1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.2-Naphthylamine: A naphthalene derivative with carcinogenic action.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.DiethylaminesDimethylaminesChemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hydroxylamines: Organic compounds that contain the (-NH2OH) radical.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Aminobiphenyl Compounds: Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.Benzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Sulfonic Acids: Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Chromatography, Paper: An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Phenoxypropanolamines: Compounds based on a propanolamine attached via an OXYGEN atom to a phenoxy ring. The side chain is one carbon longer than PHENYLETHYLAMINES.Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Occupational Diseases: Diseases caused by factors involved in one's employment.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Hydroxyethyl Starch Derivatives: Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Software: Sequential operating programs and data which instruct the functioning of a digital computer.One-Carbon Group Transferases: A subclass of transferases that transfer chemical groups containing a single carbon. These include the METHYLTRANSFERASES, the HYDROXYMETHYL AND FORMYL TRANSFERASES, the CARBOXYL AND CARBAMOYL TRANSFERASES, and the AMIDINOTRANSFERASES. EC 2.1.Receptors, Interleukin-8: Cell surface receptors that are specific for INTERLEUKIN-8. Two specific receptor subtypes (type A and B) have been found and bind IL-8 with high affinity.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Musculoskeletal Diseases: Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.Great BritainRisk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.EthaneHydrocarbons, HalogenatedHydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)PropaneAlkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Czechoslovakia: Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.Libya: A country in northern Africa, bordering the Mediterranean Sea, between Egypt, Tunisia, and Algeria, having southern border with Chad, Niger, and Sudan. Its capital is Tripoli.Czech Republic: Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.Explosive Agents: Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)VietnamTrinitrotoluene: A 2,4,6-trinitrotoluene, which is an explosive chemical that can cause skin irritation and other toxic consequences.

Fluorescence studies of the carboxyl-terminal domain of smooth muscle calponin effects of F-actin and salts. (1/241)

The fluorescence parameters of the environment-sensitive acrylodan, selectively attached to Cys273 in the C-terminal domain of smooth muscle calponin, were studied in the presence of F-actin and using varying salt concentrations. The formation of the F-actin acrylodan labeled calponin complex at 75 mm NaCl resulted in a 21-nm blue shift of the maximum emission wavelength from 496 nm to 474 nm and a twofold increase of the fluorescent quantum yield at 460 nm. These spectral changes were observed at the low ionic strengths (< 110 mm) where the calponin : F-actin stoichiometry is 1 : 1 as well as at the high ionic strengths (> 110 mm) where the binding stoichiometry is a 1 : 2 ratio of calponin : actin monomers. On the basis of previous three-dimensional reconstruction and chemical crosslinking of the F-actin-calponin complex, the actin effect is shown to derive from the low ionic strength interaction of calponin with the bottom of subdomain-1 of an upper actin monomer in F-actin and not from its further association with the subdomain-1 of the adjacent lower monomer which occurs at the high ionic strength. Remarkably, the F-actin-dependent fluorescence change of acrylodan is qualitatively but not quantitatively similar to that earlier reported for the complexes of calponin and Ca2+-calmodulin or Ca2+-caltropin. As the three calponin ligands bind to the same segment of the protein, encompassing residues 145-182, the acrylodan can be considered as a sensitive probe of the functioning of this critical region. A distance of 29 A was measured by fluorescence resonance energy transfer between Cys273 of calponin and Cys374 of actin in the 1 : 1 F-actin-calponin complex suggesting that the F-actin effect was allosteric reflecting a global conformational change in the C-terminal domain of calponin.  (+info)

Cysteine-scanning mutagenesis of an eukaryotic pore-forming toxin from sea anemone: topology in lipid membranes. (2/241)

Equinatoxin II is a cysteineless pore-forming protein from the sea anemone Actinia equina. It readily creates pores in membranes containing sphingomyelin. Its topology when bound in lipid membranes has been studied using cysteine-scanning mutagenesis. At approximately every tenth residue, a cysteine was introduced. Nineteen single cysteine mutants were produced in Escherichia coli and purified. The accessibility of the thiol groups in lipid-embedded cysteine mutants was studied by reaction with biotin maleimide. Most of the mutants were modified, except those with cysteines at positions 105 and 114. Mutants R144C and S160C were modified only at high concentrations of the probe. Similar results were obtained if membrane-bound biotinylated mutants were tested for avidin binding, but in this case three more mutants gave a negative result: S1C, S13C and K43C. Furthermore, mutants S1C, S13C, K20C, K43C and S95C reacted with biotin only after insertion into the lipid, suggesting that they were involved in major conformational changes occurring upon membrane binding. These results were further confirmed by labeling the mutants with acrylodan, a polarity-sensitive fluorescent probe. When labeled mutants were combined with vesicles, the following mutants exhibited blue-shifts, indicating the transfer of acrylodan into a hydrophobic environment: S13C, K20C, S105C, S114C, R120C, R144C and S160C. The overall results suggest that at least two regions are embedded within the lipid membrane: the N-terminal 13-20 region, probably forming an amphiphilic helix, and the tryptophan-rich 105-120 region. Arg144, Ser160 and residues nearby could be involved in making contacts with lipid headgroups. The association with the membrane appears to be unique and different from that of bacterial pore-forming proteins and therefore equinatoxin II may serve as a model for eukaryotic channel-forming toxins.  (+info)

ATP-induced opposite changes in the local environments around Cys(697) (SH2) and Cys(707) (SH1) of the myosin motor domain revealed by the prodan fluorescence. (3/241)

To obtain a consistent view of the nucleotide-induced conformational changes around Cys(697) (SH2) and Cys(707) (SH1) in skeletal myosin subfragment-1 (S-1), the two thiols were labeled with the same environmentally sensitive fluorophore, 6-acyl-2-dimethylaminonaphthalene group, using 6-acryloyl-2-dimethylaminonaphthalene (acrylodan, AD) and 6-bromoacetyl-2-dimethylaminonaphthalene (BD), respectively. The resultant fluorescent derivatives, AD-S-1 and BD-S-1, have the same fluorophore at either SH2 or SH1, which was verified by inspections of changes in the ATPases and the localization of fluorescence after tryptic digestion and CNBr cleavage for the two derivatives. Especially, AD was found to be a very useful fluorescent reagent that readily reacts with only SH2 of S-1. Measurements of the nucleotide-induced changes in fluorescence emission spectra of AD-S-1 and BD-S-1 suggested that during ATP hydrolysis the environment around the fluorophore at SH2 is very distinct from that around the fluorophore at SH1, being defined as that the former has the hydrophobic and closed characteristics, whereas the latter has the hydrophilic and open ones. The KI quenching study of the fluorescence of the two S-1 derivatives confirmed these results. The most straightforward interpretation for the present results is that during ATP hydrolysis, the helix containing SH2 is buried in hydrophobic side chains and rather reinforced, whereas the adjacent helix containing SH1 moves away from its stabilizing tertiary structural environment.  (+info)

Two-photon fluorescence microscopy observation of shape changes at the phase transition in phospholipid giant unilamellar vesicles. (4/241)

Using the sectioning effect of the two-photon fluorescence microscope, we studied the behavior of phospholipid giant unilamellar vesicles (GUVs) composed of pure diacylphosphatidylcholine phospholipids during the gel-to-liquid crystalline phase transition. We used the well-characterized excitation generalized polarization function (GP(ex)) of 6-dodecanoyl-2-dimethylamine-naphthalene (LAURDAN), which is sensitive to the changes in water content in the lipid vesicles, to monitor the phase transition in the GUVs. Even though the vesicles do not show temperature hysteresis at the main phase transition, we observed different behaviors of the vesicle shape, depending on how the GUV sample reaches the main phase transition. During the cooling cycles, we observed an increase in the vesicle diameter at the phase transition ( approximately 0.5-1%), followed by a decrease in the diameter when the vesicle reached the gel phase. During the heating cycles and close to the phase transition temperature, a surprising behavior is observed, showing a sequence of different vesicle shapes as follows: spherical-polygonal-ellipsoidal. We attribute these changes to the effect of lipid domain coexistence on the macroscopic structure of the GUVs. The "shape hysteresis" in the GUVs is reversible and largely independent of the temperature scan rate. In the presence of 30 mol% of cholesterol the events observed at the phase transition in the GUVs formed by pure phospholipids were absent.  (+info)

Hydration of lipoplexes commonly used in gene delivery: follow-up by laurdan fluorescence changes and quantification by differential scanning calorimetry. (5/241)

Lipoplexes, which are formed spontaneously between cationic liposomes and negatively charged nucleic acids, are commonly used for gene and oligonucleotide delivery in vitro and in vivo. Being assemblies, lipoplexes can be characterized by various physicochemical parameters, including size distribution, shape, physical state (lamellar, hexagonal type II and/or other phases), sign and magnitude of electrical surface potential, and level of hydration at the lipid-DNA interface. Only after all these variables will be characterized for lipoplexes with a broad spectrum of lipid compositions and DNA/cationic lipid (L(+)) mole (or charge) ratios can their relevance to transfection efficiency be understood. Of all these physicochemical parameters, hydration is the most neglected, and therefore the focus of this study. Cationic liposomes composed of DOTAP without and with helper lipids (DOPC, DOPE, or cholesterol) or of DC-Chol/DOPE were complexed with pDNA (S16 human growth hormone) at various DNA(-)/L(+) charge ratios (0.1-3.2). (DOTAP=N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride; DC-Chol=(3beta-[N-(N',N'-dimethylaminoethane)-carbamoyl]-cholester ol; DOPC=1, 2-dioleoyl-sn-glycero-3-phosphocholine; DOPE=1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine). The hydration levels of the different cationic liposomes and the DNA separately are compared with the hydration levels of the lipoplexes. Two independent approaches were applied to study hydration. First, we used a semi-quantitative approach of determining changes in the 'generalized polarization' (GP) of laurdan (6-dodecanoyl-2-dimethylaminonaphthalene). This method was recently used extensively and successfully to characterize changes of hydration at lipid-water interfaces. Laurdan excitation GP at 340 nm (GP(340)DOTAP. The GP(340) of lipoplexes of all lipid compositions (except those based on DC-Chol/DOPE) was higher than the GP(340) of the cationic liposomes alone and increased with increasing DNA(-)/L(+) charge ratio, reaching a plateau at a charge ratio of 1. 0, suggesting an increase in dehydration at the lipid-water interface with increasing DNA(-)/L(+) charge ratio. Confirmation was obtained from the second method, differential scanning calorimetry (DSC). DOTAP/DOPE lipoplexes with charge ratio 0.44 had 16.5% dehydration and with charge ratio 1.5, 46.4% dehydration. For DOTAP/Chol lipoplexes with these charge ratios, there was 17.9% and 49% dehydration, respectively. These data are in good agreement with the laurdan data described above. They suggest that the dehydration occurs during lipoplex formation and that this is a prerequisite for the intimate contact between cationic lipids and DNA.  (+info)

Electrostatic properties of membranes containing acidic lipids and adsorbed basic peptides: theory and experiment. (6/241)

The interaction of heptalysine with vesicles formed from mixtures of the acidic lipid phosphatidylserine (PS) and the zwitterionic lipid phosphatidylcholine (PC) was examined experimentally and theoretically. Three types of experiments showed that smeared charge theories (e.g., Gouy-Chapman-Stern) underestimate the membrane association when the peptide concentration is high. First, the zeta potential of PC/PS vesicles in 100 mM KCl solution increased more rapidly with heptalysine concentration (14.5 mV per decade) than predicted by a smeared charge theory (6.0 mV per decade). Second, changing the net surface charge density of vesicles by the same amount in two distinct ways produced dramatically different effects: the molar partition coefficient decreased 1000-fold when the mole percentage of PS was decreased from 17% to 4%, but decreased only 10-fold when the peptide concentration was increased to 1 microM. Third, high concentrations of basic peptides reversed the charge on PS and PC/PS vesicles. Calculations based on finite difference solutions to the Poisson-Boltzmann equation applied to atomic models of heptalysine and PC/PS membranes provide a molecular explanation for the observations: a peptide adsorbing to the membrane in the presence of other surface-adsorbed peptides senses a local potential more negative than the average potential. The biological implications of these "discreteness-of-charge" effects are discussed.  (+info)

Two photon fluorescence microscopy of coexisting lipid domains in giant unilamellar vesicles of binary phospholipid mixtures. (7/241)

Images of giant unilamellar vesicles (GUVs) formed by different phospholipid mixtures (1,2-dipalmitoyl-sn-glycero-3-phosphocholine/1, 2-dilauroyl-sn-glycero-3-phosphocholine (DPPC/DLPC) 1:1 (mol/mol), and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine/1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPE/DPPC), 7:3 and 3:7 (mol/mol) at different temperatures were obtained by exploiting the sectioning capability of a two-photon excitation fluorescence microscope. 6-Dodecanoyl-2-dimethylamino-naphthalene (LAURDAN), 6-propionyl-2-dimethylamino-naphthalene (PRODAN), and Lissamine rhodamine B 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (N-Rh-DPPE) were used as fluorescent probes to reveal domain coexistence in the GUVs. We report the first characterization of the morphology of lipid domains in unsupported lipid bilayers. From the LAURDAN intensity images the excitation generalized polarization function (GP) was calculated at different temperatures to characterize the phase state of the lipid domain. On the basis of the phase diagram of each lipid mixture, we found a homogeneous fluorescence distribution in the GUV images at temperatures corresponding to the fluid region in all lipid mixtures. At temperatures corresponding to the phase coexistence region we observed lipid domains of different sizes and shapes, depending on the lipid sample composition. In the case of GUVs formed by DPPE/DPPC mixture, the gel DPPE domains present different shapes, such as hexagonal, rhombic, six-cornered star, dumbbell, or dendritic. At the phase coexistence region, the gel DPPE domains are moving and growing as the temperature decreases. Separated domains remain in the GUVs at temperatures corresponding to the solid region, showing solid-solid immiscibility. A different morphology was found in GUVs composed of DLPC/DPPC 1:1 (mol/mol) mixtures. At temperatures corresponding to the phase coexistence, we observed the gel domains as line defects in the GUV surface. These lines move and become thicker as the temperature decreases. As judged by the LAURDAN GP histogram, we concluded that the lipid phase characteristics at the phase coexistence region are different between the DPPE/DPPC and DLPC/DPPC mixtures. In the DPPE/DPPC mixture the coexistence is between pure gel and pure liquid domains, while in the DLPC/DPPC 1:1 (mol/mol) mixture we observed a strong influence of one phase on the other. In all cases the domains span the inner and outer leaflets of the membrane, suggesting a strong coupling between the inner and outer monolayers of the lipid membrane. This observation is also novel for unsupported lipid bilayers.  (+info)

A further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special reference to the chemicals 2-mercaptobenzothiazole (MBT), aniline, phenyl-beta-naphthylamine and o-toluidine. (8/241)

OBJECTIVES: To investigate mortality and cancer morbidity in workers from a factory manufacturing chemicals for the rubber industry. METHODS: The mortality (1955-96) and cancer morbidity experience (1971-92) of a cohort of 2160 male production workers from a chemical factory in north Wales were investigated. All subjects had at least 6 months employment at the factory and some employment in the period 1955-84. Detailed job histories were abstracted from company computerised records and estimates of individual cumulative exposure to 2-mercaptobenzothiazole (MBT) and its derivatives were obtained, with a job exposure matrix derived by a former factory hygienist. Durations of employment in the aniline, phenyl-beta-naphthylamine (PBN) and o-toluidine departments were also calculated. Two analytical approaches were used, indirect standardisation and Poisson regression. RESULTS: Based on serial rates for the general population of England and Wales, observed mortality for the total cohort was close to expectation for all causes (observed (obs) deaths 1131, expected (exp) deaths 1114.5, standardised mortality ratio (SMR) 101), and for all cancers (obs 305, exp 300.2, SMR 102). There was a significant (p < 0.05) excess mortality from cancer of the bladder in the 605 study subjects potentially exposed to one or more of the four chemicals being investigated (obs 9, exp 3.25, SMR 277, 95% confidence interval (95% CI) 127 to 526). This excess was dependent primarily on deaths occurring > 20 years after first exposure in those who started employment before 1955 (obs 7, exp 1.25, SMR 560, 95% CI 225 to 1154, p < 0.001). There were 30 subjects in the total study cohort who, on the basis of death certificates or cancer registration particulars, had had malignant bladder cancer. In separate analyses of the four exposure history variables (after adjustment for age), Poisson regression showed significant positive trends for risk of notification of bladder cancer increasing with cumulative duration of employment in the PBN (p < 0.001) and o-toluidine departments (p < 0.01); similar findings were not obtained for cumulative exposure to MBT or for duration of employment in the aniline department. In a simultaneous analysis of all four chemical exposure variables, a significant positive trend remained for duration of employment with exposure to PBN (p < 0.05). Further analyses of all cases of bladder cancer (malignant and benign diagnoses) used employment histories lagged by 15 years; similar findings were obtained. CONCLUSIONS: It seems likely that some members of this cohort have had occupational bladder cancer. Confident interpretation is difficult because of small numbers in the exposed subcohorts, relatively crude measures of exposure assessment for the four chemicals under study, and presence of unconsidered potential chemical confounders. The simplest interpretation of the findings about bladder cancer may be that PBN (or a chemical reagent or chemical intermediate associated with its production at this factory in the 1930s and 1940s) is a bladder carcinogen. Priority should be given, however, to obtaining information on the cancer experience of other working populations exposed to PBN or to o-toluidine.  (+info)

TY - JOUR. T1 - Phase-fluorometry study on dielectric relaxation of acrylodan-labeled human serum albumin. AU - Buzády, Andrea. AU - Erostyák, János. AU - Somogyi, B.. PY - 2001/12/11. Y1 - 2001/12/11. N2 - Dielectric relaxation (DR) of acrylodan-labeled human serum albumin (HSA/AC) was studied by phase-fluorometry. A non-monoexponential behavior of both the total fluorescence - and the DR decays has been found. The protein environment of the fluorescent marker shows DR times ranging from the pico to nanosecond timescale. In fluorescence emission decays measured on the red side of the fluorescence spectrum a time constant (. AB - Dielectric relaxation (DR) of acrylodan-labeled human serum albumin (HSA/AC) was studied by phase-fluorometry. A non-monoexponential behavior of both the total fluorescence - and the DR decays has been found. The protein environment of the fluorescent marker shows DR times ranging from the pico to nanosecond timescale. In fluorescence emission decays measured on the ...
Physicochemical properties of the plasma membrane have been shown to play an important role in cellular functionality. Among those properties, the molecular order of the lipids, or the lipid packing, is of high importance. Changes in lipid packing are believed to compartmentalize cellular signaling by initiating coalescence and conformational changes of proteins. A common way to infer membrane lipid packing is by using membrane-embedded polarity-sensitive dyes, whose emission spectrum is dependent on the molecular order of the immediate membrane environment. Here, we report on an improved determination of such spectral shifts in the emission spectrum of the polarity-sensitive dyes. This improvement is based on the use of spectral imaging on a scanning confocal fluorescence microscope in combination with an improved analysis, which considers the whole emission spectrum instead of just single wavelength ranges. Using this approach and the polarity-sensitive dyes C-Laurdan or Di-4-ANEPPDHQ, we were able to
Menurunkan pelangsing teh kesehatan hijau yang manfaat di teh sering dapat herbal turun menurunkan berat dari badan hijau badan konsumsi hijau diketahui hijau tubuh kesehatan secara dan alami anda harga daun hijau usah pengobatan sedang berat hijau adalah berguna menurunkan teh menurunkan berat banyak sebagai badan berat benarkah yang teh bagi cara teh teh alami jerawat menghilangkan orang dan diet badan sedang berat hitam lho teh bukan teh manfaat minum teh segar tahukah baik bahan hijau melangingkan hal menawarkan dan bingung kesehatan bagi dengan diet sering Khasiat Teh Hijau untuk Menurunkan Berat Badan salah tentang manfaat alami teh orang yang manfaat berbagai tubuh normal untuk membantu antara mempunyai dikenal dipetik alami badan Khasiat Teh Hijau untuk Menurunkan Berat Badan menurunkan berat depok khasiat teh hijau untuk penurunan berat badan akan kesehatan tanaman badan yang mempunyai hitam buah alami des manfaat nov sekali merupakan teh hijau juga manfaat tetapi saja aku teh saran ...
Menurunkan pelangsing teh kesehatan hijau yang manfaat di teh sering dapat herbal turun menurunkan berat dari badan hijau badan konsumsi hijau diketahui hijau tubuh kesehatan secara dan alami anda harga daun hijau usah pengobatan sedang berat hijau adalah berguna menurunkan teh menurunkan berat banyak sebagai badan berat benarkah yang teh bagi cara teh teh alami jerawat menghilangkan orang dan diet badan sedang berat hitam lho teh bukan teh manfaat minum teh segar tahukah baik bahan hijau melangingkan hal menawarkan dan bingung kesehatan bagi dengan diet sering Khasiat Teh Hijau untuk Menurunkan Berat Badan salah tentang manfaat alami teh orang yang manfaat berbagai tubuh normal untuk membantu antara mempunyai dikenal dipetik alami badan Khasiat Teh Hijau untuk Menurunkan Berat Badan menurunkan berat depok khasiat teh hijau untuk penurunan berat badan akan kesehatan tanaman badan yang mempunyai hitam buah alami des manfaat nov sekali merupakan teh hijau juga manfaat tetapi saja aku teh saran ...
The binding of chicken gizzard caldesmon to actin was studied both in the presence and the absence of caltropin using Airfuge centrifugation experiments, disulfide cross-linking studies, and the fluorescent probe acrylodan (6-acryloyl-2-(dimethylamino)naphthalene). In co-sedimentation studies most of the caldesmon pelleted along with actin. However, when caldesmon in the presence of caltropin was mixed with actin, caldesmon did not pellet along with actin following high speed centrifugation, suggesting that caltropin has significantly weakened its binding to actin. The caltropin effect was noticed even when tropomyosin was included in the reaction mixture. Acrylodan-labeled caldesmon, when excited at 375 nm, had an emission maximum at 515 +/- 2 nm. The addition of actin produced a nearly 70% increase in fluorescent intensity, accompanied by a blue shift in the emission maximum (i.e. lambda em (max) = 505 +/- 2 nm), suggesting that the probe now occupies a more nonpolar environment. Titration of labeled
Qanjidhka thyroid-ka wuxuu ku yaallaa dhuunta, wuxuuna labada dhinac ka xigaa tuunbada hawa mareenka qeybteeda kore , waxaana uu soo daayaa hormoono wax ku ool u ah shaqada jirka, sida kuwa kontoroola habka loo yaqaano metabolism (habka burburinta ama dhisida nafaqada taasoo jirku u isticmaalo tamar ahaan). Waxaa kale oo ay maamulaanama kontoroolaan shaqooyin kale oo aad u tira badan sida, neefsashada, garaaca wadnaha, neerfayaasha maskaxda iyo xungulaha, miisaanka jirka, awooda murqaha, heer kulka jira iyo cadadka k olesterolka. Marka ay yaraato soo deynta hormoonada laga soo daayo qanjirkaan waxaa ay saamayn balaaran ku yeeshaan dhamaan shaqadii ay qaybta ka ahaayeen.. Dumarka gaar ahaan kuwooda dada weyn ayuu ugu badan yahay xanuunkaan. Inta badan ma sababa wax calaamad ah markuu bilowga yahay. Balse hadii aan la daweyn waxuu keenayaa calaamado ama cilado hor leh sida cayil xad dhaafa, kalagowsyo xanuun, dhalmo laaan iyo xanuuno saamayn ku yeesha wadnaha.. WAA MAXAY CILLADAHA KU DHACDA ...
Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) stimulation causes reduced glutamatergic neuronal activity with a highly correlated reduction in GABA, presumably due to the close biochemical relationship between the two neurotransmitters.
Pemutih badan Fair n pink whitening body serum Pemutih badan dan wajah fair n pink, Memiliki kulit yang putih dan juga bersih memang menjadi idaman semua orang,apalagi para wanita.kebanyakan waniti di indonesia memiliki warna kulit yang berbeda,misalnya kilit wajah tidak sama dengan kulit leher.warna kulit leher tidak saman dengan warna kulit lengan, masalah ini mungkin…
Demam (juga dikenali sebagai pyrexia atau hiperthermia terkawal[1]) merupakan isyarat perubatan biasa dengan cirri-ciri peningkatan suhu melebihi julat biasa 36.5-37.5 °C (97.7-99.5 °F) disebabkan peningkatan pada titik set pengawal suhu badan .[2] Peningkatan pada titik set ini mencetus ton otot dan menggigil. Ketika suhu badan meningkat, terdapat rasa sejuk umum sungguhpun suhu badan meningkat. Sebaik sahaja tahap suhu baru dicapai terdapat rasa panas. Demam merupakan satu tindak imunisasi balas yang cuba menangani jangkitan bacteria atau virus. Demam boleh dicetuskan oleh pelbagai keadaan dari selamat kepada potensi serius. Kecuali demam yang tinggi, rawatan biasanya tidak diperlukan, bagaimanapun, ibuprofen adalah berkesan bagi menurunkan suhu badan. Demam berbeza daripada hiperthermia luar kawal[1], biasanya dirujuk hanya sebagai hiperthermia, dari segi hiperthermia merupakan peningkatan suhu badan melebihi titik set pengawalansuhu badan, akibat penghasilan suhu melampau/ pengawalan suhu ...
Setiap masa vitamin c dalam badan kita musnah, akibat radikal bebas laa, akibat dari asap rokok orang sekeliling laa, sebab stress laa, sebab tak cukup tidur laa dan macam-macam sebab laa vitamin c dalam badan kita hilang ...
Menurut sumber, mangsa dipercayai dari Group Mee Hay SBK dan bukan warganegara Malaysia. Motosikal itu terbabas lalu merempuh penghadang jalan menyebabkan badan mangsa putus dua.Apa yang lebih mengejutkan, walaupuan badan terputus dua, mangsa didapati masih hidup. ...
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BADAN HOWELL-JOLLY Badan ini adalah sisa inti yang mengandung DNA.Ukurannya sekitar 1-2u. dapat ditemukan tunggal atau ganda, letaknya ekstentrik di dekat membran eritrosit. Dapat dijumlai pada: pasca splenektomi thalassemia anemia hemolitik anemia megaloblastik hiposplenia fungsional TITIK-TITIK BASOFIL (BASOPHILIC STIPPLING) Titik basofil ditemukan di dalam eritrosit sebagai titik-titik kecil berwarna biru tua (basofilik),diduga merupakan sisa RNA…
Menggunakan deodoran tidak selamanya menjadi solusi untuk mengatasi masalah bau badan. Berikut ini cara ampuh terbebas bau badan tanpa menggunakan deodoran.
Jumlah kolesterol yang tinggi dan berlebihan di dalam badan boleh menyebabkan masalah kesihatan yang serius terhadap sistem kardiovaskular badan. Darah di dalam badan akan membawa kolesterol yang terdapat di dalam badan ke pelbagai organ dan kelenjar yang memerlukannya. Ia dibawa oleh sejenis pembawa yang dikenali sebagai lipoprotein. Apabila terlalu banyak kolesterol yang melalui saluran darah, kolesterol ini akan mula terbentuk di dinding arteri iaitu pada dinding saluran darah. Pembentukan kolesterol ini dipanggil plak seterusnya memberi kesan kepada sistem kardiovaskular badan. ...
BERAT BADAN 45 KG... siyes, b4 ni nk cecah 40 kg pun susah... sejak dua mnjak org dok kata badan dah berisi, gemuk, saya happy sebab memang misi dan matlamat saya untuk menambah berat badan.. last week timbang berat badan.. and SUNGGUH TAK PERCAYA BERAT BADAN SUDAH 45 KG..! 45 KG tu wey..ingt senang ke nak jadi 45 KG?? sekarang BMI dah jadi normal... first time BMI normal.. sejak dilahirkan, BMI mmg salu xnormal..UNDERWEIGHT! but now saya bangga saya sudah tergolong dalam geng NORMAL! ...
Transfected EC (4-5 × 106 cells/6 ml) were rinsed with DPBS and then were cultured at 37°C for 24 h in complete DMEM containing G418 (600 μg/ml), 2% dialyzed FBS, 2 mMl-glutamine, 20 mM d-glucose, and 0.4 mMl-arginine plusl-[1-14C]arginine. Conditioned media were used for determining nitrite and nitrate (two major stable end products of NO oxidation) as well as urea and amino acids, whereas cells were used for determining intracellular content of amino acids and polyamines, as described below.. Nitrite in culture media was analyzed on the basis of its derivatization with 2,3-diaminonaphthalene to form 2,3-naphthotriazole as described by Misko et al. (17), except that the product was analyzed by HPLC to improve sensitivity and specificity (12). Briefly, 100 μl of 1:3 diluted medium or NaNO2 standards (0-500 pmol/ml; prepared in blank culture medium) were incubated for 10 min at room temperature with 10 μl of 316 μM 2,3-diaminonaphthalene (in 0.62 M HCl), followed by addition of 5 μl of 2.8 ...
Basically, collagen ni adalah protein dalam badan manusia yang berfungsi sebagai menyokong dan melindungi tisu-tisu lembut serta menyambungkannya dengan tulang badan. Collagen juga penting untuk menghasilkan protein bagi membantu pertumbuhan serta mengaktifkan penjanaan semula sel badan baru. Tau tak kawan2 yang kulit kita akan hilang keanjalan semulajadi bila mencapai usia 20-an sebab collagen semakin berkurang dalam badan kita. Bayangkan kalau mak/ibu kita amalkan collagen dri muda mesti kulit mereka kalah kulit anak dara.haaa mau tak jeles.. ...
Haaa... Jelas tak?? Secara ringkasnya, healing crisis cuma satu tempoh yg diambil untuk proses2 membersihkan badan, penyingkiran toksin dan untuk bina semula sel2 badan yg lebih kuat dari sebelum ni. Ibarat tangki yang dah lama tak basuh. Bila basuh, berus, sental... banyakkkk la karat2 yang keluar dari tangki tuuu... Bila karat2 tu semua dah clear, dah bersih... air yang mengalir dari tangki tu pun laju jerrr. Kita nak guna untuk basuh ape2 pun best! Betul tak?? Macam tu jugalah badan kita ni... Healing crisis ni tak sama dengan orang lain sebab ianya bergantung kepada tahap kesihatan kita. Kalau badan ok, sihat... so kurang la healing krisis tu...Yang penting teruskan makan vitamin dan minum banyakkk air masak, insyaAllah ull feel much better ...
MENGIKUT pengamal perubatan alternatif, untuk sihat kita perlu mengambil makanan dalam pecahan 80 peratus makanan beralkali dan 20 peratus makanan berasid untuk mengekalkan kesihatan serta meningkatkan daya ketahanan badan. Namun yang berlaku kini adalah sebaliknya, iaitu 80 peratus makanan bersifat asid dan hanya 20 peratus makanan beralkali. Selain makanan, ramai menyarankan kita minum air beralkali…
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Salam sejahtera Kak Zura ucapkan buat pembaca blog Kak Zura ni. Sihat? Dah makan? Meh nak share tips best nih.. mungkin boleh bantu bagi yang nak berdiet dengan alsdii untuk lebih cepat lagi dapat kesan turun berat.. 5 Tips Kurus Badan Masa Diet SDII Kawal pemakanan Bunyinya memang selalu dan mudah didengar tetapi amat.... ...
i dah malas nak catu2 makan i lagi sbb i dah ada solution baru iaitu dengan pemakaian PREMIUM BEAUTIFUL... lagi best bila pakai set ni, u tak payah nak diet la sbb u boleh makan apa saja u nak (tp jgn l sampai semua benda u nampak, u all balun) bantu membakar kalori dalam badan, klu u all bersenam lagi cepat mmbantu... dan banyak lagi kelebihan & keistimewaannya.... ...
Injek epi ni caranya adalah kita duduk di katil sambil mengerekot/menunduk seakan bulatkan badan. Then doc akan injek tulang belakang kita dan masukkan ubat penahan sakit tu melalui tiub getah yang dilekatkan di belakang kita. Then ubat tu la sebagai bius masa kita bersalin nanti supaya kita takdela rasa sakit sangat masa nak bersalin. Rasanya kita akan kebas dibawah badan so kurangla rasa sakit tu. Doc bius pulak akan kawal berapa banyak ubat yang dia nak lepaskan dalam badan kita mengikut tahap kesakitan yang kita rasa. Contohnya, dia akan tanya sakit tak? Bila kita cakap sakit sangat ni doc, so dia akan slowly lepaskan lebih banyak ubat penahan sakit tu melalui tiub dalam badan kita. ...
PASTI badan yang sakit dan lenguh-lenguh akan kembali segar apabila mendapat urutan oleh tukang urut yang mahir.Proses urutan bukan sahaja membantu membuang ang
Golongan ini adalah golongan yang KURANG MINUM AIR ATAS ALASAN MALAS KE TANDAS. Jika ini berlaku pada anda, better jangan amik supplement kerana pengambilan supplement memerlukan banyak air demi penyerapan yang baik oleh badan manusia. Jika pengambilan biasa bagi kita ialah 2 liter air..keadaan ini hanya sesuai jika kita tidak mengambil apa-apa supplement. Namun bagi pengamal supplement, pengambilan air perlu banyak demi menyahtoksik dari badan serta melancarkan penyerapan nutrien oleh badan. Pengambilan air juga membantu meningkatkan keperluan oksigen oleh tubuh. Badan akan mudah letih kerana kepekatan darah dan jantung memerlukan banyak tenaga untuk mengepam. ...
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MEMBANTU MENGURANGKAN BERAT BADAN - Kajian menunjukkan bahawa seseorang mempunyai berat badan yang berlebihan adalah kerana kekurangan Vitamin D dalam badan. Pengambilan Vitamin D dalam diet harian membantu mengurangkan berat badan ...
0022]The (meth)acryloyl groups in the linear (meth)acryloyl-containing compound of the present invention exist at parts of side chains relative to the molecular chain having the longest coupling length in a single molecule, and it is indispensable from the standpoint of satisfactory hardenability and sensitivity that an average of 3 or more be contained in a single molecule. With respect to the pertinent (meth)acryloyl groups, by selecting the structural units which configure the straight-chain portion, it is possible to easily adjust their concentration in a single molecule, that is, the molecular weight per (meth)acryloyl group. For example, when using residue excluding 2 hydroxyl groups from bisphenol as A in the aforementioned general formula (1) as described below, it is possible to obtain approximately the same concentration as with conventional bifunctional epoxy(meth)acrylate, and to have crosslink density in an appropriate range while having multifunctionality, thereby obtaining ...
y Contoh pergerakan / kemahiran yang tergolong dalam kemahiran terbuka:y -belajar kayuh basikal y -main badminton y -menembak sasaran yang bergerak . y Thelen (2000) dalam Gallahue dan Ozmum (2006) menyatakan kawalan motor muncul daripada interaksi yang berterusan dan rapat antara sistem saraf dan penglihatan,anggota badan dan bahagian badan. y Ini menerangkan bahawa pergerakan antara badan berkait rapat dengan sistem saraf yang membawa maklumat y Kawalan motor oleh saraf akan mengawal pergerakan otototot bagi menghasilkan suatu pergerakan. y Kawalan pergerakan yang mencapai menerusi interaksi semua jenis lakuan motor yang mampu dihasilkan oleh sistem biologi . y Lakuan motor adalah penting dalam setiap permainan yang ingin diceburi oleh kanak-kanak supaya setiap apa aktiviti yang dilakukan tidak mendatangkan masalah kepada pergerakan dan kecederaan. y Kemampuan atau kebolehana biomotor melibatkan kekuatan,kelajuan,daya tahan dan koordinasi (Grantin,1940) y Kemampuan motor dapat membantu ...
Regimen penggunaan kortikosteroid pada SN bermacam-macam, di antaranya prednison 125 mg setiap 2 hari sekali selama 2 bulan kemudian dosis dikurangi bertahap dan dihentikan setelah 1-2 bulan jika relaps, terapi dapat diulangi(17) Regimen lain pada orang dewasa adalah prednison/prednisolon 1-1,5 mg/kg berat badan/hari selama 4 minggu diikuti 1 mg/kg berat badan selang 1 hari selama 4 minggu. Sampai 90% pasien akan remisi bila terapi diteruskan sampai 20-24 minggu(7) namun 50% pasien akan mengalami kekambuhan setelah kortikosteroid dihentikan(7,9). Hopper(19) menggunakan dosis 100 mg per 48 jam. Jika tidak ada kemajuan dalam 2-4 minggu, dosis dinaikkan sampai 200 mg per 48 jam dan dipertahankan sampai proteinuri turun hingga 2 gram atau kurang per 24 jam, atau sampai dianggap terapi ini tidak ada manfaatnya. Pada anak-anak diberikan prednison 60 mg/m2 luas permukaan tubuh atau 2 mg/kg berat badan/hari selama 4 minggu, diikuti 40 mg/m2 luas permukaan tubuh setiap 2 hari selama 4 minggu(7 ...
APAKAH PUNCA KULIT KEDUT DAN KENDUR?. A) faktor usia - apabila usia kita meningkat, paras pelbagai hormon di dalam badan akan berkurangan. Bagi wanita yang telah menopaus, hormon estrogen yang memainkan peranan penting untuk menghasilkan kolagen akan berkurangan menyebabkan kulit hilang keanjalan. Sel sel di dalam badan juga kurang aktif.. B) Graviti - daya tarikan graviti yang menarik semua objek ke bumi mempunyai kesan yang sama terhadap kulit kita menjadikan kulit semakin kendur apabila usia semakin meningkat.. C) Pancaran matahari - sinaran matahari yang kuat boleh menyebabkan kulit cepat kedut dan kendur melalui proses pengoksidaan.. D) Kekurangan air - air juga memainkan peranan yang penting untuk keanjalan kulit. Sekiranya badan mengalami dehidrasi, kulit akan kendur dan kedut.. E) kurang vitamin - kulit memerlukan Vitamin A dan C untuk menghasilkan kolagen. Oleh yang demikian kekurangn Vitamin A dan C juga boleh menyebabkan kulit kendur. F) Tabiat berulang - sekiranya seseorang itu suka ...
Inayah tidak terhad kepada wanita shj. Lelaki juga Boleh Makan Inayah. Begitu juga Bagi pesakit yang Menghadapi Masalah sakit Sendi, Darah Tinggi, Hati dan Jantung. Gastrik juga boleh Makan Inayah. Ibu mengandung & Ibu menyusu Juga digalakkan mencuba Inayah kerana Inayah mengandungi Supplement yang Menyokong wanita mengandung & ibu menyusu. Begitu Juga dengan wanita yang Ingin Berpantang, Inayah Bukan shj Mencantikkan tubuh Badan tetapi, Sihat dan Ramping. Kami pasti Ramai yang menginginkan Bentuk badan Yang cantik dan Sihat terutama Selepas Mengandung. Wanita Yang semakin Meningkat Umur akan mengalami Banyak permasalahan, terutama dari segi pertukaran Hormon dalam Badan. Maka, Inayah Insyaallah Dapat membantu menyelesaikan Masalah-masalah Anda semua ...
12-Jangan percaya pada mitos. Mitos seperti minum air banyak akan meyebabkan peranakan berair atau memakan sayuran kerana menyebabkan angin adalah tidak benar sama sekali. Minum air secukupnya penting kerana selepas 1-3 hari bersalin badan secara semula jadi akan membuang air lebihan yang terkumpul semasa hamil dan ini akan membuatkan badan kekurangan air medadak, menjurus kepada masalah sembelit dan kekurangan susu badan. Kekurangan air juga menyebabkan luka episiotomi sukar sembuh dan masalah sembelit pula akan menyebabkan kesakitan ketara pada luka anda. ...
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44. Addition of mercury(II) electrophiles to [Ru2(C10H8N2)(CO)4(PiPr3)2] and selective insertion versus addition in the reactions of mercury(II) electrophiles with trinuclear Ru2Hg clusters. X-Ray structures of [Ru2Hg(O2CCF3)2(C10H8N2)(CO)4(PiPr3)2] and [Ru2Hg2Cl4(C10H8N2)(CO)4(PiPr3)2] CH2Cl2 (C10H10N2 = 1,8-diaminonaphthalene). (PDF). ...
Lelaki menyukai wanita yg pandai menjaga penampilannya agar sentiasa kelihatan cantik, bersih, kemas dan menarik. Penampilan yg baik menunjukkan wanita tersebut menghargai dirinya.Dia akan murah senyuman,pandai merawat tubuhnya, meningkatkan kualiti hidupnya dan memberi yg terbaik kepada dirinya.Dia suka dan bersyukur dengan dirinya dan secara tidak langsung memancarkan pesona yg menyebabkan lelaki juga menyukainya. Apabila sudah berumahtangga, wanita tersebut terus menjaga penampilan dirinya dan kesihatan tubuh badan walau sudah beranak-pinak. Siapa yg tidak suka isteri yg masih kelihatan cantik dan ramping walau dah punya anak 3?? 6.Pandai berbicara Lelaki tertarik dgn wanita yg pandai berkomunikasi dan boleh diajak berbual. Walau topik perbualan yg disukai lelaki berbeza dgn topik kegemaran wanita,wanita tersebut dapat mengimbanginya. Dia bukan sekadar teman berbual yg pasif, tetapi dapat memberi respon dan pendapat yg baik.Dia juga tahu menjadi pendengar yg baik, serta mengalihkan topik yg ...
Ketidakseimbangan pH badan ke arah keasidan dalam jangka panjang akan mengakibatkan seseorang mengalami penyakit kronik seperti kencing manis, tekanan darah tinggi, kolesterol tinggi, kanser, gout, sakit buah pinggang dan lain-lain. Oleh itu keadaan yang berlawanan perlu dilakukan untuk mengimbangi tahap keasidan. OXY-PI DIonik mampu menjalankan tugas tersebut kerana ia terdiri daripada kelompok molekul air kecil dan bersifat alkali, berupaya menguraikan sisa-sisa asid yang terkumpul dan memudahkan proses pembuangan melalui sistem pencernaan, perpeluhan dan pernafasan. Selain dari itu, manfaat dan kebaikan yang diperolehi daripada amalan meminum OXY-PI DIonik adalah ia dapat membantu dalam meningkatkan imunisasi badan dan melenyapkan radikal bebas melalui sifat anti-oksidan yang dimiliki, serta ...
Selain itu, LH merangsang folikel yang telah kosong untuk berubah menjadi badan kuning (Corpus Luteum). Badan kuning menghasilkan hormon progesteron yang berfungsi mempertebal lapisan endometrium yang kaya dengan pembuluh darah untuk mempersiapkan datangnya embrio. Periode ini disebut fase luteal, selain itu progesteron juga berfungsi menghambat pembentukan FSH dan LH, akibatnya korpus luteum mengecil dan menghilang, pembentukan progesteron berhenti sehingga pemberian nutrisi kepada endometriam terhenti, endometrium menjadi mengering dan selanjutnya akan terkelupas dan terjadilah perdarahan (menstruasi) pada hari ke-28. Fase ini disebut fase perdarahan atau fase menstruasi. Oleh karena tidak ada progesteron, maka FSH mulai terbentuk lagi dan terjadilan proses oogenesis kembali. ...
Dengan Nama Allah Yang Maha Pemurah Lagi Maha Pengasih... Ya Allah, sekiranya rezeki kami berada di langit, maka turunkanlah ia; jika ia ada di bumi, keluarkanlah ia; dan jika ia ada di dalam lautan, munculkanlah ia. Sekiranya rezeki kami ada di tempat yang jauh, dekatkanlah ia; jika ia sedikit, banyakkanlah ia; dan jika caranya sukar untuk sampai kepada kami, mudahkanlah ia, serta pindahkanlah rezeki tersebut kepada kami dengan Kemuliaan, Kepemurahan dan KebaikkanMu, dengan RahmatMu, Wahai Yang Maha Pengasihi diantara Yang Pengasih." ...
Dengan Nama Allah Yang Maha Pemurah Lagi Maha Pengasih... Ya Allah, sekiranya rezeki kami berada di langit, maka turunkanlah ia; jika ia ada di bumi, keluarkanlah ia; dan jika ia ada di dalam lautan, munculkanlah ia. Sekiranya rezeki kami ada di tempat yang jauh, dekatkanlah ia; jika ia sedikit, banyakkanlah ia; dan jika caranya sukar untuk sampai kepada kami, mudahkanlah ia, serta pindahkanlah rezeki tersebut kepada kami dengan Kemuliaan, Kepemurahan dan KebaikkanMu, dengan RahmatMu, Wahai Yang Maha Pengasihi diantara Yang Pengasih." ...
Asid Lemak-Omega-3 merupakan asid lemak yang penting yang tidak dapat di hasilkan oleh badan kita. Oleh itu, kita perlu mengambilnya dari makanan. Omega-3 dari asas tumbuhan tidak boleh ditukarkan kepada EPA dan DHA secara berkesan oleh badan. Omega-3 membantu rembesan prostaglandin dengan lebih berkesan untuk menghalang prostetomegaly dan membuang air kecil yang timbul daripada punca andropos. Ia juga boleh mengimbangi perubahan dalam kepekatan hormon wanita yang menyebabkan PMS, bagi kulit licin dan kemerah-merahan ...
Penyempitan berlaku di saluran darah akibat pengumpulan lemak. Jantung merupakan organ yang mengepam darah mengandungi oksigen dan nutrien seraya disebarkan ke seluruh tubuh badan bagi membolehkan sel-sel dalam badan berfungsi dengan sempurna. Jika otot jantung tidak dapat menerima oksigen dan nutrien yang mencukupi, radangan akan berlaku dan memberi kesan kepada penyakit jantung. ...
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Seseorang yang menghadapi masalah insomnia akan sukar tidur.Ini pasti akan menggangu rutin harian anda dipejabat.Badan jadi lesu dan malas serta kurang aktif.Bekam darah boleh dilakukan untuk atasi masalah anda.Dengan berbekam peredaran darah lebih lancar dan badan makin cergas.. Hubungi. PN AINI 019-2608092(BANGI)@. MOHD FAZERIN 017-5465185(BANGI)@. CIK FINA 013-3159752(KL)@. PN SITI 019-7864957(JB)@. PN SUZIAH 014-3533691(SABAH). ...
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2 (7213): 1157-63. doi:10.1016/s0140-6736(61)90839-x. PMID 13888312. Boyland E, Dukes CE, Grover PL, Mitchley BC (1962). "The ... 2 (6): 299-309. PMC 1940220 . PMID 18865338. Dukes CE, Morgan CN (1948). "Double carcinoma of the rectum and recto-sigmoid ... 2 (2): 95-8. doi:10.1136/jcp.2.2.95. PMC 1023239 . PMID 16810849. Dukes CE, Masina F (1949). "Classification of epithelial ... 2 (4848): 1262-4. doi:10.1136/bmj.2.4848.1262. PMC 2030259 . PMID 13106406. Dukes CE, Cooke WT, Butler EC (1953). "Discussion ...
1-Naphthylamine is reacted with cyanogen bromide to give 2. Treatment of this intermediate with 3-ethyl-N-methylaniline leads ... 37 (2): 260. doi:10.1021/jm00028a009. PMID 8295213. E. Weber, J. F. W. Keana, WO 9112797 ; eidem, U.S. Patent 5,262,568 (1991, ... 2004 Mar;4(2):131-6. PMID 15032709 Staff, Boston Business Journal. May 7, 1998. CNSI appoints new president, CEO Staff, ICIS. ... 1994 Jan 21;37(2):260-7. PMID 8295213 Muir KW, Grosset DG, Gamzu E, Lees KR. Pharmacological effects of the non-competitive ...
... (2-amino-2'-hydroxy-1,1'-binaphthyl) is an organic molecule used for asymmetric catalysis. NOBIN is related to BINOL and ... NOBIN is prepared by oxidative cross coupling of 2-naphthol and 2-naphthylamine. The oxidative source is metal ions in solution ...
... , a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of ... N,N-Bis(2-Chloroethyl)-2-Naphthylamine (Chlornaphazine), International Agency for Research on Cancer. ... Videbaek, A.; Kaae, S. (1954). "2-Naphthylbis(chloroethyl)amine in the treatment of malignant diseases, particularly Hodgkin's ...
However, it is a weaker bidentate ligand as the nitrogen atom in the naphthylamine group is weakly coordinating due to the ... This compound can be prepared by the reaction of 1-naphthylamine with 2-chloroethanamine. It is commercially available as the ... N-(1-Naphthyl)ethylenediamine undergoes most reactions typical to naphthylamine and primary amines such as diazotation. Similar ...
antioxidant: N-phenyl-2-naphthylamine. 0.5%. 0.5%. 0.5% pigment. 0.5% Sudan IV (reddish brown to red). 0.5% Sudan I (red-orange ... Explosia's brief historical document states it was 1964,[2] but most other credible sources state it was in 1966. Most of these ... First, ethylene glycol dinitrate was used, later switched to 2,3-dimethyl-2,3-dinitrobutane (DMDNB) or p-mononitrotoluene (1- ... 2] Batches of Semtex made before 1990, however, are untagged, though it is not known whether there are still major stocks of ...
Pyrrolidonyl-beta-naphthylamide P-Dimethylaminocinnamaldehyde Pyroglutamic acid 2-Naphthylamine Panosian KJ, Edberg SC (March ...
3.0.CO;2-Q. PMID 10931463. Osch, Frits H. M. van; Jochems, Sylvia H. J.; Schooten, Frederik-Jan van; Bryan, Richard T.; Zeegers ... 2-Naphthylamine, which is found in cigarette smoke, has also been shown to increase bladder cancer risk. Occupations at risk ... BCG immunotherapy is effective in up to 2/3 of the cases at this stage, and in randomized trials has been shown to be superior ... 48 (2): 202-5; discussion 205-6. doi:10.1016/j.eururo.2005.04.006. PMID 15939524. Grossman HB, Natale RB, Tangen CM, et al. ( ...
2-NA) was involved in human bladder tumorigenesis. With Adolph Strümpell (1853-1925), the eponymous "Strümpell-Leichtenstern ... In 1898 he suspected that the compound 2-naphthylamine ( ...
In the presence of bacteria with pyrrolidonyl peptidase, it is broken down to pyroglutamic acid and 2-naphthylamine. To detect ...
Sudan Black is formed by coupling of diazotized 4-phenylazo-1-naphthylamine with 2,3-dihydro-2,2-dimethyl-1H-perimidine. ... Therefore the main product expected was 2,3-dihydro-2,2dimethyl-6-[(4-phenylazo-1-naphthalenyl)-azo]-1H-perimidine. However the ... 3-dihydro-2,2dimethyl-4-[(4-phenylazo-1-naphthalenyl)-azo]-1H-perimidine. "Histochemistry. 1977 Dec 7;54(3):237-50. Sudan Black ...
... specifically 2-Naphthylamine). The only supplier in the United States, the William J. Stange Company, subsequently stopped ...
2,2'-Bisindoles can be bridged to a seven-membered ring structure by 3-dimethylaminocrolein and oxalyl chloride via the ... The amidine formed with 2-naphthylamine and the dimethyl sulfate adduct can be cyclized with sodium methoxide to give benzo[f] ... The use of 3-dimethylaminoacrolein for the synthesis of 2-chloronicotinic acid (2-CNA) is of industrial interest as an ... The resulting esters of 2-chloropyridine carboxylic acid can be hydrolyzed smoothly to 2-chloronicotinic acid. It reacts weakly ...
ISBN 0-471-60180-2. Shine, H. J.; Zmuda, H.; Park, K. H.; Kwart, H.; Horgan, A. G.; Collins, C.; Maxwell, B. E. (1981). " ... As with some other aromatic amines such as 2-naphthylamine, benzidine has been significantly withdrawn from use in most ... First, the nitrobenzene is converted to 1,2-diphenylhydrazine, usually using iron powder as the reducing agent. Treatment of ... These derivatives include, in order of scale, the following: 3,3'-Dichlorobenzidine o-tolidine, 2,2'-dimethyl-4,4'-benzidine o- ...
4-tetrahydro-1-naphthylamine) CP-39,332 (N-methyl-4-phenyl-1,2,3,4-tetrahydro-2-naphthylamine) Cyproheptadine [4-(5H-dibenz-[a, ... 4-Tetrahydro-1-Naphthylamine, a New Uptake Inhibitor with Selectivity for Serotonin" (PDF). The Journal of Pharmacology and ... Koe, BK; Weissman, A; Welch, WM; Browne, RG (September 1983). "Sertraline, 1S,4S-N-Methyl-4-(3,4-Dichlorophenyl)-1,2,3, ... 2] doi:10.1021/ol0257934 Certain aromatic substitutients have a potentiating effect (e.g., p-Br), whereas others negate the ...
2-Amino-1,2-dihydronapthalene (2-ADN), also known as 2-aminodilin (2-AD), is a stimulant drug. It is a rigid analogue of ... 2-Aminoindane 2-Aminotetralin 2-Naphthylamine Hathaway BA, Nichols DE, Nichols MB, Yim GK (May 1982). "A new, potent, ... It is closely related to 2-aminotetralin (2-amino-1,2,3,4-tetrahydronaphthalene), which also substitutes for amphetamine, and ... 2-dihydronaphthalene". Journal of Medicinal Chemistry. 25 (5): 535-8. doi:10.1021/jm00347a011. PMID 6123601. ...
Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N- ... 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p- ...
November 2, 2009 ‐‐ IARC has updated the cancer assessments of several personal habits and household exposures that cause ... 2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... 2-chloroaniline) (MOCA) MOPP and other combined chemotherapy including alkylating agents Mustard gas (Sulfur mustard) 2- ... Naphthylamine Neutron radiation Nickel compounds2 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) N-Nitrosonornicotine ...
Supply is prohibited, during the course of work or for use at work, of (reg.4(3), (4)/ Sch.2, item.11): Any of the substances ... Use of the following substances is prohibited for the purposes specified (reg.4(1)/ Sch.2): The following are excluded from the ... The assessment must include consideration of any information provided by the supplier of a substance (CHIPS) (reg.6(2)(b)) and ... ISBN 0-7545-3318-2. Health and Safety Executive (2003). COSHH essentials: Easy steps to control chemicals. Control of ...
This might take only 1-2 minutes. Then the sample is thoroughly rinsed in water (for one to two hours). Afterwards, the stained ... Alternatively, the product of an acid-catalyzed condensation of 4-nitroso-N,N-dialkylaniline with 2-naphthol (a salt of 9-( ... 2.0.CO;2. PMID 11202363. Kanitz, Andreas; Hartmann, Horst (1999). "Preparation and Characterization of Bridged Naphthoxazinium ... Nile Blue and related naphthoxazinium dyes can be prepared by acid-catalyzed condensation of either 5-(dialkylamino)-2- ...
1-naphthylamine MeSH D04.615.638.845.800 --- sertraline MeSH D04.615.638.850 --- 2-naphthylamine MeSH D04.615.638.870 --- 1- ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 --- levobunolol MeSH D04.615.638.960.585 --- mibefradil MeSH ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 --- fusidic acid MeSH D04.808.247.808.607 --- lanosterol MeSH D04.808.247.808. ... t-2 toxin MeSH D04.345.891.900 --- trichodermin MeSH D04.615.117.050 --- dithranol (anthralin) MeSH D04.615.117.159 --- ...
2, Winter 1999, at 95. Loeb (1999) Peterson, M (2007). "The precautionary principle should not be used as a basis for decision- ... 78 (2): 71-8. doi:10.1006/enrs.1997.3808. PMID 9719610. Jamie Lincoln Kitman (2000-03-20). "The Secret History of Lead". The ... 78 (2): 79-85. doi:10.1006/enrs.1997.3807. PMID 9719611. Kehoe RA (1953). "Experimental Studies on the Inhalation of Lead by ... ISBN 978-0-520-27325-2. Zhang, Sarah. "Leaded Fuel Is a Thing of the Past-Unless You Fly a Private Plane". Mother Jones. Some ...
Naphthalene Naphthol 1-Naphthylamine 1,8-Bis(dimethylamino)naphthalene "NIOSH Pocket Guide to Chemical Hazards #0442". National ... When reduced by sodium in boiling amyl alcohol solution, it forms tetrahydro-3-naphthylamine, which exhibits the properties of ... 2-Naphthylamine is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. It also can ... 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. It is activated ...
Anilines and naphthylamines form more stable diazonium salts, which can be isolated in the crystalline form.[14] Diazonium ... 2. R. 1. ,. :. ⏟. a. m. i. n. e. +. R. 3. −. C. O. ‖. −. OH. ⏟. carboxylic acid. −. ,. H. −. N. +. ,. R. 2. R. 1. ,. −. H. +. R ... 2. R. 1. ,. −. C. O. ‖. −. R. 3. ⏟. a. m. i. d. e. +. H. 2. O. ⏟. w. a. t. e. r. {\displaystyle {\underbrace {\ce {H-\!\!{\ ... 2. +. HNO. 2. +. HX. ⟶. AN. +. 2. X. −. +. 2. H. 2. O. {\displaystyle {\ce {ANH2 + HNO2 + HX -, AN + 2X^- + 2 H2O}}}. ...
... but these effects are now attributed to naphthylamines, not anilines.[6] ... 2 C6H5NH2 + CH2O → CH2(C6H4NH2)2 + H2O. The resulting diamine is the precursor to 4,4'-MDI and related diisocyanates. ... C6H5NH2 + 2 CH3OH → C6H5N(CH3)2 + 2H2O. N-Methylaniline and dimethylaniline are colorless liquids with boiling points of 193- ... Aniline is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is ...
Anilines and naphthylamines form more stable diazonium salts, which can be isolated in the crystalline form.[14] Diazonium ... 2. R. 1. ,. :. ⏟. a. m. i. n. e. +. R. 3. −. C. O. ‖. −. OH. ⏟. carboxylic acid. −. ,. H. −. N. +. ,. R. 2. R. 1. ,. −. H. +. R ... 2. R. 1. ,. −. C. O. ‖. −. R. 3. ⏟. a. m. i. d. e. +. H. 2. O. ⏟. w. a. t. e. r. {\displaystyle {\underbrace {\ce {H-\!\!{\ ... 2. +. HNO. 2. +. HX. ⟶. AN. +. 2. X. −. +. 2. H. 2. O. {\displaystyle {\ce {ANH2 + HNO2 + HX -, AN + 2X^- + 2 H2O}}}. ...
Naphthalene Naphthol 1-Naphthylamine 1,8-Bis(dimethylamino)naphthalene "NIOSH Pocket Guide to Chemical Hazards #0442". National ... When reduced by sodium in boiling amyl alcohol solution, it forms tetrahydro-3-naphthylamine, which exhibits the properties of ... 2-Naphthylamine is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. It also can ... 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. It is activated ...
Testing Status of N-Phenyl-2-naphthylamine 10586-X. CASRN: 135-88-6. Formula: C16-H13-N. Synonyms/Common Names. *N-Phenyl-2- ... Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies ... Citation: Metabolism of N-phenyl-2-naphthylamine (PNA) after Feeding to Fischer 344 Rats. October 15, 1986 ...
Phenyl(b-naphthyl)amine *Phenyl-b-naphthylamine *N-Phenyl-b-naphthylamine *Stabilizator AR Last updated: 11 March 1998 See Also ... 7. Wang, H., Wang, D. & Dzeng, R. (1984) Carcinogenicity of N-phenyl-1-naphthylamine and N-phenyl-2-naphthylamine in mice. ... naphthylamine in rats after intragastric administration. Cancer Lett., 16, 203-206 4. Green, U., Holste, J. & Spikermann, A.R ... N-Phenyl-2-naphthylamine is not classifiable as to its carcinogenicity to humans (Group 3). For definition of the italicized ...
N-PHENYL-2-NAPHTHYLAMINE. VOL.: 16 (1978) (p. 325) 5. Summary of Data Reported and Evaluation1. 5.1 Animal data. N-Phenyl-2- ... naphthylamine has been tested in mice by oral and single subcutaneous administration and in a small number of dogs by oral ... In one study, in one factory, of men with known exposure to N-phenyl-2-naphthylamine in rubber processing under controlled ... In the latter study, exposure was mixed but probably included exposure to N-phenyl-2-naphthylamine for many workers. These ...
What is 2-naphthylamine? Meaning of 2-naphthylamine medical term. What does 2-naphthylamine mean? ... Looking for online definition of 2-naphthylamine in the Medical Dictionary? 2-naphthylamine explanation free. ... 2-naphthylamine. Also found in: Wikipedia. 2-naphthylamine. an industrial chemical identified as a urinary bladder carcinogen. ... Nitrosamine, 2-naphthylamine, and 4-aminobiphenyl are possible carcinogenic agents found in cigarette smoke3.. RISK FACTORS FOR ...
4-tetrahydro-1-naphthylamine. Regulatory process names 1 CAS names 1 IUPAC names 2 Other identifiers 2 ...
N-ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine. ↓Other names: Regulatory process names [2] IUPAC names [2] ... N-Ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine * N-ethyl-1-[(E)-2-{4-[(E)-2-phenyldiazen-1-yl]phenyl}diazen-1-yl]naphthalen ...
Find quality suppliers and manufacturers of 2-Naphthylamine-5,7-disulfonic acidfor price inquiry.where to buy 2-Naphthylamine-5 ... 7-disulfonic acid.Also offer free database of 2-Naphthylamine-5,7-disulfonic acid including MSDS sheet(poisoning, toxicity, ... naphthylamine -1,5,7 - 3-sulfonic acid in water at 110-120 °C 4h, cooling and filtering, washing in sodium sulfate solution, ... Naphthylamine-5,7-disulfonic acid;6-AMINO-NAPHTHALENE-1,3-DISULFONIC ACID;Naphthalene-1,3-disulfonic acid, 6-amino-;6-Amino-1, ...
... α-naphthylamine (CAS 2933-59-7) Market Research Report 2018 aims at providing comprehensive data on n-(2-hydroxyethyl)-α- ... α-naphthylamine prices in other regions. 7. N-(2-HYDROXYETHYL)-α-NAPHTHYLAMINE END-USE SECTOR 7.1. N-(2-hydroxyethyl)-α- ... α-NAPHTHYLAMINE PATENTS. Abstract. Description. Summary of the invention. Detailed description of the invention. 5. N-(2- ... α-naphthylamine consumers globally. - Europe. - Asia. - North America. - Other regions. *Please note that N-(2-Hydroxyethyl)-α- ...
1-nitro-2-naphthylamine ; physical and chemical property of 606-57-5, 1-nitro-2-naphthylamine is provided by ChemNet.com ... CAS No: 606-57-5, Chemical Name: 1-nitro-2-naphthylamine. Home , Products , Suppliers , Offer to Buy , Offer to Sell , Chemical ... 1-nitro-2-naphthylamine. Synoniemen. 2-Naphthylamine, 1-nitro-; 1-Nitro-2-naphthylamine; 2-Amino-1-nitronaphthalene; 4-12-00- ... ChemNet , CAS , 606-57-5 1-nitro-2-naphthylamine. 606-57-5 1-nitro-2-naphthylamine. Naam product. ...
Naphthylamine and 2-Nitronaphtalene metabolism Metabolism and binding studies with 2-Naphthylamine and many other arylamines ... 2-Naphthylamine and 2-Hydroxyamino-naphthalene conjugate with UDP-D-glucuronic acid and form respectively 2-Naphthylamine-N- ... In addition, both 2-Hydroxyamino-naphthalene and 2-Amino-1-Naphthol form sulphate conjugates N-Hydroxy-2-naphthyl-sulfamic acid ... 2-Nitronaphthalene is oxidized to 2-Nitronaphthalene-5,6-oxide and 2-Nitronaphthalene-7,8-oxide by following enzymes: ...
68-dichloro-2-methyl-benzoebenzothiophene-4-carboxylic-acid-albumin.html. *4-5-methyl-2-phenyl-phenoxyphthalonitrile-albumin. ... 2-methylspiro56-dihydrodibenzo12-a12-ecycloheptene-111-isoindoline-albumin.html. *pyrrol21-aisoquinoline-123-tricarboxylic-acid ... Prediction result: Albumin ligand (prediction accuracy: 92.1%), binding site 2 (prediction accuracy: 80.0%). Submit ... Prediction : 1-o-tolylazo-2-naphthylamine - albumin. Your feedback has been submited, thank you! ...
N-Phenyl-1-naphthylamine(90-30-2) Density MSDS Formula Use,If You also need to N-Phenyl-1-naphthylamine(90-30-2) Other ... ChemicalBook provide Chemical industry users with N-Phenyl-1-naphthylamine(90-30-2) Boiling point Melting point, ... N-Phenyl-1-naphthylamine Basic information Product Name:. N-Phenyl-1-naphthylamine. Synonyms:. *N-Phenyl-1-naphthylaMine ... N-Phenyl-1-naphthylamine is probably combustible.. Contact allergens. Phenyl-alpha-naphthylamine is contained in some rubbers ...
2-naphthylamine 91-59-8 Precursor and Downstream products, 2-naphthylamine Precursor products, 2-naphthylamine Downstream ... Current Page: Home › Chemical Dictionary › 91-59-8 › 2-naphthylamine 91-59-8 Precursor and Products ... 86-60-2 131-27-1 81-05-0 117-62-4 540-69-2 60-80-0 7664-41-7 91-20-3 64-19-7 7664-93-9 32316-92-0 7647-01-0 64-17-5 580-13-2 71 ...
2-naphthylamine 91-59-8 MSDS report, 2-naphthylamine MSDS safety technical specifications search, 2-naphthylamine safety ... ADR/RID: beta-NAPHTHYLAMINE, SOLID. IMDG: beta-NAPHTHYLAMINE, SOLID. IATA: beta-Naphthylamine, solid Transport hazard class(es) ... β-Naphthylamine. Synonyms. 2-Aminonaphthalene. Formula : C10H9N Molecular Weight : 143,19 g/mol Component Concentration 2- ... Naphthylamine. CAS-No. 91-59-8 - EC-No. 202-080-4 Index-No. 612-022-00-3 Section 4. FIRST AID MEASURES. Description of first ...
2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride - Similar structures search, synonyms, formulas, resource links, and ... 1S/C20H25N.ClH/c1-19(2)15-20(21-3,13-16-9-5-4-6-10-16)14-17-11-7-8-12-18(17)19;/h4-12,21H,13-15H2,1-3H3;1H. Download. ... Substance Name: 2-Naphthylamine, 1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride. RN: 31209-75-3. InChIKey: ...
2 5 smoker-yr of. exposure during. childhood. 2.07 (CI, 1.16-3.68). Matched for age, sex,. and county of. residence; relative. ... 1986; Blot and Fraumeni 1986] (Table 2).. Hole et al. [1989]. Hole et al. [1989] updated an earlier cohort study [Gillis et al ... 1989], only 2 deaths from lung cancer occurred in the unexposed group and 7 in the exposed group, compared with 147 deaths from ... Each patient was matched by age, hospital, and admission date to 2 controls of the same sex who did not have lung cancer (for ...
N-Phenyl-1-Naphthylamine CAS 90-30-2 FOB Price: US $ 5100-5300 / Ton. Min. Order: 1 Ton ...
2-Chloro-4,6-diphenyl-1,3,5-triazine TCI-C2703 , 3842-55-5 , C15H10ClN3 , TCI America 2-Chloro-4,6-diphenyl-1,3,5-triazine ... 2,4,6-Triphenyl-1,3,5-triazine TCI-T2785 , 493-77-6 , C21H15N3 , TCI America 2,4,6-Triphenyl-1,3,5-triazine ... 2-Chlorobenzimidazole TCI-C1719 , 4857-06-1 , C7H5N2Cl , TCI America 2-Chlorobenzimidazole ... N-Benzyl-2-naphthylamine TCI-B3088 , 13672-18-9 , C17H15N , TCI America N-Benzyl-2-naphthylamine ...
having diabetes - bladder cancer is thought to be linked to certain treatments for type 2 diabetes ...
Buy 2-Aminonaphthalene (ring-D7,98%) - CAS Number 93951-94-1 from LGC Standards. Login or Register to enable purchase of any ... 1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin approx. 25 ng/mL in Nonane. 0.2 mL. CIL-JR-D49-25. In den Warenkorb ... 1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin approx. 25 ng/mL in Nonane. 0.2 mL. CIL-JR-D47-25. In den Warenkorb ... 1,2,3,4,6,7,9-Heptachlorodibenzo-p-dioxin approx. 25 ng/mL in Nonane. 0.2 mL. CIL-JR-D48-25. In den Warenkorb ...
Antioxidants for Hot Melt Adhesive Powder N-phenyl-2-naphthylamine PBN ANTIOXIDANT D ... Pbn Antioxidant D Supplier , Antioxidant D Supplier , N-phenyl-2-naphthylamine Antioxidant D Supplier ...
InChI=1S/C12H13N/c1-13(2)12-8-7-10-5-3-4-6-11(10)9-12/h3-9H,1-2H3 ... N,N-Dimethyl-«beta»-naphthylamine. *Formula: C12H13N. * ...
N-Phenyl-1-naphthylamine. 10 mg. LGCFOR2549.00. Add to basket N-Phenyl-2-naphthylamine. 10 mg. LGCFOR2550.00. Add to basket ... 2-Phenylethylamine Hydrochloride (Phenethylamine Hydrochloride, PEA HCl). 10 mg. LGCFOR1275.47. Add to basket ... N-Phenyl-1-(2-phenylethyl)piperidin-4-amine. 10 mg. LGCFOR0528.04. Add to basket ... 2-Phenylethylamine Hydrochloride (Phenethylamine Hydrochloride, PEA HCl) 1.0 mg/ml in Methanol (as free base). 1 mL. ...
  • The chemicals include benzene and 2-naphthylamine , known human carcinogens, cadmium and n-nitrosodiethanolamine, which is associated with cancer in humans, and polonium-210, an element that emits alpha radiation. (thefreedictionary.com)
  • Some of the major conceptual advances in chemical carcinogenesis made during the past several years have been (1) the discovery of the enzymatic activation of procarcinogens to reactive ultimate carcinogens, (2) the characterization of interactions of the active metabolites of many carcinogens with a variety of tissue nucleophiles including DNA, RNA, and protein, and (3)the development of model systems for a sequential analysis of the initiation phase of carcinogenesis. (springer.com)
  • After N-oxidation of aromatic amines such as 4-aminobiphenyl or 2-naphthylamine by CYP1A2 in the liver, O-acetylation of the resulting hydroxylamine by NAT2 can produce unstable acetoxy esters that decompose to form highly electrophilic aryl nitrenium ion species. (thefreedictionary.com)
  • 2) Many of them, particularly carcinogenic aromatic amines (AA) like 2-naphthylamine and 4-aminobiphenyl and polycyclic aromatic hydrocarbons (PAHs) are combustion products not detected in vapours of e-cigarettes and only in very small amounts in aerosol of tobacco heating systems (THS). (bmj.com)
  • Naphthylamine is an aromatic amine which can be obtained from nitronaphthalene (with iron and hydrochloric acid) or naphthol with sodium acetate, ammonium chloride. (chemicalland21.com)
  • More speci?cally, it relates to (1) a process for the preparation of quaterm'zed heterocyclic azo dyes, (2) to a process for the deoxygenation of mon azine oxides by the action of certain metals in an inert 15 solvent, (3) to a process for the deoxygenation of mon-' azine oxides with phosphorous trichloride in halogenated aromatic solvents and (4) to certain new azo derivatives of monazine oxides. (docme.ru)
  • 2-Hydroxyamino-naphthalene is formed in the reaction of N-oxidation catalyzed by unspecific monooxygenase [ 2 ]. (bio-rad.com)
  • 2-Hydroxyamino-naphthalene is formed by reduction of 2-Nitrosonaphthalene in the reaction of catalyzed by unknown oxidoreductase [ 9 ]. (bio-rad.com)
  • First, ethylene glycol dinitrate was used, later switched to 2,3-dimethyl-2,3-dinitrobutane (DMDNB) or p -mononitrotoluene (1-methyl-4- nitrobenzene ), which is used currently. (wikipedia.org)
  • In another experiment, two rare kidney tumours were seen in female mice [ref: 2]. (inchem.org)
  • November 2, 2009 ‐‐ IARC has updated the cancer assessments of several personal habits and household exposures that cause cancer, including tobacco, areca nut, alcohol, and household coal smoke. (wikipedia.org)
  • 2) The Principal Regulations, the Regulations of 2003 and these Regulations may be cited together as the European Communities (Dangerous Substances and Preparations) (Marketing and Use) Regulations 2003 to 2004. (irishstatutebook.ie)
  • For example, benzepyrene, 2-naphthylamine, and 4-aminobiphenyl are metabolized by the body's P450 system to form reactive substances that can chemically interact with DNA nucleotides and cause mutations ( 9 , 10 ). (pnas.org)
  • 2-naphthylamine is also a chemical compound that had uses in dyeing, but today it is replaced with other less toxic substances. (mysite2.com)
  • Hydrogen-bonding-induced electron transfer from triplet N-N-dialkyl-l-naphthylamines to benzophenone via triplet exciplex' J.Phys.Chem.100・2. (nii.ac.jp)
  • O 3 -activated 1-NA was stable for at least 4 h and could damage cellular DNA at 4° C. During ozonization, hydroperoxides were formed at levels equivalent to between 2 and 20 μ M of hydrogen peroxide and were eliminated by treatment with catalase. (ovid.com)
  • 1. Protect employees from the health hazards presented by hazardous chemicals used in that particular work place and 2. (vims.edu)
  • The online version of this article ( https://doi.org/10.1007/s11270-019-4112-2 ) contains supplementary material, which is available to authorized users. (springer.com)