Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The physiological renewal, repair, or replacement of tissue.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
The process of bone formation. Histogenesis of bone including ossification.
Renewal or physiological repair of damaged nerve tissue.
Repair or renewal of hepatic tissue.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
Diseases of BONES.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.
The grafting of bone from a donor site to a recipient site.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Bone loss due to osteoclastic activity.
Artificial substitutes for body parts and materials inserted into organisms during experimental studies.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Tumors or cancer located in bone tissue or specific BONES.
Bone lengthening by gradual mechanical distraction. An external fixation device produces the distraction across the bone plate. The technique was originally applied to long bones but in recent years the method has been adapted for use with mandibular implants in maxillofacial surgery.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Restoration of integrity to traumatized tissue.
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.
Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)
A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Hemorrhage into a canal or cavity of the body, such as the space covered by the serous membrane (tunica vaginalis) around the TESTIS leading to testicular hematocele or scrotal hematocele.
The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).
Injuries to the lower jaw bone.
A biocompatible polymer used as a surgical suture material.
Intraoral OSTEOTOMY of the lower jaw usually performed in order to correct MALOCCLUSION.
Fractures of the lower jaw.
The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing.
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Breaks in bones.
Insertion of an implant into the bone of the mandible or maxilla. The implant has an exposed head which protrudes through the mucosa and is a prosthodontic abutment.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.
A group of phosphate minerals that includes ten mineral species and has the general formula X5(YO4)3Z, where X is usually calcium or lead, Y is phosphorus or arsenic, and Z is chlorine, fluorine, or OH-. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
Tumors or cancer of the MANDIBLE.
A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.
The grafting or inserting of a prosthetic device of alloplastic material into the oral tissue beneath the mucosal or periosteal layer or within the bone. Its purpose is to provide support and retention to a partial or complete denture.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.
Elements of limited time intervals, contributing to particular results or situations.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Nonparasitic free-living flatworms of the class Turbellaria. The most common genera are Dugesia, formerly Planaria, which lives in water, and Bipalium, which lives on land. Geoplana occurs in South America and California.
Excision of all or part of the liver. (Dorland, 28th ed)
A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
Fractures of the femur.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.
Preprosthetic surgery involving rib, cartilage, or iliac crest bone grafts, usually autologous, or synthetic implants for rebuilding the alveolar ridge.
Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.
The farthest or outermost projections of the body, such as the HAND and FOOT.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Cells with high proliferative and self renewal capacities derived from adults.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Treatment of muscles and nerves under pressure as a result of crush injuries.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and is essential for PHYSIOLOGICAL ANGIOGENESIS.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
A species of newt in the Salamandridae family in which the larvae transform into terrestrial eft stage and later into an aquatic adult. They occur from Canada to southern United States. Viridescens refers to the greenish color often found in this species.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
The surgical removal of a tooth. (Dorland, 28th ed)
Membranous appendage of fish and other aquatic organisms used for locomotion or balance.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Compounds based on fumaric acid.
Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Surgical insertion of a prosthesis.
Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Introduction of substances into the body using a needle and syringe.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Methods for maintaining or growing CELLS in vitro.
The surgical cutting of a bone. (Dorland, 28th ed)
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Proteins prepared by recombinant DNA technology.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and plays an essential role in EMBRYONIC DEVELOPMENT.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Regeneration of the ventricular myocardium in amphibians. Becker RO, Chapin S, Sherry R. Nature. 1974 Mar 8;248(444):145-7. ... Ultimately, however, the use of electrotherapy for increasing bone healing has not been shown to be effective. Becker believed ... Electrical stimulation of partial limb regeneration in mammals. Becker RO, Spadaro JA. Bull N Y Acad Med. 1972 May;48(4):627-41 ... Mollon B, da Silva V, Busse JW, Einhorn TA, Bhandari M (November 2008). "Electrical stimulation for long-bone fracture-healing ...
... 's Trombone Tribe 75th Birthday Party, JazzCorner; accessed December 22, 2017. Roswell Rudd and Verna Gillis ... Regeneration with Steve Lacy, Misha Mengelberg, Kent Carter, Han Bennink (Soul Note) 1996: The Unheard Herbie Nichols-Vols. 1 ... Rudd brought his Trombone Shout Band to perform at the 4th Festival au Désert in Essakane, Tombouctou Region, Mali. In 2005, he ... Blown Bone (Emanem) 1976: Inside Job with Enrico Rava, Dave Burrell, Stafford James, Harold White (Arista/Freedom) 1978: The ...
From the time of Hippocrates it has been known that bone has considerable potential for regeneration and repair. Nicholas Senn ... Spinal Fusion and Bone Morphogenetic Protein Reddi AH (1997). "Bone morphogenetic proteins: an unconventional approach to ... Early studies by Hari Reddi unraveled the sequence of events involved in bone matrix-induced bone morphogenesis. On the basis ... BMP: The What and the Who BMPedia - the Bone Morphogenetic Protein Wiki Bone+Morphogenetic+Proteins at the US National Library ...
In 1952 the Swedish orthopaedic surgeon, Per-Ingvar Brånemark, was interested in studying bone healing and regeneration. During ... Bone growth around two of the implants, and the formation of calculus, indicates that they were functional as well as esthetic ... Brånemark observed that bone had grown into such close proximity with the titanium that it effectively adhered to the metal. ... While zygomatic implants offer a novel approach to severe bone loss in the upper jaw, it has not been shown to offer any ...
Geiger M, Li RH, Friess W (November 2003). "Collagen sponges for bone regeneration with rhBMP-2". Adv. Drug Deliv. Rev. 55 (12 ... Allegrini S, Yoshimoto M, Salles MB, König B (February 2004). "Bone regeneration in rabbit sinus lifting associated with bovine ... Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bone morphogenetic ... Bone morphogenetic protein 2 has been shown to interact with BMPR1A. Bone morphogenetic protein 2 is shown to stimulate the ...
Known for his studies in the fields of bone and cartilage cell biology, osteoimmunology, and regenerative medicine, Wani is an ... Pathogenesis and Cellular Response as wells as Stem Cells and Regeneration. He resides at the University Campus in Ganeshkkind ... Wani's research focus is in the fields of bone and cartilage cell biology, osteoimmunology, arthritis, stem cell science and ... Born in 1965 in the Indian state of Maharashtra, Mohan Wani graduated in veterinary science from Nagpur Veterinary College and ...
Alderman Sir Charles William Allison CBE, JP, Honorary Freeman of the Borough 1956 William Arthur Bone, combustion engineer, ... author who wrote the historical novel Regeneration, and wife of zoologist David Barker Hugh Cameron, cyclist James Gaddas, ... Labour MP for Southampton Test from 1950-5 and Southampton Itchen from 1955-71 and Speaker of the House of Commons from 1965-71 ...
Bone Marrow Transplant Retrieved on 21 November 2008 Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, ... "Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells, platelate ... Endothelial stem cells are one of the three types of multipotent stem cells found in the bone marrow. They are a rare and ... Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which ...
... and especially as tailored bioerodible materials for the regeneration of living bone. An advantage for this last application is ... Nanofibers and porous constructs of these polymers assist osteoblast replication and accelerate the repair of bone in animal ... Implications of Dipeptide-Substituted Polyphosphazene-Polyester Blend Nanofiber Matrices for Load-Bearing Bone Regeneration". ... Allcock, H. R., Kugel, R. L. (1965). "Synthesis of High Polymeric Alkoxy and Aryloxyphosphonitriles". Journal of the American ...
With Stanley Cowell Regeneration (Strata-East, 1976) With Continuum Mad About Tadd (Palo Alto, 1980) With Miles Davis Miles ... With Curtis Fuller Soul Trombone (Impulse!, 1962) Smokin' (Mainstream, 1972) With Red Garland The Quota (MPS, 1971) 'With Bunky ... 1965: Jam Gems: Live at the Left Bank (Label M - released 2001) - with Freddie Hubbard 1972: The Gap Sealer (Cobblestone) - ... 1965) Big Boss Mann (1970) With Howard McGhee Howard McGhee and Milt Jackson (Savoy, 1948) With Blue Mitchell Blue Soul ( ...
Large scale redevelopment and inner city regeneration has been underway in Leyton for many years, as is also the case in the ... Paleolithic implements and fossil bones show that early man hunted in Leyton. A Roman cemetery and the foundations of a Roman ... Once a traditional, working class area, it is undergoing large-scale regeneration and gentrification, with large numbers of ... has benefited from significant regeneration projects over the past decade. Parks have been spruced up, some new small parks and ...
Many of those aircraft come from the Aerospace Maintenance and Regeneration Center, or "bone yard," at Davis-Monthan Air Force ... which means flying planes that have usually been stripped to the bone and put back together again. The standard check flight ... The squadron continued to train in electronic warfare techniques until beginning to phase down for inactivation in March 1965 ... 15 March 1965 6512th Test Group (later 6510th Test Wing), 15 May 1970 Air Force Flight Test Center, 1 January 1973 6510th Test ...
"Three-dimensional porous bioscaffolds for bone tissue regeneration: fabrication via adaptive foam reticulation and freeze ... 30 (9): 1963-1965. doi:10.1016/j.jeurceramsoc.2010.03.012.CS1 maint: multiple names: authors list (link) Moon Ji-Woong, Hwang ... of fluids through aligned pores has led to the use of freeze casting as a method towards biomedical applications including bone ... 55 (6): 1965-1974. arXiv:1710.04651. doi:10.1016/j.actamat.2006.11.003. Deville, Sylvain (March 2008). "Freeze-Casting of ...
"Bone Marrow Research. 2012: 1-8. doi:10.1155/2012/787414. PMC 3398573. PMID 22830032. Archived from the original on 3 January ... "Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells, platelate ... Bone Marrow Transplant Retrieved on 21 November 2008 *^ Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, ... MSCs have been isolated from placenta, adipose tissue, lung, bone marrow and blood, Wharton's jelly from the umbilical cord,[23 ...
Sharpe, PT; Gallagher, JA; Treffry, TE; Russell, RGG (1982). "Studies of the growth of human bone-derived cells in culture ... Most recently he has been leading research into the possibility of tooth regeneration and the development of new biological- ... "Could an Alzheimer's drug be the key to dental regeneration?: an interview with Paul Sharpe". RegMedNet. Retrieved 8 May 2020 ... "Common origin identified could bring tooth regeneration potential closer". Eurekalert. Retrieved 8 May 2020. " ...
Excavation of the area revealed a large of amount of bones from an extinct species of Bison hence the name of the site. Human ... Fire is necessary to the regeneration of white, red, and jack pines in the area because it opens the forest floor and canopy ... They lived in larger, more permanent settlements and made a variety of stone, wood, and bone tools. Burial mounds from this era ... An overpopulation of white-tailed deer also stunt the regeneration efforts of these pines, as deer browse young pine seedling ...
With Stanley Cowell Regeneration (Strata East, 1976) With Al Grey The Last of the Big Plungers (Argo, 1959) The Thinking Man's ... Trombone (Argo, 1960) With Coleman Hawkins The Saxophone Section (World Wide, 1958) With Milt Jackson Meet Milt Jackson (Savoy ... Verve, 1965) Pop Goes the Basie (Reprise, 1965) Basie Meets Bond (United Artists, 1966) Live at the Sands (Before Frank) ( ...
Allograft offers the best regeneration quality but has lower volume stability. Often a mix of different kinds of bone grafts is ... repair broken bones that have bone loss, and repair broken bone that has not yet healed. Furthermore, bone grafts or ... it is typically sourced from a bone bank. Bone banks also supply allograft bone sourced from living human bone donors (usually ... Xenograft bone substitute has its origin from a species other than human, such as bovine bone (or recently porcine bone) which ...
"Wise Guy" 60-034 had served with the 5th Bomb Wing at Minot AFB and was flown to the Bone Yard in 2008. It is scheduled to go ... "Wise Guy" 60-034 is the second B-52 to be regenerated from the 309th Aerospace Maintenance and Regeneration Group (AMARG) at ... "A B-52H Nicknamed "Wise Guy" Becomes The Second To Ever Come Back From The Bone Yard". Retrieved 28 August 2019. "'Wise Guy' ... It began supporting SAC operations in Southeast Asia with aircraft and personnel in 1965, and increasingly supported these ...
Slow bone regeneration. This is particularly common in patients who smoke intensively during the lengthening process[citation ... Gavriil Ilizarov determined that bone fragments could be carefully pulled apart without disrupting their alignment. These bone ... 2. Solomin L.N. "Bases of osteosynthesis per bone with Ilizarov Apparatus", publishing office ELBI-Spb, 2005 3. Goldreyer M.M ... The apparatus he initially used was modified to support the lengthening of finger (phalanx) bones. The first experiments ...
In addition, satellite cells have the capability to also differentiate into bone or fat. In this way, satellite cells have an ... Activated by stimuli such as injury or high mechanical load, satellite cells are required for muscle regeneration in adult ... "Myogenesis & Muscle Regeneration". WU Neuromuscular. Washington University. Retrieved 2013-03-16. CS1 maint: discouraged ... Yaffe, David; Feldman, Michael (1965). "The formation of hybrid multinucleated muscle fibers from myoblasts of different ...
"BASE Regeneration - Hattersley - Public consultion for Phase 1b and new phase 2" (PDF). Taylor Young. November 2007. Archived ... and Fiona Bone, 32, of Greater Manchester Police there by claiming that there had been an incident of criminal damage. When ... Regeneration in Hattersley is coordinated by Hattersley Neighbourhood Partnership. The city council transferred control of most ... Hattersley is an area receiving major regeneration which includes new properties and additional retail stores. Hattersley is ...
Anthony died from bone cancer in 1991, donating her papers to the University of Rochester. Susan Brownell Anthony II was born ... Anthony II, Susan B. (1972). Survival Kit: A Richer Life through Medication, Interaction & Spiritual Regeneration. New York, ... Though she lived in Deerfield Beach, Anthony died from bone cancer at Hospice-By-The-Sea in Boca Raton on July 8, 1991. Anthony ... She studied theology at Saint Mary's College in Notre Dame, Indiana, earning a PhD in 1965 as one of the first Catholic ...
They are described as the "piranhas of the air", able to strip their victims to the bone in an instant in high enough densities ... Seeing the person he had been for all his regenerations wasn't suited to combat the terror of the Time War, the Eighth Doctor ... They are voracious feeders, eating both organic and inorganic materials ranging from flesh and bone to plant matter to metals ... The Trickster made reference to the Tenth Doctor's upcoming future regeneration and added that the Doctor's first meeting with ...
Regeneration of the bone has been demonstrated to occur, on average, at a rate of 3.2 mm² per month, and studies suggest that ... the issue of bone healing comes into focus. Ostensibly, then, for regeneration to occur, the root canal system must have been ... This is because neutrophils, which are rich sources of PGE2, are present when the majority of rapid bone loss occurs during the ... The predominant mechanism of bone resorption in a periapical lesion, as in the rest of the body, is the performed by ...
This CD is published within the book 'Bone' a Tribute to Steve Lacy. He returned to the United States in 2002, where he began ... Regeneration, with Roswell Rudd, Misha Mengelberg et al. - (1983) Change of Season, with Misha Mengelberg, Han Bennink et al ... Bone : a tribute to Steve Lacy, Gent, Belgium, [2003] - CD attached in book The Beat Suite (Universal Music Jazz France, 2001 [ ... Blown Bone (1976) Area - Maledetti (1976) Area - Event '76 (1976) Company - Company, vol. 5, 6, 7 (1977) Musica Elettronica ...
There is a positive correlation between serum bone alkaline phosphatase (B-ALP) levels and bone formation in humans, although ... a novel mechanism of phosphorus regeneration". Science. 227 (4692): 1338-40. Bibcode:1985Sci...227.1338A. doi:10.1126/science. ... Biliary obstruction Bone conditions Osteoblastic bone tumors Osteomalacia Osteoporosis Hepatitis Cirrhosis Acute cholecystitis ... Also, ALP increases if there is active bone formation occurring, as ALP is a byproduct of osteoblast activity (such as the case ...
The process of regeneration could have symbolised death and rebirth, with all its attendant religious implications. The were- ... "There were a wide number of bones from the marine toad, Bufo marinus". . . at San Lorenzo. Furst (1981), p. 150. Coe 2002, p. ... Coe (1965), p. 123. Pool, p. 112. e.g. Pool, p. 116, or Pohorilenko. See Covarrubias (1986) pg. 99, where he says: "stylistic ... Nearly any representation showing a downturned mouth or cleft head was described as a "were-jaguar". A major 1965 Olmec- ...
J Bone Joint Surg 45:447-461 Seddon, Herbert John. (1951) The Christian Heritage in Medicine. Pp. 16. Inter-Varsity Fellowship ... Holmes, W.; Young, J. Z. (1942). "Nerve regeneration after immediate and delayed suture". Journal of Anatomy. 77 (Pt 1): 63- ... Book review.Sir Herbert Seddon: and the book he nearly didn't write". The Journal of Bone and Joint Surgery. British Volume. 93 ... Sixth report of the Medical Research Council Working Party on Tuberculosis of the Spine". The Journal of Bone and Joint Surgery ...
... and the bone would grow to fill the gap. He also discovered that bone regrows at a fairly uniform rate across people and ... Theoretical and Clinical Aspects of the Regeneration and Growth of Tissue. Translated by Stuart A. Green. Springer, Berlin, ... at the rate of the bone's regrowth, it is possible to extend a bone by a desired amount. The procedure was inspired by a shaft ... by virtue of a framework and pins through the bone, and separates halves of the bone by a tiny amount; by repeating this over ...
Later, when lead-making and bone-processing for soap and china came to be established, they too located in the East End rather ... of the last of the East End docks in the Port of London in 1980 created further challenges and led to attempts at regeneration ... 1965) all being founded or influenced by it.[47] In 1888, the matchgirls of Bryant and May in Bow went on strike for better ...
A common trend in the uses of MCTs is that they are generally used for self-defense mechanisms and in regeneration.[37] ... The bones of cholla that glowed there in their incandescent basketry pulsed like burning holothurians in the phosphorous dark ...
"Inflammation and Regeneration. 36 (24): 24. doi:10.1186/s41232-016-0029-y. PMC 5725936. PMID 29259697.. ... Bone RC, Balk RA, et al. (The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of ... Bone RC, Balk RA, et al. (The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of ... It was discovered in 1965 that a strain of C3H/HeJ mice were immune to the endotoxin-induced shock.[110] The genetic locus for ...
2006: First jaw transplant to combine donor jaw with bone marrow from the patient, by Eric M. Genden (Mount Sinai Hospital, New ... Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era, edited by ... Tissues include bones, tendons (both referred to as musculoskeletal grafts), corneae, skin, heart valves, nerves and veins. ... Bone marrow/Adult stem cell (living-donor and autograft). *Blood transfusion/Blood Parts Transfusion (living-donor and ...
Bone marrow ablation is a process whereby the human bone marrow cells are eliminated in preparation for a bone marrow ... Surface ablation of the skin (dermabrasion, also called resurfacing because it induces regeneration) can be carried out by ...
... to the establishment of Israel as a nation when the bones come together and verses 8 through 14 when life is given to the bones ... commencing at the time of regeneration and continuing until the consummation of salvation. Therefore we encourage all believers ... As such this movement was seen as a fulfillment of the Ezekiel 37 Dry Bones prophecy where verses 1 through 8 apply ... Flannery, Edward H. (1985) [1965]. "An Oasis and an Ordeal". The Anguish of the Jews: Twenty-Three Centuries of Antisemitism ( ...
"Dock regeneration plan boosted". BBC News. 19 December 2002. Retrieved 29 June 2008.. ... Upper Palaeolithic deposits, including bones of Homo sapiens, have been found in local caves,[4] and artefacts dating from the ... As part of Devonport's millennium regeneration project, the Devonport Heritage Trail has been introduced, complete with over 70 ... prepared guitarist Keith Rowe was born in the city before establishing the jazz free improvisation band AMM in London in 1965 ...
Goss, R. J. (1983). Deer Antlers Regeneration, Function and Evolution. Oxford, UK: Elsevier. pp. 43-51. ISBN 9780323140430. .. ... Hall, B. K. (2005). Bones and Cartilage: Developmental and Evolutionary Skeletal Biology. Amsterdam, Netherlands: Elsevier ... featured the talus bone characteristic of all modern even-toed ungulates. This ancestor and its relatives occurred throughout ... 1878 that deer could be bifurcated into two classes on the according to the features of the second and fifth metacarpal bones ...
"Inflammation and Regeneration. 36 (24): 24. doi:10.1186/s41232-016-0029-y. PMC 5725936. PMID 29259697.. ... Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. (June 1992). "Definitions for sepsis and organ failure and ... It was discovered in 1965 that a strain of C3H/HeJ mice were immune to the endotoxin-induced shock.[102] The genetic locus for ... Heppner G, Weiss DW (September 1965). "High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures" ...
Bone-Midland lamps[edit]. In 1956, the inventor Even P. Bone developed a system where a vane in front of each headlight moved ... a tungsten-halogen lamp has a much longer brightness lifetime than similar filaments operating without the halogen regeneration ... The system, called "Bone-Midland Lamps," was never taken up by any car manufacturer.[142] ... Also in the 1965 model year, the Buick Riviera had concealable stacked headlamps. Various Mercedes models sold in America used ...
Antunes, J.L.: Regeneration of the hypothalamic magnocellular system following section of the pituitary stalk and hypothalamic ... Seitz, W., Olarte, M., Antunes, J.L.: Ossifying fibroma of the parietal bone. Neurosurg. 7:513, 1980 ... Antunes, J.L., Carmel, P.W., Zimmerman, E.A., Ferin, M.: Regeneration of the Magnocellular system of the rhesus monkey ... 1959-1965) • João Cid dos Santos (1965-1969) • Jorge Horta (1969-1975) • Torres Pereira (1977-1985) • Ribeiro da Silva (1986- ...
They were joined by Jackson Browne, T Bone Burnett, Elvis Costello, Tom Waits, Bonnie Raitt, Jennifer Warnes, James Burton,[95] ... "Regeneration" with Fred Foster, but it proved no more successful than before. ... It was now made public that the couple had happily remarried and were back together (they had remarried in December 1965).[68] ... His contract with Monument was expiring in June 1965. Wesley Rose, at this time acting as Orbison's agent, moved him from ...
... of the bone marrow, and then enter the circulation. Circulating unactivated platelets are biconvex discoid (lens-shaped) ... The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration. Biomaterials For Treating Skin Loss. Woodhead ... but circulate as intact cells rather than cytoplasmic fragments of bone marrow megakaryocytes.[4]:3 ... Movat HZ, Weiser WJ, Glynn MF, Mustard JF (December 1965). "Platelet phagocytosis and aggregation". The Journal of Cell Biology ...
... of the bone marrow, and then enter the circulation. These unactivated platelets are biconvex discoid (lens-shaped) structures,[ ... The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration. Biomaterials For Treating Skin Loss. Woodhead ... and are not simply cytoplasmic fragments of bone marrow megakaryocytes.[6] ... Movat HZ; Weiser WJ; Glynn MF; Mustard JF (1965). "Platelet phagocytosis and aggregation". J. Cell Biol. 27 (3): 531-43. doi: ...
Monkey Bone (2001) (diproduksi bersama 1492 Pictures). *Behind Enemy Lines (2001) (diproduksi bersama Davis Entertainment) ... Regeneration* (1915). *Cleopatra* (1917). 1920an[sunting , sunting sumber]. *The Iron Horse (1924) ... Those Magnificent Men in Their Flying Machines (1965) (meliputi sebuah 1935-1953 logo) ...
Previously, beaded art was made with bone, seeds, jade, ceramics, or other like materials when now the Huichols have access to ... the shaman is alleged by the Huichols to be able to speak to the gods and ensure the regeneration of the Huichols' souls. ... 1965). "Huichol Sintax book review". Book Review. 67 (5): 1340-1341. doi:10.1525/aa.1965.67.5.02a00560. Retrieved 21 November ...
English writer Stephen Gallagher uses the Wandering Jew as a theme in his 2007 novel The Kingdom of Bones. The Wandering Jew is ... Fig.3.3, p.79 in Todd Presner Muscular Judaism: The Jewish Body and the Politics of Regeneration. Routledge, 2007. The ... Anderson, George K. "The Beginnings of the Legend". The Legend of the Wandering Jew, Brown UP, 1965, pp. 11-37. David Daube, " ... Providence: Brown University Press, 1965. xi, 489 p.; reprint edition ISBN 0-87451-547-5 collects both literary versions and ...
The present local administration, however, has become more tourism-orientated, and it has promoted the regeneration of the ... "Spit Out the Bone" (2016) by Metallica. The Feast of the Madonna della Bruna, held in Matera on 2 July each year, is notable ... 1965) Francesco Rosi's More Than a Miracle (1967) Lucio Fulci's Don't Torture a Duckling (1972) Roberto Rossellini's Anno uno ( ...
As part of the regeneration of Castlemilk in 1999, several public artworks were commissioned and placed at prominent entrances ... bone, bottle glass and a clay pipe bowl that would date the deposit to the 18th century if not earlier. The remains of a stone ... "Case study: Castlemilk Stables, Glasgow". The Prince's Regeneration Trust. Archived from the original on 26 October 2017. ... the area has seen the benefits of a regeneration strategy implemented in the 1980s which has focused on improved housing and ...
A second individual of unusually acute insight was Niccolò Machiavelli, whose prescriptions for Florence's regeneration under ... T-bone steak of Chianina beef cooked over hot charcoal and served very rare with its more recently derived version, the ... 1909-1965), Italian-Israeli mathematician and physicist; Acting President of the Hebrew University of Jerusalem Raphael, ...
I never leave this town till I see the bare bones of this church!' And he is seein' 'em!" It was rumored he started the fire ... in Saint Petersburg had an agenda for reform and joined with Christian Socialists to form the Union of Church Regeneration. " ... Polski Narodowy Kościól Katolicki w Stanach Zjednoczonych Ameryki w latach 1897-1965 jego spoleczne unwarunkowania i spoleczne ...
Regeneration work was completed in July 2009 on Waterloo Road in South Shore that transformed the area into a modern shopping ... Funny Bones (1995) starring Lee Evans and Oliver Platt and directed by St. Annes born Peter Chelsom, and The Parole Officer ( ... The numerous urban regeneration projects, the property prices which are among the most affordable in the UK, and the high ... The regeneration company behind much of the towns current and future development, ReBlackpool, are working with Blackpool ...
Linda A. Brown, 'Planting the Bones: Hunting Ceremonialism at Contemporary and Nineteenth-Century Shrines in the Guatemalan ... and thus restore them to their supernatural Owners for regeneration. They should also respect certain hunting taboos, such as ... bone'). The loss of one or more souls results in specific diseases (generically called 'soul-loss', 'fright', or susto). In ... traditional Maya hunters have the duty to preserve the skulls and bones of their booty, deposit these periodically in hunting ...
Finally, these peptides even have the capability to increase the rate of tissue regeneration, as seen with the frog in which ... This condition largely increases the risk of developing cancers like breast cancer, bone cancer, and soft tissue sarcomas. ... Toolan, H.W., Saunders, E.L., Southam, C.M., Moore, A.E. and Levin, A.G. (1965) H-l virus viremia in the human. Proc. Sot. Exp ... Toolan, H.W. and Ledinko, N. (1965) Growth and cytopathogenicity of H-viruses in human and simian cell cultures. Nature 208, 8 ...
Mice are known to suffer from rapid loss of muscle and bone mass after as little as 12 days of space flight exposure. The mice ... The newts had part of their front limbs amputated, to study the rate of regeneration in space, knowledge to understand human ... In the absence of gravity, astronauts are subject to a decrease in muscle, bone, and tendon mass. "Although, we're not out to ... China launched mice and rats in 1964 and 1965, and two dogs in 1966.[citation needed] During the Voskhod program, two Soviet ...
Bede made references to harp-playing, and abundant archeological evidence has been found of wooden flutes, bone flutes, ... Durham County Council's Cabinet member for economic regeneration said that the funds would help the partners in Bishop Auckland ... Economic Development and Construction Act 2009 with powers over economic development and regeneration. In November 2018, ... where the world's first hover mower was built in 1965. In West Auckland, Potters Europe make road reflectors. GlaxoSmithKline ...
... to assess the efficacy of EMD in combination with autogenous bone graft compared with the use of EMD alone for the regeneration ... All randomized controlled trials (RCTs) comparing a combination of EMD and autogenous bone graft with EMD alone for the ... the obtained results indicate that the combination of enamel matrix derivative and autogenous bone graft may result in non- ... with an autogenous bone graft in periodontal regeneration has been proposed to improve clinical outcomes, especially in case of ...
Regeneration of the ventricular myocardium in amphibians. Becker RO, Chapin S, Sherry R. Nature. 1974 Mar 8;248(444):145-7. ... Ultimately, however, the use of electrotherapy for increasing bone healing has not been shown to be effective. Becker believed ... Electrical stimulation of partial limb regeneration in mammals. Becker RO, Spadaro JA. Bull N Y Acad Med. 1972 May;48(4):627-41 ... Mollon B, da Silva V, Busse JW, Einhorn TA, Bhandari M (November 2008). "Electrical stimulation for long-bone fracture-healing ...
A) Dissected and prepared mouse femur for in situ incubation of bone cells (bone marrow [bm]) within the femoral bone cavity. ( ... of bone cysts and during osteonecrosis.15 Encouraging are also studies that report the beneficial use of bone marrow MSCs, bone ... degrading bone) and lining cells (involved in coupling bone resorption to bone formation). In cartilage tissue chondroblasts ( ... Regeneration activity - including osteoinducibility [potency of the MSC to stimulate towards the bone-forming cell lineage ( ...
Geiger M, Li RH, Friess W (November 2003). "Collagen sponges for bone regeneration with rhBMP-2". Adv. Drug Deliv. Rev. 55 (12 ... Allegrini S, Yoshimoto M, Salles MB, König B (February 2004). "Bone regeneration in rabbit sinus lifting associated with bovine ... Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bone morphogenetic ... Bone morphogenetic protein 2 has been shown to interact with BMPR1A. Bone morphogenetic protein 2 is shown to stimulate the ...
Spontaneous bone regeneration in an open segmental fracture of the forearm with extruded middle segment. Cureus 2016; 8 (09) ... The extruded bones were a segment with a length of 5.5 cm and a cortical bone with a length of 4 cm. The extruded fragments ... Traumatic femoral bone loss. J Bone Joint Surg Br 1965; 47: 106-110 ... A 6-year-old boy presented with a Gustilo type IIIB open fracture on his left leg with a segment of bone loss in his tibia. The ...
In bone repair, the plaster is mixed with a non-bioresorbable calcium source, ... Plaster of Paris is employed to form implants as well as a bioresorbable scaffold for implants and bone repair in animals. ... Coetzee, Andries S., "Regeneration of Bone in the Presence of Calcium Sulfate," Arch Otolaryngol., 106, 405-409 (1980). .. ... It may also be used as a substitute for bone grafts for massive bone loss as a result of trauma, tumor or resorption and for ...
The present study aimed to evaluate the influence of porous silk scaffolds on rat bone marrow stem cells (BMSCs) by lenti-GFP ... silk scaffolds provide a suitable niche to maintain long survival and function of the implanted cells for bone regeneration. ... The number of cells seeded within silk scaffolds in rat cranial bone defects increased from 2 days to 2 weeks after ... Silk fibroin, as a natural protein polymer, has unique properties for tissue regeneration. ...
... as bone inducers, a whole protein family of growth factors connected to a wide ... More than 40 years after the discovery of Bone Morphogenetic Proteins (BMPs) ... Their development and role in todays clinical practice, especially in the field of bone regeneration, will be a main focus of ... Even though earlier studies in the field of bone regeneration are known, Dr. Marshall Raymond Urist, an orthopedic surgeon, ...
Geiger M, Li RH, Friess W (November 2003). "Collagen sponges for bone regeneration with rhBMP-2". Adv. Drug Deliv. Rev. 55 (12 ... See also: Bone morphogenetic protein § Clinical uses. Bone morphogenetic protein 2 is shown to stimulate the production of bone ... Allegrini S, Yoshimoto M, Salles MB, König B (February 2004). "Bone regeneration in rabbit sinus lifting associated with bovine ... BMP-2 like other bone morphogenetic proteins,[2] plays an important role in the development of bone and cartilage. It is ...
phase bone to bring joint neurons! These begin 20 to 30 free cryptography in c and in and cover intelligence s nt to the ... The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration. experiments For Treating Skin free cryptography in c ... What can I satisfy to provide this in the free cryptography in c and? If you make on a first bone, like at safety, you can be ... As bone of this nostro, the CNSC, through its Safeguards Support Program, is the plant in regarding online variants 1b or ...
Periodontitis and all periodontal diseases are bacterial infections that destroy the attachment fibers and supporting bone. ... The application of bone morphogenetic proteins to periodontal and peri-implant tissue regeneration: A literature review. J ... Bone Morphogenetic Proteins: Periodontal Regeneration. N Am J Med Sci. Mar 2013; 5(3): 161-168. ... Conventional treatment procedures may be ineffective in achieving bone regeneration, leaving both the clinician and the patient ...
Calcium phosphate has been utilized to improve bone regeneration in ways such as increasing osteoconductivity for bone ingrowth ... It can be directly contributed to bone regeneration process or assist in the use of other biomaterials. Therefore, it is widely ... Calcium phosphate has been used for bone regeneration in various forms such as coating, cement and scaffold based on its unique ... Many experiments have been performed using biomaterials in vivo and in vitro to promote and understand bone regeneration. Among ...
Bone, 36:267-75, 2005. Gothlin, G. & Ericsson, J. L. E. The osteoclast: review of ultrastructure, origin, structure-function ... The periodontal ligament tissue is thought to play an important part in the regeneration of the periodontium, but the precise ... Minkin, C. Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif. Tissue. Int ... The periodontal ligament is the connective tissue localized between the root of the tooth and the alveolar bone, and is known ...
Bone regeneration in a rabbit critical femoral defect by means of magnetic hydroxyapatite macroporous scaffolds. J Biomed Mater ... Enhanced bone regeneration and visual monitoring via superparamagnetic iron oxide nanoparticle scaffold in rats. J Tissue Eng ... Li Y, Ye D, Li M, Ma M, Gu N. Adaptive materials based on iron oxide nanoparticles for bone regeneration. ChemPhysChem 2018; 19 ... Finally, the mechanism of magnetic response materials to promote bone regeneration was introduced. The combination of magnetic ...
This procedure is indicated when there is no sufficient bone for implantation, or in the case of optimal implant installation ... GBR can be performed before implant placement, when there is not enough bone for initial stability of implants and less ... This literature review discusses the background, principles of GBR, the materials used in GBR (types of membranes and bone ... Guided bone regeneration (GBR) is a reconstructive procedure of alveolar ridge using membranes. ...
Synthetic bone grafts and demineralized bone matrices (DBMs) fall under Class II and require a 510(k) for market clearance, ... Drug-device combination bone grafts are Class III and require an investigational device exemption (IDE) clinical trial followed ... Currently, there are only two PMA-supported Class III drug-device bone graft substitutes with Level I data that demonstrate ... This chapter is focused on the USFDA regulation and the related efficacy evidence of bone graft materials, especially Class III ...
Bone regeneration after enucleation of mandibular cysts: Comparing autogeneous grafts from tissue-engineeered bone and iliac ... Bone Engineering: Allogenic and Alloplastic Bone Transplants vitalized by Osteoblast-like Cells. Language: English ... The mitogene effect of demineralised bone matrix can be attributed to the existence of various growth factors in the bone ... Bone formation by autoinduction. Science 1965;150:893-899.. *Wozney JM. The bone morphogenetic protein family and osteogenesis ...
Reference: Zenkevich G.D., Glycoproteins in the blood serum during the process of bone tissue regeneration after fractures and ... Glycoproteins in the blood serum during the process of bone tissue regeneration after fractures and transplantation. ... 1965(Vol:11). Issue:6. Issue:5. Issue:4. Issue:3. Issue:2. Issue:1. ...
J Bone Joint Surg 1993; 75A: Chondrogenesis in periosteal transplants. The repair of major tial for cartilaginous regeneration ... Pidhorz L E, Urban R M, Jacobs J J, Sumner D R, Galante J O. A quantitative study of bone and soft tissues in cementless porous ... Fluid pressure causes bone resorption in a rabbit model of prosthetic loosening cheap maxalt 10 mg with mastercard. Schmalzried ... On the bone tissue response to titanium implants, PhD Thesis, University of Gothenburg, Gothenburg, Sweden, 1991. Carlsson L V ...
First, we tested CS-Platelet in heterotopic (muscle) and orthotopic (bone) bone regeneration bioassays. We then utilized CS- ... where regeneration of bone was needed. The heterotopic bioassay showed formation of bone within the muscular tissue at the site ... size defect showed that only CS-Platelet and recombinant human BMP2 were able to induce a significant regeneration of bone. A ... We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets may initiate a series of ...
Bone morphogenetic proteins in human bone regeneration. Eur J Endocrinol. 2000;142:9-21.View ArticleGoogle Scholar. ... Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res. 1998;43:356-64.View ... which are used in bone regeneration because of their similarity to inorganic bone components such as hydroxyapatite (HA). Many ... J Bone Joint Surg Am. 2001;83A:98-103.Google Scholar. *. Kao ST, Scott DD. A review of bone substitutes. Oral Maxillofac Surg ...
Tissue Banking of bone allografts used in periodontal regeneration. J Periodontol. 2001;72(6):834-838. ... Fugazzotto PA, Shanaman R, Manos T, Shectman R. Guided bone regeneration around titanium implants: report of the treatment of ... Comparison of bone graft materials. Part I. New Bone formation with autografts and allografts determined by Strontium-85. J ... Comparison of bone graft materials. Part II. New bone formation with autografts and allografts: a histological evaluation. J ...
Jenne CN, Urrutia R, Kubes analysis( June 2013). free-associations: emerging Limits, ebook hani hamrita como é, and bone . ... The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration. contents For Treating Skin system. Movat HZ, Weiser WJ ... The most comprehensive ebook hani hamrita como for verified or an published bone condition completes Thrombin device. reports ... é grande o of key plants and descent of such Role and provides us with bone and safety on wider primary events white as robot ...
"Bone Marrow Research. 2012: 1-8. doi:10.1155/2012/787414. PMC 3398573. PMID 22830032. Archived from the original on 3 January ... "Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells, platelate ... Bone Marrow Transplant Retrieved on 21 November 2008 *^ Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, ... MSCs have been isolated from placenta, adipose tissue, lung, bone marrow and blood, Whartons jelly from the umbilical cord,[23 ...
Multiple skull fractures were noted grossly and on x-ray examination involving both temporal bones, the left parietal bone, and ... The fact that he was "receiving physical therapy for a nerve regeneration pain" does not match Dr. Peacocks statement that ... Bones were broken in his left foot and in his skull: Multiple ecchymoses [discoloration from bleeding into the skin] and ... She maintains that Jarrell had no broken bones or lacerations; and repeats this in 1967 when describing the death of their cat ...
Based on our preliminary positive clinical results with use of cultured bone marrow-derived multipotent mesenchymal stem/ ... Currently, there are two approaches to bone regene-ration. The first one is based on the delivery of high doses of bone ... Thereby, the next step in bone regeneration was the use of immunomodulatory allogeneic cultured osteoprogenitor bone marrow- ... Gene transfer approaches to enhancing bone healing. In: Bone Regeneration and Repair. JR Lieberman, GE Friedlaender, eds. ...
Brown K.L., Cruess R.L. Bone and cartilage transplantation in orthopaedic surgery // J. Bone Joint Surg. (Am.). 1982. Vol.64. P ... Akizuki S., Yasukawa Y., Takizawa T. Does arthroscopic abrasion arthroplasty promote cartilage regeneration in osteoarthritic ... Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo // Clin. OrthoP 1980. vol. 151. P 294-307 ... J Bone Joint Surg Br. 1961; 43:752-757.. 70. Peterson I. International experience with autologus chondrocyte transplantation ...
From the time of Hippocrates it has been known that bone has considerable potential for regeneration and repair. Senn, a ... Early studies by Hari Reddi unraveled the sequence of events involved in bone matrix-induced bone morphogenesis (Reddi, 1972). ... Using a battery of bioassays for bone formation, a systematic study was undertaken to isolate and purify putative bone ... Urist made the key discovery that demineralized, lyophilized segments of bone induced new bone formation when implanted in ...
Strontium enhances BMP-2 mediated bone regeneration in a femoral murine bone defect model.. J Biomed Mater Res B 2019 in press ... Strontium enhances BMP-2 mediated bone regeneration in a femoral murine bone defect model.. J Biomed Mater Res B 2020, 108B, ... step stem cell therapy improves bone regeneration compared to concentrated bone marrow therapy.. J Orthop Res 2019, 37, 1318 - ... Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the ...
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. ... Mineralized bone was also lost. The cytokine CCL3, known to be involved in bone loss, was increased in AML cells in mice and ... The normal bone marrow anatomy (here using the example of the femur) is composed of different types of bone, blood vessels and ... It was shown that PTHinduced bone remodeling led to a release of su-praphysiological levels of TGFβ1 from the bone matrix ...
  • Urist MR (1965). (wikipedia.org)
  • Even though earlier studies in the field of bone regeneration are known, Dr. Marshall Raymond Urist, an orthopedic surgeon, made the landmark discovery in 1965. (igi-global.com)
  • Urist described his elusive observation with the following words: "Wandering histiocytes, foreign body giant cells, and inflammatory connective-tissue cells are stimulated by degradation products of dead matrix to grow in and repopulate the area of an implant of decalcified bone" (Urist, 1965). (igi-global.com)
  • Since Marshall Urist described bone formation by autoinduction [ 4 ] and by purified bone morphogenetic proteins (BMPs) from bone [ 5 ], researchers have focused their investigations on techniques for delivering BMPs in order to induce bone regeneration. (biomedcentral.com)
  • BMPs were first proposed as bone morphogenes by Urist in 1965 [2]. (exp-oncology.com.ua)
  • They were originally recognized for their ability to induce endochondral bone formation ( Urist, 1965 ). (wikidot.com)
  • The biological basis of bone morphogenesis was shown by Marshall R. Urist. (wikidot.com)
  • Urist made the key discovery that demineralized, lyophilized segments of bone induced new bone formation when implanted in muscle pouches in rabbits. (wikidot.com)
  • This seminal discovery was published in 1965 by Urist in Science ( Urist, 1965 ). (wikidot.com)
  • Marshall Urist proposed the name "Bone Morphogenetic Protein" in the scientific literature in the Journal of Dental Research in 1971 ( Urist, 1971 ). (wikidot.com)
  • In 1965, the BMP was isolated by Marshal Urist, who showed that this protein extracted from bone narrow could induce bone neoformation when implanted in sites without bone cells. (bvsalud.org)
  • A proteína óssea morfogenética (BMP) foi identificada, em 1965, por um norte-americano chamado Marshal Urist, que mostrou que essa proteína, extraída da cortical óssea bovina, poderia induzir a formação de novo osso quando implantada em locais não ósseos. (bvsalud.org)
  • The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)
  • Based on the historical work of Dr. Urist since 1965 [ 1 ], DDM itself can be defined as acid insoluble, microporous, type I collagenous scaffold that has several non-collagenous growth factors such as BMPs, PDGF and FGF2 in addition to a mineral phase [ 2 , 3 , 4 ]. (intechopen.com)
  • Bone morphogenic proteins (BMPs) were discovered in 1965 by Urist [ 1 ], revealing their ability to differentiate undifferentiated osteogenic progenitor cells. (springeropen.com)
  • 12,13 Urist 14 described heterotopic bone formation after implantation of DBM into mouse muscle pouches, and researchers then seriously considered DBM as a potential bioimplant for osseous repair. (jcda.ca)
  • Tissue-engineered bone is a relatively new strategy to treat massive bone defects, instead of the use of autologous bone grafts which present drawbacks [1] - [2] . (plos.org)
  • This literature review discusses the background, principles of GBR, the materials used in GBR (types of membranes and bone grafts), success criteria and long term results of GBR. (ac.ir)
  • Guided bone regeneration using bone grafts and collagen membranes. (ac.ir)
  • A new approach in therapy is the application of tissue engineered bone grafts. (quintessenz.de)
  • Synthetic bone grafts and demineralized bone matrices (DBMs) fall under Class II and require a 510(k) for market clearance, generally on the basis of an animal study. (intechopen.com)
  • Drug-device combination bone grafts are Class III and require an investigational device exemption (IDE) clinical trial followed by a premarket approval (PMA) application with the FDA to review safety and effectiveness. (intechopen.com)
  • Autologous bone grafts are routinely used, but they have drawbacks such as limited quantity and accessibility [ 1 ] and donor site morbidity. (biomedcentral.com)
  • Recently, a lot of studies have been looking for bone regeneration using BMPs without bone grafts. (bvsalud.org)
  • The present study it was concluded that the bone morphogenetic protein induces bone neoformation, being an alternative as a substitute to bone grafts and that new carrier discovery is necessary to smooth stability of this carriers in receptor site. (bvsalud.org)
  • Recipients of bone grafts (allogenic or xenogenic bone material). (springeropen.com)
  • Particulated autogenous bone grafts produced less new bone initially (after 2 weeks), but the amount of bone produced by these grafts gradually increased, to levels comparable to the BMP-containing bioimplants by 8 weeks. (jcda.ca)
  • BMP-containing bioimplants demonstrated promise as alternatives to autogenous bone grafts for sinus-augmentation procedures. (jcda.ca)
  • 2 Autogenous bone grafts are considered the gold standard for the repair of most osseous defects, 3,4 including augmentation of the maxillary sinus. (jcda.ca)
  • Numerous studies have compared the effectiveness of these alternatives as potential replacements for autogenous bone grafts. (jcda.ca)
  • Given the constraints of both autogenous bone grafts and bone allografts, synthetic bioimplants containing bone morphogenetic proteins (BMPs) have garnered interest as being potentially suitable for osseous repair in clinical settings. (jcda.ca)
  • Free gingival grafts to increase the keratinised tissue results in a signifi cant decrease of the bleeding on probing and gingival index, probing depths, higher marginal bone levels and reduced plaque scores when compared to maintenance sites with no grafting. (regeneration-expert.com)
  • Connective tissue grafts have a positive eff ect on reduction of the marginal bone levels, but result in no signifi cant improvement in the bleeding or plaque indices or probing depths. (regeneration-expert.com)
  • Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals. (springer.com)
  • The periosteum of the proximal and distal ends of the femur was cauterized circumferentially, and excised portions were used in the contralateral femur as autologous bone grafts. (biomedcentral.com)
  • These data suggest that autologous bone grafts in combination with MSCs benefit difficult cases which cannot be treated with autologous bone grafts alone. (biomedcentral.com)
  • For bone defects or non-union, autologous bone grafts are used daily in clinical practice. (biomedcentral.com)
  • We hypothesized that the combination of autologous bone grafts with FGF-2 or MSCs could achieve bone union even under quite poor conditions compared to conventional bone grafts. (biomedcentral.com)
  • 1 Calvarial or iliac bone grafts, mental nerve displacement, and sinus lift procedures are often used to overcome the initially unfavorable anatomical and mechanical conditions. (allenpress.com)
  • The combination of enamel matrix derivative (EMD) with an autogenous bone graft in periodontal regeneration has been proposed to improve clinical outcomes, especially in case of deep non-contained periodontal defects, with variable results. (mdpi.com)
  • The aim of the present systematic review and meta-analysis was to assess the efficacy of EMD in combination with autogenous bone graft compared with the use of EMD alone for the regeneration of periodontal intrabony defects. (mdpi.com)
  • All randomized controlled trials (RCTs) comparing a combination of EMD and autogenous bone graft with EMD alone for the treatment of periodontal intrabony defects were included. (mdpi.com)
  • Peltier, Leonard F., "The Use of Plaster of Paris to Fill Defects in Bone", Clin. (patents.com)
  • The present study aimed to evaluate the influence of porous silk scaffolds on rat bone marrow stem cells (BMSCs) by lenti-GFP tracking both in vitro and in vivo in cranial bone defects. (plos.org)
  • The number of cells seeded within silk scaffolds in rat cranial bone defects increased from 2 days to 2 weeks after implantation, followed by a decrease at eight weeks. (plos.org)
  • The combination of magnetic field treatment methods will bring significant progress to regenerative medicine and help to improve the treatment of bone defects and promote bone tissue repair. (eurekaselect.com)
  • Dahlin C, Linde A, Gottlow J, Nyman S. Healing of bone defects by guided tissue regeneration. (ac.ir)
  • Dahlin C, Gottlow J, Linde A, Nyman S. Healing of maxillary and mandibular bone defects using a membrane technique. (ac.ir)
  • The search for suitable techniques and materials for the reconstruction of bone defects is a primary goal in many clinical disciplines. (quintessenz.de)
  • This study showed that CS-Platelet is a novel biomaterial able to induce formation of bone in heterotopic and orthotopic sites, in orthotopic critical size bone defects, and in various clinical situations. (biomedcentral.com)
  • The healing of bone fractures, especially critical size defects, poses a great challenge in medicine. (biomedcentral.com)
  • Based on our preliminary positive clinical results with use of cultured bone marrow-derived multipotent mesenchymal stem/stromal cells in traumatology, our aim was to develop living three-dimensional tissue-engineered bone equivalent transplantation technology for restoration of critical sized bone defects caused by combat related high energy trauma. (exp-oncology.com.ua)
  • Bone defect treatment with bone equivalent application was fully completed in 39 combat-injured with 42 defects. (exp-oncology.com.ua)
  • The gold standard for extended bone defects' treatment is autologous osteoplastic surgery. (exp-oncology.com.ua)
  • In Dentistry autogenous bone is the most useful tissue used in pre-prosthetic surgery and rehabilitation treatment of bone defects, thereby contributing to the function and aesthetics 8 . (bvsalud.org)
  • The aim of this study is to quantitatively evaluate the effect of rhBMP-2 for repair of bone defects after cyst enucleation using the osteogenesis index (OI). (springeropen.com)
  • The application of rhBMP-2 after maxillofacial cyst enucleation accelerated new bone formation in the bone defects. (springeropen.com)
  • Thus, the use of rhBMP-2 in combination with ACS may be considered an alternative to conventional bone grafting in some patients with postoperative bone defects. (springeropen.com)
  • Bone defects in the oral and maxillofacial region have many different causes, such as infection, trauma, lesions, or invasive surgery. (springeropen.com)
  • Bone allografts, such as demineralized bone matrix (DBM), were first used to reconstruct skull defects in dogs more than 100 years ago. (jcda.ca)
  • Our systematic studies in P. ursinus with translational hTGF-β 3 in large cranio-mandibulo-facial defects in humans are now requesting the re-evaluation of " Bone: formation by autoinduction " in primate models including humans. (frontiersin.org)
  • Although the contribution of fibroblast growth factor (FGF)-2 and mesenchymal stromal cells (MSCs) to bone formation is well known, few studies have investigated the combination of an autologous bone graft with FGF-2 or MSCs for large bone defects. (biomedcentral.com)
  • Although autologous bone grafting is the gold standard, its ability to achieve bone union under relatively poor conditions in the recipient site such as large bone defects or atrophic non-union is not promising. (biomedcentral.com)
  • In critical-sized segmental defects in the femurs of adult athymic rats, there was significantly more new bone formation at 12 weeks, and the bone formed was stronger, in defects treated with mesenchymal stem cell-loaded ceramic scaffolds than in scaffolds without MSCs [ 6 ]. (biomedcentral.com)
  • BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. (wikipedia.org)
  • As an adjuvant to allograft bone or as a replacement for harvested autograft, bone morphogenetic proteins (BMPs) appear to improve fusion rates after spinal arthrodesis in both animal models and humans, while reducing the donor-site morbidity previously associated with such procedures. (wikipedia.org)
  • More than 40 years after the discovery of Bone Morphogenetic Proteins (BMPs) as bone inducers, a whole protein family of growth factors connected to a wide variety of functions in embryonic development, homeostasis, and regeneration has been characterized. (igi-global.com)
  • The first one is based on the delivery of high doses of bone morphogenetic and other factors to the defect zone, such as autologous platelet concentrate or recombinant bone morphogenetic proteins (BMPs). (exp-oncology.com.ua)
  • Bone Morphogenetic Proteins (BMPs) are a family of ligands that belong to the Transforming Growth Factor β (TGFβ) superfamily ( Wozney, 1989 ). (wikidot.com)
  • Using a battery of bioassays for bone formation, a systematic study was undertaken to isolate and purify putative bone morphogenetic proteins. (wikidot.com)
  • Within their limits, the obtained results indicate that the combination of enamel matrix derivative and autogenous bone graft may result in non-significant additional clinical improvements in terms of CALgain, PDred, and RECinc compared with those obtained with EMD alone. (mdpi.com)
  • This chapter is focused on the USFDA regulation and the related efficacy evidence of bone graft materials, especially Class III drug-device combination products for use in the spine. (intechopen.com)
  • Currently, there are only two PMA-supported Class III drug-device bone graft substitutes with Level I data that demonstrate equivalence to autograft for safety and effectiveness in spine: Infuse® (rhBMP-2) and i-FACTOR (P-15 peptide). (intechopen.com)
  • The ideal bone graft substitute for spinal fusion would have the safety and effectiveness of autograft when used by itself, be supported by quality published clinical evidence, and be available at a reasonable cost. (intechopen.com)
  • A large reason for these challenges is that the regulatory pathways and required evidence leading to FDA approval for spinal bone graft substitutes vary widely. (intechopen.com)
  • One possible explanation for this is that US Food and Drug Administration (FDA) regulations require that all human bone allograft products be labeled with unique alphanumeric identification codes that allow each manufacturer to record and track the graft material to its recipient (and vice versa). (cdeworld.com)
  • As a result, a variety of bone graft materials and osteogenic factors have been examined but have not led to ideal alternatives or substitutes, so relevant studies are ongoing. (springeropen.com)
  • In many cases, after removal of the cyst, bone grafting is performed using a particle-type bone graft material. (springeropen.com)
  • Although many studies have already shown the bone regenerative effects of rhBMP-2, most of these were in vitro or animal studies in which rhBMP-2 was added to other bone graft materials, and some of the clinical reports involved non-quantitative methods. (springeropen.com)
  • The maxillary sinus is surrounded by highly vascular tissue, 1 making it an ideal site to receive a bone graft or, in the future, tissue-engineered constructs. (jcda.ca)
  • Alternatives to Autologous Bone Graft in Alveolar Cleft Reconstruction: The State of Alveolar Tissue Engineering J Craniofac Surg. (usc.edu)
  • An autologous bone graft contains cells including bone marrow mesenchymal stem cells (MSCs) and several growth factors which induce bone formation in a native bone structure. (biomedcentral.com)
  • This raises the possibility that augmentation of these factors could enhance the ability of a graft to achieve bone union even under poor conditions. (biomedcentral.com)
  • This protocol also represents a second chance for patients who have experienced complete implant loss and/or bone graft failure. (allenpress.com)
  • Apparently, the physiological roles of BMPs have expanded their range from bone growth induction and connective tissue regeneration to cancer diagnosis/treatment and cardiovascular disease prevention. (igi-global.com)
  • BMPs interact with specific receptors on the cell surface, referred to as bone morphogenetic protein receptors (BMPRs). (wikidot.com)
  • In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. (bvsalud.org)
  • Following studies have reported BMPs to have crucial role in the formation of bone and cartilage. (alliedacademies.org)
  • BMPs induce pluripotent mesenchymal stem cells to differentiate into bone-forming osteoblasts. (jcda.ca)
  • Bioreactors pre-loaded with recombinant human Noggin (hNoggin), a BMPs antagonist, show down-regulation of BMP-2 and other profiled osteogenic proteins' genes resulting in minimal bone formation. (frontiersin.org)
  • The induction of bone formation by hTGF-β 3 is via the BMPs pathway and it is thus blocked by hNoggin. (frontiersin.org)
  • Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. (wikipedia.org)
  • 14 DBM also contains noncollagenous proteins (NCPs), which may be important markers in bone formation. (jcda.ca)
  • Osteoinductive proteins from the bone matrix recruit stem cells at a distance from the microcracks that participate in the bone remodeling process. (allenpress.com)
  • Unprecedented is the property of these biopolymers to deliver high-energy phosphate in the extracellular space to promote anabolic processes including extracellular matrix synthesis in bradytrophic tissues such as cartilage and mineralized bone. (rsc.org)
  • In addition to his ERC Advanced Grant and further European projects, he has received three ERC-PoC Grants on repair/regeneration of bone, cartilage and blood vessels. (rsc.org)
  • Implants made of synthetic polymers, ceramics or metals as well as allogenic materials like collagen or cartilage are used for bone grafting. (quintessenz.de)
  • It was shown to be important in the development of the heart, central nervous system, and cartilage, as well as post-natal bone development. (wikidot.com)
  • Growth takes place at the epiphyseal growth plate of long bones by a finely balanced cycle of cartilage growth, matrix formation and calcification of cartilage that acts as a scaffold for bone formation. (unu.edu)
  • However, there is an increasing body of evidence which demonstrates that factors produced locally in bone and cartilage, or trapped within hard tissue matrix, may play a critical role in regulating normal and pathological skeletal growth and remodelling. (unu.edu)
  • Bone is an organ composed of cortical and trabecular bone, cartilage, haemopoetic and connective tissues (Ham, 1974). (unu.edu)
  • Effect of mechanical force on cartilage repair and regeneration. (miami.edu)
  • Traumatic femoral bone defect reconstruction with an autoclaved autologous femoral segment. (thieme-connect.com)
  • By summarizing the properties of calcium phosphate and its research direction, we hope that calcium phosphate can contribute to the clinical treatment approach for bone defect and disease. (biomedcentral.com)
  • In vivo study of a bioactive nanoparticle-gelatin composite scaffold for bone defect repair in rabbits. (eurekaselect.com)
  • New nano-hydroxyapatite in bone defect regeneration: A histological study in rats. (eurekaselect.com)
  • Bone regeneration in a rabbit critical femoral defect by means of magnetic hydroxyapatite macroporous scaffolds. (eurekaselect.com)
  • We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets may initiate a series of biological processes that culminate in bone regeneration. (biomedcentral.com)
  • Results of a quantitative orthotopic bioassay based on the rat calvaria critical size defect showed that only CS-Platelet and recombinant human BMP2 were able to induce a significant regeneration of bone. (biomedcentral.com)
  • Differing from the approaches seen to date, in our work we hypothesized that nourishing a bone defect with calcium, a major inorganic constituent of bone, and with a large amount of activated platelets, representing a component of wound healing, may initiate a series of biological processes that culminate in bone regeneration. (biomedcentral.com)
  • Bone defect restoration was observed 5-6 months post-op. (exp-oncology.com.ua)
  • The developed biotechnology of living three-dimensional tissue-engineered bone equivalent transplantation with overall effectiveness 90.4% allows restoring the bone integrity, forming new bone tissue in a site of bone defect, and significantly reducing the rehabilitation period of a patient. (exp-oncology.com.ua)
  • The choice of the method of plastic of the bone defect depends on its location and size. (exp-oncology.com.ua)
  • Biomaterials can be defined as any material that acts replacing a lost bone defect and its function. (bvsalud.org)
  • Biomaterials can be defined as "any material, natural or synthetic, that acts in tissues/organs in order to replace the bone defect lost and s function" 13 . (bvsalud.org)
  • ACS alone or rhBMP-2 plus ACS was used for bone defect repair. (springeropen.com)
  • Effects of strontium-doped β-tricalcium scaffold on longitudinal nuclear factor kappa-beta (NF-κB) and vascular endothelial growth factor receptor-2 (VEGFR-2) promoter activities during bone healing in critical size bone defect mice model. (ukaachen.de)
  • We studied an atrophic non-union model with a large bone defect, created by resecting a 10-mm section from the center of each femoral shaft of 12-week-old Sprague-Dawley rats. (biomedcentral.com)
  • The purpose of this study was to verify whether bone union can be obtained using the combination of autologous bone grafting with FGF-2 or MSCs in an atrophic non-union model of a large bone defect in the rat. (biomedcentral.com)
  • and the Laboratory for Experimental Surgery Davos, known today as ARI, where he worked under director Herbert Fleisch (1964-1965). (aofoundation.org)
  • Bone morphogenetic protein 2 has been shown to interact with BMPR1A. (wikipedia.org)
  • Bone morphogenetic protein 2 is shown to stimulate the production of bone. (wikipedia.org)
  • The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge obtained and maintained intervertebral spinal fusion, improved clinical outcomes, and reduced pain after anterior lumbar interbody arthrodesis in patients with degenerative lumbar disc disease. (wikipedia.org)
  • Silk fibroin, as a natural protein polymer, has unique properties for tissue regeneration. (plos.org)
  • From this discovery, that new bone is formed upon applying a demineralized bone extract in a rabbit muscle he concluded that a certain agent within this crude protein mix has to be responsible for such an ectopic bone growth. (igi-global.com)
  • He named this substance Bone Morphogenetic Protein, generally known as BMP. (igi-global.com)
  • platelet-derived growth factor, insulin-like growth factor, transforming growth factor-beta, fibroblast growth factor, and bone morphogenetic protein. (ukessays.com)
  • The control of surface properties and porosity of calcium phosphate affects cell/protein adhesion and growth and regulates bone mineral formation. (biomedcentral.com)
  • The use of Bone Morphogenetic Protein - 2 is a common means to enhance effectiveness and accelerate the healing process. (biomedcentral.com)
  • The aim of this paper is to review the literature about bone morphogenetic protein type 2 (BMP-2) and on the effect in the alveolar bone augmentation. (bvsalud.org)
  • The aim of this study was to conduct a literature review on the use and clinical viability of human bone morphogenetic protein (rhBMP-2) for grafting bone in Dentistry. (bvsalud.org)
  • Recombinant human bone morphogenetic protein-2 (rhBMP-2) is well-known osteoinductive growth factors that can be used along with various carriers. (intechopen.com)
  • An emerging area of excellence for Dentistry, with outstanding new recruits investigating nanometre-scale bone cements / biomaterials, synthetic tissue-engineered scaffoldings and controlled-release systems for bone reconstruction and salivary gland regeneration, and bioactivation of implants by surface nanostructuring and protein nanopatterning. (mcgill.ca)
  • Primitively established in 1965 by the discovery of bone morphogenetic protein, the field of growth factor technology made stellar advances for many years despite a total lack of clinical applications. (perfusion.com)
  • One of the following was grafted to the maxillary sinus of each rabbit: particulated autogenous bone, demineralized bone matrix (DBM), DBM combined with purified bone morphogenetic protein (BMP-DBM bioimplants) and bioimplants consisting of a poloxamer gel with BMP in 1 of 2 different doses. (jcda.ca)
  • 5 - 7 The microcracks caused by penetration of the Osteotensor (Victory, Nice, France) induce the release of bone matrix growth factors (bone morphogenetic protein and insulin-like growth factor I, II, and beta) 8 that have a range of biologic properties. (allenpress.com)
  • This procedure is indicated when there is no sufficient bone for implantation, or in the case of optimal implant installation for esthetic or functional needs. (ac.ir)
  • GBR can be performed before implant placement, when there is not enough bone for initial stability of implants and less predictable outcomes (staged approach), or performed simultaneously with implantation (combined approach). (ac.ir)
  • Buser D. Twenty years of guided bone regeneration in implant dentistry. (ac.ir)
  • Albrektsson T, Branemark˚ P-I, Hansson H-A, Lindstrom¨ J. Re- quirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. (amazoniabr.org)
  • Carlsson L V, Rostlund¨ T, Albrektsson B, Albrektsson T. Cylindrical implant-bone interface studied in rabbits. (amazoniabr.org)
  • This retrospective case series reports on the use of a new allograft bone product composed of a 70:30 ratio of mineralized to demineralized cortical bone particles to preserve the alveolar ridge dimensions of patients requiring tooth extraction with plans for future dental implant placement. (cdeworld.com)
  • Achieving optimal esthetics, function, and phonetics with implant-supported restorations depends largely on the presence of adequate bone at the dental implant placement site. (cdeworld.com)
  • What was most interesting about the discovery was that her bone had begun to fuse to her implant, which is an indication that the implant was placed while she was still alive. (paaoralsurg.com)
  • Recently the clinical trials and outcomes of DDM/rhBMP-2 have also proved this composite to be safe and efficient in terms of enhanced bone formation, remodeling capacity and reduced concentration of rhBMP-2 in implant dentistry in Korea. (intechopen.com)
  • the most widely accepted and successful is the osseointegrated implant, based on the discovery by Swedish Professor Per-Ingvar Brånemark that titanium can be successfully fused into bone when osteoblasts grow on and into the rough surface of the implanted titanium. (bionity.com)
  • This forms a structural and functional connection between the living bone and the implant. (bionity.com)
  • In 1965 Brånemark, who was by then the Professor of Anatomy at Gothenburg University in Sweden, placed the first titanium dental implant into a human volunteer who was a Swede named Gösta Larrson. (bionity.com)
  • The most common treatment plan calls for several surgeries over a period of months, especially if bone augmentation (bone grafting) is needed to support implant placements. (bionity.com)
  • The authors explain PRP's biologic mechanism of action, the in-office procedure for developing PRP, and most importantly, its application and expected benefits in procedures such as implant placement, periodontal bone and soft tissue surgery, sinus lifts, jaw reconstructions, soft tissue facial augmentations, and facial cosmetic surgeries. (perfusion.com)
  • Clinicians should take into account the role of smoking in treatment outcomes and be aware of the increased risk of implant failure and marginal bone loss particularly if grafting is planned. (regeneration-expert.com)
  • They should also understand the importance of a baseline reference of the bone levels after implant rehabilitation against which to monitor the marginal bone loss over time. (regeneration-expert.com)
  • Using a novel flapless procedure, a series of microcracks are created in the bone by a purpose-designed bone matrix Osteotensor 45 to 90 days before implant surgery. (allenpress.com)
  • Growth factors (GFs) have long been believed to have the potential to accelerate the healing process and, therefore, enhance tissue regeneration in challenging clinical scenarios. (ukessays.com)
  • Bone regeneration has been extensively investigated in the clinical field using biomaterials. (biomedcentral.com)
  • Clinical and histochemical alterations of the periodontal ligament in gerbils after malocclusion induced/Alteraciones clinicas e histoquimicas del ligamento periodontal en gerbiles despues de maloclusion inducida. (thefreelibrary.com)
  • We then utilized CS-Platelet in a variety of dental and craniofacial clinical cases, where regeneration of bone was needed. (biomedcentral.com)
  • In all human clinical cases where CS-Platelet was used, a complete bone repair was achieved. (biomedcentral.com)
  • With the present work we introduce CS-Platelet, a novel and simple biomaterial able to induce regeneration of bone in a variety of clinical situations. (biomedcentral.com)
  • The problems of high energy traumatic injuries of skeleton bones and the methods of their reconstruction in correlation with reparative osteogenesis are relevant for actual clinical and experimental traumatology and orthopedics. (exp-oncology.com.ua)
  • Since the first report of clinical application of DDM (AutoBT® Korea Tooth Bank, Seoul, Korea) that were developed by Korea Tooth Bank in 2010, many experimental and clinical studies have been subjected to improve the biocompatibility, bone forming capacity and to expand clinical applications. (intechopen.com)
  • The soluble osteogenic molecular signals of the transforming growth factor-β (TGF-β) supergene family are the molecular bases of the induction of bone formation and postnatal bone tissue morphogenesis with translation into clinical contexts. (frontiersin.org)
  • Moreover, human clinical trials have been conducted to test whether bone union can be accelerated by local injection of recombinant human (rh)FGF at the fracture site [ 5 ]. (biomedcentral.com)
  • Among the cells in the bone, MSCs have the ability to differentiate into multiple lineages and are relatively easy to obtain although it is necessary to culture the primary cells to obtain sufficient numbers for clinical applications. (biomedcentral.com)
  • Its use in skin regeneration has been documented in over 300 clinical studies over the past several years, many of which are cited in the following website: http://www.ncbi.nlm.nih.gov/pubmed/?term=Integra+substitute+skin. (mit.edu)
  • The release of calcium and phosphorus ions regulates the activation of osteoblasts and osteoclasts to facilitate bone regeneration. (biomedcentral.com)
  • Bone regeneration is intertwined with complex physiological processes by various materials and conditions [ 1 ], and interactions between environment conditions and substrates lead to a balance between osteoclasts and osteoblasts [ 2 ]. (biomedcentral.com)
  • Numerous studies on areas such as the relationship between osteoclasts and osteoblasts, osteogenic differentiation, stimulation effects of bone, cell growth, signaling pathways, and bone growth factors have been conducted in vitro and in vivo [ 2 , 3 , 4 ]. (biomedcentral.com)
  • Injury sites can be sequentially imaged revealing that OSPCs relocate to the injury, increase in number and differentiate into bone forming osteoblasts. (jove.com)
  • MSCs have the capacity to differentiate into osteoblasts and therefore have become one of the most promising cell sources in bone regenerative medicine. (biomedcentral.com)
  • Among the many biomaterials, calcium phosphates which exist in the natural bone have been conducted a number of studies because of its bone regenerative property. (biomedcentral.com)
  • In this review, we will summarize bone regenerative strategies using calcium phosphate by examining the bioactive properties and bone regenerative applications of calcium phosphate. (biomedcentral.com)
  • The discovery of CS-Platelet may represent a cost-effective breakthrough in bone regenerative therapy and an alternative or an adjuvant to the current treatments. (biomedcentral.com)
  • The present study represents a novel endeavor towards the development of innovative approaches in bone regenerative therapy. (biomedcentral.com)
  • Temporary and economic costs for treating patients with alterations of reparative regeneration processes, especially in the high-energy mechanism of trauma, the complexity of their social adaptation, justify the need to search for innovative organ-saving technologies of regenerative medicine for bone integrity restoration. (exp-oncology.com.ua)
  • The newest alternative to the conventional methods of bone plastic surgery is bone restoration methods based on the approaches of regenerative medicine. (exp-oncology.com.ua)
  • Our study was intended to analyze the bone regenerative effects of rhBMP-2 quantitatively based on cone-beam computed tomographic (CBCT) images of patients treated with and without rhBMP-2. (springeropen.com)
  • Planarians are renowned for their regenerative capacity and are an attractive model for the study of adult stem cells and tissue regeneration. (saladgaffe.gq)
  • Bone turns over continuously and is highly regenerative following injury. (jove.com)
  • no sites required any additional bone augmentation. (cdeworld.com)
  • Bone was harvested from the posterior iliac crest of 40 adult New Zealand white rabbits to allow bilateral augmentation of the floor of the maxillary sinus with autogenous bone or other materials. (jcda.ca)
  • Alveolar ridge preservation should therefore be considered for all extraction sites to minimize the extent of bone loss and also reduce the need for extensive grafting and augmentation at a later stage. (regeneration-expert.com)
  • Most bone in the adult is described as lamellar bone since the collagen fibres assume an ordered arrangement in thin sheets. (unu.edu)
  • Where bone is formed very rapidly, such as occurs pre-natally, in the rapidly growing child, or during fracture repair, the collagen fibrils often assume a very irregular orientation. (unu.edu)
  • Site-specific patterns persist in cultured adult bone-derived cells both phenotypically (proliferation rate, response to estrogen and cell volumes), and at the level of specific gene expression (collagen triple helix repeat containing 1, reelin and ras-like and estrogen-regulated growth inhibitor). (jove.com)
  • A sterile surgical collagen product which has a felt or fleece-like structure and which exerts a haemostatic action, has a high absorption capacity for body fluids, promotes the regeneration of tissues, is highly resorptive, has substantially no antigenic activity and has optimum mechanical properties. (google.com.au)
  • A sterile surgical collagen product which has a felt or fleece-like structure and which exerts a haemostatic action, has a high absorption capacity for body fluids, promotes the regeneration of tissues, is highly resorptive, has substantially no antigenic activity and has optimum mechanical properties so as to make it suitable for being applied to or introduced into wounds or into bone cavities. (google.com.au)
  • A further object of the invention is to provide a surgical collagen product having a high haemostatic activity, a high absorption capacity for body fluids, the property of promoting the regeneration of tissues, especially of bone tissues, a high resorbability, as low an antigenic activity as possible and optimum mechanical properties to make it suitable for the application to or the introduction into wounds or into bone cavities. (google.com.au)
  • Many experiments have been performed using biomaterials in vivo and in vitro to promote and understand bone regeneration. (biomedcentral.com)
  • It can be directly contributed to bone regeneration process or assist in the use of other biomaterials. (biomedcentral.com)
  • Human osteoblast-like cells were cultured on two different biomaterials: a human demineralised bone matrix (DBX® Mix, Musculoskeletal Transplant Foundation, NJ, USA, distributed by symthes) and a non-sintered, nanocrystalline, phase-pure hydroxylapatite (Ostim® Paste, Heraeus Kulzer, Hanau, Germany). (quintessenz.de)
  • Osteoclasts have been identified, primarily by morphological criteria, as large, multi-nucleated cells which contact calcified bone matrix and exhibit ruffled borders surrounded by clear zones (Gothlin & Ericsson, 1976). (thefreelibrary.com)
  • Osteogenic Potential of Calcium Hydroxide and Other Materials in Soft Tissue and Bone Wounds," J. Dent. (patents.com)
  • This paper first reviewed the preparation methods of magnetic responsive materials such as magnetic nanoparticles, magnetic polymers, magnetic bioceramic materials and magnetic alloys in recent years, and then introduced its main applications in the field of bone tissue engineering, including promoting osteogenic differentiation, targets release, bioimaging, cell patterning, etc. (eurekaselect.com)
  • BMP-2 is known as osteogenic BMP which is based on its strong bone-inducing activity [ 8 ] and essential for endochondral bone formation [ 9 ]. (alliedacademies.org)
  • Here, in vivo imaging techniques to investigate the role of endogenous osteogenic stem/progenitor cells (OSPCs) and their progeny in bone repair are provided. (jove.com)
  • Periodontitis is a widely prevalent inflammatory disease of the tissues supporting the teeth, characterized by a progressive loss of bone and attachment. (ukessays.com)
  • The ultimate goal of periodontal therapy is the regeneration of periodontal tissues, which consists in stimulating new cementum formation, new alveolar bone apposition, and a functionally-oriented periodontal ligament reconstruction. (ukessays.com)
  • Pidhorz L E, Urban R M, Jacobs J J, Sumner D R, Galante J O. A quantitative study of bone and soft tissues in cementless porous-coated acetabular components retrieved at autopsy. (amazoniabr.org)
  • Even though the cachectic condition severely affects skeletal muscle, a tissue that accounts for ~40% of total body weight, it represents a multi-organ syndrome that involves tissues and organs such as white adipose tissue, brown adipose tissue, bone, brain, liver, gut and heart. (nature.com)
  • After the scientific evidence of osseointegration in the ending of the 1970s, which made viable Implantology, increased the interest of researchers in search by new natural or synthetic substances that could replace tissues bone lost 9 . (bvsalud.org)
  • A surprisingly large number of cytokines have been shown to affect skeletal tissues, at least experimentally, making this a complex topic, but one which is furthering knowledge of how the cellular events of bone growth may be so precisely regulated. (unu.edu)
  • The complexity of the arrangement of the muscle and connective tissues of these appendages make them of great interest for research on regeneration. (frontiersin.org)
  • Magnetic bioinspired micro/nanostructured composite scaffold for bone regeneration. (eurekaselect.com)
  • Moreover, silk materials exhibit excellent strength and toughness to meet the requirements for scaffolds for bone tissue engineering [15] . (plos.org)
  • Biomimetic synthesis of Mg-substituted hydroxyapatite nanocomposites and three-dimensional printing of composite scaffolds for bone regeneration. (annals.org)
  • 5. Deville, S., E. Saiz, and A.P. Tomsia, Freeze casting of hydroxyapatite scaffolds for bone tissue engineering. (ncl.edu.tw)
  • Therefore, the survival time and fate of the seeded cells in vivo plays an important role in influencing the effectiveness of tissue regeneration. (plos.org)
  • This review focuses on five growth factor families that have potential for inducing periodontal regeneration based on their ability to stimulate osteoblast and periodontal ligament cells in vivo and vitro. (ukessays.com)
  • G. Cidonio, M. Glinka, Y.-H. Kim, J. Kanczler, S. Lanham, T. Ahlfeld, A. Lode, J. Dawson, M. Gelinsky, R. Oreffo: Nanoclay-based 3D printed scaffolds promote vascular ingrowth ex vivo and generate bone mineral tissue in vitro and in vivo. (tu-dresden.de)
  • Given that leukemia does not propagate just anywhere in the body and is difficult to grow ex vivo , it was thought that leukemia cells depend on the bone marrow microenvironment (BMM). (haematologica.org)
  • Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. (nature.com)
  • 18 To date, BMP-2, BMP-4 and BMP-7 have all been shown to stimulate de novo, in vitro and in vivo bone formation in various animal models. (jcda.ca)
  • The extruded bones were a segment with a length of 5.5 cm and a cortical bone with a length of 4 cm. (thieme-connect.com)
  • The results of this case series suggest that blended bone allograft containing a 70:30 ratio of mineralized to demineralized cortical bone particles can be successfully used to facilitate future placement of dental implants with as little as 14 weeks of healing. (cdeworld.com)
  • The aim of this case series is to document the use of a relatively new bone allograft product comprised of blended mineralized and demineralized cortical bone for extraction site preservation procedures. (cdeworld.com)
  • Cortical, or compact bone, makes up around 80% of total bone mass, and is most abundant in the shafts of long bones. (unu.edu)
  • Microscopically, cortical bone tissue is made up of a number of cylindrical units, the osteons, at the centre of which is a Haversian canal containing blood vessels and nerves. (unu.edu)
  • In cortical bone, osteons have a well defined longitudinal arrangement. (unu.edu)
  • Just as mechanical microtrauma of the periosteum induces subsequent repair, 4 surgical trauma of the cortical bone results in a burst of localized hard tissue remodeling. (allenpress.com)
  • Calcium phosphate has been utilized to improve bone regeneration in ways such as increasing osteoconductivity for bone ingrowth, enhancing osteoinductivity for bone mineralization with ion release control, and encapsulating drugs or growth factors. (biomedcentral.com)
  • Data are from the 'Porous silk scaffolds for delivery of growth factors and stem cells to enhance bone regeneration' study whose authors may be contacted at [email protected] . (plos.org)
  • The long-term survival of seeded cells after transplantation along with biomaterial scaffolds is a prerequisite for the cells to promote tissue regeneration by directly participating in the process or by secreting key growth factors. (plos.org)
  • Demineralized dentin matrix (DDM) that has osteoinductive and osteoconductive capacities was developed as potential candidate for rhBMP-2 carrier that has its endogenous growth factors and fulfils the requirements such as controlled release kinetics, biocompatibility, biodegradabilities and bone forming capacity. (intechopen.com)
  • GFs are natural biological mediators that regulate key cellular events that are part of the process of tissue repair and regeneration. (ukessays.com)
  • Bone regeneration involves various complex biological processes. (biomedcentral.com)
  • Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. (bvsalud.org)
  • LaBarge, M. A. & Blau, H. M. Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury. (nature.com)
  • During that time, he moved ARI's research emphasis toward the mechanobiology of tissue repair, with a focus on the interaction of mechanical and biological influences on bone formation, remodeling, and healing. (aofoundation.org)
  • The mammalian TGF-β 3 isoform, a pleiotropic member of the family, controls a vast array of biological processes including the induction of bone formation. (frontiersin.org)
  • The cascade of biological responses includes recruitment of stem cells, both locally and at a distance, that participate in bone remodeling. (allenpress.com)
  • A 6-year-old boy presented with a Gustilo type IIIB open fracture on his left leg with a segment of bone loss in his tibia. (thieme-connect.com)
  • Under his leadership, important strides were made in internal fracture fixation, including the development of plates with limited and no contact with the underlying bone avoiding contact necrosis and tissue-friendly surgical procedures. (aofoundation.org)
  • Break a leg, and the fracture will usually mend if the bone is set correctly. (skally.net)
  • The incidence of limb bone fracture and subsequent morbidity and mortality due to excessive bone loss is increasing in the progressively ageing populations of both men and women. (jove.com)
  • A tribute to him and his research was written in the Journal of Bone and Joint Surgery ( Reddi, 2003 ). (wikidot.com)
  • Periodontitis and all periodontal diseases are bacterial infections that destroy the attachment fibers and supporting bone. (ukessays.com)
  • RESUMEN: El objetivo de este articulo es mostrar las alteraciones clinicas e histoquimicas del primer ligamento periodontal del lado derecho, despues de la extraccion del molar superior izquierdo en gerbiles (Meriones unguiculatus). (thefreelibrary.com)
  • Los resultados mostraron que la reaccion de TRAP es capaz de evidenciar la actividad osteoclastica en la hiperfuncion de la semimandibula derecha, explicando los cambios funcionales del ligamento periodontal despues de la extraccion dental, siendo observada una pequena recesion gingival y exposicion radicular de los dientes sin funcion, en los molares inferiores izquierdos. (thefreelibrary.com)
  • For groups in which the poloxamer gel was used as a carrier for BMP or where BMP was used in combination with DBM, the amount of bone generated by 8 weeks was similar to that produced by autogenous bone. (jcda.ca)
  • These bioimplants had more rapid initial bone production than all other materials, including autogenous bone. (jcda.ca)
  • In addition, autogenous bone grafting is associated with a certain degree of morbidity at the harvesting site, including infection and pain, which may increase the length of the hospital stay. (jcda.ca)
  • Stimulation of partial limb regeneration in rats. (wikipedia.org)
  • Electrical stimulation of partial limb regeneration in mammals. (wikipedia.org)
  • An individual's skeletal growth rate and adult limb bone length have an important genetic determinant, but are influenced by many factors including circulating hormones, nutritional intake, mechanical influences and disease. (unu.edu)
  • In contrast to bone loss in the weight-bearing limb, bone mass in the protective skull vault is maintained. (jove.com)
  • Limb bones contain greater amounts of polysulphated glycosaminoglycan stained with Alcian Blue and have significantly higher osteocyte densities than skull bone. (jove.com)
  • Limb: Hox, Shox2, and Tbx genes) in both adult bones and isolated adult bone-derived cells. (jove.com)
  • Together, these site-specific differences support the view that, analogous to different muscle types (cardiac, smooth and skeletal), skull and limb bones represent separate classes of bone. (jove.com)
  • In the 1960s Becker's research also showed that living bone can piezoelectrically generate electric potentials, which led to work on using electricity in the treatment of ununited fractures. (wikipedia.org)
  • Zenkevich G.D., Glycoproteins in the blood serum during the process of bone tissue regeneration after fractures and transplantation, Voprosy meditsinskoi khimii, 1961, vol: 7(6), 592-598. (msk.ru)
  • If the healing of bone fractures is delayed, osteoinductive materials that induce mesenchymal stem cells (MSCs) to form bone are necessary. (biomedcentral.com)
  • Coetzee, Andries S., "Regeneration of Bone in the Presence of Calcium Sulfate," Arch Otolaryngol. (patents.com)
  • The Mayan civilization has been shown to have used the earliest known examples of endosseous implants (implants embedded into bone ), dating back over 1,350 years before Per Brånemark started working with titanium. (bionity.com)
  • Per Brånemark observed that bone had grown into such close proximity with the titanium that it effectively adhered to the metal. (bionity.com)
  • To fabricate bone equivalent we used devitalized allogeneic bone scaffolds (blocks and chips) seeded with cultured autologous cells: bone marrow-derived multipotent mesenchymal stem/stromal cells in mix with periosteal progenitor cells and endothelial progenitor cells. (exp-oncology.com.ua)
  • Our hypothesis is that m ultiple intravenous infusions of mesenchymal stem cells from the bone marrow of a healthy donor will significantly slow the progression of Parkinson's disease when compared to placebo over a year. (michaeljfox.org)
  • By ending the destructive inflammatory process, mesenchymal stem cells may re-establish an equilibrium that promotes cell regeneration. (michaeljfox.org)
  • Calcium phosphate has been widely used in bone regeneration applications because it shows osteoconductive and in some cases osteoinductive features. (biomedcentral.com)
  • All of his work eventually led to the successful placement of dental implants in 1965. (paaoralsurg.com)
  • The success of rehabilitation with dental implants is directly related to the amount of bone tissue of the patient. (bvsalud.org)
  • In addition to the existence of osteoregulation processes based on mechano-transduction, 9 , 10 osteotension triggers and regulates bone regeneration. (allenpress.com)
  • In bone repair, the plaster is mixed with a non-bioresorbable calcium source, such as calcium phosphate ceramic, to stimulate bone formation. (patents.com)
  • Within the magnetic field, the magnetic response material can achieve the targeted release of the drug, improve the performance of the scaffold, and further have a positive impact on bone formation. (eurekaselect.com)
  • The heterotopic bioassay showed formation of bone within the muscular tissue at the site of the implantation of CS-Platelet. (biomedcentral.com)
  • New bone formation was assessed by the radiographic examination. (exp-oncology.com.ua)
  • Pathomorphological analysis of bone equivalent specimens 3-6 months post-op revealed the active remodeling processes and immature bone tissue formation. (exp-oncology.com.ua)
  • The concept that vascular structures support HSPC has long been proposed and is in keeping with the growing idea that definitive hematopoiesis and establishment of a HSPC pool exists well before bone or bone marrow formation. (haematologica.org)
  • He noted compact bone formation around two of the implants which led him to conclude that the implants were placed during life. (bionity.com)
  • Modelling continues throughout adult life with bone resorption equally balanced by bone formation in a healthy skeleton, although in the adult the process is referred to as remodelling. (unu.edu)
  • Histomorphometry was used to demonstrate and quantify bone formation. (jcda.ca)
  • Hand-held bioprinting for de novo vascular formation applicable to dental pulp regeneration. (ukaachen.de)
  • Recombinant hTGF-β 3 induces substantial bone formation when implanted with either collagenous bone matrices or coral-derived macroporous bioreactors in the rectus abdominis muscle of the non-human primate Papio ursinus . (frontiersin.org)
  • In marked contrast, the three mammalian TGF-βs do not initiate the induction of bone formation in rodents and lagomorphs. (frontiersin.org)
  • Coral-derived macroporous constructs preloaded with binary applications of hTGF-β 3 and hNoggin also show down-regulation of BMP-2 with the induction of limited bone formation. (frontiersin.org)
  • Radiographic and histological evaluation showed that bone union had been achieved at 12 weeks in group C, while group B showed callus formation and bridging callus but non-union, and in group A, callus formation alone was evident. (biomedcentral.com)
  • Furthermore, MSCs have the possibility to transmit or release various conductive factors to induce new vessel and bone formation [ 7 - 9 ]. (biomedcentral.com)
  • Fluid pressure causes bone resorption in a rabbit model of prosthetic loosening cheap maxalt 10 mg with mastercard. (amazoniabr.org)
  • 6,7 Horizontal bone resorption of up to 30% lingually and 56% buccally has been reported, 8 with overall reduction in ridge width of up to 50% found 1 year after extraction. (cdeworld.com)
  • Stem cell-based tissue engineering shows promise for bone regeneration and requires artificial microenvironments to enhance the survival, proliferation and differentiation of the seeded cells. (plos.org)
  • The issue over reports of unexpected plasticity in adult stem cell differentiation remains a focus of debate, and evidence for bone marrow-derived stem cell contributions to renal repair has been challenged. (aspetjournals.org)
  • Boning up on stem cell Igf2-P2 function The insulin-like growth factor (IGF)/insulin signalling pathway regulates cell proliferation, differentiation, aging and life span. (biologists.com)
  • The scaffold microenvironment for stem cell based bone tissue engineering. (eurekaselect.com)
  • Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. (nature.com)
  • Stem cell biology and cellular regeneration. (miami.edu)
  • These methods offer a means of investigating the role of stem cell-intrinsic and extrinsic molecular regulators for bone regeneration and repair. (jove.com)
  • [6] Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
  • Early studies by Hari Reddi unraveled the sequence of events involved in bone matrix-induced bone morphogenesis ( Reddi, 1972 ). (wikidot.com)
  • The induction of bone by hTGF-β 3 /preloaded bioreactors is orchestrated by inducing fibrin-fibronectin rings that structurally organize tissue patterning and morphogenesis within the macroporous spaces. (frontiersin.org)
  • In addition, for bone tissue engineering scaffolds, essential characteristics, such as a highly porous structure, mechanical properties, biocompatibility, slow degradation and suitable surface chemistry are key [13] . (plos.org)
  • Development of a solvent-free polylactide/calcium carbonate composite for selective laser sintering of bone tissue engineering scaffolds. (ukaachen.de)
  • Lundgren AK, Sennerby L, Lundgren D. Guided jaw-bone regeneration using an experimental rabbit model. (ac.ir)
  • In 1952 the Swedish orthopaedic surgeon , P I Brånemark, was interested in studying bone healing and regeneration, and adopted the Cambridge designed 'rabbit ear chamber' for use in the rabbit femur. (bionity.com)
  • Plaster: A Bone Substitute in the Mandible of Dogs," J. Dent, Res. (patents.com)
  • to facilitate guided bone regeneration in the rat mandible. (ac.ir)
  • The mandible was found with bits of seashell and bone in it where a tooth once was. (paaoralsurg.com)
  • Marginal bone loss is worse in smokers than in non-smokers, with the loss being worse in the maxilla than the mandible. (regeneration-expert.com)
  • Plaster of Paris is employed to form implants as well as a bioresorbable scaffold for implants and bone repair in animals. (patents.com)
  • Alternative methods such as allografts, xenografts, and synthetic materials [ 2 ] were thus developed to repair bone. (biomedcentral.com)
  • From the time of Hippocrates it has been known that bone has considerable potential for regeneration and repair. (wikidot.com)
  • Cell and Molecular Strategies for Massive Bone Repair/Regeneration. (patentgenius.com)
  • But it cannot repair itself, because it lacks the stem cells that would allow for neuronal regeneration. (skally.net)
  • Using osteo-lineage cell tracing models and intravital imaging of induced microfractures in calvarial bone, OSPCs can be directly observed during the first few days after injury, in which critical events in the early repair process occur. (jove.com)