2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)Diphosphoglyceric AcidsBisphosphoglycerate Mutase: An enzyme that catalyzes the transfer of phosphate from C-3 of 1,3-diphosphoglycerate to C-2 of 3-phosphoglycerate, forming 2,3-diphosphoglycerate. EC 5.4.2.4.Hemoglobin A: Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.Hemoglobins, Abnormal: Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Oxyhemoglobins: A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Phytic Acid: Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.Glyceric AcidsOxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Phosphoglycerate Mutase: An enzyme that catalyzes the conversion of 2-phospho-D-glycerate to 3-phospho-D-glycerate. EC 5.4.2.1.Methanobacteriales: An order of anaerobic, coccoid to rod-shaped methanogens, in the kingdom EURYARCHAEOTA. They are nonmotile, do not catabolize carbohydrates, proteinaceous material, or organic compounds other than formate or carbon monoxide, and are widely distributed in nature.Glycerophosphates: Any salt or ester of glycerophosphoric acid.Hemoglobin, Sickle: An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.Phosphoglycerate Kinase: An enzyme catalyzing the transfer of a phosphate group from 3-phospho-D-glycerate in the presence of ATP to yield 3-phospho-D-glyceroyl phosphate and ADP. EC 2.7.2.3.CarboxyhemoglobinMethemoglobinPolycythemia: An increase in the total red cell mass of the blood. (Dorland, 27th ed)Hemoglobinometry: Measurement of hemoglobin concentration in blood.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Partial Pressure: The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Phosphorus-Oxygen Lyases: Enzymes that catalyze the cleavage of a phosphorus-oxygen bond by means other than hydrolysis or oxidation. EC 4.6.Euryarchaeota: A phylum of ARCHAEA comprising at least seven classes: Methanobacteria, Methanococci, Halobacteria (extreme halophiles), Archaeoglobi (sulfate-reducing species), Methanopyri, and the thermophiles: Thermoplasmata, and Thermococci.Erythrocyte Aging: The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.Phosphotransferases: A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.Blood Protein Electrophoresis: Electrophoresis applied to BLOOD PROTEINS.Blood Preservation: The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Erythrocytes, Abnormal: Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.Kinetics: The rate dynamics in chemical or physical systems.Pyruvate Kinase: ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.Erythrocyte Deformability: Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.Phosphates: Inorganic salts of phosphoric acid.Inosine: A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)Mathematics: The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Glyceraldehyde-3-Phosphate Dehydrogenases: Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceraldehyde-3-phosphate-dehydrogenase exist including phosphorylating and non-phosphorylating varieties and ones that transfer hydrogen to NADP and ones that transfer hydrogen to NAD.Fetal Hemoglobin: The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.Allosteric Site: A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Phosphofructokinase-1: An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.PyruvatesHemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.Glycolysis: A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
*  2,3-Bisphosphoglyceric acid
2,3-BPG is formed from 1,3-BPG by the enzyme BPG mutase. It can then be broken down by 2,3-BPG phosphatase to form 3- ... 2,3-BPG is part of a feedback loop that can help prevent tissue hypoxia in conditions where it is most likely to occur. ... When 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier. It ... It's important to highlight that the behaviour of myoglobin doesn't work in the same way, as 2,3-BPG has no effect on it. In ...
*  Blood doping
The presence of 2,3-diphosphoglycerate within erythrocytes maintains the normal affinity of hemoglobin for oxygen. HBOCs do not ... As a significant amount of iron is removed by each autologous transfusion, an adequate time for recovery of not less than 3 ... of the Hypoxia inducing transcription factors HIF-1α and HIF-2α, and thus stabilizes these protein complexes. Under normal O2 ...
*  Aldolase A deficiency
105 (2): 105-6. doi:10.1182/blood-2004-09-3558. PMID 15632214. Miwa S, Fujii H, Tani K, Takahashi K, Takegawa S, Fujinami N, ... 103 (6): 2401-3. doi:10.1182/blood-2003-09-3160. PMID 14615364. Esposito G, Vitgliano L, Cevenini A, Amelio T, Zagari A, ... 335 (16): 1242-3. doi:10.1056/NEJM199610173351618. PMID 8999331. Takasaki Y, Takahashi I, Mukai T, Hori K (1990). "Human ... Glycolysis also produces 2,3-diphosphoglycerate required to modulate hemoglobin's affinity for oxygen (2,3-Bisphosphoglycerate ...
*  Luebering-Rapoport pathway
2,3-BPG, the reaction product of the Luebering-Rapoport pathway was first described and isolated in 1925 by the Austrian ... R. Juel: 2,3-Diphosphoglycerate: its role in health and disease. In: CRC Critical Reviews in Clinical Laboratory Sciences. 10(2 ... The concentration of 2,3-BPG varies inversely with the pH, since it is inhibitory to catalytic action of ... 2,3-bisphosphoglycerate, the most concentrated organophosphate in the erythrocyte, forms 3-PG by the action of ...
*  Blood bank
2, p. 12. Atkinson, M. P.; Fontaine, M. J.; Goodnough, L. T.; Wein, L. M. (2012). "A novel allocation strategy for blood ... 30 (2): 475-87. doi:10.1016/j.cll.2010.02.002. PMID 20513565. "Archived copy" (PDF). Archived from the original (PDF) on 2013- ... The blood was stored in a sterile glass enclosed under pressure at 2 °C. During 30 months of work, the Transfusion Service of ... Platelets are typically pooled before transfusion and have a shelf life of 5 to 7 days, or 3 days once the facility that ...
*  Phosphoglycolate phosphatase
49 (3): 393-397. doi:10.1104/pp.49.3.393. ISSN 0032-0889. PMC 365972 . PMID 16657968. Ma, Yunbing; Hartman, Megan M.; Moroney, ... Since the discovery of its activity in plants, it has been purified within human cells and implicated in 2,3-DPG regulation. ... 42 (2): 143-151. doi:10.1111/j.1469-1809.1978.tb00644.x. ISSN 1469-1809. Molecular and Cellular Biology portal. ... 208 (2): 602-609. doi:10.1016/0003-9861(81)90549-x. ISSN 0003-9861. PMID 6266352. Badwey, J. A. (1977-04-10). "Phosphoglycolate ...
*  Blood transfusion
30 (2): 475-87. doi:10.1016/j.cll.2010.02.002. PMID 20513565. Cata, JP; Wang, H; Gottumukkala, V; Reuben, J; Sessler, DI (May ... 85 (2): 117-22. doi:10.1002/ajh.21599. PMID 20052749. Heaton, A; Keegan, T; Holme, S (1989). "In vivo regeneration of red cell ... In the immediate spin method, two drops of patient serum are tested against a drop of 3-5% suspension of donor cells in a test ... ISBN 3-540-13255-4. Laura Landro (2007-01-10). "New rules may shrink ranks of blood donors". Wall Street Journal. WALD, MATTHEW ...
*  Phosphoglycerate mutase
227 (3): 595-607. doi:10.1016/0005-2744(71)90010-6. PMID 4328052. Wang, Y; Wei, Z; Liu, L; Cheng, Z; Lin, Y; Ji, F; Gong, W (17 ... 7 (3): 1115-21. doi:10.1021/bi00843a032. PMID 5690561. Salameh J, Goyal N, Choudry R, Camelo-Piragua S, Chong PS (July 2012). " ... 26 (3): 393-9. PMC 1762627 . PMID 4827367. Song, L; Xu, Z; Yu, X (August 2007). "Molecular cloning and characterization of a ... 2,3-bisphosphoglycerate is required a cofactor for dPGM. In contrast, the iPGM class is independent of 2,3-bisphosphoglycerate ...
*  University of Virginia School of Medicine
and was ranked in 2016 by U.S. News and World Report as one of the top 2-3% of cancer specialty centers nationwide. The Carter ... 1935 - 1967 - Alfred Chanutin, Ph.D., professor and chair of biochemistry, discovered the role of red blood cell 2,3- ... diphosphoglycerate (2,3-DPG) in oxygen transfer from hemoglobin. This finding had enormous impact on the preservation of blood ... integrated curriculum that allows medical students to spend more time in the clinic by condensing the first 2 years of classes ...
*  List of MeSH codes (D09)
... glyceraldehyde 3-phosphate MeSH D09.698.211.500 --- chitosan MeSH D09.698.350.500 --- inulin MeSH D09.698.360.041 --- agar MeSH ... 3-o-methylglucose MeSH D09.408.514.700 --- methylmannosides MeSH D09.408.620.569 --- nucleoside diphosphate sugars MeSH D09.408 ... 2,3-diphosphoglycerate MeSH D09.811.522.050 --- acetylmuramyl-alanyl-isoglutamine MeSH D09.811.589.668 --- sialic acids MeSH ... 3-o-methylglucose MeSH D09.408.348.700 --- picrotoxin MeSH D09.408.348.800 --- teniposide MeSH D09.408.348.820 --- ...
*  List of MeSH codes (D02)
... vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455.849.291.850 --- taxoids MeSH D02.455.849.291.850.777 ... 5-amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D02.640.600.290 --- fanft MeSH D02.640.600.308 --- furagin MeSH ... 3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ... 2,3-diketogulonic acid MeSH D02.241.081.844.300 --- glucaric acid MeSH D02.241.081.844.322 --- gluconates MeSH D02.241.081.844. ...
*  DPG
2,3-diphosphoglycerate), involved in hemoglobin-oxygen binding Dihydroxyphenylglycine, an amino acid Digital pair gain, a ...
*  Ecophysiology
66 (2): 214. doi:10.1111/j.1365-2494.2010.00778.x. Lincoln Taiz and Eduardo Zeiger, A Companion to Plant Physiology Stoll, M.; ... 13 (3): 240. doi:10.1016/j.pbi.2010.04.008. Lobell, D. B.; Schlenker, W.; Costa-Roberts, J. (2011). "Climate Trends and Global ... ISBN 978-3-540-20833-4. Retrieved 16 April 2013. Farrell, A. D.; Gilliland, T. J. (2011). "Yield and quality of forage maize ... ISBN 3-540-43516-6. McNab, B. K. (2002). The physiological ecology of vertebrates: a view from energetics. Ithaca and London: ...
*  Refeeding syndrome
3 (12): 943-952. doi:10.1016/S2213-2600(15)00418-X. ISSN 2213-2619. PMID 26597128. Webb GJ, Smith K, Thursby-Pelham F, Smith T ... 10 (2): 69-76. PMID 22041604. "Nutrition support in adults: oral nutrition support, enteral tube feeding and parenteral ... Formation of phosphorylated carbohydrate compounds in the liver and skeletal muscle depletes intracellular ATP and 2,3- ... diphosphoglycerate in red blood cells, leading to cellular dysfunction and inadequate oxygen delivery to the body's organs. ...
*  Bisphosphoglycerate phosphatase
... diphosphoglycerate phosphatase, 2,3-diphosphoglyceric acid phosphatase, 2,3-bisphosphoglycerate phosphatase, and glycerate-2,3- ... 233 (2): 350-4. PMID 13563500. RAPOPORT S, LUEBERING J (1951). "Glycerate-2,3-diphosphatase". J. Biol. Chem. 189 (2): 683-94. ... The systematic name of this enzyme class is 2,3-bisphospho-D-glycerate 2-phosphohydrolase. Other names in common use include 2, ... In enzymology, a bisphosphoglycerate phosphatase (EC 3.1.3.13) is an enzyme that catalyzes the chemical reaction 2,3-bisphospho ...
*  3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase
Other names in common use include diphosphoglycerate-polyphosphate phosphotransferase, and 1,3-diphosphoglycerate-polyphosphate ... 36 (2): 356-359. PMID 5557827. Kulaev, I.S.; Bobyk, M.A.; Nikolaev, N.N.; Sergeev, N.S.; Uryson, S.O. (1971). "Polyphosphate ... In enzymology, a 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase (EC 2.7.4.17) is an enzyme that catalyzes the ... Kulaev I.S.; Bobyk M.A. (1971). "Detection of a new enzyme in Neurospora crassa - 1,3-diphosphoglycerate: ...
*  GAPDHS
22 (3): 464-70. PMID 11330647. Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S ( ... 8 (3): 350-7. PMID 4349855. Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of ... 6 (2): 127-36. doi:10.1093/molehr/6.2.127. PMID 10655454. Bone W, Jones AR, Morin C, Nieschlag E, Cooper TG (2001). " ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Goodwin LO, Karabinus DS, Pergolizzi RG, Benoff S (Feb 2000 ...
*  List of diseases (D)
... syndrome Dionisi-Vici-Sabetta-Gambarara syndrome Diphallia Diphallus rachischisis imperforate anus Diphosphoglycerate mutase ... nephrogenic type 2 Diabetes insipidus, nephrogenic type 3 Diabetes insipidus, nephrogenic, dominant type Diabetes insipidus, ... congenital type 2 Dyserythropoietic anemia, congenital type 3 Dysferlinopathy Dysfibrinogenemia, familial Dysfibrinogenemia, ... nephrogenic, recessive type Diabetes mellitus Diabetes mellitus type 1 Diabetes mellitus type 2 Diabetes persistent mullerian ...
*  Oxygen-hemoglobin dissociation curve
High levels of 2,3-BPG shift the curve to the right (as in childhood), while low levels of 2,3-BPG cause a leftward shift, seen ... As a result, 2,3-BPG binds more strongly to adult hemoglobin, causing HbA to release more oxygen for uptake by the fetus, whose ... Automated analyzer 2,3-DPG is an abbreviation of 2,3-DiPhosphoGlyceric acid, an obsolete name for 2,3-BPG Ahern, Kevin; ... The production of 2,3-BPG is likely an important adaptive mechanism, because the production increases for several conditions in ...
*  Methylotroph
First, 2 molecules of formaldehyde are added to 2 molecules of the amino acid glycine. This produces two molecules of the amino ... Then these 3 molecules of DHA are phosphorylated to DHAP by triokinase. Like the other cycles, 3 C 3 {\displaystyle {{\ce {C3 ... The other 2 molecules are used to regenerate xylulose 5-phosphate. As key players in the carbon cycle, methylotrophs work to ... 22 (2-3): 307-319. doi:10.1007/s00775-016-1419-y. ISSN 0949-8257. Hanson, R. S.; Hanson, T. E. (1996-06-01). "Methanotrophic ...
*  Samuel Mitja Rapoport
9-19 Rapoport, S. and J. Luebering: An Optical Study Of Diphosphoglycerate Mutase (From the Children's Hospital Research ... 3/2004 Goldenberg, H. : Nachruf Univ.-Prof. Dr. Samuel Mitja Rapoport (1912-2004) Newsletter vom 20.07.2004 Gesammelt vom ... 1997; 3: 1-55 (Heft 9) Marxismus, Exil und jüdische Identität. Der Biochemiker Samuel Mitja Rapoport. Jüdisches Echo 49 ( ... Thus the survivability of the bottled blood could be extended from 1 to 3 weeks. In 1948, together with two other American ...
*  Acylphosphatase
224 (2): 427-40. doi:10.1016/0022-2836(92)91005-A. PMID 1313885. Stefani M, Taddei N, Ramponi G (February 1997). "Insights into ... 53 (2): 141-51. doi:10.1007/PL00000585. PMID 9118002. Rational stabilization of enzymes by computational redesign of surface ... Other names in common use include acetylphosphatase, 1,3-diphosphoglycerate phosphatase, acetic phosphatase, Ho 1-3, and GP 1-3 ... This enzyme participates in 3 metabolic pathways: glycolysis / gluconeogenesis pyruvate metabolism, and benzoate degradation ...
The main objective of the work was to evaluate the influence of a six day supplementation with sodium phosphate on circulatory and pulmonary variables, the level of 2,3-diphosphoglycerate (2,3-DPG) and the concentration of inorganic phosphates in blood serum of elite off-road cyclists. The research material included 19 cyclists which were randomly divided into a experimental group, supplemented with sodium phosphate and a control group receiving a placebo The subjects in the experimental group ingested sodium diphosphate in a dose of 50mg/kg of fat free mass per day. The supplement was ingested in even doses, four times per day. The control group received 4g of glucose in gelatin capsules (500mg), which were also divided into 4 even portions. During the experiment a significant (p,0.05) increase in maximal oxygen uptake was observed (VO2max), maximal minute ventilation (VEmax), as well as oxygen pulse (O2/HR). Also a significant decrease in resting and maximal exercise heart rate occurred. ...
2,3-Bisphosphoglycerate mutase (2,3-BPGM), an erythroid-expressed enzyme, synthesises 2,3-bisphosphoglycerate (2,3-BPG), the allosteric modulator of haemoglobin. This ligand has a higher affinity for adult haemoglobin than for fetal haemoglobin and differential binding of it facilitates transfer of oxygen between adult and fetal blood by lowering the affinity of adult haemoglobin for oxygen. This paper reports the discovery that 2,3-BPGM is synthesised in non-erythroid cells of the human placenta. Western blot analysis of placental extracts revealed high levels of 2,3-BPGM in the human placenta. Immunohistochemical staining and in situ hybridisation experiments indicated that abundant 2,3-BPGM is present in the syncytiotrophoblast layer of the placental villi at the feto-maternal interface. A cytochemical staining technique showed that the placental 2,3-BPGM is active, indicating that 2,3-BPG is synthesised in the outermost cells of the placenta. These observations demonstrate an unexpected and abundant
Serum inorganic phosphorous was decreased significantly on the third postoperative day following cardiac surgery in 18 patients initially studied. Reduced plasma inorganic phosphate has been shown to cause a reduced concentration of red cell organic phosphates, an important determinant of hemoglobin-oxygen affinity. Therefore, 10 consecutive patients were studied to determine if reduced 2,3-diphosphoglycerate (DPG) and adenosine triphosphate (ATP) concentration and increased hemoglobin-oxygen affinity accompanied the fall in serum inorganic phosphate concentration. A significant fall in 2,3-DPG and an increase in hemoglobin-oxygen affinity was present in red cells of patients studied on the first postoperative day. A reduction in red cell ATP was also present and persisted for 5 days during which time red cell 2,3-DPG returned to levels which were in excess of preoperative values. The reduction in serum inorganic phosphorous followed the reduction in red cell 2,3-DPG and correlated with the ...
2;3-Diphosphoglycerate/*analysis, Adenosine Triphosphate/*analysis, Biological Markers/analysis, Blood Preservation/*standards, Erythrocyte Aging, Erythrocytes/*chemistry, Hemolysis, Humans, Observer Variation, Plateletpheresis ...
Moriyama R, Lombardo CR, Workman RF and Low PS. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393.. In addition to reducing hemoglobin-O2 affinity, 2,3-diphosphoglycerate (DPG) is known to modulate the mechanical properties of the erythrocyte membrane. By fluorescence spectroscopy and differential scanning calorimetry, we demonstrate that DPG binds the cytoplasmic domain of erythrocyte membrane band 3 in two stages characterized by apparent KD values of approximately approximately 2 and 12 mM. DPG was also shown to perturb the stability of ankyrin, protein 4.1, and protein 4.2 in situ and to directly bind to protein 4.1. In studies of membrane-skeleton interactions, DPG was observed to inhibit the fast and slow phases of ankyrin binding to band 3 and to reduce both the number of ankyrin sites and affinity of ankyrin for each class of site. The inhibition was biphasic, similar to the band 3-DPG binding isotherm; however, at physiological DPG concentrations a ...
Coordenadas: 46° 23 46" N 112° 43 58" O Deer Lodge é uma cidade localizada no estado americano de Montana, no Condado de Powell, do qual é sede. Segundo o censo americano de 2000, a sua população era de 3421 habitantes. Em 2006, foi estimada uma população de 3311, um decréscimo de 110 (-3.2%). De acordo com o United States Census Bureau tem uma área de 3,7 km², dos quais 3,7 km² cobertos por terra e 0,0 km² cobertos por água. Deer Lodge localiza-se a aproximadamente 1379 m acima do nível do mar. O diagrama seguinte representa as localidades num raio de 36 km ao redor de Deer Lodge. Deer Lodge Condado de Anaconda-Deer Lodge (36 km) Avon (25 km) Elliston (29 km) Garrison (17 km) U.S. Census Bureau. Census 2000 Summary File 1 U.S. Census Bureau. Estimativa da população (julho de 2006) U.S. Board on Geographic Names. Topical Gazetteers Populated Places. Gráficos do banco de dados de altitudes dos Estados Unidos da América Estatísticas, mapas e outras informações sobre ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
The Winnipeg Regional Health Authoritys Deer Lodge Centre is a progressive 431 bed long-term care, geriatric rehabilitation and chronic care facility located in Winnipeg, Manitoba. Several years ago, Deer Lodge staff looked at their falls statistics and their numbers told them that they could do better. They developed policies, protocols and algorithms to address falls risk and implemented a screening process for everyone admitted to the facility. Their fall rates went down close to 30 per cent over three years, but when they looked at the national standards they found there was still room for improvement. In September 2011, Deer Lodge Centre joined the Safer Healthcare Now! Falls Facilitated Learning Series, a six-month virtual program designed to assist organizations working on reducing falls and injury from falls.. "We are using the Falls Facilitated Learning Series to take a look at hourly rounding," says Daryl Dyck, Clinical Nurse Specialist at Deer Lodge Centre. "On one unit we did a ...
Definition of Phosphoglyceromutase with photos and pictures, translations, sample usage, and additional links for more information.
Deer Lodge è una città degli Stati Uniti dAmerica situata in Montana, nella contea di Powell. Altri progetti Wikimedia Commons Wikimedia Commons contiene immagini o altri file su Deer Lodge (EN) Deer Lodge, in City-data.com, Advameg Inc ...
The chief characteristics of the blood of the turtle Pseudemys concinna, considered as a system for the transport of oxygen and carbon dioxide, are its low corpuscular content (10 to 22 per cent by volume) and its high concentration of base bound as bicarbonate.. These characteristics account fully for the shape and position of the carbon dioxide dissociation curve, the effect of oxygenation and reduction of the hemoglobin upon the carbon dioxide-combining power of the blood, and the distribution of carbon dioxide between the corpuscles and plasma.. The oxygen-combining capacity of the turtle corpuscles does not differ from that of an equal volume of human erythrocytes. The oxygen dissociation curve is similar to that of mammalian blood and is affected in like manner by the quantity of carbon dioxide present. Its exact shape and position depend in part upon the number of corpuscles in the blood; in part its characteristics cannot be attributed to known chemical factors.. ...
1. Oxygen-binding, plasma and intra-erythrocytic pH, and haemoglobin, 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years.. 2. P50 (oxygen tension at 50% oxygen saturation) expressed at plasma pH 7·40 and Pco2 5·33 kPa showed a positive correlation with age.. 3. This correlation of P50 with age was closer when P50 was expressed at a constant intra-erythrocytic pH 7·20. On average P50 at intra-erythrocytic pH 7·20 increased from 3·59 kPa at 20 years to 3·96 kPa at 90 years of age.. 4. 2,3-Diphosphoglycerate, inorganic phosphate, haemoglobin and mean corpuscular haemoglobin concentrations did not correlate with P50 or with age.. ...
Dihydroxyacetone: A ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent.
The oxygen dissociation curve is s shaped which means that increasing ventilation to units with high VQ ratios cannot compensate for the shunt caused by low VQ ...
Mon Dec 21 00:00:00 MST 2009. A fur handling workshop is scheduled for Saturday, Jan. 9, 2010 in Deer Lodge. The all-day workshop, sponsored by the Montana Trappers Association, will offer information and demonstrations on fur handling safety, ethics and techniques. There is no charge for the workshop, and students of all ages are welcome. The class will be held from 9 a.m. to 4 p.m. at Spark and Arc Welding, 604 Mitchell St. in Deer Lodge. To register, contact Ed Hebbe III at 406-846-2304. Workshop participants should bring a chair, lunch and dress warmly. ...
Rock Creek Cattle Company in Deer Lodge, MT: View TripAdvisors 5 unbiased reviews, photos, and special offers for Rock Creek Cattle Company, #2 out of 3 Deer Lodge specialty lodging.
Reducing blood oxygen affinity may enhance myocardial oxygen delivery during ischemia. We evaluated this hypothesis in awake, previously instrumented dogs that received a 20 ml/kg infusion of a solution of dihydroxyacetone, phosphate, and pyruvate after acute occlusion of either the left anterior descending or circumflex coronary artery. This infusion reduced blood oxygen affinity (BOA) after 2 hours; the P50 increased from 29.9 +/- 0.7 torr (mean +/- SD) to 32.1 +/- 0.6 torr; P less than 0.01 (BOA group). Four dogs received 20 ml/kg of phosphate and pyruvate solution to assess volume effects (V group), and five dogs were controls (C group). The 2-hour P50 values in V and C were unchanged. Regional flow (15-mum spheres) reduction 2 hours postocclusion was compared to the percent tissue infarcted determined by histology 7-9 days after occlusion for multiple samples from the endocardial layer of the left ventricle. When flow was less than 40% of normal, V and C had 55% infarction while BOA had 37% ...
The Audit and Compliance Committee of the Providence St. Joseph Board of Directors approved and updated the Integrity and Compliance Program Description in 2016. The Integrity and Compliance Program (Program) applies to all Providence ministries including our hospitals, clinics, senior and community service entities, university, high school and others. The Program also applies to Providences wholly owned or controlled entities commonly known as Affiliates, including: Swedish Health Services; Swedish Edmonds; Kadlec Health System; Pacific Medical Centers; and other organizations that may join Providence as an Affiliate unless specifically noted otherwise. Providence and its Affiliates are collectively referred to as "Providence" in all compliance related materials. The Program Description is a high level summary of steps Providence implemented to incorporate recommended compliance program guidance from the Department of Health and Human Services Office of Inspector General. Our Program serves as ...
Kit Component:- KN302227G1, Bpgm gRNA vector 1 in pCas-Guide vector- KN302227G2, Bpgm gRNA vector 2 in pCas-Guide vector- KN302227D, donor vector…
A new, automated technique for collection and instant preparation of blood components has been developed. The device enables the combined collection of red cells (250 mL) and plasma (475 mL). No adverse effects were seen in the donors. The blood components were of good quality. The impact of the pre-separation temperature on whole blood was studied in two studies. In the first study blood was collected and put into stoppered test tubes. The test tubes were then put into water bath at 15,20,25 and 30 °C. Samples were taken at intervals during 24 hours. The lactate concentration increased and 2,3-DPG concentrations decreased during storage and at a higher rate with higher temperature. In the second study blood was collected and dived into half units. One half unit was actively cooled to 20 °C the other half kept at 28 °C. Blood component preparation was done after 6 hours. There were a significant change in 2,3-DPG, pH and lactate already after two hours hold of the whole blood. The differences ...
cytosol, nucleus, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity, phosphoglycerate mutase activity, canonical glycolysis, gluconeogenesis, glycolytic process, regulation of pentose-phosphate shunt
What happened to the Campus at 3600 Wichita Street in Fort Worth where Masonic Home and School was located?. The property was owned by The Grand Lodge of Texas, not the Masonic Home and School. The Grand Lodge of Texas sold the Campus on January 2, 2007. The Grand Lodge transferred the sale proceeds to Square and Compasses Holding, a 501(c)(3) Texas nonprofit corporation. The mineral interests were owned by The Grand Lodge of Texas. The Grand Lodge of Texas did reserve the mineral interests when it sold the Campus on January 2, 2007. The Grand Lodge, however, subsequently conveyed all of the mineral interests to Square and Compasses Holding, a 501(c)(3) Texas nonprofit corporation on September 21, 2007. Square and Compasses Holding will receive any proceeds from the minerals.. What is Square and Compasses Holding?. Square and Compasses Holding is a 501(c)(3) Texas nonprofit corporation. It currently holds proceeds from the sale of the Campus. It also owns the mineral interests from the Campus. ...
Phosphoglycerate mutase deficiency is a disorder that primarily affects muscles used for movement (skeletal muscles). Beginning in childhood or adolescence, affected individuals experience muscle aches or cramping following strenuous physical activity. Some people with this condition also have recurrent episodes of myoglobinuria. Myoglobinuria occurs when muscle tissue breaks down abnormally and releases a protein called myoglobin, which is processed by the kidneys and released in the urine. If untreated, myoglobinuria can lead to kidney failure.. In some cases of phosphoglycerate mutase deficiency, microscopic tube-shaped structures called tubular aggregates are seen in muscle fibers. It is unclear how tubular aggregates are associated with the signs and symptoms of the disorder. ...
Shop Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase ELISA Kit, Recombinant Protein and Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
The isolated minor haemoglobin fractions (haemoglobin D) of ostrich, chicken and duck haemoglobin, which constitute about 30% of total intracellular haemoglobin, form crystalline aggregates upon deoxygenation at physiological temperature, ionic strength and pH and at haemoglobin concentrations even well below those present in the red cell. The aggregation is reversed by oxygenation, and can be inhibited by addition of organic phosphates or the corresponding major haemoglobin fraction in a stoichiometric ratio of 1:1. Embryonic haemoglobin from chicken has similar characteristics with respect to its solubility. The results indicate close functional homology of alpha D and embryonic pi-chains as well as a novel role for organic phosphates in the regulation of haemoglobin function. ...
Western Cape, South Africa hotel deals, Jabula Lodge Hotel deals, Jabula Lodge Hotel reservations, Jabula Lodge Hotel rooms, Southwest Africa hotels, Jabula Lodge Hotel booking, Jabula Lodge Hotel, Western Cape, South Africa deals
Western Cape, South Africa hotel deals, Pumula Lodge Hotel deals, Pumula Lodge Hotel reservations, Pumula Lodge Hotel rooms, Southwest Africa hotels, Pumula Lodge Hotel booking, Pumula Lodge Hotel, Western Cape, South Africa deals
Cyanate therapy of sickle-cell disease is currently under investigation. Since cyanate-treated erythrocytes have increased oxygen affinity, we studied the effect of chronic cyanate administration on tissue oxygen delivery in rats. Sodium cyanate (CNO) was administered for 8 weeks to two groups of rats. Thirty received 625 mg/kg body weight-week orally, and 30 received 250 mg/kg body weight-week intraperitoneally. Control animals received equivalent amounts of NaCl. Animals were killed at 2, 4, and 8 weeks, and blood oxygen affinity (P50), erythrocyte 2, 3-diphosphoglycerate (DPG), hematocrit, and erythrocyte mass were measured. Tissue oxygen delivery was assessed by skin bubble oxygen tension (SBpO2). ...
Press Release issued Sep 21, 2016: Firstly, Dipropylene glycol (DPG) Market report provides a basic overview of the Dipropylene glycol (DPG) industry including definitions, classifications, applications and Dipropylene glycol (DPG) industry chain structure. Global Dipropylene glycol (DPG) Market analysis is provided for the international market including development history, Dipropylene glycol (DPG) industry competitive landscape analysis, and major regions development status on Dipropylene glycol (DPG) Market scenario.
Spectrofluorometric techniques were used to quantify NADPH-hemoglobin interactions based on the quenching of NADPH fluorescence upon binding to hemoglobin. Fluorometric titrations were carried out with hemoglobin in varied states and with hemoglobins in which the beta-chain anion site is altered. At pH 6.5 in 0.05 M 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid buffer, NADPH binds with high affinity, Kd = 1.03 microM, to deoxy human hemoglobin tetramers. Lower affinity binding of NADPH occurs as the beta-chain anion-binding site is discharged by increasing the pH. Moreover, the cofactor binds in a 1:1 ratio to deoxy tetramers, inositol hexaphosphate binds competitively, and binding is decreased in hemoglobins whose structural alterations result in decreased effects of 2,3-diphosphoglycerate. The cofactor binds to oxidized (met) hemoglobin with an estimated Kd of 33.3 microM but has little or no affinity for the oxy form. These results indicate that NADPH binds at the beta-chain ...
Units of blood were divided into 5 aliquots and were stored at 4 C. in ACD without additive or supplemented with adenine, inosine, inosine adenine, or adenosine. Adenine and nucleoside were added in an amount of 0.75 and 15 micro moles per ml ACD-blood, respectively. After storage for 6 weeks, 24 hour post-transfusion survival of the erthrocytes was determined. Survival of the erthrocytes was significantly increased when the ACD was supplemented with any of the additives. There was, however, no significant difference in the effect of any one of the additives. The glycolytic intermediates of erythrocytes stored for the same period with the same additives were studied after separation on columns of ion-exchange resin. No adenosine triphosphate (ATP) or 2,3-diphosphoglycerate (DPG) remained in the blood stored in ACD alone. Supplementation of ACD with adenine resulted in no qualitative or quantitative change in the intermediates. ATP and DPG remained in the erythrocytes stored in ACD ...
The Phosphoglycerate Kinase 1 is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19.PGK1 is distinguished from testicular PGK2, which maps to chromosome 6p21. The deduced protein contains 417 amino acid residues. Southern blot analysis of human genomic DNAs showed a complex pattern of hybridizing fragments, 2 of which were non-X in origin. The results were interpreted as reflecting the existence of a small family of dispersed PGK or PGK-like genes.
Stroma-free hemoglobin cross-linked with reagents that mimic 2,3 diphosphoglycerate and transform stroma-free hemoglobin into a physiologically competent oxygen carrier which is retained in vivo for adequate periods of time and thus can be used in fluids for transporting oxygen; reagents for cross-linking stroma-free hemoglobin and method for cross-linking stroma-free hemoglobin.
PURPOSE: Phosphorus magnetic resonance spectroscopy ((31)P-MRS) affords unique insight into cardiac energetics but has a low intrinsic signal-to-noise ratio (SNR) in humans. Theory predicts an increased (31)P-MRS SNR at 7T, offering exciting possibilities to better investigate cardiac metabolism. We therefore compare the performance of human cardiac (31)P-MRS at 7T to 3T, and measure T1s for (31)P metabolites at 7T. METHODS: Matched (31)P-MRS data were acquired at 3T and 7T, on nine normal volunteers. A novel Look-Locker CSI acquisition and fitting approach was used to measure T1s on six normal volunteers. RESULTS: T1s in the heart at 7T were: phosphocreatine (PCr) 3.05 ± 0.41s, γ-ATP 1.82 ± 0.09s, α-ATP 1.39 ± 0.09s, β-ATP 1.02 ± 0.17s and 2,3-DPG (2,3-diphosphoglycerate) 3.05 ± 0.41s (N = 6). In the field comparison (N = 9), PCr SNR increased 2.8× at 7T relative to 3T, the Cramer-Ráo uncertainty (CRLB) in PCr concentration decreased 2.4×, the mean CRLB in PCr/ATP decreased 2.7× and the ...
The East Providence Lodge works with the Elks National Foundation by Earning a Gratitude Grant. The goal for this grant is set by the Grand Exalted Ruler. The ENF team members at the lodge met this …
In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent ...
Sperm proteins are important for the sperm cell function in fertilization. Some of them are involved in the binding of sperm to the egg. We characterized the acrosomal sperm protein detected by a monoclonal antibody (MoAb) (Hs-8) that was prepared in our laboratory by immunization of BALB/c mice with human ejaculated sperms and we tested the possible role of this protein in the binding assay. Indirect immunofluorescence and immunogold labelling, gel electrophoresis, Western blotting and protein sequencing were used for Hs-8 antigen characterization. Functional analysis of GAPDHS from the sperm acrosome was performed in the boar model using sperm/zona pellucida binding assay. Monoclonal antibody Hs-8 is an anti-human sperm antibody that cross-reacts with the Hs-8-related protein in spermatozoa of other mammalian species (boar, mouse). In the immunofluorescence test, Hs-8 antibody recognized the protein localized in the acrosomal part of the sperm head and in the principal piece of the sperm flagellum. In
Authors: Freitas, J. , Braz-Nogueira, J. , Nogueira da Costa, J. , Martins e Silva, J. Article Type: Research Article Abstract: Twenty one ambulatory patients with essential hypertension (10 men, 11 women), 50.6±6.3 years old, had blood pressures of 167.5±17.1 mmHg for systolic and l06.2±9.9 mmHg for diastolic. Most of them were under treatment and target organ involvement was not important. Several parameters were calculated from a sample of venous blood: haemoglobin, haematocrit, P50 standard, carboxyhaemoglobin, red cell 2,3-diphosphoglycerate and erythrocyte filterability rate. As significant different from a group of control, it has been found a higher P50 standard (hypertensives 29.07±1.82 mmHg. vs. controls 27.74±0.86 mmHg, p , 0.05) and a lower filterablity rate (11.41±1.31 μ l.sec−l for hypertensives 15.80±0.83 …μ l.sec−l for controls, p , 0.001). The results suggest an augmentation of the rigidity of red blood cells that may have consequences on microcircultion and ...
SOUTH SAN FRANCISCO, Calif., Oct. 07, 2016 (GLOBE NEWSWIRE) - Global Blood Therapeutics, Inc. (GBT) (NASDAQ:GBT), a biopharmaceutical company developing novel therapeutics for the treatment of grievous blood-based disorders with significant unmet needs, today announced that an encore presentation of the GBT440-001 study data supporting the durability, safety and mechanism of action of GBT440 in sickle cell disease were presented today in an oral session at the Academy for Sickle Cell and Thalassemia (ASCAT) 10th Anniversary Conference in London.. "Hemoglobin oxygen affinity modulation is a very promising approach for modifying disease in SCD because it intervenes on the fundamental pathologic process- HbS polymerization. GBT440 is an exciting hemoglobin modifier in development because of excellent specificity and pharmaceutical properties resulting in both increased potency and an improved safety profile. Over three months of dosing, GBT440 has shown profound and durable reductions in hemolysis ...
Phosphofructokinase 2 (PFK2) or fructose bisphosphatase 2 (FBPase2), is an enzyme responsible for regulating the rates of glycolysis and gluconeogenesis in the human body. It is a homodimer of 55 kDa subunits arranged in a head-to-head fashion, with each polypeptide chain consisting of independent kinase and phosphatase domain. When Ser-32 of the bifunctional protein is phosphorylated, the negative charge causes the conformation change of the enzyme to favor the FBPase2 activity; otherwise, PFK2 activity is favored. The PFK2 domain is closely related to the superfamily of mononucleotide binding proteins including adenylate cyclase, whereas that of FBPase2 is related to a family of proteins that include phosphoglycerate mutases. The monomers of the bifunctional protein are clearly divided into two functional domains. The kinase domain is located on the N-terminal. It consists of a central six-stranded β sheet, with five parallel strands and an antiparallel edge strand, surrounded by seven α ...
Dromedary Jumping-slug, Hemphillia dromedarius, is an old-growth coniferous forest-dwelling slug endemic to southern British Columbia (B.C.) and western Washington, with unconfirmed records in northern Oregon. The species exists at the northernmost limits of its range in south western B.C. with a known Canadian range extent of approximately 4000 km2 confined to southern Vancouver Island. The species was located and confirmed in Canada in 1999. As of 2008, 15 locations have been defined for Dromedary Jumping-slug, with eight of these locations in protected areas. Additional undocumented localities likely exist, although the range extent is not likely to expand significantly. The Committee on the Status of Endangered Wildlife in Canada (COSEWIC) designated Dromedary Jumping-slug as Threatened in 2003, due to the fragmentation of its coniferous forest habitats and threats to the remaining habitats, mainly from forestry activities.
Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease that can be transmitted from dromedaries to human beings. Up to December 2016, a total of 1841 cases of laboratory-confirmed MERS-CoV infection were reported to the World Health Organization, with an overall case fatality rate of 35% [1]. The current status of knowledge around MERS-CoV in dromedaries in Morocco still unknow. This article is a prospective study in dromedary herd during one year 2016 in the south of morocco. Faecal samples and nasal swabs of camels were analyzed for identification of viral sequences using specific polymerase chain reaction (PCR) methods.. ...
GAPDHS (the sperm-specific glyceraldehyde phosphate dehydrogenase, also known as GAPD2, GAPDS, HSD-35, or GAPDH-2, is a glycolytic enzyme that plays an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. It can be used as an intra-acrosomal marker for evaluation of the physiological state of sperm cells as well as for selection of a suitable method of fertilization in the laboratories of assisted reproduction ...
Here again is a potential limiting factor for this pathway. The continuation of the reaction depends upon the availability of the oxidized form of the electron carrier, NAD+. Thus, NADH must be continuously oxidized back into NAD+ in order to keep this step going. If NAD+ is not available, the second half of glycolysis slows down or stops. If oxygen is available in the system, the NADH will be oxidized readily, though indirectly, and the high-energy electrons from the hydrogen released in this process will be used to produce ATP. In an environment without oxygen, an alternate pathway (fermentation) can provide the oxidation of NADH to NAD+.. Step 7. In the seventh step, catalyzed by phosphoglycerate kinase (an enzyme named for the reverse reaction), 1,3-bisphosphoglycerate donates a high-energy phosphate to ADP, forming one molecule of ATP. (This is an example of substrate-level phosphorylation.) A carbonyl group on the 1,3-bisphosphoglycerate is oxidized to a carboxyl group, and ...
Of the combinations tried, the admixture of methylene blue, progesterone, adenine and inosine maintained 2,3-diphosphoglycerate and adenosine triphosphate at high levels in citrate-phosphate-dextrose blood for a storage period of 6 weeks, about equal to those of the control values on the day of collection. (Author)(*BLOOD
HEADER ISOMERASE 19-JUL-00 1E59 TITLE E.COLI COFACTOR-DEPENDENT PHOSPHOGLYCERATE MUTASE COMPLEXED TITLE 2 WITH VANADATE COMPND MOL_ID: 1; COMPND 2 MOLECULE: PHOSPHOGLYCERATE MUTASE; COMPND 3 CHAIN: A; COMPND 4 EC: 5.4.2.1; COMPND 5 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI; SOURCE 3 ORGANISM_TAXID: 83333; SOURCE 4 STRAIN: K12; SOURCE 5 GENE: PGM1; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3); SOURCE 9 EXPRESSION_SYSTEM_PLASMID: PET3A KEYWDS INHIBITOR, VANDATE, GLYCOLYSIS AND GLUCONEOGENESIS, KEYWDS 2 PHOSPHOGLYCERATE MUTASE, ISOMERASE EXPDTA X-RAY DIFFRACTION AUTHOR C.S.BOND,W.N.HUNTER REVDAT 3 24-FEB-09 1E59 1 VERSN REVDAT 2 15-MAR-02 1E59 1 JRNL REVDAT 1 05-FEB-02 1E59 0 JRNL AUTH C.S.BOND,M.WHITE,W.N.HUNTER JRNL TITL MECHANISTIC IMPLICATIONS FOR ESCHERICHIA COLI JRNL TITL 2 COFACTOR-DEPENDENT PHOSPHOGLYCERATE MUTASE BASED JRNL TITL 3 ON THE HIGH-RESOLUTION CRYSTAL ...
GE BPG 140-950 14.5L Chromatography Column Excellent USED Condition. 30 Day Money Back Guarantee!!! BPG columns are glass chromatography c
Buy Bpg 1000000IU Injection - vial of 1 Injection at online at 1mg.com. Know the uses, side effects, price, composition, substitutes, How it works, Precautions and Expert Advice for Bpg 1000000IU Injection manufactured by Alembic Pharmaceuticals Ltd
Isolation and characterization of cytochrome oxidase protein subunits from mammalian mitochondria and two micro-organisms (Thermophilic bacteria P53 and Thiobacillus ferrioxidans). Our goal is to compare the common protein subunits and their individual functions. The procedures to identify these subunits are by Elisa and Western blot analyses using polyclonal and monoclonal antibodies previously prepared against the mammalian species. So far, we have found that the three largest subunits are common in all cytochrome oxidase samples, while little information is known about the smaller subunits. Our eventual aim is to understand the detailed enzyme mechanism of this important terminal member of electron transport chain and its contribution to energy transduction ...
Heart of Italy Tour by Abruzzo World Club throughout the Summer 2003 to some of the unspoiled treasures of Central Italy: Abruzzo, Umbria, Marche e Lazio
Hence blood with high carbon dioxide levels is also lower in pH (more acidic). Hemoglobin can bind protons and carbon dioxide which causes a conformational change in the protein and facilitates the release of oxygen. Protons bind at various places along the protein, and carbon dioxide binds at the alpha-amino group forming carbamate. Conversely, when the carbon dioxide levels in the blood decrease (i.e., in the lung capillaries), carbon dioxide and protons are released from hemoglobin, increasing the oxygen affinity of the protein. This control of hemoglobins affinity for oxygen by the binding and release of carbon dioxide and acid, is known as the Bohr effect. The binding of oxygen is affected by molecules such as carbon monoxide (CO) (for example from tobacco smoking, cars and furnaces). CO competes with oxygen at the heme binding site. Hemoglobin binding affinity for CO is 200 times greater than its affinity for oxygen, meaning that small amounts of CO dramatically reduce hemoglobins ...
Background: Sickle cell disease (SCD) is a genetic disorder in which deoxygenation produces polymerization of mutated hemoglobin S (HbS) and triggers the downstream effects of red blood cell deformation (sickling), hemolysis, vaso-occlusion and inflammation. Injury from SCD starts in infancy and accumulates over a lifetime causing significant end-organ damage and ischemic tissue injury, leading to fatigue, pain (vaso-occlusive crisis) and other clinical complications that are under-recognized, under-treated, and associated with early death. GBT440 is an oral, once-daily therapy that modulates hemoglobin affinity for oxygen, thereby inhibiting hemoglobin polymerization. GBT440-007 is a Phase 2a study designed to assess the safety, pharmacokinetics (PK) and efficacy of GBT440 in pediatric SCD patients (HbSS or HbSβ0 thalassemia). This abstract reports the first evaluation of multiple doses of GBT440 in adolescents (12 to 17 years) with SCD. Methods: This ongoing study is being conducted in 2 ...
HbF has greater attraction to O2 than Hb low % O2 by time blood reaches placenta fetal Hb must be able to bind O2 with greater attraction than maternal Hb Both mother and fetus share a common blood supply. In particular, the fetuss blood supply is delivered via the umbilical vein from the placenta, which is anchored to the wall of the mothers uterus. As blood courses through the mother, oxygen is delivered to capillary beds for gas exchange, and by the time blood reaches the capillaries of the placenta, its oxygen saturation has decreased considerably. In order to recover enough oxygen to sustain itself, the fetus must be able to bind oxygen with a greater affinity than the mother. Fetal hemoglobins affinity for oxygen is substantially greater than that of adult hemoglobin. Notably, the P50 value for fetal hemoglobin (i.e., the partial pressure of oxygen at which the protein is 50% saturated; lower values indicate greater affinity) is roughly 19 mmHg, whereas adult hemoglobin has a value of ...
Middle Eastern respiratory syndrome coronavirus (MERS-CoV), first identified in the fall of 2012 in a Saudi Arabian patient, has since infected over 180 individuals, causing 77 deaths. Antibodies to the virus and the viral genome have been found in dromedary camels in Jordan and Saudi Arabia, implicating those animals as the source of human infections. A new study reveals that the virus has infected camels throughout Saudi Arabia since at least 1992.. Serum, blood, and rectal and nasal swabs were collected from dromedary camels in November-December 2013 from southwestern, western, northwestern, eastern, and central regions of the Kingdom of Saudi Arabia. Of 203 serum samples, 150 (74%) were found to contain antibodies to MERS-CoV. The number of seropositive animals varied from 5% to 95% depending on location and the age of the animals (in general, seropositivity was higher in adult camels compared with young camels). Antibodies against MERS-CoV were also detected in archived serum samples from ...
The researchers examined nasal samples collected during a countrywide survey of dromedary camels and selected samples from two animals with the highest viral load. They cultured and obtained complete genomic sequence from both animals as well as virus in nasal samples from several other camels.. The mathematical means of all genetic sequences (the consensus genomic sequences) were consistent with viruses found in human cases; however, samples from camels contained more than one virus genotype. Over a period of 48 hours of culture in primate cells, the genomic variation of viruses narrowed, mirroring the lower sequence diversity reported in MERS-CoV found in humans.. "The finding of infectious virus strengthens the argument that dromedary camels are reservoirs for MERS-CoV," says first author Thomas Briese, PhD, associate director of the Center for Infection and Immunity and associate professor of Epidemiology at the Mailman School. "The narrow range of MERS viruses in humans and a very broad ...
dynamical England, download nonlinear markov processes and kinetic equations hyper-, conduit. harmony Cynesige of York. Rheims in the such environment.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Expression of CDC42BPG (DMPK2, HSMDPKIN, kappa-200, MRCKgamma) in lung tissue. Antibody staining with HPA027382 and HPA061836 in immunohistochemistry.
Expression of CDC42BPG (DMPK2, HSMDPKIN, kappa-200, MRCKgamma) in fallopian tube tissue. Antibody staining with HPA027382 and HPA061836 in immunohistochemistry.
Glyceraldehyde-3-phosphate dehydrogenase (NADP+)(phosphorylating); Involved in the photosynthetic carbon assimilation. Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phos [...] (337 aa ...
The effect of reducing hemoglobin affinity for O2 on fetal oxygenation was assessed in seven fetal lambs in which fetal blood was almost completely replaced by maternal blood 2-3 days postoperatively. Measurements of fetal blood gases and organ blood flow (radionuclide-labeled microsphere technique) were obtained before and 1 h after the exchange transfusion. Umbilical venous blood PO2 increased from 29 +/- 5 to 35 +/- 6 (SD) Torr (P less than 0.001) but hemoglobin O2 saturation decreased from 78.2 +/- 10.3 to 39.8 +/- 8.8% (P less than 0.001), resulting in a 46% decrease in umbilical venous blood O2 content. Since umbilical-placental blood flow also decreased (P less than 0.002), O2 delivery to the fetus decreased by 64% (P less than 0.002). Although O2 extraction increased from 32.5 +/- 6.8 to 50.9 +/- 9.0% (P less than 0.002), fetal O2 consumption fell from 7.28 +/- 1.97 to 4.10 +/- 1.20 ml X min-1 X kg-1 (P less than 0.02), and metabolic acidemia developed. No significant change in fetal ...
Physiology Test Question - A higher numerical value of oxygen (O2) P50 indicates a higher hemoglobin affinity for O2. Note: O2 P50 is the oxygen partial pressure (PO2) at which 50% of hemoglobin molecules are saturated with O2.
Mariposa Lodge: The pool is not big but ok for the kids since it... - See 618 traveler reviews, 172 candid photos, and great deals for Mariposa Lodge at TripAdvisor.
... Offering free WiFi and free onsite parking, Cascades Motor lodge is located in Pakuranga, Auckland. Surrounded by lovely gardens, all accommodation includes cooking facilities.
2016 Wildwood Lodge DLX 402QBQ available at Greeneway RV Sales and Service. WILDWOOD LODGE DLX Seamless Walk on RoofTriple Sealed SlideoutsIn-Floor Ducted HeatDucted Central A/CWater Heater By-PassDSI Water HeaterFlush-Floor Slide RoomsSystems Monitor PanelStain Resistant Carpet DVD/CD/AM/FM MP3Surround SoundHigh Rise Kitchen FaucetRange w/OvenRefrigeratorMicrowaveThermoform CountertopsFoot Flush Toilet
2018 Wildwood Lodge 393RLT available at Greeneway RV Sales and Service. WILDWOOD LODGE Seamless Walk on RoofTriple Sealed SlideoutsVinyl AwningExterior SpeakersIn-Floor Ducted Heat35k BTU Furnace15K BTU Ducted A/CWater Heater By-PassDSI Water HeaterFlush-Floor Slide RoomsSystems Monitor PanelStain Resistant Carpet Entertainment CenterKitchen SkylightHigh Rise Kitchen FaucetRange w/OvenRefrigeratorMicrowaveFoot Flush Toilet
... Located opposite the University of Canterbury, Academy Motor Lodge offers a free parking and accommodation with a satellite TV.
Pinetucket Lodge, 8 Unlimited Use Sharc Passes, Complementary Cruiser Bikes . Pinetucket Lodge sleeps up to eight guests. We are nestled in the heart of t...
In order to determine whether daily exposure to methylene chloride (75092) vapors affects hemoglobin affinity for oxygen and/or pulmonary function, four healthy young males aged 22 to 24 years were exposed for 7-1/2 hours per day for 26 days in an environmental chamber over 6 consecutive weeks to various concentrations (0 to 50ppm) of methylene-chloride vapor. Effects of the vapor on pulmonary air
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
... Weather forecast up to 14 days including temperature, weather condition and precipitation and much more.
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015 ...
GT:ID BAD56223.1 GT:GENE BAD56223.1 GT:PRODUCT putative phosphoglycerate mutase GT:DATABASE GIB00210CH01 GT:ORG nfar0 GB:ACCESSION GIB00210CH01 GB:LOCATION 1542838..1543497 GB:FROM 1542838 GB:TO 1543497 GB:DIRECTION + GB:PRODUCT putative phosphoglycerate mutase GB:PROTEIN_ID BAD56223.1 LENGTH 219 SQ:AASEQ MSKYAGVRTLILLRHGQTEWNATDRMQGQIDTDLTELGRRQAKEAARELVSRNAIAIVSSDLRRAHDTALALAEHTDVPVALDPRLRETHLGDWQGLTHLEVDADYPGARVAWRLDATYRPPGGESKLEVGARALPVVRELYNERQDWPGRTIILVAHGGLIAALTAALLELPPQNWPALGGLANTSWVQLSSHGPGIDQPGWRLDVWNAAAKVAPDVL GT:EXON 1,1-219:0, BL:SWS:NREP 1 BL:SWS:REP 8-,136,GPMA_NITWN,4e-19,42.6,129/207, PROS 12-,21,PS00175,PG_MUTASE,PDOC00158, SEG 157-,172,ahggliaaltaallel, BL:PDB:NREP 1 BL:PDB:REP 9-,156,1h2eA,2e-22,40.0,145/207, RP:PDB:NREP 1 RP:PDB:REP 8-,209,1ebbA,8e-30,32.0,194/202, RP:PFM:NREP 1 RP:PFM:REP 10-,156,PF00300,2e-23,45.8,144/158,PGAM, HM:PFM:NREP 1 HM:PFM:REP 9-,165,PF00300,3.7e-45,40.0,155/158,PGAM, RP:SCP:NREP 1 RP:SCP:REP 8-,209,1ebbA,3e-30,32.0,194/202,c.60.1.1, HM:SCP:REP ...
This discovery led to the testing of other combinations. It is now known that many pairs of organic phosphate insecticides are highly dangerous, the toxicity being stepped up or "potentiated" through the combined action. Potentiation seems to take place when one compound destroys the liver enzyme responsible for detoxifying the other. The two need not be given simultaneously. The hazard exists not only for the man who may spray this week with one insecticide and next week with another; it exists also for the consumer of sprayed products. The common salad bowl may easily present a combination of organic phosphate insecticides. Residues well within the legally accessible limits may interact.. The full scope of the dangerous interaction of chemicals is as yet little known, but disturbing findings now come regularly from scientific laboratories. Among these is the discovery that the toxicity of an organic phosphate can be increased by a second agent that is not necessarily an insecticide. For ...
DPG(D) Chemical Name:Diphenyl guanidine Structure: Molecular Formula:C13H13N3 Molecular Weight:211.27 CAS NO:102-06-7 Specification: Item Powder Oiled powder Granule Appearance Gray-white powder(granule) Initial M.P.οC≥ 145.0 145.0 145.0 Loss on drying%≤ 0.30 0.40 0.30 Ash%≤ 0.30 0.40 0.30 Residues on150μm sieve, %≤ 0.10 0.10 / Residues on63μm), %≤ 0.50 0.50 / Additive, % / 0.0-2.0 / Granule Diameter, mm / / 1.50 Properties:Grayish-white powder(granule)No taste, no poison. Densiy is 1.08--1.19. Soluble in acetone, ethyl acetate, benzene, alcohol, slightly soluble in CCl4; Insoluble in water and gasoline. Application:Used as a secondary accelerator with thiazoles and sulphenamides in NR and SBR compounds. Exhibits better storage stability compared to thiuram and dithiocarbamates but is not so active. DPG can be used in latex as secondary gelling agent (foam stabilizer) in the silico-flouride foam process. Packaging:25kg bag. Storage:Keep container tightly closed in a cool, ...
Global Dipropylene Glycol (DPG) Sales Market by Manufacturers, Types, Regions and Application & Forecast to 2025(Shopping-NewsWire.com, January 12, 2018 ) Global Dipropylene Glycol (DPG) Sales Market report is replete with detailed analysis from a thorough research, especially on questions that bo
[104 Pages Report] Check for Discount on Global Dipropylene Glycol (DPG) Market Research Report 2017 report by QYResearch Group. In this report, the global Dipropylene Glycol (DPG) market is...
Cultivated cassava (Manihot esculenta) has a higher rate of photosynthesis than is usual for C3 plants and photosynthesis is not light saturated. For these reasons it has been suggested that cultivated cassava could be derived from wild species possessing C4 photosynthesis. The natural abundance of 13C and activities of phosphoenolpyruvate carboxylase and phosphoglycolate phosphatase were measured in leaves of 20 wild cassava species to test this hypothesis. All the species studied, including M. flabellifolia the potential wild progenitor of cultivated cassava, clearly exhibited C3 not C4 characteristics ...
1EQJ: Mechanism of catalysis of the cofactor-independent phosphoglycerate mutase from Bacillus stearothermophilus. Crystal structure of the complex with 2-phosphoglycerate.
Pgam2 - Pgam2 (Myc-DDK-tagged ORF) - Rat phosphoglycerate mutase 2 (muscle) (Pgam2), (10 ug) available for purchase from OriGene - Your Gene Company.
DROMEDARY COOK BOOK SPECIAL COLLECTIONS THE LIBRARY OF THE UNIVERSITY OF CALIFORNIA LOS ANGELES ,E take this opportunity of presenting to the American Housewife a col- lection of recipes which have to do with a class of food products but little known. The dietetic value of such fruits as dates, figs, currants, etc., is a high one and these fruits should appear on our tables at least once a day. The brands mentioned are all standard and some of them have been on the market for the last twenty-five years. The recipes are all based on the use of the best grades of the various products and these brands stand for the highest quality as well as for absolute cleanliness of pack. Any good fruit dealer or grocer can supply them. The recipes which we have published in this little book have been selected from a large number submitted in our prize contest held in 1910. They have been thoroughly tested and we hope will meet with the approval of all who have occasion to use them. THE HILLS BROTHERS COMPANY ...
Shop Oman, Wadi darbat, dromedaries pasturing in the Jigsaw Puzzle created by DanitaDelimont. Personalize it with photos & text or purchase as is!
Die Dromedary Bags von MSR sind expeditionstaugliche Bombertaschen, die den härtesten Bedingungen und hohen Anforderungen standhalten.
gpmA; highly similar to 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp,A6T6I3); K01834 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] ...
1E58: High Resolution Structure of the Phosphohistidine-Activated Form of Escherichia Coli Cofactor-Dependent Phosphoglycerate Mutase.
This nursing Best Practice Guideline (BPG) is intended to replace the RNAO BPG Client Centred Care (2002) and its supplement (2006). It is to be used by nurses and other members of the interprofessional health-care team ...
Bi alîkariya ava mîdeyê, ku bi asîd pêkhatiye û bi alîkariya enzîman (li livikên -tosbiyên- bedenê mirovan da tên çêkirin û ji bo hezmê u pir tiştên din hewce ne) xwarin tê hezimkirin. Mîde kareki wek ambar pêktîne û xwarinê perçe perçe dide rûviya danzdeh gire, him ji destpêka hezma xwarine dike. Dawiya wê rûviya zirav tê, ku 3 metre dirêjiya xwe heye. Dawî rûviya zirav xwarin tê û digiheje rûviya stûr. Rûviya stûr nêzîkî 1,5 metre dirêj e.. Nava gedekê bi giştî gelek tirş e. Rêje ya tirşatî ya gedekê anko pH a gedekê, di navbera 1 heta 4ê da ye. Xaneyên serekî yên gedekê maddeyekî bi navê pêpsînosênê dirêjin nav gedekê ko bi tirşê hîdroklorîk dibit pêpsîn. Gedek rojane 2 heta 4 lîtreyên şîrê gedekê dirêjit.. ...
We have Oracle 9.2.0.4 running on Red Hat AS 2.1. We are considering upgrading the operating system to Red Hat AS 3.0 or Red Hat AS 4.0. Oracle 9.2.0.4 appears to be certified on Red Hat AS 3.0 but Im not sure if there are any steps that need to be done to protect Oracle 9.2.0.4 and have it work on Red Hat AS 3.0? Also, is it true that Oracle 9.2.0.4 is not certified on Red Hat AS 4.0?
K01834 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] , (GenBank) gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate ...
Did you know that scientists have successfully crossbred camels with llamas a couple of times? It only works when the male is a Dromedary (artificial insemination is required), but since both species have 74 chromosomes, there is potential for the Cama (as the hybrid is known) to be fertile, thus spawning a new work animal (they already have half Dromedary / half Bactrians called Bukhts). But, alas, the cama inherited the poor temperament of both parents. Lovely. ...
HELIX DETERMINATION METHOD: PROCHECK, WITH IDENTIFICATION CORRESPONDING TO 2.0A L. MESENTEROIDES STRUCTURE, 1DPG. HELIX_ID: A,BEND AT K21 IS CONSEQUENCE OF CONSERVED P24. HELIX_ID: D,THE FIRST TURN IS 3_10 (CLASS 5). HELIX_ID: F,THE FIRST 2 TURNS ARE 3_10 (CLASS 5). HELIX_ID: H,G231 BRIDGES H & I' SO IS NOT HELICAL. HELIX_ID: I',PART OF HELIX I IN 1DPG. RESIDUES 235-239 DISTORTED BY SIDECHAIN INTERACTION OF N239 WITH D235 ...
dpG antibodies were fractionated on a cellulose-double-stranded DNA column. The flow-through fraction bound denatured DNA but not double-stranded DNA (dsDNA). The dpG-eluted fraction bound dsDNA preferentially. The results show that proteins can recognise dpG in DNA by different mechanisms, some involving DNA unwinding.. ...
The Chicago Bulls announced today the team has exercised its fourth-year option for the 2012-13 season for forward Taj Gibson.. In two seasons with Chicago, Gibson (6-9, 225) has appeared in 162 games (89 starts) and averaged 8.0 ppg, 6.6 rpg, and 1.30 bpg in 24.4 mpg; he has shot .485 from the field and .659 from the line. The Bulls selected Gibson in the first round (26th overall) in the 2009 NBA Draft.. InsideHoops.com editor says: This was an easy call for the Bulls. Gibson is a very solid backup forward who is capable of starting for stretches.. ...
Mitsubishi Motors Corporation, with cooperation from the Aichi Industrial Technology Institute (Kariya, Aichi Prefecture), has developed an automotive interior material which uses a plant-based resin, polybutylene succinate (PBS), combined with bamboo fiber
Gaddafis got the hump : Benghazi The Libyan Camel Racing Association has petitioned Colonel Gaddafi about ritual interference to his prized dromedary Apparently the mad old despot has been overmilking his favorite beastie to make camel cheese and butter But an ac
We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time.Find out more ...
Hemoglobin below age appropriate norms (Reduction in O2 transport to tissues -, tissue hypoxia -, compensation (increased CO, increased 2,3DPG)). Pathophysiology. ...
3500 MOUNTAIN BLVD., OAKLAND, CALIFORNIA 94619 , 510.436.1000. Holy Names University (HNU) does not discriminate on the basis of race, color, age, sex, sexual orientation, religion, physical/mental disability, marital status, or national or ethnic origins in the administration of its educational or admission policies, scholarships and loan programs, and athletic and other University administered programs.. HNU Privacy Policy. ...
KEGG ENZYME: 5.4.2.4  KEGG ENZYME: 5.4.2.4
diphosphoglycerate mutase;. glycerate phosphomutase;. bisphosphoglycerate synthase;. bisphosphoglyceromutase;. ... Pathway (4) KEGG PATHWAY (4) Chemical substance (2) KEGG COMPOUND (2) Chemical reaction (2) KEGG REACTION (1) KEGG RCLASS (1) ... 2,3-diphosphoglycerate mutase;. phosphoglyceromutase;. 2,3-diphosphoglycerate synthase;. DPGM;. 2,3-bisphosphoglycerate mutase; ... The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3 ...
more infohttp://www.genome.jp/dbget-bin/www_bget?ec:5.4.2.4
Phosphoglycerate/bisphosphoglycerate mutase, active site (IPR001345) | InterPro | EMBL-EBI  Phosphoglycerate/bisphosphoglycerate mutase, active site (IPR001345) | InterPro | EMBL-EBI
Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.. Proc. Natl. Acad. Sci. U.S.A. 86 ... Molecular cloning and nucleotide sequence of murine 2,3-bisphosphoglycerate mutase cDNA.. Biochem. Biophys. Res. Commun. 156 ... A number of other proteins including, the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase [PMID: ... Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR001345
GFIT result for T02514  GFIT result for T02514
2. --. probable phosphoglycerate mutase. , sec:SCH_0770(250). 250. 92.4. 1571. (1420). 0. --. K01834 PGAM [sp:GPMA_SALCH] gpmA ... 3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]. , pato:GZ59_14180(250). 250. 98.4. 1640. 0. <-. K01834 ... 3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]. , patr:EV46_06995(250). 250. 98.4. 1640. 0. <-. K01834 ... 3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]. , sry:M621_06515(250). 250. 93.2. 1594. 0. --. K01834 ...
more infohttp://www.kegg.jp/ssdb-bin/www_ssget?pec:W5S_3063
PDB: 1E59  PDB: 1E59
Chemical substance (2) PDB-CCD (2) Chemical reaction (1) KEGG ENZYME (1) Protein sequence (4) UniProt (2) SWISS-PROT (1) PDBSTR ... REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : SHELXL-97 REMARK 3 AUTHORS : G.M.SHELDRICK REMARK 3 REMARK 3 DATA USED IN ... REMARK 3 OCCUPANCY SUM OF NON-HYDROGEN ATOMS : 2210.50 REMARK 3 OCCUPANCY SUM OF HYDROGEN ATOMS : 0.00 REMARK 3 NUMBER OF ... REMARK 3 BOND LENGTHS (A) : 0.013 REMARK 3 ANGLE DISTANCES (A) : 0.029 REMARK 3 SIMILAR DISTANCES (NO TARGET VALUES) (A) : ...
more infohttp://www.genome.jp/dbget-bin/www_bget?pdb:1E59
G304 | Phosphoglycerate Kinase 1 (PGK1)- Cloud-Clone Corp.  G304 | Phosphoglycerate Kinase 1 (PGK1)- Cloud-Clone Corp.
Southern blot analysis of human genomic DNAs showed a complex pattern of hybridizing fragments, 2 of which were non-X in origin ... The Phosphoglycerate Kinase 1 is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3- ... 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]. *"Initial characterization of the human central proteome."BMC Syst. Biol. 5: ... "Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase]."Gene 32:409-417(1984) [PubMed] [ ...
more infohttp://www.cloud-clone.com/items/G304.html
2,3-bisphosphoglycerate, diphosphoglycerate | definition of 2,3-bisphosphoglycerate, diphosphoglycerate by Medical dictionary  2,3-bisphosphoglycerate, diphosphoglycerate | definition of 2,3-bisphosphoglycerate, diphosphoglycerate by Medical dictionary
... diphosphoglycerate in the Medical Dictionary? 2,3-bisphosphoglycerate, diphosphoglycerate explanation free. What is 2,3- ... bisphosphoglycerate, diphosphoglycerate? Meaning of 2,3-bisphosphoglycerate, diphosphoglycerate medical term. What does 2,3- ... diphosphoglycerate. 2,3-bisphosphoglycerate, diphosphoglycerate. a product of glucose metabolism; binds strongly to ... 2,3-bisphosphoglycerate, diphosphoglycerate , definition of 2,3-bisphosphoglycerate, diphosphoglycerate by Medical dictionary ...
more infohttp://medical-dictionary.thefreedictionary.com/2%2C3-bisphosphoglycerate%2C+diphosphoglycerate
Relationship of 2,3-diphosphoglycerate and 2,3-diphosphoglycerate mutase in various mammals.  Relationship of 2,3-diphosphoglycerate and 2,3-diphosphoglycerate mutase in various mammals.
To investigate a possible mechanism involved in the regulation of 2,3-diphosphoglycerate (2,3-DPG) synthesis, 2,3-DPG mutase ( ... DPGM) was measured in different mammals presenting large differences in 2,3-DPG concentration between fetal, neonatal and ad ... The data demonstrated that the minimal levels of 2,3-DPG in the adult sheep are likely due to the very low levels of DPGM. Also ... 2,3-Diphosphoglycerate. Aging. Animals. Animals, Newborn. Bisphosphoglycerate Mutase / blood*. Diphosphoglyceric Acids / ...
more infohttp://www.biomedsearch.com/nih/Relationship-23-diphosphoglycerate-mutase-in/6248136.html
Interlaboratory comparison of red-cell ATP, 2,3-diphosphoglycerate and haemolysis measurements.  Interlaboratory comparison of red-cell ATP, 2,3-diphosphoglycerate and haemolysis measurements.
... Hess, J R ... 2;3-Diphosphoglycerate/*analysis, Adenosine Triphosphate/*analysis, Biological Markers/analysis, Blood Preservation/*standards ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:53516
Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate Concentration, and Increased Hemoglobin-Oxygen...  Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate Concentration, and Increased Hemoglobin-Oxygen...
LICHTMAN MA, MILLER DR, COHEN J, WATERHOUSE C. Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate ... A marked reduction in red cell glucose utilization, lactate production, and 2,3-diphosphoglycerate and adenosine triphosphate ... Reduced Red Cell Glycolysis, 2,3-Diphosphoglycerate and Adenosine Triphosphate Concentration, and Increased Hemoglobin-Oxygen ...
more infohttp://annals.org/aim/article-abstract/685306/reduced-red-cell-glycolysis-2-3-diphosphoglycerate-adenosine-triphosphate-concentration
2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension | The Journal of the American...  2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension | The Journal of the American...
2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension. The Journal of the American ... Hicks J, Will D. 2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension. J Am Osteopath ... 2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension ... 2,3-Diphosphoglycerate levels of erythrocytes in hypoxia-induced bovine pulmonary hypertension ...
more infohttps://jaoa.org/article.aspx?articleid=2096792
Reduced Red Cell 2 , 3 - Diphosphoglycerate and Adenosine - Semantic Scholar  Reduced Red Cell 2 , 3 - Diphosphoglycerate and Adenosine - Semantic Scholar
A reduction in red cell ATP was also present and persisted for 5 days during which time red cell 2,3-DPG returned to levels ... A significant fall in 2,3-DPG and an increase in hemoglobin-oxygen affinity was present in red cells of patients studied on the ... The reduction in serum inorganic phosphorous followed the reduction in red cell 2,3-DPG and correlated with the reduction in ... Neither the transfusion of stored blood nor the effect of cardiopulmonary bypass fully explained the reduction in red cell 2,3- ...
more infohttps://www.semanticscholar.org/paper/Reduced-Red-Cell-2-3-Diphosphoglycerate-and-Adenos-Cohen-Murphy/82cbe210bd6c83226b3e06ce050828361d20714d
Age-Related Defects in Erythrocyte 2,3-Diphosphoglycerate Metabolism i by Yury G. Kaminsky, Prakash Reddy et al.  "Age-Related Defects in Erythrocyte 2,3-Diphosphoglycerate Metabolism i" by Yury G. Kaminsky, Prakash Reddy et al.
2,3-diphosphoglycerate (2,3-DPG) levels were significantly decreased in AD and NA patients. The pattern of changes between ... Collectively, our data suggested that AD and NA patients are associated with chronic disturbance of 2,3-DPG metabolism in RBCs ... 2,3-diphosphoglycerate (2,3-DPG) levels were significantly decreased in AD and NA patients. The pattern of changes between ... Collectively, our data suggested that AD and NA patients are associated with chronic disturbance of 2,3-DPG metabolism in RBCs ...
more infohttp://scholarsmine.mst.edu/chem_facwork/2097/
The Influence of Sodium Phosphate Supplementation on VO2max, Serum 2,3-diphosphoglycerate Level and Heart Rate in Off-road...  The Influence of Sodium Phosphate Supplementation on VO2max, Serum 2,3-diphosphoglycerate Level and Heart Rate in Off-road...
2:20-47.[PubMed] * Kreider R. B., Miller G. W., Williams M. H., Somma C. T., Nasser T. (1990) Effects of phosphate loading on ... 297(17): 901-3. * Rubin M. F., Narins R. G. (1990) Hypophosphatemia: Pathophysiological and practical aspects of its therapy. ... Cade R., Conte M., Zauner C., Mars D., Peterson J., Lunne D., Hommen N., Packer D. (1984) Effects of phosphate loading on 2,3- ... diphosphoglycerate and maximal oxygen uptake. Med Sci Sports Exerc. 16:263-268.[PubMed] ...
more infohttp://psjd.icm.edu.pl/psjd/element/bwmeta1.element.-psjd-doi-10_2478_v10078-008-0012-z
Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt...  Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt...
Hydrolysis of 2,3-BPG by human MIPP1 is sensitive to physiologic alkalosis; activity decreases 50% when pH rises from 7.0 to ... We determined that total MIPP1 activity in erythrocytes at 37 degrees C is 0.6 mmol 2,3-BPG hydrolyzed per liter of cells per h ... Our 2,3-BPG phosphatase activity is encoded by the previously identified gene for multiple inositol polyphosphate phosphatase ( ... MIPP1 is active at 4 degrees C, revealing a clinically significant contribution to 2,3-BPG loss during the storage of ...
more infohttps://www.semanticscholar.org/paper/Dephosphorylation-of-2%2C3-bisphosphoglycerate-by-the-Cho-King/e60948e6750aee5b9f5c54f1caf320a972af4f5e
2,3-Bisphosphoglyceric acid - Wikipedia  2,3-Bisphosphoglyceric acid - Wikipedia
2,3-BPG is formed from 1,3-BPG by the enzyme BPG mutase. It can then be broken down by 2,3-BPG phosphatase to form 3- ... 2,3-BPG is part of a feedback loop that can help prevent tissue hypoxia in conditions where it is most likely to occur. ... When 2,3-BPG binds to deoxyhemoglobin, it acts to stabilize the low oxygen affinity state (T state) of the oxygen carrier. It ... Its important to highlight that the behaviour of myoglobin doesnt work in the same way, as 2,3-BPG has no effect on it. In ...
more infohttps://en.wikipedia.org/wiki/2,3-Bisphosphoglyceric_acid
Table of Contents - January 24, 1975, 187 (4173) | Science  Table of Contents - January 24, 1975, 187 (4173) | Science
2,3-diphosphoglycerate: a physiological inhibitor of platelet aggregation. By SG Iatridis, PG Iatridis, SG Markidou, BH Ragatz ...
more infohttp://science.sciencemag.org/content/187/4173
WikiGenes - AmbotzHAA1166 - (2S,3R)-2-amino-3-hydroxy-butanamide  WikiGenes - AmbotzHAA1166 - (2S,3R)-2-amino-3-hydroxy-butanamide
Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. ... AmbotzHAA1166 (2S,3R)-2-amino-3-hydroxy- butanamide. Synonyms: AKOS006350428, AC1L9FO4, 49705-99-9, EINECS 256-437-4, (2S,3R)-2 ... Myotonic dystrophy (DM) results from the amplification of an unstable CTG repeat in the 3 untranslated region of a transcript ... Calcineurin is a eukaryotic Ca(2+)- and calmodulin-dependent serine/threonine protein phosphatase [14]. ...
more infohttps://www.wikigenes.org/e/chem/e/444078.html
Unit 5&6 Flashcards by Patricia Truong | Brainscape  Unit 5&6 Flashcards by Patricia Truong | Brainscape
2. ↑H+ from acids (Bohr Effect) 3. ↑H+ from CO2 (Bohr Effect) 4. ↑2,3-diphosphoglycerate (DPG) ... 1) What 2 center does Pons contain?. 2) primary or secondary respiratory center?. ...
more infohttps://www.brainscape.com/flashcards/unit-5-amp-6-2936744/packs/4590927
Sanger Institute - Publications 1993 - Wellcome Sanger Institute  Sanger Institute - Publications 1993 - Wellcome Sanger Institute
Regulation of linkages between the erythrocyte membrane and its skeleton by 2,3-diphosphoglycerate.. Moriyama R, Lombardo CR, ... Number of papers published in 1993: 3. * Yeast origin recognition complex is involved in DNA replication and transcriptional ... In addition to reducing hemoglobin-O2 affinity, 2,3-diphosphoglycerate (DPG) is known to modulate the mechanical properties of ... The inhibition was biphasic, similar to the band 3-DPG binding isotherm; however, at physiological DPG concentrations a ...
more infohttps://www.sanger.ac.uk/research/publications/1993.html
Table of Contents - February 09, 1973, 179 (4073) | Science  Table of Contents - February 09, 1973, 179 (4073) | Science
Adenosine 3,5-Monophosphate in Pancreatic Islets: Glucose-Induced Insulin Release. By M. Arthur Charles, R. Fanska, Florence ... 2, x pp. + pp. 313-612, illus. Each vol., $14.95; the set, $24.50 ... 3-Diphosphoglycerate. By E. G. Brann, D. J. Newman, Frank A. ... Oxygen Affinity in Red Cells: Inability to Show Membrane-Bound 2, ...
more infohttp://science.sciencemag.org/content/179/4073
  • The latter changes may indicate the diversion of glucose and more specifically 1,3-DPG into the RapoportLeubering pathway away from ATP generation at the phosphoglycerate kinase step and the utilization of plasma inorganic phosphate for 2,3-DPG resynthesis. (semanticscholar.org)
  • 2,3-DPG is an intermediate substrate in the glycolytic pathway, the only source of ATP production in red blood cells. (clinicaltrials.gov)
  • The 1.58 Mb genome of Ca. N. cavascurensis harbors an amo AXCB gene cluster encoding ammonia monooxygenase and genes for a 3-hydroxypropionate/4-hydroxybutyrate pathway for autotrophic carbon fixation, but also genes that indicate potential alternative energy metabolisms. (frontiersin.org)
  • The reduction in serum inorganic phosphorous followed the reduction in red cell 2,3-DPG and correlated with the reduction in ATP. (semanticscholar.org)
  • By fluorescence spectroscopy and differential scanning calorimetry, we demonstrate that DPG binds the cytoplasmic domain of erythrocyte membrane band 3 in two stages characterized by apparent KD values of approximately approximately 2 and 12 mM. (sanger.ac.uk)
  • The data demonstrated that the minimal levels of 2,3-DPG in the adult sheep are likely due to the very low levels of DPGM. (biomedsearch.com)
  • Also these findings show that the increases in 2,3-DPG levels, found in the newborn sheep during the 1st week of life, in adult rabbit and guinea pig when compared with their fetuses, are not due to an increase in levels of the DPGM. (biomedsearch.com)
  • Depence of Oxyhemoglobin Dissociation and Intraery-Throcytic 2,3-DPG on Acid-Base Status of Blood. (springer.com)
  • Neither the transfusion of stored blood nor the effect of cardiopulmonary bypass fully explained the reduction in red cell 2,3-DPG and the inefficiency of hemoglobin function postoperatively. (semanticscholar.org)
  • Each bag contains approximately 1/3 of a liter of blood and takes an estimated 3 hours to fully transfuse. (americanpregnancy.org)
  • As a significant amount of iron is removed by each autologous transfusion, an adequate time for recovery of not less than 3 days from the last donation, and appropriate iron supplements, are usually required for patients undergoing autologous donations. (wikipedia.org)
  • Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25. (semanticscholar.org)
  • It's important to highlight that the behaviour of myoglobin doesn't work in the same way, as 2,3-BPG has no effect on it. (wikipedia.org)