A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD.
A child who is receiving long-term in-patient services or who resides in an institutional setting.
Hallucinogenic alkaloid isolated from the flowering heads (peyote) of Lophophora (formerly Anhalonium) williamsii, a Mexican cactus used in Indian religious rites and as an experimental psychotomimetic. Among its cellular effects are agonist actions at some types of serotonin receptors. It has no accepted therapeutic uses although it is legal for religious use by members of the Native American Church.
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
A group of compounds that are methyl derivatives of the amino acid TYROSINE.
Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise.
The measure of the level of heat of a human or animal.
The processes of heating and cooling that an organism uses to control its temperature.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
A condition caused by the failure of body to dissipate heat in an excessively hot environment or during PHYSICAL EXERTION in a hot environment. Contrast to HEAT EXHAUSTION, the body temperature in heat stroke patient is dangerously high with red, hot skin accompanied by DELUSIONS; CONVULSIONS; or COMA. It can be a life-threatening emergency and is most common in infants and the elderly.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Organizations which are not operated for a profit and may be supported by endowments or private contributions.
Exclusive legal rights or privileges applied to inventions, plants, etc.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
Substances or materials used in the course of housekeeping or personal routine.
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.
The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.
The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.
An adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
The end-result or objective, which may be specified or required in advance.
Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.
Agents that improve the ability to carry out activities such as athletics, mental endurance, work, and resistance to stress. The substances can include PRESCRIPTION DRUGS; DIETARY SUPPLEMENTS; phytochemicals; and ILLICIT DRUGS.
Illegitimate use of substances for a desired effect in competitive sports. It includes humans and animals.
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.
An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons and has been used for that purpose experimentally.
A branch of law that defines criminal offenses, regulates the apprehension, charging and trial of suspected persons, and fixes the penalties and modes of treatment applicable to convicted offenders.
Persons who have committed a crime or have been convicted of a crime.
The branch of psychology which investigates the psychology of crime with particular reference to the personality factors of the criminal.
A violation of the criminal law, i.e., a breach of the conduct code specifically sanctioned by the state, which through its administrative agencies prosecutes offenders and imposes and administers punishments. The concept includes unacceptable actions whether prosecuted or going unpunished.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
Organized efforts to insure obedience to the laws of a community.
A legal concept that an accused is not criminally responsible if, at the time of committing the act, the person was laboring under such a defect of reason from disease of the mind as not to know the nature and quality of the act done or if the act was known, to not have known that what was done was wrong. (From Black's Law Dictionary, 6th ed)
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
Duties that are based in ETHICS, rather than in law.
The enactment of laws and ordinances and their regulation by official organs of a nation, state, or other legislative organization. It refers also to health-related laws and regulations in general or for which there is no specific heading.
Payments or services provided under stated circumstances under the terms of an insurance policy. In prepayment programs, benefits are the services the programs will provide at defined locations and to the extent needed.
Laws and regulations, pertaining to the field of medicine, proposed for enactment or enacted by a legislative body.
A psychoanalytic term meaning self-love.
Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.
A publication issued at stated, more or less regular, intervals.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. (From Merck Index, 11th ed)
A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.
2,5-Dimethoxy-4-methylamphetamine, a psychedelic drug also known as DOM or STP ... STP, a slang name for the psychedelic 2,5-Dimethoxy-4-methylamphetamine ...
42 (4): 223-4. doi:10.1016/S1355-0306(02)71832-7. PMID 12632938. de Boer D, Bosman I (2004). "A new trend in drugs-of-abuse; ... 43 (5): 1615-21. doi:10.1016/j.jpba.2006.11.037. PMID 17207601. Venhuis BJ, Blok-Tip L, de Kaste D (2008). "Designer drugs in ... Some compounds such as 2C-B and 5-Meo-DiPT did eventually increase in popularity to the point that they were sold in pill form ... 5 November 2009. "2009 Annual report: the state of the drugs problem in Europe" (PDF). Lisbon: European Monitoring Centre for ...
Jarnow, Jesse (December 5, 2019). "Owsley Stanley's 'Sonic Journals': Inside the Tape Vault of a Psychedelic Legend". Rolling ... March 4, 2000. Archived from the original on April 13, 2009. Retrieved May 26, 2010. Kamiya, Gary (March 14, 2000). " ... ISBN 1-58008-547-4. Perry, Charles (1984). The Haight-Ashbury: A History (PDF). Random House. ISBN 0-394-41098-X. Retrieved ... "Complete transcript of Donald Fagen and Walter Becker in a BBC-Online Chat, March 4, 2000". BBC. ...
4)‎ . . Night of Champions (2010) ‎ (→‎Results) *12:39, 10 December 2010 (diff , hist) . . (0)‎ . . Dalek ‎ (→‎Movement: (minor ... 2)‎ . . Shao Kahn ‎ (→‎Origins) *12:41, 14 November 2010 (diff , hist) . . (0)‎ . . Scouting in Alabama ‎ (→‎Black Warrior ... 2)‎ . . Grit (newspaper) ‎ (→‎Comic strips: minor spelling correction) *15:43, 14 June 2010 (diff , hist) . . (-5)‎ . . Matt ... 12:16, 2 June 2010 (diff , hist) . . (+10)‎ . . Washington Naval Treaty ‎ (→‎Terms: grammar...missing word in the sentence) ...
Beatrice (also known as MDO-D, MDOM, 2C-D, and 4-methyl-2,5-dimethoxymethamphetamine) is a lesser-known psychedelic drug. It is ... 4-Methylmethamphetamine Phenethylamine Psychedelics, dissociatives and deliriants Ganesha (psychedelic) Beatrice Entry in ... 5-dimethoxy-4-methylamphetamine (DOM). Beatrice was first synthesized by Alexander Shulgin. In his book PiHKAL, the minimum ... a substituted methamphetamine and a homolog of 2, ...
... , or 4-bromo-2,5-dimethoxy-N-methylamphetamine, is a lesser-known psychedelic drug. It is similar in structure to DOB ...
2-TOM and 5-TOM are the 2- and 5-methylthio analogs of 2,5-dimethoxy-4-methylamphetamine (DOM), respectively. They were first ... hallucinations Phenethylamine TOMSO 2-TOM entry in PiHKAL 5-TOM entry in PiHKAL v t e. ...
124 (2): 195-206. doi:10.1016/j.pharmthera.2009.07.001. PMC 2785038. PMID 19619582. Jiao D, Liu Y, Li X, Liu J, Zhao M (2015 ... 2 (Suppl 2588): 101-2. PMC 1974659. PMID 13182277. "Amphetamine drug profile , www.emcdda.europa.eu". www.emcdda.europa.eu. ... 65 (4): 705-10. doi:10.1016/s0091-3057(99)00263-4. PMID 10764926. Fischer A (2013). Link between amphetamine-type stimulant use ... 9 (4): 739-52. doi:10.1007/s13311-012-0150-9. PMC 3480574. PMID 23065655. "Narcolepsy Fact Sheet , National Institute of ...
26 (5): 274-281. doi:10.1016/j.tips.2005.03.007. PMID 15860375. Wang X, Li J, Dong G, Yue J (February 2014). "The endogenous ... 26 (5): 274-281. doi:10.1016/j.tips.2005.03.007. PMID 15860375. The pharmacology of TAs might also contribute to a molecular ... 187 (2): 365-71. PMID 4748552. Godfrey, Peter D.; Hatherley, Lynette D.; Brown, Ronald D. (1 August 1995). "The Shapes of ... 116 (2): 164-176. doi:10.1111/j.1471-4159.2010.07109.x. PMC 3005101. PMID 21073468. Sabelli, HC; Mosnaim, AD; Vazquez, AJ; ...
5-Dimethoxy-4-methylamphetamine or DOM/STP, a psychedelic phenethylamine Dioctyl maleate, a chemical compound used in the ... an alternative to traditional computer hard disk drives 2, ...
5-Dimethoxy-4-methylamphetamine Methyl-DMA Mirogabalin Octyl cyanoacrylate 2-Octyl cyanoacrylate Psi-DOM This set index page ... Bamethan 2CD-5EtO 2C-E 2C-G Dimethoxymethamphetamine 2, ...
... dl-2,5-dimethoxy-4-methylamphetamine a.k.a. DOM), entactogens (e.g., 3,4-methylenedioxyamphetamine a.k.a. MDA), appetite ... a novel N-2-methoxybenzyl-phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic ...
2,5-dimethoxy-4-bromophenethylamine) (2C-B) 5-(2-Aminopropyl)-2,3-dihydro-1H-indene (5-APDI, IAP) 6-(2-Aminopropyl)benzofuran ( ... Nichols, D.E., Hoffman, A.J., Oberlender, R.A., Jacob P 3rd & Shulgin A.T. Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine ... 4 (1). Retrieved 8 January 2015. Malamud, Ozer, Yvette; Yuri, Ito (2010-01-01). Encyclopedia of emotion. Greenwood Press. ISBN ... 191 (2): 181-193. doi:10.1007/s00213-007-0703-5. ISSN 0033-3158. PMID 17297639. S2CID 40322032. F., Quenzer, Linda (2013-05-06 ...
6-dimethoxy positional isomer of DOM, known as Ψ-DOM, is also mentioned in PiHKAL as being active, as is the alpha-ethyl ... Both the 2- and 5- O-desmethyl derivatives 2-DM-DOM and 5-DM-DOM, and the 2- and 5- ethyl analogues 2-Et-DOM and 5-Et-DOM have ... 2,5-Dimethoxy-4-methylamphetamine (DOM; known on the street as STP, standing for "Serenity, Tranquility and Peace") is a ... DOM is a chiral molecule, and R-(−)-DOM is the more active enantiomer, functioning as a potent agonist of the serotonin 5-HT ...
6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. It was ... Thus, while several-fold less potent than its analogues 2-methyl-MDA and 5-methyl-MDA, and approximately half as potent as MDA ... In animal studies it substitutes for MBDB, MMAI, LSD, and 2,5-dimethoxy-4-iodoamphetamine (DOI), though not amphetamine, but ... 4-methylenedioxy-N-methylamphetamine (MDMA). 6-Methyl-MDA has IC50 values of 783 nM, 28,300 nM, and 4,602 nM for inhibiting the ...
6-dimethoxy positional isomer of DOM, known as Ψ-DOM, is also mentioned in PiHKAL as being active, as is the alpha-ethyl ... 2,5-Dimethoxy-4-methylamphetamine (DOM; known on the street as STP, standing for "Serenity, Tranquility and Peace") is a ... Both the 2- and 5- O-desmethyl derivatives 2-DM-DOM and 5-DM-DOM, and the 2- and 5- ethyl analogues 2-Et-DOM and 5-Et-DOM have ... DOM is a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are mediated by its agonistic ...
6-dimethoxy-4-methylamphetamine, is a hallucinogenic, psychedelic drug and a structural isomer of the better-known hallucinogen ... The 2,6-isomer of another similar drug 2C-D-FLY (see 2C-B-FLY) has also been made by David E. Nichols and found to be active, ... Indeed, any of the 2Cx or DOx series of drugs could alternatively be made as the 2,6-isomer and would still be expected to show ... The activity of Ψ-DOM (and Ψ-2C-T-4) demonstrates that the two methoxy groups on the psychedelic phenethylamines are not ...
Missing or empty ,title= (help) [1] (in Dutch) [2] on the official website of the Dutch government. ... No advertisement No hard drugs No entrance to coffee shops by persons under the age of 18 No sale of more than 5 grams of ... 4-hydroxybutyric acid) hemp oil (concentrate of plants from the Cannabis species (hemp) obtained by extraction of hemp or ... 4,5-trimethoxyamfetamine) zipeprol The esters and derivatives of ecgonine, which can be turned into ecgonine and cocaine; The ...
3-dimethoxy-4,5-methylenedioxyamphetamine) TeMA (2,3,4,5-tetramethoxyamphetamine) Not all of these chemicals are bioassayed in ... Many countries have banned the major substances for which this book gives directions for synthesis, such as 2C-B, 2C-T-2, and ... 2C-B (2,5-dimethoxy-4-bromophenethylamine) 2C-E (2,5-dimethoxy-4-ethylphenethylamine) 2C-T-2 (2,5-dimethoxy-4- ... They are found within the first book of PIHKAL, and are as follows: Mescaline (3,4,5-trimethoxyphenethylamine) DOM (2,5- ...
Primarily: MAO-B[3][4][5]. Other enzymes: MAO-A,[5][6] SSAOs (AOC2 & AOC3),[5][7] PNMT,[3][4][5] AANAT,[5] FMO3,[8][9] and ... Primarily: MAO-B[3][4][5]. Other enzymes: MAO-A,[5][6] SSAOs (AOC2 & AOC3),[5][7] PNMT,[3][4][5] AANAT,[5] FMO3,[8][9] and ... doi:10.1016/0031-9422(77)83004-5.. *^ a b c d e Irsfeld M, Spadafore M, Prüß BM; Spadafore; Prüß (September 2013). "β- ... 9 (2): 203-206. doi:10.1021/ol062610v. PMC 2593899. PMID 17217265.. *^ a b c Scassellati C, Bonvicini C, Faraone SV, Gennarelli ...
Methamphetamine (N-methylamphetamine) -CH3. -CH3. Ephedrine pseudoephedrine -CH3. -CH3. -OH ... 3,4,5-TMA (3,4,5-trimethoxyamphetamine, α-methylmescaline) -CH3. -O-CH3. -O-CH3. -O-CH3. ... MDEA (3,4-methylenedioxy-N-ethylamphetamine) -CH2-CH3. -CH3. -O-CH2-O- ... DOM (2,5-dimethoxy-4-methylamphetamine) -CH3. -O-CH3. -CH3. -O-CH3. ...
... , or 2,5-dimethoxy-N-methylamphetamine, is a lesser-known psychedelic drug. Methyl-DMA was first synthesized by ... InChI=1S/C12H19NO2/c1-9(13-2)7-10-8-11(14-3)5-6-12(10)15-4/h5-6,8-9,13H,7H2,1-4H3 Y ... InChI=1/C12H19NO2/c1-9(13-2)7-10-8-11(14-3)5-6-12(10)15-4/h5-6,8-9,13H,7H2,1-4H3 ...
N-methylamphetamine 派醋甲酯(Methylphenidate). N,α-butylene-β-methoxycarbonylphenethylamine ... 苯乙胺(英語:phenethylamine或PEA),或称β-苯乙胺、2-苯乙胺,是一種生物鹼與單胺類神經遞質。苯乙胺有一個结构异构体,即α-苯乙胺或称1-苯乙胺,α-苯乙胺有兩個立體異構體:(R)-(+)-1-苯乙胺與(S)-(-)-1-苯乙胺。在人腦 ... O-CH2-O-. CH3. 3,4-methylenedioxy-N-methylamphetamine 亞甲二氧甲基
The new article 2 in paragraph 9 asks Parties "to use their best endeavours" to apply "such measures of supervision as may be ... Article 2, Paragraph 4: If the World Health Organization finds: (a) That the substance has the capacity to produce (i) (1) A ... The U.S. Controlled Substances Act's 21 U.S.C. § 811(d)(4) implies that placing a drug in Schedule IV or V of the Act is ... Article 2 sets out a process for adding additional drugs to the Schedules. First, the World Health Organization (WHO) must find ...
Fenethylline Glutethimide Lefetamine Mecloqualone Methaqualone Methylamphetamine Methylphenidate Nalbuphine Nicocodine ... 2) Regulations 2009 (SI 122/2009) and Misuse of Drugs (Amendment) (No. 2) Regulations 2010 (SI 200/2010). The substances (and ... Schedule 8 (inserted by the 2007 Regulations) lists the drugs that can be prescribed by a registered nurse within schedules 2 ... 1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl)-pentanone (i.e. MDPV, added by 2010 Regulations) 1-Benzylpiperazine (added by 2010 ...
2β-Propanoyl-3β-(4-tolyl)-tropane (WF-11) • 2β-Propanoyl-3β-(2-naphthyl)-tropane (WF-23) • 2-Propanoyl-3-(4-isopropylphenyl)- ... 2β-(3'-phenylisoxazol-5'-yl)nortropane (FE-β-CPPIT) • N-(3'-Fluoropropyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl) ... 2-OH-NPA • A-86,929 • Ciladopa • Dihydrexidine • Dinapsoline • Dinoxyline • Doxanthrine Others: A-68,930 • A-77,636 • A-412,997 ... 2-Amino-1,2-dihydronaphthalene (2-ADN) • 2-Aminoindane (2-AI) • 2-Aminotetralin (2-AT) • 4-Benzylpiperidine (4-BP) • 5-Iodo-2- ...
2C-G-2, 2C-G-3, 2C-G-4, 2C-G-5, 2C-G-6, and 2C-G-N) 2C-H 2C-I 2CI-2EtO 2C-iP 2C-N 2C-O 2C-O-4 2C-P 2C-SE 2C-T 2CT-5EtO 2C-T-2 ... 2C-T-4 and Ψ-2C-T-4) 2CT-4-2EtO 2C-T-7 2CT-7-2EtO 2C-T-8 2C-T-9 2C-T-13 2C-T-15 2C-T-16 2C-T-17 2C-T-19, 2C-T-21 2C-TFM 2C-YN ... 657-690, doi:10.1007/3-540-26573-2_23, ISBN 9783540225652 Laprairie, R B; Bagher, A M; Kelly, M E M; Denovan‐Wright, E M ( ... 5-MeO-7,N,N-TMT 5-MeO-a,N-DMT, also known as 'α,N,O-TMS' 4-F-5-MeO-DMT 5-MeS-DMT 5-Me-MiPT, its psychedelic activity is ...
3-Dimethoxy-4,5-methylenedioxyamphetamine). *DOB. *DOB-FLY(英语:DOB-FLY) ... 二甲基色胺(N,N-Dimethyltryptamine,简称DMT),是一種色胺類致幻劑。它以痕量見於人體中,由色胺-N-轉甲基酶催化產生。通常会在冥想与禁食期间大量产生。其結構與血清素、褪黑激素相似,也與其他色胺
5-chloro-1-(1-[3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl]piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one ... "British medical journal 2 (6199): 1188. பப்மெட்:519355. *↑ Shindler JS, Finnerty GT, Towlson K, Dolan AL, Davies CL, Parkes JD ... DOM-USA-5 Study Group". Clinical therapeutics 20 (3): 438-53. doi:10.1016/S0149-2918(98)80054-4. பப்மெட்:9663360. ... 5-HT3 Antagonists. Alosetron • Azasetron • Bemesetron • Cilansetron • Clozapine • Dazopride • Dolasetron • Granisetron • ...
5-HT2C گیرنده. Agonists: Phenethylamines: ۲سی-بی • ۲سی-ای • ۲-سی-آی • ۲سی-تی-۲ • ۲سی-تی-۷ • ۲سی-تی-۲۱ • ۲٬۵-دی‌متوکسی-۴- ... 5-HT1A گیرنده. ضد اضطراب‌ها: آزاپیرون‌ها:آلنسپیرون • بینوسپیرون • بوسپیرون • انیلوسپیرون • اپتاپیرون • گپیرون • ایپزاپیرون • ... 5-HT1E گیرنده. Agonists: Lysergamides: Methysergide; Triptans: Eletriptan; Tryptamines: BRL-54443 • تریپت‌آمین. Antagonists: ... 5-HT5A گیرنده. Agonists: Lysergamides: ارگوتامین • ال‌اس‌دی; Tryptamines: 5-Carboxamidotryptamine; Others: والرنیک اسید. ...
6-dimethoxy positional isomer of DOM, known as Ψ-DOM, is also mentioned in PiHKAL as being active, as is the alpha-ethyl ... Both the 2- and 5- O-desmethyl derivatives 2-DM-DOM and 5-DM-DOM, and the 2- and 5- ethyl analogues 2-Et-DOM and 5-Et-DOM have ... 2,5-Dimethoxy-4-methylamphetamine (DOM; known on the street as STP, standing for "Serenity, Tranquility and Peace") is a ... DOM is a chiral molecule, and R-(−)-DOM is the more active enantiomer, functioning as a potent agonist of the serotonin 5-HT ...
6-dimethoxy positional isomer of DOM, known as Ψ-DOM, is also mentioned in PiHKAL as being active, as is the alpha-ethyl ... 2,5-Dimethoxy-4-methylamphetamine (DOM; known on the street as STP, standing for "Serenity, Tranquility and Peace") is a ... Both the 2- and 5- O-desmethyl derivatives 2-DM-DOM and 5-DM-DOM, and the 2- and 5- ethyl analogues 2-Et-DOM and 5-Et-DOM have ... DOM is a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. Its psychedelic effects are mediated by its agonistic ...
5-dimethoxy-4-methylamphetamine DOM on colonic temperature in the rat at various ambient temperatures Br J Pharmacol 1976 57(4 ... 4 The hypothermia induced by R- and S+-DOM was antagonized by methysergide but not by p-chlorophenylalanine PCPA or pimozide. ... 1976 Aug 21;57(4):547-50.. Beaton JM, Benington F, Bradley RJ, Kuhlemeier KV, Morin RD. "Stereospecific actions of 2,5- ... dimethoxy-4-methylamphetamine DOM on colonic temperature in the rat at various ambient temperatures" Br J Pharmacol. 1976 Aug ...
6-dimethoxy positional isomer of DOM, known as Ψ-DOM, is also mentioned in PiHKAL as being active, as is the alpha-ethyl ... 5-HT2A. *Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe ... Serotonin (5-HT). *Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me ... Serotonin (5-HT). *Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, ...
2,5-Dimethoxy-4-Methyl-Amphetamine: New Hallucinogenic Drug. By Patrick A. Cabe, Solomon H. Snyder, Louis Faillace, Leo ... Sulfur-Containing Nucleoside from Yeast Transfer Ribonucleic Acid: 2-Thio-5(or 6)-uridine Acetic Acid Methyl Ester ...
2,5-Dimethoxy-4-methylamphetamine, a psychedelic drug also known as DOM or STP ... STP, a slang name for the psychedelic 2,5-Dimethoxy-4-methylamphetamine ...
2016 Chapter 2 D. CHAPTER TWO - OFFENSE CONDUCT. PART D - OFFENSES INVOLVING DRUGS AND NARCO-TERRORISM. Historical Note: ... 5). • At least 1 KG but less than 3 KG of Heroin;. • At least 5 KG but less than 15 KG of Cocaine;. • At least 280 G but less ... At least 4 G but less than 7 G of LSD;. • At least 160 G but less than 280 G of Fentanyl;. • At least 40 G but less than 70 G ... at least 4 G but less than 5 G of "Ice";. • At least 40 G but less than 50 G of Amphetamine, or. at least 4 G but less than 5 G ...
This study examined the effects of feeding conditions on sensitivity to the direct-acting 5-HT(2A/2C) re … ... Restricted access to standard or high fat chow alters sensitivity of rats to the 5-HT(2A/2C) receptor agonist 1-(2,5-dimethoxy- ... This study examined the effects of feeding conditions on sensitivity to the direct-acting 5-HT(2A/2C) receptor agonist 1-(2,5- ... dimethoxy-4-methylphenyl)-2-aminopropane (DOM; 0.1-3.2 mg/kg) and the direct-acting dopamine D3/D2 receptor agonist quinpirole ...
4)‎ . . Night of Champions (2010) ‎ (→‎Results) *12:39, 10 December 2010 (diff , hist) . . (0)‎ . . Dalek ‎ (→‎Movement: (minor ... 2)‎ . . Shao Kahn ‎ (→‎Origins) *12:41, 14 November 2010 (diff , hist) . . (0)‎ . . Scouting in Alabama ‎ (→‎Black Warrior ... 2)‎ . . Grit (newspaper) ‎ (→‎Comic strips: minor spelling correction) *15:43, 14 June 2010 (diff , hist) . . (-5)‎ . . Matt ... 12:16, 2 June 2010 (diff , hist) . . (+10)‎ . . Washington Naval Treaty ‎ (→‎Terms: grammar...missing word in the sentence) ...
Ganja Information File #4 ganja5.drg 7740. Ganja Information File #5 ganjaasc.drg 9861. The Ganja Guide #1 gasbom.txt 3732. ... A High-Dose 2-CB Trip highdoc.ana 1408. How to Get Really Soaring High on Gatorade highs.txt 76467. Legal Highs: A Concise ... File 5 of 6 pikhal6.txt 228384. PiHKAL: The Chemical Story. File 6 of 6 pisslist.txt 26819. The Great Usenet Just-Say-NO-to- ... File 2 of 6 pikhal3.txt 215552. PiHKAL: The Chemical Story. File 3 of 6 pikhal4.txt 206316. PiHKAL: The Chemical Story. File 4 ...
5-MeO-AMT. Dimethyltryptamine. Phenethylamine. 2C-B-FLY. Mescaline. 2C-D. 2C-C. 2C-T-2. 2C-T-7. 2C-T-4. 2C-B. 2C-E. 2C-T-21. 2, ... 2-MDP. 2-MDP (U-23807A) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar ... The levo or (-) isomer is the active form of the drug.[1][2] It also has stimulant effects, having only around one third the ... Ibotenic acid is a powerful neurotoxin that is used as a brain-lesioning agent[1][2] and has shown to be highly neurotoxic ...
42 (4): 223-4. doi:10.1016/S1355-0306(02)71832-7. PMID 12632938. de Boer D, Bosman I (2004). "A new trend in drugs-of-abuse; ... 43 (5): 1615-21. doi:10.1016/j.jpba.2006.11.037. PMID 17207601. Venhuis BJ, Blok-Tip L, de Kaste D (2008). "Designer drugs in ... Some compounds such as 2C-B and 5-Meo-DiPT did eventually increase in popularity to the point that they were sold in pill form ... 5 November 2009. "2009 Annual report: the state of the drugs problem in Europe" (PDF). Lisbon: European Monitoring Centre for ...
4 Effects of a range of doses of 8-OH-DPAT alone and in combination with WAY-100,635 (0.3 mg/kg, SC) in rats trained with LSD ( ... Figure 4 illustrates the use of M100907 and WAY-100,635 to rationalize the effects of 8-OH-DPAT in rats trained with LSD as a ... 5-methoxy-N,N-dimethyltrypamine Against the background provided above implicating the 5-HT2A receptor as the primary site of ... 2000) and that the 5-HT2C receptor may play a significant role (Eckler et al. 2004; Winter et al. 2005b). Direct testing of the ...
Figure 4. All of the cell bodies of neurons containing serotonin are found in the brainstem, a primitive part of the brain that ... Figure 5. The picture of chemical neurotransmission shown in Figure 3 is complicated by the fact that the receptors in ... Figure 2. Although hallucinogenic drugs are grouped together by their tendency to elicit common psychic, somatic, and sensory- ... 2): LSD is an ergot derivative; mescaline and DOM are phenylethylamines; and Psilocin and DMT are indoleamines. However, as we ...
Case 4*Allen v. Purdue Pharma L.P. (Stamford, CT 2002) *Plaintiff alleges that Mrs. Allen took OxyContin and, as a direct and ... 5. Controlled Substances Act (CSA) *Enacted into law by the Congress of the United States as Title II of the Comprehensive Drug ... Case 2*Jenks v. State, Fla. Dist1991Summary Jenks and his wife, who both suffered from AIDS, were convicted of manufacturing ... Case 5*Doctor Guilty in OxyContin case (FL, 2002) *Dr. James Graves ,Floridas top OxyContin prescriber, was convicted of ...
See §1B1.3(a)(2) (Relevant Conduct). Where there is no drug seizure or the amount seized does not reflect the scale of the ...
Adult male rats were trained to discriminate DiPT (5 mg/kg, 15 min) from saline under a FR10 schedule. A dose-effect and time ... Rats learned to discriminate DiPT from saline in an average of 60 training sessions (30 drug and 30 saline). DiPT (0.5-5 mg/kg ... Titeler M, Lyon RA, Glennon RA (1988) Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for ... Shulgin AT, Carter MF (1980) N, N-Diisopropyltryptamine (DIPT) and 5-methoxy-N, N-diisopropyltryptamine (5-MeO-DIPT). Two ...
Looking for online definition of -dom in the Medical Dictionary? -dom explanation free. What is -dom? Meaning of -dom medical term. What does -dom mean?
Next Document: Antagonism of the behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) and quipazine by met.... ...
2) the possible hallucinogens involved in HPPD induction; (3) the clinical features of both HPPD I and II; (4) the possible ... psychiatric comorbidities; and (5) the available and potential therapeutic strategies. We searched PubMed to identify original ... N-methylamphetamine; LSD: lysergic acid diethylamide; JWH-122: 4-methyl-1-(naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone. ... Perphenazine (4-8 mg/day) [17,23], Sulpiride (50-100 mg/day) [23], and Zuclopenthixol (2-10 mg/day) [17,23], at very low doses ...
2) A substance is a controlled drug if the substance (the drug analogue ) is, in relation to a controlled drug listed in ... 2) A substance is also a border controlled drug if the substance (the drug analogue ) is, in relation to a border controlled ... 2) A substance is a controlled precursor if the substance is a salt or ester of a precursor listed in the table in subsection ( ... 2) A substance is a border controlled precursor if the substance is a salt or ester of a precursor listed in the table in ...
Planning My Day (5-Minute Meditation Video) Planning My Day (Picture) Reviewing My Day Or Week (5-Minute Meditation Video) Life ... BEING CLOSED TO EXPERIENCE" modified from "PID-5" by Kreuger RF, Derringer J, Markon KE, Watson D, Skodol AE and Between facets ... Antagonism" modified from "PID-5" by Kreuger RF, Derringer J, Markon KE, Watson D, Skodol AE and Between facets and domains: 10 ... Detachment" modified from "PID-5" by Kreuger RF, Derringer J, Markon KE, Watson D, Skodol AE and Between facets and domains: 10 ...
2 0.05 EPZ-5676 supplier and ** 0.01 vs. C; + 0.05 and ++ 0.01 vs. H2O2.; = 6C8 per group. Thus our data claim that metformin ... 4, and 0.01 vs. C; + 0.01 vs. H2O2; # 0.01 vs. Met; = 3 per each group. These data demonstrate that AMPK activation decreases ... For cutoff 5 and 5.75% genotypic testing using proviral DNA showed an identical sensitivity for X4 as RNA. We discovered that ... 2 0.01) at 300 M H2O2. Treatment of control cells with metformin alone exerted the utmost influence on AMPK phosphorylation at ...
It is unknown how many items of mail containing illegal drugs slipped through to Barker and Smiths homes, but on June 2, 2016 ... Inside the teenagers bedroom officers found lysergic acid and a drug known by its street name "DOM" (2,5-Dimethoxy-4- ... methylamphetamine). That same day police banged on Smiths front door - he wasnt home, but his parents were. ...
The Role of 5-Hydroxtryptamine J.Pharmacol.Exp.Ther. 1978 204(2):416-23 ... dimethoxy-4-methylamphetamine (DOM) and 2,5-dimethoxy-4- ethylamphetamine (DOET) were also carried out. Results Pre-treatment ... 1978;204(2):416-23.. Winter JC. "Stimulus Properties of Phenethylamine Hallucinogens and Lysergic Acid Diethylamide: The Role ... Maximum antagonism it group 1 occurred at 10 mg/kg while in group 2 it occurred at 3 mg/kg of CN. In group 3, pretreatment with ...
5-MeO-DMT) and its salts into schedule I of the Controlled Substances Act (CSA). This proposed action is based on a... ... is issuing this notice of proposed rulemaking to place the substance 5-methoxy-N,N-dimethyltryptamine ( ... Placement of 5-MeO-DMT Into Schedule I In accordance with 21 U.S.C. 811(b) of the CSA, DEA has gathered and reviewed the ... 1) 5-MeO-DMT has a high potential for abuse. (2)5-MeO-DMT has no currently accepted medical use in treatment in the United ...
2,5-dimethoxy-4-methylamphetamine (STP) and other powerful synthetic psychoactive drugs in the 1960s. In the early 1950s, the ...
2 In the form of leaf powder or tea, coca is taken for toothache, ulcers, rheumatism, asthma, and even malaria. Coca tea is ... 4 (1967): 11-13; H. B. M. Murphy, 0. Rios, and J. C. Negrete, The Effects of Abstinence and Retraining on the Chewer of Coca ... 4. Carlos Gutierrez-Noriega, El Cocaismo y la Alimentacion en el Peru, Anales de la Facultad de Medicina 31 (1948): 1-90; J. ... 5. Lester Grinspoon and James B. Bakalar, Cocaine: A Drug and Its Social Evolution (New York: Basic Books, 1976), pp. 120-29; ...
2. Disposal of stocks. Any person who does not desire or is not able to obtain a schedule I registration would be required to ... 4\ While law enforcement data is not direct evidence of abuse, it can lead to an inference that a drug has been diverted and ... 4. Its History and Current Pattern of Abuse: Abuse of PMMA was first documented in the late 1980s and associated with ecstasy ... 5. The Scope, Duration, and Significance of Abuse: PMMA abuse has been associated with ecstasy tablets and is used as a ...
5-dimethoxy-4- (n)-propylthiophenethylamine (2C-T-7), N-Benzylpiperazine (BZP), and 1- (3-trifluoromethylphenyl)piperazine ( ... is issuing this notice of proposed rulemaking to place 2, ... 2. Section 1308.11 is proposed to be amended by: a. ... 52872-52875 (4 pages) CFR:. 21 CFR 1308. Agency/Docket Number:. Docket No. DEA-247P. Document Number:. 03-22684. ... The CSA (21 U.S.C. 811(h)(2)) requires that the temporary scheduling of a substance expire at the end of one year from the date ...
  • The results indicate that R- and S+-DOM act at post-synaptic 5-hydroxytryptamine receptors. (erowid.org)
  • less is known about the impact of feeding conditions on the effects of drugs acting on serotonin (5-HT) receptors. (nih.gov)
  • The 5-HT 2A receptor appears to be the primary site of action with significant modulation by other serotonergic sites including 5-HT 2C and 5-HT 1A receptors. (springer.com)
  • The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis. (chemchart.com)
  • The current study explores the mechanisms by which activation of serotonin(2A) (5-HT(2A)) receptors increase production of cyclic guanosine monophosphate (cGMP) in slices of rat frontal cortex. (neurotransmitter.net)
  • Contrary to results in cortical slices, stimulation of 5-HT(2A) receptors in cells stably expressing this serotonin receptor did not alter cGMP levels. (neurotransmitter.net)
  • The present study shows that 5-HT(2A) receptors do not directly stimulate cGMP formation, but rather that 5-HT(2A) receptor-mediated cGMP production is dependent on extracellular glutamate activating NMDA receptors. (neurotransmitter.net)
  • Evidence for this theory includes findings such as the inhibitory effect of neuroleptics on the dopaminergic system as well as the direct correlation between the effectiveness of the drug and the affinity of the drug to Dopamine receptor, particularly D2 receptors [ 3 ][ 4 ]. (wikidot.com)
  • Here we examine the effect of various agonists and antagonists of 5-HT2/5-HT1C receptors on noradrenaline release in hippocampus of anaesthetized rats using microdialysis. (ox.ac.uk)
  • Spiperone (0.2 and 1 mg kg-1, s.c.), a 5-HT2/dopamine D2 receptor antagonist which has low affinity for 5-HT1C receptors, also antagonized the effect of DOI (0.5 mg kg-1, s.c. (ox.ac.uk)
  • Indeed, it was not until Heffter's ( 1896 ) isolation of mescaline in 1896 from the cactus, Lophophora williamsii , and the determination of its chemical structure (3,4,5-trimethoxyphenylethylamine) by Spath ( 1919 ) that a well-defined substance could be said to produce hallucinations. (springer.com)
  • These include dimethoxy-4-methylamphetamine, or DOM or STP,   which is a synthetic drug similar to mescaline. (verywellmind.com)
  • Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. (chemchart.com)
  • 2C-B (sometimes called bromomescaline) is a hallucinogenic phenethylamine, related structurally to mescaline and the lesser known phenethylamine analogs DOB (2, 5-dimethoxy-4 bromoamphetamine) and DOM (2, 5-dimethoxy-4-methylamphetamine). (ecstasy.com.ua)
  • Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. (chemchart.com)
  • Cellular mechanisms of serotonin 5-HT2A receptor-mediated cGMP formation: the essential role of glutamate. (neurotransmitter.net)
  • 2,5-Dimethoxy-4-ethylamphetamine (DOET, DOE, Hecate) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. (chemchart.com)
  • β-Methylphenethylamine (β-Me-PEA, BMPEA), or 1-amino-2-phenylpropane, is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. (chemchart.com)
  • Phenethylamine (PEA), also known as β-phenylethylamine (β-PEA) and 2-phenylethan-1-amine, is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans. (chemchart.com)
  • 2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug" (PDF). (wikipedia.org)
  • It is unknown how many items of mail containing illegal drugs slipped through to Barker and Smith's homes, but on June 2, 2016 an item of mail from Germany containing amphetamine sulphate was stopped at the border. (dailymercury.com.au)
  • Rats were trained using electric shock and made to acquire discrimination between the effects of M-HCl (10 mg/kg, groups 1 and 2 ) or d-amphetamine SO4 (0.8 mg/kg, groups 3 and 4) and saline. (erowid.org)
  • 2. L-lysine-d-amphetamine mesylate. (epo.org)
  • This request differed from the main request by the deletion of the term 'L-lysine-d-amphetamine hydrochloride' in independent claim 4 and the deletion of dependent claim 14, resulting in a renumbering of all subsequent claims. (epo.org)
  • As regards claim 4, there was no disclosure in the application as filed of the oral administration of L-lysine-d-amphetamine. (epo.org)
  • 5-methoxy-MDA) is a psychedelic and entactogen drug of the amphetamine class. (chemchart.com)
  • Death", "Dr. Death"), also known as 4-methoxyamphetamine (4-MA), is a designer drug of the amphetamine class with serotonergic effects. (chemchart.com)
  • 2,5-Dimethoxy-4-methylamphetamine (2C-E) is a psychedelic and a substituted amphetamine. (farwestmedications.com)
  • 2C-E (4-ethyl-2,5-dimethoxy) salt/powder:,2,5-Dimethoxy-4-methylamphetamine (2C-E) is a psychedelic and a substituted amphetamine. (eulegalchem.com)
  • The CNS activity initiated by substituted phenylisopropylamines covers a spectrum of physiological actions from the purely stimulant activity found in amphetamine to the purely hallucinogenic activity of 2,5-dimethoxy-4-methylamphetamine (DOM) [1,6-11]. (designer-drug.com)
  • Inside the teenager's bedroom officers found lysergic acid and a drug known by its street name "DOM" (2,5-Dimethoxy-4-methylamphetamine). (dailymercury.com.au)
  • Comparative Biochemistry and Physiology - C Toxicology and Pharmacology , 158 (4), 207-215. (elsevier.com)
  • [ 2 ] This suggests that while α-Et-DOM may lack hallucinogenic effects, it might potentially produce empathogenic effects similar to those of MDMA if used at higher dose ranges, beyond those trialled by Shulgin (the potency of α-Et-DOM in this study was similar to that of MDMA, 1.5 mg/kg, which would equate to a dose of ~100 mg in a human). (worldlibrary.net)
  • La MDMA ("ekstazo") sintezo publikigita en PIHKAL restas unu el la plej oftaj sekretaj metodoj de it fabrikado al tiu tago. (wikitrans.net)
  • MDMA (3, 4-methylenedioxymethampheta-mine) is a complex drug that makes simple classification difficult. (ecstasy.com.ua)
  • 2-CB is distantly related to MDMA ( ecstasy ). (ecstasy.com.ua)
  • A series of 2,5-phenethylamines, conjointly mentioned as 2Cs, have hallucinogenic effects, and lots of ar regular as unlawful substances. (highfarmbotanicals.com)
  • The I2 receptor agonists BU224, RS45041, tracizoline, and CR4056 all fully substituted for 5.6 mg/kg 2-BFI while idazoxan, S22687, 2,5-dimethoxy-4-methylamphetamine (DOM), and phenyzoline produced partial or no substitution. (rti.org)
  • 1. Recent electrophysiological studies have shown that 5-HT2/5-HT1C receptor agonists inhibit the electrical activity of noradrenergic neurones in the rat locus coeruleus. (ox.ac.uk)
  • STP was first synthesized and tested in 1963 by Alexander Shulgin, who was investigating the effect of 4-position substitutions on psychedelic amphetamines. (wikipedia.org)
  • Its psychedelic effects are mediated by its agonistic properties at the 5-HT2A receptor. (wikipedia.org)
  • Its psychedelic effects are mediated by its agonistic properties at the 5-HT 2A receptor. (wikipedia.org)
  • 2,5-Dimethoxy-4-Substituted Amphetamines "Green List: List of Psychotropic Substances Under International Control" (PDF) (23rd ed. (wikipedia.org)
  • First, we compared the efficacy and safety of the dopamine receptor antagonists, which were domperidone maleate and levosulpiride, in a 2 week treatment in functional dyspepsia, then investigated the efficacy and safety of cisapride tartrate in a 2 week treatment in those who were resistant to domperidone maleate or levosulpiride. (bvsalud.org)
  • The Dopamine hypothesis was originally proposed by Van Possum [ 2 ]. (wikidot.com)
  • It has also been shown that in drug naive Schizophrenic patients (patients who have never been medicated for Schizophrenia), there is an increase in dopamine synthesis and presynaptic storage in the striatal region of the brain [ 5 ]. (wikidot.com)
  • Sulpiride (50 mg kg-1, s.c.), a dopamine D2 receptor antagonist did not alter the response to DOI (0.5 mg kg-1, s.c.). 4. (ox.ac.uk)
  • Other precursor analogs chemically related to PCP include N-ethyl-1 phenylcyclohexylamine (PCE), 1-(1-phenyl-cyclohexyl)-pyrrolidine (PCP or PHP), and 1-(1-(2 thienyl-cyclohexyl)-piperdine (TPCP or TCP). (ecstasy.com.ua)
  • 3,4-Methylenedioxyamphetamine (MDA) in particular is a receptive parent compound for the molecular modifications which produce such homologs and analogs. (designer-drug.com)
  • Tests in which the drugs to be antagonized were LSD, 2,5- dimethoxy-4-methylamphetamine (DOM) and 2,5-dimethoxy-4- ethylamphetamine (DOET) were also carried out. (erowid.org)
  • DOM is a selective 5-HT2A, 5-HT2B, and 5-HT2C receptor partial agonist. (wikipedia.org)
  • DOM is a selective 5-HT 2A , 5-HT 2B , and 5-HT 2C receptor partial agonist . (wikipedia.org)
  • Both the non-selective 5-HT receptor agonist, quipazine (1 mg kg-1, s.c.), and the 5-HT-releasing agent, p-chloroamphetamine (2 mg kg-1, s.c.), decreased noradrenaline release in hippocampus and these effects were antagonized by pretreatment with ritanserin (0.4 mg kg-1, s.c.).5. (ox.ac.uk)
  • harmine (found in a South American vine)   and 5-MeO-DMT and bufotenine (which naturally occurs in the venom of certain toads). (verywellmind.com)
  • The R- and S+-isomers of 2,5-dimethoxy-4-methylamphetamine DOM produce a dose-dependent hypothermia in rats kept in the cold 6 degrees C. 2 This hypothermia was linearly dependent upon ambient temperature and the R--isomer was considerably more potent than the S+-isomer. (erowid.org)
  • Ibotenic acid is a powerful neurotoxin that is used as a 'brain-lesioning agent'[1][2] and has shown to be highly neurotoxic when injected directly into the brains of mice and rats. (pearltrees.com)
  • Adult male rats were trained to discriminate DiPT (5 mg/kg, 15 min) from saline under a FR10 schedule. (springer.com)
  • METHODS: The von Frey filament test was used to examine the antinociceptive effects of 2-BFI in complete Freund's adjuvant (CFA)-induced inflammatory pain in rats. (rti.org)
  • A two-lever drug discrimination paradigm in which rats were trained to discriminate 5.6 mg/kg (intraperitoneally) 2-BFI from its vehicle was used to examine the discriminative stimulus effects of 2-BFI. (rti.org)
  • Rats learned to reliably discriminate 5.6 mg/kg 2-BFI from saline. (rti.org)
  • METHODS: Adult male Wistar rats were divided into groups receiving the 5-HT2A agonist, 1,2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI), nitroglycerin, or normal saline. (neurotransmitter.net)
  • Analogues where the methoxy groups at the 2,5- positions of the aromatic ring have been altered have also been synthesised and tested as part of an effort to identify the binding mode of DOM at the 5-HT2A receptor. (wikipedia.org)
  • There exist six different TMAs that differ only in the position of the three methoxy groups: TMA, TMA-2, TMA-3, TMA-4, TMA-5, and TMA-6. (chemchart.com)
  • 5 -HT2A receptor activation and nitric oxide synthesis: a possible mechanism determining migraine attacks. (neurotransmitter.net)
  • Evidence that 5-HT2 receptor activation decreases noradrenaline release in rat hippocampus in vivo. (ox.ac.uk)
  • Our data suggest that in vivo, noradrenaline release in hippocampus is inhibited by 5-HT2 receptor activation. (ox.ac.uk)
  • Introduction: The aim of this investigation was to evaluate methods for increasing Caco-2 cell throughput for assessing drug intestinal absorption. (naver.com)
  • METHODS: The T102C polymorphism of the 5-HT2A receptor gene was studied. (neurotransmitter.net)
  • The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this notice of proposed rulemaking to place the substance 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and its salts into schedule I of the Controlled Substances Act (CSA). (federalregister.gov)
  • Sorace, A. , 19 Dec 2019 , Second Language Research 4 p. (ed.ac.uk)
  • This page was last edited on 4 March 2019, at 07:35. (bremer-bau-kontor.de)
  • If finalized as proposed, this action would impose the criminal sanctions and regulatory controls of schedule I substances under the CSA on the manufacture, distribution, dispensing, importation, exportation, and possession of 5-MeO-DMT. (federalregister.gov)
  • [2] According to David T. Courtwright, "the 1970 Controlled Substances Act was part of an omnibus reform package designed to rationalize, and in some respects to liberalize, American drug policy. (wikia.org)
  • The 2,6-dimethoxy positional isomer of DOM, known as Ψ-DOM, is also mentioned in PiHKAL as being active, as is the alpha-ethyl homologue Ariadne. (wikipedia.org)
  • Also 4- bromo-2,5-dimethoxypheethylamine or 2C-B, which is like ecstasy, and is sometimes classed as an entactogen rather than a hallucinogen. (verywellmind.com)
  • Pihkal: Chemical Love Story estas libro de Dr. Alexander Shulgin kaj Ann Shulgin kiu estis publikigita en 1991. (wikitrans.net)
  • 4-Methylpentedrone (also known as 4-MPD and 4-Methyl-α-methylamino-valerophenone), is a stimulant drug of the cathinone class that has been sold online as a designer drug. (bremer-bau-kontor.de)
  • Both the 2- and 5- O-desmethyl derivatives 2-DM-DOM and 5-DM-DOM, and the 2- and 5- ethyl analogues 2-Et-DOM and 5-Et-DOM have been tested, but in all cases were significantly less potent than the corresponding methoxy compound, showing the importance of the oxygen lone pairs in 5-HT2A binding. (wikipedia.org)
  • 2] Ibotenic acid. (pearltrees.com)
  • We therefore employed three previously characterized, chemically-distinct natural DOMs, as well as a commercially available humic acid (Aldrich, AHA), at circumneutral (7-8) and acidic pH (~ 5), to examine DOM effects on whole-body Na + concentration, unidirectional influx and efflux rates of Na + , and ammonia and urea excretion rates in Daphnia magna. (elsevier.com)
  • OBJECTIVE: To determine the effect of the 5-HT2A receptor in control of spinal nociception, cerebral circulation, and nitric oxide synthase (nNOS) expression in trigeminovascular neurons. (neurotransmitter.net)
  • and (5) the available and potential therapeutic strategies. (mdpi.com)
  • 1][2] It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison. (pearltrees.com)
  • Noradrenaline output also decreased in response to administration of the structural analogue of DOI, 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane (DOB: 1 mg kg-1, s.c.). 3. (ox.ac.uk)
  • A sensitive method for determining levels of [-]-2,5,-dimethoxy-4-methylamphetamine in the brain tissue. (naver.com)
  • La ĉi-suba teksto estas aŭtomata traduko de la artikolo PiHKAL article en la angla Vikipedio , farita per la sistemo GramTrans on 2016-06-06 08:40:17. (wikitrans.net)
  • [ citaĵo bezonis ] En 1994, du jarojn post kiam PIHKAL estis publikigita, la Drug Enforcement Administration (DEA) trudeniris la laboratorion de Shulgin kaj petis ke li turno super lia DEA licenco. (wikitrans.net)
  • Onset of the discriminative stimulus effects was within 5 min, and the effects dissipated within 4 h. (springer.com)
  • The data from groups 1 and 2 indicated a complete and specific antagonism by BC-105 of the stimulus effects of M Similar results were obtained with CN. (erowid.org)
  • Verapamil, nimodipine, and W-7 did not alter the discriminative stimulus effects of 2-BFI. (rti.org)
  • CONCLUSION: These results indicate that the antinociceptive effects of 2-BFI involve intracellular Ca(2+) elevation and/or downstream Ca(2+)/calmodulin signaling, whereas the discriminative stimulus effects of 2-BFI are mediated by a distinct, independent mechanism. (rti.org)
  • A reasonable compromise was to prepare standards with at least 4 deuterium atoms per molecule but with as few in excess of 4 as was convenient from a synthesis standpoint. (thevespiary.org)
  • 2) is there a suitable method of synthesis? (designer-drug.com)
  • Hallucinogens represent an enormous group of natural and synthetic agents [ 1 , 2 ]. (mdpi.com)
  • Second, and perhaps more important, these drugs display cross-tolerance - that is, a decrease efficacy of one drug taken shortly after another drug (e.g., 3, 4). (shroomery.org)
  • DiPT (0.5-5 mg/kg) produced dose-dependent increases in drug-appropriate responding (DAR) to 99 % (ED 50 = 2.47 mg/kg). (springer.com)
  • However, the peak of a standard corresponding to loss of deuterium, (M+3-2) + would correspond to the (M+1) + ion of the parent drug and would constitute an interference from the standard. (thevespiary.org)
  • As a recreational drug, 4-FA is sometimes sold along with related compounds such as 2-fluoroamphetamine and 4-fluoromethamphetamine. (chemchart.com)
  • Although it was developed by Boehringer Ingelheim as a central nervous system stimulant and pressor agent in the 1960s, it entered in the drug arena at an accelerated rate during the last 4 years causing intoxications, fatal or not. (bremer-bau-kontor.de)
  • Pholedrine (Paredrinol, Pulsotyl, Veritol), also known as 4-hydroxy-N-methylamphetamine (4-HMA), 4-hydroxymethamphetamine, and para-hydroxymethamphetamine, is a drug that stimulates the sympathetic nervous system. (chemchart.com)
  • 2. Subcutaneous administration of the 5-HT2/5-HT1C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI: 0.2 and 0.5 mg kg-1), caused a marked decrease (50% of pre-drug levels 60 min after injection) of noradrenaline in hippocampal dialysates which was long-lasting (greater than 120 min). (ox.ac.uk)
  • 1-4] each present problems in testing and evaluation of drug-induced activity. (designer-drug.com)
  • For example, the choice of animal species can affect the observed response to a given drug [2,5] and lead to results which appear contradictory. (designer-drug.com)
  • On a global scale, seizures of synthetic cathinones have been steadily increasing since first reported in 2010, and are one of the most commonly seized NPS 5 . (jove.com)
  • Although Sasha later wrote that his doctoral work was "uninspired" and "dull" (PiHKAL, Chapter 2), adjectives like these are commonly applied to graduate-school projects. (psychedelicfrontier.com)
  • The 32P-tagged oligonucleotide probes utilized had been hSIE (high affinity sis-inducible component through the c-gene, m67 variant, 5-AGCTTCATTTCCCGTAAATCCCTA) that binds Stat1 and Stat3 (31) and MGFe (mammary. (exposed-skin-care.net)
  • Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine. (neurotransmitter.net)
  • OBJECTIVE: To find out the significance of the 5-HT2A receptor gene polymorphism in migraine. (neurotransmitter.net)
  • CONCLUSION: The T102C polymorphism of the 5-HT2A receptor gene is not directly related to the increased risk of migraine. (neurotransmitter.net)
  • The associations between the genotypes of this gene and aura may suggest that 5-HT2A receptor gene polymorphism may be involved in determining the subtypes of or accompanying symptoms in the migraine disease. (neurotransmitter.net)
  • RESULTS: The L-type Ca(2+) channel blockers verapamil and nimodipine, the calmodulin antagonist W-7, and the internal Ca(2+) release inhibitor ryanodine all attenuated the antinociceptive effects of 2-BFI. (rti.org)
  • The results indicate that 5-HT(2A) receptor-mediated cGMP production could be at least partially attributed to potentiation of NMDA receptor-mediated cGMP formation. (neurotransmitter.net)
  • Richard Meyer, reprezentanto por San Francisco Field Division de DEA, deklaris en referenco al PIHKAL "estas nia opinio-tio those libroj-aro bela multaj kuirlibroj sur kiel fari kontraŭleĝajn medikamentojn. (wikitrans.net)
  • Agentoj rakontas al mi tion en sekretaj laboratorioj kiujn ili trudeniris, ili trovis kopiojn de tiuj libroj", sugestante ke la publikigo de PIHKAL kaj la fino de la licenco de Shulgin eble estis ligitaj. (wikitrans.net)
  • Ne ĉiuj tiuj kemiaĵoj estas bioasaieitaj en PIHKAL , kelkaj estas simple menciis. (wikitrans.net)
  • Antagonism of the behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) and quipazine by met. (biomedsearch.com)
  • OBJECTIVE: This study examined the effects of several inhibitors of Ca(2+) signaling mechanisms on two behavioral effects of the prototypical imidazoline I2 receptor ligand 2-(2-benzofuranyl)-2-imidazoline (2-BFI). (rti.org)
  • DOM (STP- Serenity, Peace, tranquility) 2, 5-dimethoxy-4-methylamphetamine is similar to LSD but the effects last longer. (findmugshots.com)
  • For cutoff 5 and 5.75% genotypic testing using proviral DNA showed an identical sensitivity for X4 as RNA. (exposed-skin-care.net)
  • In this study, we introduce a protocol for the presumptive identification of synthetic cathinones, employing three aqueous reagent solutions: copper(II) nitrate, 2,9-dimethyl-1,10-phenanthroline (neocuproine) and sodium acetate. (jove.com)