1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.2-Naphthylamine: A naphthalene derivative with carcinogenic action.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.DiethylaminesDimethylaminesChemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hydroxylamines: Organic compounds that contain the (-NH2OH) radical.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Aminobiphenyl Compounds: Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.Benzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Sulfonic Acids: Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Chromatography, Paper: An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Phenoxypropanolamines: Compounds based on a propanolamine attached via an OXYGEN atom to a phenoxy ring. The side chain is one carbon longer than PHENYLETHYLAMINES.Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Occupational Diseases: Diseases caused by factors involved in one's employment.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Hydroxyethyl Starch Derivatives: Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Software: Sequential operating programs and data which instruct the functioning of a digital computer.One-Carbon Group Transferases: A subclass of transferases that transfer chemical groups containing a single carbon. These include the METHYLTRANSFERASES, the HYDROXYMETHYL AND FORMYL TRANSFERASES, the CARBOXYL AND CARBAMOYL TRANSFERASES, and the AMIDINOTRANSFERASES. EC 2.1.Receptors, Interleukin-8: Cell surface receptors that are specific for INTERLEUKIN-8. Two specific receptor subtypes (type A and B) have been found and bind IL-8 with high affinity.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Musculoskeletal Diseases: Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.Great BritainRisk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Halogens: A family of nonmetallic, generally electronegative, elements that form group 17 (formerly group VIIa) of the periodic table.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.EthaneHydrocarbons, HalogenatedHydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)PropaneAlkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Czechoslovakia: Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.Libya: A country in northern Africa, bordering the Mediterranean Sea, between Egypt, Tunisia, and Algeria, having southern border with Chad, Niger, and Sudan. Its capital is Tripoli.Czech Republic: Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.Explosive Agents: Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)VietnamTrinitrotoluene: A 2,4,6-trinitrotoluene, which is an explosive chemical that can cause skin irritation and other toxic consequences.
Fluorescence studies of the carboxyl-terminal domain of smooth muscle calponin effects of F-actin and salts. (1/241)
The fluorescence parameters of the environment-sensitive acrylodan, selectively attached to Cys273 in the C-terminal domain of smooth muscle calponin, were studied in the presence of F-actin and using varying salt concentrations. The formation of the F-actin acrylodan labeled calponin complex at 75 mm NaCl resulted in a 21-nm blue shift of the maximum emission wavelength from 496 nm to 474 nm and a twofold increase of the fluorescent quantum yield at 460 nm. These spectral changes were observed at the low ionic strengths (< 110 mm) where the calponin : F-actin stoichiometry is 1 : 1 as well as at the high ionic strengths (> 110 mm) where the binding stoichiometry is a 1 : 2 ratio of calponin : actin monomers. On the basis of previous three-dimensional reconstruction and chemical crosslinking of the F-actin-calponin complex, the actin effect is shown to derive from the low ionic strength interaction of calponin with the bottom of subdomain-1 of an upper actin monomer in F-actin and not from its further association with the subdomain-1 of the adjacent lower monomer which occurs at the high ionic strength. Remarkably, the F-actin-dependent fluorescence change of acrylodan is qualitatively but not quantitatively similar to that earlier reported for the complexes of calponin and Ca2+-calmodulin or Ca2+-caltropin. As the three calponin ligands bind to the same segment of the protein, encompassing residues 145-182, the acrylodan can be considered as a sensitive probe of the functioning of this critical region. A distance of 29 A was measured by fluorescence resonance energy transfer between Cys273 of calponin and Cys374 of actin in the 1 : 1 F-actin-calponin complex suggesting that the F-actin effect was allosteric reflecting a global conformational change in the C-terminal domain of calponin. (+info)Cysteine-scanning mutagenesis of an eukaryotic pore-forming toxin from sea anemone: topology in lipid membranes. (2/241)
Equinatoxin II is a cysteineless pore-forming protein from the sea anemone Actinia equina. It readily creates pores in membranes containing sphingomyelin. Its topology when bound in lipid membranes has been studied using cysteine-scanning mutagenesis. At approximately every tenth residue, a cysteine was introduced. Nineteen single cysteine mutants were produced in Escherichia coli and purified. The accessibility of the thiol groups in lipid-embedded cysteine mutants was studied by reaction with biotin maleimide. Most of the mutants were modified, except those with cysteines at positions 105 and 114. Mutants R144C and S160C were modified only at high concentrations of the probe. Similar results were obtained if membrane-bound biotinylated mutants were tested for avidin binding, but in this case three more mutants gave a negative result: S1C, S13C and K43C. Furthermore, mutants S1C, S13C, K20C, K43C and S95C reacted with biotin only after insertion into the lipid, suggesting that they were involved in major conformational changes occurring upon membrane binding. These results were further confirmed by labeling the mutants with acrylodan, a polarity-sensitive fluorescent probe. When labeled mutants were combined with vesicles, the following mutants exhibited blue-shifts, indicating the transfer of acrylodan into a hydrophobic environment: S13C, K20C, S105C, S114C, R120C, R144C and S160C. The overall results suggest that at least two regions are embedded within the lipid membrane: the N-terminal 13-20 region, probably forming an amphiphilic helix, and the tryptophan-rich 105-120 region. Arg144, Ser160 and residues nearby could be involved in making contacts with lipid headgroups. The association with the membrane appears to be unique and different from that of bacterial pore-forming proteins and therefore equinatoxin II may serve as a model for eukaryotic channel-forming toxins. (+info)ATP-induced opposite changes in the local environments around Cys(697) (SH2) and Cys(707) (SH1) of the myosin motor domain revealed by the prodan fluorescence. (3/241)
To obtain a consistent view of the nucleotide-induced conformational changes around Cys(697) (SH2) and Cys(707) (SH1) in skeletal myosin subfragment-1 (S-1), the two thiols were labeled with the same environmentally sensitive fluorophore, 6-acyl-2-dimethylaminonaphthalene group, using 6-acryloyl-2-dimethylaminonaphthalene (acrylodan, AD) and 6-bromoacetyl-2-dimethylaminonaphthalene (BD), respectively. The resultant fluorescent derivatives, AD-S-1 and BD-S-1, have the same fluorophore at either SH2 or SH1, which was verified by inspections of changes in the ATPases and the localization of fluorescence after tryptic digestion and CNBr cleavage for the two derivatives. Especially, AD was found to be a very useful fluorescent reagent that readily reacts with only SH2 of S-1. Measurements of the nucleotide-induced changes in fluorescence emission spectra of AD-S-1 and BD-S-1 suggested that during ATP hydrolysis the environment around the fluorophore at SH2 is very distinct from that around the fluorophore at SH1, being defined as that the former has the hydrophobic and closed characteristics, whereas the latter has the hydrophilic and open ones. The KI quenching study of the fluorescence of the two S-1 derivatives confirmed these results. The most straightforward interpretation for the present results is that during ATP hydrolysis, the helix containing SH2 is buried in hydrophobic side chains and rather reinforced, whereas the adjacent helix containing SH1 moves away from its stabilizing tertiary structural environment. (+info)Two-photon fluorescence microscopy observation of shape changes at the phase transition in phospholipid giant unilamellar vesicles. (4/241)
Using the sectioning effect of the two-photon fluorescence microscope, we studied the behavior of phospholipid giant unilamellar vesicles (GUVs) composed of pure diacylphosphatidylcholine phospholipids during the gel-to-liquid crystalline phase transition. We used the well-characterized excitation generalized polarization function (GP(ex)) of 6-dodecanoyl-2-dimethylamine-naphthalene (LAURDAN), which is sensitive to the changes in water content in the lipid vesicles, to monitor the phase transition in the GUVs. Even though the vesicles do not show temperature hysteresis at the main phase transition, we observed different behaviors of the vesicle shape, depending on how the GUV sample reaches the main phase transition. During the cooling cycles, we observed an increase in the vesicle diameter at the phase transition ( approximately 0.5-1%), followed by a decrease in the diameter when the vesicle reached the gel phase. During the heating cycles and close to the phase transition temperature, a surprising behavior is observed, showing a sequence of different vesicle shapes as follows: spherical-polygonal-ellipsoidal. We attribute these changes to the effect of lipid domain coexistence on the macroscopic structure of the GUVs. The "shape hysteresis" in the GUVs is reversible and largely independent of the temperature scan rate. In the presence of 30 mol% of cholesterol the events observed at the phase transition in the GUVs formed by pure phospholipids were absent. (+info)Hydration of lipoplexes commonly used in gene delivery: follow-up by laurdan fluorescence changes and quantification by differential scanning calorimetry. (5/241)
Lipoplexes, which are formed spontaneously between cationic liposomes and negatively charged nucleic acids, are commonly used for gene and oligonucleotide delivery in vitro and in vivo. Being assemblies, lipoplexes can be characterized by various physicochemical parameters, including size distribution, shape, physical state (lamellar, hexagonal type II and/or other phases), sign and magnitude of electrical surface potential, and level of hydration at the lipid-DNA interface. Only after all these variables will be characterized for lipoplexes with a broad spectrum of lipid compositions and DNA/cationic lipid (L(+)) mole (or charge) ratios can their relevance to transfection efficiency be understood. Of all these physicochemical parameters, hydration is the most neglected, and therefore the focus of this study. Cationic liposomes composed of DOTAP without and with helper lipids (DOPC, DOPE, or cholesterol) or of DC-Chol/DOPE were complexed with pDNA (S16 human growth hormone) at various DNA(-)/L(+) charge ratios (0.1-3.2). (DOTAP=N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride; DC-Chol=(3beta-[N-(N',N'-dimethylaminoethane)-carbamoyl]-cholester ol; DOPC=1, 2-dioleoyl-sn-glycero-3-phosphocholine; DOPE=1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine). The hydration levels of the different cationic liposomes and the DNA separately are compared with the hydration levels of the lipoplexes. Two independent approaches were applied to study hydration. First, we used a semi-quantitative approach of determining changes in the 'generalized polarization' (GP) of laurdan (6-dodecanoyl-2-dimethylaminonaphthalene). This method was recently used extensively and successfully to characterize changes of hydration at lipid-water interfaces. Laurdan excitation GP at 340 nm (GP(340)DOTAP. The GP(340) of lipoplexes of all lipid compositions (except those based on DC-Chol/DOPE) was higher than the GP(340) of the cationic liposomes alone and increased with increasing DNA(-)/L(+) charge ratio, reaching a plateau at a charge ratio of 1. 0, suggesting an increase in dehydration at the lipid-water interface with increasing DNA(-)/L(+) charge ratio. Confirmation was obtained from the second method, differential scanning calorimetry (DSC). DOTAP/DOPE lipoplexes with charge ratio 0.44 had 16.5% dehydration and with charge ratio 1.5, 46.4% dehydration. For DOTAP/Chol lipoplexes with these charge ratios, there was 17.9% and 49% dehydration, respectively. These data are in good agreement with the laurdan data described above. They suggest that the dehydration occurs during lipoplex formation and that this is a prerequisite for the intimate contact between cationic lipids and DNA. (+info)Electrostatic properties of membranes containing acidic lipids and adsorbed basic peptides: theory and experiment. (6/241)
The interaction of heptalysine with vesicles formed from mixtures of the acidic lipid phosphatidylserine (PS) and the zwitterionic lipid phosphatidylcholine (PC) was examined experimentally and theoretically. Three types of experiments showed that smeared charge theories (e.g., Gouy-Chapman-Stern) underestimate the membrane association when the peptide concentration is high. First, the zeta potential of PC/PS vesicles in 100 mM KCl solution increased more rapidly with heptalysine concentration (14.5 mV per decade) than predicted by a smeared charge theory (6.0 mV per decade). Second, changing the net surface charge density of vesicles by the same amount in two distinct ways produced dramatically different effects: the molar partition coefficient decreased 1000-fold when the mole percentage of PS was decreased from 17% to 4%, but decreased only 10-fold when the peptide concentration was increased to 1 microM. Third, high concentrations of basic peptides reversed the charge on PS and PC/PS vesicles. Calculations based on finite difference solutions to the Poisson-Boltzmann equation applied to atomic models of heptalysine and PC/PS membranes provide a molecular explanation for the observations: a peptide adsorbing to the membrane in the presence of other surface-adsorbed peptides senses a local potential more negative than the average potential. The biological implications of these "discreteness-of-charge" effects are discussed. (+info)Two photon fluorescence microscopy of coexisting lipid domains in giant unilamellar vesicles of binary phospholipid mixtures. (7/241)
Images of giant unilamellar vesicles (GUVs) formed by different phospholipid mixtures (1,2-dipalmitoyl-sn-glycero-3-phosphocholine/1, 2-dilauroyl-sn-glycero-3-phosphocholine (DPPC/DLPC) 1:1 (mol/mol), and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine/1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPE/DPPC), 7:3 and 3:7 (mol/mol) at different temperatures were obtained by exploiting the sectioning capability of a two-photon excitation fluorescence microscope. 6-Dodecanoyl-2-dimethylamino-naphthalene (LAURDAN), 6-propionyl-2-dimethylamino-naphthalene (PRODAN), and Lissamine rhodamine B 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (N-Rh-DPPE) were used as fluorescent probes to reveal domain coexistence in the GUVs. We report the first characterization of the morphology of lipid domains in unsupported lipid bilayers. From the LAURDAN intensity images the excitation generalized polarization function (GP) was calculated at different temperatures to characterize the phase state of the lipid domain. On the basis of the phase diagram of each lipid mixture, we found a homogeneous fluorescence distribution in the GUV images at temperatures corresponding to the fluid region in all lipid mixtures. At temperatures corresponding to the phase coexistence region we observed lipid domains of different sizes and shapes, depending on the lipid sample composition. In the case of GUVs formed by DPPE/DPPC mixture, the gel DPPE domains present different shapes, such as hexagonal, rhombic, six-cornered star, dumbbell, or dendritic. At the phase coexistence region, the gel DPPE domains are moving and growing as the temperature decreases. Separated domains remain in the GUVs at temperatures corresponding to the solid region, showing solid-solid immiscibility. A different morphology was found in GUVs composed of DLPC/DPPC 1:1 (mol/mol) mixtures. At temperatures corresponding to the phase coexistence, we observed the gel domains as line defects in the GUV surface. These lines move and become thicker as the temperature decreases. As judged by the LAURDAN GP histogram, we concluded that the lipid phase characteristics at the phase coexistence region are different between the DPPE/DPPC and DLPC/DPPC mixtures. In the DPPE/DPPC mixture the coexistence is between pure gel and pure liquid domains, while in the DLPC/DPPC 1:1 (mol/mol) mixture we observed a strong influence of one phase on the other. In all cases the domains span the inner and outer leaflets of the membrane, suggesting a strong coupling between the inner and outer monolayers of the lipid membrane. This observation is also novel for unsupported lipid bilayers. (+info)A further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special reference to the chemicals 2-mercaptobenzothiazole (MBT), aniline, phenyl-beta-naphthylamine and o-toluidine. (8/241)
OBJECTIVES: To investigate mortality and cancer morbidity in workers from a factory manufacturing chemicals for the rubber industry. METHODS: The mortality (1955-96) and cancer morbidity experience (1971-92) of a cohort of 2160 male production workers from a chemical factory in north Wales were investigated. All subjects had at least 6 months employment at the factory and some employment in the period 1955-84. Detailed job histories were abstracted from company computerised records and estimates of individual cumulative exposure to 2-mercaptobenzothiazole (MBT) and its derivatives were obtained, with a job exposure matrix derived by a former factory hygienist. Durations of employment in the aniline, phenyl-beta-naphthylamine (PBN) and o-toluidine departments were also calculated. Two analytical approaches were used, indirect standardisation and Poisson regression. RESULTS: Based on serial rates for the general population of England and Wales, observed mortality for the total cohort was close to expectation for all causes (observed (obs) deaths 1131, expected (exp) deaths 1114.5, standardised mortality ratio (SMR) 101), and for all cancers (obs 305, exp 300.2, SMR 102). There was a significant (p < 0.05) excess mortality from cancer of the bladder in the 605 study subjects potentially exposed to one or more of the four chemicals being investigated (obs 9, exp 3.25, SMR 277, 95% confidence interval (95% CI) 127 to 526). This excess was dependent primarily on deaths occurring > 20 years after first exposure in those who started employment before 1955 (obs 7, exp 1.25, SMR 560, 95% CI 225 to 1154, p < 0.001). There were 30 subjects in the total study cohort who, on the basis of death certificates or cancer registration particulars, had had malignant bladder cancer. In separate analyses of the four exposure history variables (after adjustment for age), Poisson regression showed significant positive trends for risk of notification of bladder cancer increasing with cumulative duration of employment in the PBN (p < 0.001) and o-toluidine departments (p < 0.01); similar findings were not obtained for cumulative exposure to MBT or for duration of employment in the aniline department. In a simultaneous analysis of all four chemical exposure variables, a significant positive trend remained for duration of employment with exposure to PBN (p < 0.05). Further analyses of all cases of bladder cancer (malignant and benign diagnoses) used employment histories lagged by 15 years; similar findings were obtained. CONCLUSIONS: It seems likely that some members of this cohort have had occupational bladder cancer. Confident interpretation is difficult because of small numbers in the exposed subcohorts, relatively crude measures of exposure assessment for the four chemicals under study, and presence of unconsidered potential chemical confounders. The simplest interpretation of the findings about bladder cancer may be that PBN (or a chemical reagent or chemical intermediate associated with its production at this factory in the 1930s and 1940s) is a bladder carcinogen. Priority should be given, however, to obtaining information on the cancer experience of other working populations exposed to PBN or to o-toluidine. (+info)2 (7213): 1157-63. doi:10.1016/s0140-6736(61)90839-x. PMID 13888312. Boyland E, Dukes CE, Grover PL, Mitchley BC (1962). "The ... 2 (6): 299-309. PMC 1940220 . PMID 18865338. Dukes CE, Morgan CN (1948). "Double carcinoma of the rectum and recto-sigmoid ... 2 (2): 95-8. doi:10.1136/jcp.2.2.95. PMC 1023239 . PMID 16810849. Dukes CE, Masina F (1949). "Classification of epithelial ... 2 (4848): 1262-4. doi:10.1136/bmj.2.4848.1262. PMC 2030259 . PMID 13106406. Dukes CE, Cooke WT, Butler EC (1953). "Discussion ...
1-Naphthylamine is reacted with cyanogen bromide to give 2. Treatment of this intermediate with 3-ethyl-N-methylaniline leads ... 37 (2): 260. doi:10.1021/jm00028a009. PMID 8295213. E. Weber, J. F. W. Keana, WO 9112797 ; eidem, U.S. Patent 5,262,568 (1991, ... 2004 Mar;4(2):131-6. PMID 15032709 Staff, Boston Business Journal. May 7, 1998. CNSI appoints new president, CEO Staff, ICIS. ... 1994 Jan 21;37(2):260-7. PMID 8295213 Muir KW, Grosset DG, Gamzu E, Lees KR. Pharmacological effects of the non-competitive ...
... (2-amino-2'-hydroxy-1,1'-binaphthyl) is an organic molecule used for asymmetric catalysis. NOBIN is related to BINOL and ... NOBIN is prepared by oxidative cross coupling of 2-naphthol and 2-naphthylamine. The oxidative source is metal ions in solution ...
... , a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of ... N,N-Bis(2-Chloroethyl)-2-Naphthylamine (Chlornaphazine), International Agency for Research on Cancer. ... Videbaek, A.; Kaae, S. (1954). "2-Naphthylbis(chloroethyl)amine in the treatment of malignant diseases, particularly Hodgkin's ...
However, it is a weaker bidentate ligand as the nitrogen atom in the naphthylamine group is weakly coordinating due to the ... This compound can be prepared by the reaction of 1-naphthylamine with 2-chloroethanamine. It is commercially available as the ... N-(1-Naphthyl)ethylenediamine undergoes most reactions typical to naphthylamine and primary amines such as diazotation. Similar ...
antioxidant: N-phenyl-2-naphthylamine. 0.5%. 0.5%. 0.5% pigment. 0.5% Sudan IV (reddish brown to red). 0.5% Sudan I (red-orange ... Explosia's brief historical document states it was 1964,[2] but most other credible sources state it was in 1966. Most of these ... First, ethylene glycol dinitrate was used, later switched to 2,3-dimethyl-2,3-dinitrobutane (DMDNB) or p-mononitrotoluene (1- ... 2] Batches of Semtex made before 1990, however, are untagged, though it is not known whether there are still major stocks of ...
Pyrrolidonyl-beta-naphthylamide P-Dimethylaminocinnamaldehyde Pyroglutamic acid 2-Naphthylamine Panosian KJ, Edberg SC (March ...
3.0.CO;2-Q. PMID 10931463. Osch, Frits H. M. van; Jochems, Sylvia H. J.; Schooten, Frederik-Jan van; Bryan, Richard T.; Zeegers ... 2-Naphthylamine, which is found in cigarette smoke, has also been shown to increase bladder cancer risk. Occupations at risk ... BCG immunotherapy is effective in up to 2/3 of the cases at this stage, and in randomized trials has been shown to be superior ... 48 (2): 202-5; discussion 205-6. doi:10.1016/j.eururo.2005.04.006. PMID 15939524. Grossman HB, Natale RB, Tangen CM, et al. ( ...
2-NA) was involved in human bladder tumorigenesis. With Adolph Strümpell (1853-1925), the eponymous "Strümpell-Leichtenstern ... In 1898 he suspected that the compound 2-naphthylamine ( ...
In the presence of bacteria with pyrrolidonyl peptidase, it is broken down to pyroglutamic acid and 2-naphthylamine. To detect ...
Sudan Black is formed by coupling of diazotized 4-phenylazo-1-naphthylamine with 2,3-dihydro-2,2-dimethyl-1H-perimidine. ... Therefore the main product expected was 2,3-dihydro-2,2dimethyl-6-[(4-phenylazo-1-naphthalenyl)-azo]-1H-perimidine. However the ... 3-dihydro-2,2dimethyl-4-[(4-phenylazo-1-naphthalenyl)-azo]-1H-perimidine. "Histochemistry. 1977 Dec 7;54(3):237-50. Sudan Black ...
... specifically 2-Naphthylamine). The only supplier in the United States, the William J. Stange Company, subsequently stopped ...
2,2'-Bisindoles can be bridged to a seven-membered ring structure by 3-dimethylaminocrolein and oxalyl chloride via the ... The amidine formed with 2-naphthylamine and the dimethyl sulfate adduct can be cyclized with sodium methoxide to give benzo[f] ... The use of 3-dimethylaminoacrolein for the synthesis of 2-chloronicotinic acid (2-CNA) is of industrial interest as an ... The resulting esters of 2-chloropyridine carboxylic acid can be hydrolyzed smoothly to 2-chloronicotinic acid. It reacts weakly ...
ISBN 0-471-60180-2. Shine, H. J.; Zmuda, H.; Park, K. H.; Kwart, H.; Horgan, A. G.; Collins, C.; Maxwell, B. E. (1981). " ... As with some other aromatic amines such as 2-naphthylamine, benzidine has been significantly withdrawn from use in most ... First, the nitrobenzene is converted to 1,2-diphenylhydrazine, usually using iron powder as the reducing agent. Treatment of ... These derivatives include, in order of scale, the following: 3,3'-Dichlorobenzidine o-tolidine, 2,2'-dimethyl-4,4'-benzidine o- ...
4-tetrahydro-1-naphthylamine) CP-39,332 (N-methyl-4-phenyl-1,2,3,4-tetrahydro-2-naphthylamine) Cyproheptadine [4-(5H-dibenz-[a, ... 4-Tetrahydro-1-Naphthylamine, a New Uptake Inhibitor with Selectivity for Serotonin" (PDF). The Journal of Pharmacology and ... Koe, BK; Weissman, A; Welch, WM; Browne, RG (September 1983). "Sertraline, 1S,4S-N-Methyl-4-(3,4-Dichlorophenyl)-1,2,3, ... 2] doi:10.1021/ol0257934 Certain aromatic substitutients have a potentiating effect (e.g., p-Br), whereas others negate the ...
2-Amino-1,2-dihydronapthalene (2-ADN), also known as 2-aminodilin (2-AD), is a stimulant drug. It is a rigid analogue of ... 2-Aminoindane 2-Aminotetralin 2-Naphthylamine Hathaway BA, Nichols DE, Nichols MB, Yim GK (May 1982). "A new, potent, ... It is closely related to 2-aminotetralin (2-amino-1,2,3,4-tetrahydronaphthalene), which also substitutes for amphetamine, and ... 2-dihydronaphthalene". Journal of Medicinal Chemistry. 25 (5): 535-8. doi:10.1021/jm00347a011. PMID 6123601. ...
Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N- ... 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p- ...
November 2, 2009 ‐‐ IARC has updated the cancer assessments of several personal habits and household exposures that cause ... 2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... 2-chloroaniline) (MOCA) MOPP and other combined chemotherapy including alkylating agents Mustard gas (Sulfur mustard) 2- ... Naphthylamine Neutron radiation Nickel compounds2 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) N-Nitrosonornicotine ...
Supply is prohibited, during the course of work or for use at work, of (reg.4(3), (4)/ Sch.2, item.11): Any of the substances ... Use of the following substances is prohibited for the purposes specified (reg.4(1)/ Sch.2): The following are excluded from the ... The assessment must include consideration of any information provided by the supplier of a substance (CHIPS) (reg.6(2)(b)) and ... ISBN 0-7545-3318-2. Health and Safety Executive (2003). COSHH essentials: Easy steps to control chemicals. Control of ...
This might take only 1-2 minutes. Then the sample is thoroughly rinsed in water (for one to two hours). Afterwards, the stained ... Alternatively, the product of an acid-catalyzed condensation of 4-nitroso-N,N-dialkylaniline with 2-naphthol (a salt of 9-( ... 2.0.CO;2. PMID 11202363. Kanitz, Andreas; Hartmann, Horst (1999). "Preparation and Characterization of Bridged Naphthoxazinium ... Nile Blue and related naphthoxazinium dyes can be prepared by acid-catalyzed condensation of either 5-(dialkylamino)-2- ...
1-naphthylamine MeSH D04.615.638.845.800 --- sertraline MeSH D04.615.638.850 --- 2-naphthylamine MeSH D04.615.638.870 --- 1- ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 --- levobunolol MeSH D04.615.638.960.585 --- mibefradil MeSH ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 --- fusidic acid MeSH D04.808.247.808.607 --- lanosterol MeSH D04.808.247.808. ... t-2 toxin MeSH D04.345.891.900 --- trichodermin MeSH D04.615.117.050 --- dithranol (anthralin) MeSH D04.615.117.159 --- ...
2, Winter 1999, at 95. Loeb (1999) Peterson, M (2007). "The precautionary principle should not be used as a basis for decision- ... 78 (2): 71-8. doi:10.1006/enrs.1997.3808. PMID 9719610. Jamie Lincoln Kitman (2000-03-20). "The Secret History of Lead". The ... 78 (2): 79-85. doi:10.1006/enrs.1997.3807. PMID 9719611. Kehoe RA (1953). "Experimental Studies on the Inhalation of Lead by ... ISBN 978-0-520-27325-2. Zhang, Sarah. "Leaded Fuel Is a Thing of the Past-Unless You Fly a Private Plane". Mother Jones. Some ...
Naphthalene Naphthol 1-Naphthylamine 1,8-Bis(dimethylamino)naphthalene "NIOSH Pocket Guide to Chemical Hazards #0442". National ... When reduced by sodium in boiling amyl alcohol solution, it forms tetrahydro-3-naphthylamine, which exhibits the properties of ... 2-Naphthylamine is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. It also can ... 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. It is activated ...
Anilines and naphthylamines form more stable diazonium salts, which can be isolated in the crystalline form.[14] Diazonium ... 2. R. 1. ,. :. ⏟. a. m. i. n. e. +. R. 3. −. C. O. ‖. −. OH. ⏟. carboxylic acid. −. ,. H. −. N. +. ,. R. 2. R. 1. ,. −. H. +. R ... 2. R. 1. ,. −. C. O. ‖. −. R. 3. ⏟. a. m. i. d. e. +. H. 2. O. ⏟. w. a. t. e. r. {\displaystyle {\underbrace {\ce {H-\!\!{\ ... 2. +. HNO. 2. +. HX. ⟶. AN. +. 2. X. −. +. 2. H. 2. O. {\displaystyle {\ce {ANH2 + HNO2 + HX -, AN + 2X^- + 2 H2O}}}. ...
... but these effects are now attributed to naphthylamines, not anilines.[6] ... 2 C6H5NH2 + CH2O → CH2(C6H4NH2)2 + H2O. The resulting diamine is the precursor to 4,4'-MDI and related diisocyanates. ... C6H5NH2 + 2 CH3OH → C6H5N(CH3)2 + 2H2O. N-Methylaniline and dimethylaniline are colorless liquids with boiling points of 193- ... Aniline is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is ...
Anilines and naphthylamines form more stable diazonium salts, which can be isolated in the crystalline form.[14] Diazonium ... 2. R. 1. ,. :. ⏟. a. m. i. n. e. +. R. 3. −. C. O. ‖. −. OH. ⏟. carboxylic acid. −. ,. H. −. N. +. ,. R. 2. R. 1. ,. −. H. +. R ... 2. R. 1. ,. −. C. O. ‖. −. R. 3. ⏟. a. m. i. d. e. +. H. 2. O. ⏟. w. a. t. e. r. {\displaystyle {\underbrace {\ce {H-\!\!{\ ... 2. +. HNO. 2. +. HX. ⟶. AN. +. 2. X. −. +. 2. H. 2. O. {\displaystyle {\ce {ANH2 + HNO2 + HX -, AN + 2X^- + 2 H2O}}}. ...
Naphthalene Naphthol 1-Naphthylamine 1,8-Bis(dimethylamino)naphthalene "NIOSH Pocket Guide to Chemical Hazards #0442". National ... When reduced by sodium in boiling amyl alcohol solution, it forms tetrahydro-3-naphthylamine, which exhibits the properties of ... 2-Naphthylamine is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. It also can ... 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. It is activated ...
Testing Status of N-Phenyl-2-naphthylamine 10586-X. CASRN: 135-88-6. Formula: C16-H13-N. Synonyms/Common Names. *N-Phenyl-2- ... Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies ... Citation: Metabolism of N-phenyl-2-naphthylamine (PNA) after Feeding to Fischer 344 Rats. October 15, 1986 ...
Phenyl(b-naphthyl)amine *Phenyl-b-naphthylamine *N-Phenyl-b-naphthylamine *Stabilizator AR Last updated: 11 March 1998 See Also ... 7. Wang, H., Wang, D. & Dzeng, R. (1984) Carcinogenicity of N-phenyl-1-naphthylamine and N-phenyl-2-naphthylamine in mice. ... naphthylamine in rats after intragastric administration. Cancer Lett., 16, 203-206 4. Green, U., Holste, J. & Spikermann, A.R ... N-Phenyl-2-naphthylamine is not classifiable as to its carcinogenicity to humans (Group 3). For definition of the italicized ...
N-PHENYL-2-NAPHTHYLAMINE. VOL.: 16 (1978) (p. 325) 5. Summary of Data Reported and Evaluation1. 5.1 Animal data. N-Phenyl-2- ... naphthylamine has been tested in mice by oral and single subcutaneous administration and in a small number of dogs by oral ... In one study, in one factory, of men with known exposure to N-phenyl-2-naphthylamine in rubber processing under controlled ... In the latter study, exposure was mixed but probably included exposure to N-phenyl-2-naphthylamine for many workers. These ...
What is 2-naphthylamine? Meaning of 2-naphthylamine medical term. What does 2-naphthylamine mean? ... Looking for online definition of 2-naphthylamine in the Medical Dictionary? 2-naphthylamine explanation free. ... 2-naphthylamine. Also found in: Wikipedia. 2-naphthylamine. an industrial chemical identified as a urinary bladder carcinogen. ... Nitrosamine, 2-naphthylamine, and 4-aminobiphenyl are possible carcinogenic agents found in cigarette smoke3.. RISK FACTORS FOR ...
4-tetrahydro-1-naphthylamine. Regulatory process names 1 CAS names 1 IUPAC names 2 Other identifiers 2 ...
N-ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine. ↓Other names: Regulatory process names [2] IUPAC names [2] ... N-Ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine * N-ethyl-1-[(E)-2-{4-[(E)-2-phenyldiazen-1-yl]phenyl}diazen-1-yl]naphthalen ...
Find quality suppliers and manufacturers of 2-Naphthylamine-5,7-disulfonic acidfor price inquiry.where to buy 2-Naphthylamine-5 ... 7-disulfonic acid.Also offer free database of 2-Naphthylamine-5,7-disulfonic acid including MSDS sheet(poisoning, toxicity, ... naphthylamine -1,5,7 - 3-sulfonic acid in water at 110-120 °C 4h, cooling and filtering, washing in sodium sulfate solution, ... Naphthylamine-5,7-disulfonic acid;6-AMINO-NAPHTHALENE-1,3-DISULFONIC ACID;Naphthalene-1,3-disulfonic acid, 6-amino-;6-Amino-1, ...
... α-naphthylamine (CAS 2933-59-7) Market Research Report 2018 aims at providing comprehensive data on n-(2-hydroxyethyl)-α- ... α-naphthylamine prices in other regions. 7. N-(2-HYDROXYETHYL)-α-NAPHTHYLAMINE END-USE SECTOR 7.1. N-(2-hydroxyethyl)-α- ... α-NAPHTHYLAMINE PATENTS. Abstract. Description. Summary of the invention. Detailed description of the invention. 5. N-(2- ... α-naphthylamine consumers globally. - Europe. - Asia. - North America. - Other regions. *Please note that N-(2-Hydroxyethyl)-α- ...
1-nitro-2-naphthylamine ; physical and chemical property of 606-57-5, 1-nitro-2-naphthylamine is provided by ChemNet.com ... CAS No: 606-57-5, Chemical Name: 1-nitro-2-naphthylamine. Home , Products , Suppliers , Offer to Buy , Offer to Sell , Chemical ... 1-nitro-2-naphthylamine. Synoniemen. 2-Naphthylamine, 1-nitro-; 1-Nitro-2-naphthylamine; 2-Amino-1-nitronaphthalene; 4-12-00- ... ChemNet , CAS , 606-57-5 1-nitro-2-naphthylamine. 606-57-5 1-nitro-2-naphthylamine. Naam product. ...
Naphthylamine and 2-Nitronaphtalene metabolism Metabolism and binding studies with 2-Naphthylamine and many other arylamines ... 2-Naphthylamine and 2-Hydroxyamino-naphthalene conjugate with UDP-D-glucuronic acid and form respectively 2-Naphthylamine-N- ... In addition, both 2-Hydroxyamino-naphthalene and 2-Amino-1-Naphthol form sulphate conjugates N-Hydroxy-2-naphthyl-sulfamic acid ... 2-Nitronaphthalene is oxidized to 2-Nitronaphthalene-5,6-oxide and 2-Nitronaphthalene-7,8-oxide by following enzymes: ...
68-dichloro-2-methyl-benzoebenzothiophene-4-carboxylic-acid-albumin.html. *4-5-methyl-2-phenyl-phenoxyphthalonitrile-albumin. ... 2-methylspiro56-dihydrodibenzo12-a12-ecycloheptene-111-isoindoline-albumin.html. *pyrrol21-aisoquinoline-123-tricarboxylic-acid ... Prediction result: Albumin ligand (prediction accuracy: 92.1%), binding site 2 (prediction accuracy: 80.0%). Submit ... Prediction : 1-o-tolylazo-2-naphthylamine - albumin. Your feedback has been submited, thank you! ...
N-Phenyl-1-naphthylamine(90-30-2) Density MSDS Formula Use,If You also need to N-Phenyl-1-naphthylamine(90-30-2) Other ... ChemicalBook provide Chemical industry users with N-Phenyl-1-naphthylamine(90-30-2) Boiling point Melting point, ... N-Phenyl-1-naphthylamine Basic information Product Name:. N-Phenyl-1-naphthylamine. Synonyms:. *N-Phenyl-1-naphthylaMine ... N-Phenyl-1-naphthylamine is probably combustible.. Contact allergens. Phenyl-alpha-naphthylamine is contained in some rubbers ...
2-naphthylamine 91-59-8 Precursor and Downstream products, 2-naphthylamine Precursor products, 2-naphthylamine Downstream ... Current Page: Home › Chemical Dictionary › 91-59-8 › 2-naphthylamine 91-59-8 Precursor and Products ... 86-60-2 131-27-1 81-05-0 117-62-4 540-69-2 60-80-0 7664-41-7 91-20-3 64-19-7 7664-93-9 32316-92-0 7647-01-0 64-17-5 580-13-2 71 ...
2-naphthylamine 91-59-8 MSDS report, 2-naphthylamine MSDS safety technical specifications search, 2-naphthylamine safety ... ADR/RID: beta-NAPHTHYLAMINE, SOLID. IMDG: beta-NAPHTHYLAMINE, SOLID. IATA: beta-Naphthylamine, solid Transport hazard class(es) ... β-Naphthylamine. Synonyms. 2-Aminonaphthalene. Formula : C10H9N Molecular Weight : 143,19 g/mol Component Concentration 2- ... Naphthylamine. CAS-No. 91-59-8 - EC-No. 202-080-4 Index-No. 612-022-00-3 Section 4. FIRST AID MEASURES. Description of first ...
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2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride - Similar structures search, synonyms, formulas, resource links, and ... 1S/C20H25N.ClH/c1-19(2)15-20(21-3,13-16-9-5-4-6-10-16)14-17-11-7-8-12-18(17)19;/h4-12,21H,13-15H2,1-3H3;1H. Download. ... Substance Name: 2-Naphthylamine, 1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride. RN: 31209-75-3. InChIKey: ...
2 5 smoker-yr of. exposure during. childhood. 2.07 (CI, 1.16-3.68). Matched for age, sex,. and county of. residence; relative. ... 1986; Blot and Fraumeni 1986] (Table 2).. Hole et al. [1989]. Hole et al. [1989] updated an earlier cohort study [Gillis et al ... 1989], only 2 deaths from lung cancer occurred in the unexposed group and 7 in the exposed group, compared with 147 deaths from ... Each patient was matched by age, hospital, and admission date to 2 controls of the same sex who did not have lung cancer (for ...
N-Phenyl-1-Naphthylamine CAS 90-30-2 FOB Price: US $ 5100-5300 / Ton. Min. Order: 1 Ton ...
2-Chloro-4,6-diphenyl-1,3,5-triazine TCI-C2703 , 3842-55-5 , C15H10ClN3 , TCI America 2-Chloro-4,6-diphenyl-1,3,5-triazine ... 2,4,6-Triphenyl-1,3,5-triazine TCI-T2785 , 493-77-6 , C21H15N3 , TCI America 2,4,6-Triphenyl-1,3,5-triazine ... 2-Chlorobenzimidazole TCI-C1719 , 4857-06-1 , C7H5N2Cl , TCI America 2-Chlorobenzimidazole ... N-Benzyl-2-naphthylamine TCI-B3088 , 13672-18-9 , C17H15N , TCI America N-Benzyl-2-naphthylamine ...
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Antioxidants for Hot Melt Adhesive Powder N-phenyl-2-naphthylamine PBN ANTIOXIDANT D ... Pbn Antioxidant D Supplier , Antioxidant D Supplier , N-phenyl-2-naphthylamine Antioxidant D Supplier ...
InChI=1S/C12H13N/c1-13(2)12-8-7-10-5-3-4-6-11(10)9-12/h3-9H,1-2H3 ... N,N-Dimethyl-«beta»-naphthylamine. *Formula: C12H13N. * ...
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- The first such association was observed in 1895 (Rehn 1895), and subsequent research among dyestuff workers identified the aromatic amines benzidine and 2-naphthylamine as bladder carcinogens (Case et al. (thefreedictionary.com)
- 1993. Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine. (cdc.gov)
- الخلاصـة: قاس الباحثون في بحيرة إدكو والبحر المتوسط، في منطقة المعدية، ثلاثة مركبات أمينية أروماتية هي (1-naphthylamine 2-naphthylamine, benzidine) في أنسجة عضلات السمك. (who.int)
- We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines (1-naphthylamine, 2-naphthylamine and benzidine) in the muscle tissue of fish. (who.int)
- Nous avons réalisé une estimation de la pollution dans le lac Edkou et en Méditerranée (région d'El-Maadiya), sur la base de trois amines aromatiques (1-naphthylamine, 2-naphthylamine et benzidine) dans les tissus musculaires de poissons. (who.int)
- arsenic compounds[a] Auramine production Benzidine Chlornaphazine Cyclophosphamide Magenta production 2-Naphthylamine Painting Rubber. (evidence.nhs.uk)
- Bladder transitional epithelial microsomes also activated o -dianisidine, 4-aminobiphenyl, and 2-naphthylamine to bind to protein and transfer RNA and benzidine and o -dianisidine to bind DNA. (aacrjournals.org)
- Occupational exposures to 4-aminobiphenyl, 2-naphthylamine, benzidine ( 10 ), and aromatic amines, such as o -toluidine ( 11 ), also play an important role in the initiation of bladder cancer. (aacrjournals.org)
- The chemicals include benzene and 2-naphthylamine , known human carcinogens, cadmium and n-nitrosodiethanolamine, which is associated with cancer in humans, and polonium-210, an element that emits alpha radiation. (thefreedictionary.com)
- Some of the major conceptual advances in chemical carcinogenesis made during the past several years have been (1) the discovery of the enzymatic activation of procarcinogens to reactive ultimate carcinogens, (2) the characterization of interactions of the active metabolites of many carcinogens with a variety of tissue nucleophiles including DNA, RNA, and protein, and (3)the development of model systems for a sequential analysis of the initiation phase of carcinogenesis. (springer.com)
- After N-oxidation of aromatic amines such as 4-aminobiphenyl or 2-naphthylamine by CYP1A2 in the liver, O-acetylation of the resulting hydroxylamine by NAT2 can produce unstable acetoxy esters that decompose to form highly electrophilic aryl nitrenium ion species. (thefreedictionary.com)
- 2) Many of them, particularly carcinogenic aromatic amines (AA) like 2-naphthylamine and 4-aminobiphenyl and polycyclic aromatic hydrocarbons (PAHs) are combustion products not detected in vapours of e-cigarettes and only in very small amounts in aerosol of tobacco heating systems (THS). (bmj.com)
- Naphthylamine is an aromatic amine which can be obtained from nitronaphthalene (with iron and hydrochloric acid) or naphthol with sodium acetate, ammonium chloride. (chemicalland21.com)
- More speci?cally, it relates to (1) a process for the preparation of quaterm'zed heterocyclic azo dyes, (2) to a process for the deoxygenation of mon azine oxides by the action of certain metals in an inert 15 solvent, (3) to a process for the deoxygenation of mon-' azine oxides with phosphorous trichloride in halogenated aromatic solvents and (4) to certain new azo derivatives of monazine oxides. (docme.ru)
- We synthesized a new HIL and HTL materials by using phenothiazinly moiety, 1,4-diphenothiazyl-benzene [DPtzB], 3′,7′,3″,7″-tetrakis(N-phenyl-2-naphthylamine)-1,4-diphenothiazyl-benzene [PNA-DPtzB]. (ingentaconnect.com)
- Aniline , phenylamine or aminobenzene is an organic compound with the formula C 6 H 5 NH 2 . (bionity.com)
- Aniline reacts with carboxylic acids [2] or more readily with acyl chlorides such as acetyl chloride to give amides. (bionity.com)
- Naphthylamine is the naphthalene homologues of aniline. (chemicalland21.com)
- Citation: Metabolism of N-phenyl-2-naphthylamine (PNA) after Feeding to Fischer 344 Rats. (nih.gov)
- N -Phenyl-2-naphthylamine was tested for carcinogenicity by oral administration in mice, rats, hamsters and dogs. (inchem.org)
- There is some evidence from one study of 19 human volunteers that up to 0.03% of a single 10-mg dose of N -phenyl-2-naphthylamine is converted to 2-naphthylamine. (inchem.org)
- Similarly, the urine of workers exposed to N -phenyl-2-naphthylamine was found to contain 2-naphthylamine, indicating that N -phenyl-2-naphthylamine is dephenylated in the human body [ref: (inchem.org)
- No data were available on the genetic effects of N -phenyl-2-naphthylamine in humans. (inchem.org)
- N -Phenyl-2-naphthylamine is not classifiable as to its carcinogenicity to humans (Group 3) . (inchem.org)
- 5. Wang, H., Dzeng, R. & Wang, D. (1982) The carcinogenicity of N -phenyl-2-naphthylamine in ICR mice (Chin. (inchem.org)
- 7. Wang, H., Wang, D. & Dzeng, R. (1984) Carcinogenicity of N -phenyl-1-naphthylamine and N -phenyl-2-naphthylamine in mice. (inchem.org)
- 8. You, X. & Yao, Y. (1981) Experimental study of inhalation carcinogenesis of N -phenyl-2-naphthylamine aerosol on mice (Chin. (inchem.org)
- N -Phenyl-2-naphthylamine has been tested in mice by oral and single subcutaneous administration and in a small number of dogs by oral administration. (inchem.org)
- In one study, in one factory, of men with known exposure to N -phenyl-2-naphthylamine in rubber processing under controlled conditions, there was no indication of an excess incidence of bladder tumours. (inchem.org)
- In the latter study, exposure was mixed but probably included exposure to N -phenyl-2-naphthylamine for many workers. (inchem.org)
- These findings do not permit an assessment of the presence or absence of an elevated risk for cancer of the urinary bladder in persons exposed to N -phenyl-2-naphthylamine. (inchem.org)
- 6-Aminonaphthalene-1,3-disulfonic acid (CAS NO. 118-33-2) is used for dye intermediates,mainly is the intermediates to produce J acid, double-J Acid, Phenyl J acid and scarlet acid. (lookchem.com)
- N-Phenyl-1-naphthylamine neutralizes acids in exothermic reactions to form salts plus water. (chemicalbook.com)
- ACUTE/CHRONIC HAZARDS: When heated to decomposition N-Phenyl-1-naphthylamine emits toxic fumes. (chemicalbook.com)
- Flash point data for N-Phenyl-1-naphthylamine are not available. (chemicalbook.com)
- N-Phenyl-1-naphthylamine is probably combustible. (chemicalbook.com)
- Phenyl-alpha-naphthylamine is contained in some rubbers and oils as an antioxidant of the amine group. (chemicalbook.com)
- It is closely related to phenyl-beta-naphthylamine and to di-beta-naphthyl-p-phenylenediamine, but without cross-reactivity. (chemicalbook.com)
- Boiled with carbon disulfide, it gives sulfocarbanilide (diphenyl thiourea), CS(NHC 6 H 5 ) 2 , which may be decomposed into phenyl isothiocyanate , C 6 H 5 CNS, and triphenyl guanidine, C 6 H 5 N=C(NHC 6 H 5 ) 2 . (bionity.com)
- Carcinogenicity of n-phenyl-1-naphthylamine and n-phenyl-2-naphthylamine in mice. (steunmijnclub.nl)
- Occupational exposure to N-phenyl-1-naphthylamine may occur through inhalation and dermal contact with this compound at workplaces where N-phenyl-1-naphthylamine is produced or used. (steunmijnclub.nl)
- Search results for N-Phenyl-1-naphthylamine at Sigma-Aldrich. (steunmijnclub.nl)
- On offer from us is Phenyl Alpha Naphthylamine Chemical, which is used in the chemical industry as an intermediate for dyestuff and food colors.Processed under the strict supervision of our deft auditors, we have take intense care to match the purity standards of the industry. (steunmijnclub.nl)
- One German company is the sole producer of N-phenyl-1-naphthylamine within the European Union. (steunmijnclub.nl)
- N-Phenyl-1-naphthylamine was used in a method for determination of the concentration of organolithium and organomagnesium reagents. (steunmijnclub.nl)
- The Undefined Acronym /Abbreviation/Slang NPN means probe N-phenyl-1-naphthylamine. (steunmijnclub.nl)
- 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. (wikipedia.org)
- however, a study of rubber workers who were not exposed to 2-naphthylamine did show an increased incidence of bladder tumours. (inchem.org)
- However, a broader study of rubber workers who had no exposure to 2-naphthylamine has shown an increased risk of bladder tumours. (inchem.org)
- Followed by glucuronidation and excretion of the glucuronides via the kidney, this reaction can account for the ability of 2-Naphthylamine to initiate tumours of the bladder [ 1 ]. (bio-rad.com)
- In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, vol 2. (springer.com)
- Conzelman GM Jr, Moulton JE, Flanders LE 3rd, Springer K, Crout DW (1969) Induction of transitional cell carcinomas of the urinary bladder in monkeys fed 2- naphthylamine. (springer.com)
- Erttirk E, Cohen SM, Price JM, Bryan GT (1969) Pathogenesis, histology, and transplant ability of urinary bladder carcinomas induced in albino rats by oral administration of N-[4-(5-nitro-2furyl)-2-thiazolyl] formamide. (springer.com)
- Prostaglandin H synthase and mixed-function oxidase-catalyzed bindings of 2-naphthylamine to protein and to transfer RNA were compared using liver and bladder microsomes. (aacrjournals.org)
- 2-Naphthylamine is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. (wikipedia.org)
- It also can be produced its acetyl derivative by heating 2-naphthol with ammonium acetate to 270-280 °C. It gives no color with iron(III) chloride. (wikipedia.org)
- 2-Hydroxyamino-naphthalene can spontaneously isomerize further into the 2-Amino-1-naphthol . (bio-rad.com)
- 2-Hydroxyamino-naphthalene is formed in the reaction of N-oxidation catalyzed by unspecific monooxygenase [ 2 ]. (bio-rad.com)
- 2-Hydroxyamino-naphthalene is formed by reduction of 2-Nitrosonaphthalene in the reaction of catalyzed by unknown oxidoreductase [ 9 ]. (bio-rad.com)
- Nitrosamine, 2-naphthylamine , and 4-aminobiphenyl are possible carcinogenic agents found in cigarette smoke3. (thefreedictionary.com)
- 8) The substances contributing to this disease are carcinogenic AA particularly 2-naphthylamine and 4-aminobiphenyl and PAHs. (bmj.com)
- a carcinogenic liquid, C 2 H 6 N 2 O, found in tobacco smoke and certain foods. (thefreedictionary.com)
- First, ethylene glycol dinitrate was used, later switched to 2,3-dimethyl-2,3-dinitrobutane (DMDNB) or p -mononitrotoluene (1-methyl-4- nitrobenzene ), which is used currently. (wikipedia.org)
- In another experiment, two rare kidney tumours were seen in female mice [ref: 2]. (inchem.org)
- November 2, 2009 ‐‐ IARC has updated the cancer assessments of several personal habits and household exposures that cause cancer, including tobacco, areca nut, alcohol, and household coal smoke. (wikipedia.org)
- 2) The Principal Regulations, the Regulations of 2003 and these Regulations may be cited together as the European Communities (Dangerous Substances and Preparations) (Marketing and Use) Regulations 2003 to 2004. (irishstatutebook.ie)
- For example, benzepyrene, 2-naphthylamine, and 4-aminobiphenyl are metabolized by the body's P450 system to form reactive substances that can chemically interact with DNA nucleotides and cause mutations ( 9 , 10 ). (pnas.org)
- 2-naphthylamine is also a chemical compound that had uses in dyeing, but today it is replaced with other less toxic substances. (mysite2.com)
- N-(2-Hydroxyethyl)-α-naphthylamine (CAS 2933-59-7) Market Research Report 2018 aims at providing comprehensive data on n-(2-hydroxyethyl)-α-naphthylamine market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
- N-(2-Hydroxyethyl)-α-naphthylamine (CAS 2933-59-7) Market Research Report 2018 contents were prepared and placed on the website in January, 2018. (marketpublishers.com)
- Please note that N-(2-Hydroxyethyl)-α-naphthylamine (CAS 2933-59-7) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
- Naphthylamine is the starting material in the dye manufacturing and rubber industry. (chemicalland21.com)
- Hydrogen-bonding-induced electron transfer from triplet N-N-dialkyl-l-naphthylamines to benzophenone via triplet exciplex' J.Phys.Chem.100・2. (nii.ac.jp)
- O 3 -activated 1-NA was stable for at least 4 h and could damage cellular DNA at 4° C. During ozonization, hydroperoxides were formed at levels equivalent to between 2 and 20 μ M of hydrogen peroxide and were eliminated by treatment with catalase. (ovid.com)
- naphthylamine in rats after intragastric administration. (inchem.org)
- The online version of this article ( https://doi.org/10.1007/s11270-019-4112-2 ) contains supplementary material, which is available to authorized users. (springer.com)
- Naphthylamines --Toxicology. (epa.gov)