Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Rats, Nude: A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Mice, Inbred BALB CCell Line, Tumor: A cell line derived from cultured tumor cells.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Lung Neoplasms: Tumors or cancer of the LUNG.Genetic Therapy: Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Radioimmunotherapy: Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).Cell Line: Established cell cultures that have the potential to propagate indefinitely.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Breast Neoplasms: Tumors or cancer of the human BREAST.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Thymus Gland: A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.Immunotoxins: Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Liver Neoplasms: Tumors or cancer of the LIVER.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Karyotyping: Mapping of the KARYOTYPE of a cell.Cell Growth Processes: Processes required for CELL ENLARGEMENT and CELL PROLIFERATION.Spleen: An encapsulated lymphatic organ through which venous blood filters.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Radioimmunodetection: Use of radiolabeled antibodies for diagnostic imaging of neoplasms. Antitumor antibodies are labeled with diverse radionuclides including iodine-131, iodine-123, indium-111, or technetium-99m and injected into the patient. Images are obtained by a scintillation camera.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Indium Radioisotopes: Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Tumor Stem Cell Assay: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Angiogenesis Inhibitors: Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.Rhenium: Rhenium. A metal, atomic number 75, atomic weight 186.2, symbol Re. (Dorland, 28th ed)Nudism: The practice of living unclothed for reasons of comfort or health.Radioisotopes: Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.HT29 Cells: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Heterografts: Tissues, cells or organs transplanted between animals of different species.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Genes, ras: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
In naked mole rats, this behavioral dominance occurs in the form of the queen facing the worker head-to-head, and shoving it ... link) Honeycutt, R (1992). "Naked mole-rats". Am. Scientist. 80: 43-53. Darwin, C. (1859) On the Origin of Species by Means of ... and naked mole rats depend upon tubers in the ground. Each of these resources has patchy distributions throughout the ... naked mole-rats (Heterocephalus glaber), and the insect order Hymenoptera (which includes bees, wasps, and ants). The fact that ...
Naked mole-rats went on exhibit in 1996. Komodo dragons become a feature exhibit in 1997. In 1997, zoo workers went on strike, ... The Malayan Woods Pavilion houses butterflies, whistling ducks, red-tailed green rat snakes, and clouded leopards. Opened in ... In 1998, with the amalgamation of the Metro Municipalities, the Zoo was officially renamed the Toronto Zoo. That same year, the ... the late 1970s until 1998), and white lions (1995, and again in 2012). In 1987, the zoo opened the Maya Temple exhibit and Wolf ...
Two potential examples of primitively eusocial mammals are the naked mole-rat and the Damaraland mole-rat (Heterocephalus ... Burda, H. Honeycutt; Begall, S.; Locker-Grutjen, O; Scharff, A. (2000). "Are naked and common mole-rats eusocial and if so, why ... However, a study conducted by O'Riain and Faulkes in 2008 suggests that due to regular inbreeding avoidance, mole rats ... O'Riain, M.J.; Faulkes, C. G. (2008). "African mole rats: eusociality, relatedness and ecological constraints". Ecology of ...
The longest-lived small mammals: grey squirrels (24 years), bats (30 years), and naked mole rats (32 years), all have ... Woodley, Ryan; Buffenstein, Rochelle (2002-11-01). "Thermogenic changes with chronic cold exposure in the naked mole-rat ( ... In studies where the interscapular brown adipose tissue of rats were lesioned, it was demonstrated that the rats had difficulty ... "Genome sequencing reveals insights into physiology and longevity of the naked mole rat". Nature. 479 (7372): 223-227. doi: ...
"In Praise of the African Naked Mole Rat" appeared in 2006. Oliver Rice (American poet and winner of the Theodore Roethke Prize ... in 1998) "A Writer's Guide to Canadian Literary Magazines & Journals". National Magazine Awards. 7 November 2013. Retrieved 24 ...
Two potential examples of primitively eusocial mammals are the naked mole-rat and the Damaraland mole-rat (Heterocephalus ... "Are naked and common mole-rats eusocial and if so, why?". Behavioral Ecology and Sociobiology. 47 (5): 293-303. doi:10.1007/ ... However, a study conducted by O'Riain and Faulkes in 2008 suggests that due to regular inbreeding avoidance, mole rats ... "African Mole-Rats: Eusociality, Relatedness and Ecological Constraints". Ecology of Social Evolution. Springer. pp. 207-223. ...
This is true not only to the popular social insects (ants, termites, some bees and wasps), but also for the naked mole-rat ... The hormone model of dominance and reproductive capacity has also been demonstrated in the naked mole-rat (Heterocephalus ... "Evidence that primer pheromones do not cause social suppression of reproduction in male and female naked mole-rats". Journal of ... "Dominance and queen succession in captive colonies of the eusocial naked mole-rat, Heterocephalus glaber". Proc Biol Sci. 264 ( ...
Naked DNA delivered intraportally expresses efficiently in hepatocytes. Gene Ther. 1996 Jul;3(7):593-8. 2. Budker VG, Zhang G, ... Danko I, Williams P, Wolff J. The efficient expression of intravascularly delivered DNA in rat muscle. Gene Ther 1998 5: 272- ...
Both naked mole-rats and elephants exhibit extremely low cancer rates today. Ancient DNA from the ancestors of these two ... "High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat". Nature. 499 (7458): 346-349. Bibcode: ... Aufderheide, A.C and Rodríguez-Martín, C. 1998. The Cambridge Encyclopedia of Human Paleopathology. Cambridge: Cambridge ...
... lizard Blue crane Tarantula Yellow-backed duiker Shield-tailed agama Black-and-white colobus monkeys Naked mole rats ... The Gorilla Falls Exploration Trail (formerly known as Pangani Forest Exploration Trail from August 1998 to May 2016) is a ... The attraction originally opened on April 22, 1998 as Gorilla Falls Exploration Trail, but the name was changed to Pangani ... Forest Exploration Trail in August 1998. The attraction reverted back to its original name on May 27, 2016. Okapi Spiny-tailed ...
... where it occurred with the indigenous rodents Major's tufted-tailed rat and island mouse as well as the introduced black rat ( ... The tail is longer than the head and body and appears naked for most of its length, but fine hairs are visible near the tip. ... The long tail appears mostly naked and lacks a distinct tuft, which is present in Eliurus. It differs from the eastern voalavo ... DNA sequence data suggests it may be more closely related to Grandidier's tufted-tailed rat than to other species of the ...
The Spitting Rat (1999) (read online Paul Jennings' website at the Wayback Machine (archived 17 August 2000)) Sucked In (2000) ... Maggot (2003) Deadly series (co-written with Morris Gleitzman) Nude (2000) Brats (2000) Stiff (2000) Hunt (2000) Grope (2000) ... Christian Schools' Book Award: 1998 - awarded to Paul Jennings and Jane Tanner for The Fisherman and the Theefyspray. Dymocks ... 1998 Wicked! - Winner Most Popular Oz Book; 1999 The Gizmo - Best Oz Children's Book; 2000 - No.s 1, 3, 4, 6, 7 and 10 in the ...
"Naked mole rats defy the biological law of aging". Science Magazine - AAAS. 26 January 2018. Retrieved 27 January 2018. Ruby, ... "Calico Scientists Publish Paper in eLife Demonstrating that the Naked Mole Rat's Risk of Death Does Not Increase With Age". ... Naked mole rat) do not face increased mortality risk due to aging. Many unicellular organisms age: as time passes, they divide ... "Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age". eLife. Retrieved 27 January 2018. Current ...
Festing MF, May D, Connors TA, Lovell D, Sparrow S (July 1978). "An athymic nude mutation in the rat". Nature. 274 (5669): 365- ... Biobreeding rat[edit]. Main article: Biobreeding rat. Biobreeding diabetes-prone rat (a.k.a. biobreeding rat or BBDP rat) is an ... The Sprague Dawley rat and Long-Evans rat were developed from Wistar rats. Wistar rats are more active than others like Sprague ... A laboratory rat or lab rat is a rat of the species Rattus norvegicus domestica which is bred and kept for scientific research ...
He has also been a member of alternative rock singer-songwriter Bif Naked's band. After playing in the high school punk band No ... Since then, he has also played with Air Raid Siren (featuring Rob Johnson, his former bandmate in SNFU) and Rat Silo (with ... Stubbs played with Bif Naked beginning in 1996, and frequently acted as her live drummer as well. Around this time, he also had ... Official web page Rat Silo at CBC Radio 3. ... a brief tenure with the Canadian punk band SNFU from 1998 to ...
An athymic nude mutation in the rat. Nature. 274. 365-366. Ferguson, Frederick G., et al. (1979). Three Variations of ... A laboratory rat or lab rat is a rat of the species Rattus norvegicus (brown rat) which is bred and kept for scientific ... The Sprague Dawley rat and Long-Evans rats were developed from Wistar rats. Wistar rats are more active than others like ... The spontaneously hypertensive rat and the Lewis rat are other well-known stocks developed from Wistar rats. The Long-Evans rat ...
"Naked Mole-Rat Database". Naked Mole-Rat Database 2011. Retrieved 5 July 2011. "Naked Mole-Rat Genome Resource". Naked Mole-Rat ... The naked mole-rat, the Damaraland mole-rat, and Mechow's mole-rat[citation needed] are eusocial mammals, the highest ... At lower temperatures, naked mole-rats can use behavioral thermoregulation. For example, cold naked mole-rats huddle together ... "Naked Mole Rat". Chicago Zoological Society. Retrieved 26 April 2017. Baskauf, Steve (2003). "Naked mole rat (Heterocephalus ...
These include black rhinoceros, De Brazza's monkey, hippopotamus, bontebok, naked mole-rat, reticulated giraffe, masai giraffe ... Opened in 1998, Cascade Crest is a mountain-like exhibit made mostly of basalt and features a snow cave, cirque lake, and ... The Metro Council changed the zoo's name from the Washington Park Zoo to the Oregon Zoo in April 1998. In September of that ... The zoo previously had lions, but closed the exhibit in 1998 to build Steller Cove. The three new lions come from zoos in ...
The Damaraland mole-rat is less vocal than the naked mole-rat, making only some birdlike chirps. As eusocial animals, only the ... naked mole rat, it is one of only two known eusocial mammals. Like other blesmols, the Damaraland mole-rat has a cylindrical ... The Damaraland mole-rat, Damara mole rat, or Damaraland blesmol (Fukomys damarensis) is a burrowing rodent found in southern ... It is also similar in size to most other African mole-rats, having a head-body length of 14 to 20 cm (5.5 to 7.9 in), with a ...
Amazon.com: Naked Came the Robot Paperback - 1 Nov 1988 Retrieved 2017-03-09. The Locus Index to SF Awards Bibliography at ... The Hangingstone Rat (2008 AnLab nominee) The Purloined Labradoodle (2009 AnLab nominee) Enemy Mine (Asimov's Science Fiction ... Sea of Glass (1987) ISBN 978-0595189656 Naked Came the Robot (1988) ISBN 978-0595200689 The God Box (1989) ISBN 978-0595121151 ... "The Hangingstone Rat" Analog Magazine October, 2007 "The Purloined Labradoodle" Analog Magazine January/February 2008 "Murder ...
Rat Music for Rat People, Vol. 2 (CD Presents, 1984) Millions of Dead Cops - More Dead Cops LP, 1988 (Compilation of EPs) ... MDC (Acoustic) / Naked Aggression / Raw Power / Som Hi Noise - "No More Borders", Split 7", Jailhouse/Sixty Nine Apples Records ... 1998) At War With Society II (New Red Archives, 1999) Millions of Dead Cops - Now More Than Ever LP, 2002 (Best Of Compilation ...
"Rick Gibson" on YouTube Smith, Charlie (7 February 2017). "Snffy the Rat artist plans a naked walk in downtown Vancouver". The ... He walked nude in downtown Vancouver for 11 minutes, 45.75 seconds in a light rain and a temperature of 7 degrees Celsius. " ... He told a crowd of over 300 people that he had returned the rat to the pet store where he had rented it. He encouraged the ... Gibson said he had acquired Sniffy from a pet store which sold living rats as food for snakes and lizards. The performance was ...
... the naked mole-rat and the Damaraland mole-rat. Some shrimps, such as Synalpheus regalis, are also eusocial. E. O. Wilson has ... the naked mole-rat (Heterocephalus glaber) and the Damaraland mole-rat (Fukomys damarensis), both of which are diploid and ... 1996). "A Dispersive Morph in the Naked Mole-Rat". Nature. 380 (6575): 619-621. doi:10.1038/380619a0. PMID 8602260. Williams, S ... International Union for the Study of Social Insects Eusociality in naked mole-rats. ...
This includes studies done on the aforementioned naked mole rats. In these studies, it was found that reproductive naked mole ... However, although these naked mole rats are mammalian, they are highly atypical in terms of aging studies and may not serve as ... 2013). "Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA ... Naked mole rats were found to have higher levels of superoxide dismutase, a reactive oxygen species clearing antioxidant. In ...
Although this is billed as a discography, there are two albums that follow: 1998's ...And Now Back to Our Programming and ... Swastika Rats (live) (Upright Citizens) Tube Disasters (live) (Flux of Pink Indians) Rock And Roles[30 Years](live) ( ... Naked Aggression Split' EP, 27-29 are from 'Start a Riot' compilation,. ...
Introduced rats (Rattus rattus and R. norvegicus) have become serious pests on farms, destroying stored grains.[94] ... "The Naked Scientists. Retrieved 16 July 2013.. *. Schierenbeck, Kristina A.; Lee, Carol Eunmi; Holt, Robert D. (February 26, ... Baskin, Yvonne (2003). A Plague of Rats and Rubbervines: The Growing Threat Of Species Invasions. Island Press. p. 377. ISBN ... An early human vector occurred when prehistoric humans introduced the Pacific rat (Rattus exulans) to Polynesia.[46] ...
"Naked Mole-Rat Database". Naked Mole-Rat Database 2011. Retrieved 5 July 2011. "Naked Mole-Rat Genome Resource". Naked Mole-Rat ... The naked mole-rat, the Damaraland mole-rat, and Mechows mole-rat[citation needed] are eusocial mammals, the highest ... At lower temperatures, naked mole-rats can use behavioral thermoregulation. For example, cold naked mole-rats huddle together ... "Naked Mole Rat". Chicago Zoological Society. Retrieved 26 April 2017. Baskauf, Steve (2003). "Naked mole rat (Heterocephalus ...
Jarvis, J. U. M. (1991). Reproduction of naked mole-rats. In The Biology of the Naked Mole-Rat: Monographs in Behavior and ... Growth factors affecting body size in naked mole-rats. In The Biology of the Naked Mole-Rat: Monographs in Behavior and Ecology ... Twenty-seven naked mole-rats originating from four separate colonies were used for this study. All mole-rats were adult ... Naked mole-rats are fossorial African rodents that live in large, eusocial groups. Adult subordinate female mole-rats are ...
In naked mole rats, this behavioral dominance occurs in the form of the queen facing the worker head-to-head, and shoving it ... link) Honeycutt, R (1992). "Naked mole-rats". Am. Scientist. 80: 43-53. Darwin, C. (1859) On the Origin of Species by Means of ... and naked mole rats depend upon tubers in the ground. Each of these resources has patchy distributions throughout the ... naked mole-rats (Heterocephalus glaber), and the insect order Hymenoptera (which includes bees, wasps, and ants). The fact that ...
... naked mole-rat lung fibroblasts; NMR SF, naked mole-rat skin fibroblasts; NMR SF2 Mut, mutated naked mole-rat skin fibroblast ... Naked mole-rat cells do not form a dense monolayer like the mouse cells. NMR SF, naked mole-rat skin fibroblasts; NMR LF, naked ... B) Naked mole-rat skin fibroblasts. (C) NMRSF2, a mutated line of naked mole-rat skin fibroblasts that lost early contact ... 4). Wild-type LT attenuated early contact inhibition in both naked mole-rat skin and naked mole-rat lung cells (Fig. 4 A and B ...
... an authority on African mole-rats. Jarvis had studied the ecology and physiology of naked mole-rats but at that time nothing ... Stanton Braude has been studying naked mole rats in the laboratory and field for the past 15 years. He is currently on the ... In: Sherman P, Jarvis J, Alexander RD, eds.The Biology of the Naked Mole-Rat. Princeton: Princeton University Press, 1991. p 3- ... The Predictive Power of Evolutionary Biology and the Discovery of Eusociality in the Naked Mole Rat. ...
... By SciTechDaily October 2, 2013 ... Better Protein Creation is the Key to Longevity for the Naked Mole Rat ... Be the first to comment on "Better Protein Creation is the Secret to Naked Mole Rats Longevity and Health". ... Blind Mole Rats May Hold Cellular Clues to Effective Treatments for Cancer ...
Eusociality in a mammal: cooperative breeding in naked mole-rat colonies. Science. 1981;212:571-3.CrossRefGoogle Scholar ... Naked mole rats (Heterocephalus glaber) also live in colonies with just one much larger reproductive female. Other females ... For example, honeybees, and many wasps and ants, along with the burrowing naked mole rats from Eastern Africa include ... The biology of the naked mole-rat. Princeton: Princeton University Press; 1991.Google Scholar ...
... the HIV-1 Tat protein induces apoptosis of hippocampal neurons in rats by a mechanism involving caspase activation (Kruman et ... Nuclear Trafficking of a Gadolinium Conjugate in Nude Mice Xenografted with Human LN-229 Glioma. Stefan Heckl and Ulrich Vogel ... Nuclear Trafficking of a Gadolinium Conjugate in Nude Mice Xenografted with Human LN-229 Glioma. Stefan Heckl and Ulrich Vogel ... Nuclear Trafficking of a Gadolinium Conjugate in Nude Mice Xenografted with Human LN-229 Glioma. Stefan Heckl and Ulrich Vogel ...
A huge variety of naked/free nucleic acids are being produced in the laboratory and released unregulated into the environment. ... High levels of foreign gene expression was observed in the liver cells of rats, mice and dogs when naked DNA was injected into ... Hazards of naked nucleic acids One of the key findings is that naked viral DNA is more infectious and have a wider host range ... Naked and free nucleic acids. Naked nucleic acids are DNA/RNA produced in the laboratory and intended for use in, or as the ...
Survival of naked mole-rats marked by implantable transponders and toe-clipping. J Mammal 79:360-363. doi: 10.2307/1382873 ... Abt KF, Bock WF (1998) Seasonal variations of diet composition in farmland field mice Apodemus spp. and bank voles ... Dooley J, Bowers M (1998) Demographic responses to habitat fragmentation: experimental tests at the landscape and patch scale. ...
It can be grown in continuous culture or maintained in vivo in athymic nude mice, SCID mice, or in Lewis rats. This cell line ... 8B) in rats with the pancreatic acinar carcinoma (CA20948).. FIGS. 9A-B show images of rats with the pancreatic acinar ... Imaging of Rat Pancreatic Acinar Carcinoma (AR42-J) with Bombesinate. The AR42-J cell line is derived from exocrine rat ... In this model, male Lewis rats were implanted with solid tumor material in a similar manner as described for the CA20948 rat ...
Observation of microvasculatures in athymic nude rat transplanted tumor using synchrotron radiation microangiography system. ... Microcirculation in periportal and pericentral regions of lobule in perfused rat liver. Am J Physiol 1985;249:G449-56. ... Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ... A quantitative study of fluorescein isothiocyanate-dextran transport in the microcirculation of the isolated perfused rat liver ...
This week Kat Arney has been living up to our Naked theme and exposing the truth about the weird and wonderful naked mole-rat, ... This week Kat Arney has been living up to our Naked theme and exposing the truth about the weird and wonderful naked mole-rat, ... The Naked Scientists® 2000-2016 , The Naked Scientists® and Naked Science® are registered trademarks created by Dr Chris Smith ... Looking at 37 Naked mole-rats that had died between 1998 and 2015, vets at Disneys Animal Kingdom in Florida, discovered four ...
Festing MF, May D, Connors TA, Lovell D, Sparrow S (July 1978). "An athymic nude mutation in the rat". Nature. 274 (5669): 365- ... Biobreeding rat[edit]. Main article: Biobreeding rat. Biobreeding diabetes-prone rat (a.k.a. biobreeding rat or BBDP rat) is an ... The Sprague Dawley rat and Long-Evans rat were developed from Wistar rats. Wistar rats are more active than others like Sprague ... A laboratory rat or lab rat is a rat of the species Rattus norvegicus domestica which is bred and kept for scientific research ...
Barth RF, Matalka KZ, Bailey MQ, et al A nude rat model for neutron capture therapy of human intracerebral melanoma. Int J ... tumors were established in NIH nude/nude mice by implanting 106 cells s.c. or intracerebrally by a free-hand technique into the ... Rat brain tumor models in experimental neuro-oncology: the 9L, C6, T9, F98, RG2 (D74), RT-2, and CNS-1 gliomas. J Neuro-Oncol, ... The F98 rat glioma model has been described by us in detail elsewhere (46) , and its biological behavior and lack of response ...
These mice are also athymic, and consequently homozygous nude mice lack T cells and suffer from a lack of cell-mediated ... em,Foxn1,sup,nu,/sup,,/em, (nude) mice are born with functional but faulty hair growth follicles, resulting in a hairless ... Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis. Exp Anim 47(1):63-7PubMed: 9498115 ... Also Known As: B6 nude, C57BL/6 nude. Foxn1nu (nude) mice are born with functional but faulty hair growth follicles, resulting ...
Antitumor efficacy of taxane liposomes on a human ovarian tumor xenograft in nude athymic mice. J Pharm Sci. 1995;84(12):1400- ... Pharmacokinetics of paclitaxel-containing liposomes in rats. Gerald J. Fetterly. 1,2 and Robert M. Straubinger. 1 ... The goal of this study was to determine the formulation dependence of paclitaxel pharmacokinetics in rats, in order to test the ... Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences. Cancer ...
Naked mole-rats on David Attenboroughs Natural Curiosities / Behind the scenes clip. Facultimedia. Naked mole-rats on Animal ... on naked mole-rats. Click here for Rat.systems - our website which allows you a peek into the lives of a colony of naked mole ... 3. Genomic and epigenetic approaches to understanding eusociality in naked mole-rats (In collaboration with Professor Edith ... 1987-1990: PhD "Social Suppression of Reproduction in The Naked Mole-Rat, Heterocephalus glaber". Institute of Zoology, ...
When injecting the spleen cells of the rat BMT scid mouse into nude rat, the decrease of the weight is remarkable from 3 months ... Therefore, when transplanting the bone-barrow cells of nude (rnu/rnu) rat to the scid mouse (rat BMT scid mouse), the ... XENO-GRAFT / IMMUNE STEM CELL / TYMUS / scid MOUSE / NUDE RAT / GVHD. Research Abstract. Because the lymphocyte stem cell has a ... Then, this mouse falls into GVHD after several months of the rat thymus graft and dies. At the rat BMT scid mouse, neither GVHD ...
The Damaraland mole-rat (Cryptomys damarensis) is the first eusocial mammal for which physiologically distinct castes have been ... ORiain, M. J., Jarvis, J. U. M. & Faulkes, C. G. A dispersive morph in the naked mole-rat. Nature 380, 619-621 (1996) ... In Damaraland mole-rats (Cryptomys damarensis), colony labour is divided between infrequent worker and frequent worker ... Bennett, N. C. & Faulkes, C. G. African Mole-rats Ecology and Eusociality 273 (Cambridge Univ. Press, Cambridge, 2000) ...
This is true not only to the popular social insects (ants, termites, some bees and wasps), but also for the naked mole-rat ... The hormone model of dominance and reproductive capacity has also been demonstrated in the naked mole-rat (Heterocephalus ... "Dominance and queen succession in captive colonies of the eusocial naked mole-rat, Heterocephalus glaber". Proc Biol Sci. 264 ( ... "Evidence that primer pheromones do not cause social suppression of reproduction in male and female naked mole-rats". Journal of ...
Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced ... Food intake per rat was measured to be 25-30 g/day, representing a genistein intake of 18.5-22.5 mg/rat. Assuming an oral ... These (old) control rats, however, showed significantly more staining than was seen in the control rats killed at the beginning ... The squares represent rats on the control (soy-free) diet and the diamonds represent rats on the genistein diet. ...
In a study to determine Picrorhizas potential for preventing such damage, rats were fed an extract for seven days prior to the ... Screening 20 Chinese herbs often used for clearing heat and dissipating toxin with nude mice model of hepatitis C viral ... Silymarin combats lipid peroxidation in the liver of rats and has been shown to hasten the restoration of liver cells in ... 8.Singh AK, Mani H, Seth P. "Picroliv preconditioning protects the rat liver against ischemia-reperfusion injury." Eur J ...
Are naked and common mole-rats eusocial and if so, why? Behav Ecol Sociobiol 47:293-303. de Vries GJ, Panzica GC. 2006. Sexual ... Distribution of vasopressin in the brain of the eusocial naked mole-rat. J Comp Neurol 500:1093-1105. Rosen GJ, de Vries GJ, ... The study revealed that eusocial naked mole rats exhibit a considerably greater level of OTR binding than solitary Cape mole ... Recent studies on eusocial naked mole rats have shown a possible relation between sociality and OT-immunoreactive (OT-ir) ...
Scharrer, E. et al., "Stimulation of mucosal uptake of selenium from selenite by some thiols at various sites of rat intestine ... Yunmbam, M.K., "Inhibition of breast cancer in nude mouse model by anti-angiogenesis," Oncol. Rep., 5(6): 1431-7, abstract (Nov ... Van Der Kraan, P.M. et al., "The Effect of Chronic Paracetamol Adminstration to Rats on the Glycosaminoglycan Content of ... Van der Kraan, P.M. et al., "The Effect of Chronic Paracetamol Administration to Rats on the Glycosaminoglycan Content of ...
  • 2000) studied skin absorption and penetration of JP-8 and its components in an in vitro system using rat skin. (cdc.gov)
  • The naked mole-rat, the Damaraland mole-rat, and Mechow's mole-rat[citation needed] are eusocial mammals, the highest classification of sociality. (wikipedia.org)
  • The skin of naked mole-rats lacks a key neurotransmitter called substance P that is responsible in mammals for sending pain signals to the central nervous system. (wikipedia.org)
  • The African mole-rats (Family: Bathyergidae) are extraordinary among mammals in the diversity and range of social strategies adopted by the member species. (qmul.ac.uk)
  • In order to extend our comparison and to evaluate the possible conservation of this pattern in Mammals, in the present work we have studied the correlation between PTMA and the meiotic and post-meiotic phases of rat spermatogenesis. (unipd.it)
  • We propose that the additional layer of protection conferred by two-tiered contact inhibition contributes to the remarkable tumor resistance of the naked mole-rat. (pnas.org)
  • However, β 4 does not play a direct role in regulating the proliferative capacity of rat mammary tumor cells. (aacrjournals.org)
  • Improved perfusion MR imaging assessment of intracerebral tumor blood volume and antiangiogenic therapy efficacy in a rat model with ferumoxytol. (healthtap.com)
  • Dynamic magnetic resonance imaging assessment of vascular targeting agent effects in rat intracerebral tumor models. (healthtap.com)
  • Preclinical Antitumor Efficacy of S-1: A New Oral Formulation of 5-Fluorouracil on Human Tumor Xenografts," International Journal of Oncology, Vol. 13, No. 4, 1998, pp. 693-698. (scirp.org)
  • Tumor-selective delivery of doxorubicin by a prostate-specific antigen (PSA)-targeted peptide conjugate prodrug of doxorubicin was demonstrated in a nude mouse xenograft model of human prostate cancer. (aspetjournals.org)
  • and it is possible that female mole-rats make a significant physical transformation after removal from reproductive suppression: a time when puberty-like hormonal changes may be occurring. (biologists.org)
  • Recent studies revealed that the cells of Naked mole-rats make a sticky substance called hyaluronan, which is thought to stop tumours in their tracks. (thenakedscientists.com)
  • Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences. (pubmedcentralcanada.ca)
  • Baliga R, Zhang Z, Baliga M, Ueda N, Shah SV (1998) In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity. (springer.com)
  • And though analysts have yet to offer their forecasts for the field, insiders often cite a 1998 report from the European Network of Excellence in Multi-functional Microsystems (an industry consortium funded by the European Union) predicting a worldwide market of $1 billion for microfabricated drug-delivery devices by 2002. (technologyreview.com)
  • In the present investigation, we examined the changes that occur to the spinal column of female naked mole-rats when they are released from the reproductive suppression of the colony queen. (biologists.org)
  • Comparing Deficits Following Excitotoxic and Contusion Injuries in the Thoracic and Lumbar Spinal Cord of the Adult Rat (1998) Magnuson David S.K et al. (naver.com)
  • Brain-Derived Neurotrophic Factor Stimulates Hindlimb Stepping and Sprouting of Cholinergic Fibers after Spinal Cord Injury (1998) Jakeman Lyn B et al. (naver.com)
  • Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat. (naver.com)
  • Temporal kinetics of macrophage polarization in the injured rat spinal cord. (naver.com)
  • In studies, silymarin and silibinin actually elevated glutathione levels in rats given alcohol. (jonbarron.org)
  • Tamoxifen, a partial estrogen antagonist in humans, is used widely in the treatment of breast cancer and suppresses growth hormone plasma levels in rats up to seven weeks after treatment. (ubc.ca)
  • Our results show that IL-24 suppresses the growth of rat mammary carcinoma cells and may play a role in the resistance of Copenhagen rats to mammary carcinogenesis. (aacrjournals.org)
  • We hypothesized that our anchorage-dependent and anchorage-independent cell lines may recapitulate the resistance and susceptibility of Copenhagen and Wistar-Furth rats, respectively, to mammary carcinogenesis that could facilitate the identification of breast cancer susceptibility genes. (aacrjournals.org)
  • Jarvis, J. U. M. & Bennett, N. C. Eusociality has evolved independently in two genera of bathyergid mole-rats-but occurs in no other subterranean mammal. (nature.com)
  • Burland, T. M., Bennett, N. C., Jarvis, J. U. M. & Faulkes, C. G. Eusociality in African mole-rats: new insights from patterns of genetic relatedness in the Damaraland mole-rat. (nature.com)
  • The genetics of rats was studied by William Ernest Castle at the Bussey Institute of Harvard University until it closed in 1994. (wikipedia.org)
  • Therefore, when transplanting the bone-barrow cells of nude (rnu/rnu) rat to the scid mouse (rat BMT scid mouse), the lymphocytes of the donor origin immigrate into the thymus. (nii.ac.jp)
  • Then, this mouse falls into GVHD after several months of the rat thymus graft and dies. (nii.ac.jp)
  • The rat BMT scid mouse is the model which is extremely useful to study education effects to the T cell of the thymus. (nii.ac.jp)
  • Prothymosin-α (PTMA) is a small, highly acidic protein, first studied in the rat thymus as an immunogenic factor (Haritos et al. (unipd.it)
  • In the laboratory we can transform subordinate female mole-rats into reproductively viable animals by removing them from the colony and housing them with a male. (biologists.org)
  • In the present investigation, we examined a growth phase in female mole-rats that occurs after separation from the colony queen in the absence of pregnancy and corresponding to a puberty-like phase. (biologists.org)
  • The first rat colony in America used for nutrition research was started in January 1908 by Elmer McCollum , and then nutritive requirements of rats were used by Thomas Burr Osborne and Lafayette Mendel to determine the details of protein nutrition . (wikipedia.org)
  • In Damaraland mole-rats ( Cryptomys damarensis ), colony labour is divided between 'infrequent worker' and 'frequent worker' castes 2 . (nature.com)
  • BD) linked to epidermal growth factor (EGF) for neutron capture therapy in rats bearing a syngeneic epidermal growth factor receptor (EGFR) + glioma. (aacrjournals.org)
  • Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determination. (healthtap.com)
  • The Origins of Virtue searches for the roots of that capacity for trust, contrasts it with the social instincts of ants, baboons, and naked mole rats, and draws provocative conclusions for our understanding of politics. (ebay.com.au)
  • 1995. The nude mutation results in impaired primary antibody repertoire. (jax.org)
  • 1995. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. (jax.org)
  • Recent investigations associated with gene therapy and vaccines leave little doubt that naked and free nucleic acids are readily taken up by the cells of all species including human beings, and may become integrated into the cell s genetic material. (i-sis.org.uk)
  • Naked nucleic acids are DNA/RNA produced in the laboratory and intended for use in, or as the result of genetic engineering (1). (i-sis.org.uk)
  • The constructs typically contain antibiotic resistance marker genes plus a heterogeneous array of genes from pathogenic bacteria, viruses and other genetic parasites belonging to practically every kingdom of living organisms on earth (2).Most of the naked nucleic acids and constructs have either never existed in nature, or if they have, not in such large amounts. (i-sis.org.uk)
  • Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012, showed that the albino rats descended from hooded rats and all the albino rats descended from a single ancestor. (wikipedia.org)
  • Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis. (jax.org)
  • The goal of this study was to determine the formulation dependence of paclitaxel pharmacokinetics in rats, in order to test the hypothesis that altered biodistribution of paclitaxel modifies the exposure of critical normal tissues. (pubmedcentralcanada.ca)
  • Alternatively, the effects could have been caused by a residual tamoxifen metabolite that remained in rat tissues at concentrations below the limits of quantitation of the HPLC assay. (ubc.ca)
  • Data on oral absorption of jet fuels and related substances are limited, but suggest that these substances are absorbed from the gastrointestinal tract (ATSDR 1995a, 1995b, 1998). (cdc.gov)
  • Andreyev HJ, Norman AR, Oates J et al (1998) Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? (springer.com)
  • The albino laboratory rat with its red eyes and white fur is an iconic model organism for scientific research in a variety of fields. (wikipedia.org)
  • A laboratory rat or lab rat is a rat of the species Rattus norvegicus domestica which is bred and kept for scientific research. (wikipedia.org)
  • Over the next 30 years rats were used for several more experiments and eventually the laboratory rat became the first animal domesticated for purely scientific reasons. (wikipedia.org)
  • 2013). "Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat. (evolverzone.com)
  • Silymarin combats lipid peroxidation in the liver of rats and has been shown to hasten the restoration of liver cells in damaged liver tissue. (jonbarron.org)
  • The mechanisms responsible for the cancer resistance of naked mole-rats were unknown. (pnas.org)
  • ii) the mechanisms underlying socially-induced reproductive suppression, whereby in naked mole-rats, social cues may cause the gonads of fully grown adults to be held in a potentially permanent, but reversible pre-pubertal state. (qmul.ac.uk)
  • The mechanisms of whisking in the rat, and hypotheses concerning biomechanical interactions during whisking, are discussed with respect to the muscle architecC 2010 ture of the rat mystacial pad. (docme.ru)
  • Adult subordinate female mole-rats are reproductively suppressed by the dominant breeding female in their colonies. (biologists.org)
  • The reporter gene pEGFP-C1(25g/5μl) was injected in the striatum of young adult rats and various ranges of square electrical impulses were applied by using a pair of electrodes that were placed in the striatum. (nii.ac.jp)
  • Two different type of cerebral ischemia has been prepared in host adult rats. (nii.ac.jp)
  • Identification of MHC class Ib ligands for stimulatory and inhibitory Ly49 receptors and induction of potent NK cell alloresponses in rats. (uio.no)
  • Early studies indicate that rats may have a repertoire of MHC class Ib-reactive Ly49 stimulatory receptors capable of mounting memory-like NK cell alloresponses. (uio.no)
  • Boronated EGF was radiolabeled with 125 I and administered by CED at a rate of 0.33 μl/min for 15, 30, and 60 min [infusion volumes (V I ) of 5, 10, and 20 μl, respectively], using a syringe pump connected to an indwelling cannula implanted into the right caudate nucleus of normal rats or i.t. in rats bearing either F98 EGFR or F98 wild-type (F98 WT ) gliomas. (aacrjournals.org)
  • Scientists have bred many strains or "lines" of rats specifically for experimentation. (wikipedia.org)
  • Molteno, A. J. & Bennett, N. C. Relaxation of socially-induced reproductive inhibition in colonies of the eusocial Damaraland mole-rat: the effect of aridity as an ecological constraint promoting philopatry. (nature.com)
  • To investigate whether sheets of retina organoids derived from human embryonic stem cells (hESCs) can differentiate, integrate, and improve visual function in an immunodeficient rat model of severe retinal degeneration (RD). (arvojournals.org)
  • After transplantation into an immunodeficient rat model of severe RD, the transplanted sheets differentiated, integrated, and produced functional photoreceptors and other retinal cells, according to the longer human developmental timetable. (arvojournals.org)
  • On the other hand, when transplanting the thymic lobes of the 15th of embryonic rats under the kidney capsule of scid mouse, the lobes grow. (nii.ac.jp)
  • After housing subordinate female mole-rats separately from their home colonies, these animals experienced a growth surge that dramatically increased their body mass and length. (biologists.org)
  • Furthermore, we show that a combination of activated Ras and SV40 LT fails to induce robust anchorage-independent growth in naked mole-rat cells, while it readily transforms mouse fibroblasts. (pnas.org)
  • In cell culture, naked mole-rat fibroblasts arrest at a much lower density than those from a mouse. (pnas.org)
  • These evidences show that the immune system of rat origin can grow sufficiently in the scid mouse. (nii.ac.jp)
  • At the rat BMT scid mouse, neither GVHD nor localized autoimmune diseases developed and the long-range survival is possible. (nii.ac.jp)
  • We gave the rat BMT scid mouse a foreign antigen (SRBC) and examined immune function but the reaction was very weak. (nii.ac.jp)
  • This phenomenon is peculiar, because both the expression patterns of TCR of T cells and IgG of B cells in rat BMT scid mouse are as those of normal rat. (nii.ac.jp)
  • When injecting the spleen cells of the rat BMT scid mouse into nude rat, the decrease of the weight is remarkable from 3 months to 5 months after the treatment and the GVHD-like disease occurred. (nii.ac.jp)
  • Laboratory rats are frequently subject to dissection or microdialysis to study internal effects on organs and the brain, such as for cancer or pharmacological research. (wikipedia.org)
  • Distribution of Oxytocin- and Vasopressin-Immunoreactive Neurons in the Brain of the Eusocial Mole Rat (Fukomys anselli). (docme.ru)