Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.
A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.
Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
A phosphodiesterase 4 inhibitor with antidepressant properties.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own tissue localization. The isoforms are encoded by at least two genes and are a product of multiple alternative splicing of their mRNAs.
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
... cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclic ... Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ...
cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ...
Winchurch, R., Hait, W. and Weiss, B.: Cyclic AMP phosphodiesterase activity of murine T and B lymphocytes. Cell. Immunol. 41: ... PMID 4370207 7. Uzunov, P., Shein, H.M. and Weiss, B.: Cyclic AMP phosphodiesterase in cloned astrocytoma cells: norepinephrine ... Strada, S.J. and Weiss, B.: Increased response to catecholamines of the cyclic AMP system of rat pineal gland induced by ... He is best known for his work with cyclic nucleotide phosphodiesterases. He was the first to propose, based on his experimental ...
"Ontogenetic development of a phosphodiesterase activator and the multiple forms of cyclic AMP phosphodiesterase of rat brain". ... A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ... as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases ...
... cyclic-AMP phosphodiesterase Phosphodiesterase (PDE) PDE4 inhibitor This set index page lists chemical compounds articles ... At least four types of the enzyme phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'- ...
Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi:10.1067/mai ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ... Fertel R, Weiss B (1976). "Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung". Mol. ...
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Portal: ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3′,5′-GMP phosphodiesterase, cyclic guanosine 3′,5′- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3′,5′-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) catalyzes the reaction guanosine 3′,5′-cyclic phosphate + H2O ⇌ {\displaystyle \ ...
... and it is long-acting because it is resistant to degradation by cyclic AMP phosphodiesterase. 8-Bromoguanosine 3',5'-cyclic ... is a brominated derivative of cyclic adenosine monophosphate (cAMP). 8-Br-cAMP is an activator of cyclic AMP-dependent protein ... cyclic monophosphate at Sigma-Aldrich 8-Bromo Cyclic Adenosine Monophosphate at PubChem (Articles without InChI source, ...
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP+phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.1.4) ... Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso GD, ...
Denis D, Riendeau D (February 1999). "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 ... Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN ... Osinski MT, Schrör K (August 2000). "Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 ... 367 (2-3): 343-50. doi:10.1016/S0014-2999(98)00987-X. PMID 10079010. Media related to Quazinone at Wikimedia Commons (Drugs not ...
Chapter 33 in Cyclic Nucleotide Phosphodiesterases in Health and Disease, Eds Joseph A. Beavo et al. CRC Press, Dec 5, 2006 ... Hannila SS, Filbin MT (Feb 2008). "The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury ... Nov 2012). "Phosphodiesterases as therapeutic targets for Alzheimer's disease". ACS Chem Neurosci. 3 (11): 832-44. doi:10.1021/ ... Apr 2013). "Phosphodiesterase 4-targeted treatments for autoimmune diseases". BMC Med. 11 (1): 96. doi:10.1186/1741-7015-11-96 ...
Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... phosphodiesterases. Other advantages of the unique 2'-5' linkage may be that cGAMP is able to bind multiple allelic variants of ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... specifically by the cyclic-GMP-AMP synthase (cGAS). Upon DNA recognition, cGAS dimerizes and stimulates the formation of cyclic ...
PDE4 hydrolyzes cyclic adenosine monophosphate (cAMP) to inactive adenosine monophosphate (AMP). Inhibition of PDE4 blocks ... Moustafa, F; Feldman, SR (16 May 2014). "A Review of Phosphodiesterase-Inhibition and the Potential Role for Phosphodiesterase ... is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a ... "Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor". British Journal of ...
... cyclic AMP 3′,5′-cyclic dAMP 3′,5′-cyclic IMP 3′,5′-cyclic GMP 3′,5′-cyclic CMP There are 11 distinct phosphodiesterase ... cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a ... monophosphate phosphodiesterase (cyclic CMP), cyclic 3′,5-nucleotide monophosphate phosphodiesterase, nucleoside 3′,5′-cyclic ... Kroll S, Phillips WJ, Cerione RA (March 1989). "The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the ...
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. cAMP is a second messenger, used for intracellular ... such as cyclic adenosine monophosphate, cyclic AMP). Cyclic AMP is synthesized from ATP by adenylate cyclase located on the ... Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in ... Since cyclic AMP is a second messenger and plays vital role in cell signalling, it has been implicated in various disorders but ...
Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current ... Némoz G, Zhang R, Sette C, Conti M (Apr 1996). "Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene ... "Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification ... "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene. 138 (1-2): 253-6. doi: ...
... for instance a bond in a molecule of cyclic AMP or cyclic GMP. An enzyme that plays an important role in the repair of ... Phosphodiesterase Phosphodiesterase inhibitor DNA replication, DNA, ATP Teichoic acid, DNase I PDE5 Nick (DNA) "Phosphodiester ... A phosphodiesterase is an enzyme that catalyzes the hydrolysis of phosphodiester bonds, ... Hydrolysis of phosphodiester bonds is catalyzed by phosphodiesterases, which are involved in repairing DNA sequences. The ...
"Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". The ... Nov 2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase ... "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides". The ... selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium". ...
Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific ... into AMP and GMP. These second messengers control many physiological processes. The cAMP is formed from ATP by the enzyme ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... Phosphodiesterase 5 (PDE5) is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder ...
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... An example is adenylate cyclase, which produces the second messenger cyclic AMP.[9] For this discovery, they won the 1994 Nobel ... which produces the second messenger cyclic AMP.[9]. *The 1988 Nobel Prize in Physiology or Medicine to George H. Hitchings, Sir ... cyclic-GMP phosphodiesterase. *Protein kinase G. *G alpha subunit Gα *GNAO1 ...
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic ... The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a ... "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family". Gene. 129 (2): 239-47. doi: ... "Entrez Gene: PDE4B phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)". Swerdlow, Neal R. ( ...
The activated OR in turn activates the intracellular G-protein, GOLF (GNAL), adenylate cyclase and production of cyclic AMP ( ... CaMKII will also activate phosphodiesterase, which will then hydrolyze cAMP. The effect of this negative feedback response ... "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons". Proc ... 21 (3): 495-504. doi:10.1016/s0896-6273(00)80561-9. PMID 9768837. S2CID 9860137. Yan, C; Zhao, AZ; Bentley, JK; Loughney, K; ...
... phosphodiesterase * EC 3.1.4.59: cyclic-di-AMP phosphodiesterase * EC 3.1.4.60: pApA phosphodiesterase * EC 3.1.4.61: cyclic 2, ... cyclic-AMP phosphodiesterase EC 3.1.4.54: N-acetylphosphatidylethanolamine-hydrolysing phospholipase D EC 3.1.4.55: ... CMP-N-acylneuraminate phosphodiesterase EC 3.1.4.41: sphingomyelin phosphodiesterase D EC 3.1.4.42: glycerol-1,2-cyclic- ... cyclic phosphate phosphodiesterase EC 3.1.4.57: phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase * EC 3.1.4.58: RNA ...
Dransfield DT, Bradford AJ, Smith J, Martin M, Roy C, Mangeat PH, Goldenring JR (Jan 1997). "Ezrin is a cyclic AMP-dependent ... "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". The EMBO Journal. 20 (8): 1921-30. doi: ... Beebe SJ, Salomonsky P, Holroyd C, Becker D (Dec 1993). "Differential expression of cyclic AMP-dependent protein kinase ... "Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and ...
Holden CA, Chan SC, Norris S, Hanifin JM (Oct 1987). "Histamine induced elevation of cyclic AMP phosphodiesterase activity in ... affects intracellular messaging including downstream signaling accomplished through various intermediaries such as cyclic AMP, ... cyclic GMP, calcium, and nuclear factor kappa B (NF-κB), a ubiquitous transcription factor thought to play an important role in ... 109 (3): 524-31. doi:10.1067/mai.2002.121944. PMID 11898002. Idzko M, la Sala A, Ferrari D, Panther E, Herouy Y, Dichmann S, ...
Phosphodiesterase (PDE) enzymes degrade cyclic di-AMP to the linear molecule 5'-pApA (phosphadenylyl adenosine). 5'-pApA is ... Cyclic di-AMP (also called c-di-AMP and c-di-adenosine monophosphate) is a second messenger used in signal transduction in ... Cyclic di-AMP has also been linked to bacterial RNA synthesis inhibition. c-di-AMP stimulates the production of (p)ppGpp, an ... At high concentrations, cyclic di-AMP binds to receptor and target proteins to control specific pathways. Elevated c-di-AMP ...
Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A (February 1987). "Inhibitors of cyclic AMP phosphodiesterase. 1. ... The exact mechanism of action is unclear, although it is known to be a phosphodiesterase inhibitor. It is a potent (IC50 = 36nM ... Phosphodiesterase inhibitor with antiplatelet activity. Condensation of benzyl chloride 1 with ethyl ester of glycine gives ... inhibitor of phosphodiesterase-II.[citation needed] It inhibits PDE-3 and phospholipase A2. ...
... cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]" (PDF). ... "The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both ... rolipram-sensitive cyclic AMP phosphodiesterase". Molecular and Cellular Biology. 10 (6): 2678-86. doi:10.1128/MCB.10.6.2678. ... cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)". Cellular Signalling. 6 (7): 793-812. doi:10.1016/0898-6568(94)00039-5. ...
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... van Calker D, Müller M, Hamprecht B (1978). "Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells". Nature ... June 1997). "cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes ... Bender AT, Beavo JA (September 2006). "Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use". Pharmacol. ...
... but an inhibition of the enzyme phosphodiesterase causing elevation of cyclic AMP and cyclic GMP[clarification needed] levels ... Papaverine has also been demonstrated to be a selective phosphodiesterase inhibitor for the PDE10A subtype found mainly in the ... August 2006). "Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis". ... Hebb AL, Robertson HA, Denovan-Wright EM (May 2008). "Phosphodiesterase 10A inhibition is associated with locomotor and ...
Whole genome sequencing results revealed that when Cyclic-di-AMP phosphodiesterase (GdpP) was disrupted in this bacterium, it ... 3 (1): 11-21. doi:10.1038/nrg700. PMID 11823787. S2CID 8934412.. *^ a b c Sanjuán R, Moya A, Elena SF (June 2004). "The ... 978-1-316-09302-3. .. *^ Dover GA, Darwin C (2000). Dear Mr. Darwin: Letters on the Evolution of Life and Human Nature. ... 3: e02001. doi:10.7554/elife.02001. PMC 3999860. PMID 24843013.. *^ Rodgers K, McVey M (January 2016). "Error-Prone Repair of ...
AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes ... DNA Oligonucleotide Phosphodiesterase Glutamate flavoring Kikunae Ikeda Umami Ajinomoto Tien Chu Ve-Tsin Glutamic acid Disodium ... AMP Or AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP: ADP + H2O → AMP + Pi AMP can also be ... AMP is also a component in the synthesis of RNA. AMP is present in all known forms of life. AMP does not have the high energy ...
Yoshida, M., Inaba, K., Ishida, K. and Morisawa, M. (1994) Calcium and cyclic AMP mediate sperm activation, but Ca2+ alone ... The cGMP signal is terminated by the hydrolysis of cGMP through phosphodiesterase (PDE) activity and inactivation of GC. On ... Cyclic GMP possibly opens cyclic nucleotide-gated (CNG) K+-selective channels, thereby causing hyperpolarization of the ... The consequential hyperpolarization activates hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. The ...
... cAMP or cyclic AMP) is a second messenger that has been implicated in facilitating mushroom body calcium influx in Drosophila ... This spatial specificity is regulated by the dunce (dnc) PDE, a cAMP-specific phosphodiesterase. If the dunce gene is abolished ... Coincidence Detection by Rutabaga Adenylyl Cyclase and Spatial Regulation by Dunce Phosphodiesterase". Neuron. 65 (4): 516-529 ... 5 (1): 1-10. doi:10.1101/lm.5.1.1. PMC 311238. PMID 10454369. S.E. Fahrbach (2006). "Structure of the mushroom bodies of the ...
Caffeine also increases cyclic AMP levels through nonselective inhibition of phosphodiesterase. "Caffeine has a three- ... Its derivatives include the energy carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine ... Adenosine used as a second messenger can be the result of de novo purine biosynthesis via adenosine monophosphate (AMP), though ... 28 (5 Suppl 61): S21-S23. PMID 21044428. Solinas M, Ferré S, You ZB, Karcz-Kubicha M, Popoli P, Goldberg SR (August 2002). " ...
cAMP levels are regulated through the activity of phosphodiesterase isozymes/isoforms, which degrades it to 5′-AMP. The ... When the β2-agonist binds and activates the β2-adrenoreceptor intracellular signaling becomes largely affected through cyclic ... R5 or R3: Hydroxyl group placed on carbon number 5 or 3 (meta position) gives direct action to the β-adrenergic receptor. R4: ... Van der Waals forces between aromatic catechol ring and Phe-290 in helix 6 residue and Val-114 in helix 3 residue reinforce the ...
"Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte". Development. 136 (11): ... and are regulated by the phosphodiesterase (PDE). This pathway can be triggered via two mechanisms: physiological stimulus ( ... Then, it converts adenosine triphosphate into cyclic AMP, which activates Protein kinase A. PKA leads to protein tyrosine ... Vaccari, S; Weeks JL, 2nd (September 2009). Hsieh, M; Menniti, FS; Conti, M. "Cyclic GMP signaling is involved in the ...
January 2012). "Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein ... Zhang Z, Klyachko V, Jackson MB (October 2007). "Blockade of phosphodiesterase Type 5 enhances rat neurohypophysial ... non-cyclic) dithiol nonapeptide called oxytoceine. It has been theorized that oxytoceine may act as a free radical scavenger, ... Retrieved 5 March 2022. Lee AG, Cool DR, Grunwald WC, Neal DE, Buckmaster CL, Cheng MY, et al. (August 2011). "A novel form of ...
α2 receptors also cause decreased intracellular cyclic AMP expression which results in smooth muscle relaxation or decreased ... "Inhibition of serotonin and noradrenaline reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential ... an effect mediated by decreased cyclic AMP-mediated phosphorylation-activation of the enzyme. ... 15 (3): 699-703. doi:10.1016/j.bmcl.2004.11.025. PMID 15664840. Mahaney PE, Vu AT, McComas CC, Zhang P, Nogle LM, Watts WL, et ...
... also increases cyclic AMP levels through nonselective inhibition of phosphodiesterase. Caffeine is a bitter, white ... The ICD-11 includes caffeine dependence as a distinct diagnostic category, which closely mirrors the DSM-5's proposed set of ... As a competitive nonselective phosphodiesterase inhibitor, caffeine raises intracellular cyclic AMP, activates protein kinase A ... Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases" (PDF). The Journal of Allergy and Clinical Immunology. 108 ( ...
Phosphodiesterase quickly converts cAMP to AMP, thus reducing the amount of cAMP that can activate protein kinase A. PKA is ... Cyclic+AMP-Dependent+Protein+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila cAMP- ... In cell biology, protein kinase A (PKA) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP ( ... The regulatory subunit has domains to bind to cyclic AMP, a domain that interacts with catalytic subunit, and an auto ...
Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K, Seino Y (Jul 1999). "The cyclic AMP response ... Yan C, Miller CL, Abe J (Mar 2007). "Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart". ... Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of ... Pati D, Meistrich ML, Plon SE (Jul 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP- ...
Whole genome sequencing results revealed that when Cyclic-di-AMP phosphodiesterase (GdpP) was disrupted in this bacterium, it ... Corrigan, Rebecca M.; Abbott, James C.; Burhenne, Heike; Kaever, Volkhard; Gründling, Angelika (1 September 2011). "c-di-AMP Is ... 3: e02001. doi:10.7554/elife.02001. PMC 3999860. PMID 24843013. Rodgers K, McVey M (January 2016). "Error-Prone Repair of DNA ... 155 (5): 376-86. doi:10.1016/j.resmic.2004.01.012. PMID 15207870. Sawyer SA, Parsch J, Zhang Z, Hartl DL (April 2007). " ...
September 2003). "Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system ... Erhardt PW, Chou YL (1991). "A topographical model for the c-AMP phosphodiesterase III active site". Life Sciences. 49 (8): 553 ... Lugnier C (March 2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific ... WO 03012030, Movsesian M, "Isoform-Selective Inhibitors and Activators of PDE3 Cyclic Nucleotide Phosphodiesterases", published ...
"Differential regulation of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozyme by cyclic AMP- ... Sharma, RK; Wirch, E; Wang, JH (May 25, 1978). "Inhibition of Ca2+-activated cyclic nucleotide phosphodiesterase reaction by a ... "Mechanism of activation of cyclic nucleotide phosphodiesterase: requirement of the binding of four Ca2+ to calmodulin for ... "Demonstration of bovine brain calmodulin dependent cyclic nucleotide phosphodiesterase isozymes by monoclonal antibodies". J ...
Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP ... The cAMP formed is degraded by phosphodiesterase 4 (PDE4) activated by an AKAP-anchored protein kinase A. Polymorphisms of the ... Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in ... which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate ( ...
Methylxanthines such as caffeine inhibit the action of cyclic nucleotide phosphodiesterase, which normally acts to break down ... AMP) and signal transduction in the form of cyclic adenosine monophosphate (cAMP). A2B and A3 receptors require concentrations ... Cyclic adenosine monophosphate, or cAMP, is a second messenger important in many cellular processes and is a critical factor in ... The inhibition of the phosphodiesterase would lead to a buildup of cAMP, increasing the activity of the second messenger ...
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP+phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.1.4) ... Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso GD, ...
Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]. *Cyclic Nucleotide Phosphodiesterases, Type 7 [D08.811.277.352.640.150 ... A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type ... "Cyclic Nucleotide Phosphodiesterases, Type 7" by people in this website by year, and whether "Cyclic Nucleotide ... "Cyclic Nucleotide Phosphodiesterases, Type 7" is a descriptor in the National Library of Medicines controlled vocabulary ...
In addition, may inhibit phosphodiesterase activity, leading to increased cyclic-3, 5-AMP within platelets and formation of ...
phosphodiesterase 3A - Phosphodiesterases, 3,5-cyclic nucleotide (PDEs). Detailed annotation on the structure, function, ... 1987) Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2- ... 4. Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A. (1987) Inhibitors of cyclic AMP phosphodiesterase. 1. ... CGI-PDE A , phosphodiesterase 3A cGMP inhibited , phosphodiesterase 3A, cGMP-inhibited , phosphodiesterase 3A, cGMP inhibited ...
... cyclic-AMP phosphodiesterase. 421692 (PDE7B). BRITE hierarchy. SSDB. Ortholog. Paralog. Gene cluster. GFIT. ... Ontology (2) KEGG BRITE (2) Pathway (2) KEGG PATHWAY (2) Chemical substance (3) KEGG COMPOUND (3) Chemical reaction (2) KEGG ... 3. Hydrolases. 3.1 Acting on ester bonds. 3.1.4 Phosphoric-diester hydrolases. 3.1.4.53 3,5- ... high affinity cAMP-specific 3,5-cyclic phosphodiesterase 7 [EC:3.1.4.53]. ...
... cyclic-AMP phosphodiesterase activity]. GO:0005829 [cytosol]. GO:0006198 [cAMP catabolic process]. GO:0007165 [signal ... This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by ... cyclic-AMP phosphodiesterase activity]. GO:0007165 [signal transduction]. GO:0008081 [phosphoric diester hydrolase activity]. ... cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5-monophosphates and ...
... cyclic AMP) metabolizing enzyme) activity leads to accumulation of intracellular cyclic AMP ... Roflumilast and its active metabolite (roflumilast N-oxide) are inhibitors of phosphodiesterase (PDE)-4 ... Inhibition of PDE4 (a major cyclic 3′,5′-adenosine monophosphate ( ... 5. This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty ...
... cyclic-AMP phosphodiesterase. Reaction:. adenosine 3′,5′-cyclic phosphate + H2O = AMP. ... Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. Cyclic nucleotide specific phosphodiesterases of Leishmania major ... cyclic-AMP 5′-nucleotidohydrolase. Comments:. Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3′,5′-cAMP ... Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei. Biochim. Biophys. Acta ...
Background: KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE) 3,4 and 5 isoenzymes to ... suppress the degradation of cyclic AMP and cyclic GMP. However, whether KMUP-1 has any effect on osteoblast differentiation is ... Andries Bickerweg 5. 2517 JP The Hague. Netherlands. +31 (0) 70 30 21 970. [email protected] ...
Cyclic-AMP Phosphodiesterases, Actins, Animals, Cell Adhesion, Cell Line, Cell Movement, Colforsin, Cyclic AMP, Cyclic AMP- ... Dependent Protein Kinases, Cyclic Nucleotide Phosphodiesterases, Type 4, Embryo, Mammalian, Enzyme Activation, Fibroblasts, ... In particular, by using the specific inhibitor rolipram, we identify the PDE4 family of cAMP-specific phosphodiesterases as ... In particular, by using the specific inhibitor rolipram, we identify the PDE4 family of cAMP-specific phosphodiesterases as ...
Neither the effects of relaxin nor the inhibition of relaxin by LY294002 was mediated by the activity of phosphodiesterases. ... Cyclic AMP * Phosphatidylinositol 3-Kinases Grant support * R01 GM060419/GM/NIGMS NIH HHS/United States ... Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3,5-monophosphate by relaxin Mol ... Selective inhibitors for phosphoinositide 3-kinase (PI3K), such as wortmannin and LY294002, showed a dose-dependent inhibition ...
... cyclic-AMP phosphodiesterases, analysis of variance, cyclic amp, dose-response relationship, Drug, drug interactions, Forskolin ... Islet cyclic AMP levels, which were not modified by forskolin (10-6 M), SK&F 94836 (10-4 M) or Org 9935 (10-5 M) were ... Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase ... cyclic AMP PDE activity.7. The PDE activity of both supernatant and pellet fractions were consistently inhibited by SK&F94836 ...
... cyclic-AMP phosphodiesterase activity GO:0004115 * phosphatidylinositol-mediated signaling GO:0048015 ...
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... An example is adenylate cyclase, which produces the second messenger cyclic AMP.[9] For this discovery, they won the 1994 Nobel ... which produces the second messenger cyclic AMP.[9]. *The 1988 Nobel Prize in Physiology or Medicine to George H. Hitchings, Sir ... cyclic-GMP phosphodiesterase. *Protein kinase G. *G alpha subunit Gα *GNAO1 ...
Rank order of affinity at phosphodiesterase 1A cyclic GMP > cyclic AMP Rank order of affinity at phosphodiesterase 1B cyclic ... Rank order of affinity at phosphodiesterase 1C cyclic GMP = cyclic AMP Rank order of affinity at phosphodiesterase 2A cyclic ... Rank order of affinity at phosphodiesterase 4A cyclic AMP >> cyclic GMP Rank order of affinity at phosphodiesterase 4B cyclic ... Rank order of affinity at phosphodiesterase 4C cyclic AMP >> cyclic GMP Rank order of affinity at phosphodiesterase 4D cyclic ...
... cyclic-AMP phosphodiesterase activity(GO:0004115). 0.1. 1.4. GO:0042975. peroxisome proliferator activated receptor binding(GO: ... l(3)mbt-like 3 (Drosophila). chr12_+_59989918. 1.19. ENST00000547379.1. ENST00000549465.1. SLC16A7. solute carrier family 16 ( ... TAO kinase 3. chr10_+_104263743. 1.08. ENST00000369902.3. ENST00000369899.2. ENST00000423559.2. SUFU. suppressor of fused ... immunoglobulin heavy variable 3/OR15-7 (pseudogene). chr15_-_75748115. 0.29. ENST00000360439.4. SIN3A. SIN3 transcription ...
Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain studies on cyclic 3,5-nucleotide ... Release of the phophodiesterase activator by cyclic AMP-dependent ATP:protein phosphotransferase from subcellular fractions of ... Modulation of striatal cyclic nucleotide phosphodiesterase by calmodulin: Regulation by opiate and dopamine receptor activation ... Cyclic nucleotide phosphodiesterase activity in 10-nm filaments and microtubule preparations from bovine brain ...
Heme-regulated cyclic AMP phosphodiesterase; formerly hypothetical protein YddU. *. Species Escherichia coli [TaxId:562] [ ... core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha. ... Family d.110.3.2: Heme-binding PAS domain [55789] (3 proteins). *. Protein Direct oxygen sensor protein, DOS [111118] (1 ...
In addition, may inhibit phosphodiesterase activity, leading to increased cyclic-3, 5-AMP within platelets and formation of ...
Cyclic nucleotide turnover/signalling in the IUPHAR/BPS Guide to PHARMACOLOGY. ... Exchange protein activated by cyclic AMP (EPACs) C. *Phosphodiesterases, 3,5-cyclic nucleotide (PDEs) C ... 2013) Phosphodiesterases: Regulators of cyclic nucleotide signals and novel molecular target for movement disorders. Eur J ... 2011) Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions. Physiol Rev, 91 (2): ...
CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL ... Effects of cyclic adenosine and cyclic guanosine nucleotides and theophylline on gastrin synthesis and secretion in rat antral ...
... cyclic AMP) metabolizing enzyme) activity leads to accumulation of intracellular cyclic AMP. Specific mechanism(s) by which ... Apremilast is a phosphodiesterase-4 inhibitor specific for cAMP, resulting in increased intracellular cAMP levels. It may ... The mechanisms by which phosphodiesterase-4 (PED4) inhibitors elicit anti-inflammatory effects are not completely understood. ... Inhibition of PDE4 (a major cyclic 3′,5′-adenosine monophosphate ( ...
Activator of cGMP-dependent protein kinases I α, I β & type II and cGMP-gated ion channels (cyclic GMP agonist). Increased ... Chem., 274, 8391 - 8404 (1999), "Cyclic AMP- and Cyclic GMP-Dependent Protein Kinases Differ in Their Regulation of Cyclic AMP ... "The Binding of Cyclic Nucleotide Analogs to a Purified Cyclic GMP- Stimulated Phosphodiesterase from Bovine Adrenal Tissue" ... Clair T., Ally S., Tagliaferri P., Robins R. K.Cho-Chung Y. S., FEBS Lett., 224, 377 - 384 (1987), "Site-selective Cyclic AMP ...
CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL ... cyclic phosphodiesterase 4B. Adenosine receptor A2a. cAMP-specific 3,5-cyclic phosphodiesterase 4A. cGMP-specific 3,5- ... cyclic phosphodiesterase. Histone deacetylase 2. Adenosine receptor A2b. cGMP-inhibited 3,5-cyclic phosphodiesterase A. ... the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline ...
Cyclic-AMP Phosphodiesterases [D12.776.476.008] * 3,5-Cyclic-GMP Phosphodiesterases [D12.776.476.009] ... Tumor Necrosis Factor alpha-Induced Protein 3 [D12.644.360.950] * Tumor Protein, Translationally-Controlled 1 [D12.644.360.963] ... Tumor Necrosis Factor alpha-Induced Protein 3 [D12.776.476.938] * Tumor Protein, Translationally-Controlled 1 [D12.776.476.941] ...
Newer Developments in the Determination of Cyclic AMP and Other Cyclic Nucleotides, Adenylate Cyclase, and Phosphodiesterase, ... Analysis of Cyclic 3′,5′-Adenosine Monophosphate and Cyclic 3′,5′-Guanosine Monophosphate, ... This book, Methods of Soi/Analysis: Chemical Methods, is Part 3 of SSSA Book Series No. Biochemical analysis techniques ... Newer Developments in the Determination of Cyclic AMP and Other Cyclic Nucleotides, Adenylate Cyclase, and Phosphodiesterase, ...
cAMP-specific phosphodiesterase, putative 0.0058. 0.0155. 0.3921. Loa Loa (eye worm). cyclic AMP specific phosphodiesterase ... cyclic nucleotide phosphodiesterase, putative 0.0058. 0.0155. 1. Echinococcus granulosus. dual 35 cyclic AMP and GMP ... camp-specific 35-cyclic phosphodiesterase 0.0058. 0.0155. 0.0556. Toxoplasma gondii. 35-cyclic nucleotide phosphodiesterase ... cyclic phosphodiesterase R153.1, putative 0.0418. 0.2052. 1. Trichomonas vaginalis. cyclic nucleotide phosphodiesterase, ...
... noncholinergic stimulation by isozyme-selective phosphodiesterase inhibitors in guinea pig trachea. Download Prime PubMed App ... Cyclic-AMP PhosphodiesterasesAnimalsAtropineCyclic AMPCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide ... Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO/cyclic GMP pathway. ... Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside. ...
  • 1992) 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. (guidetopharmacology.org)
  • 1992) Inhibitors of blood platelet cAMP phosphodiesterase. (guidetopharmacology.org)
  • Selective inhibitors for phosphoinositide 3-kinase (PI3K), such as wortmannin and LY294002, showed a dose-dependent inhibition of relaxin-mediated increases in cAMP, specific for the second peak of the relaxin time course. (nih.gov)
  • 1. We examined various type-selective phosphodiesterase (PDE) inhibitors on glucose-induced insulin secretion from rat isolated islets, on islet PDE activity and on islet cyclic AMP accumulation in order to assess the relationship between type-selective PDE inhibition and modification of insulin release. (strath.ac.uk)
  • Keravis T, Lugnier C. (2012) Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. (guidetoimmunopharmacology.org)
  • The effect of the phosphodiesterase (PDE) isozyme selective inhibitors siguazodan (PDE III-selective), rolipram (PDE IV-selective), denbufylline (PDE IV-selective) and zaprinast (PDE V-selective) was examined on the relaxant responses to field stimulation and on relaxations elicited by the nitric oxide donor 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1). (unboundmedicine.com)
  • The response to field stimulation in the presence of alpha-chymotrypsin (the putative nitric oxide component), at all the frequencies tested, was potentiated significantly by the PDE IV inhibitors rolipram (1 and 10 microM) and denbufylline (3 and 10 microM) as were responses to SIN-1. (unboundmedicine.com)
  • Fredholm BB, Lindgren E: The effect of alkylxanthines and other phosphodiesterase inhibitors on adenosine-receptor mediated decrease in lipolysis and cyclic AMP accumulation in rat fat cells. (chinaplantextract.com)
  • This study aimed to assess the activity of two phosphodiesterase (PDE) inhibitors, namely GRMS-55 and racemic lisofylline ((±)-LSF)) in vitro and in animal models of immune-mediated disorders. (springer.com)
  • April 2012,some men puÃ2 occur in the third-fourth decade ofconstitute contraindications or 8 tablets 100 mg 200.800phosphodiesterase (PDE) inhibitors on human and rabbit. (bahamasuncensored.com)
  • In the presence of phosphodiesterase inhibitors (theophylline and 3-isobutyl-1-methylxanthine), the basal [3H]ACh output was increased. (aspetjournals.org)
  • There was a significantly greater stimulation when forskolin was used to incite endogenous cAMP synthesis and phosphodiesterase inhibitors were simultaneously applied to prevent cAMP breakdown. (aspetjournals.org)
  • From a naturopathic perspective psoriasis is caused a toxic allergen, protein maldigestion, increased intestinal permeability, bowel toxicity, excess inflammation, leading to excess polyamines in the gut causing an imbalance of cAMP : cGMP and excess phosphodiesterase inhibitors (the enzyme involved in breaking down cGMP). (carahealth.com)
  • Cilostazol and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively. (rpsi.ir)
  • Inhibitors of type IV phosphodiesterases reduce the toxicity of MPTP in substantia nigra neurons in vivo. (ox.ac.uk)
  • The interplay of signals arising in both follicle cells and oocytes themselves (1 2 4 6 7 regulates synthesis and degradation of oocyte cAMP via adenylyl cyclases and cyclic nucleotide phosphodiesterases (PDEs) respectively. (immune-source.com)
  • According to studies, cAMP signaling is impaired in depression by enzymes called phosphodiesterases (PDEs). (health.news)
  • Phosphodiesterases (PDEs) are enzymes that hydrolyze the second messengers - 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP). (springer.com)
  • Caffeine is a potent albeit nonselective inhibitor of phosphodiesterase (PDEs), but how the health-related effects of caffeine are linked to PDEs is unknown. (biorxiv.org)
  • Phosphodiesterases (PDEs) participate in cognition, motor functions, and behavior as well as also offers neuroprotection. (rjptonline.org)
  • Spread of cAMP and cGMP is further shaped by cyclic nucleotide phosphodiesterases (PDEs) for orchestration of intracellular microdomain signaling. (preprints.org)
  • Recently discovered rhodopsin phosphodiesterase gene from protists established new and direct biological connection between light and PDEs. (preprints.org)
  • It catalyses the following reaction adenosine 3′,5′-cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. (wikipedia.org)
  • This enzyme is specific for 3′,5′-cAMP and does not hydrolyse other nucleoside 3′,5′-cyclic phosphates such as cGMP ( cf . (enzyme-database.org)
  • Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. (selfdecode.com)
  • This is a membrane-bound enzyme that converts ATP to 3 I ,5 I -adenosine monophosphate (commonly called cyclic AMP, or cAMP). (pharmacy180.com)
  • This happens through an enzyme called phosphodiesterase ( shown at "5" below). (learn-biology.com)
  • The following ENZYME entries belong to class 3. (expasy.org)
  • Their main interest was to learn more about the effect of quercetin on the PDE enzyme, or phosphodiesterase. (ironmagazine.com)
  • GC41635 Phosphodiesterase 4 Inhibitor Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme. (glpbio.cn)
  • The in vivo mechanism of action is not entirely clear, but an inhibition of the enzyme phosphodiesterase causing elevation of cyclic AMP and cyclic GMP [ clarification needed ] levels is significant. (cloudfront.net)
  • Central to the protective actions of cyclic AMP is an enzyme, EPAC1, which suppresses multiple inflammatory signalling pathways in VECs, through selective changes in gene activity. (hw.ac.uk)
  • 2016) Ser/Thr phosphorylation regulates the Fatty Acyl-AMP Ligase activity of FadD32, an essential enzyme in mycolic acid biosynthesis. (ipbs.fr)
  • For the science geeks, caffeine belongs to the larger class of compounds known as methylxanthines and blocks phosphodiesterase, the enzyme responsible for the breakdown of cyclic-AMP. (robertclaremd.com)
  • Receptors for cyclic-AMP reside throughout the body and blocking this key enzyme is the primary way caffeine exerts its physiologic effects. (robertclaremd.com)
  • Although treatment with recombinant uricase can be an appealing choice, the enzyme provides features that make it an inadequate pharmaceutical for persistent make use of, including poor solubility at physiologic pH, speedy clearance, and immunogenicity [2,3]. (rectalcancersite.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Phosphodiesterase 10A (PDE10A) in Tissue homogenates and other biological fluids. (lotusbiotechnologies.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adenylate Kinase 3 (AK3) in serum, plasma, cerebrospinal fluid and other biological fluids. (allelisakits.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Adenylate Kinase 3 (AK3) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (allelisakits.com)
  • Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP. (ouhsc.edu)
  • Formation of the cyclic pyrimidine nucleotide cyclic cytidine 3',5'-monophosphate (cCMP) by cytidylyl cyclases is debated. (biomedcentral.com)
  • Modulation of cAMP concentration can take place at the level of adenylyl cyclases or cAMP phosphodiesterases. (archives-ouvertes.fr)
  • Guanosine 3',5'-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. (glpbio.cn)
  • Ca2+ and cAMP play a critical role for cardiac excitation-contraction-coupling and are known to interact with each other, for example via Ca2+-dependent modulation of PDE1 and adenylyl cyclases 5 and 6 activities. (uni-goettingen.de)
  • Effects of cyclic adenosine and cyclic guanosine nucleotides and theophylline on gastrin synthesis and secretion in rat antral organ culture. (ouhsc.edu)
  • AbstractEvidence is presented here confirming the identification of guanosine 3′: 5′-monophosphate (c GMP) in the tissue of higher plants. (copernicus.ltd)
  • Heterotrimeric G protein complexes are composed of 3 subunits, including an α-subunit which acts as the main signal mediator and whose active state is regulated via GTP (guanosine-5′-triphosphate) recruitment and hydrolysis. (cisbio.eu)
  • Guanosine 5′- (trihydrogen - diphosphate), or GTPγS, is a stable analog (hydrolyzable or non-hydrolyzable) of GTP and benefits from various physiological actions, such as the stimulation of guanine nucleotide-binding proteins. (cisbio.eu)
  • Second messengers, cyclic adenosine 3'-5'-monophosphate (cAMP) and cyclic guanosine 3'-5'-monophosphate (cGMP) are playing important roles in many animal cells by regulating intracellular signaling pathways and modulating cell physiology. (preprints.org)
  • Rapid microassay of adenosine 3',5'-monophosphate phosphodiesterase activity. (wikidata.org)
  • Oocytes find the capability to continue meiosis during this time period and depend on 3'5′-cyclic adenosine monophosphate (cAMP) to avoid premature resumption. (conferencedequebec.org)
  • Ervens J, Seifert R: Differential modulation by N4, 2'-O-dibutyryl cytidine 3':5'-cyclic monophosphate of neutrophil activation. (biomedcentral.com)
  • COCs expanded in vitro with FSH or EGF underwent the same changes, whereas those expanded with 8-bromo-adenosine-3',5'-cyclic monophosphate (8-Br-cAMP) maintained integrity for a longer time. (torvergata.it)
  • The "AMP" part of cyclic AMP stands for adenosine monophosphate . (learn-biology.com)
  • The cyclic adenosine 3',5'-monophosphate signalling pathway is now recognised to transduce signals in a compartmentalised manner such that individual stimuli only engage a subset of the pathway components that are physically constrained within defined subcellular locales, thus resulting in a precise functional outcome. (ox.ac.uk)
  • cAMP (cyclic adenosine monophosphate) is a second messenger used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. (glpbio.cn)
  • Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes. (cdc.gov)
  • Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases. (ox.ac.uk)
  • 3',5'-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that regulates multiple physiological functions by acting in distinct subcellular microdomains. (uni-goettingen.de)
  • PDE enzymes would in any other case break down one thing known as cyclic adenosine monophosphate (cAMP). (drhealth.biz)
  • Ligand binding to MC4R activates adenylyl cyclase, resulting in increased levels of intracellular cyclic adenosine monophosphate (cAMP), a secondary messenger that regulates several cellular processes. (bvsalud.org)
  • Cyclic adenosine monophosphate responsive element-binding protein-1-regulated transcription coactivator-1 (CRTC1) is a cytoplasmic coactivator that translocates to the nucleus in response to cAMP and is reportedly involved in obesity. (bvsalud.org)
  • Cyclic AMP (cyclic adenosine 3',5'-monophosphate, or simply cAMP) is one of the most important GPCR intracellular mediators. (cisbio.eu)
  • Neither the effects of relaxin nor the inhibition of relaxin by LY294002 was mediated by the activity of phosphodiesterases. (nih.gov)
  • PDE3 inhibition no more managed meiotic arrest if suffered beyond 17.65 hours of IVM, 3 hours ahead of resumption of meiosis. (conferencedequebec.org)
  • Nevertheless, PDE3 inhibition in COC treated with OA for 3 hours considerably delayed meiosis in the intermediate stage. (conferencedequebec.org)
  • Stimulation of endogenous adenylate cyclase with forskolin or inhibition of phosphodiesterase with rolipram produced similar effects. (torvergata.it)
  • These results suggest that the flavonoids act synergistically with epinephrine on beta-adrenergic receptor and not through phosphodiesterase inhibition to stimulate adipocyte lipolysis. (ironmagazine.com)
  • Dr. Kozio-White showed that phosphoinositide 3-kinase delta inhibition abrogated and/or prevented agonist-induced bronchoconstriction. (rutgers.edu)
  • Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways. (ox.ac.uk)
  • Alternatively, PKG activation and phosphodiesterase (PDE5/6) inhibition significantly reduce the time to the onset of anoxic coma. (biologists.com)
  • Cyclic nucleotides are second messengers generated by cyclase enzymes from precursor triphosphates and hydrolysed by phosphodiesterases. (guidetoimmunopharmacology.org)
  • The cellular actions of these cyclic nucleotides are mediated through activation of protein kinases ( cAMP - and cGMP -dependent protein kinases), ion channels ( cyclic nucleotide-gated, CNG , and hyperpolarization and cyclic nucleotide-gated, HCN ) and guanine nucleotide exchange factors (GEFs, Epac ). (guidetoimmunopharmacology.org)
  • These purine cyclic nucleotides activate PKA and PKG, respectively. (biomedcentral.com)
  • So far, there was no evidence of further cyclic nucleotides acting as second messengers. (biomedcentral.com)
  • Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. (nih.gov)
  • Gq-coupled GPCRs stimulate PLC-β, which catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to IP3 and diacylglycerol (DAG). (cisbio.eu)
  • The single phosphate group in cyclic AMP is connected to the ribose sugar in the molecule with two covalent bonds). (learn-biology.com)
  • Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. (nih.gov)
  • PMID: 10639539] 192 A. Then if we choose the same standard state for both liquid phases, who described a procedure forex trading simple moving average involved splenectomy, resection of the pancreatic tail, and then creation of an end-to-end anastomosis between the transected end of the pancreas and a Roux-en-Y limb of jejunum. (qrforex.com)
  • Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. (selfdecode.com)
  • Caffeine and 3-methylxanthine are the only theophylline metabolites with pharmacologic activity. (selfdecode.com)
  • 3-Isobutyl-1-methylxanthine, an analog of theophylline that inhibits phosphodiesterase, potentiated the effect of isoproterenol in suppressing collagen production. (jci.org)
  • The enhancement of forskolin-stimulated release by theophylline or 3-isobutyl-1-methylxanthine strongly implicates a synergistic interaction between the two. (aspetjournals.org)
  • In the presence of 1 mM theophylline, glucagon-stimulated cyclic AMP levels reached a maximum by 2 min at 30 C. The level attained was higher and more sustained in fed obese than in fed lean rats. (kipdf.com)
  • Apart from obesity, the nutritional state seems to affect the early steps of glucagon action in isolated rat liver cells: both glucagon binding to receptor sites and glucagon-stimulated cyclic AMP levels in the presence of theophylline were found to be higher in cells of fed than in those of fasted rats (13). (kipdf.com)
  • These data indicate that, in addition to the obese or non-obese state of the animal, dietary conditions may affect both the binding capacity of hormone receptors and glucagon-stimulated cyclic AMP production. (kipdf.com)
  • Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. (dbcls.jp)
  • Virus nucleic acids are predominantly recognized by Toll-like receptors (TLR3 for double-stranded RNA [dsRNA], TLR7 for single-stranded RNA [ssRNA], and TLR9 for CpG DNA) in the endosome and by retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated gene 50 (MDA5), cyclic GMP-AMP synthase DNA (cGAS), and other receptors in the cytosol (1, 2). (icce2013bali.org)
  • These receptors trigger several cascades of signal transduction pathways, ultimately activating the critical transcription factors nuclear factor B (NF-B) and interferon regulatory factor 3 (IRF3), inducing the robust expression of type I interferons (IFNs), other cytokines, and chemokines (3). (icce2013bali.org)
  • Cyclic AMP may enter oocytes from adjacent cumulus cells via gap junctions (2 6 Recent studies in rodents however demonstrated that PF-04979064 active oocyte adenylyl cyclase contributes to meiotic blockade (8) which can be released by microinjection of oocytes with antibodies that inactivate Gs the heterotrimeric GTP-binding protein that activates adenylyl cyclase (9). (immune-source.com)
  • Imagine a more complicated diagram in which adenylyl cyclase ("5") is going to catalyze the production of many cAMPs ("7"), each of which will in turn activate many proteins ("8") so that at the end of the process, millions of enzymes will have been activated. (learn-biology.com)
  • 2" is adenylyl cyclase, which converts ATP to cyclic AMP. (learn-biology.com)
  • In particular, by using the specific inhibitor rolipram, we identify the PDE4 family of cAMP-specific phosphodiesterases as critical regulators of this process. (ed.ac.uk)
  • Phosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in various cell types involved in allergic airway inflammation. (jci.org)
  • A combination of pharmacological and genetic approaches was used to determine the role of type 4 cAMP-specific cyclic nucleotide phosphodiesterase 4 (PDE4) in reversing α 2 -adrenoceptor-mediated anesthesia, a behavioral correlate of emesis in non-vomiting species. (jci.org)
  • Pharmacology Biochemistry and Behavior (1986) 24 (5): 1281. (biologists.com)
  • Comparative Biochemistry and Physiology Part C: Comparative Pharmacology (1983) 75 (1): 5. (biologists.com)
  • General Pharmacology: The Vascular System (1981) 12 (3): 161. (biologists.com)
  • He is a member of a number of scientific and professional societies, including the American Society for Pharmacology and Experimental Therapeutics and the Society for Neuroscience, is a Fellow of the American College of Neuropsychopharmacology, and chaired the Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases. (buffalo.edu)
  • [3] Signaling molecules bind to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn activates a particular G protein. (wikipedia.org)
  • Cyclic AMP activates the cAMP-dependent proteins kinase (PKA) by binding to both regulatory subunits, liberating both energetic catalytic subunits. (conferencedequebec.org)
  • We confirmed that cCMP activates the purified cyclic nucleotide-dependent protein kinases cAK and cGK. (biomedcentral.com)
  • relaxin-3 binds to and activates RXFP1, RXFP3 and RXFP4. (guidetopharmacology.org)
  • Human relaxin-3 activates RXFP1 but not RXFP2, is the cognate ligand for RXFP3 and also activates RXFP4. (guidetopharmacology.org)
  • The second messenger, cAMP, is subsequently degraded to AMP, and the increase in the intracellular AMP levels activates AMP-dependent protein kinase (AMPK). (bvsalud.org)
  • Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans. (rhea-db.org)
  • Through protein kinase A-catalyzed (PKA-catalyzed) phosphorylation of unidentified proteins cAMP prevents activation of maturation-promoting factor (MPF) and MAPK signaling in Cdc42 oocytes and inhibits the spontaneous maturation that occurs in vitro thus maintaining meiotic arrest (1-5). (immune-source.com)
  • GC18751 Reticulol Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 uM). (glpbio.cn)
  • Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. (ncats.io)
  • Since cAMP blocks meiotic maturation of mammalian and amphibian oocytes in vitro and cyclic nucleotide phosphodiesterase 3A (PDE3A) is primarily responsible for oocyte cAMP hydrolysis we generated PDE3A-deficient mice by homologous recombination. (immune-source.com)
  • Data represent 2 separate experiments ( n = 3 for all PBS groups, n = 7 for WT HDM, n = 5 for both PDE3A -/- and PDE3B -/- HDM groups) and are shown as the mean ± SEM. (jci.org)
  • Armani A, Marzolla V, Rosano GM, Fabbri A, Caprio M. (2011) Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism? (guidetoimmunopharmacology.org)
  • 5 PGI 2 synthase expression has been reported to be decreased in lung tissues from patients with severe PH. (dovepress.com)
  • maturation in oocytes was restored by inhibiting protein kinase A (PKA) with adenosine-3? (immune-source.com)
  • 5 monophosphorothioate Rp-isomer (Rp-cAMPS) or by injection of protein kinase inhibitor peptide (PKI) or mRNA coding for phosphatase CDC25 which confirms that increased cAMP-PKA signaling is responsible for the meiotic blockade. (immune-source.com)
  • Evidence is provided to support the possible involvement of extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol-3 kinase/ protein kinase B (PI3K/AKT) pathways in EGCG-mediated protection against corticosterone-induced neuron injuries. (semanticscholar.org)
  • AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. (cusabio.com)
  • The 3′,5′-cyclic AMP (cAMP)/protein kinase A (PKA) signaling pathway is an important signal transduction pathway. (health.news)
  • This signaling pathway is independent of increases in cyclic AMP and protein kinase A activation. (rutgers.edu)
  • Desensitization of TLRs (ergo tolerance) occurs either through decreased receptor expression or increased inhibitory regulators [such as IL-1-receptor-associated kinase 3 (IRAK3/IRAK-M) or Suppressor of Cytokine Signaling 1 (SOCS1)] in response to prolonged exposure to commensal microorganisms. (scholars.direct)
  • Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. (uni-freiburg.de)
  • indicates that the protein contains two domains (at least), one of which performs the role Glutamate 5-kinase and the other which performs the role RNA-binding C-terminal domain PUA . (bv-brc.org)
  • PDF] Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice. (semanticscholar.org)
  • Next generation sequencing applied to tissue transcriptomes (RNA-Seq) is an approach for screening the expression of functional candidate genes and consequently is possible identify important molecular mechanisms that generate variation in pathways resulting in different tissue phenotypes [ 5 , 6 ]. (biomedcentral.com)
  • 10] Z. Zidek: "Adenosine-cyclic AMP pathways and cytokine expression", Eur. (edu.pl)
  • For instance, S. epidermidis secretes modulins that inhibit pathogenic strains of bacteria including S. aureus and group A Streptococcus , lipoteichoic acid to inhibit skin inflammation through TLR-2/-3-mediated pathways, and increases keratinocyte expression of AMPs through a TLR2 dependent mechanism to enhance pathogenic microorganism destruction [ 8 ]. (scholars.direct)
  • 3 Drugs targeting the three pathways are currently available, and have been shown to be useful. (dovepress.com)
  • The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. (rhea-db.org)
  • AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). (cusabio.com)
  • Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. (cdc.gov)
  • In addition, 16S rDNA gene sequencing analysis showed that AMP treatment helped restore the imbalanced ecosystem of gut microbes, increased the proportion of Bacteroidetes and Proteobacteria, and increased species richness. (bvsalud.org)
  • J Immunol (1999) 162 (3): 1707-1716. (aai.org)
  • The family of second messengers now includes c-di-AMP and distinct versions of mixed cyclic GMP-AMP (cGAMP) compounds. (nature.com)
  • Background: KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE) 3,4 and 5 isoenzymes to suppress the degradation of cyclic AMP and cyclic GMP. (fip.org)
  • Purification of cyclic 3',5'-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to Sepharose. (wikidata.org)
  • Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. (cusabio.com)
  • Nevertheless, prostaglandin E2 (PGE2), a ubiquitous inflammatory mediator, is able to override IL-5-induced survival signals [ 4 , 5 ], ultimately inducing apoptosis in developing eosinophils. (hindawi.com)
  • Furthermore, AMP treatment enhanced the phosphorylation of PI3K/AKT and decreased the expression of its downstream apoptosis-related proteins in liver, thus effectively alleviating TAA-induced liver fibrosis. (bvsalud.org)
  • Apoptosis is essential for tissue homeostasis, for instance, in the development of and the negative/positive selection of T lymphocytes, whereas abnormalities in apoptosis are responsible for pathological diseases, such as cancer, autoimmune syndromes, and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, and Huntington's disease) (5,C8). (icce2013bali.org)
  • MATERIALS AND METHODS: The human microvascular endothelial tissues microarray datasets (GSE11341) of lung and cardiac expose to hypoxia (1% O2) for 3, 24 and 48 h were retrieved from the public repository. (bvsalud.org)
  • Impaired phosphodiesterase (PDE) function and mitochondrial Ca 2+ - [Ca 2+ ]m signaling leads to cardiac failure, ischemic damage and dysfunctional learning and memory. (biorxiv.org)
  • cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology. (ox.ac.uk)
  • Project End inflammatory border:( secured by prolongation): The Update of cardiac resource sensation in the United States is hereby 5 million functions, with more than 500,000 thoracic churches calculated per polypeptide. (augenta.net)
  • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3]. (enzyme-database.org)
  • Hickman, J.W., Tifrea, D.F. & Harwood, C.S. A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels. (nature.com)
  • Isoprenaline (5 nM and 10 μM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO) [3] . (medchemexpress.com)
  • Cilostazol, a phosphodiesterase-3 inhibitor indicated for treating intermittent claudication, has been shown to induce migraine-like attacks in healthy volunteers and patients with migraine without aura. (clinicalpainadvisor.com)
  • Neuroprotective potential of Cilostazol in 3-NP provoked Huntington's disease-associated symptoms. (rjptonline.org)
  • The present investigation was framed to analyze the neuro-defensive characteristics of cilostazol PDE3 inhibitor over the 3-NP induced behavioral, striatal and mitochondrial deficits. (rjptonline.org)
  • In this investigation, cilostazol offered neurodefensive effects which were established by behavioral and biochemical paradigms, which confirmed the potent neurodefensive aspect of cilostazol in 3-NP provoked behavioral and biochemical abnormalities. (rjptonline.org)
  • Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke. (rjptonline.org)
  • Evaluation of antidepressant and anxiolytic activity of phosphodiesterase 3 inhibitor - cilostazol. (rjptonline.org)
  • 7. Kumar A, Kumar A, Jaggi AS, Singh N. Efficacy of Cilostazol a selective phosphodiesterase-3 inhibitor in rat model of Streptozotocin diabetes induced vascular dementia. (rjptonline.org)
  • 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. (guidetopharmacology.org)
  • 8. Sudo T, Tachibana K, Toga K, Tochizawa S, Inoue Y, Kimura Y, Hidaka H. (2000) Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. (guidetopharmacology.org)
  • In addition, may inhibit phosphodiesterase activity, leading to increased cyclic-3', 5'-AMP within platelets and formation of potent platelet activator thromboxane A2. (medscape.com)
  • Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-K m cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells [1] . (medchemexpress.com)
  • Of major interest is the fact that the activity of two different forms of phosphodiesterases is controlled by the level of intracellular cGMP. (archives-ouvertes.fr)
  • Dose-(0-250 microM) and time-(0-2 hr) course studies, showed that they stimulated phosphodiesterase (PDE) activity and simultaneously exert cyclic AMP accumulation. (ironmagazine.com)
  • The c GMP activity detected in fruits of Zizyphus jujuba was separated from the c AMP activity also present. (copernicus.ltd)
  • In some medical images, Chan SC, Stevens S, Hanifin JM (1983) Increased leukocyte histamine release with elevated cyclic AMP-phosphodiesterase activity in atopic dermatitis. (goforexyourself.com)
  • In parallel to, 3-NP treated rats exhibit biochemical changes such as increased oxidative stress (enhanced lipid peroxides, reduced glutathione, catalase, and superoxide dismutase), disturbed cholinergic function (increased acetylcholinesterase activity), increased inflammation (more myeloperoxidase) and mitochondrial dysfunction (reduced complex I, II and IV activity). (rjptonline.org)
  • Neuroprotective activity of tetramethylpyrazine against 3-nitropropionic acid induced Huntington's disease-like symptoms in rats. (rjptonline.org)
  • 4. A combination of SK&F 94836 (10(-5) M) and forskolin (5 x 10(-8) M) significantly augmented glucose-induced insulin secretion (30% increase), although neither drug alone, in these concentrations, produced any significant effect. (strath.ac.uk)
  • Quorum sensing is a type of bacterial communication that occurs via the secretion of autoinducer molecules (5). (kenyon.edu)
  • Said and Mutt named the peptide vasoactive intestinal polypeptide and also showed that it stimulated pancreatic bicarbonate secretion in the cat although was only 5-10% as potent as secretin (63). (pancreapedia.org)
  • Papaverine has also been demonstrated to be a selective phosphodiesterase inhibitor for the PDE 10A subtype found mainly in the striatum of the brain. (cloudfront.net)
  • 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure. (guidetopharmacology.org)
  • Guellich A, Mehel H, Fischmeister R. (2014) Cyclic AMP synthesis and hydrolysis in the normal and failing heart. (guidetoimmunopharmacology.org)
  • Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid. (nature.com)
  • Sharma S, Kumar K, Deshmukh R, Sharma PL. (2013) Phosphodiesterases: Regulators of cyclic nucleotide signals and novel molecular target for movement disorders. (guidetoimmunopharmacology.org)
  • Interleukin-31 (IL-31), a cytokine released from T cells (especially, CD4 + -Th2 cells), signals through a receptor complex comprising IL-31RA and oncostatin M receptor β (OSMRβ) (4, 5). (medicaljournals.se)
  • A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. (umassmed.edu)
  • In addition, AMP treatment block TGF- ß1/Smads pathway inhibited the production of ECM and alleviates liver fibrosis. (bvsalud.org)
  • 2011) Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions. (guidetoimmunopharmacology.org)
  • Cyclic AMP apparently plays an important role in maintaining PF-04979064 meiotic arrest PF-04979064 in mammalian oocytes. (immune-source.com)
  • Nonadrenergic, noncholinergic relaxations were elicited by field stimulation (1-16 Hz, 1 msec, 8 V for 15 sec) of guinea pig trachea desensitized with capsaicin (3 microM), pretreated with atropine (1 microM), propranolol (1 microM), indomethacin (3 microM) and treated with alpha-chymotrypsin (2 U/ml) and contracted with 3 microM histamine. (unboundmedicine.com)
  • β1-adrenergic amines, histamine H2 agonists, 5 HT1 agonists and polypeptide hormones stimulate Gs protein. (remixeducation.in)
  • However, many severe pruritic diseases, except acute urticaria, respond poorly to H 1 histamine receptor antagonists (1-3). (medicaljournals.se)
  • GC42622 8-bromo-Cyclic AMP 8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase. (glpbio.cn)
  • 3-nitropropionic acid (3-NP), an inhibitor of succinate dehydrogenase develops behavioral, biochemical as well as histological alterations in the striatal region of brain, which resembles HD in humans. (rjptonline.org)
  • AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. (cusabio.com)
  • The infectious dose of V. cholerae is between 10^5 −10^8 organisms for humans (1). (kenyon.edu)
  • Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution. (ox.ac.uk)
  • EC 3.1.4.17 , 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35 , 3,5-cyclic-GMP phosphodiesterase). (enzyme-database.org)
  • Caffeine acts directly on adipose cells, promoting lipolysis, inhibiting phosphodiesterase, and thus augmenting cyclic AMP. (celiraz-europe.com)
  • Influence of glutamate, dopamine and 5-hydroxytryptamine on calcium efflux from locust foregut and hindgut visceral muscle. (biologists.com)
  • D. Glick is the author of Methods of Biochemical Analysis ( avg rating, 1 rating, 0 reviews, published ), Methods of Biochemical Analysis ( av 4/5(1). (pitbikemoravia.cz)
  • This book, Methods of Soi/Analysis: Chemical Methods, is Part 3 of SSSA Book Series No. Biochemical analysis techniques Biochemical analysis techniques refer to a set of methods, assays, and procedures that enable scientists to analyze the substances found in living organisms and the chemical reactions underlying life processes. (pitbikemoravia.cz)
  • Pesticide Biochemistry and Physiology (1983) 20 (3): 278. (biologists.com)
  • Comparative Biochemistry and Physiology Part A: Physiology (1982) 71 (3): 425. (biologists.com)
  • Biochemistry 5 (1966) 150-157. (qmul.ac.uk)
  • Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors. (ox.ac.uk)
  • Release of phosphodiesterase activator from particulate fractions of cerebellum and striatum by putative neurotransmitters. (wikidata.org)
  • Activator of cGMP-dependent protein kinases I α, I β & type II and cGMP-gated ion channels (cyclic GMP agonist). (biolog.de)
  • Forskolin, an activator of adenylate cyclase, was used to examine the regulation of [3H]acetylcholine (ACh) release by cyclic AMP (cAMP)-related mechanisms in myenteric plexus-longitudinal muscle preparations of guinea pig small intestine. (aspetjournals.org)
  • 3. Mehan S, Parveen S, Kalra S. Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders. (rjptonline.org)
  • American Journal of Physiology-Cell Physiology (1981) 240 (5): C239. (biologists.com)
  • Cyclic Nucleotide Phosphodiesterases, Type 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 7" by people in this website by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 7" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 7" by people in Profiles. (umassmed.edu)
  • Evidence for expression and function of phosphodiesterase type 5 (PDE-V) in rat resistance arteries. (ox.ac.uk)