3',5'-Cyclic-AMP Phosphodiesterases: Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Cyclic Nucleotide Phosphodiesterases, Type 4: A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.Cyclic Nucleotide Phosphodiesterases, Type 3: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.Phosphoric Diester Hydrolases: A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.Cyclic Nucleotide Phosphodiesterases, Type 1: A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.Cyclic Nucleotide Phosphodiesterases, Type 2: A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.3',5'-Cyclic-GMP Phosphodiesterases: Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.Phosphodiesterase Inhibitors: Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.2',3'-Cyclic-Nucleotide Phosphodiesterases: Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.Cyclic Nucleotide Phosphodiesterases, Type 5: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.Rolipram: A phosphodiesterase 4 inhibitor with antidepressant properties.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Cyclic Nucleotide Phosphodiesterases, Type 7: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own tissue localization. The isoforms are encoded by at least two genes and are a product of multiple alternative splicing of their mRNAs.1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASESNucleotides, CyclicPurinones
*  PDE4B
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic ... The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a ... "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family". Gene. 129 (2): 239-47. doi: ... Moustafa F, Feldman SR (May 2014). "A review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4- ...
*  Cyclic nucleotide
cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ...
*  PDE4C
... phosphodiesterase E1 dunce homolog, Drosophila)". Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for ... Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene ... cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene. PDE4C is predominantly found in ... 2001). "Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H] ...
*  3',5'-cyclic-AMP phosphodiesterase
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso, G.D.; ...
*  PDE11A
... cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclic ... Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ...
*  3',5'-cyclic-GMP phosphodiesterase
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate ...
*  Phosphodiesterase 4
... cyclic-AMP phosphodiesterase Phosphodiesterase PDE4 inhibitor. ... At least four types of the enzyme phosphodiesterase 4 (PDE4) ...
*  8-Bromoadenosine 3',5'-cyclic monophosphate
... and it is long-acting because it is resistant to degradation by cyclic AMP phosphodiesterase. 8-Bromoguanosine 3',5'-cyclic ... is a brominated derivative of cyclic adenosine monophosphate (cAMP). 8-Br-cAMP is an activator of cyclic AMP-dependent protein ... cyclic monophosphate at Sigma-Aldrich 8-Bromo Cyclic Adenosine Monophosphate at PubChem. ...
*  List of EC numbers (EC 3)
... cyclic-AMP phosphodiesterase EC 3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D EC 3.1.5.1: dGTPase EC ... CMP-N-acylneuraminate phosphodiesterase EC 3.1.4.41: sphingomyelin phosphodiesterase D EC 3.1.4.42: glycerol-1,2-cyclic- ... glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase EC 3.1.4.52: cyclic-guanylate-specific phosphodiesterase EC 3.1.4.53 ... cyclic-nucleotide phosphodiesterase EC 3.1.4.18: now EC 3.1.16.1 EC 3.1.4.19: now EC 3.1.13.3 EC 3.1.4.20: now EC 3.1.13.1 EC ...
*  2',3'-Cyclic-nucleotide 3'-phosphodiesterase
"Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". The ... Helfman DM, Kuo JF (Jan 1982). "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- ... Nov 2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase ... selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium". ...
*  Phosphodiesterase
"Ontogenic development of a phosphodiesterase activator and the multiple forms of cyclic AMP phosphodiesterase of rat brain". ... A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ... as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases ...
*  Cyclic adenosine monophosphate
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. cAMP is a second messenger, used for intracellular ... such as cyclic adenosine monophosphate, cyclic AMP). Cyclic AMP is synthesized from ATP by adenylate cyclase located on the ... Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in ... In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase). PKA is normally ...
*  PDE4D
Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current ... Némoz G, Zhang R, Sette C, Conti M (Apr 1996). "Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene ... "Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification ... "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene. 138 (1-2): 253-6. doi: ...
*  Quazinone
Denis D, Riendeau D (February 1999). "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 ... Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN ... Osinski MT, Schrör K (August 2000). "Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 ... 6 (3): 511-9. doi:10.1097/00005344-198405000-00021. PMID 6202980. Holck M, Thorens S, Muggli R, Eigenmann R (1984). "Studies on ...
*  CGAS-STING cytosolic DNA sensing pathway
Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... phosphodiesterases. Other advantages of the unique 2'-5' linkage may be that cGAMP is able to bind multiple allelic variants of ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... "Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses". Science 23 August 2013: Vol. 341 no. 6148 pp ...
*  Rolipram
Chapter 33 in Cyclic Nucleotide Phosphodiesterases in Health and Disease, Eds Joseph A. Beavo et al. CRC Press, Dec 5, 2006 ... Hannila SS, Filbin MT (Feb 2008). "The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury ... Nov 2012). "Phosphodiesterases as therapeutic targets for Alzheimer's disease". ACS Chem Neurosci. 3 (11): 832-44. doi:10.1021/ ... Apr 2013). "Phosphodiesterase 4-targeted treatments for autoimmune diseases". BMC Med. 11 (1): 96. doi:10.1186/1741-7015-11-96 ...
*  Phosphodiesterase inhibitor
Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi:10.1067/mai ... Fertel, R. and Weiss, B.: Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung" Mol. ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ...
*  Cyclic nucleotide phosphodiesterase
... cyclic AMP 3',5'-cyclic dAMP 3',5'-cyclic IMP 3',5'-cyclic GMP 3',5'-cyclic CMP As per Andrew T. Bender and Joseph A. Beavo, ... 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17, cyclic 3',5'-mononucleotide phosphodiesterase, PDE, cyclic 3',5'- ... monophosphate phosphodiesterase (cyclic CMP), cyclic 3',5-nucleotide monophosphate phosphodiesterase, nucleoside 3',5'-cyclic ... Kroll S, Phillips WJ, Cerione RA (March 1989). "The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the ...
*  Phosphodiesterase-4 inhibitor
PDE4 hydrolyzes cyclic adenosine monophosphate (cAMP) to inactive adenosine monophosphate (AMP). Inhibition of PDE4 blocks ... Moustafa, F; Feldman, SR (16 May 2014). "A Review of Phosphodiesterase-Inhibition and the Potential Role for Phosphodiesterase ... is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a ... "Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor" (pdf). British ...
*  Discovery and development of phosphodiesterase 5 inhibitors
Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific ... into AMP and GMP. These second messengers control many physiological processes. The cAMP is formed from ATP by the enzyme ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... Phosphodiesterase 5 (PDE5) is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder ...
*  PRKAR2A
Dransfield DT, Bradford AJ, Smith J, Martin M, Roy C, Mangeat PH, Goldenring JR (Jan 1997). "Ezrin is a cyclic AMP-dependent ... "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". The EMBO Journal. 20 (8): 1921-30. doi: ... Beebe SJ, Salomonsky P, Holroyd C, Becker D (Dec 1993). "Differential expression of cyclic AMP-dependent protein kinase ... "Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and ...
*  Olfactory receptor neuron
The activated OR in turn activates the intracellular G-protein, GOLF (GNAL), adenylate cyclase and production of cyclic AMP ( ... CaMKII will also activate phosphodiesterase, which will then hydrolyze cAMP. The effect of this negative feedback response ... "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons". Proc ... 5 (3): 243-66. PMID 9663551. Schacter, Daniel L. (2014). Psychology. p. 167. ISBN 1464106037. Cunningham, A.M.; Manis, P.B.; ...
*  Phosphodiester bond
... for instance a bond in a molecule of cyclic AMP or cyclic GMP. An enzyme that plays an important role in the repair of ... Phosphodiesterase Phosphodiesterase inhibitor DNA replication, DNA, ATP Teichoic acid, DNase I PDE5 Nick (DNA) Even prions, the ... A phosphodiesterase is an enzyme that catalyzes the hydrolysis of phosphodiester bonds, ... phosphodiesterase. During the replication of DNA, there is a hole between the phosphates in the backbone left by DNA polymerase ...
*  Histamine H1 receptor
Holden CA, Chan SC, Norris S, Hanifin JM (Oct 1987). "Histamine induced elevation of cyclic AMP phosphodiesterase activity in ... affects intracellular messaging including downstream signaling accomplished through various intermediaries such as cyclic AMP, ... cyclic GMP, calcium, and nuclear factor kappa B (NF-κB), a ubiquitous transcription factor thought to play an important role in ... 109 (3): 524-31. doi:10.1067/mai.2002.121944. PMID 11898002. Idzko M, la Sala A, Ferrari D, Panther E, Herouy Y, Dichmann S, ...
*  Anagrelide
Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A (February 1987). "Inhibitors of cyclic AMP phosphodiesterase. 1. ... The exact mechanism of action is unclear, although it is known to be a phosphodiesterase inhibitor. It is a potent (IC50 = 36nM ... Phosphodiesterase inhibitor with antiplatelet activity. Condensation of benzyl chloride 1 with ethyl ester of glycine gives ... inhibitor of phosphodiesterase-II.[citation needed] It inhibits PDE-3 and phospholipase A2. ...
*  PDE4A
... cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]" (pdf). ... "The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both ... rolipram-sensitive cyclic AMP phosphodiesterase" (pdf). Molecular and Cellular Biology. 10 (6): 2678-86. doi:10.1128/MCB.10.6. ... cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)". Cellular Signalling. 6 (7): 793-812. doi:10.1016/0898-6568(94)00039-5. ...
*  Papaverine
... but an inhibition of the enzyme phosphodiesterase causing elevation of cyclic AMP[clarification needed] levels is significant. ... Papaverine has also been demonstrated to be a selective phosphodiesterase inhibitor for the PDE10A subtype found mainly in the ... August 2006). "Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis". ... Hebb AL, Robertson HA, Denovan-Wright EM (May 2008). "Phosphodiesterase 10A inhibition is associated with locomotor and ...
Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase...  Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase...
This action can be detected by attenuating the degradation of cyclic AMP by using inhibitors of cyclic AMP phosphodiesterase. ... adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP ... adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP ... adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP ...
more infohttp://www.biochemj.org/content/249/2/543
3,5-cyclic-AMP phosphodiesterase - Wikipedia  3',5'-cyclic-AMP phosphodiesterase - Wikipedia
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso, G.D.; ...
more infohttps://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase
Pde11a - Dual 3,5-cyclic-AMP and -GMP phosphodiesterase 11A - Mus musculus (Mouse) - Pde11a gene & protein  Pde11a - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Mus musculus (Mouse) - Pde11a gene & protein
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. ... Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity). ... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: UniProtKB. *cyclic-nucleotide phosphodiesterase activity ... cyclic-AMP and -GMP phosphodiesterase 11AAdd BLAST. 933. Amino acid modifications. Feature key. Position(s). DescriptionActions ...
more infohttps://www.uniprot.org/uniprot/P0C1Q2
3,5 Cyclic nucleotide phosphodiesterases class III: members, structure, and catalytic mechanism.  - PubMed - NCBI  3',5' Cyclic nucleotide phosphodiesterases class III: members, structure, and catalytic mechanism. - PubMed - NCBI
2002 Feb 15;46(3):278-86. Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. ... cyclic AMP phosphodiesterase from Escherichia coli encoded by the cpdA gene does not show any homology to either PDE class I or ... Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of enzymes that were previously divided by their primary ... Cyclic nucleotide phosphodiesterases class III: members, structure, and catalytic mechanism.. Richter W1. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/11835503?dopt=Abstract
3,5-cyclic adenosine monophosphate phosphodiesterase CpdA (IPR026575) | InterPro | EMBL-EBI  3,5-cyclic adenosine monophosphate phosphodiesterase CpdA (IPR026575) | InterPro | EMBL-EBI
A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability.. J. Biol. Chem. 284 32846 ... In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP ... cyclic nucleotide phosphodiesterase: biochemical and mutational analysis.. Biochemistry 44 15695-704 2005 ... Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli.. J. Biol. ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR026575
Pde8b - High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8B - Mus musculus (Mouse) - Pde8b gene ...  Pde8b - High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B - Mus musculus (Mouse) - Pde8b gene ...
... cyclic-AMP phosphodiesterase activity Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the ... cyclic AMP degradation. This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.. ... Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.Curated. Phylogenomic databases. evolutionary ... cyclic phosphodiesterase 8BAdd BLAST. 865. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ...
more infohttps://www.uniprot.org/uniprot/E9Q4S1
SWISSPROT: C5B6Y1 EDWI9  SWISSPROT: C5B6Y1 EDWI9
... cyclic AMP phosphodiesterase {ECO:0000256,HAMAP-Rule:MF_00905}; DE Short=cAMP phosphodiesterase {ECO:0000256,HAMAP-Rule:MF_ ... cyclic-AMP phosphodiesterase activity; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR ... cyclic AMP + H2O = AMP + H(+); CC Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:58165, ChEBI:CHEBI ... cyclic adenosine monophosphate phosphodiesterase CpdA {ECO:0000256,HAMAP-Rule:MF_00905}; DE Short=3',5'- ...
more infohttp://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-ac?query=C5B6Y1&db=SWISSPROT
PDE4D phosphodiesterase 4D [Homo sapiens (human)] - Gene - NCBI  PDE4D phosphodiesterase 4D [Homo sapiens (human)] - Gene - NCBI
Title: The cyclic AMP phosphodiesterase 4D5 (PDE4D5)/receptor for activated C-kinase 1 (RACK1) signalling complex as a sensor ... cyclic phosphodiesterase 4D. Names. cAMP-specific phosphodiesterase PDE4D6. phosphodiesterase 4D, cAMP-specific ( ... Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in ... cyclic phosphodiesterase 4D isoform X2. Conserved Domains (1) summary. pfam00233. Location:400 → 637. PDEase_I; 3'5'-cyclic ...
more infohttps://www.ncbi.nlm.nih.gov/gene/5144
Gene Info  Gene Info
... cyclic-AMP phosphodiesterase activity *[MF] cGMP binding *[MF] calcium- and calmodulin-regulated 3',5'-cyclic-GMP ... MF] calmodulin-dependent cyclic-nucleotide phosphodiesterase activity *[MF] hydrolase activity *[MF] metal ion binding ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=40678&LLNO=18573
PDE11A Antibody (NBP1-85919): Novus Biologicals  PDE11A Antibody (NBP1-85919): Novus Biologicals
... cyclic-AMP and -GMP phosphodiesterase 11A. *EC 3.1.4. *EC 3.1.4.17 ... Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp ... cAMP and cGMP cyclic nucleotide phosphodiesterase 11A. *cAMP ...
more infohttps://www.novusbio.com/products/pde11a-antibody_nbp1-85919
PDE4C Gene - GeneCards | PDE4C Protein | PDE4C Antibody  PDE4C Gene - GeneCards | PDE4C Protein | PDE4C Antibody
Phosphodiesterase 4C, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE ... AMP from 3,5-cyclic AMP: step 1/1.. *Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1. ... Phosphodiesterase 4C, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E1) 2 * Phosphodiesterase 4C, CAMP-Specific ( ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=PDE4C
Recombinant Human PDE4D 293 Cell Lysate PDE4D-3350HCL - Creative BioMart  Recombinant Human PDE4D 293 Cell Lysate PDE4D-3350HCL - Creative BioMart
... phosphodiesterase E3 dunce homolog (Drosophila); cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific ( ... Antigen standard for phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) (PDE4D), transcript ... PDE4D; phosphodiesterase 4D, cAMP-specific; DPDE3, phosphodiesterase 4D, cAMP specific (dunce (Drosophila) homolog ... phosphodiesterase E3 dunce homolog, Drosophila); DPDE3; PDE43; STRK1; HSPDE4D; PDE4DN2; FLJ97311; DKFZp686M11213;. ...
more infohttps://www.creativebiomart.net/description_405016_318.htm
The effect of Thd, IMiDs and SelCIDs on bFGF and VEGF-i | Open-i  The effect of Thd, IMiDs and SelCIDs on bFGF and VEGF-i | Open-i
Cyclic-AMP Phosphodiesterases/antagonists & inhibitors. *Animals. *Cell Division/drug effects. *Cell Movement/drug effects ... Mentions: In the proliferation studies, we found that SelCID-2 and 3 inhibited bFGF and VEGF-induced proliferation (P,0.05) of ... Mentions: In the proliferation studies, we found that SelCID-2 and 3 inhibited bFGF and VEGF-induced proliferation (P,0.05) of ... getmorefigures.php?uid=PMC2376196&req=5. .flowplayer { width: px; height: px; } fig4: The effect of Thd, IMiDs and SelCIDs on ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2376196_87-6600607f4&req=4
Affi-Gel® Blue Gel | Process Separations | Bio-Rad  Affi-Gel® Blue Gel | Process Separations | Bio-Rad
ATP:AMP phosphotransferase. Bovine heart. 0.4-2.0 M NaCl. Calmodulin-dependent cyclic. nucleotide phosphodiesterase. Bovine ... 5 mg/ml. 2-10. 1,000 psi (70 bar). Endotoxin removal. Affi-Gel Boronate. Polyacrylamide gel. Boronate 1.05 ± 0.15. cis-diols. ... 3',5' cyclic AMP phosphodiesterase. Dictyostelium discoideum. 0.18 M NaCl. 3'-PGA diesterase. Yeast. 0.6 M KCl in 50 mM Tris- ... 5-methyl-L-tetrahydrofolate reductase. Bovine liver. 0.4-3.0 M KCl. Acylation stimulating protein. Human plasma. 3 M NaCl, 0.02 ...
more infohttp://www.bio-rad.com/en-ca/product/ready-use-affinity-media/affi-gel-blue-gel?pcp_loc=lnav
anti-PDE7A antibody | Rabbit PDE7A Polyclonal Antibody-NP 001229247.1  anti-PDE7A antibody | Rabbit PDE7A Polyclonal Antibody-NP 001229247.1
... cyclic-AMP phosphodiesterase activity; metal ion binding. Biological Process: cAMP catabolic process; signal transduction ... cyclic phosphodiesterase 7A; TM22; phosphodiesterase isozyme 7 UniProt Protein Name High affinity cAMP-specific 3',5'-cyclic ... Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by ... The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE ...
more infohttps://www.mybiosource.com/prods/Antibody/Polyclonal/PDE7A/datasheet.php?products_id=240106
Contribution of the Cyclic Nucleotide Phosphodiesterases PdeA and PdeB to Adaptation of Myxococcus xanthus Cells to Osmotic or...  Contribution of the Cyclic Nucleotide Phosphodiesterases PdeA and PdeB to Adaptation of Myxococcus xanthus Cells to Osmotic or...
... cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd. J. Bacteriol. ... Cyclic nucleotides, cyclic nucleotide phosphodiesterase, and development in Myxococcus xanthus. Can. J. Microbiol. 24:1475-1484 ... Sequential changes in the cyclic nucleotide levels and cyclic phosphodiesterase activities during development of M. xanthus. ... cyclic AMP, AMP, ADP and nutrition. Proc. Natl. Acad. Sci. USA 72:518-522. ...
more infohttps://jb.asm.org/content/188/2/823?ijkey=4090297e2473c64048b1de76804c42d97a5c50b5&keytype2=tf_ipsecsha
3,5-cyclic-GMP phosphodiesterase - Wikipedia  3',5'-cyclic-GMP phosphodiesterase - Wikipedia
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Molecular ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate ...
more infohttps://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase
A Mutation in the sap Operon Attenuates Survival of Nontypeable Haemophilus influenzae in a Chinchilla Model of Otitis Media |...  A Mutation in the sap Operon Attenuates Survival of Nontypeable Haemophilus influenzae in a Chinchilla Model of Otitis Media |...
... cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd. J. Bacteriol. ... cyclic AMP (Sigma-Aldrich) for 30 min at 37°C (8, 39). Transformants were selected on chocolate agar supplemented with 20 μg of ... 3.↵. Bakaletz, L. O., R. L. Daniels, and D. J. Lim. 1993. Modeling adenovirus type 1-induced otitis media in the chinchilla: ... 5.↵. Bakaletz, L. O., B. J. Kennedy, L. A. Novotny, G. Duquesne, J. Cohen, and Y. Lobet. 1999. Protection against development ...
more infohttps://iai.asm.org/content/73/1/599?ijkey=1ed404a2071b7e9bf08f7ad7d3c90033f47b9109&keytype2=tf_ipsecsha
Demonstration of Type IV Pilus Expression and a Twitching Phenotype by Haemophilus influenzae | Infection and Immunity  Demonstration of Type IV Pilus Expression and a Twitching Phenotype by Haemophilus influenzae | Infection and Immunity
... cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd. J. Bacteriol. ... and mutant constructions were performed by transformation with linear DNA using a modified M-IV method in which cyclic AMP was ... 3). The pilA genes of all isolates encoded a 12-residue leader peptide that is largely invariant, save a Q-to-L substitution at ... 3. ClustalW alignment of the pilA gene products from 11 NTHI isolates and strain Rd. Arrowheads indicate the locations of four ...
more infohttps://iai.asm.org/content/73/3/1635?ijkey=77ae6ef8695a5be4ab682622bcf679d66aae5e84&keytype2=tf_ipsecsha
SCOPe 2.07: Structural Classification of Proteins - extended  SCOPe 2.07: Structural Classification of Proteins - extended
Cyclic-AMP Phosphodiesterases, Cyclic nucleotide, phosphodiesterases, HYDROLASE-HYDROLASE INHIBITOR complex. Deposited on 2011- ... cyclic phosphodiesterase 4D. Species: Homo sapiens [TaxId:9606]. Gene: PDE4D. Database cross-references and differences (RAF- ... cyclic phosphodiesterase 4D. Species: Homo sapiens [TaxId:9606]. Gene: PDE4D. Database cross-references and differences (RAF- ... cyclic phosphodiesterase 4D. Species: Homo sapiens [TaxId:9606]. Gene: PDE4D. Database cross-references and differences (RAF- ...
more infohttp://scop.berkeley.edu/pdb/code=3v9b
  • Furthermore, the known biochemical properties of the bacterial phosphodiesterase encoded by the cpdA gene, such as the requirement of iron ions and a reductant for maintaining its catalytic activity, support this hypothesis developed by computational analysis. (nih.gov)
  • Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function. (ac.be)
  • Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). (creativebiomart.net)
  • Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells. (ac.be)
  • Phosphodiesterase 7A, a cAMP-specific phosphodiesterase, has been shown to affect memory, T-cell functioning and emesis and has been implicated in depression. (mybiosource.com)
  • We also report that an M. xanthus CbpB containing two cyclic AMP (cAMP)-binding domains is involved in osmotic and temperature tolerance ( 11 ). (asm.org)
  • The cellular concentration of cAMP in M. xanthus increases rapidly during starvation- and glycerol-induced development ( 5 , 22 ). (asm.org)
  • Elevated cAMP-phosphodiesterase in atopic disease: Cause or effect? (elsevier.com)
  • To evaluate the time course of the cAMP changes in the different compartments, brief (15 seconds) pulses of isoprenaline (100 nmol/L) were applied to adult rat ventricular myocytes (ARVMs) while monitoring cAMP changes beneath the membrane using engineered cyclic nucleotide-gated channels and within the cytosol with the fluorescence resonance energy transfer-based sensor, Epac2-camps. (ahajournals.org)
  • I Ca,L amplitude increased twice slower than cAMP at the membrane, and the current remained elevated for ≈5 minutes after cAMP had already returned to basal level, indicating that cAMP changes are not rate-limiting in channel phosphorylation/dephosphorylation. (ahajournals.org)
  • Indeed, the presence of subcellular compartments with different cAMP concentrations, also called cAMP microdomains, are inferred from L-type Ca 2+ channel current ( I Ca,L ) measurements in response to local β-AR stimulation in cardiomyocytes 5 and by direct monitoring of cAMP using fluorescence resonance energy transfer (FRET)-based sensors 6,7 or cyclic nucleotide-gated (CNG) channels. (ahajournals.org)
  • Human rolipram-sebsitive, cAMP-specific phosphodiesterase (PDE2) mRNA, complete cds. (embl.de)
  • Relationship of phosphodiesterase 4D (PDE4D) gene polymorphisms with risk of ischemic stroke: a hospital based case-control study. (nih.gov)
  • TT genotype of SNP87 in PDE4D was associated with an increased risk for 3-month unfavorable outcome after total ischemic stroke, as well as stroke due to large-artery atherosclerosis and small-artery occlusion, in a Chinese population. (nih.gov)
  • Structural identification of the myo-inositol 1,4,5-trisphosphate-binding domain in rat brain inositol 1,4,5-trisphosphate 3-kinase. (ac.be)
  • Indeed, ever since the authentic target of rapamycin (TOR) was first discovered using an elegant genetic approach in budding yeast ( Saccharomyces cerevisiae ) [ 4 , 5 ], TOR has emerged as a universal, centrally important sensor, integrator, and controller of eukaryotic cell growth [ 6 , 7 ]. (mdpi.com)
  • log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). (uth.edu)
  • This list of 582 genes contains 12 proteases and 3 antiproteases. (beds.ac.uk)
  • Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues. (ac.be)