A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
An enzyme that catalyzes the transfer of phosphate from C-3 of 1,3-diphosphoglycerate to C-2 of 3-phosphoglycerate, forming 2,3-diphosphoglycerate. EC 5.4.2.4.
Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
An enzyme that catalyzes the conversion of 2-phospho-D-glycerate to 3-phospho-D-glycerate. EC 5.4.2.1.
An order of anaerobic, coccoid to rod-shaped methanogens, in the kingdom EURYARCHAEOTA. They are nonmotile, do not catabolize carbohydrates, proteinaceous material, or organic compounds other than formate or carbon monoxide, and are widely distributed in nature.
Any salt or ester of glycerophosphoric acid.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
An enzyme catalyzing the transfer of a phosphate group from 3-phospho-D-glycerate in the presence of ATP to yield 3-phospho-D-glyceroyl phosphate and ADP. EC 2.7.2.3.
An increase in the total red cell mass of the blood. (Dorland, 27th ed)
Measurement of hemoglobin concentration in blood.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Enzymes that catalyze the cleavage of a phosphorus-oxygen bond by means other than hydrolysis or oxidation. EC 4.6.
A phylum of ARCHAEA comprising at least seven classes: Methanobacteria, Methanococci, Halobacteria (extreme halophiles), Archaeoglobi (sulfate-reducing species), Methanopyri, and the thermophiles: Thermoplasmata, and Thermococci.
The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
Electrophoresis applied to BLOOD PROTEINS.
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.
The rate dynamics in chemical or physical systems.
ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.
Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.
Inorganic salts of phosphoric acid.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Facilities equipped to carry out investigative procedures.
ISBN 978-3-642-32033-0. Timm S, Mielewczik M, Florian A, Frankenbach S, Dreissen A, Hocken N, Fernie AR, Walter A, Bauwe H (17 ... 49 (3): 393-7. doi:10.1104/pp.49.3.393. PMC 365972. PMID 16657968. Ma Y, Hartman MM, Moroney JV (January 2013). " ... Since the discovery of its activity in plants, it has been purified within human cells and implicated in 2,3-DPG regulation. ... 208 (2): 602-9. doi:10.1016/0003-9861(81)90549-x. PMID 6266352. Badwey JA (April 1977). "Phosphoglycolate phosphatase in human ...
2,3-BPG, the reaction product of the Luebering-Rapoport pathway was first described and isolated in 1925 by the Austrian ... R. Juel: 2,3-Diphosphoglycerate: its role in health and disease. In: CRC Critical Reviews in Clinical Laboratory Sciences. 10(2 ... The concentration of 2,3-BPG varies proportionately with the pH, since it is inhibitory to catalytic action of ... 2,3-bisphosphoglycerate, the most concentrated organophosphate in the erythrocyte, forms 3-PG by the action of ...
210 (3): 971-81. doi:10.1111/j.1432-1033.1992.tb17502.x. PMID 1483480. Forterre P (June 2006). "DNA topoisomerase V: a new fold ... 44 (3): 197-208. doi:10.1007/s11084-014-9365-6. PMC 4669544. PMID 25351682. "InterPro". www.ebi.ac.uk. Retrieved 2021-04-23. ... The increased concentration of cyclic 2,3-diphosphoglycerate protects the methanogen, helping it survive in an environment that ... Methanopyrus kandleri has a high concentration of cyclic 2,3-diphosphoglycerate. This compound is often found in ...
The presence of 2,3-diphosphoglycerate within erythrocytes maintains the normal affinity of hemoglobin for oxygen. HBOCs do not ... As a significant amount of iron is removed by each autologous transfusion, an adequate time for recovery of not less than 3 ... of the Hypoxia inducing transcription factors HIF-1α and HIF-2α, and thus stabilizes these protein complexes. Under normal O2 ...
227 (3): 595-607. doi:10.1016/0005-2744(71)90010-6. PMID 4328052. Wang, Y; Wei, Z; Liu, L; Cheng, Z; Lin, Y; Ji, F; Gong, W (17 ... 7 (3): 1115-21. doi:10.1021/bi00843a032. PMID 5690561. Salameh J, Goyal N, Choudry R, Camelo-Piragua S, Chong PS (July 2012). " ... 26 (3): 393-9. PMC 1762627. PMID 4827367. Song, L; Xu, Z; Yu, X (August 2007). "Molecular cloning and characterization of a ... 2,3-bisphosphoglycerate is required a cofactor for dPGM. In contrast, the iPGM class is independent of 2,3-bisphosphoglycerate ...
Retrieved 3 November 2011. PHB Bolton-Maggs (Ed) D Poles et al. on behalf of the Serious Hazards of Transfusion (SHOT) Steering ... Retrieved 3 November 2011. Enten, G.; Dalvi, P.; Martini, N.; Kausch, K.; Gray, A.; Landrigan, M.; Mangar, D.; Camporesi, E. ( ... Retrieved 3 November 2011. "Circular of information for the use of human blood and blood components" (PDF). AABB. p. 11. ... Retrieved 3 November 2011. "The appropriate use of group O RhD negative red cells" (PDF). National Health Service. Archived ...
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2, p. 12. Atkinson, M. P.; Fontaine, M. J.; Goodnough, L. T.; Wein, L. M. (2012). "A novel allocation strategy for blood ... 56 (3): 238-77. doi:10.1093/jhmas/56.3.238. PMID 11552401. "Red Gold: the Epic Story of Blood". PBS. Archived from the original ... 21 (2): 271-89. doi:10.1016/j.bpa.2007.01.002. PMID 17650777. Bakalar, Nicholas (2013-03-11). "The Shelf Life of Donor Blood". ... 3 (1): 2. doi:10.1186/2110-5820-3-2. PMC 3575378. PMID 23316800. "Blood's Shelf Life May Be as Short as 3 Weeks - HealthLeaders ...
30 (2): 475-87. doi:10.1016/j.cll.2010.02.002. PMID 20513565. Cata, JP; Wang, H; Gottumukkala, V; Reuben, J; Sessler, DI (May ... In the immediate spin method, two drops of patient serum are tested against a drop of 3-5% suspension of donor cells in a test ... 3 (1): 2. doi:10.1186/2110-5820-3-2. PMC 3575378. PMID 23316800. Hod, EA; Zhang, N; Sokol, SA; Wojczyk, BS; Francis, RO; ... 21 (2): 271-89. doi:10.1016/j.bpa.2007.01.002. PMID 17650777. "Archived copy" (PDF). Archived from the original (PDF) on 2018- ...
3 (6): 347.. *^ Toy, Girardet, Hormann, Lahoti, McNeese, Sanders, and Yetman. Case Files: Pediatrics, Second Edition. 2007. ... 2% (people in hospital)[1]. Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood ... This drop in intracellular CO2 causes a rise in cellular pH which has a stimulating effect on glycolysis. Since the process of ... Bicarbonate, unlike CO2, has poor diffusion across the cellular membrane and therefore there is little change in intracellular ...
Other names in common use include diphosphoglycerate-polyphosphate phosphotransferase, and 1,3-diphosphoglycerate-polyphosphate ... In enzymology, a 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase (EC 2.7.4.17) is an enzyme that catalyzes the ... 36 (2): 426-9. PMID 5557827. Kukaev IS, Bobyk MA, Nikolaev NN, Sergeev NS, Uryson SO (1971). "[Polyphosphate-synthesizing ... Kulaev IS, Bobyk MA (1971). "[Detection in Neurospora crassa of a new enzyme--1,3-diphosphoglycerate: polyphosphate ...
... diphosphoglycerate phosphatase, 2,3-diphosphoglyceric acid phosphatase, 2,3-bisphosphoglycerate phosphatase, and glycerate-2,3- ... 233 (2): 350-4. PMID 13563500. RAPOPORT S, LUEBERING J (1951). "Glycerate-2,3-diphosphatase". J. Biol. Chem. 189 (2): 683-94. ... The systematic name of this enzyme class is 2,3-bisphospho-D-glycerate 2-phosphohydrolase. Other names in common use include 2, ... In enzymology, a bisphosphoglycerate phosphatase (EC 3.1.3.13) is an enzyme that catalyzes the chemical reaction 2,3-bisphospho ...
and was ranked in 2016 by U.S. News and World Report as one of the top 2-3% of cancer specialty centers nationwide. The Carter ... Retrieved May 2, 2008. Lynch, Gordon S. (November 30, 2010). "Sarcopenia - Age-Related Muscle Wasting and Weakness: Mechanisms ... 1935 - 1967 - Alfred Chanutin, Ph.D., professor and chair of biochemistry, discovered the role of red blood cell 2,3- ... diphosphoglycerate (2,3-DPG) in oxygen transfer from hemoglobin. This finding had enormous impact on the preservation of blood ...
... glyceraldehyde 3-phosphate MeSH D09.698.211.500 - chitosan MeSH D09.698.350.500 - inulin MeSH D09.698.360.041 - agar MeSH ... 3-o-methylglucose MeSH D09.408.348.700 - picrotoxin MeSH D09.408.348.800 - teniposide MeSH D09.408.348.820 - thioglucosides ... 3-o-methylglucose MeSH D09.408.514.700 - methylmannosides MeSH D09.408.620.569 - nucleoside diphosphate sugars MeSH D09.408. ... 3-diphosphoglycerate MeSH D09.811.522.050 - acetylmuramyl-alanyl-isoglutamine MeSH D09.811.589.668 - sialic acids MeSH D09.811. ...
2,3-BPG is formed from 1,3-BPG by the enzyme BPG mutase. It can then be broken down by 2,3-BPG phosphatase to form 3- ... 2,3-BPG is part of a feedback loop that can help prevent tissue hypoxia in conditions where it is most likely to occur. ... When 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier. It ... The concentration of 2,3-BPG varies proportionately to the [H+]. There is a delicate balance between the need to generate ATP ...
2,3-diphosphoglycerate), involved in hemoglobin-oxygen binding Dihydroxyphenylglycine, an amino acid Digital pair gain, a ...
The trade-off is all the more critical as Rubisco, the enzyme used to capture CO 2, is efficient only when there is a high ... 66 (2): 214. doi:10.1111/j.1365-2494.2010.00778.x. Lincoln Taiz and Eduardo Zeiger, A Companion to Plant Physiology Stoll, M.; ... At the same time as CO 2 enters the stomata, moisture escapes. This trade-off between CO 2 gain and water loss is central to ... ISBN 978-3-540-20833-4. Farrell, A. D.; Gilliland, T. J. (2011). "Yield and quality of forage maize grown under marginal ...
3 (12): 943-952. doi:10.1016/S2213-2600(15)00418-X. ISSN 2213-2619. PMID 26597128. Webb GJ, Smith K, Thursby-Pelham F, Smith T ... 10 (2): 69-76. PMID 22041604. "Nutrition support in adults: oral nutrition support, enteral tube feeding and parenteral ... Formation of phosphorylated carbohydrate compounds in the liver and skeletal muscle depletes intracellular ATP and 2,3- ... diphosphoglycerate in red blood cells, leading to cellular dysfunction and inadequate oxygen delivery to the body's organs. ...
85 (2): 117-22. doi:10.1002/ajh.21599. PMID 20052749.. *^ Heaton, A.; Keegan, T.; Holme, S. (1989). "In vivo regeneration of ... 56 (3): 238-77. doi:10.1093/jhmas/56.3.238. PMID 11552401.. *^ "Red Gold: the Epic Story of Blood". PBS. Archived from the ... 2, p. 12. *^ Atkinson, M. P.; Fontaine, M. J.; Goodnough, L. T.; Wein, L. M. (2012). "A novel allocation strategy for blood ... "Blood's Shelf Life May Be as Short as 3 Weeks - HealthLeaders Media". www.healthleadersmedia.com. Archived from the original on ...
... may refer to: 1,3-Diphosphoglycerate 2,3-Diphosphoglycerate This set index page lists chemical compounds ...
22 (3): 464-70. PMID 11330647. Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S ( ... 21 (2): 328-38. doi:10.1002/j.1939-4640.2000.tb02111.x (inactive 2021-01-13). PMID 10714828.CS1 maint: DOI inactive as of ... 8 (3): 350-7. PMID 4349855. Archived from the original (PDF) on 2015-09-23. Retrieved 2011-10-14. Maruyama K, Sugano S (Jan ... 6 (2): 127-36. doi:10.1093/molehr/6.2.127. PMID 10655454. Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG (2001). " ...
... syndrome Dionisi-Vici-Sabetta-Gambarara syndrome Diphallia Diphallus rachischisis imperforate anus Diphosphoglycerate mutase ... nephrogenic type 2 Diabetes insipidus, nephrogenic type 3 Diabetes insipidus, nephrogenic, dominant type Diabetes insipidus, ... congenital type 2 Dyserythropoietic anemia, congenital type 3 Dysferlinopathy Dysfibrinogenemia, familial Dysfibrinogenemia, ... nephrogenic, recessive type Diabetes mellitus Diabetes mellitus type 1 Diabetes mellitus type 2 Diabetes persistent mullerian ...
High levels of 2,3-BPG shift the curve to the right (as in childhood), while low levels of 2,3-BPG cause a leftward shift, seen ... As a result, 2,3-BPG binds more strongly to adult hemoglobin, causing HbA to release more oxygen for uptake by the fetus, whose ... The production of 2,3-BPG is likely an important adaptive mechanism, because the production increases for several conditions in ... At the placenta, there is a higher concentration of 2,3-BPG formed, and 2,3-BPG binds readily to beta chains rather than to ...
First, 2 molecules of formaldehyde are added to 2 molecules of the amino acid glycine. This produces two molecules of the amino ... Then these 3 molecules of DHA are phosphorylated to DHAP by triokinase. Like the other cycles, 3 C 3 {\displaystyle {\ce {C3 ... The other 2 molecules are used to regenerate xylulose 5-phosphate. As key players in the carbon cycle, methylotrophs work to ... 22 (2-3): 307-319. doi:10.1007/s00775-016-1419-y. ISSN 0949-8257. PMC 5352483. PMID 27878395. Hanson, R. S.; Hanson, T. E. ( ...
53 (2): 141-51. doi:10.1007/PL00000585. PMID 9118002. S2CID 24072481. Gribenko AV, Patel MM, Liu J, McCallum SA, Wang C, ... 224 (2): 427-40. doi:10.1016/0022-2836(92)91005-A. PMID 1313885. Stefani M, Taddei N, Ramponi G (February 1997). "Insights into ... Other names in common use include acetylphosphatase, 1,3-diphosphoglycerate phosphatase, acetic phosphatase, Ho 1-3, and GP 1-3 ... This enzyme participates in 3 metabolic pathways: glycolysis / gluconeogenesis pyruvate metabolism, and benzoate degradation ...
9-19 Rapoport, S. and J. Luebering: An Optical Study Of Diphosphoglycerate Mutase (From the Children's Hospital Research ... 3/2004 Goldenberg, H. : Nachruf Univ.-Prof. Dr. Samuel Mitja Rapoport (1912-2004) Newsletter vom 20.07.2004 Gesammelt vom ... 1997; 3: 1-55 (Heft 9) Marxismus, Exil und jüdische Identität. Der Biochemiker Samuel Mitja Rapoport. Jüdisches Echo 49 ( ... Thus the survivability of the bottled blood could be extended from 1 to 3 weeks. In 1948, together with two other American ...
Glyceraldehyde-3-phosphate GADP 3-Phosphoglyceraldehyde PGAL, G3P, GALP,GAP,TP 7 1,3-Bisphosphoglycerate 1,3BPG Glycerate-1,3- ... 3 (3): 3002-17. doi:10.3390/cancers3033002. PMC 3759183. PMID 24310356.. *^ Cox, David L. Nelson, Michael M. (2005). Lehninger ... 2-Phosphoglycerate3− → Phosphoenolpyruvate3− + H2O 1.8 1.1 10 Phosphoenolpyruvate3− + ADP3− + H+ → Pyruvate− + ATP4−. -31.7 - ... 17 (2): 164-170. doi:10.2174/1871520616666161031143301. PMID 27804847.. *^ Maroon, J; Bost J; Amos A; Zuccoli G (May 2013). " ...
Other articles where 2,3-diphosphoglycerate is discussed: blood: Respiration: …tissues and the content of 2,3- ... diphosphoglycerate (2,3-DPG) in red cells. The pH of blood is kept relatively constant at the slightly alkaline level of about ... tissues and the content of 2,3-diphosphoglycerate (2,3-DPG) in red cells. The pH of blood is kept relatively constant at the ... the blood), carbon dioxide, and 2,3-diphosphoglycerate (2,3-DPG; a salt in red blood cells that plays a role in liberating ...
2,3-DPG testing is done to help investigate both a deficiency in red blood cells (anemia) and an unexplained increase of red ... 2,3-Diphosphoglycerate Test Definition 2,3-diphosphoglycerate (2,3-DPG) is a substance made in the red blood cells. It controls ... Source for information on 2,3-Diphosphoglycerate Test: Gale Encyclopedia of Medicine, 3rd ed. dictionary. ... www.encyclopedia.com/medicine/encyclopedias-almanacs-transcripts-and-maps/23-diphosphoglycerate-test ...
To investigate a possible mechanism involved in the regulation of 2,3-diphosphoglycerate (2,3-DPG) synthesis, 2,3-DPG mutase ( ... DPGM) was measured in different mammals presenting large differences in 2,3-DPG concentration between fetal, neonatal and ad ... The data demonstrated that the minimal levels of 2,3-DPG in the adult sheep are likely due to the very low levels of DPGM. Also ... 2,3-Diphosphoglycerate. Aging. Animals. Animals, Newborn. Bisphosphoglycerate Mutase / blood*. Diphosphoglyceric Acids / ...
... diphosphoglycerate in the Medical Dictionary? 2,3-bisphosphoglycerate, diphosphoglycerate explanation free. What is 2,3- ... bisphosphoglycerate, diphosphoglycerate? Meaning of 2,3-bisphosphoglycerate, diphosphoglycerate medical term. What does 2,3- ... diphosphoglycerate. 2,3-bisphosphoglycerate, diphosphoglycerate. a product of glucose metabolism; binds strongly to ... 2,3-bisphosphoglycerate, diphosphoglycerate , definition of 2,3-bisphosphoglycerate, diphosphoglycerate by Medical dictionary ...
... Hess, J R ... 2;3-Diphosphoglycerate/*analysis, Adenosine Triphosphate/*analysis, Biological Markers/analysis, Blood Preservation/*standards ...
Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the ... KM=5.8 mM for 2,3 diphosphoglycerate (at pH 7.0 and 83 degrees Celsius)2 Publications. Manual assertion based on experiment ini ... 2 Publications. ,p>Manually curated information for which there is published experimental evidence.,/p> ,p>,a href="/manual/ ... KM=3.0 mM for ATP (at pH 7.0 and 83 degrees Celsius)2 Publications. Manual assertion based on experiment ini ...
The substitution affects one of the 2, 3-diphosphoglycerate bind … ... The substitution affects one of the 2, 3-diphosphoglycerate binding sites, resulting in an increased affinity for oxygen, but ... Haemoglobin Rahere (beta Lys-Thr): A new high affinity haemoglobin associated with decreased 2, 3-diphosphoglycerate binding ...
LICHTMAN MA, MILLER DR, COHEN J, WATERHOUSE C. Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate ... A marked reduction in red cell glucose utilization, lactate production, and 2,3-diphosphoglycerate and adenosine triphosphate ... Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate Concentration, and Increased Hemoglobin-Oxygen ...
2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension. The Journal of the American ... Hicks J, Will D. 2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension. J Am Osteopath ... 2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension ... 2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension ...
Results Mean 2,3-DPG levels decreased from a mean (±SD) of 13.4±3.4 µmol/g Hgb to 11.0±3.1 µmol/g Hgb after 2 days of CRRT (P, ... 2,3-DPG Levels on Days 0 and 2. The baseline mean 2,3-DPG levels were 13.4±3.4 µmol/g Hgb in the CRRT cohort and 11.6±1.9 µmol/ ... 2,3-DPG increased by 0.56 µmol/g Hgb per 1-mmHg increase in P50 in the CRRT cohort (95% CI, 0.48 to 0.57; P,0.001). Among ... After 2 days, 2,3-DPG levels decreased in the CRRT cohort to 11.0±3.1 µmol/g Hgb (P,0.001) but did not significantly change in ...
... diphosphoglycerate and oxygen affinity Red cell 2 3diphosphoglycerate and oxygen affinity Red cell 2 3diphosphoglycerate and ... red cell 2 3 DPG level Can you superimpose on the graph the oxygen dissociation curve for foetal haemoglobin? The HbF curve is ... 2 3. A definition of the term 2 3-diphosphoglycerate which refers to an organic phosphate in red blood cells is presented ... Red cell 2 3. Red cell 2 3-diphosphoglycerate and oxygen affinity MacDonald R The ease with which haemoglobin releases oxygen ...
A reduction in red cell ATP was also present and persisted for 5 days during which time red cell 2,3-DPG returned to levels ... A significant fall in 2,3-DPG and an increase in hemoglobin-oxygen affinity was present in red cells of patients studied on the ... The reduction in serum inorganic phosphorous followed the reduction in red cell 2,3-DPG and correlated with the reduction in ... Neither the transfusion of stored blood nor the effect of cardiopulmonary bypass fully explained the reduction in red cell 2,3- ...
3. Itano, H. A., Singer, S. J., and Robinson, E., "Ciba Found. Symp. Human Biochemical Genetics", (Churchill, London, 1959; in ... 2. Singer, S. J., and Itano, H. A., Proc. U.S. Nat. Acad. Sci., 45, 174 (1959). ... Structure of the Felidae hemoglobins and response to 2,3-diphosphoglycerate *F. Taketa ...
Should We Monitor ScVO(2) in Critically Ill Patients?. Sep 24, 2011·Cardiology Research and Practice·Sophie Nebout, Romain ... On the other hand, there existed no correlation between P50 std or 2,3-DPG, and Pao2, Paco2 and phosphoremia. The Hill number ... Oxygen affinity of haemoglobin and red cell 2,3-diphosphoglycerate in childhood diabetes. (opens in new tab) ... Hemoglobin dissociation curve and 2,3-diphosphoglycerate in erythrocytes in septic shock. Annales Françaises Danesthèsie Et De ...
2,3-diphosphoglycerate: a physiological inhibitor of platelet aggregation. By SG Iatridis, PG Iatridis, SG Markidou, BH Ragatz ...
Regulation of linkages between the erythrocyte membrane and its skeleton by 2,3-diphosphoglycerate.. Moriyama R, Lombardo CR, ... Number of papers published in 1993: 3. * Yeast origin recognition complex is involved in DNA replication and transcriptional ... In addition to reducing hemoglobin-O2 affinity, 2,3-diphosphoglycerate (DPG) is known to modulate the mechanical properties of ... The inhibition was biphasic, similar to the band 3-DPG binding isotherm; however, at physiological DPG concentrations a ...
2,3-diphosphoglycerate (2,3-DPG) levels were significantly decreased in AD and NA patients. The pattern of changes between ... Collectively, our data suggested that AD and NA patients are associated with chronic disturbance of 2,3-DPG metabolism in RBCs ... 2,3-diphosphoglycerate (2,3-DPG) levels were significantly decreased in AD and NA patients. The pattern of changes between ... Collectively, our data suggested that AD and NA patients are associated with chronic disturbance of 2,3-DPG metabolism in RBCs ...
... diphosphoglycerate (2,3-DPG) concentration in the red blood cell. Increased intracellular 2,3-DPG decreases oxygen binding and ... 2,3-DPG is an intermediate substrate in the glycolytic pathway, the only source of ATP production in red blood cells. Pyruvate ... Single arm, intrapatient dose escalation Q 2 weeks. Drug: AG-348 All subjects will receive an initial dose of 5 mg BID of AG- ... RBC 2,3-DPG activities from baseline, 2,3-DPG, ATP levels at different doses of AG-348 and change from baseline etc. ...
Adenosine 3,5-Monophosphate in Pancreatic Islets: Glucose-Induced Insulin Release. By M. Arthur Charles, R. Fanska, Florence ... 2, x pp. + pp. 313-612, illus. Each vol., $14.95; the set, $24.50 ... 3-Diphosphoglycerate. By E. G. Brann, D. J. Newman, Frank A. ... Oxygen Affinity in Red Cells: Inability to Show Membrane-Bound 2, ...
2.. Pattern of mutation rates in the germline of Drosophila melanogaster males from a large-scale mutation screening experiment ... 1997;9(2):225-232. doi: 10.1002/(SICI)1520-6300(1997)9:2,225::AID-AJHB9,3.0.CO;2-Z. ... Gender and treatment differences in knowledge, health beliefs, and metabolic control in Mexican Americans with type 2 diabetes. ... Symptom-related self-care of Mexican Americans with type 2 diabetes: preliminary findings of the Starr County Diabetes ...
Exercise #2[edit]. *Mom brings in her 7 yo, 22 kg son for altered mental status. He was playing in the snow, bundled in 3-4 ... 4/2/1[edit]. *4 cc/kg/hr for each of the first 10 kg == ... Answer #2- Part I[edit]. *Crystalloid (NS or LR) ==. *22 kg x ... This page was last edited on 3 August 2017, at 03:19. ... Exercise #3[edit]. *10 yo M, 24 kg, with ongoing diarrhea ==. * ...
DIPHOSPHOGLYCERATE-2,3 Keyword (en). RED BLOOD CELL METABOLISM PHOSPHATES RAT BLOOD CELL BLOOD MAMMALIA RODENTIA Classification ... EFFECT OF 1,25-DIHYDROXYCHOLECALCIFEROL AND 1,25-DIHYDROXYCHOLECALCIFEROL GLYCOSIDE ON 2,3 DIPHOSPHOGLYCERATE LEVELS OF THE RAT ... 2;s:9:FAIENZA H;i:3;s:10:ORSATTI MB;i:4;s:8:PUCHE RC;i:5;s:9:BOLAND RL;i:6;s:9:SKLIAR MI;}s:9:\u0000*\ ... 2;s:9:FAIENZA H;i:3;s:10:ORSATTI MB;i:4;s:8:PUCHE RC;i:5;s:9:BOLAND RL;i:6;s:9:SKLIAR MI;}s:9:\u0000*\ ...
2:20-47.[PubMed] * Kreider R. B., Miller G. W., Williams M. H., Somma C. T., Nasser T. (1990) Effects of phosphate loading on ... 297(17): 901-3. * Rubin M. F., Narins R. G. (1990) Hypophosphatemia: Pathophysiological and practical aspects of its therapy. ... Cade R., Conte M., Zauner C., Mars D., Peterson J., Lunne D., Hommen N., Packer D. (1984) Effects of phosphate loading on 2,3- ... diphosphoglycerate and maximal oxygen uptake. Med Sci Sports Exerc. 16:263-268.[PubMed] ...
Yamaguchi K, Mori M, Kawai A, Yokoyama T. Influences of carbon monoxide on the binding of oxygen, carbon dioxide, proton and 2, ... In an attempt to estimate the influences of CO on the CO2 Bohr effect and the 2,3-diphosphoglycerate (DPG) effect linked to the ... N2 - In an attempt to estimate the influences of CO on the CO2 Bohr effect and the 2,3-diphosphoglycerate (DPG) effect linked ... AB - In an attempt to estimate the influences of CO on the CO2 Bohr effect and the 2,3-diphosphoglycerate (DPG) effect linked ...
The 2,3-diphosphoglycerate level was higher in patients with end-stage liver disease than in the controls. A 0.3 g/L increase ... The 2,3-diphosphoglycerate concentration showed a significant correlation with the PaO2, Ca-vO2, P50, and blood lactate level, ... End-stage liver disease is associated with an increase in the level of the erythrocyte 2,3-diphosphoglycerate and P50. This is ... 2,3-Diphosphoglycerate , Cardiac Output , Erythrocytes , Hemodynamics , Humans , Hydrogen-Ion Concentration , Lactic Acid , ...
Part 2 Whole Body Metabolism. Chapter 10 Nutrition: General Aspects. 10.1 Introduction 10.2 Components of an Adequate Diet. ... Chapter 3 Roles of Subcellular Organelles: Lysosomes. 3.1 Introduction. 3.2 Origin of Lysosomal Enzymes. 3.3 The Nature of the ... Part 3 Specialized Metabolism of Tissues. Chapter 24 Blood: Erythropoiesis-Role of Folate and Vitamin Β12. 24.1 Normal ... Chapter 2 Roles of Extracellular and Intracellular Membranes: Membrane Structure and Membrane Transport. 2.1 Introduction. 2.2 ...
3). Each band may represent symmetric α2βAβA and α2βBβB Hb tetramers along with a stable asymmetric hybrid α2βAβB tetramer of ... 2,3-diphosphoglycerate. Hb. hemoglobin. IEF. isoelectric focusing. n. cooperativity (Hill) coefficient. P50. O2 tension at half ... 2). The tandemly linked HBB/D and HBB genes share the same β2His→Phe substitution as in the domestic cat (Fig. 1B), as a result ... Hb-O2 equilibrium curves of big cats. Hb-O2 equilibrium curves of African lion (A) and snow leopard (B) HbA and HbB are ...
Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- ... bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity. ... "The complete amino acid sequence of human erythrocyte diphosphoglycerate mutase.". Haggarty N.W., Dunbar B., Fothergill L.A.. ... "The complete amino acid sequence of human erythrocyte diphosphoglycerate mutase.". Haggarty N.W., Dunbar B., Fothergill L.A.. ...
ISBN 978-3-642-32033-0. Timm S, Mielewczik M, Florian A, Frankenbach S, Dreissen A, Hocken N, Fernie AR, Walter A, Bauwe H (17 ... 49 (3): 393-7. doi:10.1104/pp.49.3.393. PMC 365972. PMID 16657968. Ma Y, Hartman MM, Moroney JV (January 2013). " ... Since the discovery of its activity in plants, it has been purified within human cells and implicated in 2,3-DPG regulation. ... 208 (2): 602-9. doi:10.1016/0003-9861(81)90549-x. PMID 6266352. Badwey JA (April 1977). "Phosphoglycolate phosphatase in human ...
Diphosphoglycerate may refer to: 1,3-Diphosphoglycerate 2,3-Diphosphoglycerate This set index page lists chemical compounds ...
  • Enzymes controlling 2,3-diphosphoglycerate in human erythrocytes, Fed. (ximicat.com)
  • The purification and properties of diphosphoglycerate mutase from human erythrocytes. (genome.jp)
  • On the Mechanisms of the Hypoxia Induced Increase of 2,3-Diphosphoglycerate in Erythrocytes. (springer.com)
  • Hypophosphataemia-induced depletion of 2,3-diphosphoglycerate in erythrocytes results in a left shift of the haemoglobin/oxygen dissociation curve, increasing haemoglobin affinity for oxygen and predisposing to local tissue hypoxia. (mja.com.au)
  • Astrup, P., P.M. Rörth, C.T. Thorshauge: Dependency on acid-base status of oxyhemoglobin dissociation and 2,3-diphosphoglycerate level in human erythrocytes. (springer.com)
  • Erythrocytes have intracellular hemoglobin, 2-3,diphosphoglycerate (2,3-DPG), and ATP, which all exert osmotic pressure across the semipermeable cell membrane. (medscape.com)
  • RBC concentrations of 2,3-DPG, venous blood gas pH, and oxygen partial pressure required for 50% hemoglobin saturation (P50) were measured at CRRT initiation and days 2, 4, and 7. (asnjournals.org)
  • at more elevated concentrations, blockade was nearly quantitative, affecting glycophorin and band 3 sites alike. (sanger.ac.uk)
  • P50 for oxygen (3.6 and 3.6 kPa) and 2,3-DPG concentrations (5.3 and 5.1 mikromol/ml erythrocyte) in shed mediastinal blood (1h and 6h postoperatively) were not significantly different compared to patient-blood. (biomedsearch.com)
  • Erythrocyte phosphofructokinase (PFK) activities and 2,3-diphosphoglycerate concentrations were decreased. (nih.gov)
  • A typical account goes like this [2]: "The membrane potential arises from the net actions of ion channels and ion pumps (such as the sodium-potassium ATPase) embedded in the membrane, which produce different concentrations of ions (and therefore electrical charge) on the intracellular and extracellular sides of the membrane. (i-sis.org.uk)
  • The organism has been reported to contain the trianionic cDPG (cyclic 2,3-diphosphoglycerate) and K + at concentrations of 1.1 and 3 M, respectively. (biochemsoctrans.org)
  • Initial red blood cell 2,3-diphosphoglycerate (2,3-DPG) concentrations were markedly decreased in ketoacidotic patients. (diabetesjournals.org)
  • Non-ketotic hyperosmolar coma patients revealed normal 2,3-DPG concentrations on admission, and a similar decline of plasma phosphorus occurred, as in ketoacidosis, during treatment. (diabetesjournals.org)
  • 2. The method according to claim 1 wherein the concentrations of free fatty acids in the plasma of the subject is due to a disorder associated with mitochondrial dysfunction. (freepatentsonline.com)
  • 3. The method according to claim 1 wherein the concentrations of free fatty acids in the plasma of the subject is due to impairment of muscle function. (freepatentsonline.com)
  • Decreased 2,3-DPG results from an inherited lack of the red blood cell enzymes 2,3-DPG mutase and 2,3-DPG phosphatase. (encyclopedia.com)
  • Decreased levels of 2,3-DPG are found in cases of erythrocytosis and nonspherocytic hemolytic anemia caused by 2,3-DPG mutase and 2,3-DPG phosphatase deficiencies. (encyclopedia.com)
  • Relationship of 2,3-diphosphoglycerate and 2,3-diphosphoglycerate mutase in various mammals. (biomedsearch.com)
  • Called also diphosphoglycerate mutase. (thefreedictionary.com)
  • It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (nih.gov)
  • 2, 3-diphosphoglycerate mutase: its demonstration by electrophoresis and the detection of a genetic variant. (arctichealth.org)
  • Phosphoglycerate mutase (2,3-diphosphoglycerate-independent). (expasy.org)
  • Reduced red cell 2,3-diphosphoglycerate and adenosine triphosphate, hypophosphatemia, and increased hemoglobin-oxygen affinity after cardiac surgery. (semanticscholar.org)
  • Role of Red Cell 2,3-Diphosphoglycerate in the Adaptation of Man to Altitude. (springer.com)
  • Austin, R.L., L.D. Stegink, C.V. Gisolfi, R.M. Lauer: The effect of exercise on red blood cell 2,3-diphosphoglycerate in children. (springer.com)
  • Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. (uniprot.org)
  • Biosynthesis of cyclic 2,3-diphosphoglycerate. (uniprot.org)
  • Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus. (uniprot.org)
  • The substitution affects one of the 2, 3-diphosphoglycerate binding sites, resulting in an increased affinity for oxygen, but both the haem-haem interaction and the alkaline Bohr effect are normal in the haemolysate. (nih.gov)
  • LICHTMAN MA, MILLER DR, COHEN J, WATERHOUSE C. Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate Concentration, and Increased Hemoglobin-Oxygen Affinity Caused by Hypophosphatemia. (annals.org)
  • This study sought to confirm that phosphate depletion during CRRT may decrease red blood cell (RBC) concentration of 2,3-diphosphoglycerate (2,3-DPG), a crucial allosteric effector of hemoglobin's (Hgb's) affinity for oxygen, thereby leading to impaired oxygen delivery to peripheral tissues. (asnjournals.org)
  • Therefore, 10 consecutive patients were studied to determine if reduced 2,3-diphosphoglycerate (DPG) and adenosine triphosphate (ATP) concentration and increased hemoglobin-oxygen affinity accompanied the fall in serum inorganic phosphate concentration. (semanticscholar.org)
  • A significant fall in 2,3-DPG and an increase in hemoglobin-oxygen affinity was present in red cells of patients studied on the first postoperative day. (semanticscholar.org)
  • In addition to reducing hemoglobin-O2 affinity, 2,3-diphosphoglycerate (DPG) is known to modulate the mechanical properties of the erythrocyte membrane. (sanger.ac.uk)
  • In studies of membrane-skeleton interactions, DPG was observed to inhibit the fast and slow phases of ankyrin binding to band 3 and to reduce both the number of ankyrin sites and affinity of ankyrin for each class of site. (sanger.ac.uk)
  • Bard E., Teasdale F. (1979) Red cell oxygen affinity hemoglobin type 2,3-difosfoglicerate and pH, a function of fetal development. (edu.pl)
  • Gibby O. M., Veale K. E. A., Hayes T. M., Jones J. G., Wardrop C. A. J. (1978) Oxygen availability from blood and the effect of phosphate replacement on erythrocyte 2,3-diphosphoglycerate and hemoglobin-oxygen affinity in diabetic ketoacidosis. (edu.pl)
  • Genetically based modifications of hemoglobin (Hb) function that increase blood-O 2 affinity are hallmarks of hypoxia adaptation in vertebrates. (biologists.org)
  • This combination of features compromises the acclimatization capacity of blood-O 2 affinity and has led to the hypothesis that felids have a restricted physiological niche breadth relative to other mammals. (biologists.org)
  • Given the low O 2 affinity and reduced regulatory capacity of feline Hbs, the extreme hypoxia tolerance of snow leopards must be attributable to compensatory modifications of other steps in the O 2 -transport pathway. (biologists.org)
  • As this positively charged cleft is accessible for DPG binding in the low-affinity T quaternary structure of the tetrameric (α 2 β 2 ) Hb but not in the high-affinity R structure, changes in red blood cell DPG levels alter Hb-O 2 affinity by shifting the T-R allosteric equilibrium of the Hb ( Weber, 2007 ). (biologists.org)
  • Although Hb-O 2 affinity is also allosterically regulated by chloride ions (Cl − ), the Cl − concentration does not change appreciably in red blood cells ( Nikinmaa, 1990 ). (biologists.org)
  • Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). (uniprot.org)
  • Inherited high erythropoietin levels Abnormal haemoglobin with the increased oxygen affinity Decreased level of metabolite (2,3 Diphosphoglycerate). (netdoctor.co.uk)
  • Increased affinity for oxygen in the blood caused by decreased production of 2,3-bisphosphoglyceric acid . (wikipedia.org)
  • We also investigated the effect of extracellular adenine nucleotides on red cell organic phosphate pattern and O2 affinity to test whether the inhibitory effect of normal or elevated PO2 on 2,3-DPG synthesis and the concomitant increase of ATP (and O2 half-saturation pressure) can be mimicked by these agents. (uni-regensburg.de)
  • We also found that extracellular ATP, which is rapidly degraded to AMP by red cell ectoenzymes, can alter the red cell phosphate pattern and O2 affinity, i.e., significantly increase red cell ATP, decrease red cell 2,3-DPG and O2 affinity, and thus mimic the effect of normoxia and hyperoxia. (uni-regensburg.de)
  • A marked reduction in red cell glucose utilization, lactate production, and 2,3-diphosphoglycerate and adenosine triphosphate concentration occurred in a patient with intractable diarrhea during a period of hypophosphatemia induced by parenteral nutrition with hypertonic glucose and protein hydrolysate. (annals.org)
  • HbS polymerizes only when deoxygenated, its oxygenation is influenced by a few factors, one key factor being the 2,3- diphosphoglycerate (2,3-DPG) concentration in the red blood cell. (clinicaltrials.gov)
  • In addition, increased 2,3-DPG concentration decreases intracellular red cell pH further promoting HbS polymerization. (clinicaltrials.gov)
  • The main objective of the work was to evaluate the influence of a six day supplementation with sodium phosphate on circulatory and pulmonary variables, the level of 2,3-diphosphoglycerate (2,3-DPG) and the concentration of inorganic phosphates in blood serum of elite off-road cyclists. (edu.pl)
  • The changes in the resting and post exercise concentration of 2,3-DPG were non significant, yet the supplementation procedure showed a tendency for increased level of this variable. (edu.pl)
  • In an attempt to estimate the influences of CO on the CO2 Bohr effect and the 2,3-diphosphoglycerate (DPG) effect linked to the reversible binding of O2 to the hemoglobin molecule (Hb), O2 dissociation curves of human blood in the presence of CO were investigated at 37 degrees C over a DPG concentration ranging from 2.2 to 4.3 mmol/(1RBC) and a pH range of 7.2 to 7.6. (elsevier.com)
  • This study measured the level of 2,3-diphophoglycerate and the factors affecting its concentration, as well as the position of the oxygen - hemoglobin dissociation curve in patients with end-stage liver disease . (bvsalud.org)
  • A 0.3 g/L increase in the 2,3-diphosphoglycerate concentration corresponded to a P50 increase in 1.2 mmHg with a rightward displacement of the oxygen - hemoglobin dissociation curve. (bvsalud.org)
  • The 2,3-diphosphoglycerate concentration showed a significant correlation with the PaO2, Ca-vO2, P50, and blood lactate level, but not with the hemodynamic parameters such as the cardiac index, oxygen delivery index, and pH . (bvsalud.org)
  • The oxygen delivery capacity of the blood to the tissues was calculated by use of the oxygen status algorithm (OSA 2.0) programme and measurement of the 2,3-diphosphoglycerate (2,3-DPG) concentration. (biomedsearch.com)
  • There were no significant changes of 2,3-DPG concentration in the patient-blood during cardiopulmonary bypass or after autotransfusion compared to preoperative values. (biomedsearch.com)
  • Blood, from a catheter in a superficial cubital vein, will also be taken at rest, at a precise time during the exercise and immediately after the exercise to measure potential of hydrogen, bicarbonates, haemoglobin concentration, hematocrit, erythrocyte 2,3-diphosphoglycerate, and other blood markers of metabolic and hormonal adaptations to exercise. (clinicaltrials.gov)
  • Time-dependent changes in the concentration of 2,3-diphosphoglycerate of normal human red cells show an initial lag phase, followed by a slow linear decrease. (unboundmedicine.com)
  • Pseudomonas species lack the 6-phosphofructokinase gene required for glycolysis, and glucose is converted to glyceraldehyde-3-phosphate (GAP) and pyruvate (Pyr) via the Entner-Doudoroff (ED) pathway. (asm.org)
  • These findings demonstrate that the decreased anabolism of glucose into UDPG and 1,3-β-glucan triggered by a defect in the Rim15p-mediated upregulation of PGM2 and UGP1 redirects the glucose flux into glycolysis. (asm.org)
  • This drop in intracellular CO 2 causes a rise in cellular pH which has a stimulating effect on glycolysis . (wikipedia.org)
  • Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase. (semanticscholar.org)
  • Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a key regulatory function in glucose oxidation by mediating fluxes through glycolysis or the pentose phosphate pathway (PPP) in an oxidative stress-dependent fashion. (bloodjournal.org)
  • Progressive increases in PPP/glycolysis ratios were determined via metabolic flux analysis after spiking 13 C 1,2,3 -glucose in erythrocyte concentrates stored in Additive Solution-3 under blood bank conditions for up to 42 days. (bloodjournal.org)
  • Influences of carbon monoxide on the binding of oxygen, carbon dioxide, proton and 2,3-diphosphoglycerate to human hemoglobin. (elsevier.com)
  • This phenomenon is seen because in respiratory alkalosis carbon dioxide (CO 2 ) decreases in the extracellular space, causing intracellular CO 2 to freely diffuse out of the cell. (wikipedia.org)
  • When more oxygen is required because of increased metabolism, such as in hyperthyroidism, more 2,3-DPG is produced. (encyclopedia.com)
  • Age-Related Defects in Erythrocyte 2,3-Diphosphoglycerate Metabolism i" by Yury G. Kaminsky, Prakash Reddy et al. (mst.edu)
  • Collectively, our data suggested that AD and NA patients are associated with chronic disturbance of 2,3-DPG metabolism in RBCs. (mst.edu)
  • Age-Related Defects in Erythrocyte 2,3-Diphosphoglycerate Metabolism in Dementia," Aging and Disease , vol. 4, no. 5, pp. 244-255, International Society on Aging and Disease, Oct 2013. (mst.edu)
  • Carbohydrate Metabolism and Its Disorders, vols 1 and 2, Academic Press. (ximicat.com)
  • First studied and purified within plants, phosphoglycolate phosphatase plays a major role in photorespiratory 2-phosphoglycolate metabolism, an essential pathway for photosynthesis in plants. (wikipedia.org)
  • Pseudomonas central carbon metabolism has been well studied during recent decades ( 1 - 3 ). (asm.org)
  • 3 - 5 With refeeding, there is a shift back to carbohydrate metabolism and an increase in insulin levels. (mja.com.au)
  • In addition, we have investigated the effect of carbamylation on the metabolism of 2,3-diphosphoglycerate and the intracellular pH in SS and AA red cells and have found that neither one is affected by this process. (unboundmedicine.com)
  • In contrast, the primary abnormality in DHSt is a change in the relative membrane permeability to K + . Efflux of K + is increased 2- to 4-fold and results in cation depletion, with decreased intracellular osmolality and water loss. (medscape.com)
  • The time-dependent depletion of adenosine-5' triphosphate in these red cells is similar in nature to that of 2,3-diphosphoglycerate. (unboundmedicine.com)
  • Cade R., Privette M., Lunne D. (1979) Effect of phosphate on 2,3-DPG, O2 tension and hematocrit in patients on chronic hemodialysis. (edu.pl)
  • Bureau , M. A. et al "Maternal Cigarette Smoking and Fetal Oxygen Transport: A Study of P50, 2,3-Diphosphoglycerate, Total Hemoglobin, Hematocrit, and Type F Hemoglobin in Fetal Blood. (aappublications.org)
  • [1] Hypophosphatemia occurs in about 2% of people within hospital and 70% of people in the intensive care unit (ICU). (wikipedia.org)
  • Hypophosphatemia decreases 2,3-diphosphoglycerate (2,3-DPG) causing a left shift in the oxyhemoglobin curve. (wikipedia.org)
  • If severe hypophosphatemia is present for longer than 2-3 days, serious complications can be seen, including rhabdomyolysis, respiratory failure, acute hemolytic anemia, and fatal arrhythmias. (medscape.com)
  • 11 Phosphate is found in phospholipids, nucleic acids, adenosine triphosphate and 2,3-diphosphoglycerate in red blood cells. (mja.com.au)
  • However, in circulating chicken embryonic RBCs, the enzyme is induced together with carbonic anhydrase (CAII) and 2,3-bisphosphoglycerate (2,3-BPG) by norepinephrine (NE) and adenosine, which are released by the embryo under hypoxic conditions. (uni-regensburg.de)
  • The p5n-I expression is induced (1) in definitive but not primitive RBCs by stimulation of beta-adrenergic/adenosine receptors, and (2) in definitive RBCs by hypoxic incubation of the chicken embryo. (uni-regensburg.de)
  • No adenosine triphosphate (ATP) or 2,3-diphosphoglycerate (DPG) remained in the blood stored in ACD alone. (dtic.mil)
  • When aged cells containing little 2,3-diphosphoglycerate were incubated in the presence of inosine and pyruvate, 2,3-diphosphoglycerate formation could be demonstrated. (pnas.org)
  • red cell 2 3 DPG level Can you superimpose on the graph the oxygen dissociation curve for foetal haemoglobin? (hendriksentuinbestrating.nl)
  • The oxyhaemoglobin dissociation curve (OHDC) and intraerythrocytic 2,3-diphosphoglycerate (2,3-DPG) play an important role in oxygen delivery, especially during shock. (meta.org)
  • The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. (genome.jp)
  • Depence of Oxyhemoglobin Dissociation and Intraery-Throcytic 2,3-DPG on Acid-Base Status of Blood. (springer.com)
  • The latter changes may indicate the diversion of glucose and more specifically 1,3-DPG into the RapoportLeubering pathway away from ATP generation at the phosphoglycerate kinase step and the utilization of plasma inorganic phosphate for 2,3-DPG resynthesis. (semanticscholar.org)
  • Phosphoglycolate, which is a potent inhibitor of phosphofructokinase and triosephosphate isomerase, must be quickly metabolized and transformed into a useful substrate, and phosphoglycolate phosphatase catalyzes the first step in the regeneration of 3-phosphoglycerate from 2-phosphoglycolate at the expense of energy in the form of ATP. (wikipedia.org)
  • In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. (genome.jp)
  • Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25. (semanticscholar.org)
  • Shortly after these molecule splits into 2 3-carbon molecules named phosphoglycerate (12 after all have split. (biology-online.org)
  • Another phosphate group is added to the phosphoglycerate by the dephosphorylation of 12 ATP (products are 12 diphosphoglycerate and 12 ADP. (biology-online.org)
  • These enzymes are needed to make 2,3-DPG. (encyclopedia.com)
  • The gene was localized downstream of gnd and zwf-2 , which encode enzymes involved in the pentose phosphate and Entner-Doudoroff pathways. (asm.org)
  • CHC clinically manifests with mild hemolytic anemia and is remarkable for an abnormality of the band 3 chloride-bicarbonate exchanger AE1. (medscape.com)
  • 2,3-DPG is an intermediate substrate in the glycolytic pathway, the only source of ATP production in red blood cells. (clinicaltrials.gov)
  • The 1.58 Mb genome of Ca. N. cavascurensis harbors an amo AXCB gene cluster encoding ammonia monooxygenase and genes for a 3-hydroxypropionate/4-hydroxybutyrate pathway for autotrophic carbon fixation, but also genes that indicate potential alternative energy metabolisms. (frontiersin.org)
  • Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an evolutionarily conserved enzyme that controls glucose flux through the canonical Embden-Meyerhof glycolytic pathway. (bloodjournal.org)
  • Among mammals, felid Hbs are unusual in that they have low intrinsic O 2 affinities and reduced sensitivities to the allosteric cofactor 2,3-diphosphoglycerate (DPG). (biologists.org)
  • J Am Osteopath Assoc 1972;72(2):172. (jaoa.org)
  • Increased intracellular 2,3-DPG decreases oxygen binding and stabilizes the deoxygenated form (T form) of hemoglobin. (clinicaltrials.gov)
  • Bicarbonate, unlike CO 2 , has poor diffusion across the cellular membrane and therefore there is little change in intracellular pH. (wikipedia.org)
  • Intracellular calcium, as measured by a modification of Harrison and Long's procedure, is increased by 35 and 55% above control levels following exposure to shear stresses of 1000 and 1300 dynes/cm('2) for two minutes, and is associated with decreasing deformability. (rice.edu)
  • No significant changes are found for intracellular magnesium, 2,3-diphosphoglycerate or mean cell volume. (rice.edu)
  • 2 In addition, tissue anabolism increases cellular demand for phosphate, glucose, potassium and water. (mja.com.au)
  • Reversible oxidation of GAPDH promotes metabolic reprogramming of stored RBCs, as gleaned through tracing with 13 C 1,2,3 -glucose. (bloodjournal.org)
  • Note that it takes 2 glyceraldehyde 3-P molecules for the cell to make a fructose and later a glucose (both are isomers of a hexose. (biology-online.org)
  • Reduced PK activity leads to accumulation of the upstream enzyme substrates, including 2,3- DPG, that favours polymerization of deoxy-HbS. (clinicaltrials.gov)
  • Phosphoglycolate phosphatase(PGP), also commonly referred to as phosphoglycolate hydrolase, 2-phosphoglycolate phosphatase, P-glycolate phosphatase, and phosphoglycollate phosphatase, is an enzyme responsible for catalyzing the conversion of 2-phosphoglycolate into glycolate and phosphate. (wikipedia.org)
  • 30 years, these reactions have been considered the responsibility of a single enzyme, the 2,3-BPG synthase/2-phosphatase (BPGM). (semanticscholar.org)
  • In the laboratory, a person's serum is mixed with a substance that will react with 2,3-DPG. (encyclopedia.com)
  • and from that measurement, the amount of 2,3-DPG in the person's serum is determined. (encyclopedia.com)
  • The reduction in serum inorganic phosphorous followed the reduction in red cell 2,3-DPG and correlated with the reduction in ATP. (semanticscholar.org)
  • Should We Monitor ScVO(2) in Critically Ill Patients? (meta.org)
  • 2,3-DPG levels are important in large blood transfusions, because stored blood quickly loses 2,3-DPG and its ability to deliver oxygen. (encyclopedia.com)
  • Exercise increases the body's need for oxygen and could cause a temporary increase in levels of 2,3-DPG. (encyclopedia.com)
  • Increased levels of 2,3-DPG are found in conditions in which the body needs more oxygen, such as anemia, obstructive lung disease, cystic fibrosis , congenital heart disease , and hyperthyroidism. (encyclopedia.com)
  • The data demonstrated that the minimal levels of 2,3-DPG in the adult sheep are likely due to the very low levels of DPGM. (biomedsearch.com)
  • Also these findings show that the increases in 2,3-DPG levels, found in the newborn sheep during the 1st week of life, in adult rabbit and guinea pig when compared with their fetuses, are not due to an increase in levels of the DPGM. (biomedsearch.com)
  • 2,3-DPG levels after 2 days of CRRT were not significantly lower than those in the reference group on day 2. (asnjournals.org)
  • A reduction in red cell ATP was also present and persisted for 5 days during which time red cell 2,3-DPG returned to levels which were in excess of preoperative values. (semanticscholar.org)
  • 2,3-diphosphoglycerate (2,3-DPG) levels were significantly decreased in AD and NA patients. (mst.edu)
  • [3] In cases where patients have low levels of hemoglobin due to iron deficiency, but are cardiovascularly stable, parenteral iron is a preferred option based on both efficacy and safety. (wikipedia.org)
  • At lower PO2 levels, your red blood cells make more of a substance called 2,3-diphosphoglycerate. (livestrong.com)
  • 2,3-DPG levels remained unaffected by phosphate therapy. (diabetesjournals.org)
  • The extra oxygen is released by increased levels of inorganic phosphates in the red blood cells, such as 2,3-diphosphoglycerate (2,3-DPG). (britannica.com)
  • Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. (curehunter.com)
  • The recovery of 2,3-DPG upon institution of therapy was accelerated when phosphate replacement infusions were given. (diabetesjournals.org)
  • Since the discovery of its activity in plants, it has been purified within human cells and implicated in 2,3-DPG regulation. (wikipedia.org)
  • 672. Arnone A,, X-ray diffraction study of binding of 2,3-diphosphoglycerate to human deoxyhaemoglobin. (ximicat.com)
  • Ayres, P.J., O. Garrod, S.A.S. Tait, J.F. Tait, G. Walker, W.H. Pearlman: The use of (16 -3 H) aldosterone in studies on human peripheral blood. (springer.com)
  • 1987) Modulation of erythrocyte membrane mechanical stability by 2,3‐diphosphoglycerate in the neonatal poikilocytosis/elliptocytosis syndrome. (els.net)
  • The reaction between diphosphoglycerate and hemoglobin, Fed. (ximicat.com)
  • There was a positive correlation between P50 std and 2,3-DPG, arterial blood pH, haemoglobin and cardiac index, as well as between 2,3-DPG and arterial blood pH. (meta.org)
  • Effect of inosine supplementation on 3-mile treadmill run performance and VO2 peak. (webmd.com)
  • Hemoglobin, the protein in the blood that carries oxygen, uses 2,3-DPG to control how much oxygen is released once the blood gets out into the tissues. (encyclopedia.com)
  • TORQ recovery represents this 3:1 blend of Multiple Transportable Carbohydrates and high quality Whey Protein.It is generally accepted that consuming Multiple-Transportable Carbohydrates and Whey Protein at a 3:1 ratio immediately after exercise will speed up glycogen synthesis (see fully referenced information below). (torqfitness.co.uk)
  • tissues and the content of 2,3-diphosphoglycerate (2,3-DPG) in red cells. (britannica.com)
  • The more 2,3-DPG in the cell, the more oxygen is delivered to body tissues. (encyclopedia.com)
  • Without 2,3-DPG to control the movement of oxygen to its tissues, the body responds by making more red blood cells, a condition called erythrocytosis. (encyclopedia.com)
  • It is believed that an increase in the level of erythrocyte 2,3-diphosphoglycerate is an important compensatory mechanism that allows satisfactory tissue oxygenation in hypoxic patients . (bvsalud.org)
  • Ketoacidosis may develop in patients with type 2 diabetes when severe stress such as sepsis or trauma is present. (health.am)
  • DKA has long been considered a key clinical feature of type 1 diabetes (T1D), but in contrast to popular belief, DKA is more common in patients with type 2 diabetes (T2D). (renalandurologynews.com)
  • however, patients with type 2 diabetes are also at risk during the catabolic stress of acute illness. (diabetesjournals.org)
  • Diphosphoglycerate may refer to: 1,3-Diphosphoglycerate 2,3-Diphosphoglycerate This set index page lists chemical compounds articles associated with the same name. (wikipedia.org)
  • When sequential recordings of freshly collected blood were made, 2,3-diphosphoglycerate was observed to decrease in association with a concomitant increase in inorganic orthophosphate. (pnas.org)
  • RRR1/ORC2 is an essential gene, but the rrr1-316 allele, which is viable, is defective in the replication of nuclear DNA and the maintenance of the 2-microns episomal DNA. (sanger.ac.uk)
  • The pathogen causes coronavirus-19 disease (COVID-19), which spread rapidly, reaching the pandemic level on March 11, 2020 2 . (nature.com)
  • 2 , 3 , 10 This is often associated with hypokalaemia, hypomagnesaemia, sodium and fluid retention, thiamine deficiency and hyperglycaemia. (mja.com.au)
  • [3] He used sodium citrate as the anticoagulant, and the blood was extracted from punctures in the vein, and was stored in bottles at British and American Casualty Clearing Stations along the Front. (wikipedia.org)
  • However, that this effect is not seen in metabolic alkalosis , for in such cases the cause of the alkalosis is increased bicarbonate rather than decreased CO 2 . (wikipedia.org)
  • His con- posium of the XXV International Congress tributions over 50 years covered four main of Physiology on "C0 and Metabolic eras in the development of physiology: 2 Regulations" are dedicated to Wallace muscle, electrolyte, respiratory, and hyper- Osgood Fenn. (springer.com)
  • Previous studies documented metabolic reprogramming in stored red blood cells (RBCs) and oxidation of GAPDH at functional residues upon exposure to pro-oxidants diamide and H 2 O 2 . (bloodjournal.org)
  • Mortality rates are 2-5% for DKA and 15% for HHS, and mortality is usually a consequence of the underlying precipitating cause(s) rather than a result of the metabolic changes of hyperglycemia. (diabetesjournals.org)
  • D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus. (ximicat.com)
  • We now have 12 diphosphoglycerate molecyles which are reduced by the reduction of 12 NADPH, the products are 12 NADP and 12 glyceraldehyde 3-P. At this point, 2 glyceraldehyde 3-P molecule are outputted while the other 10 continue cycling through. (biology-online.org)
  • A series of reactions uses the energy from 6ATP to rearrange the atoms of the 10 glyceraldehyde 3-P to forming another 6 ribulosebisphosphate molecules to cycle through again. (biology-online.org)
  • 5. The method according to claim 4 wherein the diabetes is type 2 diabetes. (freepatentsonline.com)
  • 3 Many of these adult patients with DKA were classified as having type 2 diabetes because 29% of patients were obese, had measurable insulin secretion, and had a low prevalence of autoimmune markers of β-cell destruction. (diabetesjournals.org)
  • Regulation of linkages between the erythrocyte membrane and its skeleton by 2,3-diphosphoglycerate. (sanger.ac.uk)
  • By fluorescence spectroscopy and differential scanning calorimetry, we demonstrate that DPG binds the cytoplasmic domain of erythrocyte membrane band 3 in two stages characterized by apparent KD values of approximately approximately 2 and 12 mM. (sanger.ac.uk)
  • Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. (semanticscholar.org)
  • 2,3-DPG testing is done to help investigate both a deficiency in red blood cells (anemia) and an unexplained increase of red blood cells, called erythrocytosis. (encyclopedia.com)
  • End-stage liver disease is associated with an increase in the level of the erythrocyte 2,3-diphosphoglycerate and P50. (bvsalud.org)
  • An increase in the 2,3-diphosphoglycerate level correlates well with the oxygenation parameters , rather than with the hemodynamic parameters . (bvsalud.org)
  • Furthermore, the impairment of UDPG or 1,3-β-glucan synthesis contributed to an increase in the fermentation rate. (asm.org)
  • An increase in 2,3-DPG will improve the availability of oxygen to working muscles during exercise. (hammernutrition.com)
  • Hypoxia is the alleged stimulus for initiation of increase of carbonic anhydrase II (CAII) and 2,3-diphosphoglycerate (2,3-DPG) synthesis of red blood cells from late chick embryos. (uni-regensburg.de)
  • Knockdown of FOXM1 resulted in a 2-fold increase in erythroid cells compared to myeloid cells. (stanford.edu)
  • On the other hand, there existed no correlation between P50 std or 2,3-DPG, and Pao2, Paco2 and phosphoremia. (meta.org)