3',5'-Cyclic-AMP Phosphodiesterases: Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Cyclic Nucleotide Phosphodiesterases, Type 4: A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.Cyclic Nucleotide Phosphodiesterases, Type 3: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.Phosphoric Diester Hydrolases: A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.Cyclic Nucleotide Phosphodiesterases, Type 1: A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.Cyclic Nucleotide Phosphodiesterases, Type 2: A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.3',5'-Cyclic-GMP Phosphodiesterases: Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.Phosphodiesterase Inhibitors: Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.2',3'-Cyclic-Nucleotide Phosphodiesterases: Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.Cyclic Nucleotide Phosphodiesterases, Type 5: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.Rolipram: A phosphodiesterase 4 inhibitor with antidepressant properties.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Cyclic Nucleotide Phosphodiesterases, Type 7: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own tissue localization. The isoforms are encoded by at least two genes and are a product of multiple alternative splicing of their mRNAs.1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASESNucleotides, CyclicPurinonesAntibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Receptors, Glucocorticoid: Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Phosphodiesterase 4 Inhibitors: Compounds that specifically inhibit PHOSPHODIESTERASE 4.CyclopropanesAminopyridines: Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Carps: Common name for a number of different species of fish in the family Cyprinidae. This includes, among others, the common carp, crucian carp, grass carp, and silver carp.Macrophage Activation: The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.Refractometry: Measurement of the index of refraction (the ratio of the velocity of light or other radiation in the first of two media to its velocity in the second as it passes from one into the other).Birefringence: The property of nonisotropic media, such as crystals, whereby a single incident beam of light traverses the medium as two beams, each plane-polarized, the planes being at right angles to each other. (Cline et al., Dictionary of Visual Science, 4th ed)Microscopy, Polarization: Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.Macrophages, Peritoneal: Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.Myxomycetes: A division of organisms that exist vegetatively as complex mobile plasmodia, reproduce by means of spores, and have complex life cycles. They are now classed as protozoa but formerly were considered fungi.Dictyostelium: A genus of protozoa, formerly also considered a fungus. Its natural habitat is decaying forest leaves, where it feeds on bacteria. D. discoideum is the best-known species and is widely used in biomedical research.Dictyosteliida: An order of protozoa characterized by their ability to aggregate to form a multicellular pseudoplasmodium, which gives rise to a multispored fruiting body. A stalk tube is present.Cellophane: A generic name for film produced from wood pulp by the viscose process. It is a thin, transparent sheeting of regenerated cellulose, moisture-proof and sometimes dyed, and used chiefly as food wrapping or as bags for dialysis. (Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)BooksHexanones: 6-carbon straight-chain or branched ketones.Physarum polycephalum: A protozoan, previously also considered a fungus. Characteristics include sporangia that are stalked and multilobed. It is widely used in biomedical research.Megakaryocytes: Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.Iloprost: An eicosanoid, derived from the cyclooxygenase pathway of arachidonic acid metabolism. It is a stable and synthetic analog of EPOPROSTENOL, but with a longer half-life than the parent compound. Its actions are similar to prostacyclin. Iloprost produces vasodilation and inhibits platelet aggregation.Pituitary Adenylate Cyclase-Activating Polypeptide: A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.Receptors, Epoprostenol: Cell surface receptors for EPOPROSTENOL. They are coupled to HETEROTRIMERIC G-PROTEINS.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Esophageal Sphincter, Lower: The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Manometry: Measurement of the pressure or tension of liquids or gases with a manometer.Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Esophageal Achalasia: A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
... cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclic ... Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ...
cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ...
"Ontogenic development of a phosphodiesterase activator and the multiple forms of cyclic AMP phosphodiesterase of rat brain". ... A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ... as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases ...
... cyclic-AMP phosphodiesterase Phosphodiesterase PDE4 inhibitor. ... At least four types of the enzyme phosphodiesterase 4 (PDE4) ...
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate ...
... and it is long-acting because it is resistant to degradation by cyclic AMP phosphodiesterase. 8-Bromoguanosine 3',5'-cyclic ... is a brominated derivative of cyclic adenosine monophosphate (cAMP). 8-Br-cAMP is an activator of cyclic AMP-dependent protein ... cyclic monophosphate at Sigma-Aldrich 8-Bromo Cyclic Adenosine Monophosphate at PubChem. ...
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso, G.D.; ...
"Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". The ... Helfman DM, Kuo JF (Jan 1982). "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- ... Nov 2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase ... selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium". ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... alkylglycerophosphoethanolamine phosphodiesterase activity. • macromolecular complex binding. Cellular component. • ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[5] ... This gene uses alternative polyadenylation signals.[5][6] Interactive pathway map[edit]. Click on genes, proteins and ...
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... An example is adenylate cyclase, which produces the second messenger cyclic AMP.[6] For this discovery, they won the 1994 Nobel ... which produces the second messenger cyclic AMP.[6]. *The 1988 Nobel Prize in Physiology or Medicine to George H. Hitchings, Sir ... cyclic-GMP phosphodiesterase. *Protein kinase G. *G alpha subunit Gα *GNAO1 ...
cAMP phosphodiesterase converts cAMP into AMP by breaking the phosphodiester bond, in turn reducing the cAMP levels ... Kaupp UB, Seifert R (July 2002). "Cyclic nucleotide-gated ion channels". Physiol. Rev. 82 (3): 769-824. CiteSeerX 10.1.1.319. ... caffeine and theophylline inhibit cAMP phosphodiesterase, which degrades cAMP - thus enabling higher levels of cAMP than would ... bucladesine (dibutyryl cAMP, db cAMP) - also a phosphodiesterase inhibitor. *pertussis toxin, which increases cAMP levels by ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... doi:10.1016/S0969-2126(01)00259-3. PMID 8591034.. *^ Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble ... 9 (1): 22-3. doi:10.4161/cc.9.1.10735. PMID 20016257.. *^ Baumann K (November 2013). "Cell cycle: Cyclin A corrections". Nature ... cyclin D 1,2,3 (Cdk4, Cdk6) cyclin E (Cdk2) cyclin A (Cdk2, Cdk1) cyclin B (Cdk1) ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ...
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. cAMP is a second messenger, used for intracellular ... such as cyclic adenosine monophosphate, cyclic AMP). Cyclic AMP is synthesized from ATP by adenylate cyclase located on the ... Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in ... In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on ... Because RETGC-1 produces cGMP, which keeps cyclic nucleotide-gated channels open allowing the influx of calcium, this mutation ... doi:10.1007/978-3-540-68964-5_2.. *^ Tseng K, Caballero A, Dec A, Cass D, Simak N, Sunu E, Park M, Blume S, Sammut S, Park D, ...
Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current ... Némoz G, Zhang R, Sette C, Conti M (Apr 1996). "Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene ... "Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification ... "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene. 138 (1-2): 253-6. doi: ...
Denis D, Riendeau D (February 1999). "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 ... Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN ... Osinski MT, Schrör K (August 2000). "Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 ... 6 (3): 511-9. doi:10.1097/00005344-198405000-00021. PMID 6202980. Holck M, Thorens S, Muggli R, Eigenmann R (1984). "Studies on ...
Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... phosphodiesterases. Other advantages of the unique 2'-5' linkage may be that cGAMP is able to bind multiple allelic variants of ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... "Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses". Science 23 August 2013: Vol. 341 no. 6148 pp ...
Chapter 33 in Cyclic Nucleotide Phosphodiesterases in Health and Disease, Eds Joseph A. Beavo et al. CRC Press, Dec 5, 2006 ... Hannila SS, Filbin MT (Feb 2008). "The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury ... Nov 2012). "Phosphodiesterases as therapeutic targets for Alzheimer's disease". ACS Chem Neurosci. 3 (11): 832-44. doi:10.1021/ ... Apr 2013). "Phosphodiesterase 4-targeted treatments for autoimmune diseases". BMC Med. 11 (1): 96. doi:10.1186/1741-7015-11-96 ...
Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi:10.1067/mai ... Fertel, R. and Weiss, B.: Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung" Mol. ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... 244 (20): 5763-, 5. PMID 4310608.. *^ Takeuchi M, Yanagida M (1993). "A mitotic role for a novel fission yeast protein kinase ... A major target of Akt kinases is glycogen synthase kinase-3. EC 2.7.1.37 Pelle. is a serine/threonine kinase that can ... Langan TA (1969). "Action of adenosine 3',5'-monophosphate-dependent histone kinase in vivo". J. Biol. Chem. ...
... cyclic AMP 3',5'-cyclic dAMP 3',5'-cyclic IMP 3',5'-cyclic GMP 3',5'-cyclic CMP As per Andrew T. Bender and Joseph A. Beavo, ... 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17, cyclic 3',5'-mononucleotide phosphodiesterase, PDE, cyclic 3',5'- ... monophosphate phosphodiesterase (cyclic CMP), cyclic 3',5-nucleotide monophosphate phosphodiesterase, nucleoside 3',5'-cyclic ... Kroll S, Phillips WJ, Cerione RA (March 1989). "The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the ...
PDE4 hydrolyzes cyclic adenosine monophosphate (cAMP) to inactive adenosine monophosphate (AMP). Inhibition of PDE4 blocks ... Moustafa, F; Feldman, SR (16 May 2014). "A Review of Phosphodiesterase-Inhibition and the Potential Role for Phosphodiesterase ... is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a ... "Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor" (pdf). British ...
Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific ... into AMP and GMP. These second messengers control many physiological processes. The cAMP is formed from ATP by the enzyme ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... Phosphodiesterase 5 (PDE5) is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder ...
... an effect mediated by decreased cyclic AMP-mediated phosphorylation-activation of the enzyme.[25] α2 receptors also cause ... Cashman JR, Ghirmai S (October 2009). "Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase ... decreased intracellular cyclic AMP expression which results in smooth muscle relaxation or decreased secretion.[26] TCAs ... 292 (5): R1775-81. doi:10.1152/ajpregu.00527.2006. PMID 17218444.. *^ a b Morishita S, Arita S (February 2003). "The clinical ...
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso, G.D.; ...
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. ... Catalyzes the hydrolysis of both cAMP and cGMP to 5-AMP and 5-GMP, respectively (By similarity). ... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: UniProtKB. *cyclic-nucleotide phosphodiesterase activity ... cyclic-AMP and -GMP phosphodiesterase 11AAdd BLAST. 933. Amino acid modifications. Feature key. Position(s). DescriptionActions ...
2002 Feb 15;46(3):278-86. Research Support, Non-U.S. Govt; Research Support, U.S. Govt, P.H.S. ... cyclic AMP phosphodiesterase from Escherichia coli encoded by the cpdA gene does not show any homology to either PDE class I or ... Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of enzymes that were previously divided by their primary ... Cyclic nucleotide phosphodiesterases class III: members, structure, and catalytic mechanism.. Richter W1. ...
A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability.. J. Biol. Chem. 284 32846 ... In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP ... cyclic nucleotide phosphodiesterase: biochemical and mutational analysis.. Biochemistry 44 15695-704 2005 ... Identification of the cpdA gene encoding cyclic 3,5-adenosine monophosphate phosphodiesterase in Escherichia coli.. J. Biol. ...
... cyclic-AMP phosphodiesterase activity Source: GO_Central ,p>Inferred from Biological aspect of Ancestor,/p> ,p>A type of ... cyclic AMP degradation. This protein is involved in step 1 of the subpathway that synthesizes AMP from 3,5-cyclic AMP.. ... Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.Curated. Phylogenomic databases. evolutionary ... cyclic phosphodiesterase 7BAdd BLAST. 450. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ...
... cyclic-AMP phosphodiesterase activity IBA Inferred from Biological aspect of Ancestor. more info ... cyclic GMP-inhibited phosphodiesterase B. cyclic nucleotide phosphodiesterase. phosphodiesterase 3B, cGMP-inhibited. NP_ ... PDEase_I; 35-cyclic nucleotide phosphodiesterase. pfam06532. Location:136 → 282. DUF1109; Protein of unknown function ( ... PDEase_I; 35-cyclic nucleotide phosphodiesterase. pfam06532. Location:136 → 282. DUF1109; Protein of unknown function ( ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
... cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd. J. Bacteriol. ... Cyclic nucleotides, cyclic nucleotide phosphodiesterase, and development in Myxococcus xanthus. Can. J. Microbiol. 24:1475-1484 ... Sequential changes in the cyclic nucleotide levels and cyclic phosphodiesterase activities during development of M. xanthus. ... cyclic AMP, AMP, ADP and nutrition. Proc. Natl. Acad. Sci. USA 72:518-522. ...
Their structures were determined by spectroscopic analysis and hydrolysis to be 3 beta-hydroxy-(25R)-5 alpha-spirostan-6-one ( ... laxogenin) 3-O-beta-D-glucopyranosyl-(1----4)-O-[alpha-L-arabinopyranosyl-(1- ---6)]-beta-D-gl … ... Cyclic-AMP Phosphodiesterases / antagonists & inhibitors * Carbohydrate Sequence * Hydrolysis * Magnetic Resonance Spectroscopy ... Their structures were determined by spectroscopic analysis and hydrolysis to be 3 beta-hydroxy-(25R)-5 alpha-spirostan-6-one ( ...
Cyclic AMP. 60-92-4. C10H12N5O6P. 329.2059. 329.052519653. Not Available. ... C32H62O5. 526.843. 526.459725096. Not Available. HMDB0007041. DG(14:1(9Z)/16:1(9Z)/0:0). C33H60O5. 536.8265. 536.44407503. Not ... 7732-18-5. H2O. 18.0153. 18.010564686. Not Available. HMDB0000464. Calcium. 7440-70-2. Ca. 40.078. 39.962591155. Not Available ... C31H56O5. 508.7733. 508.412774902. Not Available. HMDB0056134. DG(14:1n5/0:0/14:1n5). C31H56O5. 508.784. 508.412774903. Not ...
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3,5-GMP phosphodiesterase, cyclic guanosine 3,5- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3,5-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3,5-cyclic phosphate ...
... cyclic-AMP phosphodiesterase activity / metal ion binding. Processes. cAMP catabolic process / signal transduction / synaptic ... cyclic phosphodiesterase 7B. Synonyms. *3.1.4.53. Gene Name. PDE7B. Organism. Humans. Amino acid sequence. ,lcl,BSEQ0010437, ... a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun. 2000 May 27;272(1):186-92. [PubMed: ... Sasaki T, Kotera J, Yuasa K, Omori K: Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res ...
The enzyme is widely distributed in animal tissue and controls the level of intracellular cyclic AMP. Also acts on 3,5-cyclic ... An enzyme that catalyzes the hydrolysis of cyclic AMP to form adenosine 5-phosphate. ... Cyclic Nucleotide Phosphodiesterases, Type 1 Cyclic Nucleotide Phosphodiesterases, Type 2 Cyclic Nucleotide Phosphodiesterases ... Cyclic Nucleotide Phosphodiesterases, Type 4 Cyclic Nucleotide Phosphodiesterases, Type 5 Cyclic Nucleotide Phosphodiesterases ...
... cyclic AMP phosphodiesterase {ECO:0000256,HAMAP-Rule:MF_00905}; DE Short=cAMP phosphodiesterase {ECO:0000256,HAMAP-Rule:MF_ ... cyclic-AMP phosphodiesterase activity; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR ... cyclic AMP + H2O = AMP + H(+); CC Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:58165, ChEBI:CHEBI ... cyclic adenosine monophosphate phosphodiesterase CpdA {ECO:0000256,HAMAP-Rule:MF_00905}; DE Short=3,5- ...
... cyclic-AMP and -GMP phosphodiesterase 11A. *EC 3.1.4. *EC 3.1.4.17 ... Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp ... cAMP and cGMP cyclic nucleotide phosphodiesterase 11A. *cAMP ...
... cyclic AMP: step 1/1.. * Sequence similarities. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. ... High affinity cAMP specific and IBMX insensitive 35 cyclic phosphodiesterase 8A. *High affinity cAMP-specific and IBMX- ... May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. ... cyclic AMP degradation; AMP from 3,5- ... Weakly similar to 35 cyclic nucleotide phosphodiesterase. see ...
... cyclic AMP: step 1/1.. * Sequence similarities. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. ... cyclic AMP degradation; AMP from 3,5- ... phosphodiesterase 4A cAMP specific. *Phosphodiesterase 4A, cAMP ...
6-[3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl]-2,3,4,5-tetrahydro-5 - methylpyridazin-3-one (bemoradan) was found … ... A series of 6-benzoxazinylpyridazin-3-ones was prepared and evaluated for inhibition of cardiac phosphodiesterase (PDE) ... Cyclic-AMP Phosphodiesterases / antagonists & inhibitors * Animals * Benzoxazines * Cardiotonic Agents* * Chemical Phenomena * ... 6-Benzoxazinylpyridazin-3-ones: Potent, Long-Acting Positive Inotrope and Peripheral Vasodilator Agents J Med Chem. 1990 Jan;33 ...
... cyclic-AMP phosphodiesterase activity / cAMP binding / ion channel binding / metal ion binding ... The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family. Gene. 1993 Jul 30;129(2):239- ... Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 ... Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H: Structures of the four subfamilies of phosphodiesterase-4 ...
Cyclic AMP. A Possible Role of the Pancreatic α1 and α2-Cells as Local Regulators of Insulin Secretion. Intestinal Hormones and ... Biochemical, Pharmacological, and Physiological Aspects of the Adenylcyclase-Phosphodiesterase System in the Pancreatic ß-Cells ... Feedback Regulation of Insulin Secretion by Insulin: Role of 3,5- ...
... cyclic-AMP) uses effector proteins to influence cell function and fate.1 The synthesis and degradation of cyclic-AMP are ... it was unclear how cyclic-AMP inhibited PI3K activity. Further investigation showed that cyclic-AMP, in a PDE4B-dependent ... In nonneoplastic models, cyclic-AMP is known to attenuate vessel development.28⇓⇓-31 To address the contribution of PDE4B ... Here, we review a decade-long exploration of the contribution of cyclic-AMP and PDE4 to the pathogenesis of B-cell lymphoma,5⇓⇓ ...
It is enzymatically produced by diadenylate cyclase and cleaved by c-di-AMP phosphodiesterase. c-di-AMP is believed to be ... It is enzymatically produced by diadenylate cyclase and cleaved by c-di-AMP phosphodiesterase. c-di-AMP is believed to be ... two distinct Streptococcus mutans phosphodiesterases involved in the pathway producing AMP from c-di-AMP, were investigated. ... two distinct Streptococcus mutans phosphodiesterases involved in the pathway producing AMP from c-di-AMP, were investigated. ...
... cyclic-AMP phosphodiesterase activity *[MF] cGMP binding *[MF] calcium- and calmodulin-regulated 3,5-cyclic-GMP ... MF] calmodulin-dependent cyclic-nucleotide phosphodiesterase activity *[MF] hydrolase activity *[MF] metal ion binding ...
Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of ... cyclic-AMP phosphodiesterase involved in cAMP-mediated signaling; cellular location unknown. View computational annotations ... PhosphoDiEsterase 1 Comparative Info. Integrated model organism details available at the Alliance of Genome Resources website ... the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation 1 2 3 4 5 Name Description. ...
High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell ... cyclic-AMP phosphodiesterase involved in cAMP-mediated signaling; localizes to nucleus and cytoplasm in high-throughput studies ... PhosphoDiEsterase 5 Comparative Info. Integrated model organism details available at the Alliance of Genome Resources website ... from extracellular cAMP, contains readthrough motif surrounding termination codon 1 2 3 4 Name Description. ...
  • In addition, the availability of atomic coordinates for several purple acid phosphatases and related proteins allowed the generation of a three-dimensional model for class III cyclic nucleotide phosphodiesterases. (nih.gov)
  • A tBLASTn search of the Myxococcus xanthus genome database at The Institute for Genomic Research (TIGR) identified three genes ( pdeA , pdeB , and pdeC ) that encode proteins homologous to 3′,5′-cyclic nucleotide phosphodiesterase. (asm.org)
  • Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. (genecards.org)
  • AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. (proteopedia.org)
  • Results: Three proteins were identified, of which the proinflammatory chemokine CC chemokine ligand 3 (CCL3) and cytokine TNF-a were downregulated and the antiinflammatory cytokine interleukin-1 receptor antagonist was upregulated. (thefreelibrary.com)
  • sup][5] The cAMP effectors protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac) are thought to mediate these inhibitory effects. (thefreelibrary.com)
  • Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus activating the catalytic units and enabling them to phosphorylate substrate proteins. (wikidoc.org)
  • Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function. (ac.be)
  • 1971). The specific distribution of cyclic AMP in various brain regions reflects the relative activities of the synthetic and degradative enzymes, adenyl cyclase, and phosphodiesterase. (springer.com)
  • In solution, the C 1a and C 2a domains can form heterodimers with each other, either in the same or different enzymes, or they can form homodimers with their identical units on different enzymes [3] . (proteopedia.org)
  • Structure of dog adenylyl cyclase 5 (grey), rat adenylyl cyclase 2 (green), bovine guanine nucleotide-binding protein subunit α (pink) complex with ADP derivative (stick model), GDP derivative (stick model), methylpiperazinoforskolin, Ca+2, Mg+2 and Cl- ions (PDB code 3maa ). (proteopedia.org)
  • A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. (hmdb.ca)
  • cAMP coordinates the regulation of these cellular responses by activating cAMP-dependent protein kinases (PKAs) ( 4 ), specific guanine nucleotide exchange factors (EPACs) ( 5 ), and cyclic nucleotide-gated ion channels ( 6 ). (pnas.org)
  • In the current study, the biochemical and biological roles of GdpP (SMU_2140c) and DhhP (SMU_1297), two distinct Streptococcus mutans phosphodiesterases involved in the pathway producing AMP from c-di-AMP, were investigated. (frontiersin.org)
  • less thanbrgreater than less thanbrgreater thanThe present study aimed to investigate by means of immunohistochemistry in the human prostate the expression and distribution of key mediators of the NO pathway, namely cyclic GMP, the neuronal nitric oxide synthase (nNOS), and cyclic GMP-binding protein kinases type I (cGKI alpha, cGKI), in relation to PDE5, protein kinase A (cAK), and the vasoactive intestinal polypeptide (VIP). (diva-portal.org)
  • May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. (abcam.com)
  • This compound enhances the magnitude of accumulations of cyclic 3',5'-AMP elicited by norepinephrine, isoproterenol, histamine, and adenosine in rat cerebral cortical slices and by veratridine in rat cerebellar slices and, in addition, increases basal levels of cyclic AMP in both cortical and cerebellar slices. (aspetjournals.org)
  • Increases in intracellular levels of cyclic AMP in brain slices elicited by ZK 62711 do not appear to involve enhanced "release" of adenosine, since both basal and norepinephrine-elicited accumulations of cyclic AMP are increased by ZK 62711 in the presence of exogenous adenosine deaminase. (aspetjournals.org)
  • Fluid secretion by tubules dosed repeatedly with Acheta-DP returns to near basal levels after 3-5 h. (biologists.org)
  • I Ca,L amplitude increased twice slower than cAMP at the membrane, and the current remained elevated for ≈5 minutes after cAMP had already returned to basal level, indicating that cAMP changes are not rate-limiting in channel phosphorylation/dephosphorylation. (ahajournals.org)
  • To evaluate the time course of the cAMP changes in the different compartments, brief (15 seconds) pulses of isoprenaline (100 nmol/L) were applied to adult rat ventricular myocytes (ARVMs) while monitoring cAMP changes beneath the membrane using engineered cyclic nucleotide-gated channels and within the cytosol with the fluorescence resonance energy transfer-based sensor, Epac2-camps. (ahajournals.org)
  • Indeed, the presence of subcellular compartments with different cAMP concentrations, also called cAMP microdomains, are inferred from L-type Ca 2+ channel current ( I Ca,L ) measurements in response to local β-AR stimulation in cardiomyocytes 5 and by direct monitoring of cAMP using fluorescence resonance energy transfer (FRET)-based sensors 6,7 or cyclic nucleotide-gated (CNG) channels. (ahajournals.org)
  • Recent research may indicate that cAMP affects the function of higher order thinking in the prefrontal cortex through its regulation of ion channels called hyperpolarization-activated cyclic nucleotide-gated channels (HCN). (wikidoc.org)
  • Data indicate that genome-wide significant associations were found both at age 6 and 14 with single nucleotide polymorphisms (SNPs) on chromosome 11p15 in phosphodiesterase 3B, cGMP-inhibited protein PDE3B/cytochrome P-450 CYP2R1 genes. (nih.gov)
  • AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. (genecards.org)
  • CDNs including c-di-AMP bind the cytosolic DNA sensor STING (stimulator of interferon genes) and induce the production of type I interferons (IFNs). (invivogen.com)
  • This list of 582 genes contains 12 proteases and 3 antiproteases. (biomedcentral.com)
  • Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. (proteopedia.org)
  • Cohn ML (1975) Cyclic AMP, thryrotropin-releasing factor and somatostatin: key factors in the regulation of the duration of narcosis. (springer.com)
  • Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells. (ac.be)
  • Cohn ML, Yamaoka H, Taylor FH, Kraynack B (1973) Action of intracerebroventricular dibutyryl cyclic AMP on amobarbital anaesthesia in rats. (springer.com)
  • ABHD15 associates with and stabilizes phosphodiesterase 3B (PDE3B). (nih.gov)
  • 7. These findings, in a clonal insulin secreting cell line, are consistent with an important role for PDE3B in regulating the pool of cyclic AMP relevant to the modulation of glucose-induced insulin secretion. (strath.ac.uk)
  • less thanbrgreater than less thanbrgreater thanIn the smooth muscle portion of the transition zone, immunosignals specific for the PDE5 were found co-localized with cyclic GMP, cGKI alpha, and cGKI, as well as with the cyclic cAMP-binding protein kinase A. Smooth muscle bundles were seen innervated by slender varicose nerves characterized by the expression of nNOS. (diva-portal.org)
  • Intracellular cyclic AMP (cAMP) levels of pdeA or pdeB mutant cells under these stressful conditions were about 1.3-fold to 2.0-fold higher than those of wild-type cells. (asm.org)
  • A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: implication for vascular control. (nih.gov)
  • Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis. (bioportfolio.com)
  • X-ray crystal structure of pactamide G () sets an example for resolving the absolute configuration of 5/5/6 type PoTeMs. (bioportfolio.com)
  • When it was found that the antibiotic rapamycin was a potent inhibitor of the proliferation of virtually every eukaryotic cell type examined (e.g., fungi, T cells, and tumor cells) [ 1 , 2 , 3 ], it became clear that the molecular target of rapamycin must be highly conserved and its function critical for cell survival. (mdpi.com)
  • Due to its linear conformation, 5'-pApA is intended to serve as a negative control for c-di-AMP in type I IFN induction assays. (invivogen.com)
  • The inability of c-di-AMP Control to induce type I interferon (IFN) has been confirmed in THP1-Blue™ ISG cells. (invivogen.com)