A class of opioid receptors recognized by its pharmacological profile. Kappa opioid receptors bind dynorphins with a higher affinity than endorphins which are themselves preferred to enkephalins.
A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)
A class of opioid receptors recognized by its pharmacological profile. Delta opioid receptors bind endorphins and enkephalins with approximately equal affinity and have less affinity for dynorphins.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Inorganic compounds that contain ruthenium as an integral part of the molecule.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Compounds based on benzeneacetamide, that are similar in structure to ACETANILIDES.
A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered a specific antagonist to etorphine.
A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
A disulfide opioid pentapeptide that selectively binds to the DELTA OPIOID RECEPTOR. It possesses antinociceptive activity.
Agents inhibiting the effect of narcotics on the central nervous system.
A group of DITERPENES cyclized into 2-rings with a side-chain.
Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.
Organic compounds which contain platinum as an integral part of the molecule.
A fatty acid that is found in plants and involved in the formation of prostaglandins.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Morphine derivatives of the methanobenzazocine family that act as potent analgesics.
Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
Compounds containing the PhCH= radical.
One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.
Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.
The study of the composition, chemical structures, and chemical reactions of the NERVOUS SYSTEM or its components.
A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Endogenous amino acids released by neurons as excitatory neurotransmitters. Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory transmitter for many years, but the extent of its role as a transmitter is unclear.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
Cell surface proteins that bind amino acids and trigger changes which influence the behavior of cells. Glutamate receptors are the most common receptors for fast excitatory synaptic transmission in the vertebrate central nervous system, and GAMMA-AMINOBUTYRIC ACID and glycine receptors are the most common receptors for fast inhibition.
Drugs that bind to and activate excitatory amino acid receptors.
A neuronal and epithelial type glutamate plasma membrane transporter protein.
A glial type glutamate plasma membrane transporter protein found predominately in ASTROCYTES. It is also expressed in HEART and SKELETAL MUSCLE and in the PLACENTA.
A glutamate plasma membrane transporter protein found in ASTROCYTES and in the LIVER.
... cyclohexyl)-benzeneacetamide, (trans)-isomer MeSH D03.383.773.342 - glycopyrrolate MeSH D03.383.773.371 - imino furanoses MeSH ... methyl ester MeSH D03.383.725.210 - dimethindene MeSH D03.383.725.220 - 2,2'-dipyridyl MeSH D03.383.725.227 - disopyramide MeSH ... methyl ester MeSH D03.383.725.547.950 - xanthinol niacinate MeSH D03.383.725.565 - nicotinyl alcohol MeSH D03.383.725.592 - ... 2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ...
... cyclohexyl)-benzeneacetamide Monohydrochloride, (trans)-(+-)-Isomer,. *trans-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)- ... cyclohexyl)-benzeneacetamide, (trans)-Isomer" by people in Profiles.. * Behavioral Pharmacology of Novel Kappa Opioid Receptor ... cyclohexyl)-benzeneacetamide, (trans)-Isomer" by people in Harvard Catalyst Profiles by year, and whether "3,4-Dichloro-N- ... cyclohexyl)-benzeneacetamide, (trans)-Isomer*3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)- ...
... cyclohexyl)-benzeneacetamide: A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release ... pyrrolidinyl)- cyclohexyl)- benzeneacetamide. Subscribe to New Research on (trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1- ... cyclohexyl)-benzeneacetamide, (trans)-(-)-Isomer; U-50,488H; U-50488; U-50488H; U50488H; trans-3,4-Dichloro-N-methyl-N-(2-(1- ... cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Mesylate ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer * Enkephalin, D-Penicillamine (2,5)- Grant support * DE08973/DE/NIDCR NIH HHS/ ... K A Sutters 1 , C Miaskowski, Y O Taiwo, J D Levine ... cyclohexyl)-benzeneacetamide, (trans)-Isomer * Analgesics, ... Enkephalin, Ala(2)-MePhe(4)-Gly(5)- * 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)- ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer / pharmacology* * Analysis of Variance * Animals * Cardiotonic Agents / ... After 30 minutes of left coronary occlusion and 2-hour reperfusion, opioid delta-receptor agonist DADLE significantly decreased ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ... 2-hour) mortality by 22% and 19% respectively. The above opioid delta- and kappa-receptor cardiac effects were abolished by the ...
2 w: 2 wk hypoxia; 2 w+NS: 2 w+normal saline; 2 w+U50: 2 w+U50,488H; 2 w+U50+nor-BNI ... cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology*/therapeutic use. *Anoxia/complications*. *Endothelium, Vascular/drug ... 2 w; ττP,0.01 vs. 2 w+NS; $P,0.05 vs. 2 w+U50. Mentions: The data presented above indicate that U50,488H can stimulate ... pone-0060850-g006: Effect of U50,488H on T-AOC in pulmonary arteries of HPH rats.Con: control; 2 w: 2 wk hypoxia; 2 w+NS: 2 w+ ...
... cyclohexyl)-benzeneacetamide, (trans)-isomer MeSH D03.383.773.342 - glycopyrrolate MeSH D03.383.773.371 - imino furanoses MeSH ... methyl ester MeSH D03.383.725.210 - dimethindene MeSH D03.383.725.220 - 2,2-dipyridyl MeSH D03.383.725.227 - disopyramide MeSH ... methyl ester MeSH D03.383.725.547.950 - xanthinol niacinate MeSH D03.383.725.565 - nicotinyl alcohol MeSH D03.383.725.592 - ... 2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 - 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ...
trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide Medicine & Life Sciences 100% ... cyclo-hexyl]-benzeneacetamide) methanesulfonate hydrate (U-50,488H; 10-7 to 2x10-5 M) had a concentration-dependent negative ... cyclo-hexyl]-benzeneacetamide) methanesulfonate hydrate (U-50,488H; 10-7 to 2x10-5 M) had a concentration-dependent negative ... cyclo-hexyl]-benzeneacetamide) methanesulfonate hydrate (U-50,488H; 10-7 to 2x10-5 M) had a concentration-dependent negative ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer *Glycopyrrolate *Imino Furanoses *kainic acid *levetiracetam *Lincosamides * ... 1-ring 5-member heterocyclic compounds ⌊Alchemy Center. ⌊Chemical Entities. ⌊Organic Compounds. ⌊Organoheterocyclic compound ... 1-ring 5-member heterocyclic compounds. "1-ring 5-member heterocyclic compounds" 1-ring 5-member heterocyclic compounds are ... pyrrolizines (a fused 2-ring 5-5 heterocyclics) *Pyrrolidinones *Cotinine *Doxapram *Oxotremorine *Piracetam *Povidone * ...
CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER. D04 - POLYCYCLIC HYDROCARBONS. HTLV-BLV VIRUSES. DELTARETROVIRUS. ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer Entry term(s). Benzeneacetamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl) ... cyclohexyl)-benzeneacetamide Monohydrochloride, (trans)-(+-)-Isomer, Entry term(s). trans-3,4-Dichloro-N-methyl-N-(2-(1- ... pyrrolidinyl)-cyclohexyl)-benzeneacetamide Hydrochloride 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)- ... cyclohexyl)-benzeneacetamide, (trans)-(-)-Isomer. Benzeneacetamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, ( ...
... cyclohexyl)-benzeneacetamide, (trans)-(-)-Isomer .. U-50,488H .. U-50488 .. U-50488H .. U50488H .. trans-3,4-Dichloro-N-methyl- ... cyclohexyl)-benzeneacetamide, (trans)-Isomer .. Terms. Synonyms & Historicals. Documents. LILACS e MDLcyclohexyl)-benzeneacetamide, (trans)-Isomer .. 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide ... cyclohexyl)-benzeneacetamide Mesylate, (trans)-(+-)-Isomer .. 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)- ...
2009 Feb;34(3):775-85. doi: 10.1038/npp.2008.142. Epub 2008 Sep 17. Research Support, Non-U.S. Govt ... cyclohexyl)-benzeneacetamide, (trans)-Isomer. *Dynorphins. *Corticotropin-Releasing Hormone. *preproenkephalin. *Corticosterone ... Figure 1. Ambulation in the open field was assessed over 10 min for dyn(+/+) and dyn(−/−) mice. Dyn(−/−) mice more often ... Figure 4. Time spent immobile did not differ between dyn(+/+) and dyn(−/−) mice in the first and last trial of the repeated ...
1998 May;56(1-2):281-3. Comparative Study; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, P.H.S. ... cyclohexyl)-benzeneacetamide, (trans)-Isomer/administration & dosage. *Animals. *Enkephalin, D-Penicillamine (2,5)- ... Roy S1, Liu HC, Loh HH.. Author information. 1. Department of Pharmacology, University of Minnesota Medical School, Minneapolis ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ...
... cyclohexyl)-benzeneacetamide, (trans)-IsomerAnalgesicsAnalgesics, OpioidAnimalsAutopsyBenzamidesCalibrationChromatography, ... cyclohexyl)-N-methylbenzamide). Both drugs have been reported to be present in the heroin supply and to be gaining popularity ... cyclohexyl)-N-methylbenzamide). Both drugs have been reported to be present in the heroin supply and to be gaining popularity ... The analytical range for U-47770 and U-50488 was 1-500 and 1-100 ng/mL for furanyl fentanyl. The limit of detection was 0.5 ng/ ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer, pharmacology, Animals, Binding, Competitive, drug effects, Disease Models, Animal ... 11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain.. 1998 A C Robson et al. Molecular Brain ... 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, administration & dosage, pharmacology, Animals, Brain, Corpus ... Unilateral labyrinthectomy downregulates glutamate receptor delta-2 expression in the rat vestibulocerebellum.. 1998 T Kitahara ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2010 Type: ... cyclohexyl)-benzeneacetamide, (trans)-Isomer Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2010 Type: ... cyclohexyl)-benzeneacetamide, (trans)-Isomer , Pharmacology , Animals , Benzophenanthridines , Pharmacology , Connexin 43 , ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer / MAP Kinase Signaling System Language: Chinese Journal: Chinese Journal of ... cyclohexyl)-benzeneacetamide, (trans)-Isomer / MAP Kinase Signaling System Language: Chinese Journal: Chinese Journal of ... cyclohexyl)-benzeneacetamide, (trans)-Isomer , Pharmacology , Animals , Animals, Newborn , Cardiomegaly , Metabolism , Cells, ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer. *Anisomycin. *Bepridil. *Clemastine. *Glycopyrrolate. *Imino Furanoses ... 2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer. *Anisomycin. *Bepridil. *Clemastine. *Glycopyrrolate. *Imino Furanoses ... Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis. J Hepatol. 2017 08 ... of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or ... and Safety of Glecaprevir/Pibrentasvir in Patients Coinfected With Hepatitis C Virus and Human Immunodeficiency Virus Type 1: ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer * Animals * Animals, Inbred Strains - Rats, Inbred Strains ... July 1, 1988 has subject area * 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)- ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer - Receptors, Opioid, delta オピオイド受容体-デルタ ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer ; Animals ; Injections, Intraventricular ; Ligands ; Pyrrolidines/chemistry ; Rats ... 410-1.. Typ publikacji :. Journal Article. MeSH Terms :. Narcotics/*metabolism Receptors, Opioid/*metabolism. Animals ; Brain ... 380-1.. Typ publikacji :. Journal Article. MeSH Terms :. Buprenorphine/*pharmacology Cocaine/*pharmacology Diprenorphine/* ... 130-2.. Typ publikacji :. Biography; Historical Article; Journal Article; Portrait. MeSH Terms :. Biochemistry/history ; ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer. *Anisomycin. *Bepridil. *Clemastine. *Glycopyrrolate. *Imino Furanoses ... A randomized phase 2 network trial of tivantinib plus cetuximab versus cetuximab in patients with recurrent/metastatic head and ... A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (From Merck ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology , Naphthalenes - pharmacology , Dose-Response Relationship, Drug , ... 4. Full Text Activation of adenosine A2A receptors suppresses the emission of pro-social and drug-stimulated 50-kHz ultrasonic ... 3. Full Text Mechanisms of Locomotor Sensitization to Drugs of Abuse in a Two-Injection Protocol ... 2. Full Text Inhibitory Inputs from Rostromedial Tegmental Neurons Regulate Spontaneous Activity of Midbrain Dopamine Cells and ...
... cyclohexyl)-benzeneacetamide, (trans)-Isomer * Animals * Buprenorphine / pharmacology * Chlorides / pharmacology * Cocaine / ... 1 Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan. ... 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer ...
  • In cardiac myocyte suspensions U-50,488H and leucine enkephalin both caused a rapid and sustained increase in inositol 1,4,5-trisphosphate. (elsevier.com)
  • Cells were field-stimulated at 1 Hz in 1.5 mM bathing Ca 2+ at 23°C. The μ-agonist [D-Ala 2 ,N-Me-Phe 4 ,Gly 5 -ol]-enkephalin (10 -5 M) had no effect on the twitch. (elsevier.com)
  • In myocytes loaded with the Ca 2+ probe indo-1, the effects of leucine enkephalin (10 -8 M) and U-50,488H (10 -5 M) on the twitch were associated with similar directional changes in the Ca(i) transient. (elsevier.com)
  • and the recently proposed "cross talk" between beta (1)-adrenergic and opioid receptors in cardiac myocytes (involving inhibition of adenylate cyclase by G(I/o) proteins). (nih.gov)
  • Phenylethanolamine N-methyltransferase gene expression: synergistic activation by Egr-1, AP-2 and the glucocorticoid receptor. (naver.com)
  • The present invention resides in the discovery that glucocorticoid receptor antagonists are effective for treating muscular dystrophy including type 1 or type 2 myotonic dystrophy. (sumobrain.com)
  • 2. The method of claim 1, wherein the patient is administered a composition consisting essentially of a glucocorticoid receptor antagonist in an amount effective to ameliorate the symptoms of the muscular dystrophy. (sumobrain.com)
  • 5. The method of claim 1, wherein the glucocorticoid receptor antagonist comprises a steroidal skeleton with at least one phenyl-containing moiety in the 1 l -β position of the steroidal skeleton. (sumobrain.com)
  • 8. The method of claim 6, wherein the glucocorticoid receptor antagonist is selected from the group consisting of 1 1 P-(4-dimethylaminoethoxyphenyl)-l 7a-propynyl- l 7β- hydroxy-4,9 estradien-3-one and 17P-hydroxy- 17a-19-(4-methylphenyl)androsta-4,9( l l )-dien-3~ one. (sumobrain.com)
  • 10. The method of claim 1, wherein the glucocorticoid receptor antagonist is (1 1 β,17β)-1 l -(l ,3-benzodioxol-5-yl)-17-hydroxy- 17-(l -propynyl)estra-4,9-dien-3-one. (sumobrain.com)
  • 11. The method of claim 1, wherein the glucocorticoid receptor antagonist is administered once per day. (sumobrain.com)
  • 13. The method of claim 1, wherein the glucocorticoid receptor antagonist is administered by transdermal application, by a nebulized suspension, or by an aerosol spray. (sumobrain.com)
  • κ-Opioid receptor agonists, trans-(±)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl] cyclohexyl) benzeneacetamide methanesulfonate (U-50,488H) and dynorphin A-(1-13), improve impairments of learning and memory in mice and rats. (fujita-hu.ac.jp)
  • Furthermore, the ameliorating effects of U-50,488H and (+)-SKF10,047 were not antagonized by a selective σ receptor antagonist, N,N-dipropyl-2-[4-methoxy-3-(2-phenylenoxy)-phenyl]-ethylamine monohydrochloride (NE-100), and a selective κ-opioid receptor antagonist, nor-binaltorphimine, respectively. (fujita-hu.ac.jp)
  • 0.05 ) early (2-hour) mortality by 22% and 19% respectively. (nih.gov)
  • 0.05 vs. 2 w+U50. (nih.gov)
  • 2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. (umassmed.edu)
  • In organic chemistry, Diazines are a class of organic compounds in the organoheterocyclic compound superclass , containing a five-member heterocyclic compound with five nitrogen atoms, and two nitrogen atoms at positions 1 and 2 ( pyridazines ), 1 and 3 ( pyrimidines ), or 1 and 4 (pyrazines). (wellnessadvocate.com)
  • Among the most frequently encountered compounds in postmortem casework have been furanyl fentanyl (N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylfuran-2-carboxamide, Fu-F) and U-47700 (trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide). (unboundmedicine.com)
  • The effects of δ- and κ-receptor stimulation were antagonized by naloxone and (-)-N-(3-furylmethyl)-α-normetazocine methanesulfonate, respectively. (elsevier.com)
  • Chronic hypoxia-induced HPH was simulated by exposing the rats to 10% oxygen for 2 wk. (nih.gov)
  • 11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain. (naver.com)
  • 4. The method of claim 3, wherein the patient suffers from type 1 myotonic dystrophy. (sumobrain.com)
  • This graph shows the total number of publications written about "3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer" by people in Harvard Catalyst Profiles by year, and whether "3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer" was a major or minor topic of these publication. (harvard.edu)
  • Here we show for the first time that anxiolytic parameters of explorative behavior in mice lacking prodynorphin were increased 2-4-fold in the open field, the elevated plus maze and the light-dark test. (nih.gov)
  • Intraperitoneal injection of the KOR-specific agonist U-50488H did not affect the behavior of mice 30 min after treatment but reversed the anxiolytic phenotype of dyn (−/−) mice after 2 days (b). (nih.gov)
  • A member of this group is 2-oxo pyrrolidine, which is an intermediate in the manufacture of polyvinylpyrrolidone. (uchicago.edu)
  • Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial. (ucdenver.edu)
  • A randomized phase 2 network trial of tivantinib plus cetuximab versus cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma. (uchicago.edu)
  • Unilateral labyrinthectomy downregulates glutamate receptor delta-2 expression in the rat vestibulocerebellum. (naver.com)
  • σ Receptor agonists, (+)-N-allylnormetazocine ((+)-SKF10,047) and 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine dihydrochloride (SA4503), also reverse learning and memory impairment in various animal models. (fujita-hu.ac.jp)
  • 1 School of Nursing, University of California, San Francisco 94143. (nih.gov)