Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.
A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.
Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.
Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2'- or 3'- phosphate bonds of 2',3'-cyclic nucleotides. Also hydrolyzes nucleoside monophosphates. Includes EC 3.1.4.16 and EC 3.1.4.37. EC 3.1.4.-.
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
A phosphodiesterase 4 inhibitor with antidepressant properties.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own tissue localization. The isoforms are encoded by at least two genes and are a product of multiple alternative splicing of their mRNAs.
A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
An anti-inflammatory 9-fluoro-glucocorticoid.
Compounds that specifically inhibit PHOSPHODIESTERASE 4.
Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.
... cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3',5'-cyclic ... Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): ... Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399-405. PMID ... cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320-5. doi:10.1038/sj.ijir ...
cAMP's role in this process terminates upon hydrolysis to AMP by phosphodiesterase. Cyclic nucleotides are well-suited to act ... The two most well-studied cyclic nucleotides are cyclic AMP (cAMP) and cyclic GMP (cGMP), while cyclic CMP (cCMP) and cyclic ... where it stimulates a protein kinase called cyclic AMP-dependent protein kinase. By phosphorylating proteins, cyclic AMP- ... Lincoln, TM; Cornwell TL (1991). "Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth ...
Winchurch, R., Hait, W. and Weiss, B.: Cyclic AMP phosphodiesterase activity of murine T and B lymphocytes. Cell. Immunol. 41: ... 7. Uzunov, P., Shein, H.M. and Weiss, B.: Cyclic AMP phosphodiesterase in cloned astrocytoma cells: norepinephrine induces a ... Strada, S.J. and Weiss, B.: Increased response to catecholamines of the cyclic AMP system of rat pineal gland induced by ... He is best known for his work with cyclic nucleotide phosphodiesterases. He was the first to propose, based on his experimental ...
"Ontogenic development of a phosphodiesterase activator and the multiple forms of cyclic AMP phosphodiesterase of rat brain". ... A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic ... "Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase". Advances in Cyclic ... as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases ...
... cyclic-AMP phosphodiesterase Phosphodiesterase (PDE) PDE4 inhibitor This article includes a list of related items that share ... At least four types of the enzyme phosphodiesterase 4 (PDE4) are known: PDE4A PDE4B PDE4C PDE4D 3',5'- ...
Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats; An Torremans, Abdellah ... 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): 671-80. doi:10.1067/mai ... A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), ... Fertel R, Weiss B (1976). "Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung". Mol. ...
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Biology ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3',5'-GMP phosphodiesterase, cyclic guanosine 3',5'- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3',5'-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate ...
... and it is long-acting because it is resistant to degradation by cyclic AMP phosphodiesterase. 8-Bromoguanosine 3',5'-cyclic ... is a brominated derivative of cyclic adenosine monophosphate (cAMP). 8-Br-cAMP is an activator of cyclic AMP-dependent protein ... cyclic monophosphate at Sigma-Aldrich 8-Bromo Cyclic Adenosine Monophosphate at PubChem. ...
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP+phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso GD, ...
"Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP". The ... Helfman DM, Kuo JF (Jan 1982). "A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- ... Nov 2003). "Structural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase ... selectively activates the calcium-calmodulin sensitive isoform of cyclic nucleotide phosphodiesterase from human myometrium". ...
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase. cAMP is a second messenger, used for intracellular ... such as cyclic adenosine monophosphate, cyclic AMP). Cyclic AMP is synthesized from ATP by adenylate cyclase located on the ... Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in ... Since cyclic AMP is a second messenger and plays vital role in cell signalling, it has been implicated in various disorders but ...
Denis D, Riendeau D (February 1999). "Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 ... Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN ... Osinski MT, Schrör K (August 2000). "Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 ... 367 (2-3): 343-50. doi:10.1016/S0014-2999(98)00987-X. PMID 10079010. Media related to Quazinone at Wikimedia Commons. ...
Chapter 33 in Cyclic Nucleotide Phosphodiesterases in Health and Disease, Eds Joseph A. Beavo et al. CRC Press, Dec 5, 2006 ... Hannila SS, Filbin MT (Feb 2008). "The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury ... Nov 2012). "Phosphodiesterases as therapeutic targets for Alzheimer's disease". ACS Chem Neurosci. 3 (11): 832-44. doi:10.1021/ ... Apr 2013). "Phosphodiesterase 4-targeted treatments for autoimmune diseases". BMC Med. 11 (1): 96. doi:10.1186/1741-7015-11-96 ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... alkylglycerophosphoethanolamine phosphodiesterase activity. • macromolecular complex binding. Cellular component. • ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.[5] ... This gene uses alternative polyadenylation signals.[5][6] Interactive pathway map[edit]. Click on genes, proteins and ...
Gαs activates the cAMP-dependent pathway by stimulating the production of cyclic AMP (cAMP) from ATP. This is accomplished by ... An example is adenylate cyclase, which produces the second messenger cyclic AMP.[6] For this discovery, they won the 1994 Nobel ... which produces the second messenger cyclic AMP.[6]. *The 1988 Nobel Prize in Physiology or Medicine to George H. Hitchings, Sir ... cyclic-GMP phosphodiesterase. *Protein kinase G. *G alpha subunit Gα *GNAO1 ...
cAMP phosphodiesterase converts cAMP into AMP by breaking the phosphodiester bond, in turn reducing the cAMP levels ... Kaupp UB, Seifert R (July 2002). "Cyclic nucleotide-gated ion channels". Physiol. Rev. 82 (3): 769-824. CiteSeerX 10.1.1.319. ... caffeine and theophylline inhibit cAMP phosphodiesterase, which degrades cAMP - thus enabling higher levels of cAMP than would ... bucladesine (dibutyryl cAMP, db cAMP) - also a phosphodiesterase inhibitor. *pertussis toxin, which increases cAMP levels by ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... doi:10.1016/S0969-2126(01)00259-3. PMID 8591034.. *^ Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble ... 9 (1): 22-3. doi:10.4161/cc.9.1.10735. PMID 20016257.. *^ Baumann K (November 2013). "Cell cycle: Cyclin A corrections". Nature ... cyclin D 1,2,3 (Cdk4, Cdk6) cyclin E (Cdk2) cyclin A (Cdk2, Cdk1) cyclin B (Cdk1) ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ...
Cyclic GMP-AMP (cGAMP) is a cyclic dinucleotide (CDN) and the first to be found in metazoans. Other CDNs (c-di-GMP and c-di-AMP ... phosphodiesterases. Other advantages of the unique 2'-5' linkage may be that cGAMP is able to bind multiple allelic variants of ... Upon binding DNA, the protein cyclic GMP-AMP Synthase (cGAS) triggers reaction of GTP and ATP to form cyclic GMP-AMP (cGAMP). ... specifically by the cyclic-GMP-AMP synthase (cGAS). Upon DNA recognition, cGAS dimerizes and stimulates the formation of cyclic ...
PDE4 hydrolyzes cyclic adenosine monophosphate (cAMP) to inactive adenosine monophosphate (AMP). Inhibition of PDE4 blocks ... Moustafa, F; Feldman, SR (16 May 2014). "A Review of Phosphodiesterase-Inhibition and the Potential Role for Phosphodiesterase ... is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a ... "Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor". British Journal of ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on ... Because RETGC-1 produces cGMP, which keeps cyclic nucleotide-gated channels open allowing the influx of calcium, this mutation ... doi:10.1007/978-3-540-68964-5_2.. *^ Tseng K, Caballero A, Dec A, Cass D, Simak N, Sunu E, Park M, Blume S, Sammut S, Park D, ...
... cyclic AMP 3',5'-cyclic dAMP 3',5'-cyclic IMP 3',5'-cyclic GMP 3',5'-cyclic CMP There are 11 distinct phosphodiesterase ... 3'5'-cyclic nucleotide phosphodiesterases are a family of phosphodiesterases. Generally, these enzymes hydrolyze some ... monophosphate phosphodiesterase (cyclic CMP), cyclic 3',5-nucleotide monophosphate phosphodiesterase, nucleoside 3',5'-cyclic ... Kroll S, Phillips WJ, Cerione RA (March 1989). "The regulation of the cyclic GMP phosphodiesterase by the GDP-bound form of the ...
... cyclic-AMP phosphodiesterase. *Protein kinase A. cGMP:. *Transducin. *Gustducin. *Guanylate cyclase ... 244 (20): 5763-, 5. PMID 4310608.. *^ Takeuchi M, Yanagida M (1993). "A mitotic role for a novel fission yeast protein kinase ... A major target of Akt kinases is glycogen synthase kinase-3. EC 2.7.1.37 Pelle. is a serine/threonine kinase that can ... Langan TA (1969). "Action of adenosine 3',5'-monophosphate-dependent histone kinase in vivo". J. Biol. Chem. ...
Zhang HT (2009). "Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs". Current ... Némoz G, Zhang R, Sette C, Conti M (Apr 1996). "Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene ... "Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification ... "Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)". Gene. 138 (1-2): 253-6. doi: ...
... for instance a bond in a molecule of cyclic AMP or cyclic GMP. An enzyme that plays an important role in the repair of ... Phosphodiesterase Phosphodiesterase inhibitor DNA replication, DNA, ATP Teichoic acid, DNase I PDE5 Nick (DNA) "Phosphodiester ... A phosphodiesterase is an enzyme that catalyzes the hydrolysis of phosphodiester bonds, ... Hydrolysis of phosphodiester bonds is catalyzed by phosphodiesterases, which are involved in repairing DNA sequences. The ...
Lugnier, C. (2006). "Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific ... into AMP and GMP. These second messengers control many physiological processes. The cAMP is formed from ATP by the enzyme ... Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine ... Phosphodiesterase 5 (PDE5) is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder ...
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic ... The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a ... "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family". Gene. 129 (2): 239-47. doi: ... "Entrez Gene: PDE4B phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)". Swerdlow, Neal R. ( ...
Dransfield DT, Bradford AJ, Smith J, Martin M, Roy C, Mangeat PH, Goldenring JR (Jan 1997). "Ezrin is a cyclic AMP-dependent ... "mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module". The EMBO Journal. 20 (8): 1921-30. doi: ... Beebe SJ, Salomonsky P, Holroyd C, Becker D (Dec 1993). "Differential expression of cyclic AMP-dependent protein kinase ... "Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and ...
The activated OR in turn activates the intracellular G-protein, GOLF (GNAL), adenylate cyclase and production of cyclic AMP ( ... CaMKII will also activate phosphodiesterase, which will then hydrolyze cAMP. The effect of this negative feedback response ... "Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons". Proc ... 21 (3): 495-504. doi:10.1016/s0896-6273(00)80561-9. PMID 9768837. S2CID 9860137. Yan, C; Zhao, AZ; Bentley, JK; Loughney, K; ...
... an effect mediated by decreased cyclic AMP-mediated phosphorylation-activation of the enzyme.[25] α2 receptors also cause ... Cashman JR, Ghirmai S (October 2009). "Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase ... decreased intracellular cyclic AMP expression which results in smooth muscle relaxation or decreased secretion.[26] TCAs ... 292 (5): R1775-81. doi:10.1152/ajpregu.00527.2006. PMID 17218444.. *^ a b Morishita S, Arita S (February 2003). "The clinical ...
... which is necessary for lipid mobilization in response to cyclic AMP, which itself is provided by the activation of Gs protein- ... 53 (5): 1110-7. doi:10.1095/biolreprod53.5.1110. PMID 8527515.. *^ Langin D, Laurell H, Holst LS, Belfrage P, Holm C (June 1993 ... 130 (3): 697-705. PMC 1174508. PMID 4664927.. *^ de Meijer J (1998-05-01). "Hormone sensitive lipase: structure, function and ... Hormone-sensitive lipase (EC 3.1.1.79, HSL), also previously known as cholesteryl ester hydrolase (CEH),[5] sometimes referred ...
Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of ... B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, ... B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, ... "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta ...
... is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its ... Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP ... cyclic GMP; Guanosine cyclic monophosphate; Cyclic 3',5'-GMP; Guanosine 3',5'-cyclic phosphate ... Phosphodiesterase inhibitors prevent the degradation of cGMP, thereby enhancing and/or prolonging its effects. For example, ...
Phosphodiesterase quickly converts cAMP to AMP, thus reducing the amount of cAMP that can activate protein kinase A. PKA is ... Cyclic+AMP-Dependent+Protein+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) ... The regulatory subunit has domains to bind to cyclic AMP, a domain that interacts with catalytic subunit and an auto inhibitory ... cyclic AMP)-dependent protein kinase was discovered by chemists Edmond H. Fischer and Edwin G. Krebs in 1968. They won the ...
Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... These signals then can be terminated by cAMP phosphodiesterase, which is an enzyme that degrades cAMP to 5'-AMP and inactivates ... via adenylate cyclase and cyclic AMP (cAMP). In a feedback mechanism, these activated kinases phosphorylate the receptor. The ... The effector of both the Gαs and Gαi/o pathways is the cyclic-adenosine monophosphate (cAMP)-generating enzyme adenylate ...
Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology. 108 (5): ... "Phosphodiesterase-9 (PDE9) inhibition with BAY 73-6691 increases corpus cavernosum relaxations mediated by nitric oxide-cyclic ... Studies have found that Paraxanthine is a phosphodiesterase type 9 (PDE9) inhibitor[13] and It's sold as a research molecule ... PDE9 is a cGMP preferring phosphodiesterase and It's expressed in corpus cavernosum as high as PDE5 is.[15] ...
2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID ... AMP (cAMP) • UMP • GMP (cGMP) • CMP • ADP • UDP (m5UDP) • GDP • CDP • ATP • UTP • GTP • CTP ... the effects of non-specific phosphodiesterase inhibition". Clinics (São Paulo). 63 (3): 321-8. doi:10.1590/S1807- ... dAMP • dTMP • dUMP • dGMP • dCMP • dADP • dTDP • dUDP • dGDP • dCDP • dATP • dTTP • dUTP (m5UTP) • dGTP • dCTP ...
Essayan DM (2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555 ... competitive nonselective phosphodiesterase inhibitor,[19] which raises intracellular cAMP, activates PKA, inhibits TNF-alpha[20 ... 33 (3): 3035-3056. doi:10.1002/cber.19000330352.. *^ Minkowski O (1902). "Über Theocin (Theophyllin) als Diureticum". Ther. ... 28 (3): 3139. doi:10.1002/cber.189502803156.. *^ Traube W (1900). "Der synthetische Aufbau der Harnsäure, des Xanthins, ...
PDE4 is an isoenzyme that hydrolyzes cyclic AMP to regulate human bronchial tone (along with PDE3). Yet as a PDE4 inhibitor, ... 29 (5): 399-401. PMID 15706885.. *^ Morteza-Semnani, K; Amin, G; Shidfar, MR; Hadizadeh, H; Shafiee, A (2003). "Antifungal ... 17 (5): 521-4. doi:10.1111/j.1365-2125.1984.tb02384.x. PMC 1463443 . PMID 6375709.. ... It has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker,[5] and is used ...
... an effect mediated by decreased cyclic AMP-mediated phosphorylation-activation of the enzyme.[29] α2 receptors also cause ... Cashman JR, Ghirmai S (October 2009). "Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase ... decreased intracellular cyclic AMP expression which results in smooth muscle relaxation or decreased secretion.[30] ... doi:10.1016/s0924-977x(02)00057-3. PMID 12208564.. *^ a b Stahl SM, Grady MM, Moret C, Briley M (September 2005). "SNRIs: their ...
2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID ... Theobromine is weaker in both its inhibition of cyclic nucleotide phosphodiesterases and its antagonism of adenosine receptors. ... 24] The potential inhibitory effect of theobromine on phosphodiesterases is seen only at amounts much higher than what people ... Its effect as a phosphodiesterase inhibitor[22] is thought to be small.[1] ...
2001). "Cyclic nucleotide phosphodiesterases". J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID ... competitive nonselective phosphodiesterase inhibitors [10] which raise intracellular cAMP, activate PKA, inhibit TNF-α [9][11] ... Xanthine (/ˈzænθiːn/ or /ˈzænθaɪn/; archaically xanthic acid) (3,7-dihydropurine-2,6-dione), is a purine base found in most ... 3,7-Dihydro-purine-2,6-dione. Plants, animals Caffeine. CH3. CH3. CH3. H. 1,3,7-Trimethyl-1H-purine-2,6(3H,7H)-dione. Coffee, ...
The cyclic AMP-regulatory dimers are degraded by phosphodiesterase and release 5'AMP. DNA in the cell nucleus binds to ... Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain coming from the G protein (that was ... via adenylate cyclase and cyclic AMP (cAMP). These protein kinases are present as tetramers with two regulatory units and two ... phosphorylated proteins through the cyclic AMP response element (CRE), which results in the activation of genes.[5] ...
Holden CA, Chan SC, Norris S, Hanifin JM (1988). "Histamine induced elevation of cyclic AMP phosphodiesterase activity in human ... svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7) ... CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan ... B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2) ...
... the ectonucleotide pyrophosphatase/phosphodiesterases (E-NPPs) and alkaline phosphatases (APs). Extracellular AMP is hydrolyzed ... for sustained platelet aggregation through the inhibition of adenylate cyclase and a corresponding decrease in cyclic adenosine ... Renal interstitial adenosine is mainly derived from dephosphorylation of released ATP, AMP, or cAMP by the enzyme ecto-5′- ... AMP or 5′-IMP to adenosine or inosine, respectively, and is located primarily on the external membranes and mitochondria of ...
1975). "Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis". Adv Cyclic ... van Calker D, Müller M, Hamprecht B (1978). "Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells". Nature ... The PDE2 (phosphodiesterase 2) enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs ... cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism" (PDF). Gen Physiol Biophys. 22 ...
Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A (February 1987). "Inhibitors of cyclic AMP phosphodiesterase. 1. ... The exact mechanism of action is unclear, although it is known to be a phosphodiesterase inhibitor. It is a potent (IC50 = 36nM ... Phosphodiesterase inhibitor with antiplatelet activity. Condensation of benzyl chloride 1 with ethyl ester of glycine gives ... inhibitor of phosphodiesterase-II.[citation needed] It inhibits PDE-3 and phospholipase A2. ...
"A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase". Nat. Cell Biol. 3 (11): 1020-4. PMID ... "Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B ... Así mesmo é activada polos receptores acoplados á proteína G(s) ADRB2, PTGER1 e CHRM3 por medio da formación de AMP cíclico e ... 5,0 5,1 5,2 5,3 5,4 "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1". Consultado o 23 de outubro de 2011. ...
... adenylate cyclase and production of cyclic AMP (cAMP) opens ion channels in the cell membrane, resulting in an influx of sodium ... CaMKII will also activate phosphodiesterase, which will then hydrolyze cAMP.[11] The effect of this negative feedback response ... 5 (3): 243-66. doi:10.1023/A:1008826827728. PMID 9663551.. *^ Saladin, Kenneth (2012). Anatomy & physiology : the unity of form ... The axons of olfactory receptor cells which express the same OR converge to form glomeruli in the olfactory bulb.[5] ...
... phosphodiesterase E1 dunce homolog, Drosophila)". Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for ... Sullivan M, Olsen AS, Houslay MD (2000). "Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene ... cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene. PDE4C is predominantly found in ... 2001). "Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H] ...
... cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, ... cyclic-AMP+phosphodiesterase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania ... cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. Alonso GD, ...
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. ... Catalyzes the hydrolysis of both cAMP and cGMP to 5-AMP and 5-GMP, respectively (By similarity). ... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: UniProtKB. *cyclic-nucleotide phosphodiesterase activity ... cyclic-AMP and -GMP phosphodiesterase 11AAdd BLAST. 933. Amino acid modifications. Feature key. Position(s). DescriptionActions ...
Cyclic-AMP Phosphodiesterases" by people in Profiles.. * Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin ... Cyclic-AMP Phosphodiesterases" by people in this website by year, and whether "3,5-Cyclic-AMP Phosphodiesterases" was a major ... Cyclic-AMP Phosphodiesterases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5-phosphate. The enzymes are widely distributed in animal ...
Cyclic-AMP Phosphodiesterases" by people in this website by year, and whether "3,5-Cyclic-AMP Phosphodiesterases" was a major ... Cyclic-AMP Phosphodiesterases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5-phosphate. The enzymes are widely distributed in animal ... tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate ...
Cyclic-AMP Phosphodiesterases" by people in Profiles.. * Hajjhussein H, Suvarna NU, Gremillion C, Chandler LJ, ODonnell JM. ... Cyclic-AMP Phosphodiesterases" by people in this website by year, and whether "3,5-Cyclic-AMP Phosphodiesterases" was a major ... Cyclic-AMP Phosphodiesterases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5-phosphate. The enzymes are widely distributed in animal ...
2002 Feb 15;46(3):278-86. Research Support, Non-U.S. Govt; Research Support, U.S. Govt, P.H.S. ... cyclic AMP phosphodiesterase from Escherichia coli encoded by the cpdA gene does not show any homology to either PDE class I or ... Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of enzymes that were previously divided by their primary ... Cyclic nucleotide phosphodiesterases class III: members, structure, and catalytic mechanism.. Richter W1. ...
A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability.. J. Biol. Chem. 284 32846 ... In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP ... cyclic nucleotide phosphodiesterase: biochemical and mutational analysis.. Biochemistry 44 15695-704 2005 ... Identification of the cpdA gene encoding cyclic 3,5-adenosine monophosphate phosphodiesterase in Escherichia coli.. J. Biol. ...
... cyclic-AMP phosphodiesterase activity Source: GO_Central ,p>Inferred from Biological aspect of Ancestor,/p> ,p>A type of ... cyclic AMP degradation. This protein is involved in step 1 of the subpathway that synthesizes AMP from 3,5-cyclic AMP.. ... Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.Curated. Phylogenomic databases. evolutionary ... cyclic phosphodiesterase 7BAdd BLAST. 450. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
We have identified and characterised a novel member of the PDE7 family of cyclic nucleotide phosphodiesterases (PDE), which we ... Cyclic-AMP Phosphodiesterases * Cyclic Nucleotide Phosphodiesterases, Type 7 * PDE7A protein, human ... Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase Biochem ... We have identified and characterised a novel member of the PDE7 family of cyclic nucleotide phosphodiesterases (PDE), which we ...
... cyclic-AMP phosphodiesterase activity IBA Inferred from Biological aspect of Ancestor. more info ... cyclic GMP-inhibited phosphodiesterase B. cyclic nucleotide phosphodiesterase. phosphodiesterase 3B, cGMP-inhibited. NP_ ... PDEase_I; 35-cyclic nucleotide phosphodiesterase. pfam06532. Location:136 → 282. DUF1109; Protein of unknown function ( ... PDEase_I; 35-cyclic nucleotide phosphodiesterase. pfam06532. Location:136 → 282. DUF1109; Protein of unknown function ( ...
Roflumilast is a new phosphodiesterase 4 (PDE4) inhibitor developed by Byk Gulden Pharmaceuticals for the treatment of chronic ... Cyclic-AMP Phosphodiesterases / antagonists & inhibitors* * 3,5-Cyclic-AMP Phosphodiesterases / metabolism ... The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exercise-induced asthma and leads to suppression of LPS- ... Roflumilast is a new phosphodiesterase 4 (PDE4) inhibitor developed by Byk Gulden Pharmaceuticals for the treatment of chronic ...
Cyclic AMP. 60-92-4. C10H12N5O6P. 329.2059. 329.052519653. Not Available. ... Cyclic GMP. 7665-99-8. C10H12N5O7P. 345.2053. 345.047434275. Not Available. ... 7732-18-5. H2O. 18.0153. 18.010564686. Not Available. HMDB0001397. Guanosine monophosphate. 85-32-5. C10H14N5O8P. 363.2206. ... C10H14N5O7P. 347.2212. 347.063084339. Not Available. ...
Cyclic AMP. 60-92-4. C10H12N5O6P. 329.2059. 329.052519653. Not Available. ... Cyclic GMP. 7665-99-8. C10H12N5O7P. 345.2053. 345.047434275. Not Available. ... Rundfeldt C, Socala K, Wlaz P: The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is ... 7732-18-5. H2O. 18.0153. 18.010564686. Not Available. HMDB0001397. Guanosine monophosphate. 85-32-5. C10H14N5O8P. 363.2206. ...
... cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd. J. Bacteriol. ... Cyclic nucleotides, cyclic nucleotide phosphodiesterase, and development in Myxococcus xanthus. Can. J. Microbiol. 24:1475-1484 ... Sequential changes in the cyclic nucleotide levels and cyclic phosphodiesterase activities during development of M. xanthus. ... cyclic AMP, AMP, ADP and nutrition. Proc. Natl. Acad. Sci. USA 72:518-522. ...
Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]. *Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.150 ... Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]. *Cyclic Nucleotide Phosphodiesterases, Type 5 [D08.811.277.352.640.155 ... A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular ... Novel Mechanism for Cyclic Dinucleotide Degradation Revealed by Structural Studies of Vibrio Phosphodiesterase V-cGAP3. J Mol ...
... cyclic-AMP phosphodiesterase activity / metal ion binding. Processes. cAMP catabolic process / signal transduction / synaptic ... cyclic phosphodiesterase 7B. Synonyms. *3.1.4.53. Gene Name. PDE7B. Organism. Humans. Amino acid sequence. ,lcl,BSEQ0010437, ... a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun. 2000 May 27;272(1):186-92. [PubMed: ... Sasaki T, Kotera J, Yuasa K, Omori K: Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res ...
Cyclic AMP and cyclic GMP phosphodiesterase". Biochim. Biophys. Acta. 334: 368-377. doi:10.1016/0005-2744(74)90180-6. Biology ... phosphate phosphodiesterase, cyclic GMP phosphodiesterase, cyclic 3,5-GMP phosphodiesterase, cyclic guanosine 3,5- ... phosphate phosphodiesterase, cGMP phosphodiesterase, cGMP-PDE, and cyclic guanosine 3,5-phosphate phosphodiesterase. As of ... cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3,5-cyclic phosphate ...
The enzyme is widely distributed in animal tissue and controls the level of intracellular cyclic AMP. Also acts on 3,5-cyclic ... An enzyme that catalyzes the hydrolysis of cyclic AMP to form adenosine 5-phosphate. ... Cyclic Nucleotide Phosphodiesterases, Type 1 Cyclic Nucleotide Phosphodiesterases, Type 2 Cyclic Nucleotide Phosphodiesterases ... Cyclic Nucleotide Phosphodiesterases, Type 4 Cyclic Nucleotide Phosphodiesterases, Type 5 Cyclic Nucleotide Phosphodiesterases ...
... cyclic-AMP phosphodiesterase activity / cAMP binding / ion channel binding / metal ion binding ... The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family. Gene. 1993 Jul 30;129(2):239- ... Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. J Mol Biol. 2004 ... Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H: Structures of the four subfamilies of phosphodiesterase-4 ...
... cyclic AMP phosphodiesterase {ECO:0000256,HAMAP-Rule:MF_00905}; DE Short=cAMP phosphodiesterase {ECO:0000256,HAMAP-Rule:MF_ ... cyclic-AMP phosphodiesterase activity; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR ... cyclic AMP + H2O = AMP + H(+); CC Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:58165, ChEBI:CHEBI ... cyclic adenosine monophosphate phosphodiesterase CpdA {ECO:0000256,HAMAP-Rule:MF_00905}; DE Short=3,5- ...
... cyclic-AMP and -GMP phosphodiesterase 11A. *EC 3.1.4. *EC 3.1.4.17 ... Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp ... cAMP and cGMP cyclic nucleotide phosphodiesterase 11A. *cAMP ...
It is enzymatically produced by diadenylate cyclase and cleaved by c-di-AMP phosphodiesterase. c-di-AMP is believed to be ... It is enzymatically produced by diadenylate cyclase and cleaved by c-di-AMP phosphodiesterase. c-di-AMP is believed to be ... two distinct Streptococcus mutans phosphodiesterases involved in the pathway producing AMP from c-di-AMP, were investigated. ... two distinct Streptococcus mutans phosphodiesterases involved in the pathway producing AMP from c-di-AMP, were investigated. ...
Cyclic AMP. A Possible Role of the Pancreatic α1 and α2-Cells as Local Regulators of Insulin Secretion. Intestinal Hormones and ... Biochemical, Pharmacological, and Physiological Aspects of the Adenylcyclase-Phosphodiesterase System in the Pancreatic ß-Cells ... Feedback Regulation of Insulin Secretion by Insulin: Role of 3,5- ...
... cyclic AMP: step 1/1.. * Sequence similarities. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. ... High affinity cAMP specific and IBMX insensitive 35 cyclic phosphodiesterase 8A. *High affinity cAMP-specific and IBMX- ... May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. ... cyclic AMP degradation; AMP from 3,5- ... Weakly similar to 35 cyclic nucleotide phosphodiesterase. see ...
... cyclic AMP: step 1/1.. * Sequence similarities. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. ... cyclic AMP degradation; AMP from 3,5- ... phosphodiesterase 4A cAMP specific. *Phosphodiesterase 4A, cAMP ...
... cyclic-AMP) uses effector proteins to influence cell function and fate.1 The synthesis and degradation of cyclic-AMP are ... it was unclear how cyclic-AMP inhibited PI3K activity. Further investigation showed that cyclic-AMP, in a PDE4B-dependent ... In nonneoplastic models, cyclic-AMP is known to attenuate vessel development.28⇓⇓-31 To address the contribution of PDE4B ... Here, we review a decade-long exploration of the contribution of cyclic-AMP and PDE4 to the pathogenesis of B-cell lymphoma,5⇓⇓ ...
... cyclic-AMP phosphodiesterase activity *[MF] cGMP binding *[MF] calcium- and calmodulin-regulated 3,5-cyclic-GMP ... MF] calmodulin-dependent cyclic-nucleotide phosphodiesterase activity *[MF] hydrolase activity *[MF] metal ion binding ...
Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of ... cyclic-AMP phosphodiesterase involved in cAMP-mediated signaling; cellular location unknown. View computational annotations ... PhosphoDiEsterase 1 Comparative Info. Integrated model organism details available at the Alliance of Genome Resources website ... the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation 1 2 3 4 5 Name Description. ...
High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell ... cyclic-AMP phosphodiesterase involved in cAMP-mediated signaling; localizes to nucleus and cytoplasm in high-throughput studies ... PhosphoDiEsterase 5 Comparative Info. Integrated model organism details available at the Alliance of Genome Resources website ... from extracellular cAMP, contains readthrough motif surrounding termination codon 1 2 3 4 Name Description. ...
  • 3',5' Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of enzymes that were previously divided by their primary structure into two major classes: PDE class I and II. (nih.gov)
  • The 3',5' cyclic AMP phosphodiesterase from Escherichia coli encoded by the cpdA gene does not show any homology to either PDE class I or class II enzymes and, therefore, represents a new, third class of PDEs. (nih.gov)
  • 1 The synthesis and degradation of cyclic-AMP are tightly controlled by 2 classes of enzymes, adenylyl cyclases and phosphodiesterases (PDEs), respectively. (bloodjournal.org)
  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). (genecards.org)
  • Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). (creativebiomart.net)
  • Cyclic nucleotide hydrolyzing phosphodiesterases (PDEs), which comprise a large superfamily of 11 families termed PDE1-PDE11 ( 13 , 14 ), play a fundamental role in regulating T cell signaling. (jimmunol.org)
  • Phosphodiesterase isozymes (PDEs) are integral factors in determining cellular content and accumulation of cGMP, and up-regulation of PDE activity could participate in the glomerular resistance to ANP in severe CHF. (elsevier.com)
  • Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). (reactome.org)
  • 1. The cyclic nucleotide phosphodiesterases (PDEs) present in an insulin secreting cell line, BRIN - BD11, were characterized using calcium/calmodulin, IGF-1, isoenzyme-selective PDE inhibitors and RT - PCR. (strath.ac.uk)
  • 8 These and other studies 9,10 also underlined the importance of cAMP phosphodiesterases (PDEs) for the spatiotemporal control of cAMP signals. (ahajournals.org)
  • X-ray cocrystal structures of certain PDEs and catalytic products (5′-GMP or 5′-AMP) contain these bonds (in PDE11A4, Gln-869 would be the contact amino acid), but cocrystal structure of a PDE with a CN has not been determined. (aspetjournals.org)
  • Are Phosphodiesterase-5 Inhibitors a New Frontier for Prevention of Colorectal Cancer? (harvard.edu)
  • 2 , 3 The therapeutic utility of controlling the intracellular levels of cyclic-AMP, and of cyclic guanosine monophosphate (cyclic-GMP), with PDE inhibitors is well established. (bloodjournal.org)
  • and (3) preserved in the presence of inhibitors of protein kinase A and inositol-1,4,5-triphosphate receptors. (ahajournals.org)
  • Background: Phosphodiesterase 4 (PDE4) inhibitors negatively modulate many inflammatory responses, and some of these pharmacological effects are mediated by inhibition of PDE4B in inflammatory cells. (thefreelibrary.com)
  • sup][5] By increasing intracellular cAMP level, phosphodiesterase 4 (PDE4) inhibitors are being developed as anti-inflammatory agents for the treatment of chronic inflammatory disorders such as asthma, chronic obstructive pulmonary disease, and psoriasis. (thefreelibrary.com)
  • The phosphodiesterase inhibitors milrinone, CI-930, UK-35,493, carbazeran and buquineran acted as potent inhibitors of cyclic AMP hydrolysis catalysed by both PDE-II and PDE-III enzymes. (strath.ac.uk)
  • Cyclic peptide libraries have successfully been employed for the identification of inhibitors of highly challenging targets. (bioportfolio.com)
  • These nucleosides act as nonhydrolyzable cyclic AMP mimetics and are reported to be potent inhibitors of rat brain phosphodiesterase. (nii.ac.jp)
  • We designed new bicyclic-sugar adenosines, as potential phosphodiesterase inhibitors, which can be synthesized via Diels-Alder reactions of certain nucleoside-dienes and dienophiles such as methyl acrylate. (nii.ac.jp)
  • Poor understanding of the topography of cyclic nucleotide (CN) phosphodiesterase (PDE) catalytic sites compromises development of potent, selective inhibitors for therapeutic use. (aspetjournals.org)
  • Guanosine 3',5'-cyclic phosphate + H 2 O = guanosine 5'-phosphate. (uniprot.org)
  • In enzymology, a 3',5'-cyclic-GMP phosphodiesterase (EC 3.1.4.35) is an enzyme that catalyzes the chemical reaction guanosine 3',5'-cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } guanosine 5'-phosphate Thus, the two substrates of this enzyme are guanosine 3',5'-cyclic phosphate and H2O, whereas its product is guanosine 5'-phosphate. (wikipedia.org)
  • Cyclic dimeric guanosine 3′,5′-monophosphate (c-di-GMP), a signaling molecule that acts as a secondary messenger, is important for control of biofilm formation, adhesion, motility, virulence, and cell morphogenesis ( Boyd and O'Toole, 2012 ). (frontiersin.org)
  • One important second messenger in transducing the regulable nature of motile cilia is cyclic guanosine 3′,5′-monophosphate (cGMP). (mdpi.com)
  • IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate. (mpbio.com)
  • Guanosine cyclic 3',5'-(hydrogen phosphate). (hmdb.ca)
  • This enzyme catalyses the following chemical reaction adenosine 3',5'-cyclic phosphate + H2O ⇌ {\displaystyle \rightleftharpoons } AMP This enzyme requires Mg2+ or Mn2+ for activity. (wikipedia.org)
  • The present study shows by computational analysis that the enzyme encoded by the E. coli cpdA gene belongs to a family of phosphodiesterases that closely resembles the catalytic machinery known from purple acid phosphatases and several other dimetallophosphoesterases. (nih.gov)
  • This enzyme hydrolyses cAMP to 5'-AMP. (ebi.ac.uk)
  • The systematic name of this enzyme class is 3',5'-cyclic-GMP 5'-nucleotidohydrolase. (wikipedia.org)
  • The enzyme is widely distributed in animal tissue and controls the level of intracellular cyclic AMP. (termsciences.fr)
  • Caffeine competitively inhibits phosphodiesterase, the enzyme that degrades cyclic 3'- 5' adenosine monophosphate. (nih.gov)
  • PDE4A and PDE4D mRNAs as well as enzyme activities were up-regulated within 5 days, PDE4B showed a transient up-regulation with highest levels after 24 h. (jimmunol.org)
  • This enzyme increases cyclic adenosine 3 ', 5'-monophosphate (c AMP) in thrombocytes and smooth muscle cells decreasing intracellular calcium with consequent relaxation and vasodilation. (scielo.br)
  • We therefore evaluated the role of phosphoinositide 3-kinase (PI3K) and p42/p44 mitogen-activated protein kinase (p42/p44 MAPK) pathways in regulating this enzyme. (strath.ac.uk)
  • 1. An assay has been developed with sufficient sensitivity for determination of the adenosine 3′:5′-cyclic monophosphate diesterase activity in islets of Langerhans, and has been used to investigate the response of the enzyme to various agents which are known to affect insulin release. (portlandpress.com)
  • Cyclic AMP is produced from ATP by the enzyme adenylate cyclase (AC) and is hydrolyzed by cyclic AMP phosphodiesterases. (moleculardevices.com)
  • A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. (uams.edu)
  • I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. (miami.edu)
  • A prime example of this is an enzyme called 3,5- cyclic nucleotide phosphodiesterase (cAMP-PDE) that converts cyclic Adenosine Monophosphate (cAMP) into non-cyclic Adenosine Monophosphate (AMP). (madsci.org)
  • When caffeine or another methylxanthine is applied to a cell, it inhibits the activity of cAMP-PDE by binding to the site of the enzyme that usually binds the adenine of cAMP, such that cAMP-PDE can no longer convert cAMP to AMP. (madsci.org)
  • Cyclic dimeric adenosine 3′,5′-monophosphate (c-di-AMP), a recently identified secondary messenger in bacteria, plays a role in several bacterial processes, including biofilm formation. (frontiersin.org)
  • Phosphodiesterase 4 (PDE4) inhibition restores the suppressive effects of 3′,5′-cyclic adenosine monophosphate in lymphocytes. (bloodjournal.org)
  • The second messenger 3′,5′-cyclic adenosine monophosphate (cyclic-AMP) uses effector proteins to influence cell function and fate. (bloodjournal.org)
  • Here we report a novel role for epinephrine and cyclic adenosine monophosphate (cAMP) in the regulation of human SS RBC adhesiveness via the laminin receptor, basal cell adhesion molecule/Lutheran (BCAM/Lu). (bloodjournal.org)
  • Elevation of the second messenger cyclic adenosine monophosphate (cAMP) in macrophages suppresses several inflammatory responses, including inflammatory mediator production and receptor-mediated phagocytosis. (thefreelibrary.com)
  • The ultimate fate of cAMP is its transformation into AMP by the cleavage of the phosphodiester bond by 3', 5'-cyclic adenosine monophosphate phosphodiesterase [9] . (proteopedia.org)
  • The role of adenosine 3′:5′-cyclic monophosphate in the regulation of insulin release. (portlandpress.com)
  • The phosphodiesterase activity in the peak fraction showed two apparent K m values for adenosine 3′:5′-cyclic monophosphate (cyclic AMP) of 3μ m and 30μ m , suggesting the presence of two activities. (portlandpress.com)
  • The mode of action of adenosine 3′:5′-cyclic monophosphate in mammalian islets of Langerhans. (portlandpress.com)
  • Adenosine 3´, 5´-cyclic monophosphate (cyclic AMP, cAMP) is a universal secondary messenger that connects changes in the extracellular environment, as detected by cell surface receptors, to changes in the nucleus, which results in altered patterns of gene expression. (moleculardevices.com)
  • Lysine vasopressin (antidiuretic hormone), like cyclic adenosine 3',5'-monophosphate (cyclic AMP), rapidly (in less than 1 hour) stimulates the initiation of deoxyribonucleic acid synthesis and thereby increases the flow of cells into mitosis in rat thymic lymphocyte populations in vitro. (dtic.mil)
  • IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. (mpbio.com)
  • c-di-AMP Control, also known as 5'-pApA, is a linear dinucleotide analog that can be obtained after hydrolysis of cyclic diadenylate monophosphate (c-di-AMP) by phosphodiesterases [1]. (invivogen.com)
  • PDE8B degrades cyclic adenosine monophosphate (cAMP), a second messenger involved in dopamine signaling. (cdc.gov)
  • Roflumilast is a new phosphodiesterase 4 (PDE4) inhibitor developed by Byk Gulden Pharmaceuticals for the treatment of chronic obstructive pulmonary disease and asthma. (nih.gov)
  • In this concise review, we detail how PDE4 inhibition downmodulates the B-cell receptor (BCR)-related kinases spleen tyrosine kinase and phosphatidylinositol 3-kinase and inhibits vascular endothelial growth factor A secretion by tumor cells, inducing cancer cell apoptosis and blocking angiogenesis in the microenvironment. (bloodjournal.org)
  • Here, we review a decade-long exploration of the contribution of cyclic-AMP and PDE4 to the pathogenesis of B-cell lymphoma, 5 ⇓ ⇓ ⇓ - 9 culminating with the first-in-cancer clinical trial of a PDE4 inhibitor in advanced B-cell malignancies. (bloodjournal.org)
  • 6 Mechanistically, PDE4 inhibition resulted in elevation of intracellular cyclic-AMP levels and suppression of PI3K and AKT activity. (bloodjournal.org)
  • 6 These data linked the cyclic-AMP/PDE4 axis to the essential tonic BCR signals, highlighting the potential impact of PDE4 modulation in malignant B cells ( Figure 1 ). (bloodjournal.org)
  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. (genecards.org)
  • Type 4 phosphodiesterases (PDE4) are critical regulators in TCR signaling by attenuating the negative constraint of cAMP. (jimmunol.org)
  • 3. The PDE1/PDE5 inhibitor zaprinast inhibited both cyclic AMP and cyclic GMP PDE activity in both pellet and supernatant fractions of cell homogenates by a maximum of around 25% (IC(50) 1 - 5 microM), while rolipram (PDE4 selective) inhibited only cyclic AMP hydrolysis. (strath.ac.uk)
  • Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD (2003) Beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. (springer.com)
  • In addition, the availability of atomic coordinates for several purple acid phosphatases and related proteins allowed the generation of a three-dimensional model for class III cyclic nucleotide phosphodiesterases. (nih.gov)
  • A tBLASTn search of the Myxococcus xanthus genome database at The Institute for Genomic Research (TIGR) identified three genes ( pdeA , pdeB , and pdeC ) that encode proteins homologous to 3′,5′-cyclic nucleotide phosphodiesterase. (asm.org)
  • Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. (proteopedia.org)
  • AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. (proteopedia.org)
  • Results: Three proteins were identified, of which the proinflammatory chemokine CC chemokine ligand 3 (CCL3) and cytokine TNF-a were downregulated and the antiinflammatory cytokine interleukin-1 receptor antagonist was upregulated. (thefreelibrary.com)
  • sup][5] The cAMP effectors protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac) are thought to mediate these inhibitory effects. (thefreelibrary.com)
  • In rat cerebral homogenates ZK 62711 inhibits soluble and particulate cyclic AMP phosphodiesterases but is less potent with respect to cyclic GMP phosphodiesterases. (aspetjournals.org)
  • Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLATE CYCLASE and cyclic AMP. (nih.gov)
  • Also inhibits cGMP phosphodiesterases. (mpbio.com)
  • Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils. (uchicago.edu)
  • Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Ia Oxidation. (harvard.edu)
  • The second messenger cAMP has been recognized as an important mediator of such inhibitory signaling mechanisms by activation of the cAMP-protein kinase A (PKA), 3 with PKA functioning as a gatekeeper of tonic inhibition in T cells ( 5 , 6 , 7 , 8 , 9 , 10 ). (jimmunol.org)
  • Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. (proteopedia.org)
  • Nicotinamide has demonstrated anti-inflammatory actions that may be of benefit in patients with acne including, but not limited to, suppression of antigen-induced lymphocytic transformation and inhibition of 3',5'- cyclic AMP phosphodiesterase. (nih.gov)
  • IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). (mpbio.com)
  • The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. (mpbio.com)
  • Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45. (illumina.com)
  • Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. (childrensmercy.org)
  • The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. (childrensmercy.org)
  • Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP. (childrensmercy.org)
  • Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. (creativebiomart.net)
  • 1971). The specific distribution of cyclic AMP in various brain regions reflects the relative activities of the synthetic and degradative enzymes, adenyl cyclase, and phosphodiesterase. (springer.com)
  • In solution, the C 1a and C 2a domains can form heterodimers with each other, either in the same or different enzymes, or they can form homodimers with their identical units on different enzymes [3] . (proteopedia.org)
  • Such enzymes include, but are not limited to, adenylyl cyclase (AC) for synthesis of cyclic AMP (cAMP), guanylyl cyclase for synthesis of cyclic GMP (cGMP), cyclic nucleotide phosphodiesterase (PDE) for hydrolysis of cAMP and cGMP, and phospholipase C (PLC) for hydrolysis of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate (IP 3 ) and DAG. (ahajournals.org)
  • Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. (uniprot.org)
  • 5. It is suggested that the agents theophylline, caffeine, SC-2964, glibenclamide, tolbutamide, leucine and imidazole may alter the intracellular concentration of cyclic AMP in islets of Langerhans by affecting the cyclic AMP phosphodiesterase activity in islet cells and in this way may affect insulin release. (portlandpress.com)
  • 16) have shown that the concentration of cyclic 3',5'-AMP increases in frog muscle after E administration. (aspetjournals.org)
  • Gene Ontology (GO) annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity . (genecards.org)
  • On the other hand, vasopressin's mitogenic action (also like that of cyclic AMP) is blocked by imidazole, an activator of cyclic nucleotide phosphodiesterase activity. (dtic.mil)
  • A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. (harvard.edu)
  • Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity. (nih.gov)
  • Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes. (nih.gov)
  • Human phosphodiesterase 3A has been used in a study to assess its role for the unique 44-amino acid insert. (creative-enzymes.com)
  • Human phosphodiesterase 3A has also been used in a study to investigate this gene's expression using a baculovirus expression system in insect cells. (creative-enzymes.com)
  • Furthermore, the known biochemical properties of the bacterial phosphodiesterase encoded by the cpdA gene, such as the requirement of iron ions and a reductant for maintaining its catalytic activity, support this hypothesis developed by computational analysis. (nih.gov)
  • 42 , 43 Cyclic-AMP (cAMP) downmodulates this positive signaling wave by suppressing SYK and PI3Kδ activity. (bloodjournal.org)
  • PDE hydrolyzing activity of both cAMP and cGMP were higher in the glomerular homogenates obtained from the kidneys of the CHF group (N = 5) compared to those of the control group (N = 5). (elsevier.com)
  • AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). (proteopedia.org)
  • Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. (proteopedia.org)
  • 2. Calmodulin activated cyclic AMP or cyclic GMP PDE activity in pellet and was 3 fold (P=0.002) more potent in activating cyclic nucleotide hydrolysis in pellet compared with supernatant fractions. (strath.ac.uk)
  • This was shown using SKF94836 (PDE3 inhibitor) which maximally inhibited membrane-bound cyclic AMP PDE activity by approximately 25-30% and by RT-PCR. (strath.ac.uk)
  • Cyclic AMP is a ubiquitous cellular second messenger that is a critical component of a signal transduction pathway linking membrane receptors and their ligands to the activation of internal cellular enzymatic activity and gene expression. (biomol.com)
  • Steady-state activation of cardiac β-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide phosphodiesterase (PDE) activity. (ahajournals.org)
  • Ahmad F, Shen W, Vandeput F, Szabo-Fresnais N, Krall J, Degerman E, Goetz F, Klussmann E, Movsesian M, Manganiello V (2015) Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2. (springer.com)
  • A gene on chromosome 5q12 that encodes a counterpart of the fruit fly "dunce" gene, which has 3',5'-cyclic-AMP phosphodiesterase activity and hydrolyses the second messenger cAMP to AMP, thereby playing a role in regulating physiological processes. (thefreedictionary.com)
  • 3. Gel filtration of the activity present in the supernatant fraction on Sephadex G-200 gave a single peak of activity with an apparent molecular weight of 200000. (portlandpress.com)
  • The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. (creativebiomart.net)
  • Extraction of frozen canine cardiac muscle rendered soluble over 90% of the cyclic AMP phosphodiesterase activity. (strath.ac.uk)
  • Ion exchange chromatography of the soluble activity on DE-52 allowed for the resolution of three distinct cyclic AMP phosphodiesterase fractions termed PDE-I, PDE-II and PDE-III in order of elution from the column by a linear NaCl gradient. (strath.ac.uk)
  • The relative ratio of cyclic AMP phosphodiesterase activity exhibited by these three peaks was 1:0.65:0.82 and of cyclic GMP phosphodiesterase activity was 1:0.52:0.05 for PDE-I, PDE-II and PDE-III respectively. (strath.ac.uk)
  • The extracellular receptor stimulated kinase ERK2 (p42(MAPK))-phosphorylated human cAMP-specific phosphodiesterase PDE4D3 at Ser579 and profoundly reduced ( approximately 75%) its activity. (hw.ac.uk)
  • Amino acids critical for the activity of the parent cyclic peptide were uncovered using alanine-scanning, and a series of non-natural analogues synthesized and assessed. (bioportfolio.com)
  • This work further demonstrates the relative simplicity with which the potency and activity of cyclic peptides identified from SICLOPPS libraries can be optimized. (bioportfolio.com)
  • c-AMP-phosphodiesterase activity in fat body & testes of male rats & effect of aspirin on the same. (bvsalud.org)
  • These bicyclic-sugar nucleosides were deprotected and tested against dog phosphodiesterase III.However, none of these showed potent inhibitory activity. (nii.ac.jp)
  • 3',5'-Cyclic-AMP Phosphodiesterases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are, differentially expressed and regulated in rat tissue. (creativebiomart.net)
  • Udani et al 5 have demonstrated that the basal cell adhesion molecule and its isoform Lutheran (BCAM/Lu) are the major RBC receptors for laminin under basal conditions. (bloodjournal.org)
  • This compound belongs to the class of organic compounds known as 3',5'-cyclic purine nucleotides. (hmdb.ca)
  • Caffeine is a methylxanthine (1,3,7-trimethylxanthine to be exact), which is a modified purine. (madsci.org)
  • Therefore, the concentration of cAMP in a cell is a function of the ratio of the rate of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by specific phosphodiesterases. (biomol.com)
  • Gardner C, Robas N, Cawkill D, Fidock M: Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. (drugbank.ca)
  • Phosphodiesterase 7A, a cAMP-specific phosphodiesterase, has been shown to affect memory, T-cell functioning and emesis and has been implicated in depression. (mybiosource.com)
  • 92 phosphodiesterase 4A, CAMP-Specific (PDE4A) Antibodies from 14 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • 5 The association between high PDE4B expression and poor DLBCL outcome was subsequently confirmed in larger independent series. (bloodjournal.org)
  • ABHD15 associates with and stabilizes phosphodiesterase 3B (PDE3B). (nih.gov)
  • Data indicate that genome-wide significant associations were found both at age 6 and 14 with single nucleotide polymorphisms (SNPs) on chromosome 11p15 in phosphodiesterase 3B, cGMP-inhibited protein PDE3B/cytochrome P-450 CYP2R1 genes. (nih.gov)
  • PDE3B (Phosphodiesterase 3B) is a Protein Coding gene. (genecards.org)
  • 7. These findings, in a clonal insulin secreting cell line, are consistent with an important role for PDE3B in regulating the pool of cyclic AMP relevant to the modulation of glucose-induced insulin secretion. (strath.ac.uk)
  • We report here that the cyclic GMP-inhibited cyclic AMP specific phosphodiesterase (PDE3B) is expressed as a membrane-bound protein in clonal insulin-secreting BRIN-BD11 cells. (strath.ac.uk)
  • We propose that the deregulation of the PI3K/PDE3B pathway might result in increased intracellular cyclic AMP accumulation, which promotes apoptosis. (strath.ac.uk)
  • A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: implication for vascular control. (nih.gov)
  • Intracellular cyclic AMP (cAMP) levels of pdeA or pdeB mutant cells under these stressful conditions were about 1.3-fold to 2.0-fold higher than those of wild-type cells. (asm.org)
  • A cAMP phosphodiesterase gene ( cpdA )-disrupted Escherichia coli or Salmonella enterica serovar Typhimurium strain showed about 2- or 1.3-fold higher intracellular cAMP than the wild-type strain, respectively ( 2 , 6 ). (asm.org)
  • This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 5" by people in Harvard Catalyst Profiles by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 5" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 5" by people in Profiles. (harvard.edu)
  • Analysis of short-term treatment with the phosphodiesterase type 5 inhibitor tadalafil on long bone development in young rats. (harvard.edu)
  • Upregulation of Phosphodiesterase type 5 in the Hyperplastic Prostate. (harvard.edu)
  • Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis. (bioportfolio.com)
  • X-ray crystal structure of pactamide G () sets an example for resolving the absolute configuration of 5/5/6 type PoTeMs. (bioportfolio.com)
  • When it was found that the antibiotic rapamycin was a potent inhibitor of the proliferation of virtually every eukaryotic cell type examined (e.g., fungi, T cells, and tumor cells) [ 1 , 2 , 3 ], it became clear that the molecular target of rapamycin must be highly conserved and its function critical for cell survival. (mdpi.com)
  • Indeed, the presence of subcellular compartments with different cAMP concentrations, also called cAMP microdomains, are inferred from L-type Ca 2+ channel current ( I Ca,L ) measurements in response to local β-AR stimulation in cardiomyocytes 5 and by direct monitoring of cAMP using fluorescence resonance energy transfer (FRET)-based sensors 6,7 or cyclic nucleotide-gated (CNG) channels. (ahajournals.org)
  • CDNs including c-di-AMP bind the cytosolic DNA sensor STING (stimulator of interferon genes) and induce the production of type I interferons (IFNs). (invivogen.com)
  • Due to its linear conformation, 5'-pApA is intended to serve as a negative control for c-di-AMP in type I IFN induction assays. (invivogen.com)
  • The inability of c-di-AMP Control to induce type I interferon (IFN) has been confirmed in THP1-Blue™ ISG cells. (invivogen.com)
  • Representatives of the six complementation groups previously identified ( stmA-stmF ) were found to be similar to the parental wild-type strain XP55 in both the extent and timing of their ability to initiate and relay chemotactic signals and in the formation of cyclic AMP receptors and phosphodiesterases. (microbiologyresearch.org)
  • The degradation of cAMP is achieved by 3′,5′-cyclic nucleotide phosphodiesterases, which catalyze cleavage of 3′,5′-cAMP to 5′-cAMP. (asm.org)
  • Novel Mechanism for Cyclic Dinucleotide Degradation Revealed by Structural Studies of Vibrio Phosphodiesterase V-cGAP3. (harvard.edu)
  • This mitogenic action of vasopressin, again like that of cyclic AMP, is potentiated by caffeine, an inhibitor of the intracellular phosphodiesterase which catalyzes the degradation of cyclic AMP. (dtic.mil)
  • Rennard SI, Schachter N, Strek M, Rickard K, Amit O. Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4. (uchicago.edu)
  • On the other hand, cilostazol is a potent and selective inhibitor of phosphodiesterase III. (scielo.br)
  • At low concentrations it is 100 times more potent than a structurally related phosphodiesterase inhibitor, Ro 20-1724, with respect to the calcium-dependent cyclic AMP phosphodiesterase, and in brain slices it is similarly 100 times more potent in enhancing accumulations of cyclic AMP elicited by norepinephrine. (aspetjournals.org)
  • Cyclic GMP acted as a potent inhibitor (IC50 = 6.3 microM) of cyclic AMP hydrolysis catalysed by PDE-III but not of the hydrolysis of cyclic AMP by PDE-II (IC50 = 33.2 microM). (strath.ac.uk)
  • Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures. (uchicago.edu)
  • Previous studies have shown that adenosine 3´, 5´cyclic monophosphoric acid (cyclic AMP) is a key factor in the regulation of narcosis [1]. (springer.com)
  • Bacterial second messengers, including cyclic dimeric nucleotides, are molecules that control important signaling cascades in bacteria and their hosts during infection ( Pesavento and Hengge, 2009 ). (frontiersin.org)
  • It was of interest to determine whether the dibutyryl analog of cyclic AMP and other adenine nucleotides regulate conduction anesthesia as well. (springer.com)
  • SIMILARITY: Belongs to the cAMP phosphodiesterase class-III CC family. (univ-lyon1.fr)
  • Belongs to the cyclic nucleotide phosphodiesterase family. (abcam.com)
  • In the current study, the biochemical and biological roles of GdpP (SMU_2140c) and DhhP (SMU_1297), two distinct Streptococcus mutans phosphodiesterases involved in the pathway producing AMP from c-di-AMP, were investigated. (frontiersin.org)
  • The cAMP signal is neutralized by hydrolysis of cAMP to AMP by phosphodiesterases. (biomol.com)
  • β 3 -AR function was observed with NOR and ISO when β 1 -/β 2 -ARs were blocked and with both β 3 -selective agonists in NOR-treated cells only. (aspetjournals.org)
  • AKT1_HUMAN ] AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. (proteopedia.org)
  • This list of 582 genes contains 12 proteases and 3 antiproteases. (biomedcentral.com)
  • The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. (ebi.ac.uk)
  • Caffeine (1,3,7-trimethylpurine-2,6-dione) has a number of biochemical actions. (hindawi.com)
  • A new class of inhibitor of phosphodiesterases is represented by 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711). (aspetjournals.org)
  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. (genecards.org)
  • We, therefore, first determined cGMP generation in response to particulate and soluble guanylyl cyclase activation by ANP and sodium nitroprusside (SNP) in isolated glomeruli from normal (N = 6) and CHF dogs (N = 5) in which CHF was induced by rapid ventricular pacing for 18 to 28 days. (elsevier.com)
  • The lipid soluble, phosphodiesterase-resistant 6-N, 2-0, dibutyryl analog of cyclic AMP (db-cyclic AMP) when administered intracerebroventricularly, dose-dependently shortened narcosis induced by amobarbital [2] and a wide variety of anesthetic, sedative-hypnotic, and tranquilizer agents [3]. (springer.com)
  • Structure of dog adenylyl cyclase 5 (grey), rat adenylyl cyclase 2 (green), bovine guanine nucleotide-binding protein subunit α (pink) complex with ADP derivative (stick model), GDP derivative (stick model), methylpiperazinoforskolin, Ca+2, Mg+2 and Cl- ions (PDB code 3maa ). (proteopedia.org)
  • Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. (proteopedia.org)
  • Bjorgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Tasken K (2010) Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. (springer.com)
  • Expression of the cpdA gene, encoding a 3',5'-cyclic AMP (cAMP) phosphodiesterase, is positively regulated by the cAMP-cAMP receptor protein complex. (bio-protocol.org)
  • Bolger G, Michaeli T, Martins T, St John T, Steiner B, Rodgers L, Riggs M, Wigler M, Ferguson K: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. (drugbank.ca)