A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
A condition in infancy or early childhood due to an in-utero deficiency of THYROID HORMONES that can be caused by genetic or environmental factors, such as thyroid dysgenesis or HYPOTHYROIDISM in infants of mothers treated with THIOURACIL during pregnancy. Endemic cretinism is the result of iodine deficiency. Clinical symptoms include severe MENTAL RETARDATION, impaired skeletal development, short stature, and MYXEDEMA.
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Sensitivity and Specificity
Tandem Mass Spectrometry
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Aldosterone synthase deficiency type I with no documented homozygous mutations in the CYP11B2 gene. (1/16)This case report concerns a girl born from non-consanguineous parents and hospitalized in another hospital at the age of 14 days because of a severe salt-losing syndrome (Na=125, K=8.6 mEq/l). In spite of normal genitalia, diagnosis of 21-hydroxylase deficiency was assessed on the basis of a slightly increased 17-OH-progesterone serum level (6.4 ng/ml). The onset of both hydrocortisone and 9alpha-fluorohydrocortisone therapy was followed by a resolution of the clinical picture. At the age of 60 days she was admitted to our clinic for a re-evaluation of the diagnosis. Steroid hormone serum levels were measured after withdrawal of therapy and diagnosis of corticosterone methyl oxidase (CMO) deficiency type I was definitely established in the light of the biochemical results: i.e. very low 18-hydroxycorticosterone (18-OH-B) serum levels (20 pg/ml), an abnormally high corticosterone/18-OH-B serum ratio (306.5) and an abnormally low 18-OH-B/aldosterone serum ratio (2.1). This autosomal recessively inherited disorder can be differentiated from CMO type II and other salt-wasting syndromes only on the basis of the serum steroid hormone pattern. After establishing the diagnosis of CMO I deficiency, hydrocortisone therapy was withdrawn whilst treatment with 9alpha-fluorohydrocortisone was begun again, with a satisfactory clinical and metabolic impact. Direct sequences of the patient's DNA were able to identify only a (heterozygous) amino acid substitution in exon 7 of that gene, which is known to have only a small effect on enzyme activity and cannot be the only cause of the patient's phenotype: valine-386-alanine (V386A) GTG-->GcG. No homozygous mutations in the CYP11B2 gene were observed. This is the first report of a patient with CMO type I who does not carry any homozygous mutation in the entire CYP11B2 alleles, whereas some cases with no mutations in this gene have already been reported in CMO II. The present study seems to be inconsistent with the previously reported correlation of the phenotype and genotype in CMO type I. A reasonable question that might be raised on the basis of our findings in this case report is whether other genes, apart from CYP11B2, are involved in the regulation of terminal aldosterone synthesis. (+info)
Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences. (2/16)Using in vitro and in vivo methods, we have demonstrated increased sensitivity of adrenocortical steroidogenesis to ACTH in Milan hypertensive (MHS) compared with normotensive (MNS) rats and have investigated whether this is caused by mutations of steroidogenic enzymes. Genes encoding aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) in MHS and MNS have been cloned and sequenced. Nucleotide 752 (G) in exon 4 of MHS CYP11B2 differs from that of MNS (A); CYP11B1 sequences were identical. The nucleotide 752 mutation caused a Q251R substitution in the amino acid sequence of MHS CYP11B2. The phenotype of MHS CYP11B2 alleles, when expressed in COS-1 cells, differed from that of MNS alleles. The relative activities of the three reactions catalyzed by CYP11B2 (11beta-hydroxylation of deoxycorticosterone, 18-hydroxylation of corticosterone, and dehydrogenation of 18-hydroxycorticosterone) were estimated after incubation of transfected cells with [(14)C]deoxycorticosterone and analysis of radioactivity associated with deoxycorticosterone, corticosterone, 18 hydroxycorticosterone, and aldosterone. Both 11- and 18-hydroxylase activities were lower (19 and 12%, respectively; P < 0.01 and P < 0.05) in cells transfected with MHS compared with MNS alleles, whereas 18-oxidase activity was 42% higher (P < 0.01). To assess the significance of the CYP11B2 mutation in vivo, DNA from F2 hybrid MHS x MNS rats was genotyped. MHS alleles were associated with lower urine volumes in both sexes, lower ventricle weights in male rats, but no difference in systolic or diastolic blood pressures between the sexes. We conclude that a mutation in CYP11B2 may affect aldosterone secretion in MHS; however, under normal environmental circumstances, we were unable to demonstrate any influence of this mutation on blood pressure. (+info)
Stereological and functional investigations on isolated adrenocortical cells. III. Zona glomerulosa cells of chronically ACTH-treated rats. (3/16)Prolonged (5 day) treatment of rats with high doses of ACTH caused a significant reduction in the plasma concentration of aldosterone and a notable rise in that of corticosterone. Outer subcapsular (zona glomerulosa [ZG]) adrenocortical cells were isolated, and their morphology and secretory activity was investigated. ACTH pretreatment induced a marked hypertrophy of ZG cells which was coupled with significant increases in the volume of the mitochondrial compartment and in the surface area per cell of mitochondrial cristae and AER tubules, as well as with a striking lipid droplet depletion. Mitochondrial cristae were found to change from a tubulo-laminar to a tubulo-convolute configuration. Despite their hypertrophy, ZG cells from ACTH-pretreated rats displayed a conspicuous decrease in both basal and stimulated overall production of post-pregnenolone steroids, which was ascribed to the depletion of their stores of steroid hormone precursors (i.e. cholesterol and cholesterol esters contained in the lipid droplets). However, both basal and stimulated secretion of aldosterone was doubled, suggesting that chronic ACTH treatment induces in ZG cells an increased availability of monoxygenase II, the enzyme involved in the transformation of 18-hydroxycorticosterone into aldosterone. In the light of these findings, the drop in the plasma level of aldosterone observed in rats after prolonged treatment with ACTH is assumed to be due to an enhanced metabolism of aldosterone, possibly at the hepatic level. (+info)
Altered responses of plasma 18-hydroxycorticosterone and aldosterone to angiotensin II and adrenocorticotropin in patients with a 18-hydroxycorticosterone-producing tumor. (4/16)Plasma 18-hydroxycorticosterone (18-OHB) and aldosterone responses to angiotensin II (AII) and ACTH were examined in 2 patients with a 18-OHB-producing tumor (18-OHBPT) versus those in 8 patients with a aldosterone-producing adenoma (APA), 7 patients with low renin essential hypertension (LREH) and 10 normal subjects. Plasma 18-OHB and aldosterone levels and the 18-OHB: aldosterone ratio were high in patients with an APA and normal in patients with LREH. In patients with a 18-OHBPT, plasma 18-OHB and aldosterone levels were high and normal, respectively, resulting in a 2-fold greater 18-OHB: aldosterone ratio than that in patients with an APA. Patients with an APA had a blunted response of plasma 18-OHB and aldosterone to AII and a supranormal response of these corticoids to ACTH. Patients with LREH had a supranormal response of plasma 18-OHB and aldosterone to AII and a normal response of these corticoids to ACTH. In patients with a 18-OHBPT the responses of both plasma 18-OHB and aldosterone to AII and ACTH closely resembled those in patients with an APA but not in patients with LREH. These data suggest that 18-OHBPT may be a variant of aldosteronomas, producing a large amount of 18-OHB and a small amount of aldosterone. (+info)
Effects of corticotropin-releasing factor (CRF) on aldosterone and 18-hydroxycorticosterone in essential hypertension and primary aldosteronism. (5/16)The effects of ovine corticotropin releasing factor (o-CRF) on plasma aldosterone, 18-OH-corticosterone (18-OHB), plasma adrenocorticotropin (ACTH) and cortisol were determined in eight patients with primary aldosteronism, six with aldosterone-producing adenoma (APA) and two with idiopathic hyperaldosteronism (IHA). The results were compared with those in six normal subjects and eleven patients with essential hypertension (EHT, 5 with low renin and 6 with normal renin). In patients with APA, the peak plasma aldosterone and 18-OHB responses to 100 micrograms iv of o-CRF (226% and 113% increase from baseline, respectively) were greater than those in EHT and normal subjects. The net integrated aldosterone and 18-OHB responses (840 +/- 156, and 419 +/- 121 ng/dl.hr, respectively) were also significantly greater (p less than 0.01) in APA than those in normals and EHT. In two patients with IHA, both the peak and net integrated aldosterone response were smaller than those in APA, in spite of nearly identical plasma ACTH and cortisol responses. These results suggest that augmented responses of mineralocorticoids to o-CRF may be characteristic of aldosteronism due to APA, mediated by CRF-induced ACTH, and possibly other proopiomelanocortin (POMC)-derived peptides. (+info)
The renal, cardiovascular and hormonal actions of human atrial natriuretic peptide in man; effects of indomethacin. (6/16)The renal, cardiovascular and hormonal effects of intravenous infusion of alpha-human atrial natriuretic polypeptides (alpha-hANP) at the concentrations of 0.0125, 0.025, 0.05, 0.1 microgram kg-1 min-1 for 20 min was studied in six male volunteers before and after indomethacin administration (150 mg day-1, three times daily for 3 days). Dose-dependent diuresis and natriuresis were observed in all subjects between the concentrations of 0.025 and 0.1 microgram kg-1 min-1, which were not influenced by indomethacin. Diastolic blood pressure decreased significantly (P less than 0.05) at the higher dose (0.05 microgram kg-1 min-1) of alpha-hANP, which was attenuated by indomethacin pretreatment. The plasma concentration of the immunoreactive alpha-hANP was 73.7 +/- 25 pg ml-1 on the control in subjects taking 200 mEq day-1 of sodium, and significant diuresis occurred when plasma concentration reached approximately 330.5 +/- 74.4 pg ml-1. alpha-hANP infusion caused a dose-dependent increase in cyclic GMP, no significant changes in plasma aldosterone and 18-hydroxycorticosterone, which were not influenced by indomethacin pretreatment. Plasma renin did not change in response to alpha-hANP infusion, which was significantly decreased (P less than 0.05) after indomethacin pretreatment. These results support that the renal effects of alpha-hANP may be exerted by prostaglandin-independent mechanisms. The renal effects occur at lower doses, and cardiovascular changes occur at higher doses of alpha-hANP. (+info)
An adrenocortical tumor secreting weak mineralocorticoids. (7/16)An adrenocortical carcinoma (15.5 g) secreting excessive amounts of steroids with weak mineralocorticoid activity in a 25-year-old woman was studied with particular reference to its in vivo and in vitro secretions of steroids. Severe hypertension, occasional low serum potassium and suppressed PRA were the major clinical findings, and were improved with removal of the tumor. In the preoperative stage, plasma levels of 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone, corticosterone and 18-hydroxycorticosterone were all increased. However, the plasma level of aldosterone was repeatedly normal. Although plasma levels of pregnenolone, 17-hydroxypregnenolone, progesterone and 17-hydroxyprogesterone were very high, those of other late step steroids, i.e. 11-deoxycortisol, cortisol, dehydroepiandrosterone, androstenedione and testosterone were almost normal. From these findings, a major etiological role of weak mineralocorticoids such as 11-deoxycorticosterone, 18-hydroxycorticosterone and corticosterone in her hypertension was suggested. Pregnenolone and 17-hydroxypregnenolone in tumor tissue were increased, but 11-deoxycorticosterone, corticosterone, aldosterone, cortisol and adrenal androgens such as dehydroepiandrosterone, androstenedione and testosterone were below normal or low normal. In vitro production of 11-deoxycorticosterone, aldosterone or cortisol by the tumor tissue slices was very low and scarcely responded to synthetic ACTH. (+info)
Adrenal steroid responses to ACTH in glucocorticoid-suppressible aldosteronism. (8/16)To investigate adrenal responses to adrenocorticotrophin (ACTH), we infused graded doses of ACTH (1.25 to 20.0 mIU/30 minutes) in normal subjects, patients with low-renin essential hypertension (LREH), primary aldosteronism (PA), and glucocorticoid-suppressible hyperaldosteronism (GSH). Plasma aldosterone, cortisol, corticosterone, and 18-hydroxycorticosterone were measured. The results revealed a greater increase in the plasma aldosterone and 18-hydroxycorticosterone levels evoked by ACTH in the GSH group than in any other group, which suggested enhanced responsiveness of the aldosterone-producing cells to ACTH and a probable adrenal abnormality. (+info)
17ß-hydroxycorticosterone synonyms, 17ß-hydroxycorticosterone antonyms - FreeThesaurus.com
Synonyms for 17ß-hydroxycorticosterone in Free Thesaurus. Antonyms for 17ß-hydroxycorticosterone. 3 synonyms for cortisol: Cortef, hydrocortisone, Hydrocortone. What are synonyms for 17ß-hydroxycorticosterone?
Adrenal venous blood was collected from hypophysectomized and sham-hypophysectomized dogs 6 days postoperatively. 17-Hydroxycorticosterone, corticosterone, 11-desoxy-17-hydroxycorticosterone and aldosterone were isolated by paper chromatography. Histological examination of the sellar and suprasellar regions of the hypophysectomized dogs demonstrated the absence of pituitary tissue. The adrenal glands of the hypophysectomized dogs showed cortical atrophy which did not involve the zona glomerulosa. The rate of secretion of aldosterone by the hypophysectomized dogs was found to be approximately 66% of that of the control, sham hypophysectomized, dogs. The rates of secretion of 17-hydroxycorticosterone, corticosterone and 11-desoxy-17-hydroxycorticosterone were found to be approximately 10% of that of the controls. The ability of the hypophysectomized dog to remain in electrolyte balance appears to be due in large measure to the continued secretion of aldosterone.. ...
18 hydroxycorticosterone - Answers on HealthTap
Not specific: The signs & symptoms of hypothyroidism are not specific for hypothyroidism (not a single one). Recheck your thyroid labs. If theyre normal, your symptoms are due to something else. Having said that, Im happy to do a trial of Cytomel with the Synthroid (thyroxine) in patients who want to try as long as I dont make them hyperthyroid. Some people report feeling better with comparable labs taking a little T3. ...Read more See 1 more doctor answer ...
Measurement of Peripheral Plasma 18-Oxocortisol Can Discriminate Unilateral Adenoma From Bilateral Diseases in Patients With...
In this study, the LC-MS/MS intra-assay accuracy and precision were 90% to 111% and 3% to 9% for 18OHF and 18oxoF, respectively. Those of interassay were 87% to 108% and 1% to 10% for 18OHF and 18oxoF, respectively. The lower limits of quantification of 18OHF and 18oxoF were 2.5 and 0.25 ng/dL, respectively. The 3% to 9% precision of LC-MS/MS indicated, therefore, that this method was considered as a reliable mode of measurement in this setting. Further to this, the cut-off value was higher than the lower limit of quantification. Thus, we think that precision of the measurement method was demonstrated by the results obtained. Likewise, the sensitivity and the specificity of the cut-off value were influenced by the precision of the measurement method. Nevertheless, it is entirely true that the 3% to 9% precision of this method indicated that the clinical diagnosis of AP should be carefully performed in patients whose 18OHF and 18oxoF values are around the cut-off value.. 18-Hydroxycorticosterone ...
Aldosterone Synthase - CYP11B2 Summary Report | CureHunter
Aldosterone Synthase: A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
ke ni shang qi, Complementary and Alternative Healing University 球仧丫藥辴具
English - Chinese Bio-chemistry Dictionary. By: Joe Hing Kwok Chu. Back to Biochemistry Dictionary Main page. Adrenocortical Hormone, Page 1 Page 1 (index 11-deoxycortisol~18-hydroxycorticosterone). page 2 (3b-hydroxydehydrogenase~cardiac inhibiting factor). page 3 (circadian rhythms ~ dexamethasone). page 4 (metyrapone test ~ stress reaction). page 5 (tetrahydrocortisol ~ water test). Go to Next page ...
Selective modification of renal alpha 2-adrenergic receptors in Milan hypertensive rat strain. | Hypertension
Cerebral and renal alpha-adrenergic receptors play an important role in the control of blood pressure. We studied alpha-adrenergic receptors in the cerebral and renal cortex of Milan hypertensive strain (MHS) and normotensive strain (MNS) rats, a genetic model of spontaneous hypertension linked to a kidney abnormality. Binding of the selective alpha 1-adrenergic antagonist [3H]prazosin and the alpha 2-adrenergic antagonist [3H]rauwolscine was used for receptor studies in tissues of prehypertensive (24-day-old) and hypertensive (60-day-old) rats. In the cerebral cortex, no between-strain differences in alpha 1-adrenergic and alpha 2-adrenergic receptor density and affinity were observed in prehypertensive and hypertensive periods. The density of these receptors increased similarly with age in MHS and MNS rats. In the renal cortex, the differences between MHS and MNS rats concerned alpha 2-adrenergic receptors only. Compared with their age-matched normotensive controls, MHS rats showed 1) a lower ...
Milan | Italy | Britannica.com
Milan: Milan, city, capital of Milano province (provincia) and of the region (regione) of Lombardy (Lombardia), northern Italy. It is the leading financial centre and the most
Milan, Italy Fashion Events | Eventbrite
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What does 11-deoxycorticosterone mean?
Definition of 11-deoxycorticosterone in the Definitions.net dictionary. Meaning of 11-deoxycorticosterone. What does 11-deoxycorticosterone mean? Information and translations of 11-deoxycorticosterone in the most comprehensive dictionary definitions resource on the web.
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JCI - Metabolism of deoxycorticosterone and deoxycorticosterone sulfate in men and women.
In this investigation we found that little of intravenously infused [14C]deoxycorticosterone (DOC) was converted to [14C]DOC-SO4 that entered plasma. Moreover little of intravenously infused [3H]DOC-SO4 was metabolized by way of DOC except by intestinal bacterial enzymes. However evidence was obtained that plasma DOC is converted to DOC-SO4 in liver, but little of the DOC-SO4 formed in liver escapes into blood; rather the DOC-SO4 enters bile and in the intestine is converted, in part, to progesterone (or metabolites thereof) by the action of bacterial enzymes. The estimated intrahepatic fractional conversion of DOC to DOC-SO4 was significantly greater in premenopausal women (0.72 +/- 0.118, mean +/- SEM) than in men (0.28 +/- 0.036, P less than 0.005).. ...
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Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies
ROMK, NKCC2, and NCCT mutations usually have uniform clinical presentations, whereas mutations in ClC-Kb occasionally lead to phenotypic overlaps with the NCCT or, less commonly, with the ROMK/NKCC2 cohort. Based on these results, we propose an algorithm for the molecular diagnosis of hypokalemic sa …
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Mokrejš, Pavel; Sukop, Svatopluk; Janáčová, Dagmar; Mládek, Milan; Langmaier, Ferdinand; Kolomazník, Karel (Česká společnost chemická (ČSCH), 2006) ...
Exposure-route-dependent DNA adduct formation by polycyclic aromatic hydrocarbons : Carcinogenesis - oi
Understanding the kinetics of aromatic-DNA adducts in target tissues and white blood cells (WBC) would enhance the applicability of DNA adducts in WBC as surrogate source of DNA in biomonitoring studies. In the present study, rats were acutely exposed to benzo[a]pyrene (B[a]P; 10 mg/kg body wt) via intratracheal (i.t.), dermal and oral administration. DNA adducts were analyzed in relevant target organs and WBC by nuclease P1 enriched 32P-post-labeling at 1, 2, 4, 11 and 21 days after exposure. Additionally, the internal dose was assessed by measurement of urinary excretion of 3-hydroxy-B[a]P (3-OH-B[a]P). Total B[a]P-DNA adduct levels in WBC were highest after i.t. and oral administration, whereas DNA adducts were hardly detectable after dermal exposure. Highest adduct levels were reached at 2 days after exposure. In lung tissue, DNA adduct levels reached maximal values at 2 days and were highest after i.t., oral and dermal exposure, respectively. DNA adduct levels were significantly lower in ...
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Shorn of stars Juventus, AC Milan still cruise in Italian Cup
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AC Milan Holding Company Fininvest Calls Sale Reports Totally Unfounded - SportsBusiness Daily | SportsBusiness...
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18-Hydroxycortisol 18-Hydroxycorticosterone "Familial hyperaldosteronism". Genetics home reference. April 2014. Retrieved 8 ...
Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency
Consequently, levels of DOC, corticosterone, and 18-hydroxycorticosterone are elevated. Although these precursors of ...
List of steroid abbreviations
18 (1): 117-24. doi:10.1046/j.1460-9568.2003.02734.x. PMID 12859344. Labrie C, Simard J, Zhao HF, Belanger A, Pelletier G, ... 2007). "Measurement of 18-Hydroxycorticosterone During Adrenal Vein Sampling for Primary Aldosteronism". Journal of Clinical ...
... is an endogenous steroid. 18-hydroxycortisol has been proposed as a biomarker for certain diseases. In ... Cortisol 18-Hydroxycorticosterone Aldosterone synthase Steroid 11β-hydroxylase Lenders J, Williams T, Reincke M, Gomez-Sanchez ... In healthy subjects, the biosynthesis of 18-hydroxycortisol is low. The highest synthesis of 18-hydroxycortisol was found in ... Chiba H (July 2010). "18-Hydroxycortisol, 18-oxocortisol, and 6beta-hydroxycortisol". Nihon Rinsho. Japanese Journal of ...
18 (1): 41-78. doi:10.1089/vim.2005.18.41. PMC 1224723. PMID 15802953. Robson PJ, Blannin AK, Walsh NP, Castell LM, Gleeson M ( ... 18 (4): 301-9. PMID 3084123. Mikosha AS, Pushkarov IS, Chelnakova IS, Remennikov GY (1991). "Potassium Aided Regulation of ... I 18-hydroxylation and 18hydroxy dehydrogenation. II beta-hydroxylation". Acta Endocrin. Copenh. 69 (4): I 701-717, II 718-730 ... "The effect of sodium deprivation and of angiotensin II infusion on the peripheral plasma concentrations of 18- ...
In humans, 18-OH-DOC is a weak mineralocorticoid. It may be increased in 17α-hydroxylase (CYP17A1) deficiency, in aldosterone ... Excessive secretion of 18-OH-DOC can cause mineralocorticoid excess syndrome, although these cases are very rare. Fujii S, ... 18-Hydroxy-11-deoxycorticosterone (also known as 18-OH-DOC, 18,21-dihydroxyprogesterone, and 18,21-dihydroxypregn-4-ene-3,20- ... 18-hydroxydeoxycorticosterone at the US National Library of Medicine Medical Subject Headings (MeSH) v t e. ...
List of corticosteroids
18-hydroxypregn-4-ene-3,20-dione  21-Deoxycortisol = 11β,17α-dihydroxypregn-4-ene-3,20-dione, 21-Deoxycortisone = 17α- ... 18,20-trione Corticosterone (17-deoxycortisol) = 11β,21-dihydroxypregn-4-ene-3,20-dione Cortisol (hydrocortisone) = 11β,17α,21- ... 18,21-dihydroxypregn-4-ene-3,20-dione  18-Hydroxycorticosterone = 11β,18,21-trihydroxypregn-4-ene-3,20-dione 18- ...
In enzymology, a corticosterone 18-monooxygenase (EC 220.127.116.11) is an enzyme that catalyzes the chemical reaction ... The systematic name of this enzyme class is corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating ... 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O The 3 substrates of this enzyme are corticosterone, reduced ... whereas its 3 products are 18-hydroxycorticosterone, oxidized adrenal ferredoxin, and H2O. This enzyme belongs to the family of ...
List of MeSH codes (D06)
18-hydroxydesoxycorticosterone MeSH D06.472.040.585.745 - pregnenolone MeSH D06.472.040.585.745.500 - 17-alpha- ... 18-hydroxycorticosterone MeSH D06.472.040.585.353.825 - tetrahydrocortisol MeSH D06.472.040.585.478 - 17-hydroxycorticosteroids ...
... a corticosteroid 5α-Dihydroaldosterone Dihydrocortisone Hydrocortisone Humulone 18-Hydroxycorticosterone Isohumulone This set ...
List of MeSH codes (D04)
18-hydroxycorticosterone MeSH D04.808.745.745.654.252 - cortodoxone MeSH D04.808.745.745.654.339 - desoxycorticosterone MeSH ... D04.808.745.745.654.339.400 - 18-hydroxydesoxycorticosterone MeSH D04.808.745.745.654.473 - flurandrenolone MeSH D04.808. ...
The weak 18-hydroxylase activity of CYP11B1 explains why an adrenal with suppressed CYP11B2 expression continues to synthesize ... 18 (11): 13228-44. doi:10.3390/molecules181113228. PMC 6270415. PMID 24165582. Freel EM, Shakerdi LA, Friel EC, Wallace AM, ... Nicod J, Dick B, Frey FJ, Ferrari P (February 2004). "Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18- ... Fisher A, Friel EC, Bernhardt R, Gomez-Sanchez C, Connell JM, Fraser R, Davies E (September 2001). "Effects of 18-hydroxylated ...
... serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the ... 18-Hydroxycortisol Aldosterone synthase Reddish MJ, Guengerich FP (August 2019). "Human cytochrome P450 11B2 produces ... 18-Hydroxycorticosterone is an endogenous steroid. It is a derivative of corticosterone. ... Izumi Y (July 2010). "[18-Hydroxycorticosterone (18-OH-B)]". Nihon Rinsho. Japanese Journal of Clinical Medicine (in Japanese ...
The 18-hydroxylase activity consists in catalyzing sequential hydroxylations of the steroid angular methyl group at C18. ... May 1997). "CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase ( ... Aldosterone synthase is the enzyme that has steroid 18-hydroxylase activity as well as steroid 11 beta-hydroxylase activity. ... The corticosterone methyl oxidase deficiencies both share this effect however type I causes an overall deficiency of 18- ...
InChI=1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-, ... This page was last edited on 20 June 2020, at 18:48 (UTC). ...
C-18: Estrane). 1. 2-Hydroxyestrone ← Estrone → 16α-Hydroxyestrone → 15α,16α-Hydroxyestrone. 2. 2-Hydroxyestradiol ← Estradiol ... InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-17,20-21H,4-11H2,1-2H3/t13-,14-,15-, ...
InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-, ... Jong Rho; Raman Sankar; Carl E. Stafstrom (18 June 2010). Epilepsy: Mechanisms, Models, and Translational Perspectives. CRC ...
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-, ... 18] 16α-OH-DHEA-S is then taken up by the placenta. Due to high expression of steroid sulfatase in the placenta, 16α-OH-DHEA ...
18 (10-37) pg/mL. 26 (17-58) pg/mL. 36 (23-69) pg/mL. 44 (30-89) pg/mL. 75 (39-160) pg/mL. ND. ND. ND. ND. ND. ND ... InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-, ... Jameson JL, De Groot LJ (18 May 2010). Endocrinology: Adult and Pediatric. Elsevier Health Sciences. pp. 2812-. ISBN 978-1-4557 ... 18 µg/day. 5-20 pg/mL. 30-70 pg/mL. 0.3-0.8 ... 18] Suppression of estradiol production in a subpopulation of ...
InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+ ... InChI=1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15-,16+, ...
In males, estrogen regulates certain functions of the reproductive system important to the maturation of sperm and ... This page was last edited on 18 November 2018, at 16:34 (UTC). ...
CHEBI:16485 - 18-hydroxycorticosterone. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... 18-hydroxycorticosterone (CHEBI:16485) is a 3-oxo steroid (CHEBI:47788) 18-hydroxycorticosterone (CHEBI:16485) is a primary α- ... 18-hydroxycorticosterone (CHEBI:16485) is a 11β-hydroxy steroid (CHEBI:35346) 18-hydroxycorticosterone (CHEBI:16485) is a 18- ... 18-hydroxycorticosterone (CHEBI:16485) is a 20-oxo steroid (CHEBI:36885) 18-hydroxycorticosterone (CHEBI:16485) is a 21-hydroxy ...
18-Hydroxycorticosterone - Wikipedia
18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the ... 18-Hydroxycortisol Aldosterone synthase Reddish MJ, Guengerich FP (August 2019). "Human cytochrome P450 11B2 produces ... 18-Hydroxycorticosterone is an endogenous steroid. It is a derivative of corticosterone. ... Izumi Y (July 2010). "[18-Hydroxycorticosterone (18-OH-B)]". Nihon Rinsho. Japanese Journal of Clinical Medicine (in Japanese ...
18 hydroxycorticosterone - Answers on HealthTap
I have a question if my due date is may 18 2013 and last menstrual was august 11 what day did i conceive? I will be exactly 3 ... On day 18 of bydureon (exenatide) with higher sugars. Shouldnt i see an improvement by now? ... 18 years with high cholesterol, hyperlipidema, can we give Milo with pastuerised milk once a day ? ... Im 18, and I have a hunch back is their anyway I can fix it? ... 18 What is the purpose of an mmpi? And how do you interprit the ...
Human Metabolome Database: Showing metabocard for 18-Hydroxycorticosterone (HMDB0000319)
Showing metabocard for 18-Hydroxycorticosterone (HMDB0000319). Jump To Section: IdentificationTaxonomyOntologyPhysical ... 18-Hydroxycorticosterone. Description. 18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone. If it ... Kooner JS, Few JD, Lee CY, Taylor GM, James VH: Investigation of the salivary 18-hydroxycorticosterone:aldosterone ratio in man ... In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have ...
18-Hydroxycorticosterone - What does 18-Hydroxycorticosterone stand for? The Free Dictionary
Looking for online definition of 18-Hydroxycorticosterone or what 18-Hydroxycorticosterone stands for? 18-Hydroxycorticosterone ... 18-OHB. (redirected from 18-Hydroxycorticosterone). Also found in: Wikipedia. Acronym. Definition. ... 18 year old picked up by cops walking home from party, intoxicated ... corticosterone and 18-hydroxycorticosterone) by the adrenal cortex.. Two cousins with 17-alpha hydroxylase deficiency/ 17 alfa ...
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Trypsin stimulation of aldosterone and 18-hydroxycorticosterone production by rat adrenal zona glomerulosa tissue is mediated...
Aldosterone and 18-hydroxycorticosterone were strongly, and corticosterone moderately, affected, while the production of 18- ... Aldosterone and 18-hydroxycorticosterone were strongly, and corticosterone moderately, affected, while the production of 18- ... Trypsin stimulation of aldosterone and 18-hydroxycorticosterone production by rat adrenal zona glomerulosa tissue is mediated ... Trypsin stimulation of aldosterone and 18-hydroxycorticosterone production by rat adrenal zona glomerulosa tissue is mediated ...
In vitro uptake of 18-hydroxycorticosterone by regions of the central nervous system | Acta physiol. pharmacol. ther. latinoam...
Encontramos que 18-OH-B tiene una mayor unión específica a núcleos obtenidos de bulbo y protuberancia; este perfil difiere de ... Index: LILACS (Americas) Main subject: Subcellular Fractions / In Vitro Techniques / Central Nervous System / 18- ... Hydroxycorticosterone Limits: Animals Language: English Journal: Acta physiol. pharmacol. ther. latinoam Journal subject: ... Index: LILACS (Americas) Main subject: Subcellular Fractions / In Vitro Techniques / Central Nervous System / 18- ...
DISTINCTIVE PLASMA-ALDOSTERONE, 18-HYDROXYCORTICOSTERONE, and 18-HYDROXYDEOXYCORTICOSTERONE PROFILE in the 21-HYDROXYLASE, 17...
3,8-dimethylundecane - Ontology Browser - Rat Genome Database
LIPID MAPS Lipid Structure Database (LMSD) : LIPID MAPS Lipidomics Gateway
18-Hydroxycorticosterone (W). 11β,18,21-trihydroxy-pregn-4-ene-3,20-. dione. C21H30O5. 362.2093. ... 13-ethyl-17α-hydroxy-18,19-dinorpregn-. 4-en-20-yn-3-one. C21H28O2. 312.2089. ... 13-ethyl-11-methylene-18,19-dinorpregn-. 4-en-20-yn-17α-ol. C22H30O. 310.2297. ... 18xi,21-dihydroxy-11β,18-epoxypregn-4-. ene-3,20-dione. C21H28O5. 360.1937. ...
Familial hyperaldosteronism - Wikipedia
Aldosterone and Renin | SpringerLink
Biglieri, E. G., and Schambelan, M., 1979, Significance of elevated levels of plasma hydroxycorticosterone in patients with ... I. Significance of 18-hydroxy-11-deoxycorticosterone, Am. J. Cardiol. 38: 814-824.PubMedCrossRefGoogle Scholar ... 18.. Chrousos, C. P., Vingerhoeds, A., Brandon, D., de Regt, J., Pugeat, M., Eli, C., Loriaux, D. L., and Lipsett, M. B., 1981 ... Sonino, N., Levine, L. S., Vecsei, P., and New, M. I., 1980, Parallelism of 1113 and 18-hydroxylation demonstrated in urinary ...
Classical pathway of steroidogenesis, including diseases (Homo sapiens) - WikiPathways
18-hydroxycorticosterone. 11-Deoxycortisol. POR. 3-beta-HSD. P450c21. Androstenedione. 3-beta-HSD. P450c11. P450c17. P450c17. 3 ... 18. 3-beta-HSD type II deficiency. 15. 19. 21-Hydroxylase deficiency. 12. 11-beta-hydroxylase type I deficiency. Corticosterone ... 15:18, 17 February 2019. DeSl. Changed arrows for diseases to graphical lines; small layout changes.. 103196. view. 15:36, 15 ... 18-hydroxycorticosterone. mim-conversion. RHEA:11873 (Rhea) Cortisol. Cortisone. mim-conversion. RHEA:53117 (Rhea) Cortisone. ...
Glucocorticoid & Mineralcorticoid Metabolism (Mus musculus) - WikiPathways
5b-Pregnan-18-al. OH. C. O. OH. C. =O. 3. From Cholersterol Biosynthesis. Steroid Hormone. Signaling. =O. 3. CH. 3. CH. CH. HO ... 5b-Pregnan-18-al. O. OH. 3B-OH-delta-Steroid Dh. Urocortisone. HO. have strucutures shown. =O. CH. 3a,11b,21-Trihydroxy-20-Oxo- ... 18-Hydroxycorticosterone. 17a-Hydroxypregnenolone. Hsd3b2. Corticosterone. Cholesterol. Cyp21a1. 17alpha,21-Dihydroxy-5beta- ... 18:16, 8 July 2013. MaintBot. Updated to 2013 gpml schema. 67283. view. 10:31, 26 June 2013. Christine Chichester. Ontology ...
Involvement of Prostaglandins in the Actions of Captopril | Clinical Science | Portland Press
Plasma renin activity (PRA) increased (P , 0.002), and plasma and urinary aldosterone as well as plasma 18- ... hydroxycorticosterone (18- OH-B) decreased after captopril (P , 0.02). Prostaglandin (PG) E2, kallikrein, urine volume, sodium ... Evaluation of the Mineralocorticoid Activity of 18-Hydroxycorticosterone Clin Sci (Lond) (August,1981) ... Aldosterone did not decrease further after captopril, and 18-OH-B fell only slightly. ...
The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester | SpringerLink
18.. Xita N, Tsatsoulis A. Fetal origins of the metabolic syndrome. Ann N Y Acad Sci. 2010;1205:148-55.CrossRefPubMedGoogle ... The conversion of 11-deoxycorticosterone to aldosterone by CYP11B2 occurs via corticosterone and 18-hydroxycorticosterone as ... via the intermediate 18-hydroxycorticosterone, is only performed by CYP11B2 [42, 43, 44]. Therefore, the absence of detectable ... 18]. We have, therefore, extended our developmental study to examine the effects of maternal smoking on human fetal adrenal ...
Measurement of Peripheral Plasma 18-Oxocortisol Can Discriminate Unilateral Adenoma From Bilateral Diseases in Patients With...
Production of 18-oxo-cortisol in subtypes of primary aldosteronism. Clin Exp Pharmacol Physiol. 1996;23:591-593. ... Serum 18-hydroxycortisol in primary aldosteronism, hypertension, and normotensives. Hypertension. 2001;38(3 pt 2):688-691. ... 18-Hydroxycorticosterone was also reported to help discriminate APA from BHA, especially after posture test.28 However, ... 18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. J Clin Endocrinol ...
The Influence of Sodium Intake on the Pressor Response to Angiotensin II in the Unanaesthetized Rat | Clinical Science |...
Cerilliant - Certified Reference Materials | Certified Reference Standards
Bilateral Hyperplasia of the Adrenal Gland - Renal and Urology News
Anti-C11B2 antibody [EPR10495] Recombinant (ab167413) | Abcam
In CMO-2 deficiency, aldosterone can be low or normal, but at the expense of increased secretion of 18-hydroxycorticosterone. ... Consequently, patients have a greatly increased ratio of 18-hydroxycorticosterone to aldosterone and a low ratio of ... Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18- ... hydroxycorticosterone.. * Involvement in disease. Defects in CYP11B2 are the cause of corticosterone methyloxidase type 1 ...
Metoclopramide Hydrochloride Monograph for Professionals - Drugs.com
Effect of domperidone, an extracerebral inhibitor of dopamine receptors, on thyrotropin, prolactin, renin, aldosterone and 18- ... hydroxycorticosterone in man. J Clin Endocrinol Metab. 1982; 54:869-71. http://www.ncbi.nlm.nih.gov/pubmed/7037817?dopt= ... 18. Hay AM. The mechanism of action of metoclopramide. Gut. 1975; 16:403-4. http://www.ncbi.nlm.nih.gov/pubmed/1140672?dopt= ... 1977; 18:462-7. http://www.ncbi.nlm.nih.gov/pubmed/873328?dopt=AbstractPlus http://www.pubmedcentral.nih.gov/picrender.fcgi? ...
Clinical Trials sub-cluster 33
18 (4): 301-9. PMID 3084123.. *^ Mikosha AS, Pushkarov IS, Chelnakova IS, Remennikov GY (1991). "Potassium Aided Regulation of ... C-18: Estrane). 1. 2-Hydroxyestrone ← Estrone → 16α-Hydroxyestrone → 15α,16α-Hydroxyestrone. 2. 2-Hydroxyestradiol ← Estradiol ... I 18-hydroxylation and 18hydroxy dehydrogenation. II beta-hydroxylation". Acta Endocrin. Copenh. 69: I 701-717, II 718-730.. ... Cortisol also reduces calcium absorption in the intestine. Collagen is an important component of connective tissue. It is ...
Frontiers | Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies | Endocrinology
18. Brdiczka D, Zorov D, Sheu S. Mitochondrial contact sites: their role in energy metabolism and apoptosis. Biochim Biophys ... Translocator Protein, 18 kDa. In the 1970s and 1980s, studies of benzodiazepine drug binding to sites outside of the central ... Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science (2009) 325(5939):490-3 ... Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis. J Biol Chem ...
UPLC-MS/MS Analysis of Aldosterone in Plasma for Clinical Research : Waters
Separation of 18-hydroxycorticosterone is necessary due to the detection of its isotopic transition in the aldosterone-4H2 ... Chromatographic separation was performed on an ACQUITY UPLC I-Class System using a CORTECS UPLC C18 Column followed by ... Figure 2. UPLC separation of aldosterone, aldosterone-4H2, and 18-hydroxycorticosterone using a CORTECS UPLC C18 Column. ... CORTECS UPLC C18, 2.1 x 100 mm, 1.6 μm (Waters p/n 186007095) ...
Etomidate - DrugBank
InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 ... In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have ... Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18- ... hydroxycorticosterone.. Gene Name. CYP11B2. Uniprot ID. P19099. Uniprot Name. Cytochrome P450 11B2, mitochondrial. Molecular ...
Aldosterone - DrugBank
Progestogin-skeleton / 21-hydroxysteroid / 20-oxosteroid / Pregnane-skeleton / 18-oxosteroid / 3-oxo-delta-4-steroid / 3- ... In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have ... 3-oxo steroid, 11beta-hydroxy steroid, 20-oxo steroid, mineralocorticoid, 21-hydroxy steroid, C21-steroid hormone, 18-oxo ... Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18- ...
Congenital Adrenal Hyperplasia
Includes androstenedione, corticosterone, cortisol, cortisone, deoxycorticosterone, 11-deoxycortisol, DHEA, 18- ... hydroxycorticosterone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, pregnenolone, progesterone, and total testosterone.. ... mutation in another 18%, and no mutations in the final 1% of affected individuals. Thus, rare mutation analysis may be needed ...
- Due to the presence of intact 11 beta-hydroxylase 2 (CYP11B2), serum concentrations of all potent mineral corticoids (corticosterone, 18-hydroxycorticosterone , and aldosterone) are typically increased above the normal reference range.13 The final diagnosis is based on genetic testing which is not available in Pakistan. (thefreedictionary.com)
- This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE. (curehunter.com)
- From these two family members, only CYP11B2 can perform the final synthesis step that converts 18-hydroxycorticosterone into aldosterone. (tue.nl)
- A hypothetical binding mode has been proposed for 18-hydroxycorticosterone in CYP11B2, featuring the presence of stabilising hydrogen bonding interactions required for its conversion. (tue.nl)
Corticosterone and 18-hydroxycorticosterone2
- In 17OHD, decreased cortisol secretion causes increased ACTH production, which results in overproduction of 17-deoxysteroids (DOC, corticosterone and 18-hydroxycorticosterone ) by the adrenal cortex. (thefreedictionary.com)
- Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone. (abcam.com)
- Chronically high levels of 18-hydroxycorticosterone are associated with at least three inborn errors of metabolism including adrenal hyperplasia type V, corticosterone methyl oxidase I deficiency, and corticosterone methyl oxidase II deficiency. (hmdb.ca)
- Increases in serum 11-deoxycorticosterone or 18-hydroxycorticosterone suggest presence of an adrenal adenoma or adrenal carcinoma. (renalandurologynews.com)
- Results: Total adrenal volume correlated positively with 18 steroids, most prominently 21-deoxycortisol and four 11-oxygenated-C19 (11oxC19) steroids: 11 -hydroxyandrostenedione (11OHA4), 11-ketoandrostenedione (11ketoA4), 11 -hydroxytestosterone (11OHT), and 11-ketotestosterone (11ketoT) (r ≈ 0.7, P (bireme.br)
- Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronism. (endocrinesciences.com)
- Numerous aldosterone precursors, including deoxycorticosterone and 18-hydroxycorticosterone, have mineralocorticoid activity and may produce or exacerbate features typical of mineralocorticoid hypertension when present in excessive amounts in various pathologic states. (medscape.com)
- Amplification of mineralocorticoid activity of aldosterone by 18-hydroxy-corticosterone and 18-hydroxy-19-nor-corticosterone in adrenalectomized rats. (europills365.com)
- Deoxycorticosterone slightly high and 18-Hydroxycorticosterone high, but 11-deoxycortisol, corticosterone, cortisol all WNL and PRA 1.4 and aldo 27! (nephronpower.com)
- The unique steroids from the ZG are 18-hydroxycorticosterone (180H-B) and aldosterone. (springer.com)
- A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. (curehunter.com)
- With the methanol gradient used, five identified steroids were resolved: progesterone, 11-deoxycorticosterone, corticosterone, 18-hydroxycorticosterone and aldosterone. (bioscientifica.com)
Derivative of corticosterone1
- 18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone. (hmdb.ca)
- 18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa. (wikipedia.org)
- 18-Hydroxycortisol Aldosterone synthase Reddish MJ, Guengerich FP (August 2019). (wikipedia.org)
- The aldosterone synthase enzyme is involved in a series of three chemical reactions that produce aldosterone from other (precursor) molecules: the conversion of 11-deoxycorticosterone to corticosterone, the conversion of corticosterone to 18-hydroxycorticosterone, and the conversion of 18-hydroxycorticosterone to aldosterone. (medlineplus.gov)
- I. Significance of 18-hydroxy-11-deoxycorticosterone, Am. J. Cardiol . (springer.com)
- 11-deoxycorticosterone and 18-hydroxycorticosterone, for example, have significant mineralocorticoid effect. (renalandurologynews.com)
- Plasma deoxycorticosterone, corticosterone, and urinary 18-hydroxycorticosterone levels were increased. (statescale.cf)
- The influences of ACTH, dietary sodium, upright posture and angiotensin II on plasma 18-hydroxy-11-deoxycorticosterone levels in normal subjects. (endocrinesciences.com)
- 11-deoxycorticosterone is converted into Corticosterone which is converted into 18-hydroxy-corticosterone which is oxidized, turning it into the final product, Aldosterone. (wikibooks.org)
- In CMO-1 deficiency, aldosterone is undetectable in plasma, while its immediate precursor, 18-hydroxycorticosterone, is low or normal. (abcam.com)
- also known as aldosterone deficiency due to defect in 18-hydroxylase or aldosterone deficiency I. CMO-1 deficiency is an autosomal recessive disorder of aldosterone biosynthesis. (abcam.com)
- CAH was related to 21-hydroxylase deficiency in 18 patients, and to 3β-Hydroxysteroid dehydrogenase (3βHSD) deficiency in one patient. (biomedcentral.com)
- 17 , 18 Werkmeister and colleagues 15 showed that 25% of patients with classic CAH carried alleles that had CYP-21B gene deletions, despite varied HLA compositions. (glowm.com)
- This is evidenced by the greater numbers of patients having to wait beyond the 18-week target for elective surgery. (biomedcentral.com)
- Such sites have no affinity for dexamethasone, corticosterone, ouabain, amiloride, and 18-hydroxyprogesterone.140,505 Similar receptors for aldosterone were also found in pig kidney, but these had higher values of Kd for desoxycorticosterone acetate and corticosterone. (thesouldynamic.com)
- I have a question if my due date is may 18 2013 and last menstrual was august 11 what day did i conceive? (healthtap.com)