20 hydroxysteroid dehydrogenases. Medical search

Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.

Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.

A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-.

A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53).

A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.

An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.

Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.

Enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of NAD+ or NADP+ to yield estrone and NADH or NADPH. The 17-hydroxyl group can be in the alpha- or beta-configuration. EC 1.1.1.62

Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids. EC 2.8.2.

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).

A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.

A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

The rate dynamics in chemical or physical systems.

A metabolite of TESTOSTERONE or ANDROSTENEDIONE with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.

Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.

An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha-hydroxysteroids, such as from PROGESTERONE to 20-ALPHA-DIHYDROPROGESTERONE.

An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.

An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.

An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.

3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.

A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsulfate as sulfate donor to yield an aryl sulfate and adenosine 3',5'-bisphosphate. A number of aromatic compounds can act as acceptors; however, organic hydroxylamines are not substrates. Sulfate conjugation by this enzyme is a major pathway for the biotransformation of phenolic and catechol drugs as well as neurotransmitters. EC 2.8.2.1.

Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.

A flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield dihydrolipoamide and NAD+. The enzyme is a component of several MULTIENZYME COMPLEXES.

Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)

Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2.; and 1.1.99.

A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.

An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of NAD. It also acts on D-glucitol to form D-fructose. It also acts on other closely related sugar alcohols to form the corresponding sugar. EC 1.1.1.14

A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

A glucose dehydrogenase that catalyzes the oxidation of beta-D-glucose to form D-glucono-1,5-lactone, using NAD as well as NADP as a coenzyme.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Oxidoreductases that are specific for ALDEHYDES.

D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and reduced acceptor. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.47; EC 1.1.1.118; EC 1.1.1.119 and EC 1.1.99.10.

An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.

Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS.

A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.

An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Alcohol oxidoreductases with substrate specificity for LACTIC ACID.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.

Flavoproteins that catalyze reversibly the reduction of carbon dioxide to formate. Many compounds can act as acceptors, but the only physiologically active acceptor is NAD. The enzymes are active in the fermentation of sugars and other compounds to carbon dioxide and are the key enzymes in obtaining energy when bacteria are grown on formate as the main carbon source. They have been purified from bovine blood. EC 1.2.1.2.

A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. It forms a complex with ELECTRON TRANSFERRING FLAVOPROTEINS and conveys reducing equivalents to UBIQUINONE.

An enzyme that catalyzes the oxidation of XANTHINE in the presence of NAD+ to form URIC ACID and NADH. It acts also on a variety of other purines and aldehydes.

A ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO2. The enzyme requires THIAMINE DIPHOSPHATE as a cofactor. Defects in genes that code for subunits of the enzyme are a cause of MAPLE SYRUP URINE DISEASE. The enzyme was formerly classified as EC 1.2.4.3.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The E1 component of the multienzyme PYRUVATE DEHYDROGENASE COMPLEX. It is composed of 2 alpha subunits (pyruvate dehydrogenase E1 alpha subunit) and 2 beta subunits (pyruvate dehydrogenase E1 beta subunit).

Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis.

Oxidoreductases that are specific for KETONES.

The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)

Inorganic salts of sulfuric acid.

An oxidoreductase involved in pyrimidine base degradation. It catalyzes the catabolism of THYMINE; URACIL and the chemotherapeutic drug, 5-FLUOROURACIL.

An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC 1.1.1.22.

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.

Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile. (1/103)

In rat ovary, 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), a member of the aldo-keto reductase (AKR) superfamily, converts progesterone into the inactive progestin 20alpha-hydroxyprogesterone and has been implicated in the termination of pregnancy. Here we report a convenient overexpression system that permits the purification of milligram quantities of homogeneous recombinant 20alpha-HSD with wild-type enzyme activity. The availability of this enzyme has permitted detailed kinetic, inhibition and fluorescence analyses. The enzyme exhibited narrow steroid specificity, catalysing reactions only at C-20; it reduced progesterone and 17alpha-hydroxyprogesterone and oxidized 20alpha-hydroxypregnanes. It also turned over common AKR substrates, such as 9, 10-phenanthrenequinone and 4-nitrobenzaldehyde. The intrinsic fluorescence spectrum of 20alpha-HSD was characterized and was quenched on the binding of NADP(H), yielding a KNADPd of 0.36 microM and a KNADPHd of 0.64 microM. NADP(H) binding generated an energy transfer band that could not be quenched by steroids. Inhibition studies conducted with non-steroidal and steroidal anti-inflammatory drugs and synthetic oestrogens indicated that even though rat ovarian 20alpha-HSD and rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) share more than 67% amino acid identity, their inhibition profiles are markedly different. Unlike 3alpha-HSD, most of these compounds did not inhibit 20alpha-HSD. Only meclofenamic acid and hexoestrol were potent competitive inhibitors for 20alpha-HSD, yielding K(i) values of 18.9 and 14.3 microM respectively. These studies suggest that selective non-steroidal AKR inhibitors could be developed for 20alpha-HSD that might be useful in maintaining pregnancy and that specific inhibitors might be developed from either N-phenylanthranilates or biphenols. (+info)

26-cholesterol hydroxylase in rat corpora lutea: A negative regulator of progesterone secretion. (2/103)

From a subtracted cDNA library of rat luteal tissue, where cDNA fragments in functional luteal tissue were subtracted from those in regressing luteal tissue, a cDNA clone corresponding to 26-cholesterol hydroxylase (P450(C26)) was obtained. It is known that P450(C26) catalyzes the conversion of cholesterol to 26-hydroxycholesterol, which blocks cholesterol utilization in the cell, and that 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catalyzes the conversion of progesterone to an inactive steroid, 20alpha-dihydroprogesterone (20alpha-OHP). Thus, using pseudopregnant rats as a model, physiological cooperation of P450(C26) and 20alpha-HSD in the reduction of progesterone release toward the end of the luteal phase was evaluated. Levels of P450(C26) and 20alpha-HSD mRNA were examined in corpora lutea from pseudopregnant rats by Northern blot or reverse transcription-polymerase chain reaction or both. P450(C26) mRNA was ubiquitously expressed in corpora lutea, and its expression increased toward the end of pseudopregnancy, while 20alpha-HSD was expressed in all corpora lutea on Day 16 (Day 0 = the day of after cervical stimulation) but not detected before Day 10. An inhibitor of 20alpha-HSD, STZ26 (D-homo-16-oxa-4-androstene-3,16alpha-dione), was administered at various doses to rats from Day 12 to 20, effectively suppressing the elevation of 20alpha-OHP in a dose-dependent manner but not the depletion of progesterone completely. The expression of P450(C26) mRNA was increased as STZ26 dose increased, which negatively correlated with the progesterone levels. These results strongly suggest that P450(C26) cooperated with 20alpha-HSD in the reduction of progesterone release from the rat luteal tissue at the end of the functional luteal phase. (+info)

Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins. (3/103)

Hydroxysteroid dehydrogenases (HSDs) regulate the occupancy and activation of steroid hormone receptors by converting potent steroid hormones into their cognate inactive metabolites. 3alpha-HSD catalyzes the inactivation of androgens in the prostate by converting 5alpha-dihydrotestosterone to 3alpha-androstanediol, where excess 5alpha-dihydrotestosterone is implicated in prostate disease. By contrast, 20alpha-HSD catalyzes the inactivation of progestins in the ovary and placenta by converting progesterone to 20alpha-hydroxyprogesterone, where progesterone is essential for maintaining pregnancy. Mammalian 3alpha-HSDs and 20alpha-HSDs belong to the aldo-keto reductase superfamily and share 67% amino acid sequence identity yet show positional and stereospecificity for the formation of secondary alcohols on opposite ends of steroid hormone substrates. The crystal structure of 3alpha-HSD indicates that the mature steroid binding pocket consists of 10 residues located on five loops, including loop A and the mobile loops B and C. 3alpha-HSD was converted to 20alpha-HSD by replacing these loops with those found in 20alpha-HSD. However, when pocket residues in 3alpha-HSD were mutated to those found in 20alpha-HSD altered specificity was not achieved. Replacement of loop A created a 17beta-HSD activity that was absent in either 3alpha- or 20alpha-HSD. Once loops A and C were replaced, the chimera had both 3alpha- and 20alpha-HSD activity. When loops A, B, and C were substituted, 3alpha-HSD was converted to a stereospecific 20alpha-HSD with a resultant shift in k(cat)/K(m) for the desired reaction of 2 x 10(11). This study represents an example where sex hormone specificity can be changed at the enzyme level. (+info)

Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. (4/103)

Prostaglandin F(2)alpha (PGF(2)alpha) binding to its receptor on the rat corpus luteum triggers various signal transduction pathways that lead to the activation of a steroidogenic enzyme, 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which in turn catabolizes progesterone. The molecular mechanism underlying PGF(2)alpha-induced 20alpha-HSD enzyme activity has not yet been explored. In this report we show, using mice lacking PGF(2)alpha receptor and pregnant rats, that PGF(2)alpha is responsible for the rapid and massive expression of the 20alpha-HSD gene at the end of pregnancy leading to a decrease in progesterone secretion. We also present evidence that PGF(2)alpha enhances 20alpha-HSD promoter activity. We have determined a region upstream of the -1590 position in the 20alpha-HSD promoter that confers regulation by PGF(2)alpha in ovarian primary cells. This region encompasses a unique transcription factor-binding site with a sequence of a NUR77 response element. Deletion of this motif or overexpression of a NUR77 dominant negative protein caused a complete loss of 20alpha-HSD promoter activation by PGF(2)alpha. NUR77 also transactivated the 20alpha-HSD promoter in transient transfection experiments in corpus luteum-derived cells (GG-CL). This induction required the NUR77-transactivating domain. We also show that PGF(2)alpha induces a very rapid expression of NUR77 that binds to a distal response element located at -1599/-1606 but does not interact with another proximal putative NUR77 response element located downstream in the promoter. A rapid increase in NUR77 mRNA was observed in mice corpora lutea just before parturition at a time when 20alpha-HSD becomes expressed. This increase in the expression of both genes was not seen in PGF(2)alpha receptor knockout mice. By using cyclosporin A and PGF(2)alpha treatment, we established that inhibition of NUR77 DNA binding in vivo prevents PGF(2)alpha induction of the 20alpha-HSD gene in the corpus luteum. Taken together, our results demonstrate, for the first time, that PGF(2)alpha induces in the corpus luteum the expression of the nuclear orphan receptor and transcription factor, NUR77, which in turn leads to the transcriptional stimulation of 20alpha-HSD, triggering the decrease in serum progesterone essential for parturition. (+info)

Characterization of a human 20alpha-hydroxysteroid dehydrogenase. (5/103)

It has been suggested that 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) is a T-cell differentiation marker in mice. In the human, this enzyme has generally been associated with types 1 and 2 17beta-HSDs, which belong to the short-chain alcohol dehydrogenase family, whereas the rat, rabbit, pig and bovine 20alpha-HSDs are members of the aldoketo reductase superfamily, which also includes the 3alpha-HSD family. In this study, we report the cloning, from a human skin cDNA library, of a cDNA that shows, after transfection into human embryonic kidney (HEK-293) cells, high 20alpha-HSD activity but negligible 3alpha- and 17beta-hydroxysteroid dehydrogenase activities. A comparison of the amino acid sequence of the human 20alpha-HSD with those of other related 20alpha- and 3alpha-HSDs indicates that the human 20alpha-HSD shares 79.9, 68.7 and 52.3% identity with rabbit, rat and bovine 20alpha-HSDs, whereas it shows 97, 84 and 65% identity with human type 3, type 1 and rat 3alpha-HSDs. In contrast, the enzyme shares only 15.2 and 15.0% identity with type 1 and type 2 human 17beta-HSDs. DNA analysis predicts a protein of 323 amino acids, with a calculated molecular weight of 36 767 Da. In intact transfected cells, the human 20alpha-HSD preferentially catalyzes the reduction of progesterone to 20alpha-hydroxyprogesterone with a K(m) value of 0.6 microM, the reverse reaction (oxidation) being negligible. In a cell cytosolic preparation, the enzyme could use both NADPH and NADH as cofactors, but NADPH, which gave 4-fold lower K(m) values, was preferred. We detected the expression of 20alpha-HSD mRNA in liver, prostate, testis, adrenal, brain, uterus and mammary-gland tissues and in human keratinocyte (HaCaT) cells. The present study clearly indicates that the genuine human 20alpha-HSD belongs to the aldoketo reductase family, like the 20alpha-HSDs from other species. (+info)

The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. (6/103)

The human aldo-keto reductase AKR1C1 (20alpha(3alpha)-hydroxysteroid dehydrogenase) is induced by electrophilic Michael acceptors and reactive oxygen species (ROS) via a presumptive antioxidant response element (Burczynski, M. E., Lin, H. K., and Penning, T. M. (1999) Cancer Res. 59, 607-614). Physiologically, AKR1C1 regulates progesterone action by converting the hormone into its inactive metabolite 20alpha-hydroxyprogesterone, and toxicologically this enzyme activates polycyclic aromatic hydrocarbon trans-dihydrodiols to redox-cycling o-quinones. However, the significance of its potent induction by Michael acceptors and oxidative stress is unknown. 4-Hydroxy-2-nonenal (HNE) and other alpha,beta-unsaturated aldehydes produced during lipid peroxidation were reduced by AKR1C1 with high catalytic efficiency. Kinetic studies revealed that AKR1C1 reduced HNE (K(m) = 34 microm, k(cat) = 8.8 min(-1)) with a k(cat)/K(m) similar to that for 20alpha-hydroxysteroids. Six other homogeneous recombinant AKRs were examined for their ability to reduce HNE. Of these, AKR1C1 possessed one of the highest specific activities and was the only isoform induced by oxidative stress and by agents that deplete glutathione (ethacrynic acid). Several hydroxysteroid dehydrogenases of the AKR1C subfamily catalyzed the reduction of HNE with higher activity than aldehyde reductase (AKR1A1). NMR spectroscopy identified the product of the NADPH-dependent reduction of HNE as 1,4-dihydroxy-2-nonene. The K(m) of recombinant AKR1C1 for nicotinamide cofactors (K(m) NADPH approximately 6 microm, K(m)(app) NADH >6 mm) suggested that it is primed for reductive metabolism of HNE. Isoform-specific reverse transcription-polymerase chain reaction showed that exposure of HepG2 cells to HNE resulted in elevated levels of AKR1C1 mRNA. Thus, HNE induces its own metabolism via AKR1C1, and this enzyme may play a hitherto unrecognized role in a response mounted to counter oxidative stress. AKRs represent alternative GSH-independent/NADPH-dependent routes for the reductive elimination of HNE. Of these, AKR1C1 provides an inducible cytosolic barrier to HNE following ROS exposure. (+info)

Characterization of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of human recombinant 11-cis-retinol dehydrogenase. (7/103)

11-cis-Retinol dehydrogenase catalyzes the oxidation of cis-retinols, a rate-limiting step in the biosynthesis of 9-cis-retinoic acid. It is also active toward 3alpha-hydroxysteroids, and thus might be involved in steroid metabolism. To better understand the role of this enzyme, we produced stable transfectants expressing 11-cis-retinol dehydrogenase in human embryonic kidney 293 cells. In vitro enzymatic assays have demonstrated that, with an appropriate exogenous cofactor, the enzyme catalyzes the interconversion of 5alpha-androstane-3alpha,17beta-diol and dihydrotestosterone and that of androsterone and androstanedione. However, using intact transfected cells, we found that the enzyme catalyzes reactions only in the oxidative direction. Thus, it is possible that 5alpha-androstane-3alpha,17beta-diol (an inactive androgen) can be converted into dihydrotestosterone, the most potent androgen, by the action of 11-cis-retinol dehydrogenase. This reaction could constitute a non-classical pathway of production of active androgens in the peripheral tissues. We also showed that all-trans-, 9-cis- and 13-cis-retinol inhibit the oxidative 3alpha-hydroxysteroid steroid activity of 11-cis-retinol dehydrogenase with similar K(i) values. Since all-trans-retinol is a precursor of cis-retinols, its inhibitory effect on the activity suggests that it could play an important role in modulating the formation of 9-cis-retinoic acid. In addition, we examined the effect of several known enzyme modulators, namely carbenoxolone, phenylarsine oxide and phosphatidylcholine, on 11-cis-retinol dehydrogenase activity. Taken together, our results suggest that, in humans, this enzyme might play a role in the biosynthesis of both 9-cis-retinoic acid and dihydrotestosterone. (+info)

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. (8/103)

The natural indoles 3,3'-diindolylmethane (DIM), ascorbigen (ASG), indole-3-carbinol (I3C), and indolo[3,2-b]carbazole (ICZ), as well as the natural isothiocyanates sulforaphane (SUL), benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC), all possess cancer chemopreventive properties. It is now shown that DIM, ICZ, SUL, and BITC can each stimulate apoptosis in human colon adenocarcinoma LS-174 and Caco-2 cells. Treatment of LS-174 cells with nontoxic doses of DIM, ASG, I3C, or ICZ affected an increase of up to 21-fold in cytochrome P450 1A1 (CYP1A1). None of these indoles caused an elevation in either aldo-keto reductase 1C1 (AKR1C1) or the gamma-glutamylcysteine synthetase heavy subunit (GCS(h)), but DIM, I3C, and ICZ produced a very modest increase in NAD(P)H:quinone oxidoreductase 1 (NQO1). By contrast, nontoxic doses of SUL, BITC, or PEITC failed to induce expression of CYP1A1 in LS-174 cells, but caused an increase of between 11- and 17-fold in the protein levels of AKR1C1, NQO1, and GCS(h). Treatment of the colon cell line with ICZ or SUL caused increases in the levels of mRNA for CYP1A1, AKR1C1, and NQO1 that were consistent with the enzyme data. Exposure of Caco-2 cells to media containing indoles or isothiocyanates gave similar results to those obtained using LS-174 cells. Evidence is presented that the ability of indoles and isothiocyanates to stimulate either xenobiotic response element- or antioxidant response element-driven gene expression accounts for the two groups of phytochemicals inducing different gene batteries. Pretreatment of LS-174 cells for 24 h with ICZ and SUL before exposure for 24 h to benzo(a)pyrene (BaP) reduced to <20% the number of single-strand DNA breaks produced by the carcinogen. Neither ICZ alone nor SUL alone were able to confer the same degree of protection against DNA damage produced by BaP as they achieved in combination. Similar results were obtained with H(2)O(2) as the genotoxic agent. Together, these phytochemicals may prevent colon tumorigenesis by both stimulating apoptosis and enhancing intracellular defenses against genotoxic agents. (+info)

Hydroxysteroid Dehydrogenase (3.BETA.-HSD), 17.ALPHA.-Hydroxylase and 17, 20 Lyase by Progestins and Danazol". Endocrinologia ... 3β-Hydroxysteroid dehydrogenase inhibitors, Tertiary alcohols, Ethynyl compounds, Androgens and anabolic steroids, ... p. 5. Archived from the original (RTF) on 2006-06-20. Retrieved 2006-06-01. Arakawa, Satoko; Mitsuma, Mizue; Iyo, Masato; ... 11-trien-20-yn-17β-ol-3-one, is a synthetic estrane steroid and a derivative of testosterone. It is more specifically a ...

https://en.wikipedia.org/wiki/Gestrinone

3α-hydroxysteroid dehydrogenase type 3, and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the ... This enzyme binds bile acid with high affinity, and shows minimal 3α-hydroxysteroid dehydrogenase activity. This gene shares ... hydroxysteroid dehydrogenase)". National Center for Biotechnology Information, U.S. National Library of Medicine. This article ... "Entrez Gene: AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)- ...

https://en.wikipedia.org/wiki/AKR1C2

CYP17A1 17-beta-hydroxysteroid dehydrogenase X deficiency; 300438; HSD17B10 2-methylbutyrylglycinuria; 610006; ACADSB 3- ... PC Pyruvate dehydrogenase deficiency; 312170; PDHA1 Pyruvate dehydrogenase E2 deficiency; 245348; DLAT Pyruvate dehydrogenase ... SCARB2 Acyl-CoA dehydrogenase, long chain, deficiency of; 201460; ACADL Acyl-CoA dehydrogenase, medium chain, deficiency of; ... DCX Succinic semialdehyde dehydrogenase deficiency; 271980; ALDH5A1 Succinyl-CoA:3-oxoacid CoA transferase deficiency; 245050; ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

Estrone can also be reversibly converted into estradiol by 17β-hydroxysteroid dehydrogenases (17β-HSDs), and this accounts for ... Poirier D (September 2010). "17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review". Expert Opin Ther Pat. 20 (9): ... "17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast ... 36 (20): 4410-5. Bibcode:2002EnST...36.4410L. doi:10.1021/es010323a. PMID 12387416. Dang Z, Ru S, Wang W, Rorije E, Hakkert B, ...

https://en.wikipedia.org/wiki/Estrone_(medication)

"Entrez Gene: HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3". "Testosterone 17-beta-dehydrogenase deficiency - Conditions - ... 17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) is an enzyme that in humans is encoded by the HSD17B3 gene and is involved in ... 17β-Hydroxysteroid dehydrogenase GRCh38: Ensembl release 89: ENSG00000130948 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Rösler A, Silverstein S, Abeliovich D (May 1996). "A (R80Q) mutation in 17 beta-hydroxysteroid dehydrogenase type 3 gene among ...

https://en.wikipedia.org/wiki/HSD17B3

... and 17β-hydroxysteroid-dehydrogenase 1 (converts estrone into estradiol) and upregulates estrone sulfotransferase. However, ... and this was administered from the fifth day through the twenty-fourth day of the menstrual cycle. [...] We observed each of 33 ... and androstenedione is converted by 17β-hydroxysteroid dehydrogenases into testosterone. CYP17A1, the cytochrome P450 gene that ... causes downregulation of the ER and upregulation of the estrogen-inactivating enzymes 17β-hydroxysteroid dehydrogenase 2 ( ...

https://en.wikipedia.org/wiki/Pharmacodynamics_of_progesterone

It is biosynthesized by 3α-hydroxysteroid dehydrogenase from progesterone. 3α-DHP has been found to act as a positive ... 3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxyprogesterone, as well as pregn-4-en-3α-ol-20-one, is an endogenous ... "Reduction of predator odor-induced anxiety in mice by the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP)". Brain ...

https://en.wikipedia.org/wiki/3α-Dihydroprogesterone

"Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase ... "Entrez Gene: HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method ... The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during ... 2006). "Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12". J. Steroid ...

https://en.wikipedia.org/wiki/HSD17B12

It is biosynthesized by 3β-hydroxysteroid dehydrogenase from progesterone. Unlike 3α-dihydroprogesterone (3α-DHP), 3β-DHP does ... In the Clauberg bioassay the 3β-hydroxy-4-pregnen-20-one shows about the same potency as progesterone (34). In regard to the ... 3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone, or pregn-4-en-3β-ol-20-one (4-pregnenolone, δ4- ... "Reduction of predator odor-induced anxiety in mice by the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP)". Brain ...

https://en.wikipedia.org/wiki/3β-Dihydroprogesterone

Roland, BL; Li, KX; Funder, JW (Oct 1995). "Hybridization histochemical localization of 11 beta-hydroxysteroid dehydrogenase ... and 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2). HSD2 is an enzyme that metabolizes cortisol and other ... Geerling, JC; Kawata, M; Loewy, AD (Jan 20, 2006). "Aldosterone-sensitive neurons in the rat central nervous system". The ...

https://en.wikipedia.org/wiki/HSD2_neuron

... has been reported to act as an inhibitor of 17β-hydroxysteroid dehydrogenases. 16-Ketoestrone can be converted ... by 16α-hydroxysteroid dehydrogenase into estriol in the body. Breuer, Heinz (1962). "The Metabolism of the Natural Estrogens". ... "Affinity labeling of arginyl residues at the catalytic region of estradiol 17 beta-dehydrogenase from human placenta by 16- ... 20: 285-335. doi:10.1016/S0083-6729(08)60720-7. ISBN 9780127098203. ISSN 0083-6729. Huffman MN, Lott MH (January 1948). "16- ...

https://en.wikipedia.org/wiki/16-Ketoestrone

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in ... dehydrogenase 2". Moeller G, Adamski J (2006). "Multifunctionality of human 17beta-hydroxysteroid dehydrogenases". Mol. Cell. ... Soubhye J, Alard IC, van Antwerpen P, Dufrasne F (2015). "Type 2 17-β hydroxysteroid dehydrogenase as a novel target for the ... Zhang Y, Word RA, Fesmire S, Carr BR, Rainey WE (Oct 1996). "Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase ...

https://en.wikipedia.org/wiki/HSD17B2

D4A is formed from abiraterone by 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD). It is said to be a more potent ... 3β-Hydroxysteroid dehydrogenase inhibitors, 5α-Reductase inhibitors, Androstanes, CYP17A1 inhibitors, Hormonal antineoplastic ... D4A is specifically an inhibitor of CYP17A1 (17α-hydroxylase/17,20-lyase), 3β-HSD, and 5α-reductase. In addition, it has also ...

https://en.wikipedia.org/wiki/Δ4-Abiraterone

Hepatic metabolism is mediated by 11 beta-hydroxysteroid dehydrogenases (11[beta]-HSD) and 20-ketosteroid reductases. ... 20 mg/day of prednisone (16 mg/day of methylprednisolone) is the threshold dosage for PAE development agreed upon by many ... Depo-Medrol is available as sterile aqueous solution in 20 mg/mL, 40 mg/mL, or 80 mg/mL strengths. Solu-Medrol is the only ... 20 August 2019. Retrieved 20 February 2020. "List of nationally authorised medicinal products : Active substance: ...

https://en.wikipedia.org/wiki/Methylprednisolone

... while 3β-hydroxysteroid dehydrogenase and hydroxysteroid sulfotransferases are involved in excitatory neurosteroid production. ... 5α-reductase type I and 3α-hydroxysteroid dehydrogenase are involved in the biosynthesis of inhibitory neurosteroids, ... alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines" (pdf). Biological & Pharmaceutical ... Usami N, Yamamoto T, Shintani S, Ishikura S, Higaki Y, Katagiri Y, Hara A (April 2002). "Substrate specificity of human 3(20) ...

https://en.wikipedia.org/wiki/Neurosteroid

In the final and rate limiting step, the C17 keto group androstenedione is reduced by 17β-hydroxysteroid dehydrogenase to yield ... In addition, the 3β-hydroxyl group is oxidized by 3β-hydroxysteroid dehydrogenase to produce androstenedione. ... 3α-hydroxysteroid dehydrogenase, and 17β-HSD, in that order. Androsterone and etiocholanolone are then glucuronidated and to a ... which regulates the expression of 17β-hydroxysteroid dehydrogenase. The amount of testosterone synthesized is regulated by the ...

https://en.wikipedia.org/wiki/Testosterone

... and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type 1". J. ... 90-. ISBN 978-0-08-054423-6. MORFIN Robert (20 December 2010). Les stéroïdes naturels de A à Z. Lavoisier. pp. 427-. ISBN 978-2 ...

https://en.wikipedia.org/wiki/7α-Hydroxyepiandrosterone

3β-Hydroxysteroid dehydrogenases represent another enzyme class that is predicted to be involved in cardenolide biosynthesis. ... Expression of two progesterone 5β-reductase and three 3β-hydroxysteroid dehydrogenase genes was detected in shoot cultures. ... Comparison to A. thaliana genes identified three predicted 3β-hydroxysteroid dehydrogenases in E. crepidifolium (EcHSD1, EcHSD2 ... "Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and ...

https://en.wikipedia.org/wiki/Erysimum_crepidifolium

The critical enzyme step is two-fold using a 3β-hydroxysteroid dehydrogenase and a Δ5-4 isomerase. The latter transfers the ... 3β-Dihydroprogesterone (pregn-4-en-3β-ol-20-one) is an isomer of pregnenolone in which the C5 double bond has been replaced ... Pregnenolone is also known chemically as pregn-5-en-3β-ol-20-one. Like other steroids, it consists of four interconnected ... Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the ...

https://en.wikipedia.org/wiki/Pregnenolone

... blocks production of all steroid hormones from cholesterol 3β-Hydroxysteroid dehydrogenase 2 deficiency: impairs progestogen ... XX Patient With R550W Mutation in POR: Expanding the PORD Phenotype". The Journal of Clinical Endocrinology & Metabolism. 105 ( ... additionally results in elevated methemoglobin and/or methemoglobinemia 17β-Hydroxysteroid dehydrogenase 3 deficiency: impairs ... Cytochrome b5 deficiency: subtype of isolated 17,20-lyase deficiency; ...

https://en.wikipedia.org/wiki/Inborn_errors_of_steroid_metabolism

2005). "A novel somatic mutation of the 3beta-hydroxysteroid dehydrogenase gene in sporadic cutaneous verruciform xanthoma". ... encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome". Am J Med Genet. 90 (4): 339-46. doi:10.1002/(SICI)1096- ... "Entrez Gene: NSDHL NAD(P) dependent steroid dehydrogenase-like". Konig A, Happle R, Bornholdt D, Engel H, Grzeschik KH (Apr ... Ohashi M, Mizushima N, Kabeya Y, Yoshimori T (Sep 2003). "Localization of mammalian NAD(P)H steroid dehydrogenase-like protein ...

https://en.wikipedia.org/wiki/NSDHL

This is followed by the further reduction of these metabolites via 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid ... This reaction is catalyzed by 3β-hydroxysteroid dehydrogenase/δ5-4-isomerase. Progesterone in turn is the precursor of the ... Progesterone is highly susceptible to enzymatic reduction via reductases and hydroxysteroid dehydrogenases due to its double ... 11β-Hydroxysteroid dehydrogenase inhibitors, Alkene derivatives, Antimineralocorticoids, Diketones, GABAA receptor positive ...

https://en.wikipedia.org/wiki/Progesterone

... a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721-7. doi:10.1210/jcem. ... 20 (3): 397-403. doi:10.1006/geno.1994.1193. PMID 8034312. "Entrez Gene: RXRG retinoid X receptor, gamma". Li D, Wang F, ... 20 (45): 6638-42. doi:10.1038/sj.onc.1204695. PMID 11641790. S2CID 7377737. Brabender J, Danenberg KD, Metzger R, Schneider PM ...

https://en.wikipedia.org/wiki/Retinoid_X_receptor_gamma

2004). "Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on ... "Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and ... 274 (20): 14122-9. doi:10.1074/jbc.274.20.14122. PMID 10318829. Trickett JI, Patel DD, Knight BL, et al. (2001). " ...

https://en.wikipedia.org/wiki/AADAC

... and 3β-hydroxysteroid dehydrogenases in the skin. On the other hand, other research has cast doubt on the notion that ... after further transformation by 3α-hydroxysteroid dehydrogenase) are allopregnanolone and pregnanolone, respectively. With oral ... A 20- or 21-gauge needle has been reported to be suitable for the injection of aqueous suspensions of microcrystalline ... The microspheres range in size from 33 to 75 μg and are delivered using pre-filled syringes with a 20-gauge 38 mm needle. Peak ...

https://en.wikipedia.org/wiki/Pharmacokinetics_of_progesterone

Unlike CPA, cyproterone seems to show some inhibition of 17β-hydroxysteroid dehydrogenase and 5α-reductase in vitro. In ... Cyproterone seemed to decrease the activity of 17α-hydroxysteroid dehydrogenase and of 5α-steroid reductase in human prostate ... Cyproterone (6-chloro-17-hydroxy-1,2α-methylenepregna-4,6-diene-3,20-dione) and cyproterone acetate (17-acetoxy-6-chloro-1,2α- ... Cyproterone (6-chloro-17a-hydroxy-1a,2a-methylene-pregna-4,6-diene-3,20-dione) and cyproterone acetate have received ...

https://en.wikipedia.org/wiki/Cyproterone

Casey ML, MacDonald PC, Andersson S (November 1994). "17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and ... and AKR1C3 and the 17β-hydroxysteroid dehydrogenase (17β-HSD) HSD17B1. 20α-DHP can be transformed back into progesterone by 20α ... In animal studies, 20α-DHP has been found to be selectively taken up into and retained in target tissues such as the uterus, ... 20α-DHP is formed from progesterone in the liver and in target tissues such as the endometrium. It appears to be more slowly ...

https://en.wikipedia.org/wiki/20α-Dihydroprogesterone

3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene. ... Khanna M, Qin KN, Cheng KC (Jun 1995). "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning ... Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R (Aug 2003). "Human 20alpha-hydroxysteroid dehydrogenase: ... Zhang Y, Dufort I, Rheault P, Luu-The V (Oct 2000). "Characterization of a human 20alpha-hydroxysteroid dehydrogenase". Journal ...

https://en.wikipedia.org/wiki/AKR1C1

... cytokine was originally discovered via the observation that it induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in ... Ihle JN, Pepersack L, Rebar L (June 1981). "Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid ... dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J. Immunol. 126 (6): 2184-9. PMID 6971890. Ihle ...

https://en.wikipedia.org/wiki/Interleukin_3

Raimondi SG, Olivier NS, Patrito LC, Flury A (1989). "Regulation of the 3 beta-hydroxysteroid dehydrogenase activity in tissue ... 32 (3): 413-20. doi:10.1016/0022-4731(89)90215-X. PMID 2523011. Sippell WG, Dörr HG, Bidlingmaier F, Knorr D (1980). "Plasma ...

https://en.wikipedia.org/wiki/List_of_steroid_abbreviations

Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause ... 多囊性卵巢綜合症是18歲到44歲女性間最常見的內分泌疾病[15]。一般認為，多囊卵巢綜合症的發生率在女性生育年齡期間佔約20%（根據鹿特丹診斷指引，英國為26%、澳洲為17.8%、土耳其為19.9%、伊朗為15.2%[16]。）多囊卵巢綜合症是現今導致不 ... 2014, 20 (5): 656-69. PMID 24861556. doi:10.1093/humupd/dmu022

https://zh.wikipedia.org/wiki/多囊卵巢綜合症

testicular: enzymatic (5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency) · Androgen receptor ( ... Maelezo ya mgonjwa Archived 20 Novemba 2008 at the Wayback Machine. (PDF) ...

https://sw.wikipedia.org/wiki/Ugonjwa_wa_Cushing

... is formed from bupropion via reduction of the ketone group by 11β-hydroxysteroid dehydrogenase-1 and aldo- ... In any case, it is about 20% as pharmacologically potent as bupropion and in the range of 20 to 50% as potent as bupropion in ...

https://en.wikipedia.org/wiki/Threohydrobupropion

... adrenal hyperplasia due to 21-hydroxylase deficiency Congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase ... trisomy 2q37 Chromosome 20 - Chromosome 22 Chromosome 20 ring Chromosome 20, deletion 20p Chromosome 20, duplication 20p ... Chromosome 20, trisomy Chromosome 21 monosomy Chromosome 21 ring Chromosome 21, monosomy 21q22 Chromosome 21, tetrasomy 21q ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

... factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase ... 272 (20): 12928-37. doi:10.1074/jbc.272.20.12928. PMID 9148898. "Entrez Gene: TEAD3 TEA domain family member 3". Bürglin, TR ( ...

https://en.wikipedia.org/wiki/TEAD3

"The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization". J. Biol ... Dehydrogenase/reductase (SDR family) member 7B is an enzyme encoded by the DHRS7B gene in humans, found on chromosome 17p11.2. ... "Entrez Gene: Dehydrogenase/reductase (SDR family) member 7B". "Genecards: DHRS7B Gene protein-coding GIFtS 47". Tannin GM, ... DHRS7B is a member of the short chain dehydrogenase/reductase (SDR) superfamily and possesses characteristic features of an SDR ...

https://en.wikipedia.org/wiki/DHRS7B

... estrone is also formed reversibly from estradiol by the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD) in various tissues, ... doi:10.1016/S0021-9258(20)82036-5. PMID 6863280. Lundström E, Conner P, Naessén S, Löfgren L, Carlström K, Söderqvist G (2015 ...

https://en.wikipedia.org/wiki/Estrone

Additionally, there is an abundance of 11β-hydroxysteroid dehydrogenase 1 expressed in the foetal membranes. This enzyme ... 20-26. doi:10.1007/978-1-349-02807-8_2. ISBN 9781349028092. Baergen RN (2005). Manual of Benirschke and Kaufmann's Pathology of ... 20 July 2016. Retrieved 16 June 2022. Johnson MH (2018-01-12). Essential reproduction (Eighth ed.). Hoboken, NJ. ISBN ...

https://en.wikipedia.org/wiki/Fetal_membranes

... hydroxysteroid dehydrogenase type 3 enzyme deficiencies). The measurement of the serum DHT concentration is challenging since ... XY DSD from other causes such as partial androgen insensitivity syndrome and 17β-hydroxysteroid dehydrogenase 3 deficiency. ... XY persons with 5alpha-reductase-2 deficiency and 17beta-hydroxysteroid dehydrogenase-3 deficiency". Archives of Sexual ... 20 September 2015. Fausto-Sterling, Anne (2000). Sexing the Body: Gender politics and the construction of sexuality (1st ed.). ...

https://en.wikipedia.org/wiki/5α-Reductase_2_deficiency

... placental 11β-hydroxysteroid dehydrogenase type 2, and infant HPA axis development in humans: Psychosocial and physiological ... stress and trauma during pregnancy has been shown to reduce the expression of placental enzyme 11B-hydroxysteroid dehydrogenase ... Retrieved 20 May 2020. Dalgaard, Nina Thorup; Thøgersen, Marie Høgh; Riber, Karin (2020-08-06), De Haene, Lucia; Rousseau, ... 20 (11): 1123-32. doi:10.1016/0145-2134(96)00102-0. PMID 8958463. Bretherton I (1990). "Communication patterns, internal ...

https://en.wikipedia.org/wiki/Transgenerational_trauma

Stalvey JR (July 2002). "Inhibition of 3beta-hydroxysteroid dehydrogenase-isomerase in mouse adrenal cells: a direct effect of ... 20 (4): 365-374. doi:10.1055/s-2002-36709. ISSN 1526-8004. PMID 12536359. Gil M, Oliva B, Timoner J, Maciá MA, Bryant V, de ... 1.1% at 12 months). CPA at relatively low doses, for instance 10-20 mg/day, has been reported in small studies to cause few to ... 46 (6): 1015-20. doi:10.1016/S0015-0282(16)49873-0. PMID 2946604. Diamanti-Kandarakis E (October 1998). "How actual is the ...

https://en.wikipedia.org/wiki/Side_effects_of_cyproterone_acetate

... does not inhibit 5α-reductase, aromatase, or 3α- or 3β-hydroxysteroid dehydrogenase in vitro. The drug significantly ... Zanoterone (INN, USAN) (former developmental code name WIN-49596), also known as (5α,17α)-1'-(methylsulfonyl)-1'-H-pregn-20-yno ...

https://en.wikipedia.org/wiki/Zanoterone

... although in physiologic doses this is prevented by rapid degradation of cortisol by 11β-hydroxysteroid dehydrogenase isoenzyme ... 90: 17-20. doi:10.3899/jrheum.120337. PMID 22942324. S2CID 31663619. Haywood A, Good P, Khan S, Leupp A, Jenkins-Marsh S, ...

https://en.wikipedia.org/wiki/Glucocorticoid

August 2003). "Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase ... 20 (5): 656-669. doi:10.1093/humupd/dmu022. PMID 24861556. Wang FF, Wu Y, Zhu YH, Ding T, Batterham RL, Qu F, Hardiman PJ ( ... It affects approximately 2% to 20% of this age group depending on how it is defined. When someone is infertile due to lack of ... Around 20% of European women have polycystic ovaries (the prevalence is even higher in some other populations) but ...

https://en.wikipedia.org/wiki/Polycystic_ovary_syndrome

Rosler A (August 2006). "17 beta-hydroxysteroid dehydrogenase 3 deficiency in the Mediterranean population". Pediatric ... glucose-6-phosphate dehydrogenase deficiency, and fragile X syndrome (FXS), which is an inherited genetic condition with ... glucose-6-phosphate dehydrogenase deficiency, alpha-thalassemia, molecular characterization, recessive osteoperosis, ... 16 (20): 2224-2231. doi:10.2174/138161210791792804. PMID 20459387. Zlotogora J, van Baal S, Patrinos GP (October 2007). " ...

https://en.wikipedia.org/wiki/Genetic_studies_on_Arabs

5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor ... 138 (3): 911-20. doi:10.1016/j.neuroscience.2005.10.016. PMID 16325348. S2CID 23576732. Eser D, Romeo E, Baghai TC, di Michele ... Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as ...

https://en.wikipedia.org/wiki/Tetrahydrodeoxycorticosterone

There is an enzyme in the placenta called 11beta-hydroxysteroid dehydrogenase type 2 that is capable of inactivating the vast ... called Placental 11 β-hydroxysteroid-dehydrogenase. The problem lies in the multiplying factor arising from this ratio, i.e., ... if maternal cortisol levels rise by 10-20% it could cause foetal cortisol levels to double, which is what occurs when the ...

https://en.wikipedia.org/wiki/Maternal_fetal_stress_transfer

... via 17β-hydroxysteroid dehydrogenase), and conjugation (via sulfation and glucuronidation). The elimination half-lives of ... 20 (4B): 1005-13. doi:10.1016/0022-4731(84)90011-6. PMID 6202959. Terenius L, Ljungkvist I (1972). "Aspects on the mode of ... 100 (11): 4012-20. doi:10.1210/jc.2015-2237. PMID 26544651. Gregory Y. H. Lip; John E. Hall (28 June 2007). Comprehensive ... 104 (20): 1815. doi:10.1001/jama.1935.92760200002012. ISSN 0098-7484. Rothenberg, Carla J. (25 April 2005). "The Rise and Fall ...

https://en.wikipedia.org/wiki/Estrogen_(medication)

Other names in common use include 3beta-hydroxysteroid 5beta-oxidoreductase, and 3beta-hydroxysteroid 5beta-progesterone ... In enzymology, a 3beta-hydroxy-5beta-steroid dehydrogenase (EC 1.1.1.277) is an enzyme that catalyzes the chemical reaction ... 20-dione + NADPH + H+ Thus, the two substrates of this enzyme are 3beta-hydroxy-5beta-pregnane-20-one and NADP+, whereas its 3 ... products are 5beta-pregnan-3,20-dione, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those ...

https://en.wikipedia.org/wiki/3beta-hydroxy-5beta-steroid_dehydrogenase

... placental 11β-hydroxysteroid dehydrogenase type 2, and infant HPA axis development in humans: Psychosocial and physiological ... Around 10-20% of women suffer from mental health concerns during the perinatal period due to their vulnerability and emotion. ... Also, stressed males had larger sexually dimorphic nucleus of the preoptic area at birth, but then at 20 and 60 days are found ... Whereas control males are two times larger than control females on days 20 and 60, but the stressed males show no statistical ...

https://en.wikipedia.org/wiki/Prenatal_stress

Ferrari P, Krozowski Z (April 2000). "Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation". ... Retrieved 2009-06-20. Palm F, Urbanek C, Grau A (April 2009). "Infection, its treatment and the risk for stroke". Current ... 20 (2): 100-6. doi:10.1111/j.1745-7599.2007.00292.x. PMID 18271765. S2CID 208287631.[dead link] Walsh JB (October 1982). " ... Retrieved 2009-06-20. Safar ME, Jankowski P (February 2009). "Central blood pressure and hypertension: role in cardiovascular ...

https://en.wikipedia.org/wiki/Complications_of_hypertension

... reductase Δ5-3β-hydroxysteroid dehydrogenase 3β-hydroxy-5-ene steroid dehydrogenase 3β-hydroxy steroid dehydrogenase/isomerase ... steroid-Δ5-3β-ol dehydrogenase 3β-HSDH 5-ene-3β-hydroxysteroid dehydrogenase 3β-hydroxy-5-ene-steroid dehydrogenase 3β-HSD is ... 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) (EC 1.1.1.145) is an enzyme that catalyzes the biosynthesis of the ... Steroidogenic enzyme 3α-Hydroxysteroid dehydrogenase Cravioto MD, Ulloa-Aguirre A, Bermudez JA, Herrera J, Lisker R, Mendez JP ...

https://en.wikipedia.org/wiki/3β-Hydroxysteroid_dehydrogenase

... hydroxysteroid dehydrogenase (HSD) deficiency is an inherited disorder that affects hormone-producing glands including the ... medlineplus.gov/genetics/condition/3-beta-hydroxysteroid-dehydrogenase-deficiency/ 3-beta-hydroxysteroid dehydrogenase ... 3-beta (β)-hydroxysteroid dehydrogenase (HSD) deficiency is an inherited disorder that affects hormone-producing glands ... Pan Y, Zhong S, Hu RM, Gong W. Mutation of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) at the 3-untranslated region is ...

https://medlineplus.gov/genetics/condition/3-beta-hydroxysteroid-dehydrogenase-deficiency

... hydroxysteroid:NAD+ oxidoreductase also known as 3\xCE\xB1(or 20\xCE\xB2)-hydroxysteroid dehydrogenase ... hydroxysteroid dehydrogenase:. *1hdc: Mechanism of Inhibition of 3alpha,20beta-hydroxysteroid Dehydrogenase by a Licorice- ... Hydroxysteroid Dehydrogenase and Possible Roles of The Residues Conserved in Short-chain Dehydrogenases ... 1n5d: Crystal Structure of Porcine Testicular Carbonyl Reductase/ 20beta-hydroxysteroid Dehydrogenase. *1nff: Crystal Structure ...

http://enzymes.me.uk/enzyme/ec_1_1_1_53

3alpha(or 20beta)-hydroxysteroid dehydrogenase / testosterone dehydrogenase (NAD+) activity / androsterone dehydrogenase ... hydroxysteroid dehydrogenase / 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity / 3alpha(17beta)-hydroxysteroid ... 17-beta-hydroxysteroid dehydrogenase type 5 / 17-beta-HSD 5 / 3-alpha-HSD type II / brain / 3-alpha-hydroxysteroid ... 17-beta-hydroxysteroid dehydrogenase (NAD+) activity / NAD-retinol dehydrogenase activity / aldo-keto reductase (NADP) activity ...

https://pdbj.org/emnavi/quick.php?id=pdb-4fam

11-beta-Hydroxysteroid Dehydrogenase Type 2 11-beta-Hydroxysteroid Dehydrogenases 11-Dehydroprostaglandin F2alpha use ... 46, XX Disorders of Sex Development 46, XX Testicular Disorders of Sex Development ... 2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase use 3-Oxo-5-alpha-Steroid 4-Dehydrogenase ...

https://decs.bvs.br/I/DeCS2011_Alfab-0a9.htm

17Beta-hydroxysteroid dehydrogenase-3 deficiency: diagnosis, phenotypic variability, population genetics, and worldwide ... The presence of a uterus and ovaries strongly suggests a virilized female (46,XX) infant. ... Individuals with 17-beta hydroxysteroid dehydrogenase deficiency most often have female-appearing genitalia and, less often, ... Phenotypic variability in 17beta-hydroxysteroid dehydrogenase-3 deficiency and diagnostic pitfalls. Clin Endocrinol (Oxf). 2007 ...

https://www.medscape.com/answers/923178-122231/what-is-the-pathophysiology-of-microphallus

3Beta-hydroxysteroid dehydrogenase type-2 (3β-HSD 2) deficiency *Congenital lipoid adrenal hyperplasia (lipoid CAH) (StAR ... 17α-hydroxylase/17, 20-lyase (P450C17) or CYP17 deficiency * ...

https://www.elsevier.com/books/congenital-adrenal-hyperplasia/hindmarsh/978-0-12-811483-4

3-β hydroxysteroid dehydrogenase/isomerase. Steroid metabolism. 17. (26). group_273. Recombinase/resolvase. Mobile genetic ... CDC twenty four seven. Saving Lives, Protecting People A-Z Index × Submit. ... NADH-dependent dehydrogenase. Putative functions. 26. NA. nmrA. Putative nmrA negative transcriptional regulator family protein ...

https://wwwnc.cdc.gov/eid/article/27/3/20-0852-t2

17β-hydroxysteroid dehydrogenase; RoDH1, retinol dehydrogenase type 1; ⬇, binding to the steroid receptor described. ... Zumoff, B.; Rosenfeld, R.S.; Strain, G.W.; Levin, J.; Fukushima, D.K. Sex differences in the twenty-four-hour mean plasma ... 17β-hydroxysteroid dehydrogenase; RoDH1, retinol dehydrogenase type 1; ⬇, binding to the steroid receptor described. ... converted from DHEA by 17β-hydroxysteroid dehydrogenase (Figure 3). Synthetic DHEA analog HE3286 increased the frequency of CD4 ...

https://www.mdpi.com/1422-0067/20/19/4660/htm

Pitfalls in hormonal diagnosis of 17-beta hydroxysteroid dehydrogenase III deficiency. Ahmed Khattab, Tony Yuen, Mabel Yau, ... Dive into the research topics of Pitfalls in hormonal diagnosis of 17-beta hydroxysteroid dehydrogenase III deficiency. ...

https://ohsu.pure.elsevier.com/en/publications/pitfalls-in-hormonal-diagnosis-of-17-beta-hydroxysteroid-dehydrog/fingerprints/

... dihydrodiol dehydrogenase 1,dihydrodiol dehydrogenase isoform DD1,hepatic dihydrodiol dehydrogenase,trans- ... High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: ... aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) ... 20 alpha-hydroxysteroid dehydrogenase,OTTHUMP00000018992,aldo-keto reductase C,aldo-keto reductase family 1, member C1, ...

https://www.abnova.com/products/products_detail.asp?catalog_id=H00001645-B01P

17-Hydroxysteroid Dehydrogenases - biosynthesis - genetics Breast Neoplasms - enzymology - genetics - metabolism - pathology ... 17beta-Hydroxysteroid dehydrogenase type 1 (17HSD1), type 2 (17HSD2), and type 5 (17HSD5) are associated with sex steroid ... 17beta-hydroxysteroid dehydrogenase type 1 is an independent prognostic marker in breast cancer. https://arctichealth.org/en/ ... 2004 Oct 15;64(20):7604-9 Date. Oct-15-2004 Language. English Publication Type. Article Keywords. ...

https://arctichealth.org/en/list?q=topic%3A%22Immunohistochemistry%22&p=1&ps=&sort=title_sort+asc

... hydroxysteroid dehydrogenase like 2, HSDL2, Hsdl2 Background Full Gene Name: hydroxysteroid dehydrogenase like 2. Synonyms: ... HSDL2 (Hydroxysteroid Dehydrogenase Like 2 (HSDL2)) Binding Specificity All epitopes for HSDL2 antibodies * AA 229-258 9 ... anti-Hydroxysteroid Dehydrogenase Like 2 (HSDL2) (AA 229-258) antibody HSDL2 Reactivity: Human WB Host: Rabbit Polyclonal ... anti-Hydroxysteroid Dehydrogenase Like 2 (HSDL2) antibody HSDL2 Reactivity: Human, Mouse, Rat ELISA, IF, IHC, WB Host: Rabbit ...

https://www.antibodies-online.com/antibody/529627/anti-Hydroxysteroid+Dehydrogenase+Like+2+HSDL2+AA+1-418+antibody/

Human HSD11b1(11-Beta-Hydroxysteroid Dehydrogenase Type 1) ELISA Kit Human HSD11b1(11-Beta-Hydroxysteroid Dehydrogenase Type 1 ... Human HSD11b1(11-Beta-Hydroxysteroid Dehydrogenase Type 1) ELISA Kit. *Human HSD17b14(17-Beta-Hydroxysteroid Dehydrogenase Type ... Human 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) ELISA Kit. SEC268Hu-1x48wellstestplate Cloud-Clone 1x48-wells test ... Human 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) ELISA Kit. SEC268Hu-1x96wellstestplate Cloud-Clone 1x96-wells test ...

https://lipidx.org/human-hsd11b111-beta-hydroxysteroid-dehydrogenase-type-1-elisa-kit/

17-beta-hydroxysteroid dehydrogenase-like protein Feature Type. ORF , Verified Experimental Data Contains experimentally- ... This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. These ...

https://www.yeastgenome.org/locus/S000000260/protein

Dive into the research topics of 17, 20β-Dihydroxy-4-pregnen-3-one. Together they form a unique fingerprint. ...

https://kyushu-u.pure.elsevier.com/en/publications/17-20%CE%B2-dihydroxy-4-pregnen-3-one/fingerprints/?sortBy=alphabetically

Of particular interest, analysis of steroidogenesis marker 3β-Hydroxysteroid dehydrogenase (3β-HSD) reveals differential ... Protein localisation of 20 alpha-HSD (Red) in the developing postnatal adrenal. It can be seen that from d12 that the X-zone in ... Investigation of 20-α-hydroxysteroid dehydrogenase (20 alpha-HSD, produced by the mouse Akr1c18 gene), an X-zone specific ... We established that this Cre line targets less than 20% of testicular Leydig cells22 and that loss of AR from Leydig cells has ...

https://www.nature.com/articles/s41598-019-46049-3?error=cookies_not_supported&code=70b48b2d-bb46-4bac-873d-a7f4d91d5f1b

Sen S, Bhattacharya S. Hormonal influence on perch ovarian 17 beta-hydroxysteroid dehydrogenase activity in in vitro system. ... Hormonal influence on perch ovarian 17 beta-hydroxysteroid dehydrogenase activity in in vitro system. ...

https://imsear.searo.who.int/handle/123456789/60802

... α-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines," Biological and Pharmaceutical Bulletin ... α-hydroxysteroid dehydrogenase [64]. Currently, mouse model studies are investigating the prospect that reduced levels of ... N. Usami, T. Yamamoto, S. Shintani et al., "Substrate specificity of human 3(20) ... 20-25]. During embryonic development, SHH is covalently modified with both palmitate and cholesterol and secreted as part of a ...

https://www.hindawi.com/journals/aurt/2011/653570/

3-beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare genetic disorder of steroid biosynthesis that results in ... mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five ... encoded search term (3-Beta-Hydroxysteroid Dehydrogenase Deficiency) and 3-Beta-Hydroxysteroid Dehydrogenase Deficiency What to ... 3-Beta-Hydroxysteroid Dehydrogenase Deficiency Differential Diagnoses. Updated: Jun 16, 2016 * Author: J Paul Frindik, MD, FACE ...

https://emedicine.staging.medscape.com/article/920621-differential

11β-Hydroxysteroid Dehydrogenase (Type 2) Blocking Peptide 154-10242 WB 200 µg ...

https://nordicbiosite.com/products?filterName=productType.keyword&filterValue=Proteins%20%26%20Peptides&excludeName=application.keyword&excludeValue=IM

Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ... The crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase (HSD)/bile acid binding protein (AKR1C2) complexed ... The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of ... Known as: 3 alpha,15 beta,17 alpha-trihydroxy-5 beta-pregnan-20-one, 3,15,17-TH-5P, 3,15,17-trihydoxy-5alpha-pregnan-20-one ...

https://www.semanticscholar.org/topic/3%2C15%2C17-trihydroxypregnan-20-one/5996504

Human 17-Beta-Hydroxysteroid Dehydrogenase Type 14 (HSD17b14) ELISA Kit, Cat#EKU02009. Write a Review Write a Review. × ... 17-Beta-Hydroxysteroid Dehydrogenase Type 14. Target Synonyms. DHRS10; RetSDR3, SDR47C1; Retinal Short-Chain Dehydrogenase/ ... Human 17-Beta-Hydroxysteroid Dehydrogenase Type 14 (HSD17b14) ELISA Kit, Cat#EKU02009 ... Human 17-Beta-Hydroxysteroid Dehydrogenase Type 14 (HSD17b14) ELISA Kit, Cat#EKU02009. ...

https://www.biomatik.com/elisa-kits/human-17-beta-hydroxysteroid-dehydrogenase-type-14-hsd17b14-elisa-kit-cat-eku02009/

3α-Hydroxysteroid dehydrogenase, type II AKR1C4 Dihydrodiol dehydrogenase 4; chlordecone reductase; 3α-hydroxysteroid ... Dihydrodiol dehydrogenase 2; 3α-Hydroxysteroid dehydrogenase, type III AKR1C3 ... Dihydrodiol dehydrogenase I; 20α,(3α)-Hydroxysteroid dehydrogenase AKR1C2 ...

https://humgenomics.biomedcentral.com/articles/10.1186/1479-7364-3-4-362/tables/1

He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and ... in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine". J ...

https://www.wikidoc.org/index.php/Interleukin_3

Upon ligand-induced activation of the major circulating androgen, testosterone 8. 17 -hydroxysteroid dehy- drogenase deficiency ... A powerful developing nations during the can vary for a lost soldier which portray usually aged between 21 and 20 years ities ... eye branch of intercostal nerves depress ribs thoracis lower sternum costal cartilages for vertebral 7 12 20 19 5 7 years of ...

https://www.psm.edu/package/viagra-ratiopharm-bestellen/89/

11-Beta hydroxylase deficiency, 3-beta hydroxysteroid dehydrogenase deficiency, and 17 alpha-hydroxylase/17,20-lyase deficiency ... However, once the GFR falls below 15-20 mL/min, significant hyperkalemia can occur, even in the absence of an abnormally large ... 1] Chronic kidney disease alone generally will not cause hyperkalemia until the eGFR is less than 20-25 mL/min. ... decreases to less than 15-20 mL/min. Additionally, in the presence of kidney failure, the proportion of potassium excreted ...

https://reference.medscape.com/article/240903-overview

Purification and characterization of rat ovarian 20α-hydroxysteroid dehydrogenase. Noda, K., Shiota, K. & Takahashi, M., 1991 ...

https://waseda.pure.elsevier.com/ja/publications/?page=1430&ordering=publicationYearThenTitle&descending=true&showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=

Inactivators and Site-Directed Mutagenesis as Probes for Steroid Hormone Recognition by 3α-Hydroxysteroid Dehydrogenase. ... Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase. Auchus, R. J., Palmer, J. O., ... Solid-state NMR observatioon of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase. Asuchus, R. J., ... Shen, W., Mennerick, S., Covey, D. F. & Zorumski, C. F., May 15 2000, In: Journal of Neuroscience. 20, 10, p. 3571-3579 9 p.. ...

https://profiles.wustl.edu/en/persons/douglas-covey/publications/?ordering=type&descending=true&page=5

New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzym. (medscape.com)
Subramaniam P, Clayton PT, Portmann BC, Mieli-Vergani G, Hadzic N. Variable clinical spectrum of the most common inborn error of bile acid metabolism--3beta-hydroxy-Delta 5-C27-steroid dehydrogenase deficiency. (medscape.com)
Simard J, Moisan AM, Morel Y. Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency. (medscape.com)
Persistent testicular delta5-isomerase-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) deficiency in the delta5-3beta-HSD form of congenital adrenal hyperplasia. (medscape.com)
3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. (medscape.com)
Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature. (medscape.com)
Delayed diagnosis of congenital adrenal hyperplasia with salt wasting due to type II 3beta-hydroxysteroid dehydrogenase deficiency. (medscape.com)
Nordenström A, Forest MG, Wedell A. A case of 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) deficiency picked up by neonatal screening for 21-hydroxylase deficiency: difficulties and delay in etiologic diagnosis. (medscape.com)
Jeandron DD, Sahakitrungruang T. A novel homozygous Q334X mutation in the HSD3B2 gene causing classic 3ß-hydroxysteroid dehydrogenase deficiency: an unexpected diagnosis after a positive newborn screen for 21-hydroxylase deficiency. (medscape.com)
Detection and functional characterization of the novel missense mutation Y254D in type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) gene of a female patient with nonsalt-losing 3 beta HSD deficiency. (medscape.com)
17 -hydroxysteroid dehy- drogenase deficiency (28). (psm.edu)
[3] In patients with congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency 17-OH-pregnenolone is increased, while in patients with congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency levels are low to absent. (chemeurope.com)
46,XY individuals with complete 17 α -hydroxylase/17,20-lyase deficiency may present in adolescence with hypertension and delayed puberty. (unboundmedicine.com)

Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia. (medscape.com)

High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling. (abnova.com)
IMSEAR at SEARO: Hormonal influence on perch ovarian 17 beta-hydroxysteroid dehydrogenase activity in in vitro system. (who.int)
The present mini-review focuses on the 46,XX individual, with emphasis on recent advances in knowledge pertaining to ovarian development and related abnormalities. (hormones.gr)

Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls. (medscape.com)

Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. (semanticscholar.org)

This section also contains protein abundance data for both untreated and treated cells obtained from over 20 studies. (yeastgenome.org)
The mRNA expression of several possible regulatory factors was investigated, revealing the suppression of PGF2α receptor (PTGFR), steroidogenic acute regulatory protein (STAR) and 3β-hydroxysteroid dehydrogenase (3βHSD), compared with controls and subsequent cycles. (uzh.ch)
As with aging, decreases were seen in LH-stimulated cAMP production, steroidogenic acute regulatory protein, cholesterol side-chain cleavage, 3β-hydroxysteroid dehydrogenase, and 17α-hydroxylase/17,20-lyase. (elsevier.com)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) in tissue homogenates, cell lysates and other biological fluids. (lipidx.org)
Speckle-targeting component (STE) series was inserted in to the 3 of -globin cDNA to create -globin cDNA-STE (cG-STE). Antibody to UAP56, CBP80 and ARS2 had been referred to (9 previously,20). (biotech2012.org)

This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. (abnova.com)
The enzyme 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni was crystallized. (ox.ac.uk)
In the inflamed synovium, cortisol is generated from cortisone by the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. (biomedcentral.com)

Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. (medscape.com)

Studies of 3 beta-hydroxysteroid dehydrogenase genes in infants and children manifesting premature pubarche and increased adrenocorticotropin-stimulated delta 5-steroid levels. (medscape.com)

He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3. (wikidoc.org)

Crystallization and crystal packing of recombinant 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni ATTC 11996. (ox.ac.uk)

This assay has high sensitivity and excellent specificity for detection of 17-Beta-Hydroxysteroid Dehydrogenase Type 14 (HSD17b14). (biomatik.com)
No significant cross-reactivity or interference between 17-Beta-Hydroxysteroid Dehydrogenase Type 14 (HSD17b14) and analogues was observed. (biomatik.com)

17-hydroxypregneolone is also converted to 17-hydroxyprogesterone , a prohomone for glucocorticosteroids and androstenedione through the activity of 3-hydroxysteroid dehydrogenase. (chemeurope.com)

Associations between red cell glucose-6-phosphate dehydrogenase variants and vascular diseases. (elsevier.com)
The presence of 11β hydroxysteroid dehydrogenase in vascular tissue has been documented. (smarthsurfaces.com)

RoidsMall is giving you 20% off on selective brands in our Black Friday season sale! (restarajasthan.com)

PDB-4fam: Crystal structure of human 17beta-hydroxysteroid dehydrogenase ty. (pdbj.org)

A molecular replacement search carried out by using 3 alpha (or 20 beta)-hydroxysteroid dehydrogenase from Streptomyces hydrogenans as a search model allowed us to assign I222 as the correct space group and to propose a model for the crystal packing, with one monomer per asymmetric unit. (ox.ac.uk)

However, only 15-20% of patients with DSDs are diagnosed at the molecular level. (unboundmedicine.com)

Epidemiological data show that the prevalence of obesity has significantly increased over the past 20 years and continues to do so at an alarming rate. (diabetesjournals.org)
As such, our views of adipose tissue have changed significantly over the past 20 years. (diabetesjournals.org)

Se cree que la depresión post-parto (DPP) causa una variedad de problemas del desarrollo, incluyendo alteraciones funcionales en el eje hypotálamo-hipofisario-adrenal (HHA). (bvsalud.org)

Historical studies using castrated mice show that removal of circulating androgens leads to the redevelopment of an additional cortex zone known as the transient X-zone 20 . (nature.com)

Superior thoracic artery clavicular branch thyrocervical trunk vagus n. (cn vii) eye branch of intercostal nerves depress ribs thoracis lower sternum costal cartilages for vertebral 7 12 20 19 5 7 years of age more common than subarachnoid saccular (berry) aneurysms, carotid cavernous sinus cannot abduct the fingers (pad). (psm.edu)
1 In the United States, 25.8 million Americans have diabetes, and another 79 million US adults aged ≥20 years are considered to have prediabetes. (ahdbonline.com)

Approximately 10-20% of low-risk patients without metastases and 30-50% of metastatic patients with low risk develop single-agent chemotherapeutic resistance and require multi-agent chemotherapy to achieve complete remission. (medsci.org)
Furthermore, ~20-30% of high-risk patients have an incomplete response to first-line multi-agent chemotherapy [ 5 - 8 ]. (medsci.org)
A total of twenty-six patients received 1·44 g Lingzhi daily or matching placebo for 12 weeks in a randomised, double-blind, cross-over study with placebo-controlled run-in and cross-over periods. (cambridge.org)
Ensure the patients' samples, calibrators, and controls are at ambient temperature (20-25°C) before measurement. (cdc.gov)

Others possess recommended that DUOX1 in lung epithelia may are likely involved in web host defence [20] and silencing of and their particular maturation factors continues to be confirmed in lung cancers cells [21]. (researchensemble.com)

ANIMALS: One hundred twenty-one cats with TT4 ≥40 nmol/L after treatment with RAI (out of an original, treated study sample of 959 cats). (bvsalud.org)

In this mini-review, recent advances concerning development of the genital system in 46,XX individuals and related abnormalities are discussed. (hormones.gr)

Store at -20°C or lower. (abnova.com)
a 20-fold increase in lower limb amputations , and increased rates of hospitalizations. (thediabeticpharmacist.com)

The expression of TLR2 and TLR4, interleukin (IL) 1α and IL1β, and of PGF2α and PGE2 synthases (20αHSD/PGFS and mPTGES, respectively) was increased. (uzh.ch)

Anatomy1

Diseases1

Chemicals and Drugs60

Phenomena and Processes7

Information Science3

Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile. (1/103)

26-cholesterol hydroxylase in rat corpora lutea: A negative regulator of progesterone secretion. (2/103)

Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins. (3/103)

Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. (4/103)

Characterization of a human 20alpha-hydroxysteroid dehydrogenase. (5/103)

The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. (6/103)

Characterization of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of human recombinant 11-cis-retinol dehydrogenase. (7/103)

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. (8/103)

Hydroxysteroid Dehydrogenases

3-Hydroxysteroid Dehydrogenases

17-Hydroxysteroid Dehydrogenases

20-Hydroxysteroid Dehydrogenases

3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)

11-beta-Hydroxysteroid Dehydrogenase Type 2

11-beta-Hydroxysteroid Dehydrogenase Type 1

11-beta-Hydroxysteroid Dehydrogenases

Estradiol Dehydrogenases

Sulfotransferases

Cortisone

Steroid 17-alpha-Hydroxylase

Alcohol Oxidoreductases

Steroids

NAD

Hydrocortisone

L-Lactate Dehydrogenase

Testosterone

Kinetics

Androsterone

Liver

Alcohol Dehydrogenase

Glyceraldehyde-3-Phosphate Dehydrogenases

20-alpha-Hydroxysteroid Dehydrogenase

Aldehyde Dehydrogenase

Glutamate Dehydrogenase

Glucosephosphate Dehydrogenase

Malate Dehydrogenase

Isocitrate Dehydrogenase

Phosphoadenosine Phosphosulfate

Arylsulfotransferase

Ketosteroids

Dihydrolipoamide Dehydrogenase

NADP

Carbohydrate Dehydrogenases

Succinate Dehydrogenase

L-Iditol 2-Dehydrogenase

Dehydroepiandrosterone

Glycerolphosphate Dehydrogenase

Substrate Specificity

Glucose 1-Dehydrogenase

Molecular Sequence Data

Ketoglutarate Dehydrogenase Complex

Aldehyde Oxidoreductases

Glucose Dehydrogenases

Phosphogluconate Dehydrogenase

Sugar Alcohol Dehydrogenases

Stereoisomerism

Acyl-CoA Dehydrogenases

NADH Dehydrogenase

IMP Dehydrogenase

Amino Acid Sequence

Lactate Dehydrogenases

Gene Expression Regulation, Enzymologic

Isoenzymes

Formate Dehydrogenases

Acyl-CoA Dehydrogenase

Xanthine Dehydrogenase

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)

Hydroxybutyrate Dehydrogenase

Base Sequence

Pyruvate Dehydrogenase (Lipoamide)

3-Hydroxyacyl CoA Dehydrogenases

Ketone Oxidoreductases

Oxidoreductases

Sulfates

Dihydrouracil Dehydrogenase (NADP)

Uridine Diphosphate Glucose Dehydrogenase

Catalysis

Glucosephosphate Dehydrogenase Deficiency

Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile. (1/103)

26-cholesterol hydroxylase in rat corpora lutea: A negative regulator of progesterone secretion. (2/103)

Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins. (3/103)

Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. (4/103)

Characterization of a human 20alpha-hydroxysteroid dehydrogenase. (5/103)

The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. (6/103)

Characterization of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of human recombinant 11-cis-retinol dehydrogenase. (7/103)

Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. (8/103)

Characterisation of a novel mouse liver aldo-keto reductase AKR7A5 - Strathprints

Recombinant Human AKR1C1, His-tagged AKR1C1-27157TH - Creative BioMart