Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Helicobacter: A genus of gram-negative, spiral-shaped bacteria that has been isolated from the intestinal tract of mammals, including humans. It has been associated with PEPTIC ULCER.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Urease: An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 188.8.131.52.Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Dyspepsia: Impaired digestion, especially after eating.Anti-Ulcer Agents: Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Bacterial Proteins: Proteins found in any species of bacterium.Stomach Neoplasms: Tumors or cancer of the STOMACH.Stomach Diseases: Pathological processes involving the STOMACH.Gastritis, Atrophic: GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.Bismuth: A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.Pyloric Antrum: The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS).Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Duodenal Ulcer: A PEPTIC ULCER located in the DUODENUM.Breath Tests: Any tests done on exhaled air.Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Helicobacter hepaticus: A species of HELICOBACTER that colonizes the CECUM and COLON of several strains of MICE, and is associated with HEPATITIS and carcinogenesis.Gastroscopy: Endoscopic examination, therapy or surgery of the interior of the stomach.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Helicobacter heilmannii: A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.2-Pyridinylmethylsulfinylbenzimidazoles: Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.Proton Pump Inhibitors: Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Tinidazole: A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.Lewis Blood-Group System: A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Pepsinogen A: This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Endoscopy, Gastrointestinal: Endoscopic examination, therapy or surgery of the gastrointestinal tract.Duodenitis: Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.Furazolidone: A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)Gerbillinae: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Cytotoxins: Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.Gastrins: A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Gastric Acid: Hydrochloric acid present in GASTRIC JUICE.Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.Pepsinogens: Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.Antacids: Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.Pepsinogen C: This is one of the 2 related pepsinogen systems in humans. It is found in prostate and seminal fluid whereas PEPSINOGEN A is not.Antitrichomonal Agents: Agents used to treat trichomonas infections.Nitroreductases: Enzymes which reduce nitro groups (NITRO COMPOUNDS) and other nitrogenous compounds.Penicillins: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Pylorus: The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Genes, Bacterial: The functional hereditary units of BACTERIA.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.Virulence Factors: Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)Gastric Mucins: Mucins that are found on the surface of the gastric epithelium. They play a role in protecting the epithelial layer from mechanical and chemical damage.Gastric Juice: The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Sulfoxides: Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)Endoscopy, Digestive System: Endoscopic examination, therapy or surgery of the digestive tract.Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Antigens, CD15: A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.Seroepidemiologic Studies: EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.Parietal Cells, Gastric: Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.Adhesins, Bacterial: Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Genomic Islands: Distinct units in some bacterial, bacteriophage or plasmid GENOMES that are types of MOBILE GENETIC ELEMENTS. Encoded in them are a variety of fitness conferring genes, such as VIRULENCE FACTORS (in "pathogenicity islands or islets"), ANTIBIOTIC RESISTANCE genes, or genes required for SYMBIOSIS (in "symbiosis islands or islets"). They range in size from 10 - 500 kilobases, and their GC CONTENT and CODON usage differ from the rest of the genome. They typically contain an INTEGRASE gene, although in some cases this gene has been deleted resulting in "anchored genomic islands".Peptic Ulcer Hemorrhage: Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).RNA, Ribosomal, 23S: Constituent of 50S subunit of prokaryotic ribosomes containing about 3200 nucleotides. 23S rRNA is involved in the initiation of polypeptide synthesis.Azure Stains: PHENOTHIAZINES with an amino group at the 3-position that are green crystals or powder. They are used as biological stains.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Campylobacter: A genus of bacteria found in the reproductive organs, intestinal tract, and oral cavity of animals and man. Some species are pathogenic.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Endoscopy: Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.Colony Count, Microbial: Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.Serologic Tests: Diagnostic procedures involving immunoglobulin reactions.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Histamine H2 Antagonists: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Esophagitis: INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.Gastric Acidity Determination: Gastric analysis for determination of free acid or total acid.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Bacterial Vaccines: Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Esophagitis, Peptic: INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.Vacuoles: Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion.Levofloxacin: The L-isomer of Ofloxacin.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.ColombiaDuodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Bacterial Outer Membrane Proteins: Proteins isolated from the outer membrane of Gram-negative bacteria.Esomeprazole: The S-isomer of omeprazole.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.RNA, Bacterial: Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.Cardia: That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).Bacterial Toxins: Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.Helicobacter felis: A species of HELICOBACTER that colonizes in the STOMACH of laboratory MICE; CATS; and DOGS. It is associated with lymphoid follicular hyperplasia and mild GASTRITIS in CATS.Transformation, Bacterial: The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.BulgariaRisk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Flagellin: A protein with a molecular weight of 40,000 isolated from bacterial flagella. At appropriate pH and salt concentration, three flagellin monomers can spontaneously reaggregate to form structures which appear identical to intact flagella.Bacteriological Techniques: Techniques used in studying bacteria.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
It is especially useful in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis, where ... Duodenal Release Ferrous Glycine Sulfate in Iron Deficiency Anemia Associated with Autoimmune Gastritis and Helicobacter pylori ... doi:10.1016/s0271-5317(00)00215-3. Aronstam, A.; Aston, D. (1982). "A comparative trial of a controlled-release iron tablet ...
helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to ... Takahashi, T.; Yujiri, T.; Tanizawa, Y. (2004). "Helicobacter pylori and chronic ITP: the discrepancy in the clinical responses ... 9 December 1982). "Chronic immune thrombocytopenic purpura in monozygotic twins: genetic factors predisposing to ITP". New ...
City of Adelaide
Discovered role of Helicobacter pylori in gastric ulcers Shaun Micallef - Actor and host of Talking About Your Generation Frank ... In 1982 the Council approved the design of the Armorial Flag. In 2015, the Council became the first government of any kind in ... Japan since 1982 Austin, Texas, USA since 1983 Dalian, Liaoning, China since 2001 Chengdu, Sichuan, China since 2001 Qingdao, ... Shandong, China since 2013 The armorial flag of Adelaide, was approved on 2 August 1982. William Bragg - Nobel Laureate of ...
Peptic ulcer disease
H. pylori. Helicobacter pylori is one of the major causative factors of peptic ulcer disease. It secretes urease to ... Helicobacter pylori was identified in 1982 by two Australian scientists, Robin Warren and Barry J. Marshall, as a causative ... Helicobacter pylori, non-steroidal anti-inflammatory drugs, tobacco smoking, Crohn disease. ... Common causes include the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). Other, less ...
Such salts have been shown to inhibit proliferation of Helicobacter pylori, other enteric bacteria, and some fungi. Bismuth ... Norwich Eaton Pharmaceuticals was acquired by Procter and Gamble in 1982. As of 1946, Canadian advertisements placed by Norwich ... Wesołowski, M. (1982). "Thermal decomposition of pharmaceutical preparations containing inorganic components". Microchimica ...
Blanchard, T G; Nedrud, J G (2010). "9. Helicobacter pylori Vaccines". In Sutton, Philip; Mitchell, Hazel. Helicobacter Pylori ... "Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and ... "European Helicobacter Pylori Study Group (EHPSG). Current concepts in the management of Helicobacter pylori infection-the ... pylori from the National Institutes of Health European Helicobacter Study Group (EHSG) Type strain of Helicobacter pylori at ...
Budzyński J, Kłopocka M (2014). "Brain-gut axis in the pathogenesis of Helicobacter pylori infection". World J. Gastroenterol. ... In digestive tissue, H. pylori can alter signaling in the brain-gut axis by mast cells, the main brain-gut axis effector ... Machen TE, Rutten MJ, Ekblad EB (February 1982). "Histamine, cAMP, and activation of piglet gastric mucosa". The American ...
Timeline of peptic ulcer disease and Helicobacter pylori
Unge, Peter (2002). "Helicobacter pylori treatment in the past and in the 21st century". In Barry Marshall. Helicobacter ... Mozorov, Igor A., "Helicobacter pylori was discovered in Russia in 1974", in Helicobacter Pioneers, pp. 105-118. Freedberg, A. ... Steer, Howard W (2002). "The discovery of Helicobacter pylori in England in the 1970s". In Barry J. Marshall. Helicobacter ... Fukuda, Yoshihiro et al., "Kasai, Kobayashi and Koch's postulates in the history of Helicobacter pylori", in Helicobacter ...
Marshall and Robin Warren showed that the bacterium Helicobacter pylori (H. pylori) plays a major role in causing many peptic ... Nobelprize.org bio The Helicobacter Foundation Discussion Pages The Helicobacter pylori Research Laboratory The Helicobacter ... Timeline of peptic ulcer disease and Helicobacter pylori Marshall, Prof. Barry James. ukwhoswho.com. Who's Who. 2015 (online ... This discovery has allowed for a breakthrough in understanding a causative link between Helicobacter pylori infection and ...
The urea breath test for helicobacter pylori commonly used a dose of 14C labeled urea to detect h. pylori infection. If the ... Peeters, M (1998). "Urea breath test: a diagnostic tool in the management of Helicobacter pylori-related gastrointestinal ... 1982. L. L. Lucas; M. P. Unterweger (2000). "Comprehensive Review and Critical Evaluation of the Half-Life of Tritium" (PDF). ... labeled urea was metabolized by h. pylori in the stomach, the patient's breath would contain labeled carbon dioxide. In recent ...
ಜಠರ/ಜಠರೀಯ ಹುಣ್ಣು/ವ್ರಣ - ವಿಕಿಪೀಡಿಯ
2003). "Stress, but not Helicobacter pylori, is associated with peptic ulcer disease in a Thai population". J Med Assoc Thai. ... See also: Timeline of peptic ulcer disease and Helicobacter pylori. ಈ ರೋಗಕ್ಕೆ ಸೂಕ್ಷ್ಮಜೀವಿಗಳೇ ಪ್ರಮುಖ ಕಾರಣ ಎಂದು ತಿಳಿದುಬರುವ ... 2002). "Long-term stress and Helicobacter pylori infection independently induce gastric mucosal lesions in C57BL/6 mice". Scand ... Helicobacter pylori, and Smoking". Journal of Clinical Gastroenterology. 24 (1): 2-17. PMID 9013343. Retrieved 2010-03-18.. ...
Helicobacter pylori bahasa Indonesia, ensiklopedia bebas
Helicobacter pylori, yang sebelumnya disebut Campylobacter pylori, adalah sebuah bakteri mikroaerofil Gram-negatif yang ... a b Brown LM (2000). "Helicobacter pylori: epidemiology and routes of transmission" (PDF). Epidemiol Rev 22 (2): 283-97. PMID ... Yamaoka, Yoshio (2008). Helicobacter pylori: Molecular Genetics and Cellular Biology. Caister Academic Pr. ISBN 1-904455-31-X. ... Suerbaum S, Michetti P (October 2002). "Helicobacter pylori infection". N. Engl. J. Med. 347 (15): 1175-86. PMID 12374879. doi: ...
See also: Timeline of peptic ulcer disease and Helicobacter pylori. Helicobacter pylori migrated out of Africa along with its ... Helicobacter pylori Vaccines". In Sutton, Philip; Mitchell, Hazel. Helicobacter Pylori in the 21st Century. Mitchell, Hazel. ... "Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and ... "European Helicobacter Pylori Study Group (EHPSG). Current concepts in the management of Helicobacter pylori infection-the ...
Stevenson TH, Castillo A, Lucia LM, Acuff GR (2000). "Growth of Helicobacter pylori in various liquid and plating media". Lett ... Helicobacter pylori, Klebsiella pneumoniae, Legionella pneumophila, Neisseria gonorrhoeae, Neisseria meningitides, ... Heise E (1982). "Diseases associated with immunosuppression". Environ Health Perspect. 43: 9-19. doi:10.2307/3429162. JSTOR ...
Sensitivity of Helicobacter pylori to an innate defence mechanism, the lactoperoxidase system, in buffer and in human whole ... darunter auch mikroaerophile Helicobacter pylori. Der Effekt des Lactoperoxidase-Systems hängt von bestimmten ... 3, Februar 1982, S. 562-7. doi:10.1021/bi00532a023. PMID 7066307. *↑ Thomas EL, Aune TM: Lactoperoxidase, peroxide, thiocyanate ...
In Helicobacter pylori, ciprofloxacin, which interacts with DNA gyrase and introduces double-strand breaks, induces expression ... Transformation has been studied in medically important Gram-negative bacteria species such as Helicobacter pylori, Legionella ... "DNA damage triggers genetic exchange in Helicobacter pylori". PLoS Pathogens. 6 (7): e1001026. doi:10.1371/journal.ppat.1001026 ... and Helicobacter pylori (class epsilon) "Transformation" may also be used to describe the insertion of new genetic material ...
Risk factors include poor immune function, autoimmune diseases, Helicobacter pylori infection, hepatitis C, obesity, and ... associated with adult T-cell lymphoma Helicobacter pylori: associated with gastric lymphoma HHV-8: associated with primary ... Following its publication in 1982, the Working Formulation became the standard classification for this group of diseases. It ...
Haukioja A, Ihalin R, Loimaranta V, Lenander M, Tenovuo J (September 2004). "Sensitivity of Helicobacter pylori to an innate ... The lactoperoxidase system efficiently inhibits helicobacter pylori in buffer; however, in whole human saliva, it has a weaker ... Wever R, Kast WM, Kasinoedin JH, Boelens R (December 1982). "The peroxidation of thiocyanate catalysed by myeloperoxidase and ... Pruitt KM, Tenovuo J, Andrews RW, McKane T (February 1982). "Lactoperoxidase-catalyzed oxidation of thiocyanate: polarographic ...
Barry Marshall - Vikipedi
Marshall çoğu peptik ülser hastalığının ana nedeninin Helicobacter pylori (H. pylori) bakterisi olduğunu göstermesiyle bilinir ... "Sydney Morning Herald Features Barry Marshall Helicobacter pylori". Vianet.net.au. 1997-08-02. 18 Temmuz 2014 tarihinde ... Peptik ülser hastalığı ve Helicobacter pylori'nin zaman çizelgesi Kaynakça[değiştir , kaynağı değiştir]. *^ "U.Va. Top News ... "Barry Marshall Interview, H. Pylori and the Making of a Myth". Academy of Achievement. 23 May 1998. 26 Haziran 2015 tarihinde ...
Formyl peptide receptor 1
"Basophils infiltrate human gastric mucosa at sites of Helicobacter pylori infection, and exhibit chemotaxis in response to H. ... pylori-derived peptide Hp(2-20)". Journal of Immunology. 172 (12): 7734-43. doi:10.4049/jimmunol.172.12.7734. PMID 15187157. ... Jesaitis AJ, Naemura JR, Painter RG, Sklar LA, Cochrane CG (Dec 1982). "Intracellular localization of N-formyl chemotactic ...
"Brain-gut axis in the pathogenesis of Helicobacter pylori infection". World J. Gastroenterol. 20 (18): 5212-25. doi:10.3748/wjg ... In digestive tissue, H. pylori can alter signaling in the brain-gut axis by mast cells, the main brain-gut axis effector. CS1 ... Machen TE, Rutten MJ, Ekblad EB (februar 1982). "Histamine, cAMP, and activation of piglet gastric mucosa". The American ...
வயிற்றுப் புண் - தமிழ் விக்கிப்பீடியா
Kim YH, Lee JH, Lee SS, et al. (2002). "Long-term stress and Helicobacter pylori infection independently induce gastric mucosal ... Wachirawat W, Hanucharurnkul S, Suriyawongpaisal P, et al. (2003). "Stress, but not Helicobacter pylori, is associated with ... "Mastic gum has no effect on Helicobacter pylori load in vivo". J. Antimicrob. Chemother. 52 (3): 522-3. doi:10.1093/jac/dkg366 ... "Mastic gum kills Helicobacter pylori [Letter to the editor, not a peer-reviewed scientific article"]. N. Engl. J. Med. 339 (26 ...
List of Nobel Prize winners in Physiology or Medicine - Simple English Wikipedia, the free encyclopedia
2005 - Barry Marshall and Robin Warren, Australia, for finding the bacterium Helicobacter pylori that causes gastritis and ... 1982 - Sune Bergström, Bengt I. Samuelsson, Sweden, and John R. Vane, United Kingdom, for their discoveries about ... "The Nobel Prize in Physiology or Medicine 1982". Nobel Foundation. Retrieved 2007-07-28.. ...
... as seen in Helicobacter pylori-induced gastric carcinoma. Parasitic infections associated with cancer include ... of cancers are due to infections such as Helicobacter pylori, hepatitis B, hepatitis C, human papillomavirus infection, Epstein ... "Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008" ...
Քաղցկեղ - Վիքիպեդիա՝ ազատ հանրագիտարան
புற்று நோய் - தமிழ் விக்கிப்பீடியா
Peter S, Beglinger C (2007). "Helicobacter pylori and gastric cancer: the causal relationship". Digestion 75 (1): 25-35. doi: ... Cheung TK, Xia HH, Wong BC (January 2007). "Helicobacter pylori eradication for gastric cancer prevention". J. Gastroenterol. ... Wang C, Yuan Y, Hunt RH (August 2007). "The association between Helicobacter pylori infection and early gastric cancer: a meta- ... Chang EH, Furth ME, Scolnick EM, Lowy DR (1982). "Tumorigenic transformation of mammalian cells induced by a normal human gene ...
Barry J. Marshall bahasa Indonesia, ensiklopedia bebas
Ia dikenal sebagai orang yang membuktikan bahwa bakteria Helicobacter pylori sebagai penyebab tukak lambung, menggantikan ... Robin Warren dianugerahi Penghargaan Nobel dalam Fisiologi atau Kedokteran berkat jasanya dalam penemuan Helicobacter pylori ... Saat ini ia menangani sebuah laboratorium biologi molekuler di Perth dan masih berkutat dengan dampak pylori pada manusia dan ... 1982) · McClintock (1983) · Jerne / Köhler / Milstein (1984) · Brown / Goldstein (1985) · Cohen / Levi-Montalcini (1986) · ...
Helicobacter pylori bahasa Indonesia, ensiklopedia bebas
"Helicobacter". Merriam-Webster Dictionary.. , "Pylori". Merriam-Webster Dictionary.. . *^ "pylori". Dictionary.com Unabridged. ... Wikimedia Commons memiliki media mengenai Helicobacter pylori.. *Information on tests for H. pylori from the National ... Helicobacter pylori, yang sebelumnya disebut Campylobacter pylori, adalah sebuah bakteri mikroaerofil Gram-negatif yang ... "Dalam Yamaoka Y. Helicobacter pylori: Molecular Genetics and Cellular Biology. Caister Academic Press. ISBN 1-904455-31-X.. ...
Lischt vu dr Nobelbryysdreger fir Fysiologii oder Medizin - Alemannische Wikipedia
fir d Entdeckig vum Magebakterium Helicobacter pylori un däm syyni Bedytig bi Gastritis un Magegschwir" ... 1886-1982) Deutschland. Dytschland (uf d Wält chuu z Wien, Öschtriich-Ungarn) „fir ihri Entdeckige zue dr Organisation un ... 1982 Sune Bergström. (1916-2004) Schweiz. Schwede „fir ihri bahnbrächende Arbete iber Prostaglandin un noo verwandte biologisch ... 1903-1982) Schweiz. Schwede „fir syyni Entdeckige iber Natur un Wirkigswyys vu dr Oxydationsenzym" ...
List of Nobel laureates in Physiology or Medicine
"for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease" . ... 1982 Sune K. Bergström Sweden "for their discoveries concerning prostaglandins and related biologically active substances"  ... "The Nobel Prize in Physiology or Medicine 1982". Nobel Foundation. Retrieved 28 July 2007.. ...
Handa O, Naito Y, Yoshikawa T (2011). "Redox biology and gastric carcinogenesis: the role of Helicobacter pylori". Redox Report ... helicobacter pylori infection produces high levels of reactive oxygen species that damage DNA and contributes to gastric cancer ... Heliobacter pylori is known to cause MALT lymphoma. Other types of bacteria have been implicated in other cancers. ... Chang EH, Furth ME, Scolnick EM, Lowy DR (June 1982). "Tumorigenic transformation of mammalian cells induced by a normal human ...
Kanser, ang malayang ensiklopedya
Daftar penerima Nobel Fisiologi atau Kedokteran bahasa Indonesia, ensiklopedia bebas
Poor immune function, autoimmune diseases, Helicobacter pylori infection, hepatitis C, obesity, Epstein-Barr virus infection ... Helicobacter pylori: associated with gastric lymphoma. *HHV-8: associated with primary effusion lymphoma, multicentric ... Helicobacter pylori infection, hepatitis C, obesity and Epstein-Barr virus infection. The World Health Organization (WHO ... Following its publication in 1982, the Working Formulation became the standard classification for this group of diseases. It ...
Randomized controlled trial
"Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early ... Appelbaum PS, Roth LH, Lidz C (1982). "The therapeutic misconception: informed consent in psychiatric research". Int J Law ... Although subjects almost always provide informed consent for their participation in an RCT, studies since 1982 have documented ... A 2005 review found 83 randomized experiments in criminology published in 1982-2004, compared with only 35 published in 1957- ...
ബാരി ജെ. മാർഷൽ - വിക്കിപീഡിയ
Բժշկության կամ ֆիզիոլոգիայի Նոբելյան մրցանակի դափնեկիրների ցանկ - Վիքիպեդիա՝ ազատ հանրագիտարան
for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease ... Ստամոքսի և տասներկումատնյա աղու գաստրիտի առաջացման վրա Helicobacter pylori բակտերիայի ազդեցության ուսումնասիրության ուղղությամբ ... 1982 Սունե Բերգստրեմ Պրոստացիկլինի և նրան մոտ կենսաբանական ակտիվ նյութերի բացահայտման համար։ ... The Nobel Prize in Physiology or Medicine 1982» (անգլերեն)։ Նոբելյան ֆոնդ։ Արխիվացված է օրիգինալից 2012-10-15-ին։ Վերցված է ...
Timeline of peptic ulcer disease and Helicobacter pylori - Wikipedia
Unge, Peter (2002). "Helicobacter pylori treatment in the past and in the 21st century". In Barry Marshall. Helicobacter ... Mozorov, Igor A., "Helicobacter pylori was discovered in Russia in 1974", in Helicobacter Pioneers, pp. 105-118. Freedberg, A. ... Steer, Howard W (2002). "The discovery of Helicobacter pylori in England in the 1970s". In Barry J. Marshall. Helicobacter ... Fukuda, Yoshihiro et al., "Kasai, Kobayashi and Kochs postulates in the history of Helicobacter pylori", in Helicobacter ...
Acute Helicobacter pylori Infection Is Followed by an Increase in Diarrheal Disease Among Peruvian Children | American Academy...
1995) Aspects of Helicobacter pylori infection in the developing and developed world. Helicobacter pyloriinfection, nutrition, ... 2000) Protection of BALB/C mice against experimentalHelicobacter pylori infection by oral immunisation withH. pylori heparan ... 1991) Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 325:1132-1136. ... Banatvala N. Helicobacter pylori acquisition in infancy after decline of maternal passive immunity. Pediatr Res. 41:641-646. ...
Patent US5477854 - System and method to monitor gastrointestinal Helicobacter pylori infection - Google Patents
... as an indicator of the presence and activity of an intragastrointestinal Helicobacter Pylori (HP) infection. Ambulatory ... More specifically, this data is used as an indicator of the presence of a Helicobacter Pylori ("HP") infection in the stomach ... 142 148, Use of an Ammonia Electrode for Rapid Quantification of Helicobacter pylori Urease: Its use in the Endoscopy Room and ... 142-148, "Use of an Ammonia Electrode for Rapid Quantification of Helicobacter pylori Urease: Its use in the Endoscopy Room and ...
IJMS | Free Full-Text | Structural Analysis of Hypothetical Proteins from Helicobacter pylori: An Approach to Estimate...
Based on genomic research of H. pylori, over 1600 genes have been functionally identified so far. However, H. pylori possess ... pylori) have a unique ability to survive in extreme acidic environments and to colonize the gastric mucosa. It can cause ... pylori. Thus, there are still a lot of genes to be biologically or biochemically characterized to understand the whole picture ... pylori. In addition, we show some successful approaches of elucidating the function of unknown proteins based on their ...
Molecular Pathways: Involvement of Helicobacter pylori-Triggered Inflammation in the Formation of an Epigenetic Field Defect,...
Japanese Society for Helicobacter Research. Guidelines for the management of Helicobacter pylori infection in Japan: 2009 ... Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001;345:784-9. ... Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology 2001;121: ... Helicobacter pylori CagA-a bacterial intruder conspiring gastric carcinogenesis. Int J Cancer 2006;119:1217-23. ...
Helicobacter pylori: su descubrimiento e importancia en la medicina
Is there a future for research on helicobacter pylori?. Even if the interest of investigators for Helicobacter pylori infection ... Helicobacter pylori: its discovery and relevance for medicine. Helicobacter pylori: su descubrimiento e importancia en la ... Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen.nov.as Helicobacter pylori comb.nov. and ... Helicobacter pylori in peptic ulcer disease: NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. ...
Helicobacter Pylori Membrane Protein 1: A New Carcinogenic Factor of Helicobacter Pylori | Cancer Research
Helicobacter Pylori Membrane Protein 1: A New Carcinogenic Factor of Helicobacter Pylori Masami Suganuma, Miki Kurusu, Sachiko ... Helicobacter Pylori Membrane Protein 1: A New Carcinogenic Factor of Helicobacter Pylori ... Helicobacter Pylori Membrane Protein 1: A New Carcinogenic Factor of Helicobacter Pylori ... Helicobacter Pylori Membrane Protein 1: A New Carcinogenic Factor of Helicobacter Pylori ...
NOVEL BINDING EPITOPES FOR HELICOBACTER PYLORI AND USE THEREOF - GLYKOS FINLAND OY
The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori, to a method of producing ... Helicobacter pylori,/i,, namely substances comprising oligosaccharide sequences Hex2(NAc)β4Glc(A)(NAc) and Hex1(A)(NAc)&agr / ... Helicobacter pylori,/i, in a subject, e.g. gastritis, gastric ulcers, gastric adenocarcinoma, liver disease, pancreatic disease ... The Helicobacter pylori binding substance can also comprise a mixture of the Helicobacter pylori binding oligosaccharide ...
Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a...
Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med2001; ... Parsonnet J, Friedman GD, Vandersteen DP, et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med ... Asaka M, Kimura T, Kato M, et al. Possible role of Helicobacter pylori infection in early gastric cancer development. Cancer ... Lin JT, Wang LY, Wang JT, et al. A nested case-control study on the association between Helicobacter pylori infection and ...
Helicobacter pylori porCDAB and oorDABCGenes Encode Distinct Pyruvate:Flavodoxin and 2-Oxoglutarate:Acceptor Oxidoreductases...
Helicobacter cinaedi, Helicobacter nemestrinae, Helicobacter felis, Helicobacter muridarium, Helicobacter acinonyx, ... 1991) Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 325:1127-1131. ... 1995) Kinetics of substrate oxidation by whole cells and cell membranes of Helicobacter pylori. FEMS Microbiol. Lett. 129:33-38 ... Helicobacter pylori, a major cause of human gastric disease, is a microaerophilic bacterium that contains neither pyruvate nor ...
Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine...
Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. Gut 2013;62:34-42. ... Management of Helicobacter pylori infection-the Maastricht IV/ Florence Consensus Report. Gut 2012;61:646-64. ... Sequential therapy for Helicobacter pylori eradication: a critical review. J Clin Gastroenterol 2010;44:313-25. ... Helicobacter pylori eradication therapy research: Ethical issues and description of results. Clin Gastroenterol Hepatol 2010;8: ...
Helicobacter pylori Test Kits | Quidel Rapid Visual Tests
Quidels innovative line of Helicobacter pylori products puts reliable tests in providers to detect Rapid Visual Tests. ... Helicobacter pylori. Helicobacter pylori (H. pylori) is a gram negative rod bacterial pathogen that resides in the mucous layer ... pylori Stool Antigen Test is a rapid membrane enzyme immunoassay for the qualitative detection of Helicobacter pylori specific ... Karakus, C., and B. A. Salih., Comparison of the lateral flow immunoassays (LFIA) for the diagnosis of Helicobacter pylori ...
Helicobacter pylori - Wikipedia
Blanchard, T G; Nedrud, J G (2010). "9. Helicobacter pylori Vaccines". In Sutton, Philip; Mitchell, Hazel. Helicobacter Pylori ... "Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. and ... "European Helicobacter Pylori Study Group (EHPSG). Current concepts in the management of Helicobacter pylori infection-the ... pylori from the National Institutes of Health European Helicobacter Study Group (EHSG) Type strain of Helicobacter pylori at ...
Ulcère (Helicobacter pylori)
The genus name, Helicobacter, stems from the Greek root, "helix" which describes the bacteriums curvy shape. Pylori stems from ... Most commonly, stomach ulcers are caused by bacteria called Helicobacter pylori. It spreads through contaminated water.. ... H. pylori is an S-shaped bacterium about 0.5 x 5 micrometers. It has 5 to 7 tails on one end, called polar flagella. ... Ulcère (Helicobacter pylori). Ulcère (Helicobacter pylori) GMEU-PD-0770 Épuisé. Produits associés. Ulcère (Helicobacter pylori ...
Ulcer (Helicobacter pylori)
All about Ulcer (Helicobacter pylori). FACTS: For many years, stress and spicy foods were thought to be the root causes of ... The genus name, Helicobacter, stems from the Greek root, "helix" which describes the bacteriums curvy shape. Pylori stems from ... Most commonly, stomach ulcers are caused by bacteria called Helicobacter pylori. It spreads through contaminated water.. ... In 1983, however, Australian physicians Barry Marshall and Robin Warren implicated Helicobacter pylori bacteria as causing the ...
Helicobacter pylori eradication: a randomised comparative trial of 7-day versus 14-day triple therapy
Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project. Am ... Helicobacter pylori was first isolated by Warren and Marshall in 1982. It is a Gram-negative bacterium found on the gastric ... BACKGROUND: Helicobacter pylori is associated with several upper gastrointestinal conditions including chronic gastritis, ... Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and ...
Medicine and Physiology Nobel Awarded to H. pylori Researchers - Scientific American
Eventually, with the involvement of other researchers, the microbe was named Helicobacter pylori. Researchers now know that ... H. pylori creates problems, because it naturally releases chemicals that attract cells that induce stomach irritation. The ... It took Warren, with the help of young trainee, Barry Marshall, until 1982 to finally cultivate the bacterium in the laboratory ...
Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA | JEM
1993) Helicobacter pylori: microbiology of a "slow" bacterial infection. Trends Microbiol 1:255-260, pmid:8162405.. ... 1993) An international association between Helicobacter pyloriinfection and gastric cancer. Lancet 341:1359-1362, pmid:8098787. ... 1996) The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol 20:241-246, pmid:8733223.. ... 1997) Vacuoles induced by Helicobacter pyloritoxin contain both late endosomal and lysosomal markers. J Biol Chem 272:25339- ...
Ulcers (for Teens) - Willis-Knighton Health System
The medical name for these bacteria is Helicobacter pylori (or H. pylori, for short). Today doctors know that most peptic ... When H. pylori bacteria do cause ulcers, heres how doctors think it happens:. *Bacteria weaken the protective coating of the ... A doctor can also do a blood test for H. pylori bacteria. This may be important if an ulcer is found in the upper GI series. ... Although H. pylori are responsible for most cases of peptic ulcers, these ulcers can happen for other reasons, too. Some people ...
Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl...
P. Bytzer and C. OMorain, "Treatment of Helicobacter pylori," Helicobacter, vol. 10, no. S1, pp. 40-46, 2005. View at ... A. Nomura, G. N. Stemmermann, P. H. Chyou, G. J. Perez-Perez, and M. J. Blaser, "Helicobacter pylori infection and the risk for ... F. Mauch, G. Bode, and P. Malfertheiner, "Identification and characterization of an ATPase system of Helicobacter pylori and ... Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl ...
Disappearing Microbiota: Helicobacter pylori Protection against Esophageal Adenocarcinoma | Cancer Prevention Research
... pylori (Fig. 1). Numerous studies have made it clear that H. pylori-positive and H. pylori-negative persons have substantial ... Helicobacter pylori infection and the risk of Barretts oesophagus: a community-based study. Gut 2008;57:727-33. ... Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions. J Natl Cancer Inst 2007;99:1328-34. ... Helicobacter pylori colonization is inversely associated with childhood asthma. J Infect Dis 2008;198:553-60. ...
Helicobacter pylori Virulence and Genetic Geography | Science
Helicobacter pylori Virulence and Genetic Geography. By Antonello Covacci, John L. Telford, Giuseppe Del Giudice, Julie ... Helicobacter pylori Virulence and Genetic Geography. By Antonello Covacci, John L. Telford, Giuseppe Del Giudice, Julie ... Helicobacter pylori antigens, vaccine formulations, and routes of administration proven efficacious in animal models of ... Helicobacter pylori (Hp) was part of the unknown microbial world (1). Today it is a well-recognized pathogen that chronically ...
Role of Energy Sensor TlpD of Helicobacter pylori in Gerbil Colonization and Genome Analyses after Adaptation in the Gerbil |...
Infections of Mongolian gerbils (Meriones unguiculatus) with H. pylori.Helicobacter pylori HP87 P7 wild type and chemotaxis ... Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. PLoS Pathog. 7:e1002050. doi: ... Role of Helicobacter pylori cag region genes in colonization and gastritis in two animal models. Infect. Immun. 69:2902-2908. ... Metastability of Helicobacter pylori bab adhesin genes and dynamics in Lewis b antigen binding. Proc. Natl. Acad. Sci. U. S. A. ...
WHO | Helicobacter pylori
Helicobacter pylori. The isolation of Helicobacter pylori from the human gastric mucosa in 1982 and the demonstration of its ... H. pylori is a small, spiral, gram-negative bacillus that appears to inhabit the mucous layer overlying the gastric epithelial ... Development of atrophy and metaplasia of the gastric mucosa are strongly associated with H. pylori infection. Oxidative and ...
Everything Else - Helicobacter Forums
Helicobacter pylori is also called H.pylori and is abbreviated Hp. It was first cultured in Perth Australia in 1982. Marshall ... Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. How long should I wait before doing ... Home Board index Other: Interesting, Old and New, Relevant or Not, about Helicobacters, or Not! Everything Else ... We shall provide the most accurate answer about H. pylori. You can help us by clicking here to help keep this forum alive.. ...
Everything Else 其他 - Helicobacter Forums
Helicobacter pylori is also called H.pylori and is abbreviated Hp. It was first cultured in Perth Australia in 1982. Marshall ... Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. The 5th Chinese Helicobacter treatment ... Other: Interesting, Old and New, Relevant or Not, about Helicobacters, or Not! 其他：趣闻，历史，新闻，相关，另类幽门螺杆菌. Everything Else 其他. ... 2 YR OLD* Mum of child untreated H.Pylori since 2 YRS OLD Last post by Helico_expert « Wed May 13, 2015 2:22 pm. ...
Historical Facts about Hp - Helicobacter Forums
Helicobacter pylori is also called H.pylori and is abbreviated Hp. It was first cultured in Perth Australia in 1982. Marshall ... Board index Everything Else Other: Interesting, Old and New, Relevant or Not, about Helicobacters, or Not! Historical Facts ... Other: Interesting, Old and New, Relevant or Not, about Helicobacters, or Not! ...
Delayed Gastric Emptying and Gastric Autoimmunity in Type 1 Diabetes | Diabetes Care
Helicobacter pylori.. HP IgG antibodies were assayed by enzyme-linked immunosorbent assay (Roche Diagnostics, Brussels, Belgium ... Perri F, Ghoos YF, Maes BD, Geypens BJ, Ectors N, Geboes K, Hiele MI, Rutgeerts PJ: Gastric emptying and Helicobacter pylori ... Peeters M, Ghoos Y, Geypens B, Rutgeerts P: Breath tests in Helicobacter pylori infection: methodological aspects. J Physiol ... Helicobacter pylori (HP), acid production, and gastric histology.. RESEARCH DESIGN AND METHODS-Gastric emptying of solids and ...
TraG-Like Proteins of DNA Transfer Systems and of the Helicobacter pylori Type IV Secretion System: Inner Membrane Gate for...
Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 ... TraG-Like Proteins of DNA Transfer Systems and of the Helicobacter pylori Type IV Secretion System: Inner Membrane Gate for ... Evidence for a conjugation-like mechanism of DNA transfer in Helicobacter pylori. J. Bacteriol. 180:2901-2905. ... TraG-Like Proteins of DNA Transfer Systems and of the Helicobacter pylori Type IV Secretion System: Inner Membrane Gate for ...
Kefir: Uses, Side Effects, Interactions, Dosage, and Warning
Ulcers caused by a bacterium called Helicobacter pylori (H. pylori). Early research shows that taking kefir along with standard ... It is also used to reduce levels of the bacteria Helicobacter pylori, found in association with ulcers. It is also used to ... Bekar O, Yilmaz Y, Gulten M. Kefir improves the efficacy and tolerability of triple therapy in eradicating Helicobacter pylori ... Jpn J Med Sci Biol 1982;35:75-80. View abstract.. *Simova E, Beshkova D, Angelov A, et al. Lactic acid bacteria and yeasts in ...
Developing peptic ulcersPeptic ulcerBiopsyBarry Marshall and Robin WarrenAntigenMarshallPathogenGenusRisk of gastricAntibodyOrganismColonizationGastroesophageal refluxIsolated from humans in 1982GastrointestinalUlcers were causedBacteria Helicobacter pyloriEndoscopyPatients with duodenalEpithelial cellsInflammationUreaseDevelopment of gastric cancerHumansEpidemiological studiesPhysiologyAntibioticType IV secretion systemStomach ulcersChronic gastritisAustralianBacterium calledHalf of the world'sAmong clinical isolatesEradicateInfectsProteinsDiscoveryClinicalGastric adenocarcinomaDiagnosisInfection with H pyloriResearchersDuodenumAsymptomaticMicroaerophilicAtrophyCarcinogenesis
Developing peptic ulcers1
- This is a timeline of the events relating to the discovery that peptic ulcer disease and some cancers are caused by H. pylori. (wikipedia.org)
- In 2005, Barry Marshall and Robin Warren were awarded the Nobel Prize in Physiology or Medicine for their discovery that peptic ulcer disease (PUD) was primarily caused by Helicobacter pylori, a bacterium with affinity for acidic environments, such as the stomach. (wikipedia.org)
- The Board members summarized their contribution to science with these words: "extraordinary and unexpected discovery that gastric inflammation (gastritis), as well as stomach and duodenal ulcer (peptic ulcer disease), result from a gastric infection by the bacterium Helicobacter pylori " (1). (isciii.es)
- This association with ulcer disease makes H. pylori the most common cause of non-NSAID or aspirin-related peptic ulcer disease. (quidel.com)
- Approximately one in six individuals infected with H. pylori will eventually develop peptic ulcer disease. (quidel.com)
- Helicobacter pylori is associated with several upper gastrointestinal conditions including chronic gastritis, peptic ulcer disease, and gatric malignancy. (scielo.org.za)
- Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. (sciencemag.org)
- The isolation of Helicobacter pylori from the human gastric mucosa in 1982 and the demonstration of its involvement in gastritis, peptic ulcer disease and gastric adenocarcinomas have radically changed our perception of these diseases. (who.int)
- ABSTRACT Helicobacter pylori the causative organism and has a possible role in the development of peptic ulcer disease (PUD) and gastric cancer. (issuu.com)
- KEYWORDS: Helicobacter pylori, Peptic Ulcer Disease, NSAIDs INTRODUCTION Helicobacter pylori (formerly known as campylobacter pylori) were first isolated from humans in 1982 . (issuu.com)
- Of special significance is that H.pylori is present in most persons with "idiopathic" peptic ulcer disease(PUD). (issuu.com)
- The presence of H.pylori increases peptic ulcer disease and gastric cancer [3, but decreases the risk of esophageal reflux and its consequences, and may protect against childhood asthma and related disorders [5, (issuu.com)
- H. pylori infection cause upper gastrointestinal diseases including gastritis, peptic ulcer disease and also increase the risk of gastric cancer. (biomedcentral.com)
- This year's Nobel Laureates in Physiology or Medicine made the remarkable and unexpected discovery that inflammation in the stomach (gastritis) as well as ulceration of the stomach or duodenum (peptic ulcer disease) is the result of an infection of the stomach caused by the bacterium Helicobacter pylori . (nobelprize.org)
- In 1982, when this bacterium was discovered by Marshall and Warren, stress and lifestyle were considered the major causes of peptic ulcer disease. (nobelprize.org)
- The link between Helicobacter pylori infection and subsequent gastritis and peptic ulcer disease has been established through studies of human volunteers, antibiotic treatment studies and epidemiological studies. (nobelprize.org)
- The prevalence of Helicobacter pylori in peptic ulcer disease. (springer.com)
- Helicobacter pylori is closely related with gastritis, peptic ulcer, gastric cancer and gastric MALT lymphoma, and it may participate in a variety of parenteral diseases. (bioportfolio.com)
- Professor Marshall, 54, and Dr Warren, 68, are cited for their 1982 discovery of "the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease. (bmj.com)
- The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. (sciencemag.org)
- H elicobacter pylori , a human-specific gastric pathogen, was first isolated in 1982 ( 1 ) and has emerged as the causative agent of chronic active gastritis and peptic ulcer disease ( 2 ). (sciencemag.org)
- the role of H. pylori in peptic ulcer disease was firmly established it revolutionized the treatment of this condition. (ubc.ca)
- However, in 1982, two Australian medical researchers (Barry J Marshall and J Robin Warren) discovered the bacterium Helicobacter pylori and demonstrated its role in gastritis and peptic ulcer disease. (mja.com.au)
- The strong association between H. pylori infection and peptic ulcer disease is unarguable. (pubmedcentralcanada.ca)
- In 2005, Barry J. Marshall and J. Robin Warren were awarded the Nobel Prize for Physiology or Medicine in recognition of their 1982 discovery that a bacterium, Helicobacter pylori, is one cause of mankind's most common and serious diseases, peptic ulcer disease. (infowars.com)
- He has published over 600 papers and abstracts including authoritative papers on clinical pharmacology, peptic ulcer disease, gastroesophageal reflux disease, Helicobacter pylori infection, colonic disease, and colonoscopy. (mcmaster.ca)
- Two Australian researchers, Barry Marshall and Robin Warren identified a bacteria, Helicobacter pylori, that was consistently present in cases of peptic ulcer disease. (foodsafetynews.com)
- The medical establishment initially responded with skepticism, but over the next twenty years the role of H. pylori in peptic ulcer disease and the treatment of it with antibiotics became an accepted part of basic medicine. (foodsafetynews.com)
- Given the association between H. pylori and peptic ulcer disease, gastric cancer, and B-cell mucosa-associated lymphoid tissue (MALT) lymphoma, there is an urgent need for the development of intervention strategies to prevent the spread of the bacterium. (asmscience.org)
- H. pylori and Peptic Ulcer. (howstuffworks.com)
- But since the 1982 isolation of H. pylori by Australian researchers Barry Marshall and Robin Warren, many have believed that the spiral organism plays a significant causal role in peptic ulcer disease, and there has been growing interest in using antibiotics to treat ulcers. (encognitive.com)
- Most people have no symptoms (possibly because some strains of H. pylori do not produce cytotoxins) but each year about 1% of H. pylori -infected adults develop peptic ulcer. (thefreedictionary.com)
- Diagnosis of H.pylori infection both by invasively by endoscopy and biopsy or noninvasively by serologic analysis, and breath test. (issuu.com)
- It is almost 40 years since Barry Marshal and Robin Warrens identified and recovered Helicobacter pylori (H. pylori) from gastric biopsy specimens. (bioportfolio.com)
- H. pylori can be diagnosed by testing the blood for antibodies , a urea breath test , testing the stool for signs of the bacteria, or a biopsy of the stomach. (wikipedia.org)
- Helicobacter pylori has been the subject of intense investigation since its culture from a gastric biopsy in 1982. (asmscience.org)
- As noted above, with a short time after the discovery of H. pylori, rapid urease tests had been developed to allow rapid detection of H. pylori using gastric specimens (mucus, biopsy, or. (1000friends-ct.org)
- The organism was first observed in 1982 by Robin Warren and Barry J. Marshall at Royal Perth Hospital in Western Australia in biopsy specimens from patients with chronic gastritis. (thefreedictionary.com)
Barry Marshall and Robin Warren6
- It was identified in 1982 by Australian scientists Barry Marshall and Robin Warren, who found that it was present in a person with chronic gastritis and gastric ulcers, conditions not previously believed to have a microbial cause. (wikipedia.org)
- In 1983, however, Australian physicians Barry Marshall and Robin Warren implicated Helicobacter pylori bacteria as causing the condition. (giantmicrobes.com)
- In 1982, two doctors - Barry Marshall and Robin Warren - discovered a certain kind of bacteria that can live and grow in the stomach. (kidshealth.org)
- H. pylori was first identified as causing peptic ulcers by Barry Marshall and Robin Warren in the late 20th century, a discovery for which they received the Nobel Prize in 2005. (wikipedia.org)
- This theory was first postulated in 1982 by Barry Marshall and Robin Warren however it was widely rejected by the medical community believing that no bacterium could survive for long in the acidic environment of the stomach. (midasoracle.org)
- Doctors were certain stomach ulcers were generated by diet and stress until in 1982, Australian scientists Barry Marshall and Robin Warren discovered that most ulcers were caused by Helicobacter pylori , cured by medication. (tikkun.org)
- The QuickVue TLI H. pylori Stool Antigen Test is a rapid membrane enzyme immunoassay for the qualitative detection of Helicobacter pylori specific. (quidel.com)
- All patients who presented between December 2009 and May 2010 with dyspepsia and who were positive for H. pylori on stool antigen tests were enrolled. (scielo.org.za)
- The results presented here suggest that VacA may contribute to the persistence of H. pylori by interfering with protective immunity and that this toxin is a new useful tool in the study of the different pathways of antigen presentation. (rupress.org)
- Biopsies from patients affected by gastroduodenal ulcers almost invariably contain H. pylori strains harboring a pathogenicity island (( 4 )), characterized by the presence of the gene encoding for the 128-kD CagA protein, the major H. pylori antigen. (rupress.org)
- The Maastricht IV/Florence Consensus Report recommends the 13C-UBT and stool antigen test to detect H. pylori infection, due to high sensitivity and specificity [ 7 ]. (omicsonline.org)
- The H. pylori infection can be detected by submitting a stool sample (stool antigen test) or by using a device to measure breath samples after swallowing a urea pill (urea breath test). (harvard.edu)
- Biochemical characterization of the blood group antigen-binding (BAB) activity of H. pylori . (sciencemag.org)
- Five H. pylori strains ( 7 ) were incubated with 125 I-labeled blood group antigen glycoconjugates ( 8 ). (sciencemag.org)
- D ) Scatchard analysis of the H. pylori -Le b antigen interaction. (sciencemag.org)
- We have now biochemically characterized and identified the H. pylori blood group antigen-binding adhesin, BabA. (sciencemag.org)
- Diagnostic Automation Helicobacter pylori Antigen ELISA Test is a quantitative assay for the detection of H. pylori antigens in human stool specimens. (rapidtest.com)
- All above positive samples were tested negative for Helicobacter pylori Antigen test. (rapidtest.com)
- Diluted patient serum is added to wells and H. pylori IgM specific antibody, if present, binds to the antigen. (rapidtest.com)
- Both the H. pylori lysate antigen and rUreG protein displayed a distinctive band at the expected molecular weight when probed with the hyperimmune mice serum. (biomedcentral.com)
- First discovered in 1982 by two Australian researchers named Robin Warren and Barry Marshall. (giantmicrobes.com)
- Helicobacter pylori was first isolated by Warren and Marshall in 1982. (scielo.org.za)
- It took Warren, with the help of young trainee, Barry Marshall, until 1982 to finally cultivate the bacterium in the laboratory. (scientificamerican.com)
- Marshall, B.J. (1994) Helicobacter pylori Am J Gastroenterol 89 , S116-28. (springer.com)
- After several attempts, Marshall succeeded in cultivating a hitherto unknown bacterial species (later denoted Helicobacter pylori ) from several of these biopsies. (nobelprize.org)
- Bakteri tersebut diidentifikasikan pada 1982 oleh ilmuwan Australia Barry Marshall dan Robin Warren yang menemukan bahwa bakteri itu hadir pada orang dengan gastritis dan ulkus peptikum kronis, kondisi yang sebelumnya tidak diyakini memiliki penyebab mikroba . (wikipedia.org)
- In 1982, two physicians from Perth, Australia, Dr. Robin Warren and Dr. Barry Marshall, again observed bacteria associated with ulcerated and inflamed regions of human gut and began investigating its role in disease. (news-medical.net)
- After a long trial and error period, Warren and Marshall figured out how to grow H. pylori in culture, which occurred by chance after inadvertently leaving the culture to grow over a long Easter holiday. (news-medical.net)
- Using themselves as test subjects, Marshall and another volunteer ingested a culture of H. pylori and soon developed gastritis, thus definitively establishing a link between the infectious agent and disease. (news-medical.net)
- Warren and Marshall published their work in 1982 and were awarded the Nobel Prize in Medicine in 2005 for their outstanding contributions to the field. (news-medical.net)
- In 1982, Australian physicians Robin Warren and Barry Marshall found ulcers were caused by the Helicobacter pylori (H. pylori) bacterium, not stress or diet. (edmontonjournal.com)
- Over a busy Easter weekend in 1982, Marshall had forgotten to examine the culture dish for bacteria for a few days. (ukessays.com)
- Warren and Marshall called it Helicobacter pylori (H. pylori). (ukessays.com)
- In 1984, after failed attempts to infect piglets, Marshall fasted until 10 am and then drank a Petri dish containing cultured H. Pylori, expecting to develop an ulcer. (ukessays.com)
- After Robin Warren discovered colonies of bacteria at gastric ulcer sites, he was contacted by his colleague Barry Marshall, who then successfully cultivated the previously unknown bacteria Helicobacter pylori. (nobelprize.org)
- Robin Warren and Barry Marshall proved in 1982 that patients could only be cured if the bacteria were eliminated. (nobelprize.org)
- In fact, it was the first detailed classification after the discovery of Helicobacter pylori by Warren and Marshall in 1982. (dovepress.com)
- When the Australian scientists J. Robin Warren and Barry Marshall identified the new bacteria Helicobacter pylori in 1982 as a cause of peptic ulcers disease, it completely transformed our understanding of the microbiology and pathology of the human stomach. (ubc.ca)
- In 2005, Warren and Marshall were awarded the Nobel Prize in Medicine for their work on H. pylori. (midasoracle.org)
- Helicobacter pylori is a spiral bacterium cultured from human gastric mucosa identified by Marshall in 1982. (rapidtest.com)
- Since the discovery of Helicobacter pylori by Warren and Marshall [ Marshall and Warren, 1984 ] in 1982, much has been learned about this Gram-negative microaerophilic bacterium and its associated pathology. (pubmedcentralcanada.ca)
- In 1982, a scientist named Barry Marshall proved that the helicobacter pylori bacteria (known as H. pylori) cause most peptic ulcers, even those in your stomach. (healthiertalk.com)
- Things changed when Dr. Barry Marshall, who had done quite a bit of research on the matter with Dr. Robert Warren, drank an entire beaker teeming with Helicobacter pylori . (bodyecology.com)
- Prior to his experiment in 1982, Marshall had found H. pylori in the stomachs of patients with gastritis and stomach ulcers. (bodyecology.com)
- The medical community was hard-pressed to believe that gastritis was linked to a bug in the stomach until, ten days after Marshall drank the H. pylori culture, an endoscopy showed signs of gastritis and H. pylori . (bodyecology.com)
- It wasn't until 1982 that Barry Marshall first reported that the bacterium, Helicobacter Pylori, caused stomach ulcers, for which he and Robin Warren received the Nobel Prize in 2005. (drmirkin.com)
- The discovery of the bacterium in 1982 by B.J. Marshall and R. I. Warren had a tremendous impact on basic research and clinical medicine, resulting, in the past 3 decades, in more than 34,000 published articles. (eurekaselect.com)
- He and his colleague, Dr. Barry Marshall, cultured the newly discovered bacteria, later named Helicobacter pylori, from tissue samples. (howstuffworks.com)
- So, Dr. Marshall experimented on himself, drinking a beaker full of H. pylori . (howstuffworks.com)
- About 10 years after the National Institutes of Health finally stated that ulcers were mostly caused by H. pylori and could be treated with antibiotics, Warren and Marshall were awarded the Nobel Prize in Physiology or Medicine for their groundbreaking discovery. (howstuffworks.com)
- Helicobacter pylori ( H. pylori ) is a gram negative rod bacterial pathogen that resides in the mucous layer of the antral and fundal gastric epithelium and occasionally in ectopic gastric tissue in the duodenum or esophagus. (quidel.com)
- In 1982, researchers reported a link between chronic gastritis and stomach bacterium Helicobacter pylori, triggering a flurry of research into this newly-identified pathogen. (news-medical.net)
- Helicobacter pylori is a human pathogen and during the process of infection, antigens from the bacterium elicit strong host humoral immune responses. (biomedcentral.com)
- Consider E. coli O157:H7 which was identified as a human pathogen in 1982, some 17 years after the serious complication it can cause, the hemolytic uremic syndrome (HUS) was first described by a Swiss physician. (foodsafetynews.com)
- After it was identified in 1982, scientists pegged it as a harmful pathogen. (nhpr.org)
- Cooperating with microbiologists they classify the new bacteria within the Helicobacter genus as the pylori species. (isciii.es)
- The genus name, Helicobacter, stems from the Greek root, "helix" which describes the bacterium's curvy shape. (giantmicrobes.com)
- Bentuk heliks H. pylori ini (dari hal itu nama genus berasal) diperkirakan telah berevolusi untuk menembus lapisan bermukus perut. (wikipedia.org)
- H. pylori is a member of a rapidly growing genus. (asmscience.org)
Risk of gastric4
- Infection with H. pylori is associated with an increased risk of gastric adenocarcinoma and has attracted attention as a cofactor in the pathogenesis of this malignant condition [ 4 ]. (mdpi.com)
- Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. (bmj.com)
- The estimated odds ratio for the risk of gastric cancer in those with a history of infection with H pylori was 2.77 (95% confidence interval 1.04 to 7.97, 2p = 0.039). (bmj.com)
- The epidemiological study EUROGAST included populations from both Asian and Western countries and demonstrated a six-fold increased risk of gastric cancer in H. pylori infected populations compared with uninfected populations [EUROGAST Study Group, (pubmedcentralcanada.ca)
- The combination of serum pepsinogen and anti- H pylori antibody provides a good predictive marker for the development of gastric cancer. (bmj.com)
- 6- 9 In earlier epidemiological studies using H pylori antibody as a marker of infection, various risk ratios of H pylori infection for gastric cancer were reported, ranging widely from none to 10 or above. (bmj.com)
- Presence of H pylori antibody (greater than 10 micrograms IgG/ml) determined by enzyme linked immunosorbent assay (ELISA). (bmj.com)
- RESULTS--20 of the 29 cases (69%) and 54 of the 116 controls (47%) were positive for H pylori specific antibody. (bmj.com)
- H. pylori infection is commonly diagnosed using an anti-H. pylori IgG antibody test. (omicsonline.org)
- However, the anti- H. pylori IgG antibody test is typically used to check infection, particularly in health check-ups in Japan, because it is simple and inexpensive [ 8 ]. (omicsonline.org)
- Helicobacter pylori Antibody Titer and Gastric Cancer Screening. (bioportfolio.com)
- Purified H. pylori antibody is coated on the surface of microwells. (rapidtest.com)
- An aliquot of diluted stool sample is added to wells, and the H. pylori antigens, if present, bind to the antibody. (rapidtest.com)
- H. pylori elisa testing the presence of H. pylori specific IgM antibody is the technique of choice for serologic tests because of its accuracy and simplicity. (rapidtest.com)
- Negative: H. pylori M Index of 0.90 or less are seronegative for IgM antibody to H. pylori. (rapidtest.com)
- H. pylori is highly motile due to its flagella which enables the organism to move within the mucous layer of the stomach. (quidel.com)
- Testing and identification of H. pylori is important because medications are available that can eradicate this organism. (quidel.com)
- Clone libraries of 16S rRNA genes show that H. pylori is the most numerous organism in the human stomach ( 16 ), in contrast with most other human niches where no single organism dominates persistently. (aacrjournals.org)
- With medical advances and introduction of new antimicrobial agents with extended spectrum against H.pylori, the high mortality rate associated with the organism in gastric cancer continues. (issuu.com)
- They isolated the bacteria from stomach biopsies and named the organism Helicobacter pylori . (news-medical.net)
- Cogent explanations of the adaptation of H. pylori to the gastric environment and the regulation of its physiology by environmental factors are given for a substantial body of experimental knowledge by placing it in the framework of the genome of the organism. (asmscience.org)
- The presence of H. pylori in the gastric juice of up to 58% of patients infected with H. pylori raises the possibility that refluxed gastric juice may represent a vehicle of transmission for the organism. (asmscience.org)
- Scientists theorize that the H. pylori organism weakens the stomach's protective mucous membrane, so that even small amounts of stomach acid can cause new ulcers or delay the healing of existing ones. (healthcommunities.com)
- In addition, the organism has been implicated in some cases of cholecystitis and autoimmune thyroiditis, and some studies have suggested that gastric infection with H. pylori may be a factor, by an unknown mechanism, in some cases of sudden infant death syndrome (SIDS). (thefreedictionary.com)
- Advances in molecular biology in the late 20th century led to the sequencing of the H. pylori genome, resulting in a better understanding of virulence factors responsible for its colonization and infection, on the DNA level. (wikipedia.org)
- In developing countries, H. pylori colonization is almost universal by age 20. (quidel.com)
- Helicobacter pylori maintains colonization in its human host using a limited set of taxis sensors. (asm.org)
- We studied the impact of H. pylori TlpD on colonization in vivo using a gerbil infection model which closely mimics the gastric physiology of humans. (asm.org)
- In conclusion, a gerbil-adapted H. pylori strain with a stable genome has helped to establish that TlpD has important functions for persistent colonization in the stomach. (asm.org)
- Outstanding H.pylori characteristics that permit gastric colonization include microerophilism for survival within mucus gel, spiral shape and flagella for motility within the viscous layer and urease activity, which generate ammonium ions that buffer gastric acidity . (issuu.com)
- Human studies have shown that the presence of anti- H. pylori IgA in maternal milk is associated with delayed colonization in infants, suggesting that IgA can block infection. (biomedcentral.com)
- They concluded that the probiotic treatment partially relieved the damage of gastric tissue caused by H. pylori colonization and that the probiotic has functional activity against H. pylori . (bodyecology.com)
- Despite the fact that evidence has shown clearly H. pylori to be the culprit for gastritis, peptic ulcers and gastric malignancies including mucosa associated lymphoid tissue (MALT) lymphoma and gastric adenocarcinoma, the effect of H. pylori treatment in patients with gastroesophageal reflux disease remains controversial. (pubmedcentralcanada.ca)
- More than 50% of the world's population have H. pylori in their upper gastrointestinal tract. (wikipedia.org)
- Thyroid function ( 19 ), gastric acid secretion ( 20 , 21 ), or Helicobacter pylori (HP) infection ( 22 ) may also modulate gastrointestinal motility. (diabetesjournals.org)
- In a recent guideline update , the American College of Gastroenterology also suggests H. pylori testing if you are on long-term aspirin therapy or starting long-term NSAID therapy (e.g., ibuprofen, naproxen) to help reduce the risk of developing ulcers and gastrointestinal bleeding. (harvard.edu)
- Studies have indicated that the presence of H. pylori is associated with a variety of gastrointestinal diseases including gastritis, duodenal and gastric ulcer, non-ulcer dyspepsia, gastric adenocarcinoma and lymphoma. (rapidtest.com)
- Diagnostic Automation offers H. pylori IgM ELISA kit for evaluating the serologic status to H. pylori infection in patients with gastrointestinal symptoms. (rapidtest.com)
Ulcers were caused1
Bacteria Helicobacter pylori3
- It is also used to reduce levels of the bacteria Helicobacter pylori , found in association with ulcers. (webmd.com)
- Common causes include the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs). (wikipedia.org)
- However, more recently the focus has been on the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen. (iherb.com)
- By using technologies generally available (fibre endoscopy, silver staining of histological sections and culture techniques for microaerophilic bacteria), they made an irrefutable case that the bacterium Helicobacter pylori is causing disease. (nobelprize.org)
- During an endoscopy the doctor can take tissue samples (biopsies) if necessary, as well as do H. pylori testing. (harvard.edu)
- An endoscopy showed inflammation of the stomach lining, with H. pylori bacteria around the area. (howstuffworks.com)
Patients with duodenal3
- H. pylori is found in 90% of patients with duodenal ulcers and in 50-80% of patients with gastric ulcers. (quidel.com)
- Randomised control trial of short term treatment eradicating Helicobacter pylori in patients with duodenal ulcer. (springer.com)
- The positive sera were from culture-positive H. pylori -infected patients with duodenal ulcers, gastric ulcers, or gastritis. (biomedcentral.com)
- H. pylori strains can be subdivided on the basis of cagA , a marker gene for the presence of the cag island, a chromosomal region that encodes a type IV secretion system that injects H. pylori constituents (including the cagA protein) into human gastric mucosal epithelial cells ( 17 , 18 ). (aacrjournals.org)
- H.pylori overlies only gastricâ€"type not intestinal-type, epithelial cells. (issuu.com)
- The sources of ROS are thought to be activated NADPH oxidase and CagA in H. pylori -infected gastric epithelial cells. (springer.com)
- H. pylori increases mRNA expression of trypsinogen 1 and 2 as well as the level and the activity of trypsin in gastric epithelial cells. (springer.com)
- H. pylori -induced production of ROS may mediate PAR2-mediated expression of integrins in gastric epithelial cells. (springer.com)
- Lipopolysaccharides From Non-Helicobacter pylori Gastric Bacteria Potently Stimulate Interleukin-8 Production in Gastric Epithelial Cells. (bioportfolio.com)
- The fucosylated blood group antigens Lewis b (Le b ) and H-1 (Fig. 1 A) mediate adherence of H. pylori to human gastric epithelial cells in situ ( 6 ). (sciencemag.org)
- Specific types of inflammation, such as that induced by H. pylori infection, are important for methylation induction, and infiltration of monocytes appears to be involved. (aacrjournals.org)
- It is known that when H. pylori infects the human stomach, it induces severe inflammation, including ulcers, then chronic inflammation, and finally gastric cancers within tens of years. (aacrjournals.org)
- However, H. pylori possibly plays a role only in the first stage that leads to common chronic inflammation, but not in further stages leading to carcinogenesis. (wikipedia.org)
- Therefore, scavenging of ROS or specific inhibition of NF-κB and AP-1 may be an effective strategy for prevention or treatment of gastric inflammation associated with H. pylori infection. (springer.com)
- In this chapter we will discuss oxidative stress and inflammation in gastric mucosa caused by H. pylori infection in the context of roles of ROS, transcription factors, signaling mediators, proinflammatory molecules and PAR2. (springer.com)
- Blaser, M. J. (1992) Hypothesis on the pathogenesis and natural history of Helicobacter pylori -induced inflammation Gastroenterology 102 , 720 -7. (springer.com)
- As first reported by Robin Warren, the presence of Helicobacter pylori is always associated with an inflammation of the underlying gastric mucosa as evidenced by an infiltration of inflammatory cells. (nobelprize.org)
- The severity of this inflammation and its location in the stomach is of crucial importance for the diseases that can result from Helicobacter pylori infection. (nobelprize.org)
- The current view is that the chronic inflammation in the distal part of the stomach caused by Helicobacter pylori infection results in an increased acid production from the non-infected upper corpus region of the stomach. (nobelprize.org)
- In 1982, two Australian scientists discovered that a certain bacterium, Helicobacter pylori , was a common cause of persistent stomach inflammation and stomach ulcers. (harvard.edu)
- Now, almost four decades later, researchers from Kanazawa University and the Japan Agency for Medical Research and Development have finally shown how inflammation caused by H. pylori infection causes the proliferation of gastric epithelial stem cells, leading to gastric tumors . (medicalxpress.com)
- Inflammation caused by H. pylori infection also produces ROS, increasing oxidative stress in the stomach. (medicalxpress.com)
- Helicobacter pylori (H. pylori or, as it is sometimes termed, stomach bacteria) is a spiral shaped bacterium that can cause chronic inflammation of the inner lining of the stomach (gastritis) and in duodenum in humans. (1000friends-ct.org)
- Bhas 42 and BALB/3T3 cells were similarly transfected by urease B gene of H. pylori or vector alone. (aacrjournals.org)
- This study shows that TNF-α protein, induced by both HP-MP1 and urease B, resulted in cell transformation in cooperation with viral Ras protein, strongly suggesting a new carcinogenic mechanism of human stomach cancer development associated with H. pylori infection. (aacrjournals.org)
- Methods: H. pylori infection (Hp+ or Hp-) was determined based on culture test, rapid urease test (RUT), and polymerase chain reaction (PCR) test in 280 outpatients. (omicsonline.org)
- Bleeding ulcers have high false negative rates for antral Helicobacter pylori when tested with urease test. (springer.com)
- Insight into the inhibitory effects of Zanthoxylum nitidum against Helicobacter pylori urease and jack bean urease: Kinetics and mechanism. (bioportfolio.com)
- The fact that H. pylori is both abundant in the stomach and contains urease has been widely used to assist in clinical diagnosis. (1000friends-ct.org)
- These include blood tests to measure the urease-secreting properties of H. pylori. (encognitive.com)
Development of gastric cancer1
- In the western world, about 30 to 50% of individuals may be infected with H. pylori , making it among the most common infections in humans. (asm.org)
- Understanding the relationship between H. pylori and humans is necessary to begin addressing this question. (aacrjournals.org)
- H. pylori in humans was nearly omnipresent until recently. (aacrjournals.org)
- Therefore, there is biological cost to humans to carry H. pylori , the removal of which may improve public health in some areas of the world ( 25 ). (aacrjournals.org)
- Helicobacter pylori chronically colonizes the gastric mucus layer of humans and induces chronic gastritis and, in severe cases, mucosa-associated lymphoid tissue lymphoma or adenocarcinoma of the stomach ( 1 ). (asm.org)
- H.pylori has been isolated from persons from all parts of the world, it now appears likely that, humans are the major, if not sole, reservoir for H.pylori [7, (issuu.com)
- Chronic infection is associated with the development of gastric adenocarcinoma, one of the most common types of cancer in humans ( 3 ), and H. pylori was recently defined as a class 1 carcinogen ( 4 ). (sciencemag.org)
- On the basis of genetic evidence, Blaser believes the H. pylori bacterium has been helping and hindering humans since way before the iceman. (nhpr.org)
- The pathogenic role of Helicobacter pylori for gastric cancer has been documented in a large number of epidemiological studies 1- 5 and basic research investigations. (bmj.com)
- Helicobacter pylori (H. pylori) is associated with gastric cancer in epidemiological studies.Gastric atrophy and intestinal metaplasia caused by H. pylori are considered as precancerous le. (bioportfolio.com)
- These tests are important for performing epidemiological studies for H. pylori infection rates. (news-medical.net)
- The physiology and metabolism of H. pylori are not well understood. (asm.org)
- Numerous studies have made it clear that H. pylori -positive and H. pylori -negative persons have substantial differences in gastric physiology and in tissue and immune responses ( 15 ). (aacrjournals.org)
- This new volume offers a comprehensive survey of Helicobacter biology, ranging from fundamental bacteriology through energy metabolism and synthetic pathways, physiology and molecular biology, genetics, epidemiology, virulence and pathogenic mechanisms, pathogenesis in the host, diagnosis and treatment, and the relationship between Helicobacter pylori and other Helicobacter species. (asmscience.org)
- The purpose of this study is to compare the effectiveness of three different antibiotic regimens against Helicobacter pylori (H. pylori). (bioportfolio.com)
- The antimicrobial resistance of helicobacter pylori in Shandong province was analyzed by helicobacter pylori antibiotic sensitivity test.And the map of antimicrobial resistance of helicoba. (bioportfolio.com)
- 9. Malfertheiner P "Compliance, adverse events and antibiotic resistance in Helicobacter pylori treatment. (drugs.com)
- Their investigations, including self-infection with H. pylori, demonstrated that antibiotic treatment could rid the gut of the bacteria and cure ulcers. (foodsafetynews.com)
Type IV secretion system1
- Most commonly, stomach ulcers are caused by bacteria called Helicobacter pylori. (giantmicrobes.com)
- the theory of Helicobacter pylori as the cause of stomach ulcers. (midasoracle.org)
- Antimicrobial drugs kill microorganisms such as H. pylori, a bacterium said to infect 80 percent of patients with stomach ulcers. (encognitive.com)
- Helicobacter pylorus is one of the pathogens involved in various gastric diseases such as peptic ulcers, chronic gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric cancer [ 1 - 3 ]. (mdpi.com)
- Helicobacter pylori (H. pylori) infection, affecting an estimated 50% of the global population, is a main cause of chronic gastritis, peptic ulcers and gastric cancer. (bioportfolio.com)
- Most of the individuals infected with H. pylori remain asymptomatic for life however it may lead to acute and chronic gastritis, gastric and mucosal ulcers, lymphoma and gastric carcinoma. (thefreelibrary.com)
- Helicobacter pylori infection causes chronic gastritis, which further induces expression of Noxo1 through TNF-α/NF-κB inflammatory cytokine pathway. (medicalxpress.com)
- In 1982, Dr. Robin Warren, an Australian doctor working with patients who had peptic ulcers and gastritis, observed a small bacteria present in the stomachs of about half of his patients. (howstuffworks.com)
- Then in 1982 two Australian researchers discovered that a bacterium called Helicobacter pylori (H. pylori) was present in more than 90 percent of duodenal ulcers and more than 73 percent of gastric ulcers. (healthcommunities.com)
Half of the world's1
Among clinical isolates1
- In Peru, diarrhea is a major cause of childhood morbidity, and H pylori infects up to 50% of children and 90% of older adults. (aappublications.org)
- H. pylori infection is ubiquitous and infects both males and females. (asmscience.org)
- Research indicates that H. pylori infects approximately six in ten people in the United States by age 60, while the infection rate in developing countries is eight in ten people by age 5. (encognitive.com)
- TraG-like proteins also function as essential components of type IV secretion systems of several bacterial pathogens such as Helicobacter pylori . (asm.org)
- Here we present the biochemical characterization of three members of the family of TraG-like proteins, TraG (RP4), TraD (F), and HP0524 ( H. pylori ). (asm.org)
- Fortunately, much has been learned about H. pylori since its discovery and isolation in pure culture in 1982. (aacrjournals.org)
- Up until the discovery of H. pylori in 1982, clinicians attributed peptic ulcers to lifestyle choices-consuming a diet rich in spicy foods and an inability to properly manage emotional and personal stress. (news-medical.net)
- The road to discovery of the Helicobacter pylori bacteria as the infectious agent in gastritis and peptic ulcers was a long one. (news-medical.net)
- Warren and Marshall's discovery opened the floodgates for H. pylori research. (news-medical.net)
- Fifteen years after the discovery of H. pylori, the U.S. Centers for Disease Control and Prevention launched a sweeping campaign to educate professionals and consumers alike, prompted by a U.S. study that revealed nearly 90 per cent of sufferers blamed ulcers on stress or worry, and 60 per cent believed diet was also a factor. (edmontonjournal.com)
- All this reminds me of the discovery that Helicobacter pylori causes ulcers. (blogspot.com)
- In the current study, we aimed to investigate additional metabolic parameters and their clinical impact with regard to H. pylori infection in a Chinese population. (biomedcentral.com)
- The genetic differences of H. pylori isolates, particularly in H. pylori virulence-associated genes, cag A , vac A and ice A genes, may influence the differential expression of inflammatory genes and clinical outcome of the infection. (springer.com)
- Therefore, the accurate diagnosis of H. pylori infection is of clinical importance. (omicsonline.org)
- In addition, a causal relationship between Helicobacter pylori and both gastric adenocarcinoma and gastric lymphoma has been established, and its association with some extra-digestive conditions has been suggested. (isciii.es)
- In the same year, the International Agency for Research on Cancer (IARC) declared H. pylori to be a group I human carcinogen for gastric adenocarcinoma [IARC, (pubmedcentralcanada.ca)
- Comparison of the lateral flow immunoassays (LFIA) for the diagnosis of Helicobacter pylori infection, 2013, J Immunol Methods 396:8-14. (quidel.com)
- SUBJECTS--29 men with a subsequent diagnosis of gastric cancer and 116 aged matched controls selected from over 22,000 middle aged men participating in two ongoing cohort studies (the British United Provident Association study and the Caerphilly collaborative heart disease study), who had provided blood samples during 1975-1982. (bmj.com)
Infection with H pylori2
- 1-8 Chronic infection with H pylori -which is typically acquired in childhood and persists throughout life-causes a variety of chronic diseases: duodenal 9 , ,10 and gastric 11 ulcers, gastric cancer, 12 , ,13 and gastric lymphoma. (aappublications.org)
- Extensive scientific research shows that two major etiological factors involved in PUD are infection with H.pylori and ingestion of non-inflammatory drugs (NSAIDs), a careful history of NSAIDs use is also important. (issuu.com)
- Researchers continue to believe that factors such as stress, diet, and heredity play a role in the development of ulcers, since 50% of the population is infected with H. pylori bacteria while only a small percentage have ulcers. (giantmicrobes.com)
- However, researchers have also established a link between H. pylori infection and gastric cancer, which is the 14th most common cause of death worldwide. (news-medical.net)
- Turkish researchers recruited 200 patients infected with H. pylori bacteria. (healthiertalk.com)
- Researchers then again tested the patients for H. pylori four to six weeks after beginning the treatments. (healthiertalk.com)
- Some researchers believe that H. pylori is hereditary. (howstuffworks.com)
- Perhaps more interesting, the researchers found DNA from a type of bacteria that lived in his gut called Helicobacter pylori . (nhpr.org)
- H. pylori juga terkait dengan perkembangan ulkus duodenum dan kanker lambung . (wikipedia.org)
- Helicobacter pylori, or H. pylori, is a type of bacteria that mainly targets the stomach area, specifically the stomach lining and duodenum (the upper-portion of the small intestine). (1000friends-ct.org)
- H. pylori makes its home in the stomach and duodenum, secreting an enzyme that protects it from the onslaught of stomach acid, and then burrows into the mucosal lining. (howstuffworks.com)
- You may have H. pylori bacteria living in your stomach or duodenum right now and not realize it. (howstuffworks.com)
- Helicobacter pylori , a major cause of human gastric disease, is a microaerophilic bacterium that contains neither pyruvate nor 2-oxoglutarate dehydrogenase activity. (asm.org)
- Both POR and OOR are oxygen labile and are likely to be major contributors to the microaerophilic phenotype of H. pylori . (asm.org)
- This may at least partly explain the microaerophilic nature of H. pylori . (asm.org)
- H. pylori is microaerophilic-that is, it requires oxygen, but at lower concentration than in the atmosphere. (wikipedia.org)
- Helicobacter pylori is microaerophilic -that is, it requires oxygen , but at lower concentration than in the atmosphere . (wikipedia.org)
- Helicobacter pylori infection and gastric atrophy are both risk factors for gastric cancer. (bmj.com)
- We aimed to elucidate the natural history of gastric cancer development according to H pylori infection and gastric atrophy status. (bmj.com)
- Development of atrophy and metaplasia of the gastric mucosa are strongly associated with H. pylori infection. (who.int)
- When intraluminal acidity diminishes as a result of gastric atrophy, H.pylori is no longer able to colonize, possibly because of competing organisms. (issuu.com)
- We investigated characteristics of patients falsely seronegative for H. pylori in relation to gastric atrophy. (omicsonline.org)
- Because HP-MP1 induces release of inflammatory cytokines and tumor necrosis factor-α acts as both initiator and tumor promoter, we studied the possible involvement of HP-MP1 in carcinogenesis of H. pylori . (aacrjournals.org)
- Therefore, PAR2 may have an important role in gastric cell adhesion and possibly carcinogenesis associated with H. pylori infection. (springer.com)