pathway ...
Allows to align query sequences against those present in a selected target database. BLAST is a suite of programs, provided by NCBI, which can be used to quickly search a sequence database for matches to a query sequence. The software provides an access point for these tools to perform sequence alignment on the web. The set of BLAST command-line applications is organized in a way that groups together similar types of searches in one application.
Abstract Background While studies of non-model organisms are critical for many research areas, such as evolution, development, and environmental biology, they present particular challenges for both experimental and computational genomic level research. Resources such as mass-produced microarrays and the computational tools linking these data to functional annotation at the system and pathway level are rarely available for non-model species. This type of "systems-level" analysis is critical to the understanding of patterns of gene expression that underlie biological processes. Results We describe a bioinformatics pipeline known as FunnyBase that has been used to store, annotate, and analyze 40,363 expressed sequence tags (ESTs) from the heart and liver of the fish, Fundulus heteroclitus. Primary annotations based on sequence similarity are linked to networks of systematic annotation in Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) and can be queried and computationally ...
To whom it may concern: The completion of the sequencing of the entire DNA of the S. cerevisae genome, is a major event in the history of biology. All those involved are to be congratulated as we now have the first full genetic blueprint of a free living eukaryotic organism. The analysis of these gene products will provide us with a powerful tool for reading the genomes of other eukaryotes, particularly those of higher eukaryotes, which represent the majority of the data currently in the genetic databases. The analysis of the yeast genome is provided a useful framework for the annotation of many of the complete genome projects currently nearing completion, as well as the upcoming human genome. The yeast sequence information used to create this yeast webpage was provided by the GeneQuiz Consortium and the Mips Genome Commission . We have made an initial attempt to integrate these two data structures as well as supplement their annotation with that obtained ,From a set of functionally diagnostic ...
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari. ...
Find an active instance is here http://server3.eugenes.org/cgi-bin/gmod01/gbrowse/dev_chado_ggb/. The install steps included making a symlink from your Apache www/cgi-bin folder to this TEST_HOME/cgi-bin with gbrowse software. This gbrowse instance needs the correct path to TEST_HOME, and you may need adjustments when using Mod_Perl with Apache server.. At this point your web server should find this test gbrowse ast http://YOUR_SERVER/cgi-bin/gmod01/gbrowse/ with the Chado genome database as cgi-bin/gmod01/gbrowse/dev_chado_ggb/. If this fails, try the default gbrowse yeast data set as cgi-bin/gmod01/gbrowse/yeast_chr1/ Should this fail, so problem other than covered by this test example exists. If it works, and dev_chado_ggb/ fails, check the settings for your gbrowse.conf/dev_chado_ggb.conf. As needed, edit this setting to match your chado database name. database = dbi:Pg:dbname=dev_chado_01c;host=localhost. Check your web server error logs for messages from this software.. ...
Cyclome: Arabidopsis Cyclome Functional Genomics Database. gebd Arabidopsis Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Arabidopsis T-DNA/Ds, Full-length cDNA, Marker, EST, MPSS, SAGE, miRNA, sRNA, Arabidopsis Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
A program written by UCSC student Jim Kent, called GigAssembler, is used to periodically assemble a widely used public draft version of the human genome sequence using updated data from GenBank at the National Center For Biotechnology Information (NCBI). This assembly is steadily improving as the the public sequencing consortium churns out new data. We will look at the coverage statistics on the latest assembly, and then look at web tools to explore it, and what they find. The three most widely used public annotation browsers are the UCSC Genome browser (genome.ucsc.edu), the Ensembl genome browser (www.ensembl.org), and the NCBI map viewer (www.ncbi.nlm.nih.gov/genome/guide), the latter based on NCBIs own sequence assembly. We will focus on the UCSC browser, which shows a rich variety of data mapped to the genome sequence, including predicted genes, expressed sequence tags, full length mRNAs, genetic and radiation hybrid map markers, cytogenetically mapped clones, single nucleotide ...
BELARMINO, Luis C. et al. Mining plant genome browsers as a means for efficient connection of physical, genetic and cytogenetic mapping: an example using soybean. Genet. Mol. Biol. [online]. 2012, vol.35, n.1, suppl.1, pp.335-347. ISSN 1415-4757. http://dx.doi.org/10.1590/S1415-47572012000200015.. Physical maps are important tools to uncover general chromosome structure as well as to compare different plant lineages and species, helping to elucidate genome structure, evolution and possibilities regarding synteny and colinearity. The increasing production of sequence data has opened an opportunity to link information from mapping studies to the underlying sequences. Genome browsers are invaluable platforms that provide access to these sequences, including tools for genome analysis, allowing the integration of multivariate information, and thus aiding to explain the emergence of complex genomes. The present work presents a tutorial regarding the use of genome browsers to develop targeted physical ...
Many organisms have ≈24-h rhythms in metabolism, physiology, and behavior that are driven by cell autonomous circadian pacemakers (1). These circadian rhythms allow organisms to coordinate a myriad of physiological processes with the changing environment. In mammals, the circadian pacemaker is composed of interlocked transcription-translation feedback loops: the primary loop is composed of the basic helix-loop-helix transcription factors CLOCK and BMAL1, which drive transcription of the Period (Per1, Per2) and Cryptochrome (Cry1, Cry2) genes (1, 2). PER and CRY proteins form the negative limb of the feedback loop by inhibiting their own CLOCK:BMAL1-induced transcription; turnover of PER and CRY allows the cycle to begin anew. The interlocked loop consists of REV-ERB-α and RORα, which repress and activate the Bmal1 gene, thereby modulating its function (3, 4). Mutation or deletion of Clock (5), Bmal1 (6), Per1/2 genes (7, 8), or Cry1/2 (9, 10) genes results in behavioral arrhythmicity and ...
LanceletDB: The Lancelet (Branchiostoma belcheri) Genome Sequencing and Annotation Project Database at Sun Yat-sen University, Anlong Xu, Shangwu Chen, Shengfeng Huang, Yonggui Fu, Shengfeng Huang, Shaochun Yuan, Leiming You
An ontology of anatomical, cellular, and gene function phenotypes in Xenopus, the African clawed frogs. The Xenopus Phenotype Ontology represents and standardizes anatomical, cellular, and gene function phenotypes in Xenopus, the African clawed frogs. The XPO is being designed primarily to support phenotype curation in Xenbase, the model organism database for Xenopus, and to facilitate mappings between frog phenotypes and human disease ...
A draft of the complete human proteome has been available in UniProtKB/Swiss-Prot since 2008 and one of the current priorities of the Chordata protein annotation project is to improve the quality of human sequences provided.. See: What is the human complete proteome?. To this aim, we are updating sequences which show discrepancies with those predicted from the genome sequence. Dubious isoforms, sequences based on experimental artefacts and protein products derived from erroneous gene model predictions are also revisited. This work is in part done in collaboration with the Hinxton Sequence Forum (HSF), which allows active exchange between UniProt, HAVANA, Ensembl and HGNC groups, as well as with RefSeq database. UniProt is a member of the Consensus CDS project and we are in the process of reviewing our records to support convergence towards a standard set of protein annotation.. We also continuously update human entries with functional annotation, including novel structural, post-translational ...
BACKGROUND: Although, systematic analysis of gene annotation is a powerful tool for interpreting gene expression data, it sometimes is blurred by incomplete gene annotation, missing expression response of key genes and secondary gene expression responses. These shortcomings may be partially circumvented by instead matching gene expression signatures to signatures of other experiments. FINDINGS: To facilitate this we present the Functional Association Response by Overlap (FARO) server, that match input signatures to a compendium of 242 gene expression signatures, extracted from more than 1700 Arabidopsis microarray experiments. CONCLUSIONS: Hereby we present a publicly available tool for robust characterization of Arabidopsis gene expression experiments which can point to similar experimental factors in other experiments. The server is available at http://www.cbs.dtu.dk/services/faro ...
Human Phenotype Ontology:HP:0000212,MedGen:C0017567,Human Phenotype Ontology:HP:0000316,MedGen:CN000296,Human Phenotype Ontology:HP:0000821,MedGen:C0020676,Human Phenotype Ontology:HP:0001382,MedGen:C1844820,Human Phenotype Ontology:HP:0001636,MedGen:CN001489,Human Phenotype Ontology:HP:0002019,MedGen:C0009806,Human Phenotype Ontology:HP:0004322,MedGen:C0349588,Human Phenotype Ontology:HP:0012471,MedGen:C1836543,MeSH:C536914,MedGen:C0238462,Orphanet:ORPHA1332,SNOMED CT:255032005,MeSH:D013964,MedGen:C0040136,MeSH:D018761,MedGen:C0025267,OMIM:131100,Orphanet:ORPHA652,SNOMED CT:30664006,MeSH:D018813,MedGen:C0025268,OMIM:171400,Orphanet:ORPHA247698,SNOMED CT:61808009,MeSH:D018814,MedGen:C0025269,OMIM:162300,Orphanet:ORPHA247709,SNOMED CT:6153000,SNOMED CT:61530001,MedGen:C0031511,OMIM:171300,MedGen:C1833929,MedGen:C1970712,OMIM:610755,Orphanet:ORPHA276152,MedGen:CN073359,Orphanet:ORPHA653,SNOMED CT:61808009,MedGen:CN169374,MedGen: ...
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
Web Portal for International Cancer Research: Cancer Epidemiology and Genetic Databases, Research Programmes, Electronic Publications, Scientific Papers, IARC Press Releases, IARC Training Courses, IARC Fellowships for Cancer Research, IARC Meetings, etc
NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.. Sources Used in Current Review. MedlinePlus Medical Encylopedia. Complement. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003456.htm. Accessed March 2014.. MedlinePlus Medical Encyclopedia. Complement component 3 (C3). Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003539.htm. Accessed March 2014.. MedlinePlus Medical Encyclopedia. Complement component 4. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003354.htm. Accessed March 2014.. ARUP Consult. Complement Deficiency. Available online at ...
Summary: Genoscape is an open-source Cytoscape plug-in that visually integrates gene expression data sets from GenoScript, a transcriptomic database, and KEGG pathways into Cytoscape networks. The generated visualisation highlights gene expression changes and their statistical significance. The plug-in also allows one to browse GenoScript or import transcriptomic data from other sources through tab-separated text files. Genoscape has been successfully used by researchers to investigate the results of gene expression profiling experiments.. Availability: Genoscape is an open-source software freely available from the Genoscape webpage (http://www.pasteur.fr/recherche/unites/Gim/genoscape/). Installation instructions and tutorial can also be found at this URL.. Contact: [email protected]; [email protected] Supplementary information: Supplementary data are available at Bioinformatics online.. ...
This project is an investigation of whether analysing subsets of time series gene expression data can give additional information about putatively co-regulated genes, compared to only using the whole time series. The original gene expression data set was partitioned into subsets and similarity was computed for both the whole timed series and subsets. Pearson correlation was used as similarity measure between gene expression profiles. The results indicate that analysing co-expression in subsets of gene expression data derives true-positive connections, with respect to co-regulation, that are not detected by only using the whole time series data. Unfortunately, with the actual data set, chosen similarity measure and partitioning of the data, randomly generated connections have the same amount of true-positives as the ones derived by the applied analysis. However, it is worth to continue further analysis of the subsets of gene expression data, which is based on the multi-factorial nature of gene ...
A relational database is a digital database based on the relational model of data, as proposed by E. F. Codd in 1970. A software system used to maintain relational databases is a relational database management system (RDBMS). Virtually all relational database systems use SQL (Structured Query Language) for querying and maintaining the database. This model organizes data into one or more tables (or "relations") of columns and rows, with a unique key identifying each row. Rows are also called records or tuples. Columns are also called attributes. Generally, each table/relation represents one "entity type" (such as customer or product). The rows represent instances of that type of entity (such as "Lee" or "chair") and the columns representing values attributed to that instance (such as address or price). Each row in a table has its own unique key. Rows in a table can be linked to rows in other tables by adding a column for the unique key of the linked row (such columns are known as foreign keys). ...
Sources Used in Current Review. Farinde, A. (Updated 2014 July 2). Human Chorionic Gonadotropin (hCG). Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/2089158-overview through http://emedicine.medscape.com. Accessed September 2014.. (Updated 2014 June 5). Pregnancy. U.S. Food and Drug Administration Medical Devices [On-line information]. Available online at http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/InVitroDiagnostics/HomeUseTests/ucm126067.htm through http://www.fda.gov. Accessed September 2014.. Grenache, D. and Lehman, C. (Updated 2012 November). hCG Testing hCG. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/hCG.html?client_ID=LTD through http://www.arupconsult.com. Accessed September 2014.. Rollins, G. (2012 March 8). Taking a New Look at the hCG Discriminatory Level. Clinical Laboratory Strategies [On-line information]. Available online at ...
RiceGE : Rice Functional Genomics Database. gebd Rice Genome Browser. iSect Tools, iView Tools and Gene Expression Atlas. Collection of Rice T-DNA/Ds, Rice cDNA, Marker, EST, MPSS, SAGE, Arabidopsis, Maize, Wheat, Barley Homology, Rice Tiling Array and Gene Expression Data. Created and developed by Huaming Chen
Modern DNA sequencing technologies enable geneticists to rapidly identify genetic variation among many human genomes. However, isolating the minority of variants underlying disease remains an important, yet formidable challenge for medical genetics. We have developed GEMINI (GEnome MINIng), a flexible software package for exploring all forms of human genetic variation. Unlike existing tools, GEMINI integrates genetic variation with a diverse and adaptable set of genome annotations (e.g., dbSNP, ENCODE, UCSC, ClinVar, KEGG) into a unified database to facilitate interpretation and data exploration. Whereas other methods provide an inflexible set of variant filters or prioritization methods, GEMINI allows researchers to compose complex queries based on sample genotypes, inheritance patterns, and both pre-installed and custom genome annotations. GEMINI also provides methods for ad hoc queries and data exploration, a simple programming interface for custom analyses that leverage the underlying database, and
Grapevine is an important perennial fruit to the wine industry, and has implications for the health industry with some causative agents proven to reduce heart disease. Since the sequencing and assembly of grapevine cultivar Pinot Noir, several studies have contributed to its genome annotation. This new study further contributes toward genome annotation efforts by conducting a proteogenomics analysis using the latest genome annotation from CRIBI, legacy proteomics dataset from cultivar Cabernet Sauvignon and a large RNA-seq dataset. A total of 341 novel annotation events are identified consisting of five frame-shifts, 37 translated UTRs, 15 exon boundaries, one novel splice, nine novel exons, 159 gene boundaries, 112 reverse strands, and one novel gene event in 213 genes and 323 proteins. From this proteogenomics evidence, the Augustus gene prediction tool predicted 52 novel and revised genes (54 protein isoforms), 11 genes of which are associated with key traits such as stress tolerance and ...
FlyBase: the Drosophila genes and genomes database. BestGene: the Drosophila embryo injection and transgenic service. Bloomington Drosophila Stock Center (flystocks) at Indiana University. Deletion Hunter: a tool to identify FRT site compatible for at will genomic deletion. Drosophila Genomics Resource Center (DGRC) at Indiana University. Drosophila Image Award by the Genetics Society of America. Drosophila Species Stock Center (DSSC) at University of California San Diego. Drosophila RNAi Screening Center (DRSC & TRiP) at Harvard Medical School. Exelixis Collection at Harvard Medical School. FlyAtlas: the Drosophila gene expression atlas (see the brand new search page FlyAtlas2). FlyC31: the PhiC31 integrase system for Drosophila transgenics. FlyCRISPR: the powerful RNA-guided gene editing method applied to Drosophila. FlyMine: an integrated genomics database for Drosophila. FlyMove: an internet resource to study the development of the fruit fly. FlyORF: the UAS-ORF lines project at Zurich ...
A meta-analysis was performed across six public microarray datasets for human small cell lung cancer (SCLC) comprising 365 samples across eight different platforms. Genes were ranked according to effect size and p-value for tumor versus control samples, and false discovery rates were calculated. The top scoring 48 genes that were significant by both methods, along with the 48 highest rated surface antigen genes, were used to populate a gene list for subsequent single cell evaluation. High throughput gene expression analysis was performed for 400 individual cells from one SCLC line (H446) using the Fluidigm microfluidic platform. Supervised machine learning was applied to identify transcriptionally-defined subgroups among these cells. The non-parametric Kolmogorov-Smirnov test was then used to determine those surface markers best able to distinguish each cluster. Individual cells from each group were then FACS-isolated, and clonogenicity was evaluated after 14 days in culture. Using these surface ...
LOCUS XP_001001333 155 aa linear ROD 28-SEP-2012 DEFINITION PREDICTED: 60S ribosomal protein L23a-like [Mus musculus]. ACCESSION XP_001001333 VERSION XP_001001333.1 DBSOURCE REFSEQ: accession XM_001001333.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_187034) annotated using gene prediction method: GNOMON. Also see: Documentation of NCBIs Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ...
Frequency of INherited Disorders database (FINDbase) (http://www.findbase.org) is a relational database, derived from the ETHNOS software, recording frequencies of causative mutations leading to inherited disorders worldwide. Database records include the population and ethnic group, the disorder name and the related gene, accompanied by links to any corresponding locus-specific mutation database, to the respective Online Mendelian Inheritance in Man entries and the mutation together with its frequency in that population. The initial information is derived from the published literature, locus-specific databases and genetic disease consortia. FINDbase offers a user-friendly query interface, providing instant access to the list and frequencies of the different mutations. Query outputs can be either in a table or graphical format, accompanied by reference(s) on the data source. Registered users from three different groups, namely administrator, national coordinator and curator, are responsible for ...
Gene functional annotations are an essential part of knowledge discovery in the analysis of large datasets, with the Gene Ontology [Ashburner et al., 2000] as the de facto standard for such annotations. A considerable number of approaches for quantifying functional similarity between gene products based on the semantic similarity between their annotations have been developed, but little guidance exists as to which of these measures are the most appropriate for different purposes. This was addressed here by comparing the performances of a number of similarity measures and associated parameters. This comparison provided some interesting new insights as well as confirming emerging trends from the literature. There is also a pressing need for novel ways of applying these measures to facilitate the functional analysis of lists of gene products. We developed a novel algorithm, FuSiGroups, to group GO terms based on their semantic similarity and genes based on their functional similarity. This two-fold ...
Chapter 1: Getting Started Hello and welcome to MySQL Training. Im Ayumilove and I am going to be taking you from absolute beginner level to a mastery of MySQL where you will be able design and develop your own complex Database Management Systems. I dont expect you to know anything about database at this point…
Database Management Short Questions to test Database concept : DBMS is the short form of Database Management System. DBMS is a collection of computer progr but it is easy to understand if you attempt this DBMS / RDBMS quiz online. Database Management System (DBMS) quiz question bank in PDf format for download will be added soon.
An automatic testing application is provided that can simulate a user interaction with a web application. The automatic testing application can determine that the web application has been completely displayed within a graphical user interface of a web browser using a consistent global page state. The automatic testing application can test that the web application has been correctly displayed by verifying a state of a visualization component of the web application using a communication component. Subsequently, the automatic testing application can transmit an event to the web application that can modify the state of the visualization component using the communication component. Once the automatic testing application has determined that the web application has been completely re-displayed, using the consistent global page state, the automatic testing application can test that the web application has been correctly re-displayed by verifying a modified state of the visualization component using the
BACKGROUND: Calls have been made for increased access to individual participant data (IPD) from clinical trials, to ensure that complete evidence is available. However, despite the obvious benefits, progress towards this is frustratingly slow. In the meantime, many systematic reviews have already collected IPD from clinical trials. We propose that a central repository for these IPD should be established to ensure that these datasets are safeguarded and made available for use by others, building on the strengths and advantages of the collaborative groups that have been brought together in developing the datasets. OBJECTIVE: Evaluate the level of support, and identify major issues, for establishing a central repository of IPD. DESIGN: On-line survey with email reminders. PARTICIPANTS: 71 reviewers affiliated with the Cochrane Collaborations IPD Meta-analysis Methods Group were invited to participate. RESULTS: 30 (42%) invitees responded: 28 (93%) had been involved in an IPD review and 24 (80%) had been
In this article, we combine multi-level profiling methods with bioinformatic and theoretical modeling approaches to characterize the molecular repertoire of C. reinhardtii under reference conditions. We analyzed and integrated (i) a combination of database resources, such as existing genome annotations from JGI v3.1, EST collections, six-frame translation of the genomic sequence, protein domain scanning, and pathway annotation information; (ii) systematic high-resolution shotgun proteomics for high-throughput protein identification; (iii) systematic metabolite profiling and projection of identified metabolites to the reconstructed metabolic draft network in Chlamydomonas on the basis of existing gene annotation; and (iv) structural modeling of the reconstructed metabolic network to identify minimum extension pathways on the basis of the presence of identified metabolites.. MapMan classification of the predicted Chlamydomonas protein set and comparison with other organisms yielded information for ...
Various embodiments include one or more of systems, methods, software, and data structures that allow dual access to concurrent data in a database management system including uncommitted updated data. Some embodiments include a dual snapshot of data in a multi-version concurrency control style database, but the embodiments described herein are equally applicable to virtually any other type of database and database management system.
MGI protein superfamily detail pages represent the protein classification set for a homeomorphic superfamily from the Protein Information Resource SuperFamily (PIRSF) site.. Mouse superfamily members are shown with links to their corresponding HomoloGene Classes. Note that pseudogenes are included in PIRSF families but not in orthology sets used here. You can select a given mouse superfamily member and download (or forward to NCBI BLAST) FASTA formatted protein sequences of that mouse gene and its mouse, human and rat homologs, as defined in the corresponding HomoloGene Class. The numbers of mouse, human and rat genes in the HomoloGene Class are shown. You can also "Select all" mouse superfamily members to obtain their protein sequences and the protein sequences for all mouse, human and rat homologs of the mouse superfamily members.. The number of protein sequences returned does not always match the numbers of homologs shown, because the same protein sequence can be associated with multiple ...
This is a solution of Advantages Of Database Management Systems that describes about Developing business Advantages Of Database Management Systems Qualification Unit number and title Pearson BTEC ...
Database Management Systems provides comprehensive and up-to-date coverage of the fundamentals of database systems. Coherent explanations and practical examples have made this one of the leading texts in the field. The third edition continues in this tradition, enhancing it with more practical material. The new edition has been reorganized to allow more flexibility in the way the course is taught. Now, instructors can easily choose whether they would like to teach a course which emphasizes database application development or a course that emphasizes database systems issues. New overview chapters at the beginning of parts make it possible to skip other chapters in the part if you dont want the detail. More applications and examples have been added throughout the book, including SQL and Oracle examples. The applied flavor is further enhanced by the two new database applications chapters.
Oracle Health Sciences has released the Oracle Health Sciences Omics Data Bank, a molecular data model, part of Oracle Health Sciences Translational Research Center. The new data model provides integration and analysis of cross-platform omics data to support translational research.. The Omics Data Bank enables turnkey integration and analysis of multiple types of molecular data, including whole genome sequencing and gene expression data irrespective of the platform used. The omics data model allows researchers to analyze large molecular data sets from internal and external sources more efficiently.. The solution also includes out-of-the-box adapters for loading customer-generated molecular profiling data, as well as public domain data from sources such as Ensembl, The Cancer Genome Atlas andPathwayCommons, to further speed time to value.. OracleHealthSciencesTranslationalResearchCenterruns on Oracle Exadata Database Machine.. ...
CS 6379 Biological Database Systems and Data Mining (3 semester hours) Relational data models and database management systems; theories and techniques of constructing relational databases to store biological data, including sequences, structures, genetic linkages and maps, and signal pathways. Introduction to a relational database query language (SQL) with emphasis on answering biologically important questions. Summary of current biological databases. Data integration from various sources and security. Novel data mining methods in bioinformatics with an emphasis on protein structure prediction, homology search, genomic sequence analysis, gene finding and gene mapping. Future directions for biological database development. Prerequisites: BIOL6373/BMEN 6391, BIOL 5381, and CS 5343 or consent of the instructor. (3-0) T ...
3,5-cyclic-GMP phosphodiesterase - Wikipedia  3',5'-cyclic-GMP phosphodiesterase - Wikipedia
... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3,5-GMP phosphodiesterase, cyclic guanosine 3,5- ... Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3,5-cyclic phosphate ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3,5-phosphate phosphodiesterase. As of ...
more infohttps://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase
Pde11a - Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A - Mus musculus (Mouse) - Pde11a gene & protein  Pde11a - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Mus musculus (Mouse) - Pde11a gene & protein
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. ... Catalyzes the hydrolysis of both cAMP and cGMP to 5-AMP and 5-GMP, respectively (By similarity). ... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: UniProtKB. *cyclic-nucleotide phosphodiesterase activity ... cyclic-AMP and -GMP phosphodiesterase 11AAdd BLAST. 933. Amino acid modifications. Feature key. Position(s). DescriptionActions ...
more infohttps://www.uniprot.org/uniprot/P0C1Q2
PDE6G - Retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit gamma - Canis lupus familiaris (Dog) -...  PDE6G - Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma - Canis lupus familiaris (Dog) -...
... cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC. *cGMP binding Source: InterPro. View the complete GO annotation on ... cyclic phosphodiesterase subunit gammaAdd BLAST. 87. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... cyclic phosphodiesterase subunit gamma OS=Canis lupus familiaris OX=9615 GN=PDE6G PE=3 SV=1 ... p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and ...
more infohttp://www.uniprot.org/uniprot/P54827
Pde6g MGI Mouse Gene Detail - MGI:97526 - phosphodiesterase 6G, cGMP-specific, rod, gamma  Pde6g MGI Mouse Gene Detail - MGI:97526 - phosphodiesterase 6G, cGMP-specific, rod, gamma
J:32329 Tuteja N, et al., Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid ... 5 phenotypes from 1 allele in 1 genetic background 2 phenotypes from multigenic genotypes 18 phenotype references ...
more infohttp://www.informatics.jax.org/marker/MGI:97526
PDE6B Gene - GeneCards | PDE6B Protein | PDE6B Antibody  PDE6B Gene - GeneCards | PDE6B Protein | PDE6B Antibody
Phosphodiesterase 6B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Belongs to the cyclic nucleotide phosphodiesterase family.. Family:. * Belongs to the cyclic nucleotide phosphodiesterase ... GMP-PDE Beta 3 4 * EC 3.1.4.35 4 58 * PDEB 3 4 ... PDE6B (Phosphodiesterase 6B) is a Protein Coding gene. Diseases ... A novel mutation in exon 17 of the beta-subunit of rod phosphodiesterase in two RP sisters of a consanguineous family. (PMID: ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=PDE6B&keywords=GH04H000637&prefilter=genomic_location
Gentaur Molecular :GenWay \ Retinal rod rhodopsin-sensitive cGMP 3.5-cyclic phosphodiesterase subunit delta - EC 3.1.4.17;...  Gentaur Molecular :GenWay \ Retinal rod rhodopsin-sensitive cGMP 3'.5'-cyclic phosphodiesterase subunit delta - EC 3.1.4.17;...
... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein \ 10-288-22226F for more molecular products ... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein ... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein Related products : Retinal rod rhodopsin- ... cyclic phosphodiesterase subunit delta - EC 3.1.4.17; GMP-PDE delta; p17 protein / Product Detail : 10-288-22226F Retinal rod ...
more infohttp://www.antibody-antibodies.com/product_det.php?id=1880995&supplier=search&name=Retinal%20rod%20rhodopsin_sensitive%20cGMP%203
Frontiers | AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and...  Frontiers | AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and...
In addition, a clear therapeutic effect was present in mice treated at 2 weeks of age as well as in mice treated at 3 months of ... In addition, a clear therapeutic effect was present in mice treated at 2 weeks of age as well as in mice treated at 3 months of ... Specifically, we compare the influence of two different AAV vector capsids, AAV2/5 (Y719F) and AAV2/8 (Y733F), on restoration ... Specifically, we compare the influence of two different AAV vector capsids, AAV2/5 (Y719F) and AAV2/8 (Y733F), on restoration ...
more infohttps://www.frontiersin.org/articles/10.3389/fnins.2017.00292/full
Recombinant Human PDE6B 293 Cell Lysate PDE6B-3346HCL - Creative BioMart  Recombinant Human PDE6B 293 Cell Lysate PDE6B-3346HCL - Creative BioMart
GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit; CSNBAD2;. ... Antigen standard for phosphodiesterase 6B, cGMP-specific, rod, ... PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; ... This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading ... Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM ...
more infohttps://www.creativebiomart.net/description_405012_318.htm
Gene Info  Gene Info
... cyclic-GMP phosphodiesterase activity *[MF] calmodulin-dependent cyclic-nucleotide phosphodiesterase activity *[MF] hydrolase ... cyclic-AMP phosphodiesterase activity *[MF] cGMP binding *[MF] calcium- and calmodulin-regulated 3,5- ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=40678&LLNO=18573
Recombinant Human PDE10A 293 Cell Lysate PDE10A-3355HCL - Creative BioMart  Recombinant Human PDE10A 293 Cell Lysate PDE10A-3355HCL - Creative BioMart
... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; nucleotide binding; ... phosphodiesterase 10A1 (PDE10A1); dJ416F21.1 (phosphodiesterase 10A); HSPDE10A; FLJ11894; FLJ25677;. ... Antigen standard for phosphodiesterase 10A (PDE10A), transcript variant 2 is a lysate prepared from HEK293T cells transiently ... PDE10A; phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A; ...
more infohttps://www.creativebiomart.net/description_405021_318.htm
tadalafil (CHEBI:71940)  tadalafil (CHEBI:71940)
... cyclic-GMP phosphodiesterase) inhibitor (CHEBI:71942) tadalafil (CHEBI:71940) has role vasodilator agent (CHEBI:35620) ... cyclic-GMP phosphodiesterase) inhibitor An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that blocks the action of 3,5- ... A phosphodiesterase V inhibitor inhibitor, currently marketed in pill form for treating erectile dysfunction under the name ... BENZO[1,3]DIOXOL-. 5-. YL-. 2-. METHYL-. 2,3,6,7,12,12A-. HEXAHYDRO-. PYRAZINO[1,2:1,6]PYRIDO[3,4-. B]INDOLE-. 1,4-. DIONE ...
more infohttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:71940
urinary tract neoplasms benign drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine  urinary tract neoplasms benign drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Cyclic-GMP Phosphodiesterases / antagonists & inhibitors. Animals. Autonomic Nervous System / drug effects. Autonomic Nervous ... Chemical-registry-number] 0 / Actins; EC 2.7.11.12 / Cyclic GMP-Dependent Protein Kinases; H2D2X058MU / Cyclic GMP ... MeSH-major] Cyclic GMP-Dependent Protein Kinases / metabolism. Prostate / enzymology. Prostatic Neoplasms / enzymology ... Immunohistochemical distribution of cyclic GMP-dependent protein kinase-1 in human prostate tissue. Eur Urol; 2007 Aug;52(2): ...
more infohttp://www.bmlsearch.com/?kwr=urinary+tract+neoplasms+benign+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
Phosphodiesterase 2 - Wikipedia  Phosphodiesterase 2 - Wikipedia
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs ... cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism" (PDF). Gen Physiol Biophys. 22 ... "Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use". Pharmacol. Rev. 58 (3): 488-520. doi:10.1124/pr. ...
more infohttps://en.wikipedia.org/wiki/PDE2
Achromatopsia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials  Achromatopsia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
... cyclic-GMP phosphodiesterase activity. GO:0047555 9.46. PDE6C PDE6H 3. 3,5-cyclic-nucleotide phosphodiesterase activity. GO: ... intracellular cyclic nucleotide activated cation channel activity. GO:0005221 9.32. CNGB1 CNGB3 ... Cyclic Nucleotide Gated Channel Beta 3. Protein Coding. 831.74. Pathogenic/Likely pathogenic 6 ... Cyclic Nucleotide Gated Channel Alpha 3. Protein Coding. 821.14. Pathogenic/Likely pathogenic 6 ...
more infohttps://www.malacards.org/card/achromatopsia
Overview: tpbB, Pseudomonas aeruginosa PAO1
	  Overview: tpbB, Pseudomonas aeruginosa PAO1
YfiBNR mediates cyclic di-GMP dependent small colony variant formation and persistence in Pseudomonas aeruginosa. ... Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3-5)-cyclic-GMP in ... Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine ...
more infohttp://www.pseudomonas.com/feature/show?id=105008
Panoply™ Human PDE6B Knockdown Stable Cell Line - Creative Biogene  Panoply™ Human PDE6B Knockdown Stable Cell Line - Creative Biogene
GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit; CSNBAD2; ... PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta [ Homo ... AAV Service Adenovirus Service Baculovirus Service GMP Grade Viral Service Herpes Simplex Virus (HSV) Service Lentivirus ... PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; ... 3,5-cyclic-GMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; ...
more infohttps://www.creative-biogene.com/Panoply-Human-PDE6B-Knockdown-Stable-Cell-Line-CSC-DC011510-1264529-14.html
SMART: Secondary literature for GAF domain  SMART: Secondary literature for GAF domain
Bovine rhodopsin: amino acid substitutions Asp-83----Asn and Glu-134----Gln prevent activation of cyclic GMP phosphodiesterase. ... Extracts prepared from yeast expressing the human PDE2A3 hydrolyzed both cyclic AMP (cAMP) and cyclic GMP (cGMP). This activity ... but were completely unable to activate cyclic GMP phosphodiesterase. ... Human cyclic GMP-stimulated 3,5-cyclic nucleotide phosphodiesterase (PDE2A3) cDNAs were cloned from hippocampus and fetal ...
more infohttp://smart.embl.de/smart/show_secondary.cgi?domain=GAF
Human Metabolome Database: Showing metabocard for Cyclic GMP (HMDB0001314)  Human Metabolome Database: Showing metabocard for Cyclic GMP (HMDB0001314)
Design and synthesis of xanthines and cyclic GMP analogs as potent inhibitors of PDE5. Phosphodiesterase Inhibitors (1996), 135 ... Cyclic GMP. Description. Guanosine cyclic 3,5-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which ... cyclic nucleotide phosphodiesterase 1A. General function:. Involved in catalytic activity. Specific function:. Cyclic ... cyclic nucleotide phosphodiesterase 1B. General function:. Involved in catalytic activity. Specific function:. Cyclic ...
more infohttp://www.hmdb.ca/metabolites/HMDB0001314
PDE11A Antibody (NBP1-85919): Novus Biologicals  PDE11A Antibody (NBP1-85919): Novus Biologicals
... cyclic-AMP and -GMP phosphodiesterase 11A. *EC 3.1.4. *EC 3.1.4.17 ... Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp ... cAMP and cGMP cyclic nucleotide phosphodiesterase 11A. *cAMP ...
more infohttps://www.novusbio.com/products/pde11a-antibody_nbp1-85919
ASMscience | 26 Multispecies Interact  ASMscience | 26 Multispecies Interact
5-dihydroxy-2,3-pentanedione (DPD) was critical for maximal biofilm development. One site where natural multispecies biofilms ... Tischler, A. D., and, A. Camilli. 2004. Cyclic diguanylate (c-di-GMP) regulates Vibrio cholerae biofilm formation. Mol. ... Kirillina, O.,, J. D. Fetherston,, A. G. Bobrov,, J. Abney, and, R. D. Perry. 2004. HmsP, a putative phosphodiesterase, and ... Control of formation and cellular detachment from Shewanella oneidensis MR-1 biofilms by cyclic di-GMP. J. Bacteriol. 188:2681- ...
more infohttp://www.asmscience.org/content/book/10.1128/9781555815677.ch26
  • Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). (pseudomonas.com)
  • The steps of biofilm formation, as described in this article are (1) reversible attachment, likely via the flagellar pole, (2) irreversible attachment via the long axis of the cell, resulting in a monolayer of cells, (3) microcolony formation, (4) macrocolony formation, and (5) dispersion. (asmscience.org)
  • Phenotypic studies revealed that ml1419c expression altered colony morphology, motility and biofilm formation of P. aeruginosa PAO1 in a manner consistent with increased cyclic di-GMP production. (microbiologyresearch.org)
  • These studies demonstrated that ML1419c of M. leprae functions as diguanylate cyclase to synthesize cyclic di-GMP. (microbiologyresearch.org)
  • Thus, this protein was renamed DgcA (Diguanylate cyclase A). These results also demonstrated the ability to use P. aeruginosa as a heterologous host for characterizing the function of proteins involved in the cyclic di-GMP pathway of a pathogen refractory to in vitro growth, M. leprae . (microbiologyresearch.org)
  • Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum. (embl.de)
  • Inhibition of cGMP-specific phosphodiesterase type V (PDE5) has been shown to improve penile erection in patients with erectile dysfunction. (embl.de)
  • Manish, B. 3D QSAR, pharmacophore indentification studies on series of 1-(2-ethoxyethyl)-1H-pyrazolo[4,3-d] pyrimidines as PDE5 inhibitors. (eurekaselect.com)
  • Importantly, an optimal concentration of 4,5-dihydroxy-2,3-pentanedione (DPD) was critical for maximal biofilm development. (asmscience.org)
  • Direct measurement of cyclic di-GMP levels by liquid chromatography-mass spectrometry confirmed that ml1419c expression increased cyclic di-GMP production in P. aeruginosa PAO1 cultures in comparison to the vector control. (microbiologyresearch.org)
  • those with an EAL domain linearize the molecule to produce pGpG, and proteins with an HD-GYP domain generate two molecules of GMP from the signal. (asmscience.org)
  • We have previously shown in the Cnga 3 knockout (KO) mouse model of ACHM2 that gene supplementation therapy is effective in rescuing cone function and morphology and delaying cone degeneration. (frontiersin.org)
  • Specifically, we compare the influence of two different AAV vector capsids, AAV2/5 (Y719F) and AAV2/8 (Y733F), on restoration of cone function, and assess the effect of age at time of treatment on the long-term outcome. (frontiersin.org)
  • We found that both vector capsid serotypes led to a comparable rescue of cone function over the observation period between 4 weeks and 3 months post treatment. (frontiersin.org)
  • This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. (creativebiomart.net)
  • Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). (creativebiomart.net)
  • The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). (creativebiomart.net)
  • In addition, a clear therapeutic effect was present in mice treated at 2 weeks of age as well as in mice treated at 3 months of age at the first assessment at 4 weeks after treatment. (frontiersin.org)
  • In summary, we found that the therapeutic time window of opportunity for AAV-mediated Cnga3 gene supplementation therapy in the Cnga3 KO mouse model extends at least to an age of 3 months, but is presumably limited by the condition, number and topographical distribution of remaining cones at the time of treatment. (frontiersin.org)
  • Achromatopsia, also known as total color blindness , is related to achromatopsia 4 and achromatopsia 2 , and has symptoms including photophobia An important gene associated with Achromatopsia is PDE6C (Phosphodiesterase 6C), and among its related pathways/superpathways are Phototransduction and Metabolism of fat-soluble vitamins . (malacards.org)
  • Studies have shown that cGMP synthesis in cones is about 5-10 times higher than it is in rods, which may play an important role in modulating cone adaption to light. (wikipedia.org)
  • 5 Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, USA. (jci.org)