An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.
A group of ribonucleotides (up to 12) in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
The phylum of sponges which are sessile, suspension-feeding, multicellular animals that utilize flagellated cells called choanocytes to circulate water. Most are hermaphroditic. They are probably an early evolutionary side branch that gave rise to no other group of animals. Except for about 150 freshwater species, sponges are marine animals. They are a source of ALKALOIDS; STEROLS; and other complex molecules useful in medicine and biological research.
A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-.
RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Established cell cultures that have the potential to propagate indefinitely.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Proteins prepared by recombinant DNA technology.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
A subclass of enzymes that aminoacylate AMINO ACID-SPECIFIC TRANSFER RNA with their corresponding AMINO ACIDS.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
The rate dynamics in chemical or physical systems.
Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.
Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.
Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
... oligoadenylate synthetase-like 2 is a protein that in the house mouse is encoded by the Oasl2 gene. The gene is also known as ... oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells". Journal of ... oligoadenylate synthetase-like 2". Retrieved 2011-12-11. "Salmonella infection data for Oasl2". Wellcome Trust Sanger Institute ... oligoadenylate synthetase gene family". Molecular Biology and Evolution. 17 (5): 738-750. doi:10.1093/oxfordjournals.molbev. ...
... oligoadenylate synthetase-like protein is an enzyme that in humans is encoded by the OASL gene. 2'-5'-oligoadenylate synthase ... oligoadenylate synthetase-like". Mackay V, Linn S (1976). "Selective inhibition of the dnase activity of the recBC enzyme by ... oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the ... oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1". Eur. J. ...
... oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene. This gene encodes an enzyme included in ... oligoadenylate synthetase". Genomics. 70 (2): 232-40. doi:10.1006/geno.2000.6382. PMID 11112351. Ito M, Shichijo S, Tsuda N, et ... oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and ... oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three ...
... oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene. This gene encodes a member of the 2-5A ... oligoadenylate synthetases". J. Biol. Chem. 274 (36): 25535-42. doi:10.1074/jbc.274.36.25535. PMID 10464285. v t e (Genes on ... oligoadenylate synthetase 1, 40/46kDa". Justesen J, Hartmann R, Kjeldgaard NO (2000). "Gene structure and function of the 2'-5 ... oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein". J. Biol. Chem. 272 (52 ...
... oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene. This gene encodes a member of the 2-5A ... oligoadenylate synthetase 2, 69/71kDa". Justesen J, Hartmann R, Kjeldgaard NO (2000). "Gene structure and function of the 2'-5 ... oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and ... oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C". Liver. 13 (5): 253-8. doi:10.1111/j. ...
Oligoadenylate Synthetase (OAS). The transcribed RNA is then spliced and modified in the nucleus before reaching the cytoplasm ... oligoadenylate synthetases". Methods in Molecular Medicine. Human Press Inc. 116: 81-101. doi:10.1385/1-59259-939-7:081. ISBN ... oligoadenylate synthetase-dependent ribonuclease - is an interferon (IFN)-induced ribonuclease which, upon activation, destroys ... linked oligoadenylates (2-5A), which are 5' end phosphorylated. 2-5 A molecules then bind to RNase L, promoting its activation ...
... oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome". PLOS ONE. 9 (3): e92545. Bibcode: ... oligoadenylate synthase (OAS) component of the innate immune response has been shown to be particularly important in protection ... 83 (2): 77-85. PMC 2892770. PMID 20589188. Langley JM, Aoki F, Ward BJ, McGeer A, Angel JB, Stiver G, et al. (February 2011). " ... On 17 June 2016, the WHO agreed to the use of 1/5 the usual dose as an emergency measure during the ongoing outbreak in Angola ...
... oligoadenylate synthetase activity in the cat". The Journal of Veterinary Medical Science. 55 (1): 1-6. doi:10.1292/jvms.55.1. ... 27 (2): 119-27. doi:10.1089/jir.2006.0094. PMID 17316139. Li SF, Zhao FR, Shao JJ, Xie YL, Chang HY, Zhang YG (November 2017 ... 56 (2): 211-4. doi:10.1271/bbb.56.211. PMID 1377975.; GenBank Accession number: E02521 Ueda Y, Sakurai T, Kasama K, Satoh Y, ... February 1993). "Pharmacokinetic properties of recombinant feline interferon and its stimulatory effect on 2',5'- ...
... oligoadenylate synthetase". Eur. J. Biochem. 257 (2): 319-30. doi:10.1046/j.1432-1327.1998.2570319.x. PMID 9826176. Guo J, Sen ... 267 (2): 209-19. doi:10.1006/viro.1999.0135. PMID 10662616. Guo J, Hui DJ, Merrick WC, Sen GC (2001). "A new pathway of ... 13 (2): 458-60. doi:10.1016/0888-7543(92)90272-T. PMID 1377167. Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI ... 169 (2): 313-21. doi:10.1111/j.1432-1033.1987.tb13614.x. PMID 3121313. Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning ...
... oligoadenylate synthetase family, which degrades viral RNA. Some viruses evade this by producing molecules that interfere with ... 5 (6): 1003-1011. doi:10.1016/S1097-2765(00)80265-8. PMID 10911994. Rojo E, Martín R, Carter C, Zouhar J, Pan S, Plotnikova J, ... 252 (2): 324-330. doi:10.1006/viro.1998.9508. PMID 9878611. Rodriguez-Madoz JR, Belicha-Villanueva A, Bernal-Rubio D, Ashour J ... 11 (5): 32-34. Archived from the original (PDF) on 6 July 2007. Baulcombe D (September 2004). "RNA silencing in plants". Nature ...
... oligoadenylate synthetase, sensitive to the presence of dsRNA longer than 15 base pairs. Because this mechanism is not ... 18 (5-6): 363-371. doi:10.1016/j.cytogfr.2007.06.016. ISSN 1359-6101. PMC 2084215. PMID 17698400. Williams, B. R. (2001-07-03 ... Hassel, B A; Zhou, A; Sotomayor, C; Maran, A; Silverman, R H (August 1993). "A dominant negative mutant of 2-5A-dependent RNase ... Groups have found that the Interferon Signaling promotes the activation of a 2'-5'- ...
... oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III ... 17 (2): 103-6. doi:10.1177/039463200401700201. PMID 15171810. S2CID 43322911. Sheppard P, Kindsvogel W, Xu W, Henderson K, ...
... oligoadenylate synthetase MeSH D08.811.913.696.445.650 - polynucleotide adenylyltransferase MeSH D08.811.913.696.445.692 - rec ... amino acyl-trna synthetases MeSH D08.811.464.263.200.050 - alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ... atp synthetase complexes MeSH D08.811.913.696.650.150.500 - proton-translocating atpases MeSH D08.811.913.696.650.150.500.249 ... fatty acid synthetase complex MeSH D08.811.600.391 - glycine decarboxylase complex MeSH D08.811.600.391.100 - ...
... oligoadenylate synthetase (2-5A synthetase) is an enzyme (EC 2.7.7.84) that reacts to interferon signal. It is an antiviral ... oligoadenylate synthetase, also referred to as domain 2 of the enzyme, is largely alpha-helical and homologous to a tandem ... oligoadenylate synthetase". Mol. Cell. 12 (5): 1173-85. doi:10.1016/S1097-2765(03)00433-7. PMID 14636576. This article ... oligoadenylate synthetases. Structure-function relationships". J. Biol. Chem. 266 (23): 15293-9. PMID 1651324. Hartmann R, ...
... members of the oligoadenylate synthetase family of proteins (OAS1, OAS2, OAS3), and others. All of these proteins can ... 23 (2): 165-175. doi:10.1016/j.immuni.2005.06.008. PMID 16111635. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004 ... 29 (2): 178-181. doi:10.1016/j.immuni.2008.07.009. PMID 18701081. Schmidt A, Schwerd T, Hamm W, Hellmuth JC, Cui S, et al. ( ... 33 (2): 104-12. doi:10.1016/j.ymeth.2003.11.002. PMID 15121164. Hellgren I, Drvota V, Pieper R, Enoksson S, Blomberg P, Islam ...
... synthetase Polyadenylate nucleotidyltransferase Polyadenylate polymerase Polyadenylate synthetase Polyadenylic acid polymerase ... Mans RJ, Walter TJ (1971). "Transfer RNA-primed oligoadenylate synthesis in maize seedlings. II Primer, substrate and metal ... U.S.A. 69 (2): 417-21. doi:10.1073/pnas.69.2.417. PMC 426470. PMID 4501121. Colgan DF, Murthy KG, Prives C, Manley JL (November ... 384 (6606): 282-5. Bibcode:1996Natur.384..282C. doi:10.1038/384282a0. PMID 8918882. S2CID 4304275. Portal: Biology (EC 2.7.7, ...
... oligoadenylate synthase EC 2.7.7.86: cyclic GMP-AMP synthase The remaining entries have no Wikipedia articles EC 2.7.7.87: L- ... glutamine synthetase] adenylyltransferase EC 2.7.7.43: N-acylneuraminate cytidylyltransferase EC 2.7.7.44: glucuronate-1- ... synthase EC 2.7.7.88: GDP polyribonucleotidyltransferase EC 2.7.7.89: [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase ... This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by ...
... oligoadenylate synthetase-ribonuclease L; ORF, open reading frame; PA, polymerase acidic; PB, polymerase basic; PKR, protein ... Zhang AJ, Lee AC, Chan JF, Liu F, Li C, Chen Y, et al. Coinfection by severe acute respiratory syndrome coronavirus 2 and ... Dee K, Goldfarb DM, Haney J, Amat JA, Herder V, Stewart M, et al. Human rhinovirus infection blocks SARS-CoV-2 replication ... 5). Influenza virus. IFN induction: NS1 interferes with viral RNA sensing by TLR and RIG-I, binds to viral RNA and reduces RIG- ...
... oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease ...
Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus ... oligoadenylate synthetase genes: a case-control study. The Brazilian journal of infectious diseases : an official publication ... 5´cap -independent translation of dengue virus genomic RNA]. Revista peruana de medicina experimental y salud pública 0 32 (1 ... Association of dengue virus infection susceptibility with polymorphisms of 2'-5'- ...
... oligoadenylate synthetase activity increases prior to the appearance of neutralizing antibodies and immunoglobulin M and ... BOX 2. CDC's Yellow Fever Vaccine Safety (YFVS) Working Group case definition* for yellow fever vaccine-associated ... 2Division of Global Migration and Quarantine, National Center for Emerging and Zoonotic Infectious Diseases ... FIGURE 2. Areas* at risk for yellow fever transmission --- Africa and South America, 2009 ...
... oligoadenylate synthetase, but this genetic susceptibility has not been elucidated in humans (10). Although most nonfatal WNV ... The virus has 2 genetic lineages: lineage 1 strains are found in North America, Europe, Africa, Asia, and Australia; lineage 2 ... Over the past 5 years, research on WNV disease has expanded rapidly. This review highlights new information regarding the ... Research on the signs, symptoms, and pathogenesis of WNV disease has greatly intensified in the past 5 years. The number of ...
... oligoadenylate synthetase/RNase L, or the MxA protein. dsRNA, ssRNA, and CpG oligonucleotides are ligands for toll-like ... Volume 12, Number 5-May 2006 Letter. Biodefense Shield and Avian Influenza On This Page ... 2006;12(5):873-875. doi:10.3201/eid1205.051480.. APA. Alibek, K., & Liu, G. (2006). Biodefense Shield and Avian Influenza. ... Volume 12, Number 5-May 2006. Article Views: 311. Data is collected weekly and does not include downloads and attachments. View ...
... oligoadenylate synthetase 1 polymorphism is associated with prostate cancer. Cancer 2011 Dec 117 (24): 5509-18. Mandal Sanjay, ... Actas urologicas españolas 2012 May 36 (5): 306-11. Alvarez-Cubero M J, Saiz M, Martínez-González L J, Alvarez J C, Lorente J A ... Prostate cancer and prostatic diseases 2012 Jun 15 (2): 144-9. Alvarez-Cubero M J, Entrala C, Fernandez-Rosado F, Martinez- ... Whole Exome Sequencing in BRCA1-2 Candidate Families: The Contribution of Other Cancer Susceptibility Genes. Frontiers in ...
Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus ... oligoadenylate synthetase genes: a case-control study. The Brazilian journal of infectious diseases : an official publication ... Association of dengue virus infection susceptibility with polymorphisms of 2'-5'- ... 390-5. Alagarasu K, Honap T, Damle I M, Mulay A P, Shah P S, Cecilia ...
... oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. The Journal of infectious ...
... oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. The Journal of infectious ... The Journal of infectious diseases 2010 Jan 201 (2): 178-85. Lim Jean K, McDermott David H, Lisco Andrea, Foster Gregory A, ... PLoS pathogens 2009 Feb 5 (2): e1000321. Lim Jean K, Lisco Andrea, McDermott David H, Huynh Linda, Ward Jerrold M, Johnson ... The Journal of infectious diseases 2008 Jan 197 (2): 262-5. Lim Jean K, Louie Christine Y, Glaser Carol, Jean Cynthia, Johnson ...
Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus ... oligoadenylate synthetase genes: a case-control study. The Brazilian journal of infectious diseases : an official publication ... Association of dengue virus infection susceptibility with polymorphisms of 2'-5'- ... 390-5. Alagarasu K, Honap T, Damle I M, Mulay A P, Shah P S, Cecilia ...
Oligoadenylate Synthetase-Like Protein. Justin D Shepard, Brendan T Freitas, Sergio E Rodriguez, Florine E M Scholte, Kailee ... The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' ...
... oligoadenylate synthetase-like. 3.46. FIT1. Interferon-induced protein with tetratricopeptide repeats 1. 10.74. ...
Oligoadenylate Synthetase 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. ... Oligoadenylate Synthetase 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. ... Oligoadenylate Synthetase 1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. ... Oligoadenylate Synthetase 1 (OAS1) in samples from serum, plasma and other biological fluids with no significant corss- ...
... oligoadenylate synthetase-like 2 is a protein that in the house mouse is encoded by the Oasl2 gene. The gene is also known as ... oligoadenylate synthetase with a ubiquitin-like extension, is induced during maturation of murine dendritic cells". Journal of ... oligoadenylate synthetase-like 2". Retrieved 2011-12-11. "Salmonella infection data for Oasl2". Wellcome Trust Sanger Institute ... oligoadenylate synthetase gene family". Molecular Biology and Evolution. 17 (5): 738-750. doi:10.1093/oxfordjournals.molbev. ...
... oligoadenylate synthetase and increase resistance to cleavage by RNase L. Nucleic Acids Res. 39, 9329-9338 (2011). ... oligoadenylate synthetase (OAS), leading to the inhibition of translation38 and the degradation of cellular mRNA and ribosomal ... Figure 2: Major delivery methods for mRNA vaccines.. Commonly used delivery methods and carrier molecules for mRNA vaccines ... Table 2 Clinical trials with mRNA vaccines against infectious diseases. Full size table. ...
Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity. *Jan Lohöfener, ... oligoadenylate synthetase (OAS), a highly conserved component of innate antiviral immunity. Their results indicate a sequential ... High-affinity drug binding and high-potency enzyme activity inhibition confirms prolyl-tRNA synthetases as valuable new anti- ... Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and ...
... oligoadenylate synthetase activity increases prior to the appearance of neutralizing antibodies and immunoglobulin M and ... BOX 2. CDCs Yellow Fever Vaccine Safety (YFVS) Working Group case definition* for yellow fever vaccine-associated ... 2Division of Global Migration and Quarantine, National Center for Emerging and Zoonotic Infectious Diseases ... FIGURE 2. Areas* at risk for yellow fever transmission --- Africa and South America, 2009 ...
... oligoadenylate synthetase is insensitive to dsRNA and interferon stimulation in autoimmune BB rats. Bonnevie-Nielsen, V., Husum ... oligoadenylate synthetase is insensitive to dsRNA and interferon stimulation in autoimmune BB rats. Bonnevie-Nielsen, V., Husum ... Hansen, T., Andreasen, P., Dreisig, H., Højrup, P., Nielsen, H., Engberg, J. & Kristiansen, Karsten, 1991, In: Gene. 105, 2, p ... Hansen, H. O., Andreasen, P. H., Mandrup, S., Kristiansen, Karsten & Knudsen, J., 1991, In: Biochemical Journal. 277 ( Pt 2), p ...
... oligoadenylate synthetase-like protein, OASL [117808] (1 species). *. Species Human (Homo sapiens) [TaxId:9606] [117809] (1 PDB ... Species Human (Homo sapiens) [TaxId:9606] [142947] (2 PDB entries). Uniprot Q9H347 11-104! Uniprot Q9H347 15-98. ... Species Mouse (Mus musculus) [TaxId:10090] [89833] (2 PDB entries). *. Ubiquitin-like domain of Rad23 homolog A (Hhr23a) [ ... Ubiquitin-like N-terminal domain of PLIC-2 [75358] (1 species). *. Species Human (Homo sapiens) [TaxId:9606] [75359] (1 PDB ...
Oligo-Adenylate Synthetase and RNase-L: Key Enzymes in the Antiviral Defense Mechanism. Herst CV ... Sandman CA, Moore S. CFIDS923 IGER , The MMPI-2 CFS Profile. Iger LM. CFIDS923 HERST , 2-5 ... 2 USA, $3 Canada; make check payable to Hunter House Inc., 2200 Central Ave., Alameda, CA 94501-4451, USA; or use VISA or M/C; ...
... oligoadenylate synthetase 1H. Oas1g. 5. 120876142 to 120887613 11471. -. protein coding gene. 2-5 oligoadenylate synthetase ... oligoadenylate synthetase 1F. D5Mit368. 5. 120860323 to 120860424 101. DNA segment. DNA Segment, Chr 5, Massachusetts Institute ... 2-5 oligoadenylate synthetase 1A. Tssr52995. 5. 120898191 to 120898209 18. -. TSS region. transcription start site region ... Click here to work with the entire chromosomal region 5:120856142-120907613 .tablesorter thead .disabled { display:none; } ...
... oligoadenylate synthetase 1H. MGI feature type. protein coding gene. MGI marker type. Gene. ...
... oligoadenylate synthetase-like. 3.46. FIT1. Interferon-induced protein with tetratricopeptide repeats 1. 10.74. ...
2) CT group (basal diet + 40 mg/kg colistin); 3) LL group (basal diet + 1 × 107 CFU/pig/day LB1); 4) HL group (basal diet + 1 ... 2) CT group (basal diet + 40 mg/kg colistin); 3) LL group (basal diet + 1 × 107 CFU/pig/day LB1); 4) HL group (basal diet + 1 ... 108 CFU/pig/day LB1); 5) ETEC group: (basal diet + ETEC challenged); 6) CT + ETEC group (basal diet + CT + ETEC); 7) LL + ETEC ... 108 CFU/pig/day LB1); 5) ETEC group: (basal diet + ETEC challenged); 6) CT + ETEC group (basal diet + CT + ETEC); 7) LL + ETEC ...
... oligoadenylate synthetase and enzymatic synthesis of oligomers. 1983. Hughes, B.; Srivastava, P.; Muse, D.; Robins, R. ... Oligoadenylates and related 2,5-oligonucleotide analogues. 1. Substrate specificity of the interferon-induced murine 2,5- ... IC50 Value (5 results). top print hide Please wait a moment until the data is sorted. This message will disappear when the data ... Product in Enzyme-catalyzed Reactions (2 results). top print hide Please wait a moment until the data is sorted. This message ...
... oligoadenylate synthetase 1 polymorphism is associated with prostate cancer. Cancer 2011 Dec 117 (24): 5509-18. Mandal Sanjay, ... Actas urologicas españolas 2012 May 36 (5): 306-11. Alvarez-Cubero M J, Saiz M, Martínez-González L J, Alvarez J C, Lorente J A ... Prostate cancer and prostatic diseases 2012 Jun 15 (2): 144-9. Alvarez-Cubero M J, Entrala C, Fernandez-Rosado F, Martinez- ... Whole Exome Sequencing in BRCA1-2 Candidate Families: The Contribution of Other Cancer Susceptibility Genes. Frontiers in ...
... oligoadenylate synthetase 1b. Virology. 2010;399:176-185. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 23] [ ... oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice. Proc Natl Acad Sci ... oligoadenylate synthetase 1b protein[77], and also to resistance against the flavivirus inhibitor lycorine thanks to the ... 2009;5:e1000672. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 62] [Cited by in F6Publishing: 64] [Article ...
... oligoadenylate synthetase gene expression by mild hyperthermia (39.5 degrees C) in cultured human cells. J Biol Chem 1991;266: ... 5 Kunutsor SK, Laukkanen T, Laukkanen JA. Frequent sauna bathing may reduce the risk of pneumonia in middle-aged Caucasian men ... Clin Infect Dis 2004;39:1531-5.. 19 Gryka D, Pilch WB, Czerwinska-Ledwig OM, et al. The influence of Finnish sauna treatments ... Forschende Komplementarmedizin (2006) 2015;22:320-5.. 4 Ernst E, Pecho E, Wirz P, et al. Regular sauna bathing and the ...
... oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection The Journal of infectious ... Yakub I, Lillibridge KM, Moran A, Gonzalez OY, Belmont J, Gibbs RA, Tweardy DJ, Single nucleotide polymorphisms in genes for 2 ...
... oligoadenylate synthetase (OAS) family members OAS1, OAS2, OAS3, and OASL. CBD also augmented expression of these genes in ... 2. Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 ... SARS-CoV-2 uses receptor-mediated entry into a human host via the angiotensin-converting enzyme 2 (ACE2), which is expressed in ... The SARS-CoV-2 has been recognized as the responsible pathogen for COVID-19 with high infection and mortality rate potential. ...
2.. Vortex working bead suspension for 15 seconds.. 3.. Add 45 µL of capture bead working suspension to each well. NOTE: Save ... 5.. Remove buffer in the wells by using the "flow-through"Filter Plate Washer connected to a vacuum source that has been ... the remaining capture bead working suspension and store at 2-8°C with light protection. It can be used for setting up ...
... oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection The Journal of infectious ... Yakub I, Lillibridge KM, Moran A, Gonzalez OY, Belmont J, Gibbs RA, Tweardy DJ, Single nucleotide polymorphisms in genes for 2 ... Exemestane may be less detrimental than letrozole to bone health in women homozygous for the UGT2B17*2 gene deletion Breast ...
... oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple ... Kang, S., Lee, D., Kim, J., Capasso, A., Kang, H. S., Park, J. W., Lee, C. H. & Lee, G. H., 2020, In: 2D Materials. 7, 2, ... Rhim, J., Lee, J. M., Yu, B. M., Ban, Y., Cho, S. H. & Choi, W. Y., 2014, In: Journal of the Optical Society of Korea. 18, 5, p ... 2D MoSe2 Transistor with Polymer-Brush/Channel Interface. Jeong, Y., Park, J. H., Ahn, J., Lim, J. Y., Kim, E. & Im, S., 2018 ...
... oligoadenylate synthetases (OAS). Double-stranded RNA, thought to be derived from viral replication intermediates, activates ... the product of dsRNA-activated oligoadenylate synthetases (OASes), binds to ankyrin repeats near the amino terminus of RNase L ... linked oligoadenylates called 2-5A [ppp5(A2p5)2A]. The 2-5A binds to and activates RNase L which cleaves single stranded RNA ... triphosphorylated oligoadenylates with 2-5 bonds. But RNase L activity is not limited to viral RNA cleavage. RNase L plays a ...
... oligoadenylate synthetase 1 (OAS1) (see the Perspective by Schoggins). OAS1 stimulates RNase L to inhibit the virus with a ... used IFN-stimulated gene expression screening on human lung cells from which they identified a gene for 2′-5′- ... oligoadenylate synthetase 1 (OAS1) (see the Perspective by Schoggins). OAS1 stimulates RNase L to inhibit the virus with a ... used IFN-stimulated gene expression screening on human lung cells from which they identified a gene for 2′-5′- ...
... oligoadenylate synthetase 1 (OAS1), interferon-stimulated gene 12 (IFI27), interferon-induced protein 6-16 (G1P3), and ... Table 2 Salivary cortisol levels in high- versus low-lonely individuals. Full size table. ... Figure 2. Transcriptional activity of GR and NF-κB signaling pathways. TELiS bioinformatics analysis assessed trans- ... A 2-sample variant of TELiS [63] identified upstream signal transduction pathways driving differential gene expression [41]. ...
acyl-CoA synthetase medium chain fa.... ADAMTS1. 9510. ADAMTS1. ADAM metallopeptidase with thrombos.... ...
... oligoadenylate synthetase-like. 0.048. Human S100a11. S100 calcium binding protein A11 (calizzarin). 0.045. ... solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5. 0.011. ...
... oligoadenylate synthetase .... OLFML2B. 25903. OLFML2B. olfactomedin like 2B [Source:HGN.... ORAI2. 80228. ORAI2. ORAI calcium ... Please send your emails to [email protected] on or before Wednesday November 2, 2022... Thanks in advance for your ... GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP LI_PBMC_MENACTRA_AGE_18_45YO_ ... GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP GSE9006_TYPE_1_DIABETES_AT_DX ...
... synthetase and changes in immunoreactive pRB/p53 in human prostatic JCA-1 cells. Faiella L, Ng C, Hsieh TC, Wu JM, Mallouh C. ... oligoadenylate (2-5A) ... Bcl-2, and actin expression in the human promyelocytic HL-60 ... 1995 Jun;209(2):152-6. doi: 10.3181/00379727-209-43889. Proc Soc Exp Biol Med. 1995. PMID: 7770465 ... 2002 Oct;8(5):591-602. doi: 10.1089/107555302320825101. J Altern Complement Med. 2002. PMID: 12470440 ...
Levels of the antiviral mouse oligoadenylate synthetase (mOas)1g pathway and RNAse L were upregulated in the lungs of ... The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. ... The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells. ... Oligoadenylate synthetase plays a critical role in interferon-gamma inhibition of respiratory syncytial virus infection of ...
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse 2',5'-Oligoadenylate Synthetase 1 (OAS1) in serum, plasma and other biological fluids. (orbitalbiosciences.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse 2', 5'-Oligoadenylate Synthetase 1 (OAS1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
  • In cells expressing viral genes, CBD augmented expression of IFNγ, IFNλ1 and IFNλ2/3, as well as the 2'-5'-oligoadenylate synthetase (OAS) family members OAS1, OAS2, OAS3, and OASL. (bvsalud.org)
  • used IFN-stimulated gene expression screening on human lung cells from which they identified a gene for 2′-5′-oligoadenylate synthetase 1 (OAS1) (see the Perspective by Schoggins). (ox.ac.uk)
  • The pharmacodynamic variables were strongly stimulated by simultaneous administration of both IFNs: serum neopterin and beta-2 microglobulin levels (β 2 M), and stimulation of 2'-5' oligoadenylate synthetase (OAS1) mRNA expression. (biomedcentral.com)
  • Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia. (bvsalud.org)
  • The ISGs (MX1, IFITM1, OAS1/2, and ISG15) were found to be highly induced after 6 h, mimicing classic intermediate and late responses to IFNα (Fig. 1A). (vzonetvgh.com)
  • Levels of the antiviral mouse oligoadenylate synthetase (mOas)1g pathway and RNAse L were upregulated in the lungs of unchallenged hORMDL3 zp3-Cre mice. (aai.org)
  • Treatment of Friend erythroleukemia cells (FLC) with gamma interferon (IFN-γ) in the presence of anti-IFN-β antibodies reduces the effectiveness of the antiviral state and the induction of 2'-5'-oligoadenylate synthetase activity, indicating that the antiviral activity of IFN-γ in FLC is in part mediated by the production of IFN-β. (elsevier.com)
  • A number of the ISGs encode enzymes with antiviral functions, which includes 2,5oligoadenylate synthetase (2-5 OAS), protein kinase R (PKR), Mx, PML, p56, and many Has2 others (58). (iccc2014.org)
  • 2'-5' oligoadenylate synthetase-like 2 is a protein that in the house mouse is encoded by the Oasl2 gene. (wikipedia.org)
  • The first report of the successful use of in vitro transcribed (IVT) mRNA in animals was published in 1990, when reporter gene mRNAs were injected into mice and protein production was detected 5 . (nature.com)
  • Many proteins bind towards the EBERs including double-stranded RNA-activated proteins kinase (PKR) La antigen ribosomal proteins L22 2 oligoadenylate synthetase EBNA1 and retinoic acid-inducible gene I (RIG-I) [8]-[10]. (bioriental.net)
  • IFN-induced 2-5 OAS is also activated by dsRNA. (iccc2014.org)
  • Rotavirus mRNAs contain a type 1 cap structure at their 5' end that is added by the viral capping enzyme VP3, which is a multifunctional protein with all the enzymatic activities necessary to add the cap and also functions as an antagonist of the 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway. (stanford.edu)
  • The presence of the truncated 37-kDa RNase L in PBMC extracts is therefore likely to result, not only from the abnormal activation of inflammatory proteases, but also from a dysregulation in 2-5A synthetase induction or activation towards the preferential production of 2-5A dimers. (proteabiopharma.com)
  • Flo-1 cells showed early induction of pSTAT1 and IRF1 starting at 2 h after treatment, which was sustained over the 72 h time-course with a time-dependent decrease in IRF1 steady state levels (Fig. 1A). (vzonetvgh.com)
  • Defective IFNR and ICE messenger RNA (mRNA) expression and the IRF-1/IRF-2 (IRF-1/2) ratio in U87IR were less than those in U87MG. (eurekamag.com)
  • In the 114 patients treated with IFN-beta, prognostic factors included IFNR-mRNA, ICE-mRNA and the IRF-1/IRF-2 ratio. (eurekamag.com)
  • The enzyme polymerizes ATP into 2,5-linked oligoadenylates that, in turn, activate latent RNase L, which results in degradation of mRNA and rRNA. (iccc2014.org)
  • In addition, the phosphorylation of STAT3 was significantly downregulated by CBD and THC in THP-1 macrophages and HBECs, which was in turn attributed to the reduced phosphorylation of tyrosine kinase-2 (TYK2) by CBD and THC after LPS stimulation in these cells. (bvsalud.org)
  • C-C motif chemokine receptor like 2. (gsea-msigdb.org)
  • RT-PCR was also performed on U87MG, and 114 frozen human neuroectodermal tumor tissue samples from glioma patients treated with IFN-beta and primers specific to the interferon receptor (IFNR) and interleukin-1 beta converting enzyme (ICE, caspase-1) and common to interferon regulatory factor (IRF)-1 and IRF-2. (eurekamag.com)
  • Dissecting effectivity of a 5′ quick amplification of cDNA ends (5′-RACE) technique for profiling T-cell receptor beta repertoire Deep sequencing of T-cell receptor (TCR) genes is extremely efficient at profiling immune repertoire. (master-sistemisanitari-medicinenonconvenzionali.org)
  • AIMS: To study effects on cellular innate immune responses to ORF8, ORF10, and Membrane protein (M protein) from the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19, in combination with cannabidiol (CBD). (bvsalud.org)
  • CBD similarly enhanced the cellular anti-viral response to Poly (I:C). SIGNIFICANCE: Our results demonstrate a poor ability of HEK293 cells to respond to SARS-CoV-2 genes alone, but an augmented innate anti-viral response to these genes in the presence of CBD. (bvsalud.org)
  • The addition of caps at their 5' RNA ends is an efficient mechanism not only to ensure escape from detection by the innate immune system but also to ensure the efficient synthesis of viral proteins. (stanford.edu)
  • Korennykh, A., "Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes. (princeton.edu)
  • boost our immune system, 2. (infraredsauna.com)
  • COVID-19 Immunology: A new study by German researchers from the Ludwig Maximilian University of Munich (LMU), University of Bonn and the Technical University of Munich has found that SARS-CoV-2 reduces the numbers and functional competence of certain types of immune cells in the blood, ie dendritic cells and affect responses to secondary infections. (thailandmedical.news)
  • New Immune Evasive SARS-CoV-2 B.1.620 Lineage Originating From Central Africa Now Silently Spreading Globally, Just In Time For Halloween! (thailandmedical.news)
  • A large body of epidemiological research has linked characteristics of the social environment to human physical health [ 1 , 2 ], but the genomic mechanisms of these effects remain largely unexplored. (biomedcentral.com)
  • Whether all 5' ends of the positive-sense genomic RNAs contained in the mature viral particles are modified by a cap structure is unknown. (stanford.edu)
  • integrin subunit alpha 5 [Source:HG. (gsea-msigdb.org)
  • Activated PKR in turn phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2). (iccc2014.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fatty Acid Transport Protein 5 (FATP5) in Tissue homogenates, cell lysates and other biological fluids. (lotusbiotechnologies.com)
  • Proceedings of the National Academy of Sciences of the United States of America 2013, 110 (5), 1652-1657. (princeton.edu)
  • Korennykh, A., "Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase. (princeton.edu)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Fatty Acid Transport Protein 5 (FATP5) in samples from tissue homogenates or other biological fluids. (lotusbiotechnologies.com)
  • Discrimination between IRF-1 and IRF-2 was achieved by digestion with the restriction enzyme EcoT221. (eurekamag.com)
  • PKR and 2-5 OAS are present in most cells at basal levels even in the absence of IFN (58). (iccc2014.org)
  • Whole Exome Sequencing in BRCA1-2 Candidate Families: The Contribution of Other Cancer Susceptibility Genes. (cdc.gov)
  • We found that, independent of the relative proportions of capped/noncapped RNAs present in rotavirus-infected cells, there were similar proportions of these two kinds of 5'-modified positive-sense RNAs in the viral particles. (stanford.edu)
  • These buildings are conserved in the homologous (baboon) Herpesvirus RNAs (HVP-1 and -2) [7] recommending they are crucial for the EBERs relationship with specific protein and their function. (bioriental.net)
  • American scientists from the University of Utah Health are leading a new urgent effort to determine if salivary glands infected with the SARS-CoV-2 virus that causes COVID-19 could diminish a person's long-term immunity to the disease after being immunized or after recovering from the illness. (thailandmedical.news)
  • The RNA genome is capped at the 5 end and polyadenylated at the 3 end. (iccc2014.org)
  • Approximately two-thirds of the 5 end of the genome consists of two overlapping open reading frames (ORF1a and ORF1b) that are translated as two polyproteins that are co- and posttranslationally processed by virus-encoded proteinases into as many as 16 nonstructural proteins (NSPs), including the RNA-dependent RNA polymerase. (iccc2014.org)
  • We showed, via a noninvasive in vivo imaging system, that RV intestinal replication peaked at days 2 to 5 post infection. (stanford.edu)
  • Taken together, our results indicate that homodimerization of RNase L by 2-5A oligomers higher than the dimer prevents its cleavage by proteolytic enzymes. (proteabiopharma.com)
  • Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. (medchemexpress.cn)
  • Features that varied more than 2-fold (with a coefficient of variance less than 30%) between normal and Figla null gonads were selected for further analysis. (biomedcentral.com)
  • The M (mean log ratio) vs. A (average log 2 signal value) scatter plots reflect the fold change of differentially expressed genes in Figla null and normal ovaries on the Y axis relative to their abundance on the X axis (Fig. 1 ). (biomedcentral.com)
  • KEY FINDINGS: Reduced cell number and increased early and late apoptosis were found when expression of viral genes was combined with 1-2 µM CBD treatment, but not in control-transfected cells treated with CBD, or in cells expressing viral genes but treated only with vehicle. (bvsalud.org)
  • collagen type IV alpha 2 chain [Sou. (gsea-msigdb.org)
  • IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . (medchemexpress.cn)