2-Acetylaminofluorene
Hydroxyacetylaminofluorene
Acetoxyacetylaminofluorene
Carcinogens
Liver
DNA Adducts
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
gamma-Glutamyltransferase
Precancerous Conditions
Mutagens
Benzopyrene Hydroxylase
p-Dimethylaminoazobenzene
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Benzo(a)pyrene
Microsomes, Liver
Lipotropic Agents
4-Hydroxyaminoquinoline-1-oxide
Aldrin
Benzopyrenes
Rats, Inbred Strains
Polydeoxyribonucleotides
DNA Repair
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Aminobiphenyl Compounds
Sulfuric Acids
Mutagenicity Tests
Hydroxylation
Amines
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Puerto Rico
An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)
Soil
Public Health
Questionnaires
Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. (1/450)
Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans are predisposed to cancers in other tissues associated with exposure to environmental carcinogens. To test the importance of nucleotide excision repair in protection against chemical carcinogenesis in internal organs, we treated XPC mutant (XPC-/-) mice with 2-acetylaminofluorene and NOH-2-acetylaminofluorene. We observed a significantly higher incidence of chemically induced liver and lung tumors in XPC-/- mice compared with normal and heterozygous littermates In addition, the progression of liver tumors in XPC-/- Trp53+/- mice is accelerated compared with XPC-/- Trp53+/+ animals. Finally, we demonstrate a higher incidence of spontaneous testicular tumors in XPC-/- TrpS3-/- double mutant mice compared with XPC+/+ Trp53-/- mice. (+info)Pseudoenzymatic reduction of N-hydroxy-2-acetylaminofluorene to 2-acetylaminofluorene mediated by cytochrome P450. (2/450)
N-hydroxy-2-acetylaminofluorene (N-OH-AAF) was reduced to 2-acetylaminofluorene by rat liver microsomes in the presence of both NAD(P)H and FAD under anaerobic conditions. The microsomal reduction proceeds as if it were an enzymatic reaction. However, when the microsomes were boiled, the activity was not abolished, but was enhanced. The activity was also observed with cytochrome P450 2B1 alone, without NADPH-cytochrome P450 reductase, in the presence of these cofactors. Hematin also exhibited a significant reducing activity in the presence of both a reduced pyridine nucleotide and FAD. The activities of microsomes, cytochrome P450 2B1 and hematin were also observed upon the addition of photochemically reduced FAD instead of both NAD(P)H and FAD. The microsomal reduction of N-OH-AAF appears to be a non-enzymatic reaction by the reduced flavin, catalyzed by the heme group of cytochrome P450. (+info)Effect of detergents on the N-and ring-hydroxylation of 2-acetamidofluorene by hamster liver microsomal preparations. (3/450)
Effects of detergents such as cholate, deoxycholate and Triton X-100 were studied on N-and ring-hydroxylation of 2-acetamidofluorene by reconstituted and unresolved microsomal systems from livers of hamsters pretreated with 3-methylcholanthrene. Triton X-100 (2.5 mg/nmol of cytochrome P-448) inhibited N-and ring-hydroxylation by wholemicrosomal preparations by 40 and 90% respectively Deoxycholate at the same concentration inhibited both hydroxylations completely, whereas cholate inhibited N-and ring-hydroxylation by 40 and 50% respectively. In reconstitution studies, the presence of Triton X-100(0.5-1.0mg/nmol of cytochrome P-448) along with unsolubilized cytochrome P-448 fraction and solubilized reductase fraction increased N-hydroxylation to an appreciable extent compared with ring-hydroxylation. Both cholate and deoxycholate at 0.5-1.0 mg concentrations had a greater stimulatory effect on ring-than on N-hydroxylation activity in such a reconstituted system. (+info)Bone marrow as a potential source of hepatic oval cells. (4/450)
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability. (+info)Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats. (5/450)
Previously, we have shown that Copenhagen (Cop) rats are highly resistant to the induction of putative preneoplastic, glutathione S-transferase 7-7 (GST 7-7)-positive liver lesions following treatment with a modified resistant hepatocyte protocol. The objective of the current study was to establish the time course for the development of resistance and examine potential resistance mechanisms in Cop rats using F344 rats as susceptible controls. Male Cop and F344 rats (n = 25), 7-8 weeks of age, were initiated with diethylnitrosamine (200 mg/kg) and promoted 3 weeks later with four doses of 2-acetylaminofluorene (20 mg/kg) and a 2/3 partial hepatectomy (PH). Groups of rats from each strain were killed on days 2, 4, 7, 14 and 21 post-PH, 2 h after receiving bromodeoxyuridine. Cop livers contained similar numbers of GST 7-7-positive lesions to F344 livers on days 2 and 4 post-PH. The percent volume of liver occupied by these lesions did not differ between the strains on days 2, 4 and 7 post-PH. On day 14, however, approximately 29% of the liver volume in F344 rats was occupied by lesions, whereas in Cop rats this was significantly less (approximately 9%, P < 0.001). On day 21, lesions occupied approximately 58% of F344 rat livers and only approximately 6% of Cop livers. Despite these differences, the labeling index of hepatocytes was not significantly different between the strains at any time point, either within lesions or within surrounding normal liver. Furthermore, the apoptotic indices were not different between the strains at any time. However, differences were found in the extent of lesion remodeling (redifferentiation) and in the pattern of oval cell response following PH in Cop livers. By day 14 post-PH, approximately 76% of Cop liver lesions showed evidence of remodeling, compared with only approximately 14% of F344 lesions. The oval cell response to PH was equivalent in the two strains up to day 4 post-PH but by day 7, in F344 livers there was extensive migration of these cells into the liver parenchyma, whereas in Cop livers, the response remained localized to the portal regions. These results suggest that Cop resistance occurs at the promotion stage and not the initiation stage of carcinogenesis. Resistance appears not to be due to a lower proliferation rate nor to a higher apoptotic rate within Cop lesions. Precocious remodeling and/or a diminished oval cell response, however, may contribute to the resistance of Cop rats to the growth of GST 7-7-positive hepatic lesions. (+info)Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain. (6/450)
Loss of heterozygosity (LOH) at specific chromosomal regions is a frequent event in poorly differentiated human hepatocellular carcinomas (HCCs), but rare in mouse HCCs. This behavior could depend on interspecies differences in mechanisms of hepatocarcinogenesis or in developmental stage of lesions. To verify if LOH is involved in rat hepatocarcinogenesis, we studied LOH frequency in slowly growing neoplastic nodules induced by Solt-Farber model in diethylnitrosamine-initiated BFF1 rats. We analyzed, with microsatellites, markers at 67 rat loci dispersed over all chromosomes, corresponding to regions homologous to those lost in human HCCs or containing hepatocellular susceptibility (Hcs) or resistance (Hcr) loci in rat and mouse. In agreement with previous findings with mouse HCCs, but at variance with human HCCs, no detectable LOH was found at any locus in rats, suggesting rare LOH involvement in neoplastic nodules, with low tendency to progress to full malignancy, of BFF1 rats. (+info)Development of resistance during the early stages of experimental liver carcinogenesis. (7/450)
The present study was designed to determine whether the resistant phenotype is acquired at the initiated cell stage itself or requires further exposure to a promoting regimen to express resistance. Male Fischer 344 rats were initiated with diethylnitrosamine (DENA) (200 mg/kg i.p.) and were subjected to either no further treatment or to the resistant hepatocyte (RH) model of liver tumor promotion. Six weeks later, the resistance of the focal lesions generated in these two groups to the mitoinhibitory effects of 2-acetylaminofluorene (2-AAF) was determined by subjecting the rats to two-thirds partial hepatectomy (PH) in the presence of a mitoinhibitory dose of 2-AAF (5 mg/kg i.p.) given at the time of PH. Labeling index was determined by administering multiple injections of [(3)H]thymidine. All rats were killed 48 h post-PH. While only a small percentage (23%) of the glutathione S-transferase-positive foci generated by DENA in the absence of an exogenous liver tumor promoting regimen were resistant to the mitoinhibitory effects of 2-AAF, a majority (85%) of the foci became resistant to 2-AAF following exposure to the RH model of liver tumor promotion. Further, initiated rats exposed to either 2-AAF or to CCl(4) alone, the two components of the RH model, resulted in 71% of the foci being resistant to the mitoinhibitory effects of 2-AAF. Similar patterns of results were obtained when the resistance of the foci to the mitoinhibitory effects of orotic acid, a liver tumor promoter and an inhibitor of DNA synthesis in normal hepatocytes, was monitored. These results suggest that the majority of initiated hepatocytes are not of resistant phenotype, however, they have acquired a unique ability to express resistance upon exposure to certain agents such as 2-AAF and CCl(4) or to a promoting regimen such as the RH model of liver tumor promotion. (+info)Modulation of the gene network connected to interferon-gamma in liver regeneration from oval cells. (8/450)
Suppression subtractive hybridization was used to clone genes associated with proliferation of oval cells in rat liver regenerating after a 70% partial hepatectomy combined with the feeding of 2-acetylaminofluorene. A subset of the identified genes comprised interferon-gamma receptor alpha subunit (IFN-gammaRalpha), gp91phox, interleukin-1beta (IL-1beta), lymphocyte function-associated molecule-1alpha (LFA-1), eukaryotic initiation factor-2-associated 67-kd protein (eIF-2-associated 67-kd protein), and alpha-fetoprotein, which constitute part of the cellular program modulated by IFN-gamma. Therefore, expression analysis performed by Northern blotting and immunohistochemistry were extended to include IFN-gamma, the IFN-gamma receptor beta subunit (IFN-gammaRbeta), three secondary response genes induced by interaction of IFN-gamma with IFN-gamma receptor complexes, ie, IL-1beta-converting enzyme (ICE), intercellular adhesion molecule-1 (ICAM-1), and urokinase-type plasminogen activator receptor (uPAR), and a cytokine inducing IFN-gamma expression, ie, interleukin-18 (IL-18). The Northern blot analysis showed that all examined genes were modulated when progenitor-like oval cells were activated and recruited for liver regeneration. Immunohistochemistry localized the subunits of the IFN-gamma receptor complex, IFN-gammaRalpha and IFN-gammaRbeta, the secondary response genes uPAR and ICAM-1, the IFN-gamma-inducing factor IL-18, and ICE to the ductular structures of oval cells. In contrast, during liver regeneration after a 70% partial hepatectomy, only modulation of IL-1beta and ICE was observed. Our results, therefore, indicate that IFN-gamma-mediated events may be particularly important when cells in the bile ductules must respond to liver damage by production of ductular oval cells. (+info)
Monitoring the exposure of rats to 2-acetylaminofluorene by the estimation of mu :: TNO Repository
Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development - Wu - 2012 ...
Quantitative analysis of the ring-hydroxylated metabolites of 2-fluorenylacetamide by gas-liquid chromatography.
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Solanum nigrum
L. Extract Inhibits 2-Acetylaminofluorene-Induced Hepatocarcinogenesis through Overexpression of Glutathione...
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Determining if Something Is a Carcinogen
Ames test
Examples include tris(2,3-dibromopropyl)phosphate, which was used as a flame retardant in plastic and textiles such as ... ISBN 978-0-7099-1044-2. Hakura A, Suzuki S, Satoh T (January 1999). "Advantage of the use of human liver S9 in the Ames test". ... 455 (1-2): 29-60. doi:10.1016/S0027-5107(00)00064-6. PMID 11113466. Charnley G (2002). "Ames Test". Encyclopedia of Public ... 46 (1-2): 41-4. doi:10.1007/BF00361244. PMID 7235997. S2CID 23769437. Phillipson, Caroline E.; Ioannides, Costas (1989-03-01 ...
SULT1C2
129 (1-2): 141-70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739. Glatt H, Boeing H, Engelke CE, Ma L, Kuhlow A, Pabel U, ... 482 (1-2): 27-40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246. Kiehlbauch CC, Lam YF, Ringer DP (August 1995). " ... 65 (2): 157-65. doi:10.1006/geno.2000.6150. PMID 10783263. "Entrez Gene: SULT1C1 sulfotransferase family, cytosolic, 1C, member ... v t e (Genes on human chromosome 2, CS1: long volume value, All stub articles, Human chromosome 2 gene stubs). ...
Acetoxyacetylaminofluorene
... is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis. ...
Hydroxyacetylaminofluorene
... is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis. ...
Emmanuel Farber
3.0.CO;2-1. PMID 3167785. S2CID 35730301. 1988 Gelderblom, W.C.A.; Semple, E.; Marasas, W.F.O.; Farber, E. (1992). "The cancer- ... 605 (2): 149-166. doi:10.1016/0304-419X(80)90002-5. PMID 6994812. Solt, D. B.; Cayama, E.; Tsuda, H.; Enomoto, K.; Lee, G.; ... 2. Marcel Dekker. ISBN 0824768388. Faber, E.; Fisher, Murray M., eds. (1980). Toxic Injury of the Liver (Part B). Liver: Normal ... 2. Marcel Dekker. ISBN 0824768396. "Emmanuel Farber, MD, PhD, deceased (1918-2014), Fellow of the Academy of the AACR, Class of ...
Hadacidin
Glycine, formate, and the 2-carbon of serine were all found to be very quickly incorporated into hadacidin during its synthesis ... 1960), who found that N-hydroxy-2-acetylaminofluorene was formed in the intact rat upon administration of 2-acetylaminofluorene ... and the 2-carbon of glycine were incorporated into both the glycyl and formyl portions of the hydroxamate. N-Hydroxyglycine was ...
SULT1C4
129 (1-2): 141-70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739. Glatt H, Boeing H, Engelke CE, et al. (2001). "Human ... 482 (1-2): 27-40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ... 65 (2): 157-65. doi:10.1006/geno.2000.6150. PMID 10783263. Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, ... v t e (Genes on human chromosome 2, CS1: long volume value, All stub articles, Human chromosome 2 gene stubs). ...
2-Aminofluorene
... (2-AF) is a synthetic arylamine. It is a white to tan solid with a melting point of 125-132 °C. 2-AF has only ... In molecular biology, 2-AF is able to induce frameshift mutations, by deleting 2 bases in the DNA. DNA is able to undergo a ... In other species, 2-AF was also the cause of mutations in the host genome. The leukocytes, in particular, were able to uptake ... 2-Acetylaminofluorene is able to cause tumors in mice and other animals in the liver and kidney. This substance can act as a ...
N-hydroxy-2-acetamidofluorene reductase
The systematic name of this enzyme class is 2-acetamidofluorene:NAD(P)+ oxidoreductase. Other names in common use include N- ... In enzymology, a N-hydroxy-2-acetamidofluorene reductase (EC 1.7.1.12) is an enzyme that catalyzes the chemical reaction 2- ... Gutmann HR, Erickson RR (1969). "The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver ... Kitamura S, Tatsumi K (1985). "Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol". Biochem. ...
Antineoplastic resistance
3.0.co;2-s. ISSN 0020-7136. PMID 10225454. Youn, Cha-Kyung; Kim, Mi-Hwa; Cho, Hyun-Ju; et al. (2004-07-15). "Oncogenic H-Ras Up ... 320 (2): 493-500. doi:10.1016/j.bbrc.2004.06.003. PMID 15219856. Miyashita, T; Reed, JC (January 1, 1993). "Bcl-2 oncoprotein ... 14 (2): 158-168. doi:10.3109/07357909609018891. ISSN 0735-7907. PMID 8597901. Conze, D.; Weiss, L.; Regen, P. S.; et al. (2001- ... Other genes involved in the apoptotic pathway related drug resistance include h-ras and bcl-2/bax. Oncogenic h-ras has been ...
Mutagen
2-Acetylaminofluorene, originally used as a pesticide but may also be found in cooked meat, may cause cancer of the bladder, ... 3.0.CO;2-#. PMID 11013390. "Calabrese says mistake led to adopting the LNT model in toxicology". phys.org. 2017. Archived from ... Retrieved 2 Jul 2010. Callaway, E (2008). "Skin-tone gene could predict cancer risk". New Scientist. Archived from the original ... August 2005). "Cyclooxygenase-2-mediated DNA damage". The Journal of Biological Chemistry. 280 (31): 28337-46. doi:10.1074/jbc. ...
Aromatic-hydroxylamine O-acetyltransferase
... and N-hydroxy-2-acetylaminofluorene N-O acyltransferase. Bartsch H, Dworkin C, Miller EC, Miller JA (1973). "Formation of ...
List of MeSH codes (D02)
... vitamin k 2 MeSH D02.455.849.291.523.500.922 - vitamin k 3 MeSH D02.455.849.291.850 - taxoids MeSH D02.455.849.291.850.777 - ... 5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 - fanft MeSH D02.640.600.308 - furagin MeSH D02.640.600.313 - ... 2-ethyl 2-(4-nitrophenyl) ester MeSH D02.705.539.783 - phorate MeSH D02.705.539.790 - phosmet MeSH D02.705.539.900 - temefos ... 2-ethyl 2-(4-nitrophenyl) ester MeSH D02.886.309.783 - phorate MeSH D02.886.309.790 - phosmet MeSH D02.886.309.900 - temefos ...
AAF
... a filter used to restrict the bandwidth of a signal 2-Acetylaminofluorene, a biochemical tool Alien Ant Farm, an alternative ...
List of MeSH codes (D04)
... vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1-naphthylamine MeSH D04.615.638.845.800 - ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 - fusidic acid MeSH D04.808.247.808.607 - lanosterol MeSH D04.808.247.808.756 - ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... 25-hydroxyvitamin d 2 MeSH D04.808.247.222.537 - ergosterol MeSH D04.808.247.222.857 - sitosterols MeSH D04.808.247.808 - ...
2-Acetylaminofluorene
2-AAF is a substrate for cytochrome P-450 (CYP) enzyme, which is a part of a super family found in almost all organisms. This ... 2-Acetylaminofluorene (AAF, 2-AAF) is a carcinogenic and mutagenic derivative of fluorene. It is used as a biochemical tool in ... The interconversion of amide and amine metabolites of 2-AAF can further occur via the microsomal enzyme deacetylase producing ... The reactive nitrenium, carbonium and arylamidonium ion metabolites of 2-AAF react with the nucleophilic groups in DNA, ...
Ati - Wikipédia
"Coffee and type 2 diabetes: from beans to beta-cells". Department of Nutrition, Harvard School of Public Health; van Dam RM. ... 2. Role of growth factors and cytokines in hepatic regeneration". Department of Pathology and Laboratory Medicine, Brown ... "Coffee consumption and risk for type 2 diabetes mellitus". Harvard School of Public Health, Channing Laboratory, Harvard ... Lobus ati kawangun saka sèl parenkimal lan sèl non-parenkimal.[2] Sèl parenkimal ing ati diarani hepatosit, manggoni watara 80 ...
NIOSHTIC-2 Search Results - Basic View
Advanced Search Search Help About NIOSHTIC-2 Feedback Terms: pesticide or pesticides or insecticide or insecticides or ... NIOSHTIC-2 Publications Search. Search Results. New Search. ...
Occupational Health Guidelines for Chemical Hazards (81-123) | NIOSH | CDC
2-Acetylaminofluorene. 53-96-3. 0007.pdf pdf icon. No Revision. Acetylene tetrabromide. 79-27-6. 0009.pdf pdf icon. 0009-rev. ... 2-Aminopyridine. 504-29-0. 0026.pdf pdf icon. 0026-rev.pdf pdf icon. ... 2-Butoxyethanol. 111-76-2. 0070.pdf pdf icon. 0070-rev.pdf pdf icon. ... Dimethyl-1,2-dibromo-2,2-dichlorethyl phosphate. 300-76-5. 0225.pdf pdf icon. No Revision. ...
NIOSHTIC-2 Search Results - Full View
The hazardous substances included in this report were: 2-acetylaminofluorene (53963), acrylonitrile (107131), aldrin (309002), ... di-2-ethylhexyl-phthalate (117817), 4- dimethylaminoazobenzene (60117), 1,1-dimethylhydrazine (57147), ethylene-dichloride ( ... 2-pentanone (107879), phenylhydrazine (100630), beta-propiolactone (57578), tetramethyl-succinonitrile (3333526), toluene- ...
NIOSHTIC-2 Search Results - Basic View
Advanced Search Search Help About NIOSHTIC-2 Feedback Terms: pesticide or pesticides or insecticide or insecticides or ... NIOSHTIC-2 Publications Search. Search Results. New Search. ...
NIOSHTIC-2 Search Results - Basic View
Advanced Search Search Help About NIOSHTIC-2 Feedback Terms: pesticide or pesticides or insecticide or insecticides or ... NIOSHTIC-2 Publications Search. Search Results. New Search. ...
Occupational Cancer - Carcinogen List | NIOSH | CDC
1,2,3-Trichloropropane. U-Z. Uranium, insoluble compounds Uranium, soluble compounds. Vinyl bromide; class, vinyl halides. ... 2,4-Diaminoanisoleo. o-Dianisidine-based dyes. 1,2-Dibromo-3-chloropropane (DBCP). Dichloroacetylene. p-Dichlorobenzene. 3,3′- ... 1,1,2,2-Tetrachloroethane. Tetrachloroethylene. Titanium dioxide. o-Tolidine-based dyes. o-Tolidine. Toluene diisocyanate (TDI) ... 2-Acetylaminofluorene. Acrylamide. Acrylonitrile. Aldrin. 4-Aminodiphenyl. Amitrole. Aniline and homologs. o-Anisidine. Arsenic ...
NIOSHTIC-2 Search Results - Full View
... acetylaminofluorene (53963) (AAF) formation by high pressure liquid chromatography. NOHAAF was rapidly metabolized by cytosolic ... At 2 hours, the amount of AAF was 45 percent of the original amount of NOHAAF. Only 25 percent of the initially added NOHGAF ... No further decrease in NOHGAF was observed in up to 2 hours of incubation. The results indicated that NOHGAF inhibited its own ... The cytosolic metabolism of 2-aminofluorene (153786) (AF) derivatives was studied in liver microsomal fractions obtained from ...
RTECS:AB9450000 - Acetamide, N-fluoren-2-yl- - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
Acetylaminofluorene. Azetylaminofluoren (German). FAA. N-2-Fluorenylacetamide. N-9H-Fluoren-2-ylacetamide. N-Acetyl-2- ... Acetylamino)fluorene. 2AAF. 2-AAF. 2-Acetamidofluorene. 2-Acetaminofluorene. 2-Acetylamino-fluoren (German). 2- ... Acetylaminofluorene. 2-Acetylaminofluorene (OSHA). 2-FAA. 2-Fluorenylacetamide. AAF. Acetamide, N-9H-fluoren-2-yl- (9CI). ... 2 µmol/L/16H (+enzymatic activation step). EMMUEG 46,126,2005. mutation in microorganisms. /Salmonella typhimurium. 1.1 µmol/L/ ...
NIOSHTIC-2 Search Results - Basic View
Irreversible inhibition of the cytosolic metabolism of N-hydroxy-2-acetylaminofluorene by its glycolyl analog. ...
NIOSHTIC-2 Search Results - Full View
The hazardous substances included in this report were: 2-acetylaminofluorene (53963), acrylonitrile (107131), aldrin (309002), ... di-2-ethylhexyl-phthalate (117817), 4- dimethylaminoazobenzene (60117), 1,1-dimethylhydrazine (57147), ethylene-dichloride ( ... 2-pentanone (107879), phenylhydrazine (100630), beta-propiolactone (57578), tetramethyl-succinonitrile (3333526), toluene- ...
NIOSHTIC-2 Search Results - Full View
The hazardous substances included in this report were: 2-acetylaminofluorene (53963), acrylonitrile (107131), aldrin (309002), ... di-2-ethylhexyl-phthalate (117817), 4- dimethylaminoazobenzene (60117), 1,1-dimethylhydrazine (57147), ethylene-dichloride ( ... 2-pentanone (107879), phenylhydrazine (100630), beta-propiolactone (57578), tetramethyl-succinonitrile (3333526), toluene- ...
IMSEAR at SEARO: Mutagenicity and anti-mutagenicity of selected spices.
Asafoetida and turmetic extract were found to inhibit microsomal activation dependent mutagenicity of 2-acetamidofluorene. ...
Acetylaminofluorene, 2- (2005-110) | NIOSH | CDC
Acetylaminofluorene, 2- Specific Medical Tests or Examinations Published in the Literature for OSHA-Regulated Substances ... Acetylaminofluorene, 2-. CAS No: 53-96-3. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references ... Acetylaminofluorene, 2-. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene | CiNii Research
ATSDR-PHA-HC-Isla de Vieques Bombing Range, Vieques, Puerto Rico
Florida Tanks (2). Florida. Public water supply tank owned by PRASA. Puerto Rico DOH. June 1999a. ... Table B-2.. Sampling Summary of Groundwater Wells on Isla de Vieques, Puerto Rico. Name. Location. Use. Sampling Agency. ... Well 2-3. Martineau. Remote well used by the public when water supply is interrupted. United States Environmental Protection ... 4-A-DNT was not measured directly, but was considered by Hoffsommer and Glover (1978) to be present at the same levels as 2-A- ...
Occupational Chemical Database | Occupational Safety and Health Administration
2-AMINO-2-METHYLPROPANOL 124-68-5 *A615. AMP; 2-aminodimethylethanol; β -aminoisobutanol; 2-amino-2-methylpropan-1-ol; 2-amino- ... 309-00-2 *0125. 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-endo-1,4-exo-5,8-dimethanonaphthalene; HHDN; octalene; Seedrin ... ortho-aminoanisole; 2-anisidine; o-methoxyaniline [Note: o-anisidine has been used as a basis for many dyes.]; para- ... lasso; acetanilide, 2 - chloro-2,6-diethyl-N-(methoxymethyl); 2-chloro-N-(2,6-diethylphenyl) N-(methoxymethyl) acetamide; ...
Understanding the ancillary ligand effect on luminescent cyclometalated Ir(III) complex as a reporter for 2-acetylaminofluorene...
N-2-acetylaminofluorene (AAF) generates different mutational outcomes when placed at G1, G2, and G3 of a NarI sequence (- ... Here, we report the synthesis of three cyclometalated [Ir(L)2dppz]+ complexes (L = 2-phenylpyridine (ppy) 1; benzo[h]quinoline ... Understanding the ancillary ligand effect on luminescent cyclometalated Ir(III) complex as a reporter for 2-acetylaminofluorene ... Remarkably, complexes 1 and 2 displayed dominant 3LC transition characteristic of polar environment despite binding to the ...
Environment and Breast Cancer: Science Review | Silent Spring Institute
Registration Dossier - ECHA
2-acetylaminofluorene. Untreated negative controls:. yes. Negative solvent / vehicle controls:. yes. Positive controls:. yes. ... 2 (reliable with restrictions). Rationale for reliability incl. deficiencies:. guideline study. Cross-reference. Reason / ... 2 (reliable with restrictions). Rationale for reliability incl. deficiencies:. guideline study. Justification for type of ... Trisodium 5-[[4-chloro-6-(ethylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(2-sulphonatophenyl)azo]naphthalene-2,7- ...
Rule 3745-114-01 - Ohio Administrative Code | Ohio Laws
NIOSHTIC-2 Search Results - Full View
Proposition 65 List of Elabscience Chemicals
Bis(2-chloro-1-methylethyl)ether, technical grade - Toxicity: cancer. *Bitumens, extracts of steam-refined and air refined - ... 1,4-Dichloro-2-butene - 764-41-0 - Toxicity: cancer. *3,3-Dichloro-4,4-diamino-diphenyl ether - 28434-86-8 - Toxicity: cancer ... 1-Amino-2-methylanthraquinone - 82-28-0 - Toxicity: cancer. *2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole - 712-68-5 - ... Bis(2-chloroethyl)ether - 111-44-4 - Toxicity: cancer. *N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) - 494-03-1 - ...
Fluoride Action Network | Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and...
PDF] Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated...
Search Whole Repository | CURVE
Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver | Journal of Pharmacology and Experimental...
2). No MRP3 protein was detectable in two livers (with log MRP3 mRNA/β-actin being −5.7 and −5.2; see Fig. 1). In the remainder ... 2. We observed the previously described pattern of two bands, a possible result of different levels of glycosylation (König et ... Figure 2 MRP3 protein expression in human livers. A representative Western blot shows variable MRP3 expression in seven nucleus ... 2000) Characterization of the 5′-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in ...
Words with A C D E F N O T U
2 28-letter words with a c d e f n o t u:. * deoxynucleotidyltransferases ... The anion SiPh,sub,3,/sub,F,sub,2,/sub,-; its tetrabutylammonium salt is used in organic synt.... ... A bromochlorodifluoromethane is a haloalkane with the chemical formula CF,sub,2,/sub,ClBr, used in fire extinguishers. ... A hydroxyacetylaminofluorene is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis ...
Reactome | Homologues of SULT1A1 [cytosol]
Toonmate Premium Lean-Back Lounge Seat, Right Side | Overton's
Find Research outputs - Taipei Medical University
... acetylaminofluorene: A Direct‐acting Carcinogen Inducing Hepatocellular Carcinoma in Sprague‐Dawley Rats. Ho, YS. S. & Lin, JK ... Chen, H. M., Chen, R. J., Fang, J. F. & Wang, C. C., 1994, In: Chang Gung Medical Journal. 17, 2, p. 163-167 5 p.. Research ... Wang, L. M., Yang, H. C., Hwang, J. H., Mou, C. Y. & Horng, H. E., Feb 2 1994, In: Physica B: Condensed Matter. 194-196, PART 2 ... Chen, H. I., Kang, B. H., Wang, J. Y. & Tseng, Y. L., May 23 1994, In: Neuroscience Letters. 173, 1-2, p. 181-184 4 p.. ...
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.705.400.140.175 2,4,5-Trichlorophenoxyacetic Acid D2.241.511.316.881 D2.241.81.18.386.682.800 D2.241.511.316.682.800 2,4- ... 2-Ethyl 2-(4-Nitrophenyl) Ester D2.705.539.750 D2.705.429.812.750 D2.886.309.750 D2.705.539.692.750 D2.886.300.846.750 ... D2.241.81.18.110.80 2-Hydroxy-5-nitrobenzyl Bromide D2.755.566.400 D2.455.426.559.389.657.566.400 2-Methyl-4- ... Replaced for 2012 by Sialic Acid Binding Ig-like Lectin 2) Antigua and Barbuda Z1.639.880.50 Argininosuccinic Acid D2.241. ...
Evidence for the lack of hepatic n-acetyltransferase in suncus (Suncus murinus)<...
When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ... When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ... When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ... When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ...
Faculty of Pharmacy - Research output - Keio University
Oda, S., Sugai, T. & Ohta, H., 2001, In: Chemistry Letters. 6, p. 500-501 2 p.. Research output: Contribution to journal › ... Mashino, T., Okuda, K., Hirota, T., Hirobe, M., Nagano, T. & Mochizuki, M., 2001, In: Fullerene Science and Technology. 9, 2, p ... Satoh, M., Mashino, T., Nagano, T., Hirobe, M., Takayanagi, I. & Koike, K., 2001, In: Fullerene Science and Technology. 9, 2, p ... Oda, S., Sugai, T. & Ohta, H., 2001 Jan 1, In: Journal of Bioscience and Bioengineering. 91, 2, p. 202-207 6 p.. Research ...
DeCS
Acetylaminofluorene. Aminofluorene AAF. Fluoren 2 ylacetamide. Fluoren-2-ylacetamide. N 2 Fluorenylacetamide. N Acetyl 2 ... 2-Acetylaminofluorene - Preferred Concept UI. M0023186. Scope note. A hepatic carcinogen whose mechanism of activation involves ... 83; was ACETYLAMINOFLUORENE 1980-82; was ACETYLAMINOFLUORENE see under FLUORENES 1975-79. ... 83; was ACETYLAMINOFLUORENE 1980-82; was ACETYLAMINOFLUORENE see under FLUORENES 1975-79. ...
OBITUARIES 2014 | NIH Intramural Research Program
Robert E. Cooke (died on February 2, 2014, at 93), a pediatrician, was a member of President John F. Kennedys presidential ... James Bahre (died on October 2, 2014, at 73) provided scientific instruments for NIH medical researchers, working first for ... contributing pioneering work on the mechanism of the carcinogen 2-acetylaminofluorene. He established a research program in ...
Find Research outputs - NYU Scholars
LeDoux, J. E., Iwata, J., Pearl, D. & Reis, D. J., Apr 23 1986, In: Brain Research. 371, 2, p. 395-399 5 p.. Research output: ... Wellman, P. J., Arasteh, K., Ruddle, J. L. & Strickland, M. D., Jul 1986, In: Brain Research Bulletin. 17, 1, p. 127-128 2 p.. ... Uleman, J. S. & Weston, M., Jul 1986, In: Sex Roles. 15, 1-2, p. 43-62 20 p.. Research output: Contribution to journal › ... Hout, M. & Jackson, J. A., Sep 1986, In: European Sociological Review. 2, 2, p. 114-137 24 p.. Research output: Contribution to ...
IMSEAR at SEARO: Mutagenicity and anti-mutagenicity of selected spices.
Section 7412 - Hazardous air pollutants, 42 U.S.C. § 7412 | Casetext Search + Citator
2) Coke oven production technology study. (A) The Secretary of the Department of Energy and the Administrator shall jointly ... 2) Construction, reconstruction and modifications. (A) After the effective date of a permit program under subchapter V in any ... 2) Failure to promulgate a standard. In the event that the Administrator fails to promulgate a standard for a category or ... 2) Emission standards. (A) If Congress does not act on any recommendation submitted under paragraph (1), the Administrator ...
Human POSTN/OSF-2 (Periostin) ELISA Kit | G-EC-04031 | Gentaur Elisa Kits
Human POSTN/OSF-2 (Periostin) ELISA Kit from Gentaur Elisa Kits. Cat Number: G-EC-04031. USA, UK & Europe Distribution. ... QuicKey Pro Human POSTN/OSF-2 (Periostin) ELISA Kit , G-EC-06109 ... Human POSTN/OSF-2 (Periostin) ELISA Kit , G-EC-04031. Rating * ... Storage: An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the ... Target Synonym: OSF2, PDLPOSTN, PN, RP11-412K4.1, Osteoblast Specific Factor 2. Tested Sample Types: Serum, plasma and other ...
Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats<...
keywords = "2-acetylaminofluorene, Antioxidant, Diethylnitrosamine, Liver cancer, Sodium selenite",. author = "Jamaludin ... 2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group ... 2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group ... 2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group ...
DeCS Ingl s
N-Acetoxy-2-acetylaminofluorene .. N-Acetoxy-N-acetyl-2-aminofluorene .. N Acetoxy 2 acetylaminofluorene .. N Acetoxy N acetyl ... D04.615.389.050 2-Acetylaminofluorene .. D04.615.389.050.060 Acetoxyacetylaminofluorene .. D10 Lipids .. D10.251 Fatty Acids . ... D02.065.064.150 2-Acetylaminofluorene .. D02.065.064.150.100 Acetoxyacetylaminofluorene .. D02.065.199 Anilides .. D02.065. ... D02.241.081.018.110.080 2-Acetylaminofluorene .. D02.241.081.018.110.080.070 Acetoxyacetylaminofluorene .. D02.355 Ethers .. ...
ArylamineRatsMetaboliteMammaryLiverAdductsDerivativeDeletionDetectionCompounds1996EnzymeVitroStrainsMethodsModelAflatoxinsReferencesOppositeCellsHeadings53963AcetaldehydePlatensisSodiumAcidHemolysinSupplPyruvateApoptosisToxicityEvaluationPhosphorylationTissuesComplicationsMethodsChapterExpressionGroupCenterStressJournalActivityTest
Arylamine2
- Reference: Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. (neb.com)
- The C8- and N 2-G adducts derived from 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) were placed at the G1 and G3 sites of the NarI sequence, in which the G3 site is an established hot spot for frameshift mutation with the model arylamine derivative 2-acetylaminofluorene but G1 is not. (neb.com)
Rats5
- The abilities of liver cytosol fractions from the suncus and Sprague-Dawley (SD) rats to N-acetylate aniline, p-aminobenzoic acid, p-aminosalicylic acid and 2-aminofluorene (AF) were compared. (elsevier.com)
- When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not detectable in serum, whereas the metabolite was seen clearly in rats. (elsevier.com)
- This study emphasizes the role of selenium on oxidative stress in experimental rats with N-diethylnitrosamine (DEN) initiated and 2-acetylaminofluorene (2-AAF) promoted multistage hepatocellular carcinogenesis (HCC). (elsevier.com)
- Rats were divided randomly into six groups: negative control, positive control (DEN+2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group (DEN+post-SSE 12 weeks) and therapeutic control (respective control for therapeutic group). (elsevier.com)
- Methods Rats were treated with 2-acetylaminofluorene and carbon tetrachloride to establish the models of hepatic oval cells, two-step collagenase perfusion technique and flow cytometry sorting were used to separate and purify oval cells, and cell culture and amplification were performed. (shsmu.edu.cn)
Metabolite1
- The enzyme preferentially glucuronidated the N-hydroxy metabolite of 2-acetylaminofluorene and was more active towards the 6- and 12-hydroxylated metabolites of benzo[α]pyrene. (edu.au)
Mammary1
- Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells. (nih.gov)
Liver1
- Oval cells in cases like this have been thought to be facultative liver organ stem cells with the capacity of differentiating into both hepatocytes and bile duct epithelial cells.1 2 The relevant query of the foundation of oval cells continues to be open up. (conferencedequebec.org)
Adducts3
- In 1-base incorporation studies, pol eta inserted C and A, pol iota inserted T, and pol kappa inserted G. Steady-state kinetic parameters were measured for these dNTPs opposite the C8- and N 2-IQ adducts at both sites, being most favorable for pol eta. (neb.com)
- Thus, the pol eta products yielded frame-shifts with the N 2 but not the C8 IQ adducts. (neb.com)
- The model carcinogen N-2-acetylaminofluorene covalently binds to the C8 position of guanine to form two adducts, the N-(2'-deoxyguanosine-8-yl)-aminofluorene (G-AF) and the N-2-(2'-deoxyguanosine-8-yl)-acetylaminofluorene (G-AAF). (cnrs.fr)
Derivative1
- A hydroxyacetylaminofluorene is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis. (joueb.com)
Deletion2
- Detection and characterization of spontaneous and N-2- acetylaminofluorene-induced deletion mutations. (carleton.ca)
- With the G3 N 2-IQ adduct, a -2 deletion occurred at the site of the adduct. (neb.com)
Detection3
- Single gene detection with a procedure using 2-acetylaminofluorene (AFF)-modified probes, immunoperoxidase cytochemistry and reflection-contrast microscopy is reported. (semanticscholar.org)
- Then a biotinylated detection antibody specific for Human POSTN/OSF-2 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (caslab.com)
- Only those wells that contain Human POSTN/OSF-2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. (caslab.com)
Compounds1
- Based on these results, the RSMN assay is considered sufficiently validated to establish it as a 'tier 2' assay for dermally exposed compounds and was recently accepted into the OECD's test guideline development program. (mattek.com)
19961
- Since 1996, the inci- and 2 other genetic markers, toxRS having slightly different Not I patterns dence of V . parahaemolyticus infec- and orf8 (1,3). (cdc.gov)
Enzyme1
- Moreover, retinoids induced CYP3A4 enzyme activity in HepG2 human hepatoma and Caco-2 human colorectal adenocarcinoma cells. (scite.ai)
Vitro1
- This ELISA kit applies to the in vitro quantitative determination of Human POSTN/OSF-2 concentrations in Serum, plasma and other biological fluids. (caslab.com)
Strains1
- seafood-associated bacterial gastroen- the virulence-associated hemolysins, With the exception of the strain teritis in the world, often associated thermostable-direct hemolysin, and belonging to the old O3:K6 clone, the with the consumption of raw or under- thermostatable-related hemolysin (2), PFGE-typeable O3:K6 strains, despite cooked seafood. (cdc.gov)
Methods1
- Even after these methods were developed, and even after various guidelines were developed by various regulatory agencies in the United States, they were often not observed (2, 3, 7, 9, 10). (cdc.gov)
Model1
- Lucas, P and Horton, BJ, Guidelines for treatment of lice in sheep with long wool based on a model of the development of wool damage , Australian Veterinary Journal, 92, (1-2) pp. 8-14. (edu.au)
Aflatoxins1
- Giacomini et al, Animal Health, 2, Investigations into the presence of aflatoxins in human body fluids and tissues in relation to child health in the tropics. (kentyapi.info)
References1
- 2) NIOSH references include diagnostic, screening, and other tests. (cdc.gov)
Opposite1
- With the G1 N 2-IQ adduct, the product was error-free at the site opposite the base and then stalled. (neb.com)
Cells2
- UGT1A3, when expressed in COS cells has a relative molecular mass of 55 kDa and is active in the glucuronidation of estrone and 2-hydroxyestrone. (edu.au)
- Yet in some circumstances where hepatocyte replication can be suppressed such as for example after treatment with 2-acetylaminofluorene (2AAF) oval cells will proliferate and differentiate to replenish the hepatic mass. (conferencedequebec.org)
Headings1
- Concentrations for 20 substances were listed under the headings: (1) Rapidly fatal to man and animals, (2) Dangerous in 0.51 h, (3) 0.51 h without serious disturbances, and (4) Only minimal symptoms observed (3). (cdc.gov)
539631
- Mononuclear leukocytes (MNL) metabolized AF to its acetylated form 2-acetylaminofluorene (53963) (AAF). (cdc.gov)
Acetaldehyde1
- WARNING: This product can expose you to chemicals including Acetaldehyde / 2-Acetylaminofluorene, Bracken fern, which is [are] known to the State of California to cause cancer. (overtons.com)
Platensis2
- To study the effect of C-Phycocyanin (C-PC), a biliprotein isolated from Spirulina platensis, on 2-acetylaminofluorene (2-AAF) induced oxidative stress and MDR1 expression in the liver of albino mice. (nih.gov)
- Holman, B and Kashani, A and Malau-Aduli, AEO, Wool quality traits of purebred and crossbred Merino lambs orally drenched with Spirulina ( Arthrospira platensis ) , Italian Journal of Animal Science, 13, (2) pp. 387-391. (edu.au)
Sodium1
- Solvents used: sterile, redistilled water (for the test substance and sodium azide reference substance solution) and DMSO (for 2-aminoanthracene and 4-nitro-o-phenylendiamine reference solutions). (europa.eu)
Acid1
- 10. The ink composition of claim 8, wherein at least one of the first or second vinyl chloride-vinyl acetate resins includes from 0.1 wt % to 2 wt % of dicarbonic acid. (freepatentsonline.com)
Hemolysin2
- seafood-associated bacterial gastroen- the virulence-associated hemolysins, With the exception of the strain teritis in the world, often associated thermostable-direct hemolysin, and belonging to the old O3:K6 clone, the with the consumption of raw or under- thermostatable-related hemolysin (2), PFGE-typeable O3:K6 strains, despite cooked seafood. (cdc.gov)
- All isolates were characterized by polymerase chain reaction (PCR) to detect the genes encoding the virulence-associated hemolysins, thermostable-direct hemolysin, and thermostatable-related hemolysin ( 2 ), and 2 other genetic markers, toxRS and orf8 ( 1 , 3 ). (cdc.gov)
Suppl1
- 2 , 1 Suppl. (elsevier.com)
Pyruvate1
- An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (uams.edu)
Apoptosis1
- 2. Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. (nih.gov)
Toxicity1
- 1,2-Dithiole-3-thione was a less effective inhibitor and exhibited both a systemic toxicity and genotoxicity in alveolar macrophages, whereas its substituted analogue Oltipraz showed limited protective effects in this model. (aacrjournals.org)
Evaluation2
- Linear regression evaluation was performed to calculate em R /em 2 of DNA quantification dimension methods in comparison to ddPCR outcomes. (bioxorio.com)
- Open up in another window Amount 2 Evaluation of cfDNA concentrations in matched bloodstream examples in four different BCTs. (bioxorio.com)
Phosphorylation2
- Co-administration of C-PC and 2-AAF inhibited the expression of MDR1 by preventing ROS generation, Akt phosphorylation and NF-kappaB nuclear translocation. (nih.gov)
- 2012). On the other hand, the manifestation of interleukin-1 and cyclooxygenase-2 in microglial cells from also advertised the phosphorylation of NF-B-inhibitory subunit p50 at S337 as well as the nuclear build up of NF-B (Russo et al. (bio-aromatica.com)
Tissues1
- PB treatment of animals with DEN/AAF-induced nodules greatly increased P450 2B1/2 expression in surrounding tissues, whereas most, but not all, nodules were not inducible. (nih.gov)
Complications1
- Atorsan is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors. (medsonline365.us)
Methods1
- Even after these methods were developed, and even after various guidelines were developed by various regulatory agencies in the United States, they were often not observed (2, 3, 7, 9, 10). (cdc.gov)
Chapter1
- Part 2 · Chapter 12. (who.int)
Expression2
- 2-AAF treatment resulted in upregulation of MDR1 expression and enhanced the generation of reactive oxygen species (ROS). (nih.gov)
- To examine this hypothesis further, hepatic hyperplastic nodules were produced with AFB (10 ip doses of AFB, 150 micrograms/kg/day, followed by partial hepatectomy) or by a modified Solt-Farber protocol (DEN/AAF), and the effects of PB on nodule growth and expression of cytochrome(s) P450 2B1 and/or P450 2B2 (P450 2B1/2) were determined. (nih.gov)
Group2
- The first group was treated with the vehicle (absolute alcohol), the second group was treated with C-PC (50 mg/kg body weight), the third group was treated with 2-AAF (25 mg/kg body weight) and the fourth group was treated with C-PC (50 mg/kg body weight) and 2-AAF, daily for 3 days. (nih.gov)
- 2. The ink composition of claim 1, further comprising at least one additive selected from the group of surfactants, wetting agents, dispersants, leveling agents, and preservatives. (freepatentsonline.com)
Center1
- This was a headquarter position at level of Senior Director (level Executive Committee +2), reporting to the Vice President, Global Center for Scientific Affairs (scientific body across all therapeutic areas). (ous-research.no)
Stress2
Journal1
- Lucas, P and Horton, BJ, Guidelines for treatment of lice in sheep with long wool based on a model of the development of wool damage , Australian Veterinary Journal, 92, (1-2) pp. 8-14. (edu.au)
Activity1
- Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). (nih.gov)
Test1
- SETTING UP THE PLATES: 0.1 ml of test solution at each dose level, solvent control, negative control, or reference mutagen solution (positive control) and 0.5 ml of S9 mix (for test with metabolic activation) or S9 mix substitution-buffer (for test without metabolic activation) and 0.1 ml of bacteria suspension and 2 ml of overlay agar were mixed in a test tube and poured onto the selective agar plates. (europa.eu)