2-Chloroadenosine
Adenosine
Receptors, Purinergic
Adenosine-5'-(N-ethylcarboxamide)
Receptors, Purinergic P1
Purinergic P1 Receptor Antagonists
Theophylline
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
8-Bromo Cyclic Adenosine Monophosphate
Phenethylamines
Receptor, Adenosine A2B
Adenosine Deaminase
Pyran Copolymer
Dipyridamole
Tubercidin
Adenosine Kinase
Cyclic AMP
Receptor, Adenosine A2A
Muscarine
Interruption of transmembrane signaling as a novel antisecretory strategy to treat enterotoxigenic diarrhea. (1/208)
Bacteria that produce heat-stable enterotoxins (STs), a leading cause of secretory diarrhea, are a major cause of morbidity and mortality worldwide. ST stimulates guanylyl cyclase C (GCC) and accumulation of intracellular cyclic GMP ([cGMP]i), which opens the cystic fibrosis transmembrane conductance regulator (CFTR)-related chloride channel, triggering intestinal secretion. Although the signaling cascade mediating ST-induced diarrhea is well characterized, antisecretory therapy targeting this pathway has not been developed. 2-ChloroATP (2ClATP) and its cell-permeant precursor, 2-chloroadenosine (2ClAdo), disrupt ST-dependent signaling in intestinal cells. However, whether the ability to disrupt guanylyl cyclase signaling translates into effective antisecretory therapy remains untested. In this study, the efficacy of 2ClAdo to prevent ST-induced water secretion by human intestinal cells was examined. In Caco-2 human intestinal cells, ST increased [cGMP]i, induced a chloride current, and stimulated net basolateral-to-apical water secretion. This effect on chloride current and water secretion was mimicked by the cell-permeant analog of cGMP, 8-bromo-cGMP. Treatment of Caco-2 cells with 2ClAdo prevented ST-induced increases in [cGMP]i, chloride current and water secretion. Inhibition of the downstream consequences of ST-GCC interaction reflects proximal disruption of cGMP production because 8-bromo-cGMP stimulated chloride current and water secretion in 2ClAdo-treated cells. Thus, this study demonstrates that disruption of guanylyl cyclase signaling is an effective strategy for antisecretory therapy and provides the basis for developing mechanism-based treatments for enterotoxigenic diarrhea. (+info)Depletion of alveolar macrophages by treatment with 2-chloroadenosine aerosol. (2/208)
Alveolar macrophages (AMs) are localized in the alveoli and alveolar ducts of the lung and are the only macrophages living in an aerobic environment. Recent studies have demonstrated that AMs play a central role in lung diseases, such as pneumonia and acute respiratory distress syndrome. It has become important to find a simple, effective way to eliminate AMs in order to investigate the function of AMs in vivo. 2-Chloroadenosine (2-CA), a purine analog, is reported to be selectively cytotoxic to cultured macrophages, and we hypothesized that it would deplete the number of AMs in the bronchoalveolar lavage fluid (BALF) of mice without any effect on neutrophil or lymphocyte counts. After mice had inhaled 1 mM aerosolized 2-CA for 2 h, AMs were found to be significantly depleted at 0 h [(4.42 +/- 0.16) x 10(4)/ml], 24 h [(4.17 +/- 0.89) x 10(4)/ml], 48 h [(3.17 +/- 0.21) x 10(4)/ml], and 72 h [(5.00 +/- 0.64) x 10(4)/ml] compared with concentrations in untreated controls [(12.1 +/- 0.21) x 10(4)/ml]. Neutrophil and lymphocyte counts in BALF did not change and histological changes in the lung were not observed after 2-CA treatment. The lung wet-to-dry weight ratio did not change at 0, 24, and 48 h after 2-CA aerosol application. The 2-CA aerosol had no effect on lung vascular permeability, as assessed by the intravenous administration of Evans blue, or on other phagocytes, as assessed by Kupffer cell counts. Our study demonstrates the efficacy of 2-CA in reducing AM numbers in vivo. (+info)A(2B) receptors mediate antimitogenesis in vascular smooth muscle cells. (3/208)
Adenosine inhibits growth of vascular smooth muscle cells. The goals of this study were to determine which adenosine receptor subtype mediates the antimitogenic effects of adenosine and to investigate the signal transduction mechanisms involved. In rat aortic vascular smooth muscle cells, platelet-derived growth factor-BB (PDGF-BB) (25 ng/mL) stimulated DNA synthesis ([(3)H]thymidine incorporation), cellular proliferation (cell number), collagen synthesis ([(3)H]proline incorporation), total protein synthesis ([(3)H]leucine incorporation), and mitogen-activated protein (MAP) kinase activity. The adenosine receptor agonists 2-chloroadenosine and 5'-N-methylcarboxamidoadenosine, but not N(6)-cyclopentyladenosine or CGS21680, inhibited the growth effects of PDGF-BB, an agonist profile consistent with an A(2B) receptor-mediated effect. The adenosine receptor antagonists KF17837 and 1,3-dipropyl-8-p-sulfophenylxanthine, but not 8-cyclopentyl-1, 3-dipropylxanthine, blocked the growth-inhibitory effects of 2-chloroadenosine and 5'-N-methylcarboxamidoadenosine, an antagonist profile consistent with an A(2) receptor-mediated effect. Antisense, but not sense or scrambled, oligonucleotides to the A(2B) receptor stimulated basal and PDGF-induced DNA synthesis, cell proliferation, and MAP kinase activity. Moreover, the growth-inhibitory effects of 2-chloroadenosine, 5'-N-methylcarboxamidoadenosine, and erythro-9-(2-hydroxy-3-nonyl) adenine plus iodotubericidin (inhibitors of adenosine deaminase and adenosine kinase, respectively) were abolished by antisense, but not scrambled or sense, oligonucleotides to the A(2B) receptor. Our findings strongly support the hypothesis that adenosine causes inhibition of vascular smooth muscle cell growth by activating A(2B) receptors coupled to inhibition of MAP kinase activity. Pharmacological or molecular biological activation of A(2B) receptors may prevent vascular remodeling associated with hypertension, atherosclerosis, and restenosis following balloon angioplasty. (+info)Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o). (4/208)
To examine the role of G(o) in modulation of ion channels by neurotransmitter receptors, we characterized modulation of ionic currents in hippocampal CA3 neurons from mice lacking both isoforms of Galpha(o). In CA3 neurons from Galpha(o)(-/-) mice, 2-chloro-adenosine and the GABA(B)-receptor agonist baclofen activated inwardly rectifying K(+) currents and inhibited voltage-dependent Ca(2+) currents just as effectively as in Galpha(o)(+/+) littermates. However, the kinetics of transmitter action were dramatically altered in Galpha(o)(-/-) mice in that recovery on washout of agonist was much slower. For example, recovery from 2-chloro-adenosine inhibition of calcium current was more than fourfold slower in neurons from Galpha(o)(-/-) mice [time constant of 12.0 +/- 0.8 (SE) s] than in neurons from Galpha(o)(+/+) mice (time constant of 2.6 +/- 0.2 s). Recovery from baclofen effects was affected similarly. In neurons from control mice, effects of both baclofen and 2-chloro-adenosine on Ca(2+) currents and K(+) currents were abolished by brief exposure to external N-ethyl-maleimide (NEM). In neurons lacking Galpha(o), some inhibition of Ca(2+) currents by baclofen remained after NEM treatment, whereas baclofen activation of K(+) currents and both effects of 2-chloro-adenosine were abolished. These results show that modulation of Ca(2+) and K(+) currents by G protein-coupled receptors in hippocampal neurons does not have an absolute requirement for Galpha(o). However, modulation is changed in the absence of Galpha(o) in having much slower recovery kinetics. A likely possibility is that the very abundant Galpha(o) is normally used but, when absent, can readily be replaced by G proteins with different properties. (+info)Possible role of immune surveillance at the initial phase of metastasis produced by B16BL6 melanoma cells. (5/208)
The relationship among the real-time trafficking of lung metastatic B16BL6 cells, metastatic potential, and the injected number of the cells was examined, since the smaller the number of tumor cells injected, the more clearly the immune defense may be observed. When 1x10(6) or 1x10(5) B16BL6 cells were injected into mice via the tail vein, both numbers of cells accumulated in the lung at a similar rate: there was an approximately 10-fold difference in the number of accumulated cells between the two doses. Elimination from the lung was not dependent on the cell number but on the proportion of accumulated cells. However, the injection of 1x10(4) cells resulted in lung accumulation less than one-tenth of that obtained with 1x10(5) cell injection. Metastasis was observed when 1x10(5) or 1x10(6) B16BL6 cells were injected, but not after injection of 1x10(4) cells. To clarify the roles of the immune defense system at the initial phase of metastasis, we challenged macrophage-depleted mice with 1x10(4) tumor cells. Treatment of mice with 2-chloroadenosine prior to the tumor cell challenge cancelled the suppression of not only metastasis but also the lung accumulation. Furthermore, the administration of 2-chloroadenosine following the tumor cell challenge had little effect on the metastatic potential. These results suggest that the immune surveillance whose action was obvious at the low dose of challenged tumor cells functions strongly at the initial phase but not at the advanced stages of the metastatic process, and that macrophages play an important role in the suppression of metastasis. (+info)Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells. (6/208)
We investigated the role of the cAMP link to the signal transduction mechanism coupled with adenosine A(2A) and A(2B) receptors in cultured human coronary artery endothelial cells (HCAEC) and porcine coronary artery endothelial cells (PCAEC). 2-[4-[2- inverted question mark2-[(4-aminophenyl)methylcarbonylamino]ethylaminocarbon yl inverted question marketh yl]phenyl]ethylamino-5'- ethylcarboxamidoadenosine ((125)I-PAPA-APEC) (PAPA-APEC) was used to demonstrate the specific binding in PCAEC membranes. The specific binding was saturable and reversible with a maximal number of binding sites (B(max)) of 240 fmol/mg protein, and scatchard analysis revealed a single class of binding site with an equilibrium dissociation constant (K(d)) of 1. 17 +/- 0.035 nM. In competition experiments, adenosine receptor agonists showed the following order of potency (based on IC(50)): 5'-(N-ethylcarboxamido)adenosine (NECA) >/= CGS-21680 > 2-chloroadenosine. This order appears to be consistent with the A(2) adenosine receptor classification. We also studied the effects of adenosine agonists on the accumulation of cAMP as an indirect approach to show the presence of functional A(2) receptors. Similarly, the same adenosine agonists (10(-7)-10(-4) M) elicited the production of cAMP in intact endothelial cells in a dose-dependent manner, exhibiting consistently with the A(2) adenosine receptor classification. A selective A(2A) adenosine receptor antagonist (ZM-241385, 10(-8) M) significantly inhibited the effect of CGS-21680 on cAMP but only partly inhibited the effect of NECA, suggesting the presence of both A(2A) and A(2B) receptors. Western blot analysis further showed the immunoreactivity of A(2A) and A(2B) receptor at 45 and 36 kDa, respectively, in both HCAEC and PCAEC. Direct evidence for the presence of A(2A) and A(2B) receptors in cultured HCAEC and PCAEC by reverse transcription-polymerase chain reaction (RT-PCR), revealed expected PCR product sizes (205 and 173 bp) for A(2A) and A(2B) receptors in HCAEC and PCAEC, respectively. The data show that adenylate cyclase-coupled adenosine A(2A) and A(2B) receptors are present in coronary endothelial cells. (+info)Selective transport of adenosine into porcine coronary smooth muscle. (7/208)
Adenosine (ADO), an endogenous regulator of coronary vascular tone, enhances vasorelaxation in the presence of nucleoside transport inhibitors such as dipyridamole. We tested the hypothesis that coronary smooth muscle (CSM) contains a high-affinity transporter for ADO. ADO-mediated relaxation of isolated large and small porcine coronary artery rings was enhanced 12-fold and 3.4-fold, respectively, by the transport inhibitor, S-(4-nitrobenzyl)-6-thioinosine (NBTI). Enhanced relaxation was independent of endothelium and was selective for ADO over synthetic analogs. Uptake of [(3)H]ADO into freshly dissociated CSM cells or endothelium-denuded rings was linear and concentration dependent. Kinetic analysis yielded a maximum uptake (V(max)) of 67 +/- 7.0 pmol. mg protein(-1). min(-1) and a Michaelis constant (K(m)) of 10. 5 +/- 5.8 microM in isolated cells and a V(max) of 5.1 +/- 0.5 pmol. min(-1). mg wet wt(-1) and a K(m) of 17.6 +/- 2.6 microM in intact rings. NBTI inhibited transport into small arteries (IC(50) = 42 nM) and cells. Analyses of extracellular space and diffusion kinetics using [(3)H]sucrose indicate the V(max) and K(m) for ADO transport are sufficient to clear a significant amount of extracellular adenosine. These data indicate CSM possess a high-affinity nucleoside transporter and that the activity of this transporter is sufficient to modulate ADO sensitivity of large and small coronary arteries. (+info)A1 adenosine receptors inhibit multiple voltage-gated Ca2+ channel subtypes in acutely isolated rat basolateral amygdala neurons. (8/208)
1. The anticonvulsant properties of 2-chloroadenosine (CADO) in the basolateral amygdala rely on the activation of adenosine-specific heptahelical receptors. We have utilized whole-cell voltage-clamp electrophysiology to examine the modulatory effects of CADO and other adenosine receptor agonists on voltage-gated calcium channels in dissociated basolateral amygdala neurons. 2. CADO, adenosine, and the A1 subtype-selective agonists N6-(L-2-Phenylisopropyl)adenosine (R-PIA) and 2-chloro-N6-cyclopentyladenosine (CCPA) reversibly modulated whole cell Ba2+ currents in a concentration-dependent fashion. CADO inhibition of barium currents was also sensitive to the A1 antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX). 3. The A2A-selective agonist 4-[2-[[6-Amino-9-(N-ethyl-beta-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl ]benzenepropanoic acid (CGS21680) was without effect. 4. CADO inhibition was predominantly voltage-dependent and sensitive to the sulphydryl-modifying reagent N:-ethylmaleimide, implicating a membrane-delimited, G(i/o)-coupled signal transduction pathway in the channel regulation. 5. Using Ca2+ channel subtype-selective antagonists, CADO inhibition appeared to target multiple channel subtypes, with the inhibition of omega-conotoxin GVIA-sensitive calcium channels being more prominent. 6. Our results indicate that the anti-convulsant effects CADO in the basolateral amygdala may be mediated, in part, by the A1 receptor-dependent inhibition of voltage gated calcium channels. (+info)
The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the | Beneficial Effects of RAF...
2-Chloroadenosine prevents inhibition of H+-coupled dipeptide transport by E.coli STa enterotoxin in Caco-2 epithelia.<...
Plus it
Browsing Department of Medicine Faculty: Research and Presentations by Issue Date
JoVE Author Search: Bache RJ
DNA, RNA and Protein Synthesis - Cell Metabolism
Hart Health Strategies
4-Nitrophenyl β-D-N,N,N-triacetylchitotriose - Creative Enzymes
TESTING, TESTING, 1,2,3…: AQHA 5-panel testing and what it is used for | TSLN.com
The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability - Full Text View - ClinicalTrials.gov
Plus it
The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability
- Yonsei University
Effects of Deliberate Hypotension on Vital Organs | Anesthesiology | ASA Publications
Copland CDA 825 review | What Hi-Fi?
Eczema Skin Allergic Symptoms | Dr Batras™ UAE
Determination of adenosine effects and adenosine receptors in murine corpus cavernosum<...
Human erythrocytes: a possible tool for identification of adenosine analogs of chemotherapeutic potential<...
Rep. Anthony Weiner (D-N.Y.) pauses during a news conference in New York on Monday, after acknowledging inappropriate online...
Relieved and Recovered: Meningioma - Culicchia Neurological Clinic
PERRICONE MD Chloro Plasma - Space.NK - GBP
2016 Global and Chinese 2 Chloro 3 3 3 trifluoropropene CAS 2730 62 3 Industry Market
iAH Search interface 2.4 - Results of the search |page 1|
Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts
Cyclic AMP-binding capacities and histone kinase activation in subcellular components of neocortical tissue. Differential...
Comparison of the inhibition of insulin release by activation of adenosine and α2-adrenergic receptors in rat β-cells |...
Adenosine kinase inhibitors. 4. 6,8-Disubstituted purine nucle...
Export Data and Price of N Methyl 4 Chloro Piperidine | www.eximpulse.com
Cladribine
Mono Chloro Phenol Exporters Manufacturers Suppliers in Mehsana
Methanaminium,N-[chloro[[chloro(cyclohexylimino)methyl]cyclohexylamino]methylene]-N-methyl-, chloride (CAS No. 61740-88-3)...
1-[4-Chloro(<sup>2</sup>H<sub>4</sub>)phenyl](<sup>2</sup>H<sub...
MTP Compressed: Partisan divisions remain on impeachment as House Dems draft articles
BPA highlights letter of biomass support from Congress to EPA | Biomassmagazine.com
Senate Weighs Carbon Incentives For Private Forests - Law360
2010 April Archive - Capitol Confidential - page 8
V-chip bill in Senate - Variety
Top House Democrat calls on Franken to resign - POLITICO
Medicare for All gets new boost from high-ranking House Dem |...
Alterations in cyclic AMP generation and G protein subunits following transient ischemia in gerbil hippocampus<...
L-PIA - What does L-PIA stand for? The Free Dictionary
The Innovation Studio Made This Introvert Uncomfortable in a Good Way
Mono Chloro Benzene,Mono Chloro Benzene Chemical,Monochlorobenzene Exporters
Mono Chloro Phenol Manufacturer,Mono Chloro Phenol Supplier and Exporter Faridabad India
Import Data And Price Of Mono Chloro Benzene | www.eximpulse.com
Lords Chloro Alkali Company History - Business Standard News | Page 1
Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine: A nationwide survey in...
British Library EThOS: A neuropharmcological study of some aspects of carotid body chemoreceptor activity in the cat
Hairy Cell Leukemia Treatment (PDQ )
Para Chloro Phenol in Abhayapuri, Top 10 Para Chloro Phenol Abhayapuri
Anti-Gun Lawmakers Push Ammunition Sales Ban Kickeez On Monday, Ju...
3 Chloro Propiophenone (Cas Number-936-59-4)(34841-35-5) at Latest Price In Goa - Manufacturer,Exporter & Supplier,India
4 Chloro 4 Hydroxybenzophenone (Cas No 42019-78-3) at Latest Price In Goa - Manufacturer,Exporter & Supplier,India
LITURGICZNY CZAS BOŻEGO NARODZENIA - Spontaneous Match
Chloro (triphenylphophine) gold(I): CAS No. 14243-64-2 | Colonial Metal INC
Sen. Schumer Calls Comey Firing Suspect, a Big Mistake | Newsmax.com
L.A. Mayor Eric Garcetti to progressives: Dont make winning the argument more important than progress
Candidates hope to replicate Ocasio-Cortezs tactics across the country
Politics - The American Vision
As Robert Wolf said today, This was cringe worthy. - Sic Semper Tyrannis
Streptomyces rishiriensis
Charousová, Ivana; Javoreková, Soňa; Wink, Joachim (2 February 2015). "Isolation and characterization of Streptomyces ... Streptomyces rishiriensis produces coumermycin A1, notomycin, 2-chloroadenosine, phosphophenylalanarginine and lactonamycin. ...
List of MeSH codes (D13)
2-chloroadenosine MeSH D13.570.583.138.300.200 - cladribine MeSH D13.570.583.138.325 - deoxyadenosines MeSH D13.570.583.138. ... 2-chloroadenosine MeSH D13.570.800.096.300.200 - cladribine MeSH D13.570.800.096.500 - isopentenyladenosine MeSH D13.570. ...
IMSEAR at SEARO: Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.
CONCLUSION: Our study shows that single agent 2-CDA is active and well-tolerated in children with relapsed or refractory LCH.. ... AIM: To evaluate the efficacy and toxicity profile of 2-CDA in children with relapsed or refractory LCH. SETTING AND DESIGN: ... RESULTS: After a median of six courses of cladribine (range, 2 to 9), two (33%) patients achieved PR and two (33%) patients ... Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience. Indian Journal of Cancer. ...
IMSEAR at SEARO: Search
Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.. Biswas, G; Khadwal, A; ...
IMSEAR at SEARO: Search
Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.. Biswas, G; Khadwal, A; ...
IMSEAR at SEARO: Search
Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.. Biswas, G; Khadwal, A; ...
IMSEAR at SEARO: Search
Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.. Biswas, G; Khadwal, A; ...
IMSEAR at SEARO: Search
Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.. Biswas, G; Khadwal, A; ...
IMSEAR at SEARO: Search
Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.. Biswas, G; Khadwal, A; ...
Streptomyces rishiriensis - Wikipedia
Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells |...
2. Adenosine analogues showing the following rank order of potency in the CHO.A2B4 cells (pD2 value): 5-N- ... 10 fold stimulation of cyclic AMP), while, in comparison, maximal responses to adenosine (32% NECA response), 2-chloroadenosine ... 2-(4-aminophenyl)-ethylamino)adenosine (APNEA, 4.06). The purportedly A2A-selective agonist, CGS 21680, failed to elicit a ... ethylcarboxamidoadenosine (NECA, 5.91) , adenosine (5.69) , 2-chloroadenosine (5.27) , N6-( ...
Plus it
8-chloro-adenosine. RT. reverse transcription. PCR. polymerase chain reaction. GAPDH. glyceraldehyde-3-phosphate dehydrogenase ... 8-Chloro-adenosine (8-Cl-Ado), currently in clinical trials, inhibits bioenergy production, mRNA transcription, and protein ... Journal of Pharmacology and Experimental Therapeutics November 1, 2011, 339 (2) 545-554; DOI: https://doi.org/10.1124/jpet. ... Journal of Pharmacology and Experimental Therapeutics November 1, 2011, 339 (2) 545-554; DOI: https://doi.org/10.1124/jpet. ...
Phyllis Gardner's Profile | Stanford Profiles
INHIBITION BY SK-AND-F-96365 OF CA2+ CURRENT, IL-2 PRODUCTION AND ACTIVATION IN T-LYMPHOCYTES BRITISH JOURNAL OF PHARMACOLOGY ... INTERLEUKIN-2 TRANSCRIPTIONAL BLOCK BY MULTIFUNCTIONAL CA2+/CALMODULIN KINASE NATURE Nghiem, P., OLLICK, T., Gardner, P., ... Secretion of interferon-gamma, IL-2, and IL-4 was comparable in CF and control TCC after both forms of activation, while IL-5 ... 2. SK&F 96365 also inhibits [3H]-thymidine incorporation and interleukin-2 (IL-2) synthesis in peripheral blood lymphocytes. 3 ...
Andre Terzic - Research output - Mayo Clinic
López, J. R., Gonzalez, M. A., Rojas, B., López, J. R. & Terzic, A., Feb 18 1995, In: The Lancet. 345, 8947, p. 424-425 2 p.. ... Li, X., Campbell, K. A., Biendarra, S. M., Terzic, A. & Nelson, T. J., Mar 1 2016, In: Genomics Data. 7, p. 129-130 2 p.. ... Arrell, D. K., Zlatkovic Lindor, J., Yamada, S. & Terzic, A., May 1 2011, In: Cardiovascular research. 90, 2, p. 258-266 9 p.. ... Sattiraju, S., Reyes, S., Kane, G. C. & Terzic, A., Feb 2008, In: Clinical pharmacology and therapeutics. 83, 2, p. 354-357 4 p ...
Cat. No.
8- Chloroadenosine- 3, 5- monophosphorothioate, Rp- isomer ( Rp-8-Cl-cAMPS ), sodium salt ... Chloroadenosine- 3, 5- cyclic monophosphorothioate, Rp- isomer ( Rp-2-Cl-cAMPS ), sodium salt ... Rp-8-Br-2-O-MB-cAMPS. 8- Bromo- 2- O- monobutyryladenosine- 3, 5- cyclic monophosphorothioate, Rp- isomer ( Rp-8-Br-2-O-MB ... Rp-2-O-MB-cAMPS. 2- O- Monobutyryladenosine- 3, 5- cyclic monophosphorothioate, Rp- isomer ( Rp-2-O-MB-cAMPS ), sodium ...
Find Research outputs - The University of Aberdeen Research Portal
2-nerves for bicategories. Lack, S. & Paoli, S., Jan 2008, In: K-Theory. 38, 2, p. 153-175 23 p.. Research output: Contribution ... 2-Benzoylspiro[1H-isoindole-1,3-isochromene]-1,3,4(2H,3H)-trione.. Howie, R. A., McSweeney, N., Pratt, A. C., Creaven, B. S ... 2-Bromo-1,3-bis(4-chlorophenyl)prop-2en-1-one. Harrison, W. T. A., Al-Arique, Q. N. M. H., Narayana, B., Yathirajan, H. S. & ... 2-lodo-N-(4-nitrophenyl)benzamide forms hydrogen-bonded sheets of R44 (24) rings. Garden, S. J., Glidewell, C., Skakle, J. M. S ...
Find Research outputs - The University of Aberdeen Research Portal
2-Benzoylspiro[1H-isoindole-1,3-isochromene]-1,3,4(2H,3H)-trione.. Howie, R. A., McSweeney, N., Pratt, A. C., Creaven, B. S ... 2-Bromo-1,3-bis(4-chlorophenyl)prop-2en-1-one. Harrison, W. T. A., Al-Arique, Q. N. M. H., Narayana, B., Yathirajan, H. S. & ... 2-lodo-N-(4-nitrophenyl)benzamide forms hydrogen-bonded sheets of R44 (24) rings. Garden, S. J., Glidewell, C., Skakle, J. M. S ... Avenell, A., Bolland, M. J. & Grey, A., 1 Mar 2019, In: Annals of Clinical Biochemistry. 56, 2, p. 188-189 2 p.. Research ...
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT price,buy 8-CHLOROADENOSINE-3',5'-CYCLIC...
8-CHLOROADENOSINE-3,5-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Suppliers Directory - Find a 8-CHLOROADENOSINE-3,5 ... buy 8-CHLOROADENOSINE-3,5-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT,8-CHLOROADENOSINE-3,5-CYCLIC ... 8-CHLOROADENOSINE-3,5-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT price, ... 8-CHLOROADENOSINE-3,5-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT. $499.75 - $812 ...
David Horne, Ph.D. | City of Hope
8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia. Journal of Cellular Physiology 2019, 234, 16295-16303. ... Synergy of Venetoclax and 8-Chloro-Adenosine in AML: The Interplay of rRNA Inhibition and Fatty Acid Metabolism. Cancers 2022, ... 2-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76. Molecular Carcinogenesis ... Nature Cell Biology 2022, 24(2), 205-216.. *Singhal SS, Mohanty A, Kulkarni P, Horne D, Awasthi S, Salgia R. RLIP depletion ...
IMSEAR at SEARO: Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience.
CONCLUSION: Our study shows that single agent 2-CDA is active and well-tolerated in children with relapsed or refractory LCH.. ... AIM: To evaluate the efficacy and toxicity profile of 2-CDA in children with relapsed or refractory LCH. SETTING AND DESIGN: ... RESULTS: After a median of six courses of cladribine (range, 2 to 9), two (33%) patients achieved PR and two (33%) patients ... Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience. Indian Journal of Cancer. ...
Susanna M.O. Hourani - Publications
PMID 3816951 DOI: 10.1016/0014-2999(86)90521-2 0.695. 1986. Welford LA, Cusack NJ, Hourani SM. ATP analogues and the guinea-pig ... PMID 12088840 DOI: 10.1016/S0006-8993(02)02536-2 0.651. 2001. Hourani SM, Boon K, Fooks HM, Prentice DJ. Role of cyclic ... PMID 7926584 DOI: 10.1016/0306-3623(94)90190-2 0.478. 1994. Lewis CD, Hourani SM, Long CJ, Collis MG. Characterization of ... Adenosine 5-(2-fluorodiphosphate) is a selective agonist at P2-purinoceptors mediating relaxation of smooth muscle. European ...
Lefteris Zacharia - Research output
- UNIC | Research Portal
Dubey, R. K., Gillespie, D. G., Zacharia, L. C., Mi, Z. & Jackson, E. K., 2001, In: Hypertension. 37, 2 II, p. 716-721 6 p.. ... Dubey, R. K., Gillespie, D. G., Zacharia, L. C., Rosselli, M., Imthurn, B. & Jackson, E. K., 2002, In: Hypertension. 39, 2 II, ... Dubey, R. K., Gillespie, D. G., Keller, P. J., Imthurn, B., Zacharia, L. C. & Jackson, E. K., 2002, In: Hypertension. 39, 2 II ... Zacharia, L. C., Jackson, E. K., Gillespie, D. G. & Dubey, R. K., 2001, In: Hypertension. 37, 2 II, p. 658-662 5 p.. Research ...
Shang Hai MEG Biochemical Co.,Ltd - China Suppliers & Manufacturers
CAPRI, MIRIAM
Anti-beta 2 glycoprotein I antibodies in centenarians.. 2004-01-01 Meroni P.L.; Mari D.; Monti D.; Coppola R.; Capri M.; ... Anti-beta 2 glycoprotein I antibodies in centenarians. Meroni P.L.; Mari D.; Monti D.; Coppola R.; Capri M.; Salvioli S.; ... Actin cytoskeleton as a target for 2-chloro adenosine: Evidence for induction of apoptosis in C2C12 myoblastic cells Rufini S ... Actin cytoskeleton as a target for 2-chloro adenosine: Evidence for induction of apoptosis in C2C12 myoblastic cells. ...
Influence of adenosine receptor blockade on renal function and renal autoregulation
Pharmacological classification of adenosine receptors in the sinoatrial and atrioventricular nodes of the guinea-pig
2 A formal comparison of the agonist and antagonist potency data was made by fitting the data to a straight line using a least ... 2-phenylaminoadenosine (CV 1808) and N6-aminoadenosine ... read more (MeAdo). Adenosine and/or NECA curves were obtained in the ... 2-furany1)-5,6- dihydro-l ,2,4-triazolo[1,5-c]quinazolin-5-imine (CGS 15943) and N6-(endonorbornan-2-yl)-9-methyladenine (N- ... 2-phenylisopropyl)adenosine (R-PIA), N6-cycJohexyladenosine (CHA), 2-chloroadenosine (CADO),),S( + )-W-(2-phenylisopropyl) ...
Supplementary Materials1 - Structural Basis of IL-1 Family Cytokine Signaling
2. Methods and Materials 2.1. Mouse maintenance and genotyping Mutant mice had been crossed as previously defined (Broders- ... We show right here that ENCCs exhibit the supplement C3aR which the anaphylatoxin 2-Chloroadenosine (CADO) C3a exists in gut ... Young et 2-Chloroadenosine (CADO) al., 2014). ENCCs may therefore be considered to be a populace of cells migrating ... and directionality of 2-Chloroadenosine (CADO) migration, via an N-cadherin-dependent procedure. ...
AB680 | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
GPR17; IP3R1; Kir6.1; P2X1; P2X2; P2X3; P2X4; P2X5; P2X6; P2X7; P2Y11 receptor; P2Y13 receptor; P2Y1 receptor; P2Y2 receptor; ... Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 2; AcetylCoA transporter; acetyl-CoA acetyltransferase 1; ... P2Y12 receptor; P2Y13 receptor; P2Y2 receptor; P2Y4 receptor ...
Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X...
2E), we detected the presence of puncta within the shaft of the dendrite that were not observed in cells expressing either ... 2F). In summary, these results suggest that neither catalytic activity nor an intact IQ motif or coiled-coil domain is ... 2B), mCherry-BRAG1 was found in prominent puncta distributed along the length of dendrites, where it clearly colocalized with ... Figure 2. BRAG1 mutants localize to excitatory synapses in hippocampal neurons. A, Dissociated rat hippocampal neurons were ...
Volume 53 Issue 2 | Cancer Research | American Association for Cancer Research
TXNIP Antikörper
Macer-Wright, Sileikaite, Rayner, Hawkins: "8-Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and ... Tbp-2 Antikörper. TBP2 Antikörper. THIF Antikörper. Trf3 Antikörper. TRF3 Antikörper. txnip Antikörper. VDUP1 Antikörper. Vdup1 ... TATA box binding protein like 2 (Tbpl2) Antikörper. TATA-box binding protein like 2 (TBPL2) Antikörper. thioredoxin interacting ...
Santec Chem Corp @ ChemBuyersGuide.com, Inc.
2-METHYL-3-FURANTHIOL ACETATE. CAS:55764-25-5 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ETHYL ESTER-1,1-DIOXIDE. CAS ... 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC METHYL ESTER-1,1-DIOXIDE. CAS:35511-15-0 ... 4-METHOXYPHENYL 2,3,4,6-TETRA-O-ACETYL-SS-D-GALACTOPYRANOSIDE. CAS:2872-65-3 ... DL-2,3-DIMERCAPTO-1-PROPANESULFONIC ACID SODIUM SALT MONOHYDRATE. CAS:207233-91-8 ...
安公乸球罗竔-欞迋您
Ethyl 2,4-dioxovalerate. (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl.... 1-(Benzo[d][1,3]dioxol-5-yl)propan-1-one ... 2.Peptides. 2.1. Dipeptides ,tripeptides ,Tetrapeptides & Other Short Peptides 2.2. Peptides 2.3. Poly Amino Acids 3.Resins For ... 2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,.... *¥0.00 ... 2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,.... *¥0.00 ...
Isopentenyladenosine | Profiles RNS
Copyright© Thomas Jefferson University. All Rights Reserved.. The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff ...
Stomatognathic system. Medical search. Website summaries
She worked for 2 years at Orchard Cove Orthopedic Rehabilitation. Sharlene has been able to gain experience as an intern at LDS ... 2.) Janet cahill applied psychology program the purpose of this study was … 1.7 Managing bipolar disorder in adults in the ... Rabbit incisors grow 1.5-2 mm per week and depend on many hours per day of constant attrition on tough fibrous vegetation to ... They are typically held at community or maternal and child health centres and run by a MEND 2-4 trained program leader. Child ...
Browsing by Subject "3111 Biomedicine"
8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia Buettner, Ralf; Le Xuan Truong Nguyen; Kumar, Bijender; ... The reagent 8-chloro-adenosine (8-Cl-Ado) is a ribose-containing, RNA-directed nucleoside analog that is incorporated into ... We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P ... He has his pocket picked deftly by a small hand while gawping [2]. ...
Adenosine5
- N6-(2-(4-aminophenyl)-ethylamino)adenosine (APNEA, 4.06). (garvan.org.au)
- 3. Of these agents, NECA was observed to exhibit the greatest intrinsic activity in CHO.A2B4 cells (ca. 10 fold stimulation of cyclic AMP), while, in comparison, maximal responses to adenosine (32% NECA response), 2-chloroadenosine (61%), and APNEA (73%) were reduced. (garvan.org.au)
- After control measurements, the adenosine receptor antagonist, 1,3-dipropyl-8-p-sulfophenylxanthine (PSPX) was infused intrarenally for 45 min at 2 or 6 μM/min. (uab.edu)
- Adenosine and/or NECA curves were obtained in the absence and presence of the antagonists 8-cyclopentyl-l,3-dipropylxanthine (DPCPX), 9-chloro-2-(2-furany1)-5,6- dihydro-l ,2,4-triazolo[1,5-c]quinazolin-5-imine (CGS 15943) and N6-(endonorbornan-2-yl)-9-methyladenine (N-0861). (uu.nl)
- 8-Chloroadenosine is an adenosine derivative that acts as a ribonucleoside analog following phosphorylation, potentially resulting in inhibition of transcription and decreased cell proliferation (NCI Drug Dictionary). (jax.org)
CADO4
- 2011). The Match pathway is usually highly conserved and plays several unexpected functions in animal development, highlighting its importance for the control of 2-Chloroadenosine (CADO) cell behavior (Leslie and Mayor, 2013). (woodgreenoutreach.org)
- 2004). Isolated cells exhibit an unbiased random walk behavior, while nonsolitary cells or cells in chains are more directional and progress caudally (Young et 2-Chloroadenosine (CADO) al. (woodgreenoutreach.org)
- We show right here that ENCCs exhibit the supplement C3aR which the anaphylatoxin 2-Chloroadenosine (CADO) C3a exists in gut and in cultured gut explants. (woodgreenoutreach.org)
- We also discovered that C3a/C3aR inhibitors disturbed the migratory stores and neuronal network company through the ENCC colonization from the embryonic gut, their cohesiveness, co-attraction, and directionality of 2-Chloroadenosine (CADO) migration, via an N-cadherin-dependent procedure. (woodgreenoutreach.org)
Responses1
- The vasoconstrictor responses to bolus injections of 2-chloroadenosine (100 μmol) were attenuated by 58 and 86% during the low and high doses of PSPX and to a lesser extent with aminophylline/theophylline infusions. (uab.edu)
Potency1
- 2 A formal comparison of the agonist and antagonist potency data was made by fitting the data to a straight line using a least squares procedure based on principal components analysis to account for the variance on both axes. (uu.nl)
Cell1
- IMSEAR at SEARO: Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience. (who.int)
Inhibition4
- 2-Chloroadenosine prevents inhibition of H+-coupled dipeptide transport by E.coli STa enterotoxin in Caco-2 epithelia. (elsevier.com)
- 7. Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia. (nih.gov)
- 12. Targeting Apoptosis in Acute Myeloid Leukemia: Current Status and Future Directions of BCL-2 Inhibition with Venetoclax and Beyond. (nih.gov)
- 17. Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia. (nih.gov)
NECA2
- Again, 2-chloroadenosine and NECA reduced IL-beta-induced TNF-alpha production more potently than CPA. (maastrichtuniversity.nl)
- Furthermore, only 2-chloroadenosine, but not NECA, strongly inhibited cytokine-induced IL-6 and IL-8 production. (maastrichtuniversity.nl)
Cyclic1
- 8-Chloroadenosine 3′:5′-monophosphate (8ClcAMP) inhibits the growth of human glioma cell lines at much lower concentrations than more commonly used cyclic AMP analogues, without inducing morphological differentiation. (aacrjournals.org)
Venetoclax4
- 1. A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). (nih.gov)
- 2. Abivertinib synergistically strengthens the anti-leukemia activity of venetoclax in acute myeloid leukemia in a BTK-dependent manner. (nih.gov)
- 3. Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models. (nih.gov)
- 6. 225Ac-labeled CD33-targeting antibody reverses resistance to Bcl-2 inhibitor venetoclax in acute myeloid leukemia models. (nih.gov)
Apoptosis1
- 5. Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. (nih.gov)
Purine1
- 2-Chlorodeoxyadenosine is a simple purine nucleoside that has previously been shown to be effective in the treatment of low-grade malignant disorders of lymphoid tissue, including chronic lymphocytic leukemia and non-Hodgkin's lymphoma. (nih.gov)
Human1
- 8-Chloroadenosine, one of the metabolites, inhibited the proliferation of WF human glioma cells more potently than 8ClcAMP. (aacrjournals.org)
Significantly1
- The proportion of cervical cancer cases positive for HSV-2 infection was significantly greater than that of non-cervical cancer cases and matched control women. (nih.gov)
Cells2
- Opiate-treated cells have higher basal-, prostaglandin E-, and 9-chloroadenosine-stimulated activities than do control cells. (nih.gov)
- MATERIALS AND METHODS The source of each chemical, growth conditions for culturing neuroblastoma X glioma NG108-15 hybrid cells, and prepa- ration of homogenates have been described (2). (nih.gov)
Patients1
- The patients received 2-chlorodeoxyadenosine (0.1 mg per kilogram of body weight per day) by continuous infusion for seven days. (nih.gov)
Effect1
- We concluded that 8ClcAMP exerts its growth-inhibitory effect through its active metabolite 8-chloroadenosine. (aacrjournals.org)
Higher1
- The administration of 2-chlorodeoxyadenosine resulted in a higher rate of complete remission than is observed with interferon alfa, and it required no maintenance therapy. (nih.gov)
Products1
- Key products include ADP, ATP disodium salt and 2'-Deoxyguanosine monohydrate. (glentham.com)