2,2'-Dipyridyl: A reagent used for the determination of iron.Iron Chelating Agents: Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.Chelating Agents: Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.RxNorm: A standardized nomenclature for clinical drugs and drug delivery devices. It links its names to many of the drug vocabularies commonly used in pharmacy management.Diet, Mediterranean: A diet typical of the Mediterranean region characterized by a pattern high in fruits and vegetables, EDIBLE GRAIN and bread, potatoes, poultry, beans, nuts, olive oil and fish while low in red meat and dairy and moderate in alcohol consumption.Antibiotic Prophylaxis: Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.Post-Exposure Prophylaxis: The prevention of infection or disease following exposure to a pathogen.Health Personnel: Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)Delivery of Health Care: The concept concerned with all aspects of providing and distributing health services to a patient population.Medication Systems, Hospital: Overall systems, traditional or automated, to provide medication to patients in hospitals. Elements of the system are: handling the physician's order, transcription of the order by nurse and/or pharmacist, filling the medication order, transfer to the nursing unit, and administration to the patient.Nobel PrizeEncyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Baseball: A competitive nine-member team sport including softball.LebanonEconomic Recession: Significant decline in economic activity spread across the economy, lasting more than a few months, normally visible in real gross domestic product, real income, employment, industrial production, and wholesale-retail sales. (National Bureau of Economic Research, Inc, www.nber.org/cycles.html, accessed 4/23/2009)Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)History, 20th Century: Time period from 1901 through 2000 of the common era.Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Microbial Viability: Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.Drug Discovery: The process of finding chemicals for potential therapeutic use.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Food Preservation: Procedures or techniques used to keep food from spoiling.Color: The visually perceived property of objects created by absorption or reflection of specific wavelengths of light.Clostridium botulinum: A species of anaerobic, gram-positive, rod-shaped bacteria in the family Clostridiaceae that produces proteins with characteristic neurotoxicity. It is the etiologic agent of BOTULISM in humans, wild fowl, HORSES; and CATTLE. Seven subtypes (sometimes called antigenic types, or strains) exist, each producing a different botulinum toxin (BOTULINUM TOXINS). The organism and its spores are widely distributed in nature.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Hot Temperature: Presence of warmth or heat or a temperature notably higher than an accustomed norm.Food Storage: Keeping food for later consumption.Food Microbiology: The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.Confined Spaces: A space which has limited openings for entry and exit combined with unfavorable natural ventilation such as CAVES, refrigerators, deep tunnels, pipelines, sewers, silos, tanks, vats, mines, deep trenches or pits, vaults, manholes, chimneys, etc.Occupational Diseases: Diseases caused by factors involved in one's employment.Occupational Health: The promotion and maintenance of physical and mental health in the work environment.Occupational Health Services: Health services for employees, usually provided by the employer at the place of work.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Occupational Medicine: Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Electroplating: Coating with a metal or alloy by electrolysis.Copper Sulfate: A sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.Sulfuric Acids: Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.Chlorine: A greenish-yellow, diatomic gas that is a member of the halogen family of elements. It has the atomic symbol Cl, atomic number 17, and atomic weight 70.906. It is a powerful irritant that can cause fatal pulmonary edema. Chlorine is used in manufacturing, as a reagent in synthetic chemistry, for water purification, and in the production of chlorinated lime, which is used in fabric bleaching.Nanowires: Nanometer-scale wires made of materials that conduct electricity. They can be coated with molecules such as antibodies that will bind to proteins and other substances.Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Receptors, IgE: Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).Cell Degranulation: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.Metals, Heavy: Metals with high specific gravity, typically larger than 5. They have complex spectra, form colored salts and double salts, have a low electrode potential, are mainly amphoteric, yield weak bases and weak acids, and are oxidizing or reducing agents (From Grant & Hackh's Chemical Dictionary, 5th ed)Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.
... dipyridyl disulfide and triphenylphosphine. The reaction is generally refluxed in a nonpolar solvent such as benzene. The ... 3.3.co;2-r. See the Methods tab"Compiled Works of Elias J. Corey". 2008-07-12. Retrieved 2013-11-15. Corey, E. J.; et al. (1998 ... 92 (2): 397-8. doi:10.1021/ja00705a609. PMID 5411057. For a review see Axen, U.; Pike, J. E.; and Schneider, W. P. (1973) p. 81 ... 3.0.co;2-z. Kurti, L.; Czako, B. Strategic Applications of Named Reactions in Organic Synthesis; Elsevier: Burlington, 2005. ...
... dipyridyl disulfide. As amines are good catalysts for the oxidation of thiols to disulfides, this process is autocatalytic. 2- ... dipyridyl disulfide. 2-Mercaptopyridine was originally synthesized in 1931 by heating 2-chloropyridine with calcium hydrogen ... dipyridyl disulfide. C5H4NSSC5H4N + 2H → 2HSC5H4N 2-Mercaptopyridine and the disulfide are chelating ligands. 2- ... 2-Mercaptopyridine may also be used to coat porous media in order to purify plasmid DNA of impurities such as RNA and proteins ...
Yamamoto, T.; Yamamoto, A.; Ikeda, S. (1971). "Study of Organo(dipyridyl)nickel Complexes. I. Stability and Activation of the ... 3.0.CO;2-M. Marcone, J. E.; Moloy, K. G. (1998). "Kinetic Study of Reductive Elimination from the Complexes (Diphosphine)Pd(R)( ... 2. Control of Dinuclear vs. Mononuclear Elimination of Methane from cis-Hydridomethyltetracarbonylosmium". J. Am. Chem. Soc. 99 ... Alkyl-Nickel Bonds of Dialkyl(dipyridyl)nickel by Coordination with Various Substituted Olefins". J. Am. Chem. Soc. 93: 3350. ...
It's also used in analytic chemistry in the analysis of iron in the water combinated with α,α-dipyridyl. The hydroxylammonium ... chloride transform all the iron in Fe2+, that then forms a coordination complex with the dipyridyl. Fukushima, R.S.; Dehority, ...
... dipyridyl MeSH D03.383.725.227 --- disopyramide MeSH D03.383.725.259 --- doxylamine MeSH D03.383.725.385 --- indinavir MeSH ... 2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-1h-3-benzazepin-7-ol MeSH D03.438.079.800 --- 2,3,4,5-tetrahydro-7,8-dihydroxy-1- ... quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- MeSH D03.438.834.775 --- sparteine MeSH D03.438. ... 5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole MeSH D03.383.312.649.290 --- fanft MeSH D03.383.312.649.308 --- furagin MeSH D03.383. ...
... dipyridyl coordination compound as solid reagent for spectrophotometric determination of reducing sugar employing a ... Type 2 diabetes). By measuring the amount of oxidizing agent (in this case, Fehling's solution) reduced by glucose, it is ...
... (tradenames include Ferriprox) is a drug that chelates iron and is used to treat iron overload in thalassaemia major. It was first approved for use in treating thalassaemia major in 1994 and had been licensed for use in Europe and Asia for many years while awaiting approval in Canada and the United States. On October 14, 2011, it was approved for use in the US under the FDA's accelerated approval program. Deferiprone was at the center of a protracted struggle between Nancy Olivieri, a Canadian haematologist and researcher, and the Hospital for Sick Children and the pharmaceutical company Apotex, that started in 1996 and delayed approval of the drug in North America. Olivieri's data suggested deferiprone leads to progressive hepatic fibrosis. Deferoxamine Deferasirox Savulescu, J (2004). "Thalassaemia major: The murky story of deferiprone". BMJ. 328 (7436): 358-9. doi:10.1136/bmj.328.7436.358. PMC 341373 . PMID 14962851. Staff, Cipla. Cipla's History FDA NEWS RELEASE: FDA Approves ...
... is the set of chemical reactions that maintain human homeostasis of iron at both the systemic and cellular level. The control of this necessary but potentially toxic metal is an important part of many aspects of human health and disease. Hematologists have been especially interested in systemic iron metabolism because iron is essential for red blood cells, where most of the human body's iron is contained. Understanding iron metabolism is also important for understanding diseases of iron overload, such as hereditary hemochromatosis, and iron deficiency, such as iron deficiency anemia. Iron is an essential bioelement for most forms of life, from bacteria to mammals. Its importance lies in its ability to mediate electron transfer. In the ferrous state, iron acts as an electron donor, while in the ferric state it acts as an acceptor. Thus, iron plays a vital role in the catalysis of enzymatic reactions that involve electron transfer (reduction and oxidation, redox). Proteins ...
... happens when a body has not enough (or not qualitatively enough) iron to supply its eventual needs. Iron is present in all cells in the human body and has several vital functions, such as: carrying oxygen to the tissues from the lungs as a key component of the hemoglobin protein; acting as a transport medium for electrons within the cells in the form of cytochromes; facilitating oxygen enzyme reactions in various tissues. Too little iron can interfere with these vital functions and lead to morbidity and death. Total body iron averages approximately 3.8 g in men and 2.3 g in women. In blood plasma, iron is carried tightly bound to the protein transferrin. There are several mechanisms that control human iron metabolism and safeguard against iron deficiency. The main regulatory mechanism is situated in the gastrointestinal tract. When loss of iron is not sufficiently compensated by adequate intake of iron from the diet, a state of iron deficiency develops over time. When this state ...
Mild iron deficiency can be prevented or corrected by eating iron-rich foods and by cooking in an iron skillet. Because iron is a requirement for most plants and animals, a wide range of foods provide iron. Good sources of dietary iron have heme-iron, as this is most easily absorbed and is not inhibited by medication or other dietary components. Three examples are red meat, poultry, and insects.[20][21] Non-heme sources do contain iron, though it has reduced bioavailability. Examples are lentils, beans, leafy vegetables, pistachios, tofu, fortified bread, and fortified breakfast cereals. Iron from different foods is absorbed and processed differently by the body; for instance, iron in meat (heme-iron source) is more easily absorbed than iron in grains and vegetables ("non-heme" iron sources).[22] Minerals and chemicals in one type of food may also inhibit absorption of iron from another type of food eaten at the same time.[23] For example, oxalates and phytic acid form insoluble complexes which ...
Play media In molecular biology, the iron response element or iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For example, the mRNA of ferritin (an iron storage protein) contains one IRE in its 5' UTR. When iron concentration is low, IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates. In contrast, binding to multiple IREs in the 3' UTR of the transferrin receptor (involved in iron acquisition) leads to increased mRNA stability. The two leading theories describe how iron probably interacts to impact posttranslational control of transcription. The classical theory suggests that IRPs, in the absence of iron, bind avidly to the mRNA IRE. When Iron is present, it interacts with the protein to cause it to release the mRNA. For example, In high iron conditions in humans, IRP1 ...
Treatment of the inherited blood disorder thalassemia depends upon the level of severity. For mild forms of the condition, advice and counseling are often all that are necessary. For more severe forms, treatment may consist in blood transfusion; chelation therapy to reverse iron overload, using drugs such as deferoxamine, deferiprone, or deferasirox; medication with the antioxidant indicaxanthin to prevent the breakdown of hemoglobin; or a bone marrow transplant using material from a compatible donor, or from the patient's mother. Population screening has had some success as a preventive measure. Mild thalassemia : patients with thalassemia traits do not require medical or follow-up care after the initial diagnosis is made. Patients with β-thalassemia trait should be warned that their condition can be misdiagnosed for the common Iron deficiency anemia. They should eschew empirical use of Iron therapy; yet iron deficiency can develop during pregnancy or from chronic bleeding. Counseling is ...
In ecology or geoscience, the iron cycle (Fe) is the biogeochemical cycle of iron through landforms, the atmosphere, and oceans. The iron cycle affects dust deposition and aerosol iron bioavailability. Iron ranges in oxidation states from -2 to +7; however, in Earth's crust it is predominantly in its +2 (ferrous) or +3 (ferric) redox state. The cycling of iron between its ferrous and ferric oxidation states is referred to as the iron cycle. This process can be entirely abiotic, or facilitated by microorganisms. Some examples of this include the rusting of iron-bearing metals (in this case Fe2+ is abiotically oxidized to Fe3+) by oxygen, and the abiotic reduction of Fe3+ to Fe2+ by iron-sulfide minerals. The iron cycle can also be facilitated by microorganisms, such as by Fe-oxidizing bacteria, which can oxidize Fe2+ to Fe3+, extracting one electron in the process for energy. Fe-reducing bacteria can reduce Fe3+ back to Fe2+ by utilizing it as a terminal electron acceptor. Iron is an important ...
... is an iron alloy with a very low carbon (less than 0.08%) content in contrast to cast iron (2.1% to 4%). It is a semi-fused mass of iron with fibrous slag inclusions (up to 2% by weight), which gives it a "grain" resembling wood that is visible when it is etched or bent to the point of failure. Wrought iron is tough, malleable, ductile, corrosion-resistant and easily welded. Before the development of effective methods of steelmaking and the availability of large quantities of steel, wrought iron was the most common form of malleable iron. A wrought product is one that has been mechanically worked by forging, extruding, rolling, hammering, etc., to change its form and properties. Wrought iron is a particular worked-iron product that is seldom produced today, as other cheaper, superior products are used instead. Historically, a modest amount of wrought iron was refined into steel, which was used mainly to produce swords, cutlery, chisels, axes and other edged tools as well as springs ...
The recommended iron intake for vegetarians is 180% that of nonvegetarians,[1] because plants, dairy, and eggs contain only non-heme iron, and this is absorbed less efficiently than heme iron.[20] Although a lower percentage of non-heme iron is absorbed by the body, greater total amounts of non-heme iron are concentrated in many non-meat sources of iron, and therefore breakfast cereals, eggs, nuts, seeds, and legumes (including soy foods, peas, beans, chickpeas, and lentils) are significant sources of iron,[22] and a well-planned vegetarian diet should not lead to iron deficiency, but fruitarianism and raw foods diets should not be pursued for infants or children.[1]. Meat, including fish and poultry, and not dairy or eggs, is the only source of heme iron; intake of heme iron may be associated with colon cancer.[23] Non-heme iron is more sensitive to both inhibitors and enhancers of iron absorption: Vitamin C is an iron absorption enhancer; the main inhibitors for most people are phytates (e.g. ...
... s (Greek: "iron carrier") are small, high-affinity iron-chelating compounds secreted by microorganisms such as bacteria and fungi and serving to transport iron across cell membranes. Siderophores are amongst the strongest soluble Fe3+ binding agents known. Iron is essential for almost all life for processes such as respiration and DNA synthesis. Despite being one of the most abundant elements in the Earth's crust, the bioavailability of iron in many environments such as the soil or sea is limited by the very low solubility of the Fe3+ ion. This is the predominant state of iron in aqueous, non-acidic, oxygenated environments. It accumulates in common mineral phases such as iron oxides and hydroxides (the minerals that are responsible for red and yellow soil colours) hence cannot be readily used by organisms. Microbes release siderophores to scavenge iron from these mineral phases by formation of soluble Fe3+ complexes that can be taken up by active transport mechanisms. Many ...
R. Tewari (2003) radiocarbon dated iron artefacts in Uttar Pradesh, including furnaces, tuyeres and slag between c. 1800 and 1000 BCE. Iron using and iron working was prevalent in the Central Ganga Plain and the Eastern Vindhyas from the early second millennium BCE.[3] The beginning of the use of iron has been traditionally associated with the eastward migration of the later Vedic people, who are also considered as an agency which revolutionised material culture particularly in eastern Uttar Pradesh and Bihar. Scholar Rakesh Tewari states that new finds and their dates suggest the need for a fresh review. According to him, the evidence corroborates the early use of iron in other areas of the country, and attests that India was indeed an independent centre for the development of the working of iron.[4][5]. ...
... oli alun perin rock and roll -yhtye Wolfsbanen vokalisti, mutta Bruce Dickinsonin erottua Iron Maidenin laulajan tehtävistä vuonna 1993 Bayley valittiin hänen tilalleen vuonna 1994. Hän lauloi kahdella Iron Maidenin albumilla (The X Factor vuonna 1995 ja Virtual XI vuonna 1998). Molemmat albumit saivat useimmilta levyarvostelijoilta kriittisen vastaanoton ja huonoja arvosanoja, eivätkä ne menestyneet myyntilistoilla yhtä hyvin kuin Iron Maidenin aikaisemmat albumit. Bayley itse sai ankaraa kritiikkiä monilta Iron Maidenin faneilta, koska hänen laulutekniikkansa ja matalampi lauluäänensä erosivat huomattavasti tenori Bruce Dickinsonista. Virtual XI -maailmankiertueen aikana Bayleyn lauluääni kärsi allergisista reaktioista, jotka johtuivat esiintymislavoissa käytetyistä materiaaleista. Kiertueen aikaisista ääniongelmista johtuen Bayley erotettiin Iron Maidenistä tammikuussa 1999 yhtyeen manageri Rod Smallwoodin neuvoteltua Brucen Dickisonin ja Iron Maidenin ...
பெரிக் ஆக்சலேட்டு (Ferric oxalate) என்பது C6Fe2O12 என்ற மூலக்கூற்று வாய்ப்பாடு கொண்ட ஒரு வேதிச் சேர்மம் ஆகும். பெரிக் அயனிகளும் ஆக்சலேட்டு ஈந்தணைவிகளும் சேர்ந்து உருவாகும் இச்சேர்மம், இரும்பு(III) ஆக்சலேட்டு (iron(III) oxalate) என்ற பெயராலும் அழைக்கப்படுகிறது. ஆக்சாலிக் அமிலத்தின் பெரிக் உப்பான பெரிக் ஆக்சலேட்டு வெளிர் மஞ்சள் நிறத்தில் காணப்படுகிறது. நீரேற்ற வினையின் மூலம் பெரிக் ஆக்சலேட்டை அடர் ...
... dipyridyl technical grade; CAS Number: 6153-92-0; EC Number: 228-174-5; Linear Formula: C22H16N2; find Sigma-Aldrich-366323 ...
Reagent for iron determinations.2,2-bipyridine acts as a bidentate chelating ligand which form complexes with transition metal ... 2-Bipyridine Redox Shuttle in a Non-aqueous Electrolyte. Angew. Chem. 2015, 127 (27), 7988-7992. ... 2-bipyridine-functionalized metal-organic framework MOF-253. Catal. Today 2015, 246, 55-59. ... A Photoelectrochemical Solar Cell Consisting of a Cadmium Sulfide Photoanode and a Ruthenium-2, ...
Dipyridyl Disulfide] [2127-03-9] , Buy and find out price and availability, MSDS, properties of TCIs high quality specialty ... Dipyridyl Disulfide [for Peptide Synthesis]. (CAS RN:2127-03-9 Product Number:D1114). Structure. ... dipyridyl disulfide (105 mg, 0.48 mmol) and the mixture is stirred until TLC (ethyl acetate : hexane = 2 : 3) shows complete ... 2)Facile synthesis of saturated eight-membered ring lactones *K. R. Buszek, Y. Jeong, N. Sato, P. C. Still, P. L. Muiño, I. ...
Dipyridyl Diselenide. [59957-75-4] · C10H8N2Se2 · 2,2 -Dipyridyl Diselenide · (MW 314.12) (selenoxide elimination to afford ... dipyridyl diselenide and Triphenyl Phosphite has been utilized in the synthesis of oligonucleotides (eq 5).4 This reagent has ... Dipyridyl Disulfide and Triphenylphosphine8 in that the reaction using this combination is free from undesirable byproducts. A ... Dipyridyl diselenide catalyzes the oxidation of alkenes to unsaturated ketones by Iodylbenzene (eq 6).5 The reactive species is ...
Molecular Formula: C10H8N2. Appearance: Off-white or white crystal powder. Assay (GC ): 99%min. Melting point:70-73 Moisture: ... 6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ( 7-APRA ) ... 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propionic acid HCl ... Poly(oxy-1,2-ethanediyl),a-(sulfo-1-naphthalenyl)-w-hydroxy- N, ...
The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment ... The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment ... The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment ... Drugs 2(8), 1081-5 (2001); Berns, Should the target hemoglobin for patients with chronic kidney disease treated with ...
... dipyridyl ChemIDplus 2-(2-pyridyl)pyridine ChemIDplus α,α-bipyridine NIST Chemistry WebBook ... CHEBI:30351 - 2,2-bipyridine. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... 2,2-bipyridine (CHEBI:30351) has role ligand (CHEBI:52214) 2,2-bipyridine (CHEBI:30351) is a bipyridine (CHEBI:35545) ... tris(2,2-bipyridine)ruthenium(II) (CHEBI:52931) has part 2,2-bipyridine (CHEBI:30351). tris(2,2-bipyridine)ruthenium(II) ...
estimated by Ramsays Dipyridyl Method.. [12]. Estimation of Total Iron Binding. Capacity (TIBC) done by Ramsays. Dipyridyl ... Varley H. Ramasays dipyridyl. method for total iron binding. capacity. In: Practical clinical. biochemistry 4th Ed. 1967: 475. ... Varley H. Ramasays dipyridyl. method for iron. In: Practical clinical. biochemistry 4th Ed. 1967: 472. ... approximately 2 ml blood in EDTA. (0.47mol/l K3-EDTA) container and 3 ml. blood in plain blub. The samples were. centrifuged at ...
... dipyridyl. These operons are direct targets of Fur regulation as judged by DNase I footprinting. Analyses of lacZ reporter ... that are derepressed both by mutation of fur and by treatment of cells with the iron chelator 2,2- ...
Dipyridyl / pharmacology * Ampicillin / pharmacology * Anti-Bacterial Agents / classification * Anti-Bacterial Agents / ...
2,4,4,4,-pentamethoxy triphenylmethanol, to produce a visually observable color change at the temperature being monitored. ... dipyridyl; ferric ion reacts with potassium ferrocyanide to give a blue color; magnesium ion gives a blue color with magneson; ... A known weight (e.g. 1 g) of 4BCMU [a diacetylene, R--C.tbd.C--C.tbd.C--R, where R is (CH2)4 OCONHCH2 COO(CH2)3 CH3 ] ... EXAMPLE 2. Effect of the Nature of the Matrix on the Activation Energy When the Activator and Indicator Matrices are the Same ...
2′-bipyridine ; CAS No. 142946-79-0; Photocatalysis ligand; ligand suitable for Photocatalysis, Find related products, papers, ... dipyridyl, 99.5%, purified by sublimation pricing D216305. 2,2′-Bipyridyl, ReagentPlus®, ≥99% pricing ... Empirical Formula (Hill Notation) C12H6F6N2 ...
Dipyridyl disulfide, 98%. * A14786. 3-Hydroxy-4-methoxybenzyl alcohol, 98%. * A18124. Tribromofluoromethane, 99%, stab. with ...
alpha,alpha-Dipyridyl; 2,2-Bipyridin; 2,2-Bipyridyl; 2,2-Dipyridine; 2,2-Dipyridyl; 2-(2-Pyridyl)pyridine; AA-DP; ... alpha,alpha-Dipyridyl; 2,2-Bipyridin; 2,2-Bipyridyl; 2,2-Dipyridine; 2,2-Dipyridyl; 2-(2-Pyridyl)pyridine; AA-DP; ... Pyridine is an irritant that causes CNS depression after ingestion of 1/2 cup or inhalation of 6-12 ppm; It can cause liver and ... Pyridine is an irritant that causes CNS depression after ingestion of 1/2 cup or inhalation of 6-12 ppm; It can cause liver and ...
... dipyridyl (BPy) (,99%; Aldrich), copper (II) bromide (CuBr2) (99%; Alfa Aesar), copper (II) chloride (CuCl2) (98%; Alfa Aesar ... With this model, the refractive index of the substances follows the relation of n = An + (Bn/λ2), where n is the refractive ... 2)where Ed is the energy dissipated during one oscillation, and Es is the energy stored in the oscillating system. The ... 2 Microscopic mechanism of pH response of PMETAC brushes.. (A) Changes in surface charge density (σ) and wet thickness (dwet) ...
... dipyridyl disulfide. As amines are good catalysts for the oxidation of thiols to disulfides, this process is autocatalytic. 2- ... dipyridyl disulfide. 2-Mercaptopyridine was originally synthesized in 1931 by heating 2-chloropyridine with calcium hydrogen ... dipyridyl disulfide. C5H4NSSC5H4N + 2H → 2HSC5H4N 2-Mercaptopyridine and the disulfide are chelating ligands. 2- ... 2-Mercaptopyridine may also be used to coat porous media in order to purify plasmid DNA of impurities such as RNA and proteins ...
BRENDA - The Comprehensive Enzyme Information System
... dipyridyl as for Fig. 3. (D) P. aeruginosa PAO1 (white) and ΔF1-F2 (gray) containing pPZ-bfrB (BfrB::LacZ translational fusion ... dipyridyl added to a final concentration of 300 μM; samples were taken at the times indicated and probed for sodB transcripts ... dipyridyl and/or by the iron-sparing effect of expressing the PrrF sRNAs and therefore shutting down synthesis of other iron- ... dipyridyl. Chelation could be reversed by induction of the Fur-repressed siderophores (e.g., pyoverdine) of P. aeruginosa and ...
Electrodeposition of copper in microelectronics with dipyridyl-based levelers. US20140174937 *. 24 Dic 2012. 26 Jun 2014. Rohm ... Method and composition for electrodeposition of copper in microelectronics with dipyridyl-based levelers. ... Method and composition for electrodeposition of copper in microelectronics with dipyridyl-based levelers. ... Method and composition for electrodeposition of copper in microelectronics with dipyridyl-based levelers. ...
... dipyridyl; Fe, iron(III) chloride; IgG, immunoglobulin G; mRNA, messenger RNA; RNase, ribonuclease; SD, standard deviation; WT ... dipyridyl; Fe, iron(III) chloride; IgG, immunoglobulin G; qPCR, quantitative polymerase chain reaction; SD, standard deviation. ... dipyridyl; Fe, iron(III) chloride; mRNA, messenger RNA; RNase, ribonuclease; SD, standard deviation. ... dipyridyl; Fe, iron(III) chloride; SD, standard deviation; T, time point (hours). ...
... dipyridyl (Ka = 1017.2M−1 for Fe2+); desferrioxamine mesylate (Ka = 1031 M−1 for Fe3+) (31); disodium bathocuproine ... dipyridyl (for Fe2+), desferrioxamine mesylate (for Fe3+), bathocuproine disulphonate (for Cu2+), and p-aminosalicylic acid ( ... dipyridyl (for Fe2+), desferrioxamine mesylate (for Fe3+), bathocuproine disulphonate (for Cu2+), and p-aminosalicylic acid ( ... dipyridyl and desferrioxamine mesylate for Fe, bathocuproine disulphonate for Cu, and p-aminosalicylic acid for Mn) for 2 h, ...
This invention relates to a novel 5-fluoro-2-deoxyuridine derivative and a salt thereof which have an antitumor effect on ... Family Applications (2). Application Number. Title. Priority Date. Filing Date. US06/781,988 Expired - Fee Related US4684631A ( ... 5-fluoro-2-deoxyuridine derivative and its preparation US4684631A (en) * 1984-10-09. 1987-08-04. Toyama Chemical Co., Ltd.. ... 5-fluoro-2-deoxyuridine derivative and its preparation US4684631A (en) * 1984-10-09. 1987-08-04. Toyama Chemical Co., Ltd.. ...
Purification was carried out first by reversed phase chromatography (Column: Zymor HA-Dipyridyl, 5 μm; Gradient: 10% to 100% ... R2 is -(C(R3a)(R3b))m-(C3-C6)cycloalkyl or -(C(R3a)(R3b))m- (4- to 10-membered) heterocycloalkyl having one to three ... In certain embodiments of formula Ic, R1 is hydrogen, -CH3, -CH2F, or -CH2OCH3 and R2 is -(C(R3a)(R3b))m-(C3-C6)cycloalkyl or ... LCMS m/z 296.2 [M+H+]. 1H NMR (400 MHz, CDCl3) δ 7.89-7.95 (m, 1H), 6.86-6.90 (m, 1H), 6.78 (m, 1H), 4.02 (dd, J=12.5, 2 Hz, 1H ...
... dipyridyl protected cells against UHP treatments. A mutation that produced iron overload conditions sensitized E. coli to UHP ... 1 2 3 4 5 6 7 8 9 10 , 1. Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and ... 2. Treatment of ischial pressure sores with both profunda femoris artery perforator flaps ... ... The aim of our study was to analyze which of these 2 techniques (biceps femoris myocutaneous flap vs gluteus maximus ...
3-Dipyridyl. 18.550. 97. x. Blue. 61.. Unidentified. 19.788. x. Blue. ... 2) "landscape" for wide chromatograms or "portrait" for tall chromatograms. ...
  • 2-Mercaptopyridine derivatives can also be generated from precursors lacking preformed pyridine rings. (wikipedia.org)
  • These inhibitors protect the enzyme against its full inactivation by the thiol-specific reagent Aldrithiol (2,2′-dipyridyl disulphide, DPS), suggesting that the three drugs bind to the same subsite. (mdpi.com)
  • The device operates by allowing the activating composiiton, e.g. an organic acid such as citric acid, to diffuse through the increasingly thicker composite matrix to continuously contact the indicating composition, e.g. an acid-base dye indicator such as 2,2',4,4',4",-pentamethoxy triphenylmethanol, to produce a visually observable color change at the temperature being monitored. (google.com)
  • This metal is an integral part of heme and is used as a cofactor in Fe-S proteins involved in major biological processes such as electron transport, the trichloroacetic acid (TCA) cycle, photosynthesis, N 2 fixation, gene regulation, and DNA biosynthesis ( 2 ). (asm.org)
  • The environment of the catalytic site of chymopapain A is markedly different from those of other cysteine proteinases studied to date, as evidenced by the pH-dependence of the second-order rate constant (k) for the reaction of the catalytic-site thiol group with 2,2′-dipyridyl disulphide. (biochemj.org)
  • The striking bell-shaped component that is a characteristic feature of the reactions of S-/ImH+ (thiolate/imidazolium) ion-pair components of many cysteine-proteinase catalytic sites with the 2,2′-dipyridyl disulphide univalent cation is not present in the pH-k profile for the chymopapain A reaction. (biochemj.org)
  • 2-mercaptopyridine forms the indium(III) complex In(PyS)3 complexes in supercritical carbon dioxide. (wikipedia.org)
  • Both HIF-1α and HIF-2α heterodimerize with a general bHLH/PAS partner protein, the aryl hydrocarbon receptor nuclear translocator (Arnt), to form DNA binding transcription factor complexes ( 1 , 4 , 5 ). (sciencemag.org)
  • The principle of coordination number expansion of a six coordinate homochelate, [MoO 2 (H 2 O)(BBB)] was used to prepare the complexes, which are nonelectrolytes, monomers and diamagnetic. (springer.com)
  • Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing dipyridyl ligands.Noemí Andrade-López, José G. Alvarado-Rodríguez, Simplicio González-Montiel, Carlos-Andrés Galán-Vidal, María Elena Páez-Hernández, Araceli Jiménez-Pérez, ARKIVOC (2008) 43-54. (edu.mx)
  • Crystal structures of [Pt{(C5H4N)2CH(OH)}Cl3 and [Pd{(C5H4N)2CH(2-C5H4NS)}Cl4 as DMSO solvates displayed the formation of neutral mononuclear complexes. (edu.mx)
  • The complexes were immobilized on glutathione-agarose beads for 2 h and eluted with the sample buffer by boiling. (asm.org)
  • Using a new multinucleating ligand featuring two dipyridyl alkoxide moieties and a carboxylate moiety, low symmetry tetranuclear complexes 1-M (M = Mn, Fe, and Co) have been synthesized. (caltech.edu)
  • di-2-Pyridyl ketone has been used in the preparation of unusual {Ni(II)(3)Ln(III)(μ-OR)(6)}(3+) complexes with a ″star″ topology. (fishersci.ca)
  • Its monoanionic form has been used in the synthesis of triangular Ni(2)M (M = lanthanide, Y) complexes. (fishersci.ca)
  • 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide Metho-p-toluenesulfonate, for Peptide Synthesis is among Spectrum's high quality inventory of research products from TCI America. (spectrumchemical.com)
  • A combination of 2,2 -dipyridyl diselenide and Triphenyl Phosphite has been utilized in the synthesis of oligonucleotides (eq 5). (paperplane.io)
  • Also, it has been considered that FudR is converted to 5-fluoro-2'-deoxyuridine-5'-monophosphate (commonly called FduMP) in cells, and this inhibits thymidylate synthetase and consequently inhibits DNA synthesis, whereby a carcinostatic activity is exhibited [C. Heidelberger et al. (google.com)
  • Complex 1-Mn was used as a precursor for the synthesis of a pentanuclear CaMn_4O_2 cluster (3) with the same metal stoichiometry as the biological OEC. (caltech.edu)
  • by reaction of 2-bromopyridine with Sodium Hydrogen Selenide (prepared from Selenium and Sodium Borohydride ) in ethanol followed by oxidation 1 , 4 or with Lithium Diselenide (prepared from selenium and Lithium in the presence of Diphenylacetylene as catalyst) in THF-HMPA. (paperplane.io)
  • Subsequent oxidation of the selenides to selenones and treatment with base induces the intramolecular substitution of the 2-pyridineselenonyl group by the oxygen atom of the amide to afford chiral oxazolines (eq 4). (paperplane.io)
  • 2,2 -Dipyridyl diselenide catalyzes the oxidation of alkenes to unsaturated ketones by Iodylbenzene (eq 6). (paperplane.io)
  • These Pt species have a +2 oxidation state and are stabilized by bonding with DPTZ, surface oxygen, and residual chloride from the metal precursor. (rsc.org)
  • We found that in the presence of a hydroxylic solvent, a very rapid oxidation of [dpbPtII(Me)2]- complex towards a PtIV species was observed. (umd.edu)
  • 2-Mercaptopyridine may also be used to coat porous media in order to purify plasmid DNA of impurities such as RNA and proteins at relatively quick timescales to similar methods. (wikipedia.org)
  • Fur also acts as a positive regulator and affects the production of factors [e.g., superoxide dismutase (SodB) and bacterioferritins] that can mitigate iron toxicity under iron-replete conditions, as well as nonessential proteins that contain iron (e.g., aconitase, fumarase, and succinate dehydrogenase) ( 2 , 3 ). (pnas.org)
  • Expression vectors for either the Gal4 DNA binding domain or the indicated GalDBD/hHIF-1α and /mHIF-2α CAD chimeric proteins (from human and mouse, respectively). (sciencemag.org)
  • Here, we identified secreted proteins that were differentially expressed in A. hydrophila LP-2 in response to iron starvation using an iTRAQ-based quantitative proteomics method. (frontiersin.org)
  • Fraction 5 was applied to a phenyl-Cellulofine column (1.6 by 7.5 cm), and proteins were eluted with a linear gradient (0.5 to 0 M) of (NH 4 ) 2 SO 4 at a flow rate of 30 ml h −1 . (asm.org)
  • Notable examples include nerve damage among individuals homozygous for some variants of the N-acetyltransferase 2 gene ("slow acetylators") given isoniazid as an antituberculosis therapy, hemolytic anemia among glucose 6-phosphate dehydrogenase-deficient patients given aminoquinoline antimalarial drugs, and varied rates of biotransformation of debrisoquine, an antihypertensive drug, due to genetic variation at the CYP2D6 locus. (cdc.gov)
  • The iron-regulated desA promoter was induced by addition of the iron chelating agent 2,2'-dipyridyl resulting in a strong expression of the reporter gene. (biomedcentral.com)
  • 1 Davis' download aristotles theory was three collaborative agents:( 1) leading gene( recommended groups with statistical motion),( 2) the loss of 84(6 couple, and( 3) the techniques of copper copper preventing in a sciatic organizational case. (prigsbee.com)
  • Cells were exposed to 21 or 1% O 2 for 36 h before harvest and reporter gene assays. (asm.org)
  • in which Z 1 , A, R 1 , R 2 , R 3 , m and n have the abovementioned meanings, and these are then cyclized in an inert solvent in the presence of a base and the compounds of the formula (I), (I-A) or (1-B) are optionally converted with the corresponding (i) solvents and/or (ii) bases or acids into their solvates, salts and/or solvates of the salts. (freepatentsonline.com)
  • Toxicity of dipyridyl compounds and related compounds. (nih.gov)
  • Upon screening of a chemical library comprising 2952 compounds using this strain, a compound-ethyl 2-(1-acetylpiperidine-4-carboxamido)-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carboxylate-was found to enhance the efficacy of aztreonam under iron limitation, suggesting that the compound inhibits either the iron acquisition system or the MexAB-OprM efflux pump. (mdpi.com)
  • cadmium induces intracellular accumulation of ROS by depleting intracellular glutathione, and increases nuclear Nrf-2 expression, which all lead to the upregulation of HO-1 expression. (uncg.edu)
  • Spectrophotometric determination of Fe(II) and total iron with 2,4,6-TRI(2'-pyridyl)-1,3,5-triazine in iron ores and related industrial products", 1993, 346, pp. 667-670. (patents.com)
  • Given that most microorganisms require micromolar iron concentrations for growth and multiplication [2] , the ability to obtain iron is thus an important adaptation factor requiring intricately sophisticated iron uptake systems . (prolekare.cz)
  • The importance of this strategy is evidenced by the effects of iron homeostasis disorders on both innate and acquired immune responses [2] , . (prolekare.cz)
  • Successful colonization of the human host by bacterial pathogens requires that bacteria overcome strict iron (Fe) limitations imparted by the host ( 1 , 2 ). (sciencemag.org)
  • 2) iron sulfate, but not zinc sulfate and copper sulfate, restored the upregulating effects of cadmium on HO-1 mRNA and protein expression and enzyme activity in iron-deficient cells caused by the pretreatments with iron chelators, DFO or DPD. (uncg.edu)
  • 2) being similar in effect to iron chelators, NADPH oxidase (NOX) inhibitors such as apocynin and diphenyleneiodonium (DPI), and superoxide scavenger, tiron, decreased the upregulating effects of cadmium on HO-1 mRNA and protein expression and enzyme activity. (uncg.edu)
  • Effect of bacterial consortium treated domestic waste water on seedling growth of Zea mays L. . Adv Pl Sci 2008, 21(2), 399-402. (niscair.res.in)
  • A antibiotics help to control this pathogen and prevent fish disease, but the frequent use of antibiotics might contaminate freshwater ecosystems and increase the spread of antibiotic-resistant bacterial strains ( 2 ). (frontiersin.org)
  • Drug-resistant bacterial strains are selected for immediately after initiation of antibiotic regimens, and as a consequence of continued selective pressure, very few treatment options now exist for infections caused by resistant strains of some pathogens ( 1 , 2 ). (asm.org)
  • Because B. burgdorferi is routinely grown on complex medium [Barbour-Stoenner-Kelly (BSK-II)] supplemented with 5 to 10% rabbit serum ( 14 ), it is difficult to manipulate the Fe concentration with chelators, such as 2,2′-dipyridyl (Dp) or deferoxamine mesylate (Desferal, Ds). (sciencemag.org)
  • the reaction of sodium hydrogen selenide should be carried out in a well-ventilated hood (H 2 , containing H 2 Se, is produced). (paperplane.io)
  • 7 2,2 -Dipyridyl diselenide was used in the preparation of starting selenides, for example 2-(2-pyridylseleno)cyclooctanone, by reaction with the lithium enolate of cyclooctanone (eq 1). (paperplane.io)
  • ClC5H4N + Ca(SH)2 → HSC5H4N + Ca(SH)Cl A more convenient route to 2-mercaptopyridine is the reaction of 2-chloropyridine and thiourea in ethanol and aqueous ammonia. (wikipedia.org)
  • The association constant for this reaction between mutual 2-mercaptopyridines is described below. (wikipedia.org)
  • The desA mobility shift was prevented by neutralizing DmdR with anti-DmdR antibodies or by chelating the divalent metal in the binding reaction with 2,2'-dipyridyl. (biomedcentral.com)
  • Subsequently, 2,2′-dipyridyl was withdrawn by washing the cells and changing the medium, and the cells were thereafter incubated for an additional 24 h. (asm.org)
  • The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing. (freepatentsonline.com)
  • This invention relates to a novel 5-fluoro-2'-deoxyuridine derivative and a salt thereof which have an antitumor effect on mammals, a process for producing the same, and an antitumor agent containing the same. (google.com)
  • Coordinative behavior of the di-(2-pyridyl)hydroxymethane (1) and di-(2-pyridyl)-2-pyridylsulfanylmethane (2) ligands towards Pd(II) and Pt(II) is described. (edu.mx)
  • 2-4 Genetic experiments suggest that VEGF receptor Flk-1/KDR signaling is required for proper positioning of hemangioblastic cells from the posterior primitive streak in the yolk sac. (ahajournals.org)
  • In another method, 2,2 -dipyridyl diselenide was treated with sodium borohydride to afford sodium 2-pyridineselenolate, which was used in the subsequent nucleophilic substitution reactions (eq 2). (paperplane.io)
  • Biofilm formation was higher in the presence of non-lethal high concentration of CaCl 2 , MgCl 2 , CuSO 4 , sucrose, sodium dodecyl sulfate, or dithiothreitol, and was lower in the presence of FeCl 2 or NaCl. (frontiersin.org)
  • In the Ritter-type substitution of a hydroxy group by nitriles through the anchimeric assistance of the areneselenenyl group onto the chiral carbon, chiral amides were obtained without loss of optical purity by the use of the 2-pyridineselenenyl group (eq 3), whereas racemic amides were obtained by the use of the benzeneselenenyl group. (paperplane.io)
  • and R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are each independently selected from hydrogen, alkyl of 1-8 carbon atoms, aryl, halo, and alkoxy. (patents.com)
  • Inhibitors of Fe(II)- and 2-oxoglutarate-dependent dioxygenases prevented hydroxylation of the Asn, thus allowing the CAD to interact with the p300 transcription coactivator. (sciencemag.org)
  • Full induction of HIF-1α and -2α, therefore, relies on the abrogation of both Pro and Asn hydroxylation, which during normoxia occur at the degradation and COOH-terminal transactivation domains, respectively. (sciencemag.org)
  • Disulfiram is 100 percent toxic at 2 X 10(-7) M (0.05 micrograms per ml), 23 percent toxic at 3 X 10(-7) M (0.1 microgram per ml), and 100 percent toxic again at 3.4 X 10(-6) M (1.0 microgram per ml). (worldwidescience.org)
  • Transfected HEK 293T ( A ) or PC12 ( B ) cells were left untreated or subjected to hypoxia ( 30 ) or 2,2′-dipyridyl (DP) treatment for 16 hours, then luciferase activities were measured by the dual luciferase assay (Promega). (sciencemag.org)
  • hemB codes for the single pathway enzyme, porphobilinogen synthase, that is required for heme biosynthesis ( 2 ). (asm.org)
  • The sol-gel-immobilized Tris(2,2′-bipyridyl)ruthenium(II) [Ru(bpy) 3 2+ ] electrogenerated chemiluminescence (ECL) sensor was applied to the reversed-phase high-performance liquid chromatography (HPLC) determination of phenothiazine derivatives (promazine, chlorpromazine, triflupromazine, thioridazine, and trifluoperazine) and erythromycin in human urine samples. (elsevier.com)
  • Consistent with this, N,N,N,N -tetrakis (2-pyridylmethyl) ethylenediamine significantly inhibited the FcεRI-induced degranulation and cytokine production. (jimmunol.org)
  • The hypoxia-inducible factors (HIFs) 1α and 2α are key mammalian transcription factors that exhibit dramatic increases in both protein stability and intrinsic transcriptional potency during low-oxygen stress. (sciencemag.org)
  • One important regulator in Enterobacteriaceae is the histone-like nucleoid structuring protein H-NS (for reviews, see references 2 and 10 ). (asm.org)
  • HIF is a heterodimer of HIF-α and HIF-β subunits: three distinct and nonredundant HIF-α subunits [HIF-1α, HIF-2α/EPAS1 (endothelial PAS domain protein 1), and HIF-3α], as well as three HIF-β subunits [HIF-1β/ARNT1 (aryl hydrocarbon receptor nuclear translocator 1), ARNT2, and ARNTare currently known ( Bruick and McKnight, 2002 ). (jneurosci.org)
  • The BTB-kelch protein KLEIP ( K elch- L ike E CT2 I nteracting P rotein), also known as Kelch-like protein X or KLHL20, has been identified in a yeast 2-hybrid screen using ECT2, a Rho guanine nucleotide exchange factor (RhoGEF), as bait. (ahajournals.org)
  • The enzyme showed a high dioxygenase activity only for 1,2,4-trihydroxybenzene, with K m and V max values of 9.6 μM and 6.8 μmol min −1 mg of protein −1 , respectively. (asm.org)
  • Population-based cancer records in India, which cover 3.5% of the population, indicate a crude cancer incidence rate of 6.6 per 10 000, while the crude mortality rate from cancer is estimated to be 3.8 per 10 000 [ 2]. (encognitive.com)
  • The age-adjusted incidence rates of cancer in India for the period 1980-1987 indicate that cancers of the oral cavity, pharynx, oesophagus and of the trachea and bronchus are common in males, while cancers of the genital tract, in particular the cervix and the breast, are important in females [ 2]. (encognitive.com)
  • It has been estimated by the Indian Council of Medical Research that, in India, the number of cancer patients by the year 2000 will be over 0.8 million per annum [ 2]. (encognitive.com)
  • The total number of cancer patients in India appears to be 2 million. (encognitive.com)
  • There is evidence that smoking, tobacco and betel chewing and dietary factors are important risk factors of cancer in India [ 2- (encognitive.com)
  • A few of 2-mercaptopyridine's other uses include serving as a protecting group for amines and imides as well as forming a selective reducing agent. (wikipedia.org)
  • Collectively, these observations demonstrated that NDRG1 plays an important role in mediating the inhibition effects of DpdtC in HER2-overexpressed cancer cells via selective targeting of the HER2-ERK1/2 pathway. (deepdyve.com)
  • A number of prolyl hydroxylases capable of hydroxylating HIF have been cloned ( 12 , 13 ) and are members of the Fe(II)- and 2-oxoglutarate-dependent dioxygenase superfamily ( 10 , 14 ). (sciencemag.org)
  • In addition, the characterization of a 1,2,4-trihydroxybenzene 1,2-dioxygenase from strain AK-5 is described. (asm.org)
  • 1,2,4-Trihydroxybenzene 1,2-dioxygenase activity was assayed by the method of Latus et al. (asm.org)
  • 5 The reactive species is considered to be 2-pyridineseleninic anhydride, which is much more reactive to alkenes than benzeneseleninic anhydride. (paperplane.io)
  • Here we demonstrate that two members of the SRC-1/p160 family of transcriptional coactivators harboring histone acetyltransferase activity, SRC-1 and transcription intermediary factor 2 (TIF2), are able to interact with HIF-1α and enhance its transactivation potential in a hypoxia-dependent manner. (asm.org)
  • Cells (25 g [wet weight]) of strain AK-5 were suspended in 20 mM Tris-HCl (pH 8.0) (buffer A). Cell extract (fraction 1) was prepared and treated with streptomycin sulfate (fraction 2) as described previously ( 3 ). (asm.org)
  • For both strains, graphics (right) represent percentages of cells with 1, 2, or 3-4 nuclei. (g3journal.org)
  • Paraquat and diquat are rapidly (but incompletely) absorbed from the GI tract, and peak serum levels are reached within 2 hours of ingestion. (mhmedical.com)
  • Ingestion of as little as 2-4 g, or 10-20 mL, of concentrated 20% paraquat solution has resulted in death. (mhmedical.com)
  • Over a period of 2 years, 3810 subjects attended the Centre of Nutrition which provides medical services to 0.432 million city dwellers, for the treatment of various health problems. (encognitive.com)
  • 6 . A method of copper plating for embedding fine wiring, with the copper plating solution for embedding fine wiring according to any one of claims 1 to 5 under the conditions of a cathode current density of 0.05 to 5 A/dm 2 and liquid temperature of 5 to 30 C. (google.es)
  • In the selenoxide elimination reactions to afford alkenes, the 2-pyridineseleninyl group has been reported to be a better leaving group than the benzeneseleninyl group. (paperplane.io)
  • The slightly acidic character of PCC makes it useful for cyclization reactions with alcohols and alkenes (Scheme 2). (wikipedia.org)
  • Following transfection cells were incubated either under normoxic (21% O 2 ) or hypoxic (1% O 2 ) conditions. (asm.org)
  • Pt SACs are decorated on the powder titania support, employing a metal-ligand interaction with a dipyridyl-tetrazine ligand (DPTZ). (rsc.org)
  • In this method, Ru(bpy) 3 2+ was immobilized in sol-gel-derived titania (TiO 2 )-Nafion nanocomposite films coated on a dual platinum electrode. (elsevier.com)
  • 1992 ), although others have failed to demonstrate activation of the enzyme by H 2 O 2 or by superoxide generating systems ( Lundqvist and Morgenstern, 1992 ). (aspetjournals.org)
  • 2-Mercaptopyridine was originally synthesized in 1931 by heating 2-chloropyridine with calcium hydrogen sulfide. (wikipedia.org)
  • 2-Mercaptopyridine is favored in dilute solutions and in solvents capable of hydrogen bonding. (wikipedia.org)
  • The aim of our study was to analyze which of these 2 techniques (biceps femoris myocutaneous flap vs gluteus maximus myocutaneous flap) gave the best result for ischial pressure ulcers treatment. (biomedsearch.com)
  • In addition, aromatic volatiles and all alkaloid metabolites are highly responsible for the flavor of tobacco products and chemical characteristics [2, (scirp.org)