Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Fluorescence Polarization: Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.Fluoroimmunoassay: The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.Fluorescence: The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.Europium: Europium. An element of the rare earth family of metals. It has the atomic symbol Eu, atomic number 63, and atomic weight 152. Europium is used in the form of its salts as coatings for cathode ray tubes and in the form of its organic derivatives as shift reagents in NMR spectroscopy.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Xeroderma Pigmentosum Group D Protein: A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCLEOTIDE EXCISION REPAIR, and mutations in this protein are associated with XERODERMA PIGMENTOSUM.Aldehyde Dehydrogenase: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.IndolizinesNitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.ThiophenesHeterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Raloxifene: A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.Tars: Viscous materials composed of complex, high-molecular-weight compounds derived from the distillation of petroleum or the destructive distillation of wood or coal. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Sulfur-Reducing Bacteria: A group of gram-negative, anaerobic bacteria that is able to oxidize acetate completely to carbon dioxide using elemental sulfur as the electron acceptor.Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.Peptide Elongation Factor G: Peptide Elongation Factor G catalyzes the translocation of peptidyl-tRNA from the A to the P site of bacterial ribosomes by a process linked to hydrolysis of GTP to GDP.Impetigo: A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Thiolester HydrolasesStaphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Deoxyribonucleotides: A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.2-Hydroxy-5-nitrobenzyl Bromide: A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules. Used for 'active site' enzyme studies and other protein studies. Sometimes referred to as Koshland's reagent.Ribonucleotides: Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)Deoxycytosine Nucleotides: Cytosine nucleotides which contain deoxyribose as the sugar moiety.Deoxyribonucleosides: A purine or pyrimidine base bonded to DEOXYRIBOSE.Templates, Genetic: Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Thymine Nucleotides: Phosphate esters of THYMIDINE in N-glycosidic linkage with ribose or deoxyribose, as occurs in nucleic acids. (From Dorland, 28th ed, p1154)DNA Replication: The process by which a DNA molecule is duplicated.Kinetics: The rate dynamics in chemical or physical systems.Electroplating: Coating with a metal or alloy by electrolysis.Cholates: Salts and esters of CHOLIC ACID.Sulfonium Compounds: Sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.Microtechnology: Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.Ethylene Glycols: An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.Furans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Tacrolimus Binding Proteins: A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as FK506) and SIROLIMUS. EC 5.2.1.-

Role of tyrosine and tryptophan in chemically modified serum albumin on its tissue distribution. (1/15)

To investigate the effect of functional groups in bovine serum albumin (BSA) on its tissue distribution characteristics, tyrosine (Tyr) or tryptophan (Trp) residues of BSA were chemically modified by tetranitromethane (TNM) and 2-hydroxy-5-nitrobenzyl bromide (HNB), respectively. BSA was successfully modified with each reagent depending on the amount of the reagent added to the reaction mixture, and TNM- and HNB-modified BSA derivatives with different degrees of modification were obtained. Circular dichroism measurements showed that slight secondary and large tertiary changes were detectable as the degree of modification increased. After intravenous injection into mice, all synthetic BSA derivatives were eliminated very slowly from the systemic circulation. However, (111)In-TNM(6.6)- and (111)In-HNB(2.0)-BSA, derivatives with a high degree of modification, showed a slightly faster disappearance from the systemic circulation and slightly higher accumulation in the liver than (111)In-unmodified BSA. Pharmacokinetic analyses also demonstrated that the modification of Tyr or Trp residues on BSA had only marginal effects on tissue distribution. These results indicate that the Tyr and Trp residues have little effect on the tissue distribution characteristics of serum albumins, and that the specific modification of these residues may be a promising approach to designing sustained drug delivery systems using serum albumins.  (+info)

The role of tryptophanyl residues in heavy meromyosin as studied by chemical modification with 2-hydroxy-5-nitrobenzyl bromide. (2/15)

1. Two moles of 2-hydroxy-5-nitrobenzyl group bound selectively to one mole of heavy meromyosin when it was treated with 2-hydroxy-5-nitrobenzyl bromide, a specific reagent for tryptophanyl residues. The binding with ADP, the size of the initial burst of Pi liberation and the difference absorption spectrum with and without ADP of the bound 2-hydroxy-5-nitrobenzyl groups were measured with heavy meromyosin modified with various amounts of reagent. The properties of the modified heavy meromyosin did not change until the molar binding ratio of the reagent, rH, was about 1, but the properties changed remarkably when rH increased from 1 to 2. 2. Subfragment-1 was prepared from the modified heavy meromyosin by trypsin [EC 3.4.21.4] digestion. The molar binding ratio of the reagent in subfragment-1, rS, was found to be less than 0.1 when rH of the starting heavy meromyosin was less than 0.8. However, rS was about 0.5 in subfragment-1 prepared from heavy meromyosin of rH about 2. The results indicate that only one mole of 2-hydroxy-5-nitrobenzyl group, which was bound with lower reactivity than the other, was bound to a head part of heavy meromyosin. 3. Subfragment-1 fraction prepared from the modified heavy meromyosin could be separated into two fractions by DE-32 cellulose column chromatography; the subfragment-1 portion which eluted later showed a higher rS than that eluted in front. The binding with ADP, the size of the initial burst of Pi liberation and the difference absorption spectrum induced by ATP were measured with the modified subfragment-1 separated by DE-32 cellulose column chromatography. The ADP-binding ability and the size of the initial burst were not dependent on rS, and coincided with those of subfragment-1 prepared from unmodified heavy meromyosin. 4. The results of ADP binding studies suggest that heavy meromyosin is constituted from nonidentical subunits, and that there is an interaction between them which controls the ADP binding. Two tryptophanyl residues having specific reactivity toward 2-hydroxy-5-nitrobenzyl bromide are assumed to be involved in the interaction.  (+info)

Chemical modification and 1H-NMR studies on the receptor-binding region of human interleukin 6. (3/15)

Oxidation of the Met residues of human interleukin 6 (IL-6) molecule has been performed. Reactivity of Met for the oxidation reaction was found to decrease in the order of Met50, Met118, Met185, Met162, and Met68. Chemical modifications involving oxidation and carboxypeptidase A digestion of IL-6 have led to the assignments of the methyl proton resonances of Met162 and Met185, respectively. The hydroxynitrobenzyl chromophore attached to Trp158 in the IL-6 molecule showed a different absorption spectrum when the labeled IL-6 was bound to the soluble IL-6 receptor. This result indicates that Trp158 is near the receptor-binding region in IL-6. On the basis of the 1H-NMR and chemical modification data, it has been concluded that Trp158 is in spatial proximity to Met162, His165 and Met185. The receptor-binding activity decreased with an increase in the number of oxidized Met residues. Of these five Met residues, Met162 was the residue in which the receptor-binding activity decreased in the most parallel degree with that of the oxidation reaction.  (+info)

The preparation and some properties of mammalian cytochrome c modified with 2-hydroxy-5-nitrobenzyl bromide. (4/15)

2-Hydroxy-5-nitrobenzyl bromide reacts with horse heart cytochrome c at acid pH to yield a chemically modified protein. Chromatography of the protein on CM-cellulose allows separation of a single chemically modified species. This species is shown by gel chromatography to be monomeric, and isoelectric focusing shows the pI to be lowered from 10.5 to 9.8 on introduction of the reagent molecule. The changes observed in the u.v. region of the spectrum are consistent with the introduction of a single residue of the reagent, and the normal fluorescence of tryptophan is lost. The chemically modified protein exhibits marked changes in its functional properties as compared with native cytochrome c. Unlike the native monomer, the modified cytochrome c has a pH-dependent spectrum which is typical of a high-spin species in the alpha/beta region at low pH, changing to a low-spin species with an apparent pK of 7.5. The modified protein is autoxidizable and the ferrous form binds CO at neutral pH with an affinity constant of 2.6 X 10(5)M-1. The ferrous form of the modified cytochrome c binds CN- at pH 10.0 with an affinity constant of 3.5 X 10(2)M-1. The modified cytochrome c was incapable of restoring the electron-transfer activity to mitochondria depleted of cytochrome c.  (+info)

Kinetic studies on mammalian cytochrome c modified with 2-hydroxy-5-hydroxy-5-nitrobenzyl bromide. (5/15)

The reduction of 2-hydroxy-5-nitrobenzyl tryptophyl cytochrome c by the chromous ion was studied by stopped-flow techniques. At pH6.5 the reduction of 2-hydroxy-5-nitrobenzyl tryptophyl cytochrome c is complex, showing the presence of three distinct phases. Two chromium concentration-dependent phases are observed (1.1 X 10(5) M-1-S-1, phase 1; 1.25 X 10(4)M-1-S-1, phase 2) and one slow first-order process (0.25S-1, phase 3). A comparison of the static and kinetic difference spectra, along with the data from the reduction of the reoxidized reduced protein, suggests that the slow chromium concentration-independent phase is due to a slow conformational event after fast reduction of the NO2 group. The rates of the chromium concentration-dependent phases show a marked variation with pH above 7.5. The activation energies for the three processes were also measured at 33.2, 38.6 and 69.7 kJ-mol-1 for phases 1, 2 and 3 respectively. The reaction of reduced 2-hydroxy-5-nitrobenzyl tryptophyl cytochrome c with CO was foollowed by means of both stopped-flow and flash photolysis. The combination with CO at pH 6.8 as measured in stopped-flow experiments showed two phases, one CO-dependent phase (phase 2, 2.4 X 10(2)M-1-S-1) and one CO-independent phase (phase 1, 0.015S-1). Investigation of the pH-dependence of the phases showed both the rates and amounts of each phase to be pH-invariant. CO recombination, after photolytic removal, was found to be biphasic; a CO-dependent phase (phase 2, 2.4 X 10(2)M-1-S-1) and a CO-independent phase (phase 1, 1.0s-1) were observed. A tentative model which can accommodate these observations is proposed.  (+info)

Identification of amino acid residues essential for the enzymatic activities of pertussis toxin. (6/15)

The enzymatic ADP-ribosyltransferase activity associated with the S1 subunit of pertussis toxin is considered to be responsible for its biological effects. Although pertussis toxin has no significant homology to other ADP-ribosylating toxins such as diphtheria toxin and Pseudomonas aeruginosa exotoxin A, the results presented in this paper show that, as for diphtheria toxin and exotoxin A, tryptophan and glutamic acid residues are essential for the enzymatic activities of pertussis toxin. Moreover, a structural motif can be identified around the critical glutamic acid residue. Chemical modification or site-directed deletion or replacement of Trp-26 abolishes ADP-ribosyltransferase and the associated NAD glycohydrolase activities. Both enzymatic activities are also abolished when Glu-129 is deleted or replaced by aspartic acid. Mutations at the Glu-106 position do not significantly reduce the enzymatic activities of the S1 subunit. The mutations do not affect the ability of the different S1 forms to be recognized by a variety of monoclonal antibodies, including neutralizing antibodies. Pertussis toxin containing a deletion or replacement of Trp-26, Glu-129, or both in the S1 subunit should thus be devoid of toxic activities without losing its reactivity with protective antibodies and, therefore, could be safely included in new generation vaccines against whooping cough.  (+info)

Chemical modification of a xylanase from a thermotolerant Streptomyces. Evidence for essential tryptophan and cysteine residues at the active site. (7/15)

Extracellular xylanase produced in submerged culture by a thermotolerant Streptomyces T7 growing at 37-50 degrees C was purified to homogeneity by chromatography on DEAE-cellulose and gel filtration on Sephadex G-50. The purified enzyme has an Mr of 20,463 and a pI of 7.8. The pH and temperature optima for the activity were 4.5-5.5 and 60 degrees C respectively. The enzyme retained 100% of its original activity on incubation at pH 5.0 for 6 days at 50 degrees C and for 11 days at 37 degrees C. The Km and Vmax. values, as determined with soluble larch-wood xylan, were 10 mg/ml and 7.6 x 10(3) mumol/min per mg of enzyme respectively. The xylanase was devoid of cellulase activity. It was completely inhibited by Hg2+ (2 x 10(-6) M). The enzyme degraded xylan, producing xylobiose, xylo-oligosaccharides and a small amount of xylose as end products, indicating that it is an endoxylanase. Chemical modification of xylanase with N-bromosuccinimide, 2-hydroxy-5-nitrobenzyl bromide and p-hydroxymercuribenzoate (PHMB) revealed that 1 mol each of tryptophan and cysteine per mol of enzyme were essential for the activity. Xylan completely protected the enzyme from inactivation by the above reagents, suggesting the presence of tryptophan and cysteine at the substrate-binding site. Inactivation of xylanase by PHMB could be restored by cysteine.  (+info)

Chemical modification of the bifunctional human serum pseudocholinesterase. Effect on the pseudocholinesterase and aryl acylamidase activities. (8/15)

The effect of chemical modification on the pseudocholinesterase and aryl acylamidase activities of purified human serum pseudocholinesterase was examined in the absence and presence of butyrylcholine iodide, the substrate of pseudocholinesterase. Modification by 2-hydroxy-5-nitrobenzyl bromide, N-bromosuccinimide, diethylpyrocarbonate and trinitrobenzenesulfonic acid caused a parallel inactivation of both pseudocholinesterase and aryl acylamidase activities that could be prevented by butyrylcholine iodide. With phenylglyoxal and 2,4-pentanedione as modifiers there was a selective activation of pseudocholinesterase alone with no effect on aryl acylamidase. This activation could be prevented by butyrylcholine iodide. N-Ethylmaleimide and p-hydroxy-mercuribenzoate when used for modification did not have any effect on the enzyme activities. The results suggested essential tryptophan, lysine and histidine residues at a common catalytic site for pseudocholinesterase and aryl acylamidase and an arginine residue (or residues) exclusively for pseudocholinesterase. The use of N-acetylimidazole, tetranitromethane and acetic anhydride as modifiers indicated a biphasic change in both pseudocholinesterase and aryl acylamidase activities. At low concentrations of the modifiers a stimulation in activities and at high concentrations an inactivation was observed. Butyrylcholine iodide or propionylcholine chloride selectively protected the inactivation phase without affecting the activation phase. Protection by the substrates at the inactivation phase resulted in not only a reversal of the enzyme inactivation but also an activation. Spectral studies and hydroxylamine treatment showed that tyrosine residues were modified during the activation phase. The results suggested that the modified tyrosine residues responsible for the activation were not involved in the active site of pseudocholinesterase or aryl acylamidase and that they were more amenable for modification in comparison to the residues responsible for inactivation. Two reversible inhibitors of pseudocholinesterase, namely ethopropazine and imipramine, were used as protectors during modification. Unlike the substrate butyrylcholine iodide, these inhibitors could not protect against the inactivation resulting from modification by 2-hydroxy-5-nitrobenzyl bromide, N-bromosuccinimide and trinitrobenzenesulfonic acid. But they could protect against the activation of pseudocholinesterase and aryl acylamidase by low concentrations of N-acetylimidazole and acetic anhydride thereby suggesting that the binding site of these inhibitors involves the non-active-site tyrosine residues.  (+info)

*List of MeSH codes (D02)

... vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455.849.291.850 --- taxoids MeSH D02.455.849.291.850.777 ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH ... 5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH D02.092. ... 2,3-diketogulonic acid MeSH D02.241.081.844.300 --- glucaric acid MeSH D02.241.081.844.322 --- gluconates MeSH D02.241.081.844. ...
Photosensitive protecting reagent for alcohols, acids, phenols etc: J. Am. Chem. Soc., 91, 5694 (1969); J. Org. Chem., 37, 2281, 2285 (1972); Compare 4,5-Dimethoxy-2-nitrobenzyl- alcohol, L00719. Has also been recommended for the protection of the imidazole function in histidine containing peptides: J. Am. Chem. Soc., 97, 440 (1975). See Appendix 6. It has been investigated as a photocleavable protecting group for various N-heterocycles: Tetrahedron Lett., 39, 359 (1998). For reviews of photoremovable groups in organic synthesis, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987). Lee, S. J.; Fowler, J. S.; Alexoff, D.; Schueller, M.; Kim, D.; Nauth, A.; Weber, C.; Kim, S. W.; Hooker, J. M.; Ma, L.; Qu, W. An efficient and practical synthesis of [2-11C]indole via superfast nucleophilic [11C]cyanation and RANEY® Nickel catalyzed reductive cyclization. Org. Biomol. Chem. 2015, 13 (46), 11235-11243.. Bathula, C.; Dangi, P.; Hati, S.; Agarwal, R.; Munshi, P.; Singh, A.; Singh, S.; Sen, S. ...
5-(4-Nitrobenzyl)-[1,3,4]thiadiazol-2-ylamine 247225-84-9 NMR spectrum, 5-(4-Nitrobenzyl)-[1,3,4]thiadiazol-2-ylamine H-NMR spectral analysis, 5-(4-Nitrobenzyl)-[1,3,4]thiadiazol-2-ylamine C-NMR spectral analysis ect.
2-Nitrobenzyl chloride | C7H6ClNO2 | CID 11921 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule n-(4-{hydroxy[(4-nitrobenzyl)oxy]phosphoryl}butanoyl)glycine (C13H17N2O8P) from the PQR.
Until recently, crystallographic studies of P450 2B enzymes were mainly focused on rabbit 2B4 because of its optimal solubility and stability during purification and crystallization. A series of crystal structures of 2B4 identified the active site residues that are involved in substrate recognition and ligand binding. In the closed structures of 2B4 in complex with 4-CPI and 1-CPI, residues contacting the ligand include Ile101, Val104, Ile114, Phe115, Phe206, Ile209, Phe297, Ala298, Glu301, Thr302, Ile362, Val367, and Val477, which are mainly hydrophobic except for Glu301 and Thr302 (Scott et al., 2004; Zhao et al., 2007). The corresponding residues in the active site of 2B6 deduced from the 4-CPI complex were essentially the same, with the only substitution occurring at residue 363, which is Ile in 2B4 and Leu in 2B6. In addition, the structure of 2B6 in complex with 4-CPI revealed similarities in the orientations of side chains involved in binding the inhibitor compared with the 2B4-4-CPI ...
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Guzei IA, Spencer LC, Lin Q, Blackwell HE. N-{(Aminocarbonyl) (S)-4-nitrobenzyl methyl}-N-{ (R)-cyclohexyl (cyclohe xylaminocarbonyl)methyl}propanamide methanol solvate. Acta Crystallographica Section E-Structure Reports Online. 2007 ;63:O1892-O1894. ...
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8-[(4-methoxy-3-nitrobenzyl)sulfanyl]quinoline | C17H14N2O3S | CID 671541 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
D.V.Carter; P.T.Charlton; A.H.Fenton; J.R.Housley; B.Lessel. The preparation and the antibacterial and antifungal properties of some substituted benzyl alcohols. Journal of Pharmacy and Pharmacology. 1958, 10,(S1), 149T-159T.. J.Meuche-Albeny; P.Rathelot; M.P.Crozet; P.Vanelle. S RN1 reactions in the nitrobenzo[1,3]dioxole series. Chemistry of Heterocyclic Compounds. 2003, 39,(8), 989-997.. ...
Synthesis, purification, and characterization of 3′‐O‐caged 2′‐deoxyribonucleoside triphosphates (dNTPs), namely 3′‐O‐(2‐nitrobenzyl)‐2′‐deoxy ribonucleoside triphosphates (NB‐dNTPs) and 3′‐O‐(4,5‐dimethoxy‐2‐nitrobenzyl)‐2′‐deoxy ribonucleoside triphosphates (DMNB‐dNTPs), are discussed in detail
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Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Contents may develop pressure upon prolonged storage. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Handle under an inert atmosphere. Use only in a chemical fume hood. Prevent build up of vapors to explosive concentration. Keep from contact with moist air and steam. Do not breathe dust or fumes ...
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The reactions of ( E)-cyclooctene with N-bromosuccinimide in the presence of water or methanol are described. Major products of the hydroxybromination are trans-4-bromocyclooctanol as a product of...
Pseudocholinesterase deficiency is an inherited blood plasma enzyme abnormality in which the bodys production of butyrylcholinesterase (BCHE; pseudocholinesterase) is impaired. People who have this abnormality may be sensitive to certain anesthetic drugs, including the muscle relaxants succinylcholine and mivacurium as well as other ester local anesthetics. Multiple studies done both in and outside India have shown an increased prevalence of pseudocholinesterase deficiency amongst the Arya Vysya community. A study performed in the Indian State of Tamil Nadu in Coimbatore, on 22 men and women from this community showed that 9 of them had pseudocholinesterase deficiency, which translates to a prevalence that is 4000-fold higher than that in European and American populations. Pseudocholinesterase deficiency (anesthesia sensitivity) is an autosomal recessive condition common within the Persian and Iraqi Jewish populations. Approximately one in 10 Persian Jews are known to have a mutation in the ...
PCHES : Monitoring exposure to organophosphorus insecticides Monitoring patients with liver disease, particularly those undergoing liver transplantation Identifying patients who are homozygous or heterozygous for an atypical gene and have low levels of pseudocholinesterase
Pseudocholinesterase deficiency is a rare genetic condition where the affected individual has increased sensitivity to several anesthetic agents. The use of these drugs may leave some of the muscles paralyzed
K.M. KUTTY, V. ANNAPURNA, V. PRABHAKARAN; Pseudocholinesterase: a protein with functions unrelated to its name. Biochem Soc Trans 1 June 1989; 17 (3): 555-556. doi: https://doi.org/10.1042/bst0170555. Download citation file:. ...
An indicator for detecting residual ethylene oxide comprising a substrate impregnated with a solution of 4-(4-nitrobenzyl)pyridine and an envelope of the substrate which is at least partially transparent and has low permeability to gaseous ethylene oxide is provided, the envelope being preferably made of a transparent plastic film. With the indicator, an amount of ethylene oxide remaining in various medical instruments, etc. may be estimated by the naked eye since the color of the indicator changes step by step in the course of the release of residual ethylene oxide.
IV onset in 30s to 1 minute, lasting 2-3 minutes, with offset typically within 10 minutes. Offset occurs due to dissociation of drug out of NMJ into plasma, as a concentration gradient is established by drug breakdown in plasma. Prolonged duration in patients with pseudocholinesterase deficiency. IM onset in 2-3 minues ...
This study aims to investigate the variation of pseudocholinesterase activity (BuChE) in bipolar patients and to explore its relation to the clinical and therapeutic characteristics of this disease. Our study included 105 patients with bipolar disorder and 100 control subjects aged 38.7 ± 12.2 and 36.4 ± 15.7 y, respectively. BuChE was determined by kinetic methods on Cobas Integra 400 plus™. Compared with controls, patients had a significantly higher pseudocholinesterase activity. Moreover, this increase was significantly associated (p = 0.001) with bipolar disorder with sensibility of 58% and specificity of 62% at threshold of 7392 IU/L. There was no significant change in pseudocholinesterase activity in relation to illness episodes and treatment, whereas the lowest values of this activity were seen in euthymic patients and those taking psychotics. Therefore, this activity is a real interest in the biological monitoring of patients as a risk factor for neurodegenerative diseases associated ...
2016 N-Bromosuccinimide (CAS 128-08-5) Industry Market Report is a market research report available at US $2800 for a Single User PDF License from RnR Market Research Reports Library.
The catalytic asymmetric bromoamination of chalcones with N-bromosuccinimide as both bromine and amide source was realized by using a chiral N,N′-dioxide-Sc(NTf2)3 complex as an efficient catalyst. The corresponding chiral bromoamination products were obtained in high yields with high dr and good ee values (
Description: Alkenes treated with N-bromosuccinimde (NBS) and water will form bromohydrins. [private_ReactionGuide] Notes: The reaction is Markovnikoff selective and provides the trans-product. NBS stands for N-bromosuccinimide, it looks like this: Examples: Notes: Note how in examples 1
... is an oral anticoagulant of the coumarin series, synthesized and developed in the Geigy laboratoires in the late 1960s and sold in the United States under the brand name of Sintrom. It lowers the prothrombin level of the blood. It is a white crystalline powder without taste and odor and has a molecular weight of 353. It is soluble in alkaline solutions but only slightly soluble in water and organic solvents. Chemically, acenocoumarol is 3-(alpha-acetonyl-4-nitrobenzyl)-4-hydroxycoumarin. ...
Thank you for your interest in spreading the word about The BMJ.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
The thesis describes the synthesis of new analogues (53-57) of PBG and their inhibition of and mechanistic studies on the enzyme PBG deaminase from E. coli. The analogues with an additional alkyl group, 53 and 54, were successfully obtained in good yields in 10 steps. The caged compound 97 was also obtained but the final step of hydrogenolysis of the benzyl protecting groups also caused reduction of the nitro group on the 2-nitrobenzyl substituent. Testing of analogues 53 and 54 with the enzyme (PBGD), however, showed no inhibition. A new route for the synthesis of the conformationally restricted analogue 6, 11-ethanoPBG 56 was developed in this work and one stereoisomer of 56 was obtained (the cis-isomer). When this analogue was tested as an inhibitor it also showed no inhibition. This was thought to be due to the stereochemistry of the compound since modelling studies had predicted that the trans-isomer would bind tightly to the enzyme not the cis-isomer. Therefore, the ...
315.0 Kg o-Nitrotoluene was mixed with 1000 Lit Monochlorobenzene. To this mixture 275.0 Kg 3,5- Dibromo dimethylhydantoin & 26.0 Kg Azoisobutyronitrile (AIBN) was charged. The reaction mixture was digested for 10 hr at 60°C. After cooling, sodium carbonate solution (10%) charged to adjust pH 9.5. 175.0 Kg N-methylcyclohexylamine was added to the reaction mixture and the reaction mixture was digested for 8 hr at 85°C. Organic and aqueous layers were separated. Organic layer was charged with dilute hydrochloric acid solution. Monocholorobenzene layer was separated after complete formation of hydrochloride salt of the product. The aqueous acidic layer was then basified with caustic lye to yield 350.0 Kg of N-(2-nitrobenzyl)-N-methylcyclohexylamine of formula II. Organic layer was steam distilled to recover Monochlorobenzene, which is recycled in next batch ...
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1NR6: Structure of Mammalian Cytochrome P450 2C5 Complexed with Diclofenac at 2.1 A Resolution: Evidence for an Induced Fit Model of Substrate Binding
CHED : Serum cholinesterase, often called pseudocholinesterase (PCHE), is distinguished from acetylcholinesterase or "true cholinesterase," by both location and substrate.   Acetylcholinesterase is found in erythrocytes, in the lungs and spleen, in nerve endings, and in the gray matter of the brain. It is responsible for the hydrolysis of acetylcholine released at the nerve endings to mediate transmission of the neural impulse across the synapse.   PCHE, the serum enzyme, is also found in liver, pancreas, heart, and white matter. Its biological role is unknown.   The organophosphorus-containing insecticides are potent inhibitors of the true cholinesterase and cause depression of PCHE. Low values of PCHE are also found in patients with liver disease. In general, patients with acute hepatitis and chronic hepatitis of long duration will show a 30% to 50% decrease in PCHE values, while patients with advanced cirrhosis and carcinoma with metastases will show a 50% to 70%
Global N-Bromosuccinimide Market Research Report 2017 is a market research report available at US $2900 for a Single User PDF License from RnR Market Research Reports Library.
A simple, sensitive and rapid spectrophotometric method has been developed for the determination of aripiprazole in pharmaceutical formulations. The proposed method is based on the..
7-Benzyl-3- tert -butyl-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C22H25N3O, (I), and 3- tert -butyl-7-(4-methylbenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H27N3O, (II), are isomorphous in the space group P21, and molecules are linked into chains by C,H...O hydrogen bonds. In each of 3- tert -butyl-7-(4-methoxybenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H27N3O2, (III), which has cell dimensions rather similar to those of (I) and (II), also in P21, and 3- tert -butyl-1-phenyl-7-[4-(trifluoromethyl)benzyl]-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H24F3N3O, (IV), there are no direction-specific interactions between the molecules. In 3- tert -butyl-7-(4-nitrobenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C22H24N4O3, (V), a combination of C,H...O and C,H...N hydrogen bonds links the molecules into complex sheets. There are no direction-specific interactions between the molecules of 3- tert ...
see article for more examples. Abstract. Unsaturated compounds such as alkenes, alkynes, allenes, and methylenecyclopropanes (MCPs) can be dibrominated within minutes by NBS and lithium bromide in THF at room temperature in good to excellent yields under mild conditions.. ...

Discovery and pharmacological studies of 4-hydroxyphenyl-derived phosphonium salts active in a mouse model of visceral...Discovery and pharmacological studies of 4-hydroxyphenyl-derived phosphonium salts active in a mouse model of visceral...

... triphenylphosphonium bromide] in a mouse model of visceral leishmaniasis were established. Compound 1 reduced the parasite load ... 2-hydroxy-5-nitrobenzyl Bromide. A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein ... A readily available quaternary phosphonium salt containing a trifluoroacetonyl group and a tetrakis[3,5-bis(trifluoromethyl) ... The pharmacokinetics and in vivo oral efficacy of compound 1 [(16-(2,4-dihydroxyphenyl)-16-oxohexadecyl) ...
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Leicester Research Archive: Studies on Escherichia coli citrate synthase.Leicester Research Archive: Studies on Escherichia coli citrate synthase.

Modification with 2-hydroxy-5-nitrobenzyl bromide also indicated the participation of tryptophan in the activity of the enzyme ... preliminary kinetic studies indicated that the activation of citrate synthase by KCl is the result of an approximately 5-fold ...
more infohttps://lra.le.ac.uk/handle/2381/35201

Time-Resolved Fluorescence | SpringerLinkTime-Resolved Fluorescence | SpringerLink

2.Istituto di Tecniche Spettroscopiche CNR MessinaMessinaItaly. *3.Istituto di Chimica Farmaceutica e TossicologicaUniversità ... 2-hydroxy-5-nitrobenzyl bromide, J. Am. Chem. Soc. 87: 1126CrossRefGoogle Scholar ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4613-0381-7_117

PHENOL, 5-(3,4-DIHYDRO-5,6,7-TRIMETHOXY-1-NAPHTHALENYL)-2-METHOXY-,PHENOL, 5-(3,4-DIHYDRO-6,7,8-TRIMETHOXY-1-NAPHTHALENYL)-2...PHENOL, 5-(3,4-DIHYDRO-5,6,7-TRIMETHOXY-1-NAPHTHALENYL)-2-METHOXY-,PHENOL, 5-(3,4-DIHYDRO-6,7,8-TRIMETHOXY-1-NAPHTHALENYL)-2...

5-(3,4-DIHYDRO-5,6,7-TRIMETHOXY-1-NAPHTHALENYL)-2-METHOXY-,PHENOL, 5-(3,4-DIHYDRO-6,7,8-TRIMETHOXY-1-NAPHTHALENYL)-2-METHOXY- ... 3-HYDROXY-4-NITROBENZYL BROMIDE Molecular Formula: C7H6BrNO3. Molecular Weight: 232.031440 [g/mol]. ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 1 2 3 4 5 * ... C20H22O5. Molecular Weight: 342.385680 [g/mol]. H-Bond Donor: 1 ... 111394-51-5. Phenol, 5-(bromomethyl)-2-nitro- (2 suppliers). IUPAC Name: 5-(bromomethyl)-2-nitrophenol , CAS Registry Number: ...
more infohttps://www.chemicalregister.com/Companies/AName/Page425/aidP.htm

List of MeSH codes (D02) - WikipediaList of MeSH codes (D02) - Wikipedia

... vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455.849.291.850 --- taxoids MeSH D02.455.849.291.850.777 ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH ... 5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH D02.092. ... 2,3-diketogulonic acid MeSH D02.241.081.844.300 --- glucaric acid MeSH D02.241.081.844.322 --- gluconates MeSH D02.241.081.844. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

WO1983001064A1 - Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems 
        - Google...WO1983001064A1 - Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems - Google...

Cited By (2). * Cited by examiner, † Cited by third party. Publication number. Priority date. Publication date. Assignee. Title ... 5 ml of the colored eluate was recovered in 4 tubes.. 5 mg of Congo Red in one ml of distilled water and 4 mg of carbodiimide ... Citations (5). * Cited by examiner, † Cited by third party. Publication number. Priority date. Publication date. Assignee. ... Family Cites Families (5). * Cited by examiner, † Cited by third party. Publication number. Priority date. Publication date. ...
more infohttps://patents.google.com/patent/WO1983001064A1/en

Indian Patents. 258215:AN ISOLATED PEPTIDE FOR ACTIVATING PROINSULIN OR INSULIN SENSITIVE CD4+ T-CELLSIndian Patents. 258215:AN ISOLATED PEPTIDE FOR ACTIVATING PROINSULIN OR INSULIN SENSITIVE CD4+ T-CELLS

hydroxy-5-phenylpentanoic acid, 6-aminohexanoic acid, t-butylglycine. nonailine,. phenylglycine, ornithine, sarcosine, 4-amino ... chemical cleavage (e.g. cyanogen bromide). The peptides can also be synthesized by. expression of overlapping nucleic acid ... 5. The isolated peptide of Claim 1 or .2 or 3 wherein the T-cell epitqpe is on the Achain. of the proinsulin or insulin.. 6. ... T-cell clones (5 x. lO4 cells/well) were cultured in the presence of irradiated autologous PBMC (5 x 104/weH). and each peptide ...
more infohttp://www.allindianpatents.com/patents/258215-an-isolated-peptide-for-activating-proinsulin-or-insulin-sensitive-cd4-t-cells

MODIFIED SURFACE ANTIGEN - Patent applicationMODIFIED SURFACE ANTIGEN - Patent application

... bromides and sulfates, organic acids such as acetates, propionates and malonates and pyrogen-free water. [0231] A useful ... 4-amino-3-hydroxy-5-phenylpentanoic acid, 4-amino-3-hydroxy-6-methylheptanoic acid, t-butylglycine, norleucine, norvaline, ... 0336] HOMP5: 5-CAA TTA ACG GCC GAA TAA AAG GAA GCC GAT ATG AAC AAA ATA TAC CGC ATC-3 (SEQ ID NO:40); [0337] SO-G: 5-CAG CGA ... 2 (SEQ ID NOS: 12-22). EXAMPLE 2 [0274] PMC 21 NhhA Polypeptide Over-Expression [0275] The NhhA protein encoded by the nhhA ...
more infohttp://www.patentsencyclopedia.com/app/20130136762

Adsorption-Induced Changes in Enzyme Bioactivity Correlated with Adsor by Kenan Fears"Adsorption-Induced Changes in Enzyme Bioactivity Correlated with Adsor" by Kenan Fears

... sulfonium bromide (DHNBS), which selectively labels solvent accessible tryptophan residues. Analysis of tryptophans labeled ... sulfonium bromide (DHNBS), which selectively labels solvent accessible tryptophan residues. Analysis of tryptophans labeled ... NH2-, and COOH-terminated alkanethiol self-assembled monolayer (SAM) surfaces. The bioactivities of the small proteins, TRP, ...
more infohttps://tigerprints.clemson.edu/all_dissertations/338/

Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation and...Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation and...

3-(4-hydroxy benzoyl) 2-ethyl 1-methyl 4-nitro indole M.p.: 191° C. (water/acetic acid 7/3) d) 3-[4-(3-di-n-butylamino-propoxy) ... bromide and 120.2 g (1.52 mole) of pyridine in 700 ml of chloroform. The mixture is heated at reflux for 2 hours. 2800 ml of ... NH2 n-C4 H9. n-C4 H9. n-C4 H9. 10 53. CH3 SO2 -- n-C4 H9. n-C4 H9. n-C4 H9. 10 66. ##STR114## n-C4 H9. n-C4 H9. n-C4 H9. 10 23 ... In this manner, 9.3 g of 3-(4-hydroxy benzoyl) 2-n-butyl 1-methyl 5-nitro indole are obtained. ...
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2-hydroxy-dATP diphosphatase | definition of 2-hydroxy-dATP diphosphatase by Medical dictionary2-hydroxy-dATP diphosphatase | definition of 2-hydroxy-dATP diphosphatase by Medical dictionary

What is 2-hydroxy-dATP diphosphatase? Meaning of 2-hydroxy-dATP diphosphatase medical term. What does 2-hydroxy-dATP ... Looking for online definition of 2-hydroxy-dATP diphosphatase in the Medical Dictionary? 2-hydroxy-dATP diphosphatase ... redirected from 2-hydroxy-dATP diphosphatase) NUDT1. A gene on chromosome 7p22 that encodes an antimutagenic enzyme which ... medical-dictionary.thefreedictionary.com/2-hydroxy-dATP+diphosphatase,NUDT1,/a,. *Facebook ...
more infohttps://medical-dictionary.thefreedictionary.com/2-hydroxy-dATP+diphosphatase

Archerchem --  Intermediates ListArcherchem -- Intermediates List

4-{4-(Dimethyl amino} propyl} -1- (4- fluorophenyl )-1,hydroxy butyl- 3(-(hydroxy methyl). ... P-Nitrobenzyl (4R,5S,6S)-3-(diphenyloxy)phosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2- ... 1R,2S,5R)-Menthyl- (2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic ... 4-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate. ...
more infohttp://archerchem.com/Intermediates.php

Application # 2018/0251517. NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY
     AGAINST VARIOUS TUMORS -...Application # 2018/0251517. NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS -...

Histidine can also be modified using 4-hydroxy-2-nonenal. The reaction of lysine residues and other .alpha.-amino groups is, ... Position 1 2 3 4 5 6 7 8 9 SEQ ID NO. 4 V L F G E L P A L Variants V I A M V M I M M A A V A I A A A V V V I V V A T V T I T T ... 2. The method of claim 1, wherein the T cells are autologous to the patient. 3. The method of claim 1, wherein the T cells are ... 5 1879PRTHomo sapiens 187Ser Ile Leu Lys Glu Asp Pro Phe Leu 1 5 1889PRTHomo sapiens 188Val Leu Gly Glu Glu Gln Glu Gly Val 1 5 ...
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MODIFIED SURFACE ANTIGEN - Patent applicationMODIFIED SURFACE ANTIGEN - Patent application

... bromides and sulfates, organic acids such as acetates, propionates and malonates and pyrogen-free water. [0226]A useful ... 4-amino-3-hydroxy-5-phenylpentanoic acid, 4-amino-3-hydroxy-6-methylheptanoic acid, t-butylglycine, norleucine, norvaline, ... 2 (SEQ ID NOS:12-22). EXAMPLE 2 PMC 21 NhhA Polypeptide Over-Expression [0264]The NhhA protein encoded by the nhhA gene of N. ... dimethyldioctadecylammonium bromide, N,N-dicoctadecyl-N, Nbis(2-hydroxyethyl-propanediamine), methoxyhexadecylglycerol, and ...
more infohttp://www.patentsencyclopedia.com/app/20090068216

6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids - Patent # 4683226 - PatentGenius6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids - Patent # 4683226 - PatentGenius

6-substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids and cogeners having useful antibacterial activity are ... The compounds are prepared in a reaction sequence starting with a 4-acyloxy-2-azetidinone. ... The chloride or bromide of formula XII is then reacted with a suitable phosphine, e.g., tri-p-methoxyphenyl phosphine, ... Suitable hydroxy protecting groups are those such as 2,2,2-trichloroethoxycarbonyl, 1,1,1-trichloro-2-methyl-2-propoxycarbonyl ...
more infohttp://www.patentgenius.com/patent/4683226.html

2-Hydroxyethyl stearate | definition of 2-Hydroxyethyl stearate by Medical dictionary2-Hydroxyethyl stearate | definition of 2-Hydroxyethyl stearate by Medical dictionary

What is 2-Hydroxyethyl stearate? Meaning of 2-Hydroxyethyl stearate medical term. What does 2-Hydroxyethyl stearate mean? ... Looking for online definition of 2-Hydroxyethyl stearate in the Medical Dictionary? 2-Hydroxyethyl stearate explanation free. ... 25-hydroxy-vitamin D. *2-acetylaminofluorine. *2-aminoethanesulfonic acid. *2-azetidinecarboxylic acid ... redirected from 2-Hydroxyethyl stearate). Also found in: Dictionary, Thesaurus, Encyclopedia. stearic acid. [ste-ar´ik] a ...
more infohttps://medical-dictionary.thefreedictionary.com/2-Hydroxyethyl+stearate

4 methoxy benzyl alcohol suppliers in hyderabad4 methoxy benzyl alcohol suppliers in hyderabad

Hydroxy Butane Sulphonic Acid Potassium Salt 4-Chloro Butyraldehyde Diethyl Acetal Para Nitro Benzyl Bromide Para Nitro Benzyl ... Chemical Companies - O Hydroxy Benzyl Alcohol, Service .. List of chemical companies, o hydroxy benzyl alcohol Companies ... S.NO INTERMEDIATES CAS NO API; 1 (1S,4R)-(4-Aminocyclopent-2-enyl) Methanol Hydrochloride: 168960-19-8: Abacavir: 2 (1S,4R)-4-( ... Products supplying, 1, 4-dioxane n, n..bis ( 2-chloro ethyl ) amine hcl acetyl chloride, ammonium sulphate, bromine liquid, ...
more infohttps://steunmijnclub.nl/2596_4-methoxy-benzyl-alcohol-suppliers-in-hyderabad.html

2-hr PC | Article about 2-hr PC by The Free Dictionary2-hr PC | Article about 2-hr PC by The Free Dictionary

Looking for 2-hr PC? Find out information about 2-hr PC. or monosaccharide sugar with the empirical formula C6H12O6 . This ... carbohydrate carbohydrate, any member of a large class of chemical compounds that includes... Explanation of 2-hr PC ... redirected from 2-hr PC). Also found in: Dictionary, Thesaurus, Medical. glucose,. dextrose,. or grape sugar,. monosaccharide ... The complete enzymatic oxidation of glucose to CO2 and H2O is accompanied by the release of energy: C6H12O6 + 602-6CO2 + 6H2O ...
more infohttps://encyclopedia2.thefreedictionary.com/2-hr+PC

US Patent # 4,119,717. 16-S-acyl derivatives of fusidic acid - Patents.comUS Patent # 4,119,717. 16-S-acyl derivatives of fusidic acid - Patents.com

C. to a stirred solution of sodium bromide (3.09 g; 30 mmol) and 16-epideacetylfusidic acid acetoxymethyl ester (1.73 g; 5 mmol ... Z being a hydroxy group, a halogen atom, a methylsulfonyloxy or p-tolylsulfonyloxy group, an azido or a nitro group, Q.sub.2 is ... p-nitrobenzyl or p-methoxybenzyl. The reactions are performed in an inert organic solvent, e.g. dimethylformamide, and at ... Phenyl N,N-dimethylformamide bromide was prepared by dropwise addition of phenyl chloroformate (6.5 ml; 50 mmol) to a stirred ...
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US7708396B2 - Photochromic phase change inks 
        - Google PatentsUS7708396B2 - Photochromic phase change inks - Google Patents

... bromide, iodide, and astatide, amine groups, including primary, secondary, and tertiary amines, hydroxy groups, alkoxy groups, ... o-nitrobenzyl derivatives, spiro compounds, and the like, and in inorganic compounds, such as metal oxides, alkaline earth ... bromide, iodide, and astatide, amine groups, including primary, secondary, and tertiary amines, hydroxy groups, alkoxy groups, ... bromide, iodide, and astatide, amine groups, including primary, secondary, and tertiary amines, hydroxy groups, alkoxy groups, ...
more infohttps://patents.google.com/patent/US7708396?oq=7%2C403%2C220

Cephalosporins - Patent # 5621095 - PatentGeniusCephalosporins - Patent # 5621095 - PatentGenius

When Y is hydroxy, the product is also converted into a product in which Y is iodine for example by the action of tetrabutyl ... An example of the halide is chloride or the bromide.. The anhydride can be formed in situ by the action of N,N-disubstituted ... 4-nitrobenzyl, phenethyl, trityl, diphenylmethyl and3,4-dimethoxyphenyl. Phenyl, 4-chloro phenyl, tolyl and tert-butylphenyl ... One of the,reagents indicated above can also be reacted with a product of formula IV in which the hydroxy has been converted ...
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2-Hydroxyethyl stearate | Article about 2-Hydroxyethyl stearate by The Free Dictionary2-Hydroxyethyl stearate | Article about 2-Hydroxyethyl stearate by The Free Dictionary

Looking for 2-Hydroxyethyl stearate? Find out information about 2-Hydroxyethyl stearate. CH3 16COOH Natures most common fatty ... redirected from 2-Hydroxyethyl stearate). Also found in: Dictionary, Thesaurus, Medical. stearic acid. [′stir·ik ′as·əd] ( ... also n-octadecanoic acid), CH3(CH2)16COOH, a monobasic saturated aliphatic carboxylic acid. The acid takes the form of ... CH3(CH2)16COOH Natures most common fatty acid, derived from natural animal and vegetable fats; colorless, waxlike solid, ...
more infohttps://encyclopedia2.thefreedictionary.com/2-Hydroxyethyl+stearate

Immunosuppressive compounds - Vertex Pharmaceuticals, Inc.Immunosuppressive compounds - Vertex Pharmaceuticals, Inc.

... bromides and iodides, aralkyl halides like benzyl and phenethyl bromides and others. Water or oil-soluble or dispersible ... E-3-(4-Hydroxy-. Phenyl 2 ND ND. phenyl)-2-. methyl-prop-. 2-enyl. 4 E-3-[cis-(4-. Phenyl 2 ND ND. hydroxycyclo-. hexyl)]-2- ... E-3-(4-Hydroxy-. Methoxy 2 ND ND. phenyl)-2-methyl-. prop-2-enyl. E-3-[cis-(4-. Methoxy 2 70 μM. ,20 μM. Hydroxycyclo-. hexyl ... bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl and diamyl sulfates, long chain halides such as decyl, ...
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Patent US7759044 - Low activation energy dissolution modification agents for photoresist ... - Google PatentsPatent US7759044 - Low activation energy dissolution modification agents for photoresist ... - Google Patents

... a hydroxy substituted alkylene having 1 to 12 carbon atoms, a hydroxy substituted fluoroalkylene having 1 to 12 carbon atoms, a ... nitrobenzyl sulfonate esters, 2-nitrobenzyl p-toluenesulfonate, 2,6-dinitrobenzyl p-toluenesulfonate, 2,4-dinitrobenzyl p- ... triphenylsulfonium bromide, triphenylsulfonium chloride, triphenylsulfonium iodide, 2,4,6-trimethylphenyldiphenylsulfonium ... wherein each P1, P2, P3, P4, P5, P6, P7, P8, P9, P10, P11, P12, P13, P14, and P15 is independently selected from the group ...
more infohttp://www.google.com/patents/US7759044?dq=6377161

3′‐O‐Caged 2′‐Deoxynucleoside Triphosphates for Light‐Mediated, Enzyme‐Catalyzed, Template‐Independent DNA Synthesis - Current...3′‐O‐Caged 2′‐Deoxynucleoside Triphosphates for Light‐Mediated, Enzyme‐Catalyzed, Template‐Independent DNA Synthesis - Current...

... nitrobenzyl)‐2′‐deoxy ribonucleoside triphosphates (NB‐dNTPs) and 3′‐O‐(4,5‐dimethoxy‐2nitrobenzyl)‐2′‐deoxy ribonucleoside ... Synthesis, purification, and characterization of 3′‐O‐caged 2′‐deoxyribonucleoside triphosphates (dNTPs), namely 3′‐O‐(2‐ ... Nitrobenzyl bromide (Sigma‐Aldrich, cat. no. SKU: 107794)Saturated sodium bicarbonate (NaHCO 3) ... hydroxy2′‐deoxyribofuranosyl]‐6‐chloropurine (Berry & Associates, cat. no.PR3370) ...
more infohttp://www.currentprotocols.com/WileyCDA/CPUnit/refId-nc1317.html
  • A readily available quaternary phosphonium salt containing a trifluoroacetonyl group and a tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (BAr) counterion was demonstrated to be a highly active Brøns. (bioportfolio.com)
  • provided that when n=1 then D is a group other than phenyl and B is a group other than benzyl, and when n=2 then B is into methyl or t-butyl. (freepatentsonline.com)
  • A seven membered chelate ring complex of Mn(II) derived from bis(5-phenyl-2H-1,2,4-triazole)-3-yl-disulfane and cleavage of the S-S bond in a Co(II) complex: Synthesis, spectral and structural characterization. (howard.edu)
  • 3-[2-(6-Bromo-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)ethyl]-1, 3-oxazolidin-2-one. (howard.edu)
  • Finally, preliminary kinetic studies indicated that the activation of citrate synthase by KCl is the result of an approximately 5-fold reduction in the Km for acetyl-CoA. (le.ac.uk)
  • Heterocycles of 5 or 6 ring members that P and P' can form with the nitrogen atom to which they are linked may be piperidine, morpholine, pyrrolidine. (patentgenius.com)
  • The invention relates to a new process for the preparation of (l'-tert-buto^carbonyl-2-oxo-[l,3l]-bipyrrolidinyl-3-(R)S)»yl)-triphenyl-phosphonium halogenide compounds of formula I wherein * signifies an asymmetric center with an (R) or (S) configuration and X represents chlorine, bromine or iodine. (allindianpatents.com)
  • 23056-33-9 2-Chloro-4-methylbenzotrifluoride 74483-46-8 2-chloro-4-methylpyridine 3678-62-4 2-Chloro-4-nitropyridine 23056-36-2 2-Chloro-4-picoline 3678-62-4 2-Chloro-4-trifluoromethylpyridine 81565-18-6 2-Chloro-5-aminomethyl-pyridine 97004-04-1 2-chloro-5-aminopyridine 5350-93-6. (twfta.com)
  • 2. A compound according to claim 1, in which Q.sub.1 stands for the grouping ##STR36## Z having the meaning defined in claim 1. (patents.com)
  • 5. A compound according to claim 1, in which Q.sub.2 stands for oxygen. (patents.com)
  • 2) by using synthetic peptides identical to the sequence of proinsuliivtp recall T-cell proliferation responses from peripheral blr. (allindianpatents.com)
  • The compounds of formula I are known from EP-A 0 849 269 and can be obtained through multiple-step synthesis of the corresponding allyloxycarbonyl (ALLOC) protected [l,3']bipyrrolidinyl-2-oxo derivative by removal of the allyloxycarbonyl protecting group and protection reaction with a tert-butoxycarbonyl moiety to yield tert-butoxycarbonyl (t-BOC) protected [l,3,]bipyrrolidinyl-2-oxo compounds of formula I. (allindianpatents.com)
  • The compounds are prepared in a reaction sequence starting with a 4-acyloxy-2-azetidinone. (patentgenius.com)
  • Acta Crystallographica Section E: Structure Reports Online, Vol.67, No.5 (2011): o1283-o1284. (howard.edu)