Haemophilus influenzae: A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.Haemophilus influenzae type b: A type of H. influenzae isolated most frequently from biotype I. Prior to vaccine availability, it was a leading cause of childhood meningitis.Haemophilus Infections: Infections with bacteria of the genus HAEMOPHILUS.Haemophilus Vaccines: Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.Meningitis, Haemophilus: Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.Vaccines, Conjugate: Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.Bacterial Capsules: An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.Polysaccharides, Bacterial: Polysaccharides found in bacteria and in capsules thereof.Haemophilus: A genus of PASTEURELLACEAE that consists of several species occurring in animals and humans. Its organisms are described as gram-negative, facultatively anaerobic, coccobacillus or rod-shaped, and nonmotile.Vaccines, Combined: Two or more vaccines in a single dosage form.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Diphtheria-Tetanus-Pertussis Vaccine: A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.Epiglottitis: Inflammation of the epiglottis.Diphtheria Toxoid: The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.Tetanus ToxoidImmunization Schedule: Schedule giving optimum times usually for primary and/or secondary immunization.Poliovirus Vaccine, Inactivated: A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.Bacterial Outer Membrane Proteins: Proteins isolated from the outer membrane of Gram-negative bacteria.Counterimmunoelectrophoresis: Immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.Diphtheria-Tetanus-acellular Pertussis Vaccines: Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Bacterial Vaccines: Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.Meningitis, Bacterial: Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.Hepatitis B Vaccines: Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Immunization, Secondary: Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.Nasopharynx: The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.Haemophilus ducreyi: A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.Oropharynx: The middle portion of the pharynx that lies posterior to the mouth, inferior to the SOFT PALATE, and superior to the base of the tongue and EPIGLOTTIS. It has a digestive function as food passes from the mouth into the oropharynx before entering ESOPHAGUS.Neisseria meningitidis: A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype.Latex Fixation Tests: Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)Blood Bactericidal Activity: The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.Carrier State: The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.Transferrin-Binding Proteins: A class of carrier proteins that bind to TRANSFERRIN. Many strains of pathogenic bacteria utilize transferrin-binding proteins to acquire their supply of iron from serum.PentosephosphatesPolysaccharidesEpiglottis: A thin leaf-shaped cartilage that is covered with LARYNGEAL MUCOSA and situated posterior to the root of the tongue and HYOID BONE. During swallowing, the epiglottis folds back over the larynx inlet thus prevents foods from entering the airway.Pharynx: A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx).Fimbriae, Bacterial: Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Meningitis, Meningococcal: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.AlaskaOtitis Media: Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.Meningococcal Vaccines: Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.Immunization Programs: Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Neisseria meningitidis, Serogroup C: Strains of Neisseria meningitidis responsible for most sporadic cases in teenagers and almost all outbreaks of disease in this age group. These strains are less common in infants.Genes, Bacterial: The functional hereditary units of BACTERIA.Bacterial Proteins: Proteins found in any species of bacterium.Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Tetanus: A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.Pertussis Vaccine: A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Chinchilla: A genus of the family Chinchillidae which consists of three species: C. brevicaudata, C. lanigera, and C. villidera. They are used extensively in biomedical research.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Infant, Newborn: An infant during the first month after birth.Moraxella (Branhamella) catarrhalis: Gram-negative aerobic cocci of low virulence that colonize the nasopharynx and occasionally cause MENINGITIS; BACTEREMIA; EMPYEMA; PERICARDITIS; and PNEUMONIA.Pneumococcal Vaccines: Vaccines or candidate vaccines used to prevent infections with STREPTOCOCCUS PNEUMONIAE.Chloramphenicol: An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)Ampicillin Resistance: Nonsusceptibility of a microbe to the action of ampicillin, a penicillin derivative that interferes with cell wall synthesis.Penicillin Resistance: Nonsusceptibility of an organism to the action of penicillins.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Agglutination Tests: Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Panophthalmitis: Acute suppurative inflammation of the inner eye with necrosis of the sclera (and sometimes the cornea) and extension of the inflammation into the orbit. Pain may be severe and the globe may rupture. In endophthalmitis the globe does not rupture.Child Day Care Centers: Facilities which provide care for pre-school and school-age children.Transformation, Bacterial: The heritable modification of the properties of a competent bacterium by naked DNA from another source. The uptake of naked DNA is a naturally occuring phenomenon in some bacteria. It is often used as a GENE TRANSFER TECHNIQUE.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Diphtheria: A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.Cefotaxime: Semisynthetic broad-spectrum cephalosporin.Clostridium tetani: The cause of TETANUS in humans and domestic animals. It is a common inhabitant of human and horse intestines as well as soil. Two components make up its potent exotoxin activity, a neurotoxin and a hemolytic toxin.Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.Pneumococcal Infections: Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.HemopexinVaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Porins: Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Diphtheria Toxin: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.Haemophilus parasuis: A species of gram-negative bacteria in the genus HAEMOPHILUS found, in the normal upper respiratory tract of SWINE.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Immunoglobulin Isotypes: The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.Immunoglobulin Allotypes: Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.Gambia: A republic in western Africa, constituting an enclave within SENEGAL extending on both sides of the Gambia River. Its capital is Banjul, formerly Bathurst.Haemophilus parainfluenzae: A species of gram-negative bacteria in the genus HAEMOPHILUS, ubiquitous in the human ORAL CAVITY and PHARYNX. It has low pathogenicity but is occasionally implicated in ENDOCARDITIS in humans.Population Surveillance: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Dose-Response Relationship, Immunologic: A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.Drug and Narcotic Control: Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.Ceftriaxone: A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.Poliovirus Vaccines: Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).Immunization, Passive: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Hemagglutination: The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).Indians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.Pneumonia, Pneumococcal: A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.Epitopes: Sites on an antigen that interact with specific antibodies.Iron-Binding Proteins: Proteins that specifically bind to IRON.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Molecular Weight: The sum of the weight of all the atoms in a molecule.Opsonin Proteins: Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.Mumps Vaccine: Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Immunity, Maternally-Acquired: Resistance to a disease-causing agent induced by the introduction of maternal immunity into the fetus by transplacental transfer or into the neonate through colostrum and milk.Adhesiveness: A property of the surface of an object that makes it stick to another surface.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Virulence: The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Purpura: Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).Vaccines, Acellular: Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.Measles-Mumps-Rubella Vaccine: A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.Splenectomy: Surgical procedure involving either partial or entire removal of the spleen.Complement System Proteins: Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).Fimbriae Proteins: Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).Bacterial Infections: Infections by bacteria, general or unspecified.Immunosorbent Techniques: Techniques for removal by adsorption and subsequent elution of a specific antibody or antigen using an immunosorbent containing the homologous antigen or antibody.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Amoxicillin-Potassium Clavulanate Combination: A fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate.Mouth Mucosa: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.Chancroid: Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Whooping Cough: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.Serum Bactericidal Test: Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Pneumonia: Infection of the lung often accompanied by inflammation.Rubella Vaccine: A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)Electrophoresis, Gel, Pulsed-Field: Gel electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Blotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.Haemophilus somnus: A species of gram-negative bacteria (currently incertae sedis) causing multisystem disease in CATTLE.Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Ear, Middle: The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Developing Countries: Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.United StatesMoraxellaceae Infections: Infections with bacteria of the family MORAXELLACEAE.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Blood: The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Immunoglobulin Variable Region: That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.Animals, Newborn: Refers to animals in the period of time just after birth.Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Great BritainOtitis Media with Effusion: Inflammation of the middle ear with a clear pale yellow-colored transudate.FinlandBacteriological Techniques: Techniques used in studying bacteria.Restriction Mapping: Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.Immunoglobulin kappa-Chains: One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Drug Incompatibility: The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)Mass Vaccination: Administration of a vaccine to large populations in order to elicit IMMUNITY.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Transformation, Genetic: Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.Penicillinase: A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-.Neisseria meningitidis, Serogroup A: Strains of Neisseria meningitidis responsible for most outbreaks of meningococcal disease in Western Europe and the United States in the first half of the 20th century. They continue to be a major cause of disease in Asia and Africa, and especially localized epidemics in Sub-Sahara Africa.Chloramphenicol Resistance: Nonsusceptibility of bacteria to the action of CHLORAMPHENICOL, a potent inhibitor of protein synthesis in the 50S ribosomal subunit where amino acids are added to nascent bacterial polypeptides.Nurseries: Facilities which provide care for infants.Adhesins, Bacterial: Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Ketolides: Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.Child, Hospitalized: Child hospitalized for short term care.EnglandErythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
"Haemophilus influenzae". NCBI Taxonomy Browser. 727. Type strain of Haemophilus influenzae at BacDive - the Bacterial Diversity ... "Haemophilus influenzae type B (HiB)". Health Topics A to Z. Retrieved 2011-03-29. Jin Z, Romero-Steiner S, Carlone GM, Robbins ... Effective vaccines for Haemophilus influenzae Type B have been available since the early 1990s, and is recommended for children ... Haemophilus influenzae (formerly called Pfeiffer's bacillus or Bacillus influenzae) is a Gram-negative, coccobacillary, ...
Haemophilus influenzae biogroup aegyptius
"Haemophilus aegyptius bacteremia in Brazilian purpuric fever." Lancet ii (1987): 761-3. Type strain of Haemophilus influenzae ... "Biochemical, Genetic and Epidemiologic Characterization of Haemophilus influenzae Biogroup Aegyptius (Haemophilus aegyptius) ... Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly ... "Deoxyribonucleic acid relatedness between Haemophilus aegyptius and Haemophilus influenza," Elsevier, 137B (1986): 155-163. ...
Medical exclusion of immigrants
Haemophilus influenzae type B, Rotavirus, Varicella, Influenza, Hepatitis A and B, Pertussis, and Polio. These requirements are ... influenza type B and hepatitis B". There were four inspection lines separated by iron railings, which then converge into two ... The ratios were 200,000: 6, 500,000: 8, and 900,000: 16 in 1892, 1902, and 1905, respectively. The inspection at Ellis Island ... "Birn Per Eyelid: The Medical Inspection Of Immigrants At Ellis Island, 1892-1914." Dynamis 17.(1997): 281-316. America: History ...
History of virology
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Centers for Disease Control and Prevention (CDC) (2002). "Progress toward elimination of Haemophilus influenzae type b invasive ... As a more modest example, infections caused by Haemophilus influenzae, a major cause of bacterial meningitis and other serious ... Analysis by the CDC scientists showed that the measles virus type in this outbreak (B3) was identical to the virus type that ... and autoimmune diseases such as type 1 diabetes, as well as hypotheses that vaccinations can transmit bovine spongiform ...
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Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ... Type IV: Proximal gastroesophageal ulcer.. *Type V: Can occur throughout the stomach. Associated with the chronic use of NSAIDs ... Type I: Ulcer along the body of the stomach, most often along the lesser curve at incisura angularis along the locus minoris ... Another type of NSAIDs, called COX-2 selective anti-inflammatory drugs (such as celecoxib), preferentially inhibit COX-2, which ...
Haemophilus:. *H. influenzae *Haemophilus meningitis. *Brazilian purpuric fever. *H. ducreyi *Chancroid. *H. parainfluenzae * ... Cholera is caused by a number of types of Vibrio cholerae, with some types producing more severe disease than others. It is ... susceptibility to cholera is also affected by their blood type, with those with type O blood being the most susceptible. ... This type of toilet stops transmission of disease via the fecal-oral route due to water pollution. ...
Pinkbook | Hib | Epidemiology of Vaccine Preventable Diseases | CDC
Haemophilus influenzae type b Chapter of Pinkbook: (Epidemiology and Prevention of Vaccine-Preventable Diseases) ... Haemophilus influenzae type b (Hib) Routine Vaccination Schedule. Haemophilus influenzae type b (Hib) Routine Vaccination ... Haemophilus influenzae type b Vaccine Schedule for Previously Unvaccinated Children. Haemophilus influenzae type b Vaccine ... Haemophilus influenzae type b Vaccines. A pure polysaccharide vaccine was licensed for use in the United States in 1985 and was ...
Haemophilus influenzae - Wikipedia
"Haemophilus influenzae". NCBI Taxonomy Browser. 727. Type strain of Haemophilus influenzae at BacDive - the Bacterial Diversity ... "Haemophilus influenzae type B (HiB)". Health Topics A to Z. Retrieved 2011-03-29. Jin Z, Romero-Steiner S, Carlone GM, Robbins ... Effective vaccines for Haemophilus influenzae Type B have been available since the early 1990s, and is recommended for children ... Haemophilus influenzae (formerly called Pfeiffers bacillus or Bacillus influenzae) is a Gram-negative, coccobacillary, ...
A review of the role of Haemophilus influenzae in community-acquired pneumonia | Springer for Research & Development
In an era when Haemophilus influenzae type b (Hib) conjugate vaccine is widely used, the incidence of Hib as a cause of ... Haemophilus infuenzae type a; Hib, Haemophilus infuenzae type b; Hic, Haemophilus infuenzae type c; Hid, Haemophilus infuenzae ... Cases of Haemophilus influenzae type e (Hie) and H. influenzae type f (Hif) bacteraemia in England and Wales, 2009-2012, by age ... Haemophilus infuenzae type e; Hif, Haemophilus infuenzae type f; n, number. a32/42 (76%) H. influenzae isolates serotyped. ...
General Recommendations on Immunization
Haemophilus b conjugate vaccines for prevention of Haemophilus influenzae type b disease among infants and children two months ... Haemophilus influenzae type b Vaccine Hib conjugate vaccines are available in single or combined antigen preparations. Hib ... Some vaccines contain highly defined antigens (e.g., the polysaccharide of Haemophilus influenzae type b or the surface antigen ... Scheifele D, Bjornson G, Barreto L, Meekison W, Guasparini R. Controlled trial of Haemophilus influenzae type b diphtheria ...
Moraxella catarrhalis - WikiMili, The Free Encyclopedia
Haemophilus influenzae is a Gram-negative, coccobacillary, facultatively anaerobic pathogenic bacterium belonging to the ... The two main types are acute otitis media (AOM) and otitis media with effusion (OME). AOM is an infection of rapid onset that ... The whole genome sequence of M. catarrhalis CCUG 353 type strain was deposited and published in DNA Data Bank of Japan, ... Type strain of Moraxella catarrhalis at BacDive - the Bacterial Diversity Metadatabase ...
Haemophilus influenzae type b - meddic
Haemophilus influenzae type b. 「Haemophilus influenzae」. [★] ラ. Haemophilus influenzae. 同. インフルエンザ菌. 関. 細菌、髄膜炎、Haemophilus ... Haemophilus influenzae type b vaccine, Hib vaccine. 関. ヘモフィルスワクチン Haemophilus vaccine、インフルエンザ菌 Haemophilus influenzae. Hib, ... Haemophilus influenzae. 同. インフルエンザ菌. 関. 細菌、髄膜炎、Haemophilus influenzae type b. 生物的特徴. *グラム陰性桿菌 ... インフルエンザ菌 Haemophilus influenzae. WordNet. *write by means of a keyboard with types; type the acceptance letter, please (同) ...
Microbiology Society Journals | The return of Pfeiffer's bacillus: Rising incidence of ampicillin resistance in Haemophilus...
The implementation of the Hib vaccine, targeting the major capsule type of H. influenzae, almost eradicated the disease in ... However, a rising number of infections are caused by non-typeable H. influenzae (NTHi), which has no capsule and against which ... influenzae was included in the recently released priority list of antibiotic-resistant bacteria by the WHO. This review ... Haemophilus influenzae, originally named Pfeiffers bacillus after its discoverer Richard Pfeiffer in 1892, was a major risk ...
Science Source - Haemophilus influenzae, SEM
In infants and young children, H. influenzae type b (Hib) causes bacteremia, pneumonia, epiglottitis and acute bacterial ... SS2104014 Haemophilus influenzae (formerly called Pfeiffers bacillus or Bacillus influenzae) is a gram-negative, ... H. influenzae was first described in 1892 by Richard Pfeiffer during an influenza pandemic. The bacterium was mistakenly ... Naturally acquired disease caused by H. influenzae seems to occur in humans only. ...
Before 1990, strains of Haemophilus influenzae type b were found in the upper respiratory tract of 3-5% of children and a small ... reflecting routine immunization of infants against H influenzae type b. Non-type-b encapsulated H influenzae are present in the ... In the mid-1980s, before the introduction of effective vaccines, ~ 10,000-12,000 cases of H influenzae type-b meningitis ... Meningitis is the most common and serious form of invasive H influenzae type-b disease. ...
Introduction - the Spanish Flu pandemic of 1918 - Influenza
... haemophilus influenzae, was to blame, they were in any case in no position to do anything about it, even if they had been ... That variant is called type A subtype H1N1. The meaning of the letter and number designations for flu subtypes will be ... 3:35Skip to 3 minutes and 35 secondsThe candidate suggested at the time was a bacterium that was given the name haemophilus ... the technical classification uses the term type and subtype-- the same general variety as the first flu strains isolated in the ...
Pneumonia | eNetMD
Type B H. influenzae is a well-established pathogen primarily in infants and young children, but is now a relatively rare cause ... Haemophilus influenzae. This organism was originally described in 1892 by Pfeiffer who erroneously thought it was the agent of ... Aetiology-most cases are caused by microbial pathogens, the commonest being Streptococcus pneumoniae, Haemophilus influenzae, ... influenzae in adults is infrequent. Most patients simply have a nonspecific pneumonia, with H. influenzae as the only potential ...
Haemophilus influenzae biogroup aegyptius - Wikipedia
"Haemophilus aegyptius bacteremia in Brazilian purpuric fever." Lancet ii (1987): 761-3. Type strain of Haemophilus influenzae ... "Biochemical, Genetic and Epidemiologic Characterization of Haemophilus influenzae Biogroup Aegyptius (Haemophilus aegyptius) ... Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly ... "Deoxyribonucleic acid relatedness between Haemophilus aegyptius and Haemophilus influenza," Elsevier, 137B (1986): 155-163. ...
Genome: Facts, Discussion Forum, and Encyclopedia Article
Haemophilus influenzae. Haemophilus influenzae. Haemophilus influenzae, formerly called Pfeiffers bacillus or Bacillus ... It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in ... Haemophilus influenzae. Haemophilus influenzae, formerly called Pfeiffers bacillus or Bacillus influenzae, Gram-negative, rod- ... The first bacterial genome to be completed was that of Haemophilus influenzae. ...
Haemophilus influenzae : Wikis (The Full Wiki)
Generic protocol for population-based surveillance of Haemophilus influenzae type B. World Health Organization. 1997. WHO/VRD/ ... Haemophilus influenzae 86-028NP - Haemophilus influenzae PittEE - Haemophilus influenzae PittGG - Haemophilus influenzae Rd ... Genus: Haemophilus. Species: Haemophilus influenzae. Strain: Haemophilus influenzae biotype aegyptius - ... Haemophilus influenzae. (Lehmann & Neumann 1896). Winslow et al. 1917. Haemophilus influenzae, formerly called Pfeiffers ...
Question: Is influenza A virus or bacteria? (2019)
Haemophilus influenzae (formerly called Pfeiffers bacillus or Bacillus influenzae) is a Gram-negative, coccobacillary, ... Infection of the bladder (cystitis). This type of UTI is usually caused by Escherichia coli (E. coli), a type of bacteria ... such as Haemophilus influenzae and Neisseria meningitidis. The agar is named for its color and contains no chocolate products. ... Haemophilus influenzae, and Moraxella catarrhalis). These atypical organisms include special bacteria, viruses, fungi, and ...
NOVEL FORMULATIONS WHICH STABILIZE AND INHIBIT PRECIPITATION OF IMMUNOGENIC COMPOSITIONS - Patent application
0154] Bolgiano et al., "Effect of Physico-Chemical Modification on the Immunogenicity of Haemophilus influenzae Type b ... polysaccharides and Haemophilus influenzae type b (Hib) polysaccharides, conjugated to either a tetanus toxoid (TT) or a CRM197 ... Type 4 200 μg/mL of Fiber-like white particulates Fiber-like white particulates Type 4 Example 4 Aluminum Adjuvants Inhibit the ... Haemophilus influenzae protein D, can also be used. Other proteins, such as ovalbumin, keyhole limpet hemocyanin (KLH), bovine ...
Pneumonia - no child should die from a disease we can prevent - Our World in Data
"Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: ... PCV and Hib vaccines protect children from pneumonia caused by pneumococcus and H. influenzae. Researchers have estimated that ... The principles and practice of medicine. D. Appleton and Company, (1892-1942). ...
Moxifloxacin - DrugBank
Aerobic Gram-negative microorganisms: Acinetobacter lwoffii, Haemophilus influenzae, and Haemophilus parainfluenzae. Other ... Type. Small Molecule. Groups. Approved, Investigational. Description. Moxifloxacin is a synthetic fluoroquinolone antibiotic ... Perez-Vazquez M, Roman F, Aracil B, Canton R, Campos J: Laboratory detection of Haemophilus influenzae with decreased ... Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). Pharmacological action. Yes ...
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... external resources ICD-10 A49.2 ICD-9 041.5 Haemophilus influenzae H. influenzae on a blood agar ... Unencapsulated H. influenzae (non-B type) causes ear (otitis media) and eye (conjunctivitis) infections and sinusitis in ... Haemophilus influenzae. (Lehmann & Neumann 1896). Winslow et al. 1917 Haemophilus influenzae, formerly called Pfeiffers ... H. influenzae was the first free-living organism to have its entire genome sequenced. Haemophilus was chosen because one of the ...
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Haemophilus influenzae was first recognized in 1892 by Pfeiffer, who erroneously concluded that the bacterium was the cause of ... The immune system, composed of a variety of cell types and soluble factors, is geared toward the recognition of and response to ... This study examines how different types of performance measures were weighted in a subjective balanced scorecard bonus plan ... Characterization of animal genetic resources for food and agriculture (AnGR) involves three types of information: phenotypic, ...
Bacteria: Facts, Discussion Forum, and Encyclopedia Article
s, such as Haemophilus influenzae. Haemophilus influenzae. Haemophilus influenzae, formerly called Pfeiffers bacillus or ... Nutritional types in bacterial metabolism. Nutritional type. Source of energy. Source of carbon. Examples. ... In these fruiting bodies, the bacteria perform separate tasks; this type of cooperation is a simple type of multicellular. ... The best known are its neurotoxins, subdivided in types A-G, that cause the flaccid muscular paralysis seen in botulism. It is ...
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Pfeiffer first isolated and described Haemophilus. influenzae as a cause of human influenza (1892). So it is also known as ... It can be subdivided into different antigenic types (e.g. S. agalactiae, S. pneumonae). However capsules of S. equi, S. ... In 1922, Rivers described it as Haemophilus canis. In 1925, Mitchell isolated Haemophilus ovis from the respiratory tract of ... and a small gram negative rod as early as 1910, latter became known as Haemophilus parasuis. It was first isolated by Hjarre ...
Lipopolysaccharide- and Cholera Toxin-Specific Subclass Distribution of B-Cell Responses in Cholera | Clinical and Vaccine...
1986) Functional characterization of human IgG, IgM and IgA antibody directed to the capsule of Haemophilus influenzae type b. ... 1994) Heavy-chain isotype patterns of human antibody-secreting cells induced by Haemophilus influenzae type b conjugate ... I. Simultaneous detection of distinct types of antibody-secreting cells. J. Immunol. Methods 115:31-37. ... Several factors may influence the subclass pattern of the antibody response in infections, important among which are the type ...
A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotyping | BMC...
98 MLVA genotypes were obtained compared to 51 sequences types generated by MLST. The MLVA scheme generated clusters which ... Multilocus sequence typing (MLST) is currently the reference method for genotyping Streptococcus agalactiae strains, the ... is a PCR-based method that was originally developed for the typing of Haemophilus influenzae , Mycobacterium tuberculosis [ ... Outbreak of amoxicillin-resistant Haemophilus influenzae type b: variable number of tandem repeats as novel molecular markers. ...
Hib Immunization: Preventable Diseases
Haemophilus influenzae type b, more often called Hib, is a bacterium that can cause severe infections, particularly in young ... Haemophilus influenzae type b, more often called Hib, is a bacterium that can cause severe and serious infections, particularly ... Technically Speaking: You might hear that Haemophilus influenzae type b vaccine is given to "protect against Hib," but that is ... Hib was first identified in a group of patients during an influenza outbreak in 1892, before scientists discovered that the flu ...
Pfeiffer'sStreptococcusRichard PfeifferStrainsInfectionNTHiMeningitisConjugate vaccineSerotypeGenomePneumoniaDiseasesSputumClassificationAegyptiusDiseaseInfluenza pandemicHuman pathogenVirusesClassified by multilocusNasopharynxCapsularVaccineSpecimenCoccobacilliPittmanGramAntigenVaccinationOrganismInvasive infectionsAgarTetanusVirulenceSusceptibleOccurSerotypesProtein
- Haemophilus influenzae, originally named Pfeiffer's bacillus after its discoverer Richard Pfeiffer in 1892, was a major risk for global health at the beginning of the 20th century, causing childhood pneumonia and invasive disease as well as otitis media and other upper respiratory tract infections. (microbiologyresearch.org)
- X and V. It was isolated in 1892 by Pfeiffer, hence known as Pfeiffer's bacillus . (blogspot.com)
- Most cases are due either to viruses, such as adenovirus or respiratory syncytial virus, or to bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus amd Mycoplasma pneumoniae. (enetmd.com)
- Multilocus sequence typing (MLST) is currently the reference method for genotyping Streptococcus agalactiae strains, the leading cause of infectious disease in newborns and a major cause of disease in immunocompromised children and adults. (biomedcentral.com)
- The majority of cases are associated with an infection with Streptococcus pneumoniae and Neisseria meningitidis, whereas Haemophilus influenzae type b (Hib) infections have been virtually eradicated as a result of routine vaccination policies. (alpfmedical.info)
- Accurate and rapid diagnosis of bacterial arthritis is not always possible in unvaccinated ( Streptococcus pneumoniae and Haemophilus influenzae type B) children in Iran. (jjmicrobiol.com)
- This is against a background of increasing prevalence of antimicrobial resistance, notably the continued spread of beta-lactamase-mediated resistance in Haemophilus influenzae and Moraxella catarrhalis, and penicillin, macrolide and quinolone resistance in Streptococcus pneumoniae. (faintpower.tk)
- In the pre-Hib-vaccine era, type b organisms accounted for 95% of all H. influenzae strains that caused invasive disease. (cdc.gov)
- Non-typeable H. influenzae (NTHi) strains and, occasionally, other encapsulated serotypes of H. influenzae are now the cause of the majority of invasive H. influenzae infectons, including bacteraemic CAP. (springer.com)
- In this review the evidence for the role of NTHi and capsulated strains of H. influenzae will be examined. (springer.com)
- Both capsulated and non-capsulated or non-typeable strains of H. influenzae (NTHi) can cause pneumonia. (springer.com)
- Some strains of H. influenzae are encapsulated whilst others are non-encapsulated. (springer.com)
- NTHi strains cannot be serotyped by conventional type-specific antiserum agglutination. (springer.com)
- In 1930, two major categories of H. influenzae were defined: the unencapsulated strains and the encapsulated strains. (wikipedia.org)
- Unencapsulated H. influenzae strains are unaffected by the Hib vaccine and cause ear infections (otitis media), eye infections (conjunctivitis), and sinusitis in children, and are associated with pneumonia. (wikipedia.org)
- Before 1990, strains of Haemophilus influenzae type b were found in the upper respiratory tract of 3-5% of children and a small percentage of adults. (antiinfectivemeds.com)
- Colonization rates with type-b strains are even lower now, reflecting routine immunization of infants against H influenzae type b. (antiinfectivemeds.com)
- Unencapsulated strains are termed nontypable (NTHi) because they lack capsular serotypes, however they can be classified by multi-locus sequence typing. (thefullwiki.org)
- Most strains of H. influenzae are opportunistic pathogens - that is, they usually live in their host without causing disease, but cause problems only when other factors (such as a viral infection or reduced immune function) create an opportunity. (thefullwiki.org)
- Most infections are caused by H. influenzae strains belonging to capsular serotype b(Hib). (blogspot.com)
- It was not until 1933 that it was established that influenza was caused by a virus and that H. influenzae was a cause of secondary infection. (cdc.gov)
- In some persons, H. influenzae causes an invasive infection. (cdc.gov)
- Hib was one of the most common causes of invasive H. influenzae infection, including bacteraemic pneumonia in young children, whereas NTHi was generally considered to be a major cause of chronic respiratory infections and pneumonia in adults. (springer.com)
- However, H. influenzae isolated from cerebrospinal fluid or blood would indicate H. influenzae infection. (wikipedia.org)
- Pneumonia is usually caused by various types of infection. (enetmd.com)
- There are three types of influenza viruses, identified as A, B, and C. Influenza A can infect a range of animal species, including humans, pigs, horses, and birds, but only humans are infected by types B and C. Influenza A is responsible for most flu cases, while infection with types B and C virus are less common and cause a milder illness. (encyclopedia.com)
- There are two types of neonatal infection. (justia.com)
- There has been a dramatic reduction in invasive Haemophilus influenzae class B diseases since the widespread make use of of the Hib vaccine (Centers as a replacement for Infection Subdue and Fending, 2008b). (e-kuznecova.ru)
- In infants and young children, H. influenzae type b (Hib) causes bacteremia, pneumonia, epiglottitis and acute bacterial meningitis. (wikipedia.org)
- Although subsequent studies revealed the fallacy of this idea, H influenzae has proved to be a common cause of localized respiratory tract and systemic disease, including meningitis, epiglottitis, pneumonia, pyogenic arthritis, cellulitis, otitis media, and sinusitis, among others (Box 1). (antiinfectivemeds.com)
- Meningitis is the most common and serious form of invasive H influenzae type-b disease. (antiinfectivemeds.com)
- If pregnant women are vaccinated with type III capsule so that the infants are passively immunised, the incidence of the late onset meningitis is reduced but is not entirely eliminated. (justia.com)
- In developed countries, disease resulting from Haemophilus influenzae prototype B, positively the most normal agency of meningitis in children, has decreased dramatically since the introduction of the Hib vaccine. (ulickaya.ru)
- The pathogenesis of H. influenzae infections is not completely understood, although the presence of the capsule in encapsulated type b (Hib), a serotype causing conditions such as epiglottitis, is known to be a major factor in virulence. (wikipedia.org)
- Haemophilus influenzae serotype a as a cause of serious invasive infections. (microbiologyresearch.org)
- In this paper the current role of H. influenzae as a causative agent of pneumonia in children and adults will be reviewed. (springer.com)
- There are two main types: lobar pneumonia and bronchopneumonia. (enetmd.com)
- Unencapsulated H. influenzae causes ear infections ( otitis media ), eye infections ( conjunctivitis ), and sinusitis in children and is associated with pneumonia . (thefullwiki.org)
- Unencapsulated H. influenzae (non-B type) causes ear ( otitis media ) and eye ( conjunctivitis ) infections and sinusitis in children, and is associated with pneumonia . (bionity.com)
- Still, H. influenzae is responsible for a wide range of clinical diseases. (thefullwiki.org)
- Diseases due to H. influenzae are of 2 groups : invasive and non invasive infections. (blogspot.com)
- Not only does this dramatically change the types of data routinely obtained from clinical samples [ 6 ], but it provides greater insight to microbial community structure, function, dynamics, and the interspecies interactions that are central to explaining how the human microbiota functions to maintain host health or predispose individuals to diseases [ 7 - 9 ]. (hindawi.com)
- In this respect, H. influenzae cultured from the nasopharyngeal cavity or sputum would not indicate H. influenzae disease, because these sites are colonized in disease-free individuals. (wikipedia.org)
- H. influenzae Gram stain of a sputum sample, appear as Gram negative cocco-bacilli. (thefullwiki.org)
- The current GAS classification system, known as emm -typing, is based on sequencing of 10-15% of the emm gene (which encodes the M protein) with 223 emm -types identified worldwide [ 12 , 13 ]. (hindawi.com)
- Recently, a new adjunct method of classification, known as the " emm -cluster system" has been developed, which organizes the 223 emm -types into 48 distinct emm -clusters based on the phylogenetic analysis of the whole M protein and its structural and binding properties [ 14 - 16 ]. (hindawi.com)
- Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly known as pink eye. (wikipedia.org)
- During the mid-1980s to early 1990s, a highly virulent clonal group of Haemophilus aegyptius, localized in and around the São Paulo State of Brazil, was found to be responsible for Brazilian purpuric fever, an acute septicemic fulminant illness affecting children. (wikipedia.org)
- Haemophilus aegyptius was first observed by Koch in 1883. (wikipedia.org)
- In 1892, Pfeiffer discovered H. influenzae, raising some confusion over whether H. aegyptius was different from H. influenzae. (wikipedia.org)
- In order to account for both the similarities and differences, H. aegyptius has been classified as a biogroup of H. influenzae. (wikipedia.org)
- Scientists were able to isolate H. influenzae biogroup aegyptius after studying the blood and cerebrospinal fluids of affected children. (wikipedia.org)
- After discovering another, and very similar, outbreak in Londrina (located a little under 200 miles from Promissao), scientists determined that a single H. influenzae biogroup aegyptius clone is responsible for all cases of BPF. (wikipedia.org)
- Naturally acquired disease caused by H. influenzae seems to occur in humans only. (wikipedia.org)
- The implementation of the Hib vaccine, targeting the major capsule type of H. influenzae , almost eradicated the disease in countries that adapted the vaccination scheme. (microbiologyresearch.org)
- Invasive Haemophilus influenzae type f disease. (microbiologyresearch.org)
Classified by multilocus1
- There are six distinct antigenic serotypes of encapsulated H. influenzae designated a-f on the basis of their capsular polysaccharide. (springer.com)
- Serological testing demonstrates the capsular polysaccharide, which is usually of the b type as it's the most common to cause infections. (bionity.com)
- Several factors may influence the subclass pattern of the antibody response in infections, important among which are the type of antigen (whether proteins or polysaccharides) ( 6 , 29 ), the age of the individual ( 13 ), and exposure to the antigens and the site of induction of the immune response ( 7 ). (asm.org)
- Reporter Antigen Popliteal Lymph Node Assay Rabbit Rabbit Immune System Rabbit Immune System Rose G Mage Molecular Immunogenetics Section Laboratory of Immunology NIAID Building N 11, MSC 1892 NIH, 10 Center Drive Bethesda, MD USA Characteristics An extensive review of the rabbit immune system has been published previously (1). (docplayer.net)
- Bacterial culture of H. influenzae is performed on agar plates, the preferable one being chocolate agar, with added X (hemin) and V (nicotinamide adenine dinucleotide) factors at 37 °C in a CO2-enriched incubator. (wikipedia.org)
- H. influenzae on a blood agar plate. (meddic.jp)
- Bacterial culture of H. influenzae is performed on agar plates, preferably Chocolate agar , plate with added X (Hemin) & V (NAD) factors at 37°C in an enriched CO2 incubator. (thefullwiki.org)
- Also, growth on blood agar would show the satellitism phenomenon, which is the growth of H. influenzae around a streak of S. aureus line of growth. (bionity.com)
- is streaked across a plate of blood agar, on which H. influenzae too inoculated. (blogspot.com)
- Levinthal's Medium or by adding a peptic digest of blood to nutrient agar - Fildes Agar , which is best for primary isolation of H. influenzae and gives a vast growth. (blogspot.com)
- The outermost structure of encapsulated H. influenzae is composed of a polysaccharide, a key virulence factor. (cdc.gov)
- A report published in early 2003 noted that Type A influenza virus has a high potential for use as such an agent because of the virulence of the Type A strain that broke out in Hong Kong in 1997 and the development of laboratory methods for generating large quantities of the virus. (encyclopedia.com)