2-Hydroxy-5-nitrobenzyl Bromide: A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules. Used for 'active site' enzyme studies and other protein studies. Sometimes referred to as Koshland's reagent.Bromosuccinimide: A brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations. (From Miall's Dictionary of Chemistry, 5th ed; Hawley's Condensed Chemical Dictionary, 12th ed,).Thioinosine: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Fluorescence Polarization: Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.Fluoroimmunoassay: The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.Fluorescence: The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.Europium: Europium. An element of the rare earth family of metals. It has the atomic symbol Eu, atomic number 63, and atomic weight 152. Europium is used in the form of its salts as coatings for cathode ray tubes and in the form of its organic derivatives as shift reagents in NMR spectroscopy.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Xeroderma Pigmentosum Group D Protein: A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCLEOTIDE EXCISION REPAIR, and mutations in this protein are associated with XERODERMA PIGMENTOSUM.Aldehyde Dehydrogenase: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.IndolizinesNitrogen Compounds: Inorganic compounds that contain nitrogen as an integral part of the molecule.ThiophenesHeterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.PC12 Cells: A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.Peptide Elongation Factor G: Peptide Elongation Factor G catalyzes the translocation of peptidyl-tRNA from the A to the P site of bacterial ribosomes by a process linked to hydrolysis of GTP to GDP.Impetigo: A common superficial bacterial infection caused by STAPHYLOCOCCUS AUREUS or group A beta-hemolytic streptococci. Characteristics include pustular lesions that rupture and discharge a thin, amber-colored fluid that dries and forms a crust. This condition is commonly located on the face, especially about the mouth and nose.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Thiolester HydrolasesStaphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Electroplating: Coating with a metal or alloy by electrolysis.Cholates: Salts and esters of CHOLIC ACID.Sulfonium Compounds: Sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.Microtechnology: Manufacturing technology for making microscopic devices in the micrometer range (typically 1-100 micrometers), such as integrated circuits or MEMS. The process usually involves replication and parallel fabrication of hundreds or millions of identical structures using various thin film deposition techniques and carried out in environmentally-controlled clean rooms.Ethylene Glycols: An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.Furans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Deoxyribonucleotides: A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.Ribonucleotides: Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)Deoxycytosine Nucleotides: Cytosine nucleotides which contain deoxyribose as the sugar moiety.Deoxyribonucleosides: A purine or pyrimidine base bonded to DEOXYRIBOSE.Templates, Genetic: Macromolecular molds for the synthesis of complementary macromolecules, as in DNA REPLICATION; GENETIC TRANSCRIPTION of DNA to RNA, and GENETIC TRANSLATION of RNA into POLYPEPTIDES.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Benzyl CompoundsTextbooks as Topic: Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)Asparaginase: A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.Toluene: A widely used industrial solvent.

Role of tyrosine and tryptophan in chemically modified serum albumin on its tissue distribution. (1/15)

To investigate the effect of functional groups in bovine serum albumin (BSA) on its tissue distribution characteristics, tyrosine (Tyr) or tryptophan (Trp) residues of BSA were chemically modified by tetranitromethane (TNM) and 2-hydroxy-5-nitrobenzyl bromide (HNB), respectively. BSA was successfully modified with each reagent depending on the amount of the reagent added to the reaction mixture, and TNM- and HNB-modified BSA derivatives with different degrees of modification were obtained. Circular dichroism measurements showed that slight secondary and large tertiary changes were detectable as the degree of modification increased. After intravenous injection into mice, all synthetic BSA derivatives were eliminated very slowly from the systemic circulation. However, (111)In-TNM(6.6)- and (111)In-HNB(2.0)-BSA, derivatives with a high degree of modification, showed a slightly faster disappearance from the systemic circulation and slightly higher accumulation in the liver than (111)In-unmodified BSA. Pharmacokinetic analyses also demonstrated that the modification of Tyr or Trp residues on BSA had only marginal effects on tissue distribution. These results indicate that the Tyr and Trp residues have little effect on the tissue distribution characteristics of serum albumins, and that the specific modification of these residues may be a promising approach to designing sustained drug delivery systems using serum albumins.  (+info)

The role of tryptophanyl residues in heavy meromyosin as studied by chemical modification with 2-hydroxy-5-nitrobenzyl bromide. (2/15)

1. Two moles of 2-hydroxy-5-nitrobenzyl group bound selectively to one mole of heavy meromyosin when it was treated with 2-hydroxy-5-nitrobenzyl bromide, a specific reagent for tryptophanyl residues. The binding with ADP, the size of the initial burst of Pi liberation and the difference absorption spectrum with and without ADP of the bound 2-hydroxy-5-nitrobenzyl groups were measured with heavy meromyosin modified with various amounts of reagent. The properties of the modified heavy meromyosin did not change until the molar binding ratio of the reagent, rH, was about 1, but the properties changed remarkably when rH increased from 1 to 2. 2. Subfragment-1 was prepared from the modified heavy meromyosin by trypsin [EC 3.4.21.4] digestion. The molar binding ratio of the reagent in subfragment-1, rS, was found to be less than 0.1 when rH of the starting heavy meromyosin was less than 0.8. However, rS was about 0.5 in subfragment-1 prepared from heavy meromyosin of rH about 2. The results indicate that only one mole of 2-hydroxy-5-nitrobenzyl group, which was bound with lower reactivity than the other, was bound to a head part of heavy meromyosin. 3. Subfragment-1 fraction prepared from the modified heavy meromyosin could be separated into two fractions by DE-32 cellulose column chromatography; the subfragment-1 portion which eluted later showed a higher rS than that eluted in front. The binding with ADP, the size of the initial burst of Pi liberation and the difference absorption spectrum induced by ATP were measured with the modified subfragment-1 separated by DE-32 cellulose column chromatography. The ADP-binding ability and the size of the initial burst were not dependent on rS, and coincided with those of subfragment-1 prepared from unmodified heavy meromyosin. 4. The results of ADP binding studies suggest that heavy meromyosin is constituted from nonidentical subunits, and that there is an interaction between them which controls the ADP binding. Two tryptophanyl residues having specific reactivity toward 2-hydroxy-5-nitrobenzyl bromide are assumed to be involved in the interaction.  (+info)

Chemical modification and 1H-NMR studies on the receptor-binding region of human interleukin 6. (3/15)

Oxidation of the Met residues of human interleukin 6 (IL-6) molecule has been performed. Reactivity of Met for the oxidation reaction was found to decrease in the order of Met50, Met118, Met185, Met162, and Met68. Chemical modifications involving oxidation and carboxypeptidase A digestion of IL-6 have led to the assignments of the methyl proton resonances of Met162 and Met185, respectively. The hydroxynitrobenzyl chromophore attached to Trp158 in the IL-6 molecule showed a different absorption spectrum when the labeled IL-6 was bound to the soluble IL-6 receptor. This result indicates that Trp158 is near the receptor-binding region in IL-6. On the basis of the 1H-NMR and chemical modification data, it has been concluded that Trp158 is in spatial proximity to Met162, His165 and Met185. The receptor-binding activity decreased with an increase in the number of oxidized Met residues. Of these five Met residues, Met162 was the residue in which the receptor-binding activity decreased in the most parallel degree with that of the oxidation reaction.  (+info)

The preparation and some properties of mammalian cytochrome c modified with 2-hydroxy-5-nitrobenzyl bromide. (4/15)

2-Hydroxy-5-nitrobenzyl bromide reacts with horse heart cytochrome c at acid pH to yield a chemically modified protein. Chromatography of the protein on CM-cellulose allows separation of a single chemically modified species. This species is shown by gel chromatography to be monomeric, and isoelectric focusing shows the pI to be lowered from 10.5 to 9.8 on introduction of the reagent molecule. The changes observed in the u.v. region of the spectrum are consistent with the introduction of a single residue of the reagent, and the normal fluorescence of tryptophan is lost. The chemically modified protein exhibits marked changes in its functional properties as compared with native cytochrome c. Unlike the native monomer, the modified cytochrome c has a pH-dependent spectrum which is typical of a high-spin species in the alpha/beta region at low pH, changing to a low-spin species with an apparent pK of 7.5. The modified protein is autoxidizable and the ferrous form binds CO at neutral pH with an affinity constant of 2.6 X 10(5)M-1. The ferrous form of the modified cytochrome c binds CN- at pH 10.0 with an affinity constant of 3.5 X 10(2)M-1. The modified cytochrome c was incapable of restoring the electron-transfer activity to mitochondria depleted of cytochrome c.  (+info)

Kinetic studies on mammalian cytochrome c modified with 2-hydroxy-5-hydroxy-5-nitrobenzyl bromide. (5/15)

The reduction of 2-hydroxy-5-nitrobenzyl tryptophyl cytochrome c by the chromous ion was studied by stopped-flow techniques. At pH6.5 the reduction of 2-hydroxy-5-nitrobenzyl tryptophyl cytochrome c is complex, showing the presence of three distinct phases. Two chromium concentration-dependent phases are observed (1.1 X 10(5) M-1-S-1, phase 1; 1.25 X 10(4)M-1-S-1, phase 2) and one slow first-order process (0.25S-1, phase 3). A comparison of the static and kinetic difference spectra, along with the data from the reduction of the reoxidized reduced protein, suggests that the slow chromium concentration-independent phase is due to a slow conformational event after fast reduction of the NO2 group. The rates of the chromium concentration-dependent phases show a marked variation with pH above 7.5. The activation energies for the three processes were also measured at 33.2, 38.6 and 69.7 kJ-mol-1 for phases 1, 2 and 3 respectively. The reaction of reduced 2-hydroxy-5-nitrobenzyl tryptophyl cytochrome c with CO was foollowed by means of both stopped-flow and flash photolysis. The combination with CO at pH 6.8 as measured in stopped-flow experiments showed two phases, one CO-dependent phase (phase 2, 2.4 X 10(2)M-1-S-1) and one CO-independent phase (phase 1, 0.015S-1). Investigation of the pH-dependence of the phases showed both the rates and amounts of each phase to be pH-invariant. CO recombination, after photolytic removal, was found to be biphasic; a CO-dependent phase (phase 2, 2.4 X 10(2)M-1-S-1) and a CO-independent phase (phase 1, 1.0s-1) were observed. A tentative model which can accommodate these observations is proposed.  (+info)

Identification of amino acid residues essential for the enzymatic activities of pertussis toxin. (6/15)

The enzymatic ADP-ribosyltransferase activity associated with the S1 subunit of pertussis toxin is considered to be responsible for its biological effects. Although pertussis toxin has no significant homology to other ADP-ribosylating toxins such as diphtheria toxin and Pseudomonas aeruginosa exotoxin A, the results presented in this paper show that, as for diphtheria toxin and exotoxin A, tryptophan and glutamic acid residues are essential for the enzymatic activities of pertussis toxin. Moreover, a structural motif can be identified around the critical glutamic acid residue. Chemical modification or site-directed deletion or replacement of Trp-26 abolishes ADP-ribosyltransferase and the associated NAD glycohydrolase activities. Both enzymatic activities are also abolished when Glu-129 is deleted or replaced by aspartic acid. Mutations at the Glu-106 position do not significantly reduce the enzymatic activities of the S1 subunit. The mutations do not affect the ability of the different S1 forms to be recognized by a variety of monoclonal antibodies, including neutralizing antibodies. Pertussis toxin containing a deletion or replacement of Trp-26, Glu-129, or both in the S1 subunit should thus be devoid of toxic activities without losing its reactivity with protective antibodies and, therefore, could be safely included in new generation vaccines against whooping cough.  (+info)

Chemical modification of a xylanase from a thermotolerant Streptomyces. Evidence for essential tryptophan and cysteine residues at the active site. (7/15)

Extracellular xylanase produced in submerged culture by a thermotolerant Streptomyces T7 growing at 37-50 degrees C was purified to homogeneity by chromatography on DEAE-cellulose and gel filtration on Sephadex G-50. The purified enzyme has an Mr of 20,463 and a pI of 7.8. The pH and temperature optima for the activity were 4.5-5.5 and 60 degrees C respectively. The enzyme retained 100% of its original activity on incubation at pH 5.0 for 6 days at 50 degrees C and for 11 days at 37 degrees C. The Km and Vmax. values, as determined with soluble larch-wood xylan, were 10 mg/ml and 7.6 x 10(3) mumol/min per mg of enzyme respectively. The xylanase was devoid of cellulase activity. It was completely inhibited by Hg2+ (2 x 10(-6) M). The enzyme degraded xylan, producing xylobiose, xylo-oligosaccharides and a small amount of xylose as end products, indicating that it is an endoxylanase. Chemical modification of xylanase with N-bromosuccinimide, 2-hydroxy-5-nitrobenzyl bromide and p-hydroxymercuribenzoate (PHMB) revealed that 1 mol each of tryptophan and cysteine per mol of enzyme were essential for the activity. Xylan completely protected the enzyme from inactivation by the above reagents, suggesting the presence of tryptophan and cysteine at the substrate-binding site. Inactivation of xylanase by PHMB could be restored by cysteine.  (+info)

Chemical modification of the bifunctional human serum pseudocholinesterase. Effect on the pseudocholinesterase and aryl acylamidase activities. (8/15)

The effect of chemical modification on the pseudocholinesterase and aryl acylamidase activities of purified human serum pseudocholinesterase was examined in the absence and presence of butyrylcholine iodide, the substrate of pseudocholinesterase. Modification by 2-hydroxy-5-nitrobenzyl bromide, N-bromosuccinimide, diethylpyrocarbonate and trinitrobenzenesulfonic acid caused a parallel inactivation of both pseudocholinesterase and aryl acylamidase activities that could be prevented by butyrylcholine iodide. With phenylglyoxal and 2,4-pentanedione as modifiers there was a selective activation of pseudocholinesterase alone with no effect on aryl acylamidase. This activation could be prevented by butyrylcholine iodide. N-Ethylmaleimide and p-hydroxy-mercuribenzoate when used for modification did not have any effect on the enzyme activities. The results suggested essential tryptophan, lysine and histidine residues at a common catalytic site for pseudocholinesterase and aryl acylamidase and an arginine residue (or residues) exclusively for pseudocholinesterase. The use of N-acetylimidazole, tetranitromethane and acetic anhydride as modifiers indicated a biphasic change in both pseudocholinesterase and aryl acylamidase activities. At low concentrations of the modifiers a stimulation in activities and at high concentrations an inactivation was observed. Butyrylcholine iodide or propionylcholine chloride selectively protected the inactivation phase without affecting the activation phase. Protection by the substrates at the inactivation phase resulted in not only a reversal of the enzyme inactivation but also an activation. Spectral studies and hydroxylamine treatment showed that tyrosine residues were modified during the activation phase. The results suggested that the modified tyrosine residues responsible for the activation were not involved in the active site of pseudocholinesterase or aryl acylamidase and that they were more amenable for modification in comparison to the residues responsible for inactivation. Two reversible inhibitors of pseudocholinesterase, namely ethopropazine and imipramine, were used as protectors during modification. Unlike the substrate butyrylcholine iodide, these inhibitors could not protect against the inactivation resulting from modification by 2-hydroxy-5-nitrobenzyl bromide, N-bromosuccinimide and trinitrobenzenesulfonic acid. But they could protect against the activation of pseudocholinesterase and aryl acylamidase by low concentrations of N-acetylimidazole and acetic anhydride thereby suggesting that the binding site of these inhibitors involves the non-active-site tyrosine residues.  (+info)

5-(4-Nitrobenzyl)-[1,3,4]thiadiazol-2-ylamine 247225-84-9 NMR spectrum, 5-(4-Nitrobenzyl)-[1,3,4]thiadiazol-2-ylamine H-NMR spectral analysis, 5-(4-Nitrobenzyl)-[1,3,4]thiadiazol-2-ylamine C-NMR spectral analysis ect.
4-Chloro-2-nitrobenzyl chloride, 98%, ACROS Organics™ 1g 4-Chloro-2-nitrobenzyl chloride, 98%, ACROS Organics™ Benzyl chlorides
2-Nitrobenzyl chloride | C7H6ClNO2 | CID 11921 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule n-(4-{hydroxy[(4-nitrobenzyl)oxy]phosphoryl}butanoyl)glycine (C13H17N2O8P) from the PQR.
Until recently, crystallographic studies of P450 2B enzymes were mainly focused on rabbit 2B4 because of its optimal solubility and stability during purification and crystallization. A series of crystal structures of 2B4 identified the active site residues that are involved in substrate recognition and ligand binding. In the closed structures of 2B4 in complex with 4-CPI and 1-CPI, residues contacting the ligand include Ile101, Val104, Ile114, Phe115, Phe206, Ile209, Phe297, Ala298, Glu301, Thr302, Ile362, Val367, and Val477, which are mainly hydrophobic except for Glu301 and Thr302 (Scott et al., 2004; Zhao et al., 2007). The corresponding residues in the active site of 2B6 deduced from the 4-CPI complex were essentially the same, with the only substitution occurring at residue 363, which is Ile in 2B4 and Leu in 2B6. In addition, the structure of 2B6 in complex with 4-CPI revealed similarities in the orientations of side chains involved in binding the inhibitor compared with the 2B4-4-CPI ...
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Guzei IA, Spencer LC, Lin Q, Blackwell HE. N-{(Aminocarbonyl) (S)-4-nitrobenzyl methyl}-N-{ (R)-cyclohexyl (cyclohe xylaminocarbonyl)methyl}propanamide methanol solvate. Acta Crystallographica Section E-Structure Reports Online. 2007 ;63:O1892-O1894. ...
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Synthesis, purification, and characterization of 3′‐O‐caged 2′‐deoxyribonucleoside triphosphates (dNTPs), namely 3′‐O‐(2‐nitrobenzyl)‐2′‐deoxy ribonucleoside triphosphates (NB‐dNTPs) and 3′‐O‐(4,5‐dimethoxy‐2‐nitrobenzyl)‐2′‐deoxy ribonucleoside triphosphates (DMNB‐dNTPs), are discussed in detail
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Find quality suppliers and manufacturers of 128-08-5(N-Bromosuccinimide) for price inquiry. where to buy 128-08-5(N-Bromosuccinimide).Also offer free database of 128-08-5(N-Bromosuccinimide) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Contents may develop pressure upon prolonged storage. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Handle under an inert atmosphere. Use only in a chemical fume hood. Prevent build up of vapors to explosive concentration. Keep from contact with moist air and steam. Do not breathe dust or fumes ...
Visit ChemicalBook To find more N-Bromosuccinimide(128-08-5) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of N-Bromosuccinimide(128-08-5). At last,N-Bromosuccinimide(128-08-5) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
The reactions of ( E)-cyclooctene with N-bromosuccinimide in the presence of water or methanol are described. Major products of the hydroxybromination are trans-4-bromocyclooctanol as a product of...
Pseudocholinesterase deficiency is an inherited blood plasma enzyme abnormality in which the bodys production of butyrylcholinesterase (BCHE; pseudocholinesterase) is impaired. People who have this abnormality may be sensitive to certain anesthetic drugs, including the muscle relaxants succinylcholine and mivacurium as well as other ester local anesthetics. Multiple studies done both in and outside India have shown an increased prevalence of pseudocholinesterase deficiency amongst the Arya Vysya community. A study performed in the Indian State of Tamil Nadu in Coimbatore, on 22 men and women from this community showed that 9 of them had pseudocholinesterase deficiency, which translates to a prevalence that is 4000-fold higher than that in European and American populations. Pseudocholinesterase deficiency (anesthesia sensitivity) is an autosomal recessive condition common within the Persian and Iraqi Jewish populations. Approximately one in 10 Persian Jews are known to have a mutation in the ...
Pseudocholinesterase deficiency is a rare genetic condition where the affected individual has increased sensitivity to several anesthetic agents. The use of these drugs may leave some of the muscles paralyzed
K.M. KUTTY, V. ANNAPURNA, V. PRABHAKARAN; Pseudocholinesterase: a protein with functions unrelated to its name. Biochem Soc Trans 1 June 1989; 17 (3): 555-556. doi: https://doi.org/10.1042/bst0170555. Download citation file:. ...
IV onset in 30s to 1 minute, lasting 2-3 minutes, with offset typically within 10 minutes. Offset occurs due to dissociation of drug out of NMJ into plasma, as a concentration gradient is established by drug breakdown in plasma. Prolonged duration in patients with pseudocholinesterase deficiency. IM onset in 2-3 minues ...
The catalytic asymmetric bromoamination of chalcones with N-bromosuccinimide as both bromine and amide source was realized by using a chiral N,N′-dioxide-Sc(NTf2)3 complex as an efficient catalyst. The corresponding chiral bromoamination products were obtained in high yields with high dr and good ee values (
Description: Alkenes treated with N-bromosuccinimde (NBS) and water will form bromohydrins. [private_ReactionGuide] Notes: The reaction is Markovnikoff selective and provides the trans-product. NBS stands for N-bromosuccinimide, it looks like this: Examples: Notes: Note how in examples 1
TY - JOUR. T1 - Weight. T2 - Succinylcholine requirement and pseudocholinesterase activity?. AU - Bentley, J. B.. AU - Borel, J. D.. AU - Vaughan, R. W.. AU - Gandolfi, A. J.. PY - 1981/1/1. Y1 - 1981/1/1. UR - http://www.scopus.com/inward/record.url?scp=0019790277&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0019790277&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0019790277. VL - 55. SP - A213. JO - Anesthesiology. JF - Anesthesiology. SN - 0003-3022. IS - 3 Suppl.. ER - ...
... is an oral anticoagulant of the coumarin series, synthesized and developed in the Geigy laboratoires in the late 1960s and sold in the United States under the brand name of Sintrom. It lowers the prothrombin level of the blood. It is a white crystalline powder without taste and odor and has a molecular weight of 353. It is soluble in alkaline solutions but only slightly soluble in water and organic solvents. Chemically, acenocoumarol is 3-(alpha-acetonyl-4-nitrobenzyl)-4-hydroxycoumarin. ...
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315.0 Kg o-Nitrotoluene was mixed with 1000 Lit Monochlorobenzene. To this mixture 275.0 Kg 3,5- Dibromo dimethylhydantoin & 26.0 Kg Azoisobutyronitrile (AIBN) was charged. The reaction mixture was digested for 10 hr at 60°C. After cooling, sodium carbonate solution (10%) charged to adjust pH 9.5. 175.0 Kg N-methylcyclohexylamine was added to the reaction mixture and the reaction mixture was digested for 8 hr at 85°C. Organic and aqueous layers were separated. Organic layer was charged with dilute hydrochloric acid solution. Monocholorobenzene layer was separated after complete formation of hydrochloride salt of the product. The aqueous acidic layer was then basified with caustic lye to yield 350.0 Kg of N-(2-nitrobenzyl)-N-methylcyclohexylamine of formula II. Organic layer was steam distilled to recover Monochlorobenzene, which is recycled in next batch ...
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Global N-Bromosuccinimide Market Research Report 2017 is a market research report available at US $2900 for a Single User PDF License from RnR Market Research Reports Library.
A simple, sensitive and rapid spectrophotometric method has been developed for the determination of aripiprazole in pharmaceutical formulations. The proposed method is based on the..
7-Benzyl-3- tert -butyl-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C22H25N3O, (I), and 3- tert -butyl-7-(4-methylbenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H27N3O, (II), are isomorphous in the space group P21, and molecules are linked into chains by C,H...O hydrogen bonds. In each of 3- tert -butyl-7-(4-methoxybenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H27N3O2, (III), which has cell dimensions rather similar to those of (I) and (II), also in P21, and 3- tert -butyl-1-phenyl-7-[4-(trifluoromethyl)benzyl]-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C23H24F3N3O, (IV), there are no direction-specific interactions between the molecules. In 3- tert -butyl-7-(4-nitrobenzyl)-1-phenyl-6,7-dihydro-1H,4H -pyrazolo[3,4- d][1,3]oxazine, C22H24N4O3, (V), a combination of C,H...O and C,H...N hydrogen bonds links the molecules into complex sheets. There are no direction-specific interactions between the molecules of 3- tert ...
There are no differences, between human normal and allergic sera, in the total activity of naphthylacetate-hydrolysing enzymes. No abnormal dibucaine-inhibited isoenzymes were detected. The Michaelis constants and the activation energies of serum pseudocholinesterases in the sera of patients with atopic disease, urticaria, or extrinsic allergic alveolitis were within the normal ... read more range. show less ...
see article for more examples. Abstract. Unsaturated compounds such as alkenes, alkynes, allenes, and methylenecyclopropanes (MCPs) can be dibrominated within minutes by NBS and lithium bromide in THF at room temperature in good to excellent yields under mild conditions.. ...
... vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455.849.291.850 --- taxoids MeSH D02.455.849.291.850.777 ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH ... 5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH D02.092. ... 2,3-diketogulonic acid MeSH D02.241.081.844.300 --- glucaric acid MeSH D02.241.081.844.322 --- gluconates MeSH D02.241.081.844. ...
... triphenylphosphonium bromide] in a mouse model of visceral leishmaniasis were established. Compound 1 reduced the parasite load ... 2-hydroxy-5-nitrobenzyl Bromide. A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein ... A readily available quaternary phosphonium salt containing a trifluoroacetonyl group and a tetrakis[3,5-bis(trifluoromethyl) ... The pharmacokinetics and in vivo oral efficacy of compound 1 [(16-(2,4-dihydroxyphenyl)-16-oxohexadecyl) ...
5-(3,4-DIHYDRO-5,6,7-TRIMETHOXY-1-NAPHTHALENYL)-2-METHOXY-,PHENOL, 5-(3,4-DIHYDRO-6,7,8-TRIMETHOXY-1-NAPHTHALENYL)-2-METHOXY- ... 3-HYDROXY-4-NITROBENZYL BROMIDE Molecular Formula: C7H6BrNO3. Molecular Weight: 232.031440 [g/mol]. ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 1 2 3 4 5 * ... C20H22O5. Molecular Weight: 342.385680 [g/mol]. H-Bond Donor: 1 ... 111394-51-5. Phenol, 5-(bromomethyl)-2-nitro- (2 suppliers). IUPAC Name: 5-(bromomethyl)-2-nitrophenol , CAS Registry Number: ...
Kinetic studies on mammalian cytochrome c modified with 2-hydroxy-5-hydroxy-5-nitrobenzyl bromide Biochem J (July,1975) ... Potentiation of phase 1 and inhibition of phase 2 of glucose-induced insulin secretion Biochem J (February,1990) ...
2.Istituto di Tecniche Spettroscopiche CNR MessinaMessinaItaly. *3.Istituto di Chimica Farmaceutica e TossicologicaUniversità ... 2-hydroxy-5-nitrobenzyl bromide, J. Am. Chem. Soc. 87: 1126CrossRefGoogle Scholar ...
... vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455.849.291.850 --- taxoids MeSH D02.455.849.291.850.777 ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH ... 5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH D02.092. ... 2,3-diketogulonic acid MeSH D02.241.081.844.300 --- glucaric acid MeSH D02.241.081.844.322 --- gluconates MeSH D02.241.081.844. ...
Modification with 2-hydroxy-5-nitrobenzyl bromide also indicated the participation of tryptophan in the activity of the enzyme ... preliminary kinetic studies indicated that the activation of citrate synthase by KCl is the result of an approximately 5-fold ...
Bromotrimethylammoniumbimane Bromide Bromotrimethylammoniumbimane Bromide is a fluorescent sulfhydryl active reagent derived of ... CruzQuench 2 maleimide CruzQuench™ 2 maleimide is a thiol-reactive peptide and oligonucleotide label sc-362636 5 mg. $234.00 0 ... N-[4-(5,6-Dimethoxy-N-phthalimidinyl)phenyl]maleimide is a thiol-reactive compound 143503-03-1 sc-212049 10 mg. $153.00 0 ... 5-(4,6-Dichloro-s-triazin-2-ylamino)fluorescein hydrochloride is a protein label 51306-35-5 sc-290672 100 mg. $119.00 0 ...
What is 2-hydroxy-dATP diphosphatase? Meaning of 2-hydroxy-dATP diphosphatase medical term. What does 2-hydroxy-dATP ... Looking for online definition of 2-hydroxy-dATP diphosphatase in the Medical Dictionary? 2-hydroxy-dATP diphosphatase ... redirected from 2-hydroxy-dATP diphosphatase) NUDT1. A gene on chromosome 7p22 that encodes an antimutagenic enzyme which ... medical-dictionary.thefreedictionary.com/2-hydroxy-dATP+diphosphatase,NUDT1,/a,. *Facebook ...
... hydroxy-5-nitrobenzyl bromide did not affect the ratio. Modification with N-acetylimidazole resulted in a marginal increase in ... The molar absorptivity and Sandells sensitivity of monocrotophos and dichlrovos were found to be 7.1 x 10(5) (+100) 1 mole(-1 ... Protection using pepstatin A during modification with phenylglyoxal, N-acetylimidazole and 2-hydroxy-5-nitrobenzyl bromide, ... Prognostic utility of luminol (5-amino, 2-3 dihydro 1-4 phthalazinedione)-enhanced neutrophil chemiluminescence in fulminant ...
Cited By (2). * Cited by examiner, † Cited by third party. Publication number. Priority date. Publication date. Assignee. Title ... 5 ml of the colored eluate was recovered in 4 tubes.. 5 mg of Congo Red in one ml of distilled water and 4 mg of carbodiimide ... Citations (5). * Cited by examiner, † Cited by third party. Publication number. Priority date. Publication date. Assignee. ... Family Cites Families (5). * Cited by examiner, † Cited by third party. Publication number. Priority date. Publication date. ...
34 +/- 2 residues of tryptophan are found to be easily oxidized at a lower concentration of H2O2 during the first phase of the ... Results: Persistence of effectiveness of ICON 10 CS was observed up to 2-3 months in all the three study areas. ICON 10 CS was ... Withdrawal of ethanol for 2 months showed continued reduction of counts of neuronal density in layers II+III and V only whereas ... It is associated with pleural effusion and ascites (Pseudo-Meigs syndrome) in 5% of cases. The combination of struma ovarii ...
... this detection procedure is not only sensitive and rapid but also free of hazardous chemicals such as ethidium bromide. ... trihexyphenidyl 2 mg indikasi omeprazole 2016-04-27 The bioavailability of syntesen af citalopram reviews the coated and ... We report here that CDC14 is a low-copy suppressor of the dbf2-2 mutation at 37 degrees C. Some factors affecting prognosis in ... Group 1 was given uninephrectomy (UNX) and MAN treatment, group 2 was given UNX and was not treated with MAN and group 3 was ...
hydroxy-5-phenylpentanoic acid, 6-aminohexanoic acid, t-butylglycine. nonailine,. phenylglycine, ornithine, sarcosine, 4-amino ... chemical cleavage (e.g. cyanogen bromide). The peptides can also be synthesized by. expression of overlapping nucleic acid ... 5. The isolated peptide of Claim 1 or .2 or 3 wherein the T-cell epitqpe is on the Achain. of the proinsulin or insulin.. 6. ... T-cell clones (5 x. lO4 cells/well) were cultured in the presence of irradiated autologous PBMC (5 x 104/weH). and each peptide ...
... bromides and sulfates, organic acids such as acetates, propionates and malonates and pyrogen-free water. [0231] A useful ... 4-amino-3-hydroxy-5-phenylpentanoic acid, 4-amino-3-hydroxy-6-methylheptanoic acid, t-butylglycine, norleucine, norvaline, ... 0336] HOMP5: 5-CAA TTA ACG GCC GAA TAA AAG GAA GCC GAT ATG AAC AAA ATA TAC CGC ATC-3 (SEQ ID NO:40); [0337] SO-G: 5-CAG CGA ... 2 (SEQ ID NOS: 12-22). EXAMPLE 2 [0274] PMC 21 NhhA Polypeptide Over-Expression [0275] The NhhA protein encoded by the nhhA ...
D2.705.400.140.175 2,4,5-Trichlorophenoxyacetic Acid D2.241.511.316.881 D2.241.81.18.386.682.800 D2.241.511.316.682.800 2,4- ... 2-Ethyl 2-(4-Nitrophenyl) Ester D2.705.539.750 D2.705.429.812.750 D2.886.309.750 D2.705.539.692.750 D2.886.300.846.750 ... E4.680.275.700 RNA 5 Terminal Oligopyrimidine Sequence G2.111.570.80.689.687.500 G2.111.570.80.689.687.275 G5.360.80.689. ... D2.241.81.18.110.80 2-Hydroxy-5-nitrobenzyl Bromide D2.755.566.400 D2.455.426.559.389.657.566.400 2-Methyl-4- ...
... sulfonium bromide (DHNBS), which selectively labels solvent accessible tryptophan residues. Analysis of tryptophans labeled ... sulfonium bromide (DHNBS), which selectively labels solvent accessible tryptophan residues. Analysis of tryptophans labeled ... NH2-, and COOH-terminated alkanethiol self-assembled monolayer (SAM) surfaces. The bioactivities of the small proteins, TRP, ...
6-substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids and cogeners having useful antibacterial activity are ... The compounds are prepared in a reaction sequence starting with a 4-acyloxy-2-azetidinone. ... The chloride or bromide of formula XII is then reacted with a suitable phosphine, e.g., tri-p-methoxyphenyl phosphine, ... Suitable hydroxy protecting groups are those such as 2,2,2-trichloroethoxycarbonyl, 1,1,1-trichloro-2-methyl-2-propoxycarbonyl ...
3-(4-hydroxy benzoyl) 2-ethyl 1-methyl 4-nitro indole M.p.: 191° C. (water/acetic acid 7/3) d) 3-[4-(3-di-n-butylamino-propoxy) ... bromide and 120.2 g (1.52 mole) of pyridine in 700 ml of chloroform. The mixture is heated at reflux for 2 hours. 2800 ml of ... NH2 n-C4 H9. n-C4 H9. n-C4 H9. 10 53. CH3 SO2 -- n-C4 H9. n-C4 H9. n-C4 H9. 10 66. ##STR114## n-C4 H9. n-C4 H9. n-C4 H9. 10 23 ... In this manner, 9.3 g of 3-(4-hydroxy benzoyl) 2-n-butyl 1-methyl 5-nitro indole are obtained. ...
trans-4-Hydroxy-3-methoxy-beta-nitrostyrene *Molecular Formula: C9H9NO4 ... 4-(1-hydroxy-2-methylaminoethyl)phenol *Molecular Formula: C9H13NO2 ... octyl 4-hydroxy-3-methoxybenzenecarboximidoate *Molecular Formula: C16H25NO3 ... butyl 4-hydroxy-3-methoxybenzenecarboximidoate *Molecular Formula: C12H17NO3 ...
Hydroxy Butane Sulphonic Acid Potassium Salt 4-Chloro Butyraldehyde Diethyl Acetal Para Nitro Benzyl Bromide Para Nitro Benzyl ... Chemical Companies - O Hydroxy Benzyl Alcohol, Service .. List of chemical companies, o hydroxy benzyl alcohol Companies ... S.NO INTERMEDIATES CAS NO API; 1 (1S,4R)-(4-Aminocyclopent-2-enyl) Methanol Hydrochloride: 168960-19-8: Abacavir: 2 (1S,4R)-4-( ... Products supplying, 1, 4-dioxane n, n..bis ( 2-chloro ethyl ) amine hcl acetyl chloride, ammonium sulphate, bromine liquid, ...
Looking for online definition of 2-hr PC in the Medical Dictionary? 2-hr PC explanation free. What is 2-hr PC? Meaning of 2-hr ... 25-hydroxy-vitamin D. *2-acetylaminofluorine. *2-aminoethanesulfonic acid. *2-azetidinecarboxylic acid ... redirected from 2-hr PC). Also found in: Dictionary, Thesaurus, Encyclopedia. glucose. /glu·cose/ (gloo´kōs) 1. a six-carbon ... Q. What difference does fructose makes to a diabetic with respect to glucose? I am diabetic with type 2 NIDDM. My colleague ...
3-Hydroxy Phenyl Acetic Acid. Get Quotation 3- Hydroxy Phenyl Acetic Acid. ... 4- Nitrobenzyl Bromide 99%. Special Chemicals. Get Quotation 4- Acetylbenzonitrile. Get Quotation ...
Looking for 2-hr PC? Find out information about 2-hr PC. or monosaccharide sugar with the empirical formula C6H12O6 . This ... carbohydrate carbohydrate, any member of a large class of chemical compounds that includes... Explanation of 2-hr PC ... redirected from 2-hr PC). Also found in: Dictionary, Thesaurus, Medical. glucose,. dextrose,. or grape sugar,. monosaccharide ... The complete enzymatic oxidation of glucose to CO2 and H2O is accompanied by the release of energy: C6H12O6 + 602-6CO2 + 6H2O ...
  • A readily available quaternary phosphonium salt containing a trifluoroacetonyl group and a tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (BAr) counterion was demonstrated to be a highly active Brøns. (bioportfolio.com)
  • 2-(4-Fluorophenyl)-1-phenyl-1Himidazo[4,5-f][1,henanthroline monohydrate. (howard.edu)
  • A seven membered chelate ring complex of Mn(II) derived from bis(5-phenyl-2H-1,2,4-triazole)-3-yl-disulfane and cleavage of the S-S bond in a Co(II) complex: Synthesis, spectral and structural characterization. (howard.edu)
  • 3-[2-(6-Bromo-2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)ethyl]-1, 3-oxazolidin-2-one. (howard.edu)
  • Bis{2-[(Tri-phenyl-meth-yl)amino]-phen-yl} diselenide aceto-nitrile monosolvate. (nih.gov)
  • 6. A compound according to claim 5, wherein R 1 is phenyl substituted with two to three of halogen, mono(lower alkyl)amino, di(lower alkyl)amino, lower alkyl, lower alkoxyl, benzyloxyl or/and hydroxyl, and X 1 , X 2 and X 3 are each hydrogen. (google.com.au)
  • 11. A compound according to claim 10, wherein R 1 is unsubstituted phenyl, and X 1 is C 1-4 alkyl, X 2 is C 1-4 alkoxyl and X 3 is hydrogen. (google.com.au)
  • methylene- Imidazo[1 , 5-a]pyridine-1-carboxaldehyde 2-chloro-3-isopropyl-6-methylphenol 2-Bromo-5-Methoxybenzoyl Chloride D-Tryptophan , 6-chloro- 5-Amino-2-chloropyrimidine N-(4-Hydroxyphenyl)piperazine Benzeneethanol , .beta. (twfta.com)
  • The full-length cDNAs of CsGSTo1 and 2 constituted 965 bp and 1,061 bp with open reading frames of 737 bp (246 amino acids) and 669 bp (223 amino acids). (biomedcentral.com)
  • In order to gain further insights into adsorbed orientation and conformation, adsorbed HEWL and GOx layers on the various SAMs were chemically modified with dimethyl(2-hydroxy-5-nitrobenzyl)sulfonium bromide (DHNBS), which selectively labels solvent accessible tryptophan residues. (clemson.edu)
  • 1-(3,5-Dimethylphenyl)-2-(4-fluorophenyl)-4,5-dimethyl-1H-imidazole. (howard.edu)
  • 6-dimethyl- 2-Pyridinemethanamine , .alpha. (twfta.com)
  • 4 Hydroxyindole CAS number is 2380 94 1 It is an important intermediate for the synthesis of angina pectoris drug indorolol and the psychotropic drug dimethyl 4 hydroxytryptamine His synthesis methods are roughly as follows 1 Using 2 6 dinitrotoluene and paraformaldehyde as starting materials 2 6 dinitrophenylethanol. (volsenchem.com)
  • The invention relates to a new process for the preparation of (l'-tert-buto^carbonyl-2-oxo-[l,3l]-bipyrrolidinyl-3-(R)S)»yl)-triphenyl-phosphonium halogenide compounds of formula I wherein * signifies an asymmetric center with an (R) or (S) configuration and X represents chlorine, bromine or iodine. (allindianpatents.com)
  • High quality meropenem trihydrate non sterile can be offered Attach the COA of this product pls check the items API Meropenem with Sodium Carbonate CAS 119478 56 7 with best price Product Name Meropenem Trihydrate Synonyms Meropenem MEROPENEMTRIHYDRATE 3 5 DIMETHYLAMINO CARBONYL 3 PYRROLIDINYL THIO 6 1 HYDROXYETHYL 4. (carbapenemspharmacy.com)
  • The heteroaryl group may optionally contain 1 to 3 lower alkyl substituents, e.g.,2-methylpyridyl, 3-methylthienyl, etc. (patentgenius.com)
  • 2-Alkyl-3-benzoylbenzofurans and pharmaceutical compositions containing them. (freepatentsonline.com)
  • 11. The functionalized support material of claim 1 wherein R 3 is selected from the group consisting of --C(O)OZ, --C(O)SZ, --C(S)OZ, --C(OZ) 2 H and --C(OZ) 2 R 4 , wherein R 4 is an alkyl group. (google.ca)
  • Y is halogen and R 2 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof. (google.com.au)
  • dinitrobenzene - /daɪˌnaɪtroʊˈbɛnzin/ (say duy.nuytroh benzeen), / bɛnˈzin/ (say ben zeen) noun one of three isomeric compounds, C6H4(NO2)2, the most important of which is made by nitration of benzene or nitrobenzene and used in the manufacture of azo dyes. (avant-club.ru)
  • Dinitrobenzenes are chemical compounds composed of a benzene ring and two nitro group (-NO 2 ) substituents. (avant-club.ru)
  • Velpatasvir intermediate 9 Bromo 3 2 Bromo Acetyl 10 11 Dihydro 5H dibenzo c g Chromen 8 9H one CAS number is 1438383 89 1 his synthesis process is as following 1 Dissolve 5 0 g of 2 bromo 5 iodobenzyl alcohol in dry 40 mL of tetrahydrofuran cool the system to below 10 C and slowly add 17 6 mL of isopropylmagnesium. (volsenchem.com)
  • From the monomers in the synthetic scheme below, polymers were made that were endcapped with either a UV degradable o-nitrobenzyl alcohol group or a NIR degradable bromo-coumarin group. (blogspot.com)
  • 16. A pharmaceutical composition which contains an amount effective for producing hypotensive activity in a mammal of a compound of claim 2, 6, 11, 1-15 or 3, and a pharmaceutically acceptable carrier, vehicle or diluent therefor. (google.com.au)
  • Monocalcium Phosphate Monocalcium phosphate is a chemical compound with the formula Ca(H2PO4)2. (tradeindia.com)
  • The full chemical name of Velpatasvir intermediate GS 5818 interMediate is 3 Chloro 10 11 dihydro 5H 9H 6 oxa benzo a anthracen 8 one cas number 1378388 20 5 It Uses 2 bromo 5 chlorobenzyl bromide as raw material alkylation reaction with 7 hydroxytetralinone under the action of potassium carbonate to obtain an. (volsenchem.com)
  • 2、You can input the English name, Chinese name,alias, or CAS number (American chemical abstract registration number) of the chemical to search. (guidechem.com)
  • Journal of Chemical and Pharmaceutical Research, 5 (7). (uni-mysore.ac.in)
  • 6. The method of claim 5 wherein the substrate is a carbon-layer/hardmask. (google.com)
  • 5. The pattern forming process of claim 4 wherein the substrate bears thereon an underlay on which the coating of the resist composition is formed, said process further comprising the step of treating the underlay by oxygen plasma etching, after the resist pattern formation. (google.com.au)
  • The pharmacokinetics and in vivo oral efficacy of compound 1 [(16-(2,4-dihydroxyphenyl)-16-oxohexadecyl)triphenylphosphonium bromide] in a mouse model of visceral leishmaniasis were established. (bioportfolio.com)
  • 5. A method of treating bacterial infection in a mammal comprising administering a compound of claim 1 to said mammal in an amount effective to treat bacterial infection. (patentgenius.com)
  • 2. A compound according to claim 1, in which Q.sub.1 stands for the grouping ##STR36## Z having the meaning defined in claim 1. (patents.com)
  • 5. A compound according to claim 1, in which Q.sub.2 stands for oxygen. (patents.com)
  • 2. The functionalized support material of claim 1 wherein L is chosen such that the N--L bond is cleavable under conditions that do not adversely affect the organic compound being synthesized. (google.ca)
  • 2. A compound according to claim 1, wherein Y is chlorine. (google.com.au)
  • 17. A method for producing hypotensive activity in a mammal, which comprises administering to said mammal a hypotensively effective amount of a compound of claim 2, 6, 11, 1-15 or 3. (google.com.au)
  • 2. A benzolactam compound as claimed in claim 1, wherein said compounds are trans-3(S)-[.gamma. (patents.com)
  • 3. The compound according to claim 2, wherein said L is independently a single covalent bond or a covalent linkage having 1-20 nonhydrogen atoms selected from the group consisting of C, N, O, P, and S. (patentsencyclopedia.com)
  • 6. The compound according to claim 2, wherein one of R 30 , R 31 , R 32 , R 33 , and R 34 is -L-R x , or -L-S c . (patentsencyclopedia.com)
  • 2. A compound of claim 1, wherein said compound contains at least one paramagnetic ion of an element of atomic numbers 21-29, 42, 44 or 57-70. (segmented.us)
  • 5. A compound of claim 1, wherein the porphyrin skeleton chelates manganese. (segmented.us)
  • 6. A compound according to claim 5, wherein at least one of R 1 and R 2 is (NH) x --[Q--(NH) y ] w --V--K and K is a complexing agent of formula IA, IB, IC or ID and said complexing agent contains at least one paramagnetic metal ion of an element of atomic numbers 21-29, 42, 44 or 57-70. (segmented.us)
  • A fluorogenic substrate for detecting caspase-1, caspase-4, and caspase-5 activity. (sri.com)
  • 6-substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids and cogeners having useful antibacterial activity are disclosed. (patentgenius.com)
  • The present invention relates to 6-substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids and congeners. (patentgenius.com)
  • Bacterially expressed recombinant proteins (rCsGSTo1 and 2) exhibited dehydroascorbate reductase (DHAR) and thioltransferase activities. (biomedcentral.com)
  • Expression of CsGSTo transcripts and proteins increased beginning in 2-week-old juveniles and reached their highest levels in 4-week-old adults. (biomedcentral.com)