AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
2-AcetylaminofluoreneHydroxyacetylaminofluoreneAcetoxyacetylaminofluoreneFluorenesCarcinogensLiver Neoplasms, ExperimentalRats, Inbred F344DiethylnitrosamineLiverDNA AdductsBiotransformationgamma-GlutamyltransferasePrecancerous ConditionsMutagensBenzopyrene Hydroxylasep-DimethylaminoazobenzeneDNANitroanisole O-DemethylaseBenzo(a)pyreneMethyldimethylaminoazobenzeneMicrosomes, LiverHepatectomyLipotropic Agents4-Hydroxyaminoquinoline-1-oxideAldrinBenzopyrenesRats, Inbred StrainsLiver RegenerationDeoxyguanosinePolydeoxyribonucleotidesDNA RepairAminobiphenyl CompoundsSulfuric AcidsMutagenicity TestsHydroxylationDNA ReplicationAminesMethylcholanthreneDNA DamageNitrophenolsPuerto RicoSoilTranslationsPublic HealthTranslatingQuestionnairesHispanic Americans
2-Acetylaminofluorene
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Hydroxyacetylaminofluorene
A N-hydroxylated derivative of 2-ACETYLAMINOFLUORENE that has demonstrated carcinogenic action.
Acetoxyacetylaminofluorene
An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action.
Fluorenes
A family of diphenylenemethane derivatives.
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Liver Neoplasms, Experimental
Experimentally induced tumors of the LIVER.
Rats, Inbred F344
Diethylnitrosamine
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
DNA Adducts
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
gamma-Glutamyltransferase
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
Precancerous Conditions
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Mutagens
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Benzopyrene Hydroxylase
A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC 1.14.14.1.
p-Dimethylaminoazobenzene
A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound "may reasonably be anticipated to be a carcinogen." (Merck, 11th ed)
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Nitroanisole O-Demethylase
Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.
Benzo(a)pyrene
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
Methyldimethylaminoazobenzene
A very potent liver carcinogen.
Microsomes, Liver
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Hepatectomy
Excision of all or part of the liver. (Dorland, 28th ed)
Lipotropic Agents
Endogenous factors or drugs that increase the transport and metabolism of LIPIDS including the synthesis of LIPOPROTEINS by the LIVER and their uptake by extrahepatic tissues.
4-Hydroxyaminoquinoline-1-oxide
A potent mutagen and carcinogen. It is a reduction product of 4-NITROQUINOLINE-1-OXIDE. It binds with nucleic acids and inactivates both bacteria and bacteriophage.
Aldrin
A highly poisonous substance that was formerly used as an insecticide. The manufacture and use has been discontinued in the U.S. (From Merck Index, 11th ed)
Benzopyrenes
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Liver Regeneration
Repair or renewal of hepatic tissue.
Deoxyguanosine
A nucleoside consisting of the base guanine and the sugar deoxyribose.
Polydeoxyribonucleotides
A group of 13 or more deoxyribonucleotides in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
DNA Repair
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Aminobiphenyl Compounds
Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.
Sulfuric Acids
Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.
Mutagenicity Tests
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
Hydroxylation
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
DNA Replication
The process by which a DNA molecule is duplicated.
Amines
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Methylcholanthrene
A carcinogen that is often used in experimental cancer studies.
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Nitrophenols
Puerto Rico
An island in the Greater Antilles in the West Indies. Its capital is San Juan. It is a self-governing commonwealth in union with the United States. It was discovered by Columbus in 1493 but no colonization was attempted until 1508. It belonged to Spain until ceded to the United States in 1898. It became a commonwealth with autonomy in internal affairs in 1952. Columbus named the island San Juan for St. John's Day, the Monday he arrived, and the bay Puerto Rico, rich harbor. The island became Puerto Rico officially in 1932. (From Webster's New Geographical Dictionary, 1988, p987 & Room, Brewer's Dictionary of Names, 1992, p436)
Soil
The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.
Translations
Products resulting from the conversion of one language to another.
Public Health
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
Translating
Conversion from one language to another language.
Questionnaires
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Hispanic Americans
Persons living in the United States of Mexican (MEXICAN AMERICANS), Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans.

Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. (1/450)

Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans are predisposed to cancers in other tissues associated with exposure to environmental carcinogens. To test the importance of nucleotide excision repair in protection against chemical carcinogenesis in internal organs, we treated XPC mutant (XPC-/-) mice with 2-acetylaminofluorene and NOH-2-acetylaminofluorene. We observed a significantly higher incidence of chemically induced liver and lung tumors in XPC-/- mice compared with normal and heterozygous littermates In addition, the progression of liver tumors in XPC-/- Trp53+/- mice is accelerated compared with XPC-/- Trp53+/+ animals. Finally, we demonstrate a higher incidence of spontaneous testicular tumors in XPC-/- TrpS3-/- double mutant mice compared with XPC+/+ Trp53-/- mice.  (+info)

Pseudoenzymatic reduction of N-hydroxy-2-acetylaminofluorene to 2-acetylaminofluorene mediated by cytochrome P450. (2/450)

N-hydroxy-2-acetylaminofluorene (N-OH-AAF) was reduced to 2-acetylaminofluorene by rat liver microsomes in the presence of both NAD(P)H and FAD under anaerobic conditions. The microsomal reduction proceeds as if it were an enzymatic reaction. However, when the microsomes were boiled, the activity was not abolished, but was enhanced. The activity was also observed with cytochrome P450 2B1 alone, without NADPH-cytochrome P450 reductase, in the presence of these cofactors. Hematin also exhibited a significant reducing activity in the presence of both a reduced pyridine nucleotide and FAD. The activities of microsomes, cytochrome P450 2B1 and hematin were also observed upon the addition of photochemically reduced FAD instead of both NAD(P)H and FAD. The microsomal reduction of N-OH-AAF appears to be a non-enzymatic reaction by the reduced flavin, catalyzed by the heme group of cytochrome P450.  (+info)

Effect of detergents on the N-and ring-hydroxylation of 2-acetamidofluorene by hamster liver microsomal preparations. (3/450)

Effects of detergents such as cholate, deoxycholate and Triton X-100 were studied on N-and ring-hydroxylation of 2-acetamidofluorene by reconstituted and unresolved microsomal systems from livers of hamsters pretreated with 3-methylcholanthrene. Triton X-100 (2.5 mg/nmol of cytochrome P-448) inhibited N-and ring-hydroxylation by wholemicrosomal preparations by 40 and 90% respectively Deoxycholate at the same concentration inhibited both hydroxylations completely, whereas cholate inhibited N-and ring-hydroxylation by 40 and 50% respectively. In reconstitution studies, the presence of Triton X-100(0.5-1.0mg/nmol of cytochrome P-448) along with unsolubilized cytochrome P-448 fraction and solubilized reductase fraction increased N-hydroxylation to an appreciable extent compared with ring-hydroxylation. Both cholate and deoxycholate at 0.5-1.0 mg concentrations had a greater stimulatory effect on ring-than on N-hydroxylation activity in such a reconstituted system.  (+info)

Bone marrow as a potential source of hepatic oval cells. (4/450)

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.  (+info)

Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats. (5/450)

Previously, we have shown that Copenhagen (Cop) rats are highly resistant to the induction of putative preneoplastic, glutathione S-transferase 7-7 (GST 7-7)-positive liver lesions following treatment with a modified resistant hepatocyte protocol. The objective of the current study was to establish the time course for the development of resistance and examine potential resistance mechanisms in Cop rats using F344 rats as susceptible controls. Male Cop and F344 rats (n = 25), 7-8 weeks of age, were initiated with diethylnitrosamine (200 mg/kg) and promoted 3 weeks later with four doses of 2-acetylaminofluorene (20 mg/kg) and a 2/3 partial hepatectomy (PH). Groups of rats from each strain were killed on days 2, 4, 7, 14 and 21 post-PH, 2 h after receiving bromodeoxyuridine. Cop livers contained similar numbers of GST 7-7-positive lesions to F344 livers on days 2 and 4 post-PH. The percent volume of liver occupied by these lesions did not differ between the strains on days 2, 4 and 7 post-PH. On day 14, however, approximately 29% of the liver volume in F344 rats was occupied by lesions, whereas in Cop rats this was significantly less (approximately 9%, P < 0.001). On day 21, lesions occupied approximately 58% of F344 rat livers and only approximately 6% of Cop livers. Despite these differences, the labeling index of hepatocytes was not significantly different between the strains at any time point, either within lesions or within surrounding normal liver. Furthermore, the apoptotic indices were not different between the strains at any time. However, differences were found in the extent of lesion remodeling (redifferentiation) and in the pattern of oval cell response following PH in Cop livers. By day 14 post-PH, approximately 76% of Cop liver lesions showed evidence of remodeling, compared with only approximately 14% of F344 lesions. The oval cell response to PH was equivalent in the two strains up to day 4 post-PH but by day 7, in F344 livers there was extensive migration of these cells into the liver parenchyma, whereas in Cop livers, the response remained localized to the portal regions. These results suggest that Cop resistance occurs at the promotion stage and not the initiation stage of carcinogenesis. Resistance appears not to be due to a lower proliferation rate nor to a higher apoptotic rate within Cop lesions. Precocious remodeling and/or a diminished oval cell response, however, may contribute to the resistance of Cop rats to the growth of GST 7-7-positive hepatic lesions.  (+info)

Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain. (6/450)

Loss of heterozygosity (LOH) at specific chromosomal regions is a frequent event in poorly differentiated human hepatocellular carcinomas (HCCs), but rare in mouse HCCs. This behavior could depend on interspecies differences in mechanisms of hepatocarcinogenesis or in developmental stage of lesions. To verify if LOH is involved in rat hepatocarcinogenesis, we studied LOH frequency in slowly growing neoplastic nodules induced by Solt-Farber model in diethylnitrosamine-initiated BFF1 rats. We analyzed, with microsatellites, markers at 67 rat loci dispersed over all chromosomes, corresponding to regions homologous to those lost in human HCCs or containing hepatocellular susceptibility (Hcs) or resistance (Hcr) loci in rat and mouse. In agreement with previous findings with mouse HCCs, but at variance with human HCCs, no detectable LOH was found at any locus in rats, suggesting rare LOH involvement in neoplastic nodules, with low tendency to progress to full malignancy, of BFF1 rats.  (+info)

Development of resistance during the early stages of experimental liver carcinogenesis. (7/450)

The present study was designed to determine whether the resistant phenotype is acquired at the initiated cell stage itself or requires further exposure to a promoting regimen to express resistance. Male Fischer 344 rats were initiated with diethylnitrosamine (DENA) (200 mg/kg i.p.) and were subjected to either no further treatment or to the resistant hepatocyte (RH) model of liver tumor promotion. Six weeks later, the resistance of the focal lesions generated in these two groups to the mitoinhibitory effects of 2-acetylaminofluorene (2-AAF) was determined by subjecting the rats to two-thirds partial hepatectomy (PH) in the presence of a mitoinhibitory dose of 2-AAF (5 mg/kg i.p.) given at the time of PH. Labeling index was determined by administering multiple injections of [(3)H]thymidine. All rats were killed 48 h post-PH. While only a small percentage (23%) of the glutathione S-transferase-positive foci generated by DENA in the absence of an exogenous liver tumor promoting regimen were resistant to the mitoinhibitory effects of 2-AAF, a majority (85%) of the foci became resistant to 2-AAF following exposure to the RH model of liver tumor promotion. Further, initiated rats exposed to either 2-AAF or to CCl(4) alone, the two components of the RH model, resulted in 71% of the foci being resistant to the mitoinhibitory effects of 2-AAF. Similar patterns of results were obtained when the resistance of the foci to the mitoinhibitory effects of orotic acid, a liver tumor promoter and an inhibitor of DNA synthesis in normal hepatocytes, was monitored. These results suggest that the majority of initiated hepatocytes are not of resistant phenotype, however, they have acquired a unique ability to express resistance upon exposure to certain agents such as 2-AAF and CCl(4) or to a promoting regimen such as the RH model of liver tumor promotion.  (+info)

Modulation of the gene network connected to interferon-gamma in liver regeneration from oval cells. (8/450)

Suppression subtractive hybridization was used to clone genes associated with proliferation of oval cells in rat liver regenerating after a 70% partial hepatectomy combined with the feeding of 2-acetylaminofluorene. A subset of the identified genes comprised interferon-gamma receptor alpha subunit (IFN-gammaRalpha), gp91phox, interleukin-1beta (IL-1beta), lymphocyte function-associated molecule-1alpha (LFA-1), eukaryotic initiation factor-2-associated 67-kd protein (eIF-2-associated 67-kd protein), and alpha-fetoprotein, which constitute part of the cellular program modulated by IFN-gamma. Therefore, expression analysis performed by Northern blotting and immunohistochemistry were extended to include IFN-gamma, the IFN-gamma receptor beta subunit (IFN-gammaRbeta), three secondary response genes induced by interaction of IFN-gamma with IFN-gamma receptor complexes, ie, IL-1beta-converting enzyme (ICE), intercellular adhesion molecule-1 (ICAM-1), and urokinase-type plasminogen activator receptor (uPAR), and a cytokine inducing IFN-gamma expression, ie, interleukin-18 (IL-18). The Northern blot analysis showed that all examined genes were modulated when progenitor-like oval cells were activated and recruited for liver regeneration. Immunohistochemistry localized the subunits of the IFN-gamma receptor complex, IFN-gammaRalpha and IFN-gammaRbeta, the secondary response genes uPAR and ICAM-1, the IFN-gamma-inducing factor IL-18, and ICE to the ductular structures of oval cells. In contrast, during liver regeneration after a 70% partial hepatectomy, only modulation of IL-1beta and ICE was observed. Our results, therefore, indicate that IFN-gamma-mediated events may be particularly important when cells in the bile ductules must respond to liver damage by production of ductular oval cells.  (+info)

Monitoring the exposure of rats to 2-acetylaminofluorene by the estimation of mu :: TNO RepositoryMonitoring the exposure of rats to 2-acetylaminofluorene by the estimation of mu :: TNO Repository
The sensitivity of various methods suitable for biomonitoring the exposure to genotoxicants was compared in an animal model. The results were related to the presence of genotoxic effects in the target organ. Groups of male Wistar rats were given one oral dose of 0, 0.1, 1, 10 or 200 mg 2-acetylaminofluorene (2-AAF)/5 ml dimethyl sulphoxide/kg body weight. Peripheral blood cells, excreta, liver and spleen were collected at different time intervals after dosing. Mutagenicity in urine and extracts of faeces was determined using the Ames test with Salmonella typhimurium TA98 with and without S9 and with and without ??-glucuronidase. Genotoxic effects were studied by measuring DNA-adduct formation in lymphocytes, liver and spleen, and sister-chromatid exchanges (SCEs) in lymphocytes. DNA adducts were measured with immunochemical techniques and postlabelling methods. Mutagenecity in urine and faeces, collected during the first 24 h after treatment, was detected at 2-AAF doses of 1 mg/kg b.w. and ...
https://repository.tudelft.nl/view/tno/uuid%3A76353073-f8d7-4709-a23d-f98822e2864c
Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development - Wu - 2012 ...Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development - Wu - 2012 ...
Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the mechanism underlying the progression from cirrhosis to HCC remains unclear. Herein we report the concurrent increase of liver progenitor cells (LPCs) and transforming growth factor-β (TGF-β) in diethylnitrosamine (DEN)-induced rat hepatocarcinogenesis and cirrhotic livers of HCC patients. Using several experimental approaches, including 2-acetylaminofluorene/partial hepatectomy (2-AAF/PHx) and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-elicited murine liver regeneration, we found that activation of LPCs in the absence of TGF-β induction was insufficient to trigger hepatocarcinogenesis. Moreover, a small fraction of LPCs was detected to coexpress tumor initiating cell (T-IC) markers during rat hepatocarcinogenesis and in human HCCs, and TGF-β levels were positively correlated with T-IC marker expression, which indicates a role of TGF-β in T-IC generation. Rat pluripotent LPC-like WB-F344 cells ...
http://onlinelibrary.wiley.com/doi/10.1002/hep.26007/abstract
Quantitative analysis of the ring-hydroxylated metabolites of 2-fluorenylacetamide by gas-liquid chromatography. | DIAL.pr -...Quantitative analysis of the ring-hydroxylated metabolites of 2-fluorenylacetamide by gas-liquid chromatography. | DIAL.pr -...
Batardy-Grégoire, M ; Razzouk, C. ; Evrard, E. ; Roberfroid, Marcel. Quantitative analysis of the ring-hydroxylated metabolites of 2-fluorenylacetamide by gas-liquid chromatography.. In: Analytical biochemistry, Vol. 122, no. 1, p. 199-205 (1982 ...
https://dial.uclouvain.be/pr/boreal/object/boreal:25120
Plus itPlus it
In the present study we exposed WT, p53+/−, Xpa, and Xpa/p53+/− mice to 300 ppm 2-AAF, a bladder and liver carcinogen, to compare the relative contribution of a deficiency in NER, p53, or both on tumor development in two different tumor target tissues. Under the conditions used in this study, WT mice showed no clear tumor response in the liver or the urinary bladder. This finding is in line with previous reports showing that the development of 2-AAF-induced bladder and/or liver tumors takes longer than 39 weeks (40) . In fact, sustained 2-AAF exposure would most likely have resulted in the development of both urinary bladder and liver tumors, because a clear induction of preneoplastic lesions was found in 2-AAF-treated WT mice (Table 1) ⇓ . Interestingly, NER-deficient Xpa mice were clearly susceptible to develop hepatic tumors upon 2-AAF treatment, because a significant increased number of hepatocellular adenomas and carcinomas were found (Table 1) ⇓ . Surprisingly, these mice showed no ...
http://cancerres.aacrjournals.org/content/64/15/5118
Plus itPlus it
A method is described for the isolation of endoplasmic reticulum and Golgi apparatus from hyperplastic liver nodules produced by discontinuous feeding of 2-acetylaminofluorene to male Wistar rats. The procedure involves three centrifugation steps and permits the separation of these cell components and their subfractions from the same sample of liver tissue with as little as 1 g, wet weight. The fractions have been characterized by chemical, enzymatic, and morphological techniques and were found to be as pure as preparations from normal tissue. Furthermore, some of the characteristic histochemical features of hyperplastic liver nodules have been quantitated by biochemical methods in the fractions. Glucose-6-phosphatase activity in the endoplasmic reticulum subfractions of nodules is approximately 15% of the corresponding value in normal livers, whereas the activity of reduced nicotinamide adenine dinucleotide phosphate: cytochrome c reductase is reduced to 85% of the normal activity. The amount ...
http://cancerres.aacrjournals.org/content/43/7/3335
The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis | Science...The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis | Science...
The Hippo-Yap signaling pathway regulates a number of developmental and adult cellular processes, including cell fate determination, tissue growth, and tumorigenesis. Members of the scaffold protein angiomotin (Amot) family interact with several Hippo pathway components, including Yap (Yes-associated protein), and either stimulate or inhibit Yap activity. We used a combination of genetic, biochemical, and transcriptional approaches to assess the functional consequences of the Amot-Yap interaction in mice and in human cells. Mice with a liver-specific Amot knockout exhibited reduced hepatic oval cell proliferation and tumorigenesis in response to toxin-induced injury or when crossed with mice lacking the tumor suppressor Nf2. Biochemical examination of the Amot-Yap interaction revealed that the p130 splicing isoform of Amot (Amot-p130) and Yap interacted in both the cytoplasm and nucleus, which involved binding of PPxY and LPxY motifs in Amot-p130 to WW domains of Yap. In the cytoplasm, ...
https://stke.sciencemag.org/content/6/291/ra77
The Practitioner - 1868-2020: Supporting general practitioners for more than 150 years - GPs should have a high index of...The Practitioner - 1868-2020: Supporting general practitioners for more than 150 years - GPs should have a high index of...
1 Cancer Research UK Testicular cancer statistics www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/testicular-cancer [Last accessed 17 April 2021]. 2 Akre O, Pettersson A, Richiardi L. Risk of contralateral testicular cancer among men with unilaterally undescended testis: a meta analysis. Int J Cancer 2009;124(3):687-89. 3 Lip SZ, Murchison LE, Cullis PS et al. A meta-analysis of the risk of boys with isolated cryptorchidism developing testicular cancer in later life. Arch Dis Child 2013;98(1):20-26. 4 Pettersson A, Richiardi L, Nordenskjold A et al. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med 2007;356(18):1835-41. 5 Hemminki K, Li X. Familial risk in testicular cancer as a clue to a heritable and environmental aetiology. Br J Cancer 2004;90(9):1765-70. 6 Walsh TJ, Croughan MS, Schembri M et al. Increased risk of testicular germ cell cancer among infertile men. Arch Intern Med 2009;169(4):351-56. 7 Manecksha RP, ...
https://www.thepractitioner.co.uk/Symposium/Mens-Health/12454-/GPs-should-have-a-high-index-of-suspicion-for-testicular-cancer
Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced...Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced...
Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) sulfates cholesterol and oxysterols. Hepatic oval cells (HOCs), thought to be progenitor cells, can be triggered in chemically injured livers. The...
https://link.springer.com/article/10.1007%2Fs00204-016-1693-z
Solanum nigrum L. Extract Inhibits 2-Acetylaminofluorene-Induced Hepatocarcinogenesis through Overexpression of Glutathione...Solanum nigrum L. Extract Inhibits 2-Acetylaminofluorene-Induced Hepatocarcinogenesis through Overexpression of Glutathione...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_jf9017788
A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules gen | The Dr. Rath Health FoundationA characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules gen | The Dr. Rath Health Foundation
Biochem Biophys Res Commun 1983 Dec 28;117(3):740-5 Eriksson LC; Sharma RN; Roomi MW; Ho RK; Farber E; Murray RK. The cytosolic polypeptides of hepatocyte nodules in six models of liver carcinogenesis were analysed by SDS-polyacrylamide gel electrophoresis and their patterns compared with these of control and variously treated livers. The amount of a polypeptide of Mr 21,000 was about tenfold elevated in the cytosol of five of the six types of nodules and moderately elevated in the sixth. Certain other polypeptides, particularly one of Mr 26,000, also varied in amount, so that all of the nodules analysed could be distinguished from liver by their electrophoretic patterns. Some possible identities of the two polypeptides are discussed. Their study may have mechanistic as well as diagnostic importance.. ...
http://www4.dr-rath-foundation.org/NHC/studien_team/a_characteristic.htm
Index of /fossils/insects/triassic-insects
Parent Directory - AAF1517A.jpg 19-Jul-2014 17:25 43K AAF1517At.jpg 19-Jul-2014 17:25 5.0K AAF1517B.jpg 19-Jul-2014 17:25 60K AAF1517Bt.jpg 19-Jul-2014 17:25 8.5K AAF1517C.jpg 19-Jul-2014 17:25 73K AAF1517Ct.jpg 19-Jul-2014 17:25 9.6K AAF1517D.jpg 19-Jul-2014 17:25 50K AAF1517Dt.jpg 19-Jul-2014 17:25 6.6K AustralianInsects-L.jpg 19-Jul-2014 17:25 87K AustralianInsects-t.jpg 19-Jul-2014 17:25 5.6K AustralianInsects-th.., 19-Jul-2014 17:25 2.3K Insectfossils37.htm 19-Jul-2014 17:25 4.9K Insectfossils37b.htm 19-Jul-2014 17:25 681 ...
http://www.fossilmuseum.net/fossils/insects/triassic-insects/?C=D
Index of /fossils/hemichordata/Phyllograptus-fructicosus
Parent Directory - AAF78A.jpg 19-Jul-2014 17:16 66K AAF78At.jpg 19-Jul-2014 17:16 5.7K AAF78B.jpg 19-Jul-2014 17:16 63K AAF78Bt.jpg 19-Jul-2014 17:16 6.7K AAF78C.jpg 19-Jul-2014 17:16 66K AAF78Ct.jpg 19-Jul-2014 17:16 6.6K Pendeograpyus-fructi.., 19-Jul-2014 17:16 174K Pendeograpyus-fructi.., 19-Jul-2014 17:16 7.6K Pendeograpyus-fructi.., 19-Jul-2014 17:16 2.6K graptolite.htm 19-Jul-2014 17:16 4.6K graptoliteb.htm 19-Jul-2014 17:16 766 ...
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Plus itPlus it
We have studied the enantioselectivity and regioselectivity of ring-hydroxylation and N-desisopropylation of R(+)- and S(-)-propranolol in microsomes from yeast expressing cytochrome P4502D6 (CYP2D6), using both NADPH and molecular oxygen (NADPH/O2) and cumene hydroperoxide-supported reactions. With NADPH/O2-supported reactions, CYP2D6 catalyzed 4- and 5-ring-hydroxylation, as well as N-desisopropylation of propranolol, although Vmax was considerably greater for ring-hydroxylation, compared with N-desisopropylation. The R/S ratios for KM and Vmax were less than unity for all three pathways. In contrast, using cumene hydroperoxide-supported reactions, CYP2D6 catalyzed 4- and 5-ring-hydroxylation, and there was negligible N-desisopropylation of propranolol. The R/S ratio for KM was less than unity, but the R/S ratio for Vmax was close to unity. The cumyl group of cumene hydroperoxide did not seem to be a selective inhibitor of N-desisopropylation, because i) cumyl alcohol (a nonalkylhydroperoxide ...
http://dmd.aspetjournals.org/content/24/1/112
Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat.Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat.
Further evidence for the preferential interaction of carcinogens with mitochondrial DNA (mtDNA) has been obtained. In rats treated with high doses of N-nitrosodimethylamine (NDMA) or N-nitroso-N-butylurea (NBU), hepatic mtDNA contains 1.4 times more O6-methyl-2-deoxyguanosine (O6-MedG) or 2.3 times more O6-butyl-2-deoxyguanosine (O6-BudG) than does nuclear DNA (nDNA). The kinetics of removal of O6-MeG from mtDNA and nDNA are similar at both high (20 mg/kg) and low (2 mg/kg) doses of NDMA, and the removal of O6-MeG can be increased by pretreating the animals with 2-acetylaminofluorene (AAF), indicating that O6-MeG is repaired in the mitochondrion by a mechanism similar to that which functions in the nucleus. In contrast, O6-BudG is removed very slowly from mtDNA and rapidly from nDNA, an observation which is consistent with the absence of a nucleotide excision mechanism in the mitochondrion and the repair of O6-BudG, predominantly by an excision mechanism, in the nucleus of mammalian cells. A ...
https://christie.openrepository.com/handle/10541/115232
Chemical hepatocarcinogenesis | Biology OpenChemical hepatocarcinogenesis | Biology Open
Guadalupe S. López-Álvarez, Tomasz K. Wojdacz, Claudia M. García-Cuellar, Hugo C. Monroy-Ramírez, Miguel A. Rodríguez-Segura, Ruth A. Pacheco-Rivera, Carlos A. Valencia-Antúnez, Nancy Cervantes-Anaya, Ernesto Soto-Reyes, Verónica R. Vásquez-Garzón, Yesennia Sánchez-Pérez, Saúl Villa-Treviño ...
http://bio.biologists.org/keyword/chemical-hepatocarcinogenesis
The AAF Virtual Debates: Can state-owned banks play an important role in promoting financial stability and access? | All About...The AAF Virtual Debates: Can state-owned banks play an important role in promoting financial stability and access? | All About...
Polling is Closed! The AAF Virtual Debate poll has closed, and the final votes are in. In the final tally, there were 153 yes votes and 51 no votes in response to the question: Can state-owned banks play an important role in promoting financial stability and access? Additional comments on this debate are still welcome. Thanks to everyone who voted or left a comment-we look forward to hosting more debates in the future. If there are particular questions you would like to see debated on the AAF blog, please suggest them in the comments section. ~~~~~~~~~~~~~~~~~~~~~~~~ Introducing the AAF Virtual Debate From February 2-14, the All About Finance blog is hosting a virtual debate on state-owned banks. Asli has invited Professors Franklin Allen and Charles Calomiris to weigh in on the issue. Readers can make their voices heard in the comments section of this post and by voting in a poll here. The results of the poll are displayed below. The AAF Virtual Debate Blog Posts January 31: Aslis Opening Post
http://blogs.worldbank.org/allaboutfinance/comment/98
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Update of /cvsroot/aaf/AAF/ref-impl/src/OM In directory sc8-pr-cvs11.sourceforge.net:/tmp/cvs-serv32104 Modified Files: OMContainerElement.cpp OMKLVStoredObject.cpp OMObjectReference.cpp OMObjectReferenceT.h OMSSStoredObject.cpp OMWeakRefPropertyT.h OMWeakRefSetPropertyT.h OMWeakRefVectorPropertyT.h OMWeakReferenceSetIterT.h OMWeakReferenceVectorIterT.h OMXMLStoredObject.cpp Log Message: In preparation for generalizing weak reference sets and vectors de-templatize the OMWeakObjectReference class by removing template parameter Key. The API changes to specify the key via a void pointer. Index: OMObjectReference.cpp =================================================================== RCS file: /cvsroot/aaf/AAF/ref-impl/src/OM/OMObjectReference.cpp,v retrieving revision 1.20 retrieving revision 1.21 diff -C2 -d -r1.20 -r1.21 *** OMObjectReference.cpp 13 Oct 2006 17:56:43 -0000 1.20 --- OMObjectReference.cpp 23 Feb 2007 22:18:54 -0000 1.21 *************** *** 14,18 **** // under the License. // ! // ...
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Hi Im Prashanth For 3days Im Suffering From Small Oval | Ask The Doctor
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Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis -Nutrition Research and...Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis -Nutrition Research and...
Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis Green tea;hepatocarcinogenesis;initiation;GST-P;rats; The purpose of this study was to investigate the effects of green tea ingestion on hepatocarcinogenesis before and after its initiation. Male Sprague-Dawley rats were fed an AIN76A diet with or without green tea. Initiation was induced by a single dose (200 mg/kg) of diethylnitrosamine at week 4 and 0.02% (w/w) 2-acetylaminofluorene was supplied in the diets. The control group had free access to water for 13 weeks (CTR13). Tea infusion was provided from the beginning of the experiment for 13 weeks (PRE13) or from the post-initiation stage until week 13 (POST13). Three other groups (CTR24, PRE24 and POST24) were added to examine the longer-term effects (24 weeks) with the same experimental design. The percentage area of liver sections that were positive for hepatic placental glutathione S-transferase (GST-P), which was used as a marker of preneoplastic
http://koreascience.or.kr/article/JAKO200806135609503.page
Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene<...Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene<...
TY - JOUR. T1 - Inhibition of mitochondrial oxidative phosphorylation by 2-methyl-4-dimethylaminoazobenzene. AU - Kumar, P. Sai. AU - Kurup, C. K.Ramakrishna. PY - 1984/7/27. Y1 - 1984/7/27. N2 - The azodye 2-methyl-4-dimethylaminoazobenzene inhibited oxidation and phosphorylation in tightly coupled rat liver mitochondria. Phosphorylation was more sensitive to the inhibitory action of the azodye than was the oxidation of succinate or ascorbate. The oxidation of NAD+-linked substrate was severely inhibited by the compound. In submitochondrial particles, only NADH oxidation was sensitive. The site of inhibition has been identified to lie between the dehydrogenase flavoprotein and ubiquinone.. AB - The azodye 2-methyl-4-dimethylaminoazobenzene inhibited oxidation and phosphorylation in tightly coupled rat liver mitochondria. Phosphorylation was more sensitive to the inhibitory action of the azodye than was the oxidation of succinate or ascorbate. The oxidation of NAD+-linked substrate was severely ...
https://scholars.uthscsa.edu/en/publications/inhibition-of-mitochondrial-oxidative-phosphorylation-by-2-methyl
Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac |...Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac |...
Various methods for predicting DDI with enzyme inactivators have been developed, including both static and semiphysiologic models (Galetin et al., 2006; Einolf, 2007; Obach et al., 2007; Grimm et al., 2009; Fenneteau et al., 2010; Quinney et al., 2010), each relying on kdeg for the enzyme as a key input parameter. As physiologically based pharmacokinetic modeling is more routinely applied to predict complex drug interactions, many researchers have noted improved prediction accuracy when using a CYP3A kdeg of 0.03 hour−1(Wang, 2010; Friedman et al., 2011; Yamashita et al., 2013), determined from the time course of CYP3A recovery following multiple-dose clarithromycin administration. The current approach, which resulted in an overall CYP3A kdeg of 0.0240 hour−1, relied on human hepatocytes, specifically the human HepatoPac model, as a viable in vitro surrogate of P450 regulation. Studies from our laboratories and others have characterized the activity, longevity, and functionality of the ...
http://dmd.aspetjournals.org/content/43/9/1307?ijkey=47cc0ffcd945d3f092f988c3332626d4d4d76280&keytype2=tf_ipsecsha
Author: Okuno, M. / Publication Year: 2005 - PubAg Search ResultsAuthor: Okuno, M. / Publication Year: 2005 - PubAg Search Results
We investigated the preventive effects of a synthetic acyclic retinoid, NIK-333, on the early and late events of hepatocarcinogenesis in male F344 rats treated with 3-methyl-4-dimethylaminoazobenzene (3-MeDAB). NIK-333 was administered once a day on consecutive days at a dose of 10, 40, or 80 mg/kg body weight along with the supplementation with 3-MeDAB-containing diet for 16 wk. Animals from e ...
https://pubag.nal.usda.gov/?f%5Bpublication_year_rev%5D%5B%5D=7995-2005&q=%22Okuno%2C+M.%22&search_field=author
CiNii Articles - MORIMOTO Michio
Immunocytochemical and biochemical analysis of the intermediate filaments of the hepatocytes in the chemical carcinogen-induced hyperplastic liver nodules of rats. （1990 ...
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Carcinogen<...Carcinogen<...
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DSpace at EWHA: 백서에서 Cholesterol과 인삼 투여가 Hepatic Cytochrome P-450, b (5) 및 2-AAF의 Hydroxylation에 미치는 영향DSpace at EWHA: 백서에서 Cholesterol과 인삼 투여가 Hepatic Cytochrome P-450, b (5) 및 2-AAF의 Hydroxylation에 미치는 영향
hepatic microsomal mixed function oxidase system의 중추인 cytochrome p-450은 주위환경, 약물, 식이 및 영양 상태에따라 활성이 변화하는것으로 알려져있다. 또한 이 효소계를 통하여 대사되는 2-acetylaminofluorene은 guinea pig를 제외한 모든 동물에서 간암을 일으키는 물질이라는것이 밝혀져서 연구의 대상이 되고있다. 최근 cholesterol은 성인병에 있어 그 원인 인자로서 중요성이 알려지고 있으며 cytochrome p-450과 b_(5)와의 연관성이 보고된바있다. 한편 인삼은 항암작용, 대사촉진, 간조직에서의 해독작용등 여러가지 기능이 보고되어 있다. 이에 저자는 cholesterol을 투여한 흰쥐에서 hepatic microsomal cytochrome p-450 및 b_(5)의 활성에대한 영향과 2-AAF의 ring-hydroxylation과 N-hydroxylation의 변화를 관찰하고, cholesterol과 인삼을 통시에 투여한 군과 비교관찰하여 다음과 같은 결론을 얻었다. 1) 정상 ...
http://dspace.ewha.ac.kr/handle/2015.oak/206686
Most recent papers with the keyword 3d print | Read by QxMDMost recent papers with the keyword 3d print | Read by QxMD
Hepatic oval cells (HOCs) are considered the progeny of the intrahepatic stem cells that are found in a small population in the liver after hepatocyte proliferation is inhibited. Due to their small number, isolation and capture of these cells constitute a challenging task for immunosensor technology. This work describes the development of a 3D-printed continuous flow system and exploits disposable screen-printed electrodes for the rapid detection of HOCs that over-express the OV6 marker on their membrane. Multiwall carbon nanotube (MWCNT) electrodes have a chitosan film that serves as a scaffold for the immobilization of oval cell marker antibodies (anti-OV6-Ab), which enhance the sensitivity of the biomarker and makes the designed sensor specific for oval cells ...
https://www.readbyqxmd.com/keyword/41634
EMF-Portal | The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a...EMF-Portal | The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a...
Animals were given a single injection of diethylnitrosamine two weeks before exposure to initiate hepatocarcinogenesis. Animals for sham exposure were treated the same way as animals in the exposure group but without EMF. Animals in the control group were not placed in the cylinders or exposure boxes ...
https://www.emf-portal.org/de/article/1446
Mouse Oval Cell Marker - NBP1-18961SS | acris-antibodies.com
Mouse Oval Cell Marker, 25 µl. Facultative liver stem cell activation was originally described in the rat, where chemical damage and partial hepatectomy caused the emergence of a new cell type, the oval cell.
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Mouse Oval Cell Marker - NBP1-18961G | acris-antibodies.com
Mouse Oval Cell Marker, 0.1 ml. Facultative liver stem cell activation was originally described in the rat, where chemical damage and partial hepatectomy caused the emergence of a new cell type, the oval cell.
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Evidence for similar principal target proteins of chemical carcinogens by S Sorof and M S. DickensEvidence for similar principal target proteins of chemical carcinogens by S Sorof and M S. Dickens
Sorof, S and Dickens, M S., Evidence for similar principal target proteins of chemical carcinogens in six carcinogen-organ systems. Abstr. (1978). Subject Strain Bibliography 1978. 443 ...
https://mouseion.jax.org/ssbb1978/443/
Carcinogen | pathology | Britannica.comCarcinogen | pathology | Britannica.com
Carcinogen: Carcinogen, any of a number of agents that can cause cancer in humans. They can be divided into three major categories: chemical carcinogens (including those from biological sources), physical carcinogens, and oncogenic (cancer-causing) viruses. Most carcinogens, singly or in combination, produce
https://www.britannica.com/science/carcinogen
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NextPart_01D2C1B6.B22D0830 Content-Location: file:///C:/1EF26892/11.Dr.NikhilChallawar_files/image001.jpg Content-Transfer-Encoding: base64 Content-Type: image/jpeg /9j/4AAQSkZJRgABAQEA3ADcAAD/2wBDAAIBAQIBAQICAgICAgICAwUDAwMDAwYEBAMFBwYHBwcG BwcICQsJCAgKCAcHCg0KCgsMDAwMBwkODw0MDgsMDAz/2wBDAQICAgMDAwYDAwYMCAcIDAwMDAwM DAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAwMDAz/wAARCAEBAOsDASIA AhEBAxEB/8QAHwAAAQUBAQEBAQEAAAAAAAAAAAECAwQFBgcICQoL/8QAtRAAAgEDAwIEAwUFBAQA AAF9AQIDAAQRBRIhMUEGE1FhByJxFDKBkaEII0KxwRVS0fAkM2JyggkKFhcYGRolJicoKSo0NTY3 ODk6Q0RFRkdISUpTVFVWV1hZWmNkZWZnaGlqc3R1dnd4eXqDhIWGh4iJipKTlJWWl5iZmqKjpKWm p6ipqrKztLW2t7i5usLDxMXGx8jJytLT1NXW19jZ2uHi4+Tl5ufo6erx8vP09fb3+Pn6/8QAHwEA AwEBAQEBAQEBAQAAAAAAAAECAwQFBgcICQoL/8QAtREAAgECBAQDBAcFBAQAAQJ3AAECAxEEBSEx BhJBUQdhcRMiMoEIFEKRobHBCSMzUvAVYnLRChYkNOEl8RcYGRomJygpKjU2Nzg5OkNERUZHSElK U1RVVldYWVpjZGVmZ2hpanN0dXZ3eHl6goOEhYaHiImKkpOUlZaXmJmaoqOkpaanqKmqsrO0tba3 ...
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Determining if Something Is a CarcinogenDetermining if Something Is a Carcinogen
Substances and exposures that can lead to cancer are called carcinogens. Learn how possible cancer causes are studied and classified by experts.
https://www.cancer.org/cancer/cancer-causes/general-info/determining-if-something-is-a-carcinogen.html
Ames testAmes test
Examples include tris(2,3-dibromopropyl)phosphate, which was used as a flame retardant in plastic and textiles such as ... ISBN 978-0-7099-1044-2. Hakura A, Suzuki S, Satoh T (January 1999). "Advantage of the use of human liver S9 in the Ames test". ... 455 (1-2): 29-60. doi:10.1016/S0027-5107(00)00064-6. PMID 11113466. Charnley G (2002). "Ames Test". Encyclopedia of Public ... 46 (1-2): 41-4. doi:10.1007/BF00361244. PMID 7235997. S2CID 23769437. Phillipson, Caroline E.; Ioannides, Costas (1989-03-01 ...
https://en.wikipedia.org/wiki/Ames_test
SULT1C2SULT1C2
129 (1-2): 141-70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739. Glatt H, Boeing H, Engelke CE, Ma L, Kuhlow A, Pabel U, ... 482 (1-2): 27-40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246. Kiehlbauch CC, Lam YF, Ringer DP (August 1995). " ... 65 (2): 157-65. doi:10.1006/geno.2000.6150. PMID 10783263. "Entrez Gene: SULT1C1 sulfotransferase family, cytosolic, 1C, member ... v t e (Genes on human chromosome 2, CS1: long volume value, All stub articles, Human chromosome 2 gene stubs). ...
https://en.wikipedia.org/wiki/SULT1C2
AcetoxyacetylaminofluoreneAcetoxyacetylaminofluorene
... is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis. ...
https://en.wikipedia.org/wiki/Acetoxyacetylaminofluorene
HydroxyacetylaminofluoreneHydroxyacetylaminofluorene
... is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis. ...
https://en.wikipedia.org/wiki/Hydroxyacetylaminofluorene
Emmanuel FarberEmmanuel Farber
3.0.CO;2-1. PMID 3167785. S2CID 35730301. 1988 Gelderblom, W.C.A.; Semple, E.; Marasas, W.F.O.; Farber, E. (1992). "The cancer- ... 605 (2): 149-166. doi:10.1016/0304-419X(80)90002-5. PMID 6994812. Solt, D. B.; Cayama, E.; Tsuda, H.; Enomoto, K.; Lee, G.; ... 2. Marcel Dekker. ISBN 0824768388. Faber, E.; Fisher, Murray M., eds. (1980). Toxic Injury of the Liver (Part B). Liver: Normal ... 2. Marcel Dekker. ISBN 0824768396. "Emmanuel Farber, MD, PhD, deceased (1918-2014), Fellow of the Academy of the AACR, Class of ...
https://en.wikipedia.org/wiki/Emmanuel_Farber
HadacidinHadacidin
Glycine, formate, and the 2-carbon of serine were all found to be very quickly incorporated into hadacidin during its synthesis ... 1960), who found that N-hydroxy-2-acetylaminofluorene was formed in the intact rat upon administration of 2-acetylaminofluorene ... and the 2-carbon of glycine were incorporated into both the glycyl and formyl portions of the hydroxamate. N-Hydroxyglycine was ...
https://en.wikipedia.org/wiki/Hadacidin
SULT1C4SULT1C4
129 (1-2): 141-70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739. Glatt H, Boeing H, Engelke CE, et al. (2001). "Human ... 482 (1-2): 27-40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ... 65 (2): 157-65. doi:10.1006/geno.2000.6150. PMID 10783263. Sakakibara Y, Yanagisawa K, Katafuchi J, Ringer DP, Takami Y, ... v t e (Genes on human chromosome 2, CS1: long volume value, All stub articles, Human chromosome 2 gene stubs). ...
https://en.wikipedia.org/wiki/SULT1C4
2-Aminofluorene2-Aminofluorene
... (2-AF) is a synthetic arylamine. It is a white to tan solid with a melting point of 125-132 °C. 2-AF has only ... In molecular biology, 2-AF is able to induce frameshift mutations, by deleting 2 bases in the DNA. DNA is able to undergo a ... In other species, 2-AF was also the cause of mutations in the host genome. The leukocytes, in particular, were able to uptake ... 2-Acetylaminofluorene is able to cause tumors in mice and other animals in the liver and kidney. This substance can act as a ...
https://en.wikipedia.org/wiki/2-Aminofluorene
N-hydroxy-2-acetamidofluorene reductaseN-hydroxy-2-acetamidofluorene reductase
The systematic name of this enzyme class is 2-acetamidofluorene:NAD(P)+ oxidoreductase. Other names in common use include N- ... In enzymology, a N-hydroxy-2-acetamidofluorene reductase (EC 1.7.1.12) is an enzyme that catalyzes the chemical reaction 2- ... Gutmann HR, Erickson RR (1969). "The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver ... Kitamura S, Tatsumi K (1985). "Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol". Biochem. ...
https://en.wikipedia.org/wiki/N-hydroxy-2-acetamidofluorene_reductase
Antineoplastic resistanceAntineoplastic resistance
3.0.co;2-s. ISSN 0020-7136. PMID 10225454. Youn, Cha-Kyung; Kim, Mi-Hwa; Cho, Hyun-Ju; et al. (2004-07-15). "Oncogenic H-Ras Up ... 320 (2): 493-500. doi:10.1016/j.bbrc.2004.06.003. PMID 15219856. Miyashita, T; Reed, JC (January 1, 1993). "Bcl-2 oncoprotein ... 14 (2): 158-168. doi:10.3109/07357909609018891. ISSN 0735-7907. PMID 8597901. Conze, D.; Weiss, L.; Regen, P. S.; et al. (2001- ... Other genes involved in the apoptotic pathway related drug resistance include h-ras and bcl-2/bax. Oncogenic h-ras has been ...
https://en.wikipedia.org/wiki/Antineoplastic_resistance
MutagenMutagen
2-Acetylaminofluorene, originally used as a pesticide but may also be found in cooked meat, may cause cancer of the bladder, ... 3.0.CO;2-#. PMID 11013390. "Calabrese says mistake led to adopting the LNT model in toxicology". phys.org. 2017. Archived from ... Retrieved 2 Jul 2010. Callaway, E (2008). "Skin-tone gene could predict cancer risk". New Scientist. Archived from the original ... August 2005). "Cyclooxygenase-2-mediated DNA damage". The Journal of Biological Chemistry. 280 (31): 28337-46. doi:10.1074/jbc. ...
https://en.wikipedia.org/wiki/Mutagen
Aromatic-hydroxylamine O-acetyltransferaseAromatic-hydroxylamine O-acetyltransferase
... and N-hydroxy-2-acetylaminofluorene N-O acyltransferase. Bartsch H, Dworkin C, Miller EC, Miller JA (1973). "Formation of ...
https://en.wikipedia.org/wiki/Aromatic-hydroxylamine_O-acetyltransferase
List of MeSH codes (D02)List of MeSH codes (D02)
... vitamin k 2 MeSH D02.455.849.291.523.500.922 - vitamin k 3 MeSH D02.455.849.291.850 - taxoids MeSH D02.455.849.291.850.777 - ... 5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 - fanft MeSH D02.640.600.308 - furagin MeSH D02.640.600.313 - ... 2-ethyl 2-(4-nitrophenyl) ester MeSH D02.705.539.783 - phorate MeSH D02.705.539.790 - phosmet MeSH D02.705.539.900 - temefos ... 2-ethyl 2-(4-nitrophenyl) ester MeSH D02.886.309.783 - phorate MeSH D02.886.309.790 - phosmet MeSH D02.886.309.900 - temefos ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
AAFAAF
... a filter used to restrict the bandwidth of a signal 2-Acetylaminofluorene, a biochemical tool Alien Ant Farm, an alternative ...
https://en.wikipedia.org/wiki/AAF
List of MeSH codes (D04)List of MeSH codes (D04)
... vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1-naphthylamine MeSH D04.615.638.845.800 - ... 25-hydroxyvitamin d 2 MeSH D04.808.247.808.489 - fusidic acid MeSH D04.808.247.808.607 - lanosterol MeSH D04.808.247.808.756 - ... 8-hydroxy-2-(di-n-propylamino)tetralin MeSH D04.615.638.960.492 - levobunolol MeSH D04.615.638.960.585 - mibefradil MeSH ... 25-hydroxyvitamin d 2 MeSH D04.808.247.222.537 - ergosterol MeSH D04.808.247.222.857 - sitosterols MeSH D04.808.247.808 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)
2-Acetylaminofluorene2-Acetylaminofluorene
2-AAF is a substrate for cytochrome P-450 (CYP) enzyme, which is a part of a super family found in almost all organisms. This ... 2-Acetylaminofluorene (AAF, 2-AAF) is a carcinogenic and mutagenic derivative of fluorene. It is used as a biochemical tool in ... The interconversion of amide and amine metabolites of 2-AAF can further occur via the microsomal enzyme deacetylase producing ... The reactive nitrenium, carbonium and arylamidonium ion metabolites of 2-AAF react with the nucleophilic groups in DNA, ...
https://en.wikipedia.org/wiki/2-Acetylaminofluorene
Ati - WikipédiaAti - Wikipédia
"Coffee and type 2 diabetes: from beans to beta-cells". Department of Nutrition, Harvard School of Public Health; van Dam RM. ... 2. Role of growth factors and cytokines in hepatic regeneration". Department of Pathology and Laboratory Medicine, Brown ... "Coffee consumption and risk for type 2 diabetes mellitus". Harvard School of Public Health, Channing Laboratory, Harvard ... Lobus ati kawangun saka sèl parenkimal lan sèl non-parenkimal.[2] Sèl parenkimal ing ati diarani hepatosit, manggoni watara 80 ...
https://jv.wikipedia.org/wiki/Liver
NIOSHTIC-2 Search Results - Basic ViewNIOSHTIC-2 Search Results - Basic View
Occupational Health Guidelines for Chemical Hazards (81-123) | NIOSH | CDCOccupational Health Guidelines for Chemical Hazards (81-123) | NIOSH | CDC
2-Acetylaminofluorene. 53-96-3. 0007.pdf pdf icon. No Revision. Acetylene tetrabromide. 79-27-6. 0009.pdf pdf icon. 0009-rev. ... 2-Aminopyridine. 504-29-0. 0026.pdf pdf icon. 0026-rev.pdf pdf icon. ... 2-Butoxyethanol. 111-76-2. 0070.pdf pdf icon. 0070-rev.pdf pdf icon. ... Dimethyl-1,2-dibromo-2,2-dichlorethyl phosphate. 300-76-5. 0225.pdf pdf icon. No Revision. ...
https://www.cdc.gov/niosh/docs/81-123/default.html
NIOSHTIC-2 Search Results - Full ViewNIOSHTIC-2 Search Results - Full View
The hazardous substances included in this report were: 2-acetylaminofluorene (53963), acrylonitrile (107131), aldrin (309002), ... di-2-ethylhexyl-phthalate (117817), 4- dimethylaminoazobenzene (60117), 1,1-dimethylhydrazine (57147), ethylene-dichloride ( ... 2-pentanone (107879), phenylhydrazine (100630), beta-propiolactone (57578), tetramethyl-succinonitrile (3333526), toluene- ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=acrylonitrile&f1=*&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=7&RecNo=66&View=f&
NIOSHTIC-2 Search Results - Basic ViewNIOSHTIC-2 Search Results - Basic View
NIOSHTIC-2 Search Results - Basic ViewNIOSHTIC-2 Search Results - Basic View
Occupational Cancer - Carcinogen List | NIOSH | CDCOccupational Cancer - Carcinogen List | NIOSH | CDC
1,2,3-Trichloropropane. U-Z. Uranium, insoluble compounds Uranium, soluble compounds. Vinyl bromide; class, vinyl halides. ... 2,4-Diaminoanisoleo. o-Dianisidine-based dyes. 1,2-Dibromo-3-chloropropane (DBCP). Dichloroacetylene. p-Dichlorobenzene. 3,3′- ... 1,1,2,2-Tetrachloroethane. Tetrachloroethylene. Titanium dioxide. o-Tolidine-based dyes. o-Tolidine. Toluene diisocyanate (TDI) ... 2-Acetylaminofluorene. Acrylamide. Acrylonitrile. Aldrin. 4-Aminodiphenyl. Amitrole. Aniline and homologs. o-Anisidine. Arsenic ...
https://www.cdc.gov/niosh/topics/cancer/npotocca.html
NIOSHTIC-2 Search Results - Full ViewNIOSHTIC-2 Search Results - Full View
... acetylaminofluorene (53963) (AAF) formation by high pressure liquid chromatography. NOHAAF was rapidly metabolized by cytosolic ... At 2 hours, the amount of AAF was 45 percent of the original amount of NOHAAF. Only 25 percent of the initially added NOHGAF ... No further decrease in NOHGAF was observed in up to 2 hours of incubation. The results indicated that NOHGAF inhibited its own ... The cytosolic metabolism of 2-aminofluorene (153786) (AF) derivatives was studied in liver microsomal fractions obtained from ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=suicide&f1=*&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=21&RecNo=204&View=f&
RTECS:AB9450000 - Acetamide, N-fluoren-2-yl- - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSHRTECS:AB9450000 - Acetamide, N-fluoren-2-yl- - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
Acetylaminofluorene. Azetylaminofluoren (German). FAA. N-2-Fluorenylacetamide. N-9H-Fluoren-2-ylacetamide. N-Acetyl-2- ... Acetylamino)fluorene. 2AAF. 2-AAF. 2-Acetamidofluorene. 2-Acetaminofluorene. 2-Acetylamino-fluoren (German). 2- ... Acetylaminofluorene. 2-Acetylaminofluorene (OSHA). 2-FAA. 2-Fluorenylacetamide. AAF. Acetamide, N-9H-fluoren-2-yl- (9CI). ... 2 µmol/L/16H (+enzymatic activation step). EMMUEG 46,126,2005. mutation in microorganisms. /Salmonella typhimurium. 1.1 µmol/L/ ...
https://www.cdc.gov/niosh-rtecs/AB903210.html
NIOSHTIC-2 Search Results - Basic ViewNIOSHTIC-2 Search Results - Basic View
Irreversible inhibition of the cytosolic metabolism of N-hydroxy-2-acetylaminofluorene by its glycolyl analog. ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=suicide&f1=*&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=202&RecNo=202&View=b&
NIOSHTIC-2 Search Results - Full ViewNIOSHTIC-2 Search Results - Full View
The hazardous substances included in this report were: 2-acetylaminofluorene (53963), acrylonitrile (107131), aldrin (309002), ... di-2-ethylhexyl-phthalate (117817), 4- dimethylaminoazobenzene (60117), 1,1-dimethylhydrazine (57147), ethylene-dichloride ( ... 2-pentanone (107879), phenylhydrazine (100630), beta-propiolactone (57578), tetramethyl-succinonitrile (3333526), toluene- ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=hydroquinone&f1=*&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=3&RecNo=30&View=f&
NIOSHTIC-2 Search Results - Full ViewNIOSHTIC-2 Search Results - Full View
The hazardous substances included in this report were: 2-acetylaminofluorene (53963), acrylonitrile (107131), aldrin (309002), ... di-2-ethylhexyl-phthalate (117817), 4- dimethylaminoazobenzene (60117), 1,1-dimethylhydrazine (57147), ethylene-dichloride ( ... 2-pentanone (107879), phenylhydrazine (100630), beta-propiolactone (57578), tetramethyl-succinonitrile (3333526), toluene- ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=Trichloroethylene&f1=*&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=14&RecNo=134&View=f&
IMSEAR at SEARO: Mutagenicity and anti-mutagenicity of selected spices.IMSEAR at SEARO: Mutagenicity and anti-mutagenicity of selected spices.
Asafoetida and turmetic extract were found to inhibit microsomal activation dependent mutagenicity of 2-acetamidofluorene. ...
https://imsear.searo.who.int/handle/123456789/108736?mode=full
Acetylaminofluorene, 2- (2005-110) | NIOSH | CDCAcetylaminofluorene, 2- (2005-110) | NIOSH | CDC
Acetylaminofluorene, 2- Specific Medical Tests or Examinations Published in the Literature for OSHA-Regulated Substances ... Acetylaminofluorene, 2-. CAS No: 53-96-3. NOTE:. (1) Efficacy of Medical Tests has not been evaluated.. (2) NIOSH references ... Acetylaminofluorene, 2-. Editor(s). /Author(s). Specific Medical Test(s) or Examination(s). Reference(s). ...
https://www.cdc.gov/niosh/docs/2005-110/nmed0004.html
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene | CiNii Research
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene ...
https://cir.nii.ac.jp/crid/1370288394106469505
ATSDR-PHA-HC-Isla de Vieques Bombing Range, Vieques, Puerto RicoATSDR-PHA-HC-Isla de Vieques Bombing Range, Vieques, Puerto Rico
Florida Tanks (2). Florida. Public water supply tank owned by PRASA. Puerto Rico DOH. June 1999a. ... Table B-2.. Sampling Summary of Groundwater Wells on Isla de Vieques, Puerto Rico. Name. Location. Use. Sampling Agency. ... Well 2-3. Martineau. Remote well used by the public when water supply is interrupted. United States Environmental Protection ... 4-A-DNT was not measured directly, but was considered by Hoffsommer and Glover (1978) to be present at the same levels as 2-A- ...
https://www.atsdr.cdc.gov/HAC/PHA/reports/isladevieques_10162001pr/appendices.html
Occupational Chemical Database | Occupational Safety and Health AdministrationOccupational Chemical Database | Occupational Safety and Health Administration
2-AMINO-2-METHYLPROPANOL 124-68-5 *A615. AMP; 2-aminodimethylethanol; β -aminoisobutanol; 2-amino-2-methylpropan-1-ol; 2-amino- ... 309-00-2 *0125. 1,2,3,4,10,10-hexachloro-1,4,4a,5,8,8a-hexahydro-endo-1,4-exo-5,8-dimethanonaphthalene; HHDN; octalene; Seedrin ... ortho-aminoanisole; 2-anisidine; o-methoxyaniline [Note: o-anisidine has been used as a basis for many dyes.]; para- ... lasso; acetanilide, 2 - chloro-2,6-diethyl-N-(methoxymethyl); 2-chloro-N-(2,6-diethylphenyl) N-(methoxymethyl) acetamide; ...
https://www.osha.gov/chemicaldatabase
Understanding the ancillary ligand effect on luminescent cyclometalated Ir(III) complex as a reporter for 2-acetylaminofluorene...
N-2-acetylaminofluorene (AAF) generates different mutational outcomes when placed at G1, G2, and G3 of a NarI sequence (- ... Here, we report the synthesis of three cyclometalated [Ir(L)2dppz]+ complexes (L = 2-phenylpyridine (ppy) 1; benzo[h]quinoline ... Understanding the ancillary ligand effect on luminescent cyclometalated Ir(III) complex as a reporter for 2-acetylaminofluorene ... Remarkably, complexes 1 and 2 displayed dominant 3LC transition characteristic of polar environment despite binding to the ...
https://accounts.public.ce.basespace.illumina.com/b/search/article.nb?id=34843001
Environment and Breast Cancer: Science Review | Silent Spring InstituteEnvironment and Breast Cancer: Science Review | Silent Spring Institute
... acetylamino)fluorene. CAS RN 53-95-2. Chemical Summary Exposure and Risk Assessment ...
http://sciencereview.silentspring.org/mamm_detail.cfm?cid=53-95-2
Registration Dossier - ECHARegistration Dossier - ECHA
2-acetylaminofluorene. Untreated negative controls:. yes. Negative solvent / vehicle controls:. yes. Positive controls:. yes. ... 2 (reliable with restrictions). Rationale for reliability incl. deficiencies:. guideline study. Cross-reference. Reason / ... 2 (reliable with restrictions). Rationale for reliability incl. deficiencies:. guideline study. Justification for type of ... Trisodium 5-[[4-chloro-6-(ethylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(2-sulphonatophenyl)azo]naphthalene-2,7- ...
https://www.echa.europa.eu/it/web/guest/registration-dossier/-/registered-dossier/17878/7/7/2
Rule 3745-114-01 - Ohio Administrative Code | Ohio LawsRule 3745-114-01 - Ohio Administrative Code | Ohio Laws
acetylaminofluorene, 2-. 00053-96-3. acetylene tetrabromide. 00079-27-6. acrolein. 00107-02-8. ... toluene-2,4-diisocyanate or 2,6-diisocyanate (or as a mixture). 00584-84-9; 00091-08-7. ...
https://codes.ohio.gov/ohio-administrative-code/rule-3745-114-01
NIOSHTIC-2 Search Results - Full View
The carcinogens involved are: 4,4-methylene-bis(2- chloroaniline) (101144); benzidine (92875); 3,3-dichlorobenzidine (91941); ... 2-acetylaminofluorene (53963); and 4- dimethylaminoazobenzene (60117). Specific topics pertaining to facilities, personnel ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=Bell&f1=AU&Startyear=&terms=3&Adv=1&ct=&B1=Search&Limit=500&Sort=DP+DESC&whichdate=DP&D1=10&EndYear=&PageNo=56&RecNo=554&View=f&
Proposition 65 List of Elabscience ChemicalsProposition 65 List of Elabscience Chemicals
Bis(2-chloro-1-methylethyl)ether, technical grade - Toxicity: cancer. *Bitumens, extracts of steam-refined and air refined - ... 1,4-Dichloro-2-butene - 764-41-0 - Toxicity: cancer. *3,3-Dichloro-4,4-diamino-diphenyl ether - 28434-86-8 - Toxicity: cancer ... 1-Amino-2-methylanthraquinone - 82-28-0 - Toxicity: cancer. *2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole - 712-68-5 - ... Bis(2-chloroethyl)ether - 111-44-4 - Toxicity: cancer. *N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) - 494-03-1 - ...
https://caslab.com/Proposition-65-List/?setCurrencyId=3
Fluoride Action Network | Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and...Fluoride Action Network | Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and...
Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron - a Garcinia kola ... Taurine (2-aminoethane sulfonic acid) is a free intracellular ?-amino acid with antioxidant, anti-inflammatory, and ...
https://fluoridealert.org/studytracker/38072/
PDF] Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated...PDF] Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated...
Single gene detection with a procedure using 2-acetylaminofluorene (AFF)-modified probes, immunoperoxidase cytochemistry and ...
https://www.semanticscholar.org/paper/Sensitive%2C-high-resolution-chromatin-and-chromosome-Lawrence-Villnave/ed7b525a698e1256e841dff8be812df5dbbf6902
Search Whole Repository | CURVESearch Whole Repository | CURVE
... acetylaminofluorene-induced deletion mutations.. ... Detection and characterization of spontaneous and N-2- ...
https://curve.carleton.ca/search?f%5B0%5D=thesis_degree_level%3AMaster%27s&f%5B1%5D=dcterms_date%3A1998&f%5B2%5D=thesis_degree_discipline%3ABiology
Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver | Journal of Pharmacology and Experimental...Influence of Omeprazole on Multidrug Resistance Protein 3 Expression in Human Liver | Journal of Pharmacology and Experimental...
2). No MRP3 protein was detectable in two livers (with log MRP3 mRNA/β-actin being −5.7 and −5.2; see Fig. 1). In the remainder ... 2. We observed the previously described pattern of two bands, a possible result of different levels of glycosylation (König et ... Figure 2 MRP3 protein expression in human livers. A representative Western blot shows variable MRP3 expression in seven nucleus ... 2000) Characterization of the 5′-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in ...
https://jpet.aspetjournals.org/content/304/2/524?ijkey=3edcab1c5ed0bf98434a781597298e8856cfdc6e&keytype2=tf_ipsecsha
Words with A C D E F N O T U
2 28-letter words with a c d e f n o t u:. * deoxynucleotidyltransferases ... The anion SiPh,sub,3,/sub,F,sub,2,/sub,-; its tetrabutylammonium salt is used in organic synt.... ... A bromochlorodifluoromethane is a haloalkane with the chemical formula CF,sub,2,/sub,ClBr, used in fire extinguishers. ... A hydroxyacetylaminofluorene is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis ...
https://joueb.com/a+c+d+e+f+n+o+t+u/3
Reactome | Homologues of SULT1A1 [cytosol]Reactome | Homologues of SULT1A1 [cytosol]
N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Danio rerio) * SULTs active on NH2AAF [cytosol ...
http://www.reactome.org/content/detail/R-DRE-158474-9
Toonmate Premium Lean-Back Lounge Seat, Right Side | OvertonsToonmate Premium Lean-Back Lounge Seat, Right Side | Overton's
WARNING: This product can expose you to chemicals including Acetaldehyde / 2-Acetylaminofluorene, Bracken fern, which is [are] ...
https://www.overtons.com/toonmate-premium-lean-back-lounge-seat-right-side-300238.html
Find Research outputs - Taipei Medical University
... acetylaminofluorene: A Direct‐acting Carcinogen Inducing Hepatocellular Carcinoma in Sprague‐Dawley Rats. Ho, YS. S. & Lin, JK ... Chen, H. M., Chen, R. J., Fang, J. F. & Wang, C. C., 1994, In: Chang Gung Medical Journal. 17, 2, p. 163-167 5 p.. Research ... Wang, L. M., Yang, H. C., Hwang, J. H., Mou, C. Y. & Horng, H. E., Feb 2 1994, In: Physica B: Condensed Matter. 194-196, PART 2 ... Chen, H. I., Kang, B. H., Wang, J. Y. & Tseng, Y. L., May 23 1994, In: Neuroscience Letters. 173, 1-2, p. 181-184 4 p.. ...
https://tmu.pure.elsevier.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2016&publicationYear=2017&publicationYear=2018&format=&nofollow=true&ordering=publicationYearThenTitle&descending=true&page=858
MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012MESH TREE NUMBER CHANGES - 2013 MeSH. August 27, 2012
D2.705.400.140.175 2,4,5-Trichlorophenoxyacetic Acid D2.241.511.316.881 D2.241.81.18.386.682.800 D2.241.511.316.682.800 2,4- ... 2-Ethyl 2-(4-Nitrophenyl) Ester D2.705.539.750 D2.705.429.812.750 D2.886.309.750 D2.705.539.692.750 D2.886.300.846.750 ... D2.241.81.18.110.80 2-Hydroxy-5-nitrobenzyl Bromide D2.755.566.400 D2.455.426.559.389.657.566.400 2-Methyl-4- ... Replaced for 2012 by Sialic Acid Binding Ig-like Lectin 2) Antigua and Barbuda Z1.639.880.50 Argininosuccinic Acid D2.241. ...
https://decs.bvs.br/P/mnchg2013.txt
Evidence for the lack of hepatic n-acetyltransferase in suncus (Suncus murinus)<...
When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ... When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ... When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ... When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not ...
https://okayama.pure.elsevier.com/en/publications/evidence-for-the-lack-of-hepatic-n-acetyltransferase-in-suncus-su
Faculty of Pharmacy - Research output - Keio University
Oda, S., Sugai, T. & Ohta, H., 2001, In: Chemistry Letters. 6, p. 500-501 2 p.. Research output: Contribution to journal › ... Mashino, T., Okuda, K., Hirota, T., Hirobe, M., Nagano, T. & Mochizuki, M., 2001, In: Fullerene Science and Technology. 9, 2, p ... Satoh, M., Mashino, T., Nagano, T., Hirobe, M., Takayanagi, I. & Koike, K., 2001, In: Fullerene Science and Technology. 9, 2, p ... Oda, S., Sugai, T. & Ohta, H., 2001 Jan 1, In: Journal of Bioscience and Bioengineering. 91, 2, p. 202-207 6 p.. Research ...
https://keio.pure.elsevier.com/en/organisations/1b00-faculty-of-pharmacy/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=publicationYearThenTitle&descending=false&page=12
DeCSDeCS
Acetylaminofluorene. Aminofluorene AAF. Fluoren 2 ylacetamide. Fluoren-2-ylacetamide. N 2 Fluorenylacetamide. N Acetyl 2 ... 2-Acetylaminofluorene - Preferred Concept UI. M0023186. Scope note. A hepatic carcinogen whose mechanism of activation involves ... 83; was ACETYLAMINOFLUORENE 1980-82; was ACETYLAMINOFLUORENE see under FLUORENES 1975-79. ... 83; was ACETYLAMINOFLUORENE 1980-82; was ACETYLAMINOFLUORENE see under FLUORENES 1975-79. ...
https://decs.bvsalud.org/en/ths/resource/?id=115
OBITUARIES 2014 | NIH Intramural Research ProgramOBITUARIES 2014 | NIH Intramural Research Program
Robert E. Cooke (died on February 2, 2014, at 93), a pediatrician, was a member of President John F. Kennedys presidential ... James Bahre (died on October 2, 2014, at 73) provided scientific instruments for NIH medical researchers, working first for ... contributing pioneering work on the mechanism of the carcinogen 2-acetylaminofluorene. He established a research program in ...
https://irp.nih.gov/catalyst/23/1/obituaries-2014
Find Research outputs - NYU Scholars
LeDoux, J. E., Iwata, J., Pearl, D. & Reis, D. J., Apr 23 1986, In: Brain Research. 371, 2, p. 395-399 5 p.. Research output: ... Wellman, P. J., Arasteh, K., Ruddle, J. L. & Strickland, M. D., Jul 1986, In: Brain Research Bulletin. 17, 1, p. 127-128 2 p.. ... Uleman, J. S. & Weston, M., Jul 1986, In: Sex Roles. 15, 1-2, p. 43-62 20 p.. Research output: Contribution to journal › ... Hout, M. & Jackson, J. A., Sep 1986, In: European Sociological Review. 2, 2, p. 114-137 24 p.. Research output: Contribution to ...
https://nyuscholars.nyu.edu/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&ordering=publicationYearThenTitle&descending=true&page=2370
IMSEAR at SEARO: Mutagenicity and anti-mutagenicity of selected spices.
Asafoetida and turmetic extract were found to inhibit microsomal activation dependent mutagenicity of 2-acetamidofluorene. ...
https://imsear.searo.who.int/handle/123456789/108736?mode=full
Section 7412 - Hazardous air pollutants, 42 U.S.C. § 7412 | Casetext Search + CitatorSection 7412 - Hazardous air pollutants, 42 U.S.C. § 7412 | Casetext Search + Citator
2) Coke oven production technology study. (A) The Secretary of the Department of Energy and the Administrator shall jointly ... 2) Construction, reconstruction and modifications. (A) After the effective date of a permit program under subchapter V in any ... 2) Failure to promulgate a standard. In the event that the Administrator fails to promulgate a standard for a category or ... 2) Emission standards. (A) If Congress does not act on any recommendation submitted under paragraph (1), the Administrator ...
https://casetext.com/statute/united-states-code/title-42-the-public-health-and-welfare/chapter-85-air-pollution-prevention-and-control/subchapter-i-programs-and-activities/part-a-air-quality-and-emission-limitations/section-7412-hazardous-air-pollutants
Human POSTN/OSF-2 (Periostin) ELISA Kit | G-EC-04031 | Gentaur Elisa KitsHuman POSTN/OSF-2 (Periostin) ELISA Kit | G-EC-04031 | Gentaur Elisa Kits
Human POSTN/OSF-2 (Periostin) ELISA Kit from Gentaur Elisa Kits. Cat Number: G-EC-04031. USA, UK & Europe Distribution. ... QuicKey Pro Human POSTN/OSF-2 (Periostin) ELISA Kit , G-EC-06109 ... Human POSTN/OSF-2 (Periostin) ELISA Kit , G-EC-04031. Rating * ... Storage: An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the ... Target Synonym: OSF2, PDLPOSTN, PN, RP11-412K4.1, Osteoblast Specific Factor 2. Tested Sample Types: Serum, plasma and other ...
https://caslab.com/human-postn-osf-2-periostin-elisa-kit-g-ec-04031/
Selenium supplementation reduced oxidative stress in diethylnitrosamine-induced hepatocellular carcinoma in rats<...
keywords = "2-acetylaminofluorene, Antioxidant, Diethylnitrosamine, Liver cancer, Sodium selenite",. author = "Jamaludin ... 2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group ... 2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group ... 2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group ...
https://squ.pure.elsevier.com/en/publications/selenium-supplementation-reduced-oxidative-stress-in-diethylnitro
DeCS Ingl s
N-Acetoxy-2-acetylaminofluorene .. N-Acetoxy-N-acetyl-2-aminofluorene .. N Acetoxy 2 acetylaminofluorene .. N Acetoxy N acetyl ... D04.615.389.050 2-Acetylaminofluorene .. D04.615.389.050.060 Acetoxyacetylaminofluorene .. D10 Lipids .. D10.251 Fatty Acids . ... D02.065.064.150 2-Acetylaminofluorene .. D02.065.064.150.100 Acetoxyacetylaminofluorene .. D02.065.199 Anilides .. D02.065. ... D02.241.081.018.110.080 2-Acetylaminofluorene .. D02.241.081.018.110.080.070 Acetoxyacetylaminofluorene .. D02.355 Ethers .. ...
http://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSi&lang=p&minsim=0.30&maxrel=10&text=Acetamides
ArylamineRatsMetaboliteMammaryLiverAdductsDerivativeDeletionDetectionCompounds1996EnzymeVitroStrainsMethodsModelAflatoxinsReferencesOppositeCellsHeadings53963AcetaldehydePlatensisSodiumAcidHemolysinSupplPyruvateApoptosisToxicityEvaluationPhosphorylationTissuesComplicationsMethodsChapterExpressionGroupCenterStressJournalActivityTest
Arylamine2
  • Reference: Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. (neb.com)
  • The C8- and N 2-G adducts derived from 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) were placed at the G1 and G3 sites of the NarI sequence, in which the G3 site is an established hot spot for frameshift mutation with the model arylamine derivative 2-acetylaminofluorene but G1 is not. (neb.com)
Rats5
  • The abilities of liver cytosol fractions from the suncus and Sprague-Dawley (SD) rats to N-acetylate aniline, p-aminobenzoic acid, p-aminosalicylic acid and 2-aminofluorene (AF) were compared. (elsevier.com)
  • When AF was given to the suncus, 2-acetylaminofluorene (AAF), a metabolite of AF formed by N-acetyltransferase (NAT), was not detectable in serum, whereas the metabolite was seen clearly in rats. (elsevier.com)
  • This study emphasizes the role of selenium on oxidative stress in experimental rats with N-diethylnitrosamine (DEN) initiated and 2-acetylaminofluorene (2-AAF) promoted multistage hepatocellular carcinogenesis (HCC). (elsevier.com)
  • Rats were divided randomly into six groups: negative control, positive control (DEN+2-AAF), preventive group (pre-SEE 4 weeks+DEN), preventive control (respective control for preventive group), therapeutic group (DEN+post-SSE 12 weeks) and therapeutic control (respective control for therapeutic group). (elsevier.com)
  • Methods Rats were treated with 2-acetylaminofluorene and carbon tetrachloride to establish the models of hepatic oval cells, two-step collagenase perfusion technique and flow cytometry sorting were used to separate and purify oval cells, and cell culture and amplification were performed. (shsmu.edu.cn)
Metabolite1
  • The enzyme preferentially glucuronidated the N-hydroxy metabolite of 2-acetylaminofluorene and was more active towards the 6- and 12-hydroxylated metabolites of benzo[α]pyrene. (edu.au)
Mammary1
  • Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells. (nih.gov)
Liver1
  • Oval cells in cases like this have been thought to be facultative liver organ stem cells with the capacity of differentiating into both hepatocytes and bile duct epithelial cells.1 2 The relevant query of the foundation of oval cells continues to be open up. (conferencedequebec.org)
Adducts3
  • In 1-base incorporation studies, pol eta inserted C and A, pol iota inserted T, and pol kappa inserted G. Steady-state kinetic parameters were measured for these dNTPs opposite the C8- and N 2-IQ adducts at both sites, being most favorable for pol eta. (neb.com)
  • Thus, the pol eta products yielded frame-shifts with the N 2 but not the C8 IQ adducts. (neb.com)
  • The model carcinogen N-2-acetylaminofluorene covalently binds to the C8 position of guanine to form two adducts, the N-(2'-deoxyguanosine-8-yl)-aminofluorene (G-AF) and the N-2-(2'-deoxyguanosine-8-yl)-acetylaminofluorene (G-AAF). (cnrs.fr)
Derivative1
  • A hydroxyacetylaminofluorene is a derivative of 2-acetylaminofluorene used as a biochemical tool in the study of carcinogenesis. (joueb.com)
Deletion2
  • Detection and characterization of spontaneous and N-2- acetylaminofluorene-induced deletion mutations. (carleton.ca)
  • With the G3 N 2-IQ adduct, a -2 deletion occurred at the site of the adduct. (neb.com)
Detection3
  • Single gene detection with a procedure using 2-acetylaminofluorene (AFF)-modified probes, immunoperoxidase cytochemistry and reflection-contrast microscopy is reported. (semanticscholar.org)
  • Then a biotinylated detection antibody specific for Human POSTN/OSF-2 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (caslab.com)
  • Only those wells that contain Human POSTN/OSF-2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. (caslab.com)
Compounds1
  • Based on these results, the RSMN assay is considered sufficiently validated to establish it as a 'tier 2' assay for dermally exposed compounds and was recently accepted into the OECD's test guideline development program. (mattek.com)
19961
  • Since 1996, the inci- and 2 other genetic markers, toxRS having slightly different Not I patterns dence of V . parahaemolyticus infec- and orf8 (1,3). (cdc.gov)
Enzyme1
  • Moreover, retinoids induced CYP3A4 enzyme activity in HepG2 human hepatoma and Caco-2 human colorectal adenocarcinoma cells. (scite.ai)
Vitro1
  • This ELISA kit applies to the in vitro quantitative determination of Human POSTN/OSF-2 concentrations in Serum, plasma and other biological fluids. (caslab.com)
Strains1
  • seafood-associated bacterial gastroen- the virulence-associated hemolysins, With the exception of the strain teritis in the world, often associated thermostable-direct hemolysin, and belonging to the old O3:K6 clone, the with the consumption of raw or under- thermostatable-related hemolysin (2), PFGE-typeable O3:K6 strains, despite cooked seafood. (cdc.gov)
Methods1
  • Even after these methods were developed, and even after various guidelines were developed by various regulatory agencies in the United States, they were often not observed (2, 3, 7, 9, 10). (cdc.gov)
Model1
  • Lucas, P and Horton, BJ, Guidelines for treatment of lice in sheep with long wool based on a model of the development of wool damage , Australian Veterinary Journal, 92, (1-2) pp. 8-14. (edu.au)
Aflatoxins1
  • Giacomini et al, Animal Health, 2, Investigations into the presence of aflatoxins in human body fluids and tissues in relation to child health in the tropics. (kentyapi.info)
References1
  • 2) NIOSH references include diagnostic, screening, and other tests. (cdc.gov)
Opposite1
  • With the G1 N 2-IQ adduct, the product was error-free at the site opposite the base and then stalled. (neb.com)
Cells2
  • UGT1A3, when expressed in COS cells has a relative molecular mass of 55 kDa and is active in the glucuronidation of estrone and 2-hydroxyestrone. (edu.au)
  • Yet in some circumstances where hepatocyte replication can be suppressed such as for example after treatment with 2-acetylaminofluorene (2AAF) oval cells will proliferate and differentiate to replenish the hepatic mass. (conferencedequebec.org)
Headings1
  • Concentrations for 20 substances were listed under the headings: (1) Rapidly fatal to man and animals, (2) Dangerous in 0.51 h, (3) 0.51 h without serious disturbances, and (4) Only minimal symptoms observed (3). (cdc.gov)
539631
  • Mononuclear leukocytes (MNL) metabolized AF to its acetylated form 2-acetylaminofluorene (53963) (AAF). (cdc.gov)
Acetaldehyde1
  • WARNING: This product can expose you to chemicals including Acetaldehyde / 2-Acetylaminofluorene, Bracken fern, which is [are] known to the State of California to cause cancer. (overtons.com)
Platensis2
  • To study the effect of C-Phycocyanin (C-PC), a biliprotein isolated from Spirulina platensis, on 2-acetylaminofluorene (2-AAF) induced oxidative stress and MDR1 expression in the liver of albino mice. (nih.gov)
  • Holman, B and Kashani, A and Malau-Aduli, AEO, Wool quality traits of purebred and crossbred Merino lambs orally drenched with Spirulina ( Arthrospira platensis ) , Italian Journal of Animal Science, 13, (2) pp. 387-391. (edu.au)
Sodium1
  • Solvents used: sterile, redistilled water (for the test substance and sodium azide reference substance solution) and DMSO (for 2-aminoanthracene and 4-nitro-o-phenylendiamine reference solutions). (europa.eu)
Acid1
  • 10. The ink composition of claim 8, wherein at least one of the first or second vinyl chloride-vinyl acetate resins includes from 0.1 wt % to 2 wt % of dicarbonic acid. (freepatentsonline.com)
Hemolysin2
  • seafood-associated bacterial gastroen- the virulence-associated hemolysins, With the exception of the strain teritis in the world, often associated thermostable-direct hemolysin, and belonging to the old O3:K6 clone, the with the consumption of raw or under- thermostatable-related hemolysin (2), PFGE-typeable O3:K6 strains, despite cooked seafood. (cdc.gov)
  • All isolates were characterized by polymerase chain reaction (PCR) to detect the genes encoding the virulence-associated hemolysins, thermostable-direct hemolysin, and thermostatable-related hemolysin ( 2 ), and 2 other genetic markers, toxRS and orf8 ( 1 , 3 ). (cdc.gov)
Suppl1
Pyruvate1
  • An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (uams.edu)
Apoptosis1
  • 2. Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. (nih.gov)
Toxicity1
  • 1,2-Dithiole-3-thione was a less effective inhibitor and exhibited both a systemic toxicity and genotoxicity in alveolar macrophages, whereas its substituted analogue Oltipraz showed limited protective effects in this model. (aacrjournals.org)
Evaluation2
  • Linear regression evaluation was performed to calculate em R /em 2 of DNA quantification dimension methods in comparison to ddPCR outcomes. (bioxorio.com)
  • Open up in another window Amount 2 Evaluation of cfDNA concentrations in matched bloodstream examples in four different BCTs. (bioxorio.com)
Phosphorylation2
  • Co-administration of C-PC and 2-AAF inhibited the expression of MDR1 by preventing ROS generation, Akt phosphorylation and NF-kappaB nuclear translocation. (nih.gov)
  • 2012). On the other hand, the manifestation of interleukin-1 and cyclooxygenase-2 in microglial cells from also advertised the phosphorylation of NF-B-inhibitory subunit p50 at S337 as well as the nuclear build up of NF-B (Russo et al. (bio-aromatica.com)
Tissues1
  • PB treatment of animals with DEN/AAF-induced nodules greatly increased P450 2B1/2 expression in surrounding tissues, whereas most, but not all, nodules were not inducible. (nih.gov)
Complications1
  • Atorsan is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors. (medsonline365.us)
Methods1
  • Even after these methods were developed, and even after various guidelines were developed by various regulatory agencies in the United States, they were often not observed (2, 3, 7, 9, 10). (cdc.gov)
Chapter1
Expression2
  • 2-AAF treatment resulted in upregulation of MDR1 expression and enhanced the generation of reactive oxygen species (ROS). (nih.gov)
  • To examine this hypothesis further, hepatic hyperplastic nodules were produced with AFB (10 ip doses of AFB, 150 micrograms/kg/day, followed by partial hepatectomy) or by a modified Solt-Farber protocol (DEN/AAF), and the effects of PB on nodule growth and expression of cytochrome(s) P450 2B1 and/or P450 2B2 (P450 2B1/2) were determined. (nih.gov)
Group2
  • The first group was treated with the vehicle (absolute alcohol), the second group was treated with C-PC (50 mg/kg body weight), the third group was treated with 2-AAF (25 mg/kg body weight) and the fourth group was treated with C-PC (50 mg/kg body weight) and 2-AAF, daily for 3 days. (nih.gov)
  • 2. The ink composition of claim 1, further comprising at least one additive selected from the group of surfactants, wetting agents, dispersants, leveling agents, and preservatives. (freepatentsonline.com)
Center1
  • This was a headquarter position at level of Senior Director (level Executive Committee +2), reporting to the Vice President, Global Center for Scientific Affairs (scientific body across all therapeutic areas). (ous-research.no)
Stress2
  • 2-AAF-induced oxidative stress is reduced by C-PC treatment. (nih.gov)
  • This study reveals the usefulness of C-PC in preventing oxidative stress and downregulation of MDR1 induced by xenobiotics like 2-AAF. (nih.gov)
Journal1
  • Lucas, P and Horton, BJ, Guidelines for treatment of lice in sheep with long wool based on a model of the development of wool damage , Australian Veterinary Journal, 92, (1-2) pp. 8-14. (edu.au)
Activity1
  • Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). (nih.gov)
Test1
  • SETTING UP THE PLATES: 0.1 ml of test solution at each dose level, solvent control, negative control, or reference mutagen solution (positive control) and 0.5 ml of S9 mix (for test with metabolic activation) or S9 mix substitution-buffer (for test without metabolic activation) and 0.1 ml of bacteria suspension and 2 ml of overlay agar were mixed in a test tube and poured onto the selective agar plates. (europa.eu)