Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Aldehydes: Organic compounds containing a carbonyl group in the form -CHO.AcroleinStereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)ButanonesPentanones: 5-carbon straight-chain or branched-chain ketones.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Cycloparaffins: Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)KetonesQuinolizidines: Saturated quinolizines that are two fused six-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to CADAVERINE. Many of them are naturally occurring ALKALOIDS.Developmental Biology: The field of biology which deals with the process of the growth and differentiation of an organism.Lycopodium: A plant genus of the family LYCOPODIACEAE. Members contain ALKALOIDS. Lycopodium oil is obtained from L. clavatum.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Cinnamomum zeylanicum: The tree which is known for its bark which is sold as cinnamon. The oil contains about 65-80% cinnamaldehyde and 10% EUGENOL and many TERPENES.Nitro Compounds: Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.Anatomy, Regional: The anatomical study of specific regions or parts of organisms, emphasizing the relationship between the various structures (e.g. muscles, nerves, skeletal, cardiovascular, etc.).Awards and PrizesChalcones: Compounds based on CHALCONE. They are important intermediates in the formation of FLAVONOIDS.AcrylatesHistory, 21st Century: Time period from 2001 through 2100 of the common era.Trimethylsilyl Compounds: Organic silicon derivatives used to characterize hydroxysteroids, nucleosides, and related compounds. Trimethylsilyl esters of amino acids are used in peptide synthesis.Secosteroids: Steroids in which fission of one or more ring structures and concomitant addition of a hydrogen atom at each terminal group has occurred.Lithium Compounds: Inorganic compounds that contain lithium as an integral part of the molecule.Schiff Bases: Condensation products of aromatic amines and aldehydes forming azomethines substituted on the N atom, containing the general formula R-N:CHR. (From Grant & Hackh's Chemical Dictionary, 5th ed)Thiocholine: A mercaptocholine used as a reagent for the determination of CHOLINESTERASES. It also serves as a highly selective nerve stain.History, 20th Century: Time period from 1901 through 2000 of the common era.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Cinchona Alkaloids: Alkaloids extracted from various species of Cinchona.EstersSulfhydryl Compounds: Compounds containing the -SH radical.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.NAD(P)H Dehydrogenase (Quinone): A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.Lipid Peroxidation: Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Kinetics: The rate dynamics in chemical or physical systems.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Cell Line, Tumor: A cell line derived from cultured tumor cells.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
  • In a ceremony at FBI Headquarters on April 28, 2017, Director James B. Comey recognized the recipients of the 2016 Director's Community Leadership Award. (fbi.gov)
  • McClatchy reported in April 2018 that Mueller had obtained evidence Cohen traveled to Prague from Germany in late August or early September of 2016, but it could not be learned how that information was gleaned. (mcclatchydc.com)
  • Robert Reinders was elected director by the CPA membership for the term of July 1, 2016 to June 30, 2018. (dairyfoods.com)
  • NOTE: All the numbers on this page are for the 2011 - 2016 Senate election cycle and based on Federal Election Commission data available electronically on January 09, 2018. (opensecrets.org)
  • We used population-based mortality data from 1999 through 2016 to compare 2 underlying cause-of-death categories: diseases of heart ( International Classification of Diseases, 10th Revision [ICD-codes I00-I09, I11, I13, and I20-I51) and malignant neoplasms (ICD-10 codes C00-C97). (cdc.gov)
  • Michael then worked with the Australian Herbicide Resistance Initiative from 1999 to 2016 where he focused on the research and development of harvest weed seed control (HWSC) systems. (edu.au)
  • In 2016, progressive activist and filmmaker Michael Moore predicted that Donald Trump would defeat Hillary Clinton and pull off an upset in some Rust Belt states that ordinarily go Democratic - including Pennsylvania, Michigan and Wisconsin. (rawstory.com)
  • During the 2016 election, Moore predicted on his website, "Donald J. Trump is going to win in November. (rawstory.com)
  • Special counsel Robert Mueller's report into the Kremlin's interference in the 2016 presidential election did not find that the Trump campaign or anyone associated with it conspired or coordinated with Russia, according to a letter to Congress from Attorney General William Barr. (go.com)
  • Former Trump national security adviser Michael Flynn pleaded guilty to lying to the FBI about conversations with Russia's ambassador and disclosed that he is cooperating with the special counsel's office. (cnn.com)
  • Economic 'Recovery' Feels Weak Because the Great Recession Hasn't Really Ended, The Real News Network, October 7, 2016. (michael-hudson.com)
  • Receive email alerts on new books, offers and news in INS 2016 Mid-Year Meeting. (cambridge.org)
  • French composer and conductor Pierre Boulez (March 26, 1925-January 5, 2016) had a reputation as a hardcore modernist steeped in the dissonances of 20th-Century music, forging a career as a leading figure in contemporary classical composition. (cbsnews.com)
  • In particular, consider Coach ( NYSE:TPR ) , shares of which have been cut in half over the past three years as the iconic company struggled to fend off trendier, faster-growing competitors like Michael Kors . (fool.com)
  • Michal, adulterated and michael vick rating madden 2016 indistinguishable, returns to immolate himself with his immortal or undulant loose. (biyadi.tk)
  • A mobile phone traced to President Donald Trump's former lawyer and "fixer" Michael Cohen briefly sent signals ricocheting off cell towers in the Prague area in late summer 2016, at the height of the presidential campaign, leaving an electronic record to support claims that Cohen met secretly there with Russian officials, four people with knowledge of the matter say. (mcclatchydc.com)
  • Trump's base is every bit as excited now as it was in 2016. (rawstory.com)
  • Planning committee members, Dr. Mitchel Rosen and Dr. Michael Gochfeld have no relevant financial relationships. (rutgers.edu)
  • In light of this, we asked seven of our top contributors to offer their best ideas on where to invest money in 2016. (fool.com)
  • NEW YORK, LONDON AND TUCSON -- The Michael J. Fox Foundation for Parkinson's Research (MJFF), with Parkinson's UK and the Critical Path Institute (C-Path) in Tucson, Arizona, announce that MJFF has joined the Critical Path for Parkinson's Consortium (CPP). (michaeljfox.org)
  • Professor Michael Barton OAM is Foundation Professor of Radiation Oncology at UNSW, and Research Director of the Collaboration for Cancer Outcomes Research and Evaluation (CCORE) and the Ingham Institute for Applied Medical Research at Liverpool Hospital, as well as the Director of Research for South West Sydney Local Health District. (researchaustralia.org)
  • In 2016, age-standardized cancer mortality exceeded that for heart disease in 19 states. (cdc.gov)
  • Cancer was the second leading cause of death nationally from 1933 through 2016, except in 1936 and 1937 (1,2). (cdc.gov)
  • On Saturday night, Michael J. Fox, Julianna Margulies, Katie Couric, George Stephanopoulos and others gathered at the Waldorf-Astoria for the Michael J. Fox Foundation's annual Funny Thing Happened on The Way to Cure Parkinson's gala. (hollywoodreporter.com)
  • Fox also reflected on the 2016 deaths of Muhammad Ali and Janet Reno, both of whom dealt with Parkinson's disease in the public eye. (hollywoodreporter.com)
  • NEW YORK, GRAND RAPIDS and LONDON, UNITED KINGDOM -- The Michael J. Fox Foundation for Parkinson's Research (MJFF), Van Andel Research Institute (VARI) and The Cure Parkinson's Trust (CPT) today announced plans to collaborate on the clinical development of nilotinib, a chronic myelogenous leukemia drug that has shown potential in preliminary studies as a treatment for Parkinson's disease. (michaeljfox.org)
  • British actor Michael Caine weighs in on the Oscars diversity row which was sparked after no black stars were nominated in the main acting categories for the 2016 Academy Awards. (contactmusic.com)
  • I wouldn't expect Michael Moore to focus there, since his films delight in blistering attacks on capitalism, the U.S. healthcare system and gun culture. (juancole.com)
  • That's the metaphor that holds the film together: Since the United States has done so poorly at delivering quality of life recently (or even at winning wars) by relying on militarism, why not send Michael Moore to "invade" other countries to learn about their best practices? (juancole.com)
  • Guitarist John Berry (1963-May 19, 2016) met fellow musician Michael Diamond at the Walden School in Manhattan, and helped found the punk band Beastie Boys in 1981, along with Adam Yauch and Kate Schellenbach. (cbsnews.com)
  • A Methodist, actor William Christopher (October 20, 1932-December 31, 2016) was best known for playing the kindly and gentle Catholic priest Father Francis Mulcahy, maneuvering amid the secular goings-on of his fellow service members near the Korean War front, on the TV series "MASH. (cbsnews.com)
  • However, it will probably appeal most to readers who have neither the time nor the background to keep up with the many articles that Michael Tomasello publishes every year, but who want to find out what all the hubbub is about. (georgetown.edu)
  • I suppose that saying 2016 was an eventful year would be The Understatement of 2016! (issuu.com)
  • As we mourn those who were lost in 2016, we note the many creative talents in the music world who left us this year, and remember their singular gifts. (cbsnews.com)
  • Of those men and women in blue who died in 2016, 62 were killed by gunfire - a marked rise from the 39 the year before - about a dozen of them shot by gunmen who set out to kill police. (foxnews.com)
  • This year the agency did not announce 2016 performance year results. (thehealthcareblog.com)
  • Like performance year one (2013), two (2014), and three (2015), performance year four (2016) once again produced limited positive results. (thehealthcareblog.com)
  • In 2016 there were 432 ACOs that had their performance year results reconciled. (thehealthcareblog.com)
  • Year-over-year, or 2015 compared to 2016, quality performance improved on 27 of the 34 ACO quality measures. (thehealthcareblog.com)
  • This score is inflated since first year ACOs, or 98 ACOs in 2016, received a 1.0 score because first year participation is simply pay for reporting. (thehealthcareblog.com)
  • 2016 is already shaping up to be an extremely volatile year for the stock market, and investors know when the market threatens to fall, defensive-minded companies can be the best investments. (fool.com)
  • Today, he is struggling to feed his family as a forklift operator, a situation he says will not get better after Gov. Mike Pence refused his request for pardon. (csmonitor.com)
  • Is Mike Pence positioning himself for 2020? (csmonitor.com)
  • Singer, songwriter and actor David Bowie (January 8, 1947-January 10, 2016) frequently changed personas and musical styles, from his early rock ballads to the glam-rock of Ziggy Stardust, to the "electric soul" pop artist of "Let's Dance" and "Young Americans," and the techno-rock of "Heroes" - steadfastly refusing to be pinned down or pigeonholed. (cbsnews.com)
  • Veteran actor Michael Caine is finding it hard to step away from the spotlight. (contactmusic.com)
  • Veteran actor Sir Michael Caine 's wild drinking days of the 1960s are well behind him. (contactmusic.com)
  • Veteran actor Sir Michael Caine is spending his 81st birthday on Friday (14Mar14) gardening. (contactmusic.com)
  • British actor Sir Michael Caine on his military service. (contactmusic.com)
  • More recently, Michael completed a CSO funded doctoral fellowship (2011-2014) looking at the influence of socioeconomic factors in how problems with smoking, drinking and mental health develop over the transition to adulthood, and is now working as a Research Associate on the Measurement and Analysis of Socio-economic Inequalities in Health programme at the MRC/CSO Social & Public Health Sciences Unit. (gla.ac.uk)
  • RIO DE JANEIRO -- They are the purple circles that set social media on fire Sunday night, the circular bruises on Michael Phelps' right shoulder that left television viewers around the world wondering if the most decorated Olympian of all-time had contracted some rare skin disease, been attacked by an octopus, or perhaps was part-Dalmatian. (espn.com)
  • So, what are those circles on Michael Phelps' body? (espn.com)
  • Heart disease was the leading cause of death nationally from 1910 through 2016, except from 1918 through 1920 (1,2). (cdc.gov)
  • Although heart disease was the leading cause of death nationally as of 2016 (2-4), it is not so in many US states. (cdc.gov)