17-Ketosteroids: Steroids that contain a ketone group at position 17.Ketosteroids: Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.17-Hydroxycorticosteroids: A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalAbbreviations as Topic: Shortened forms of written words or phrases used for brevity.Fatty Acids, Essential: Long chain organic acid molecules that must be obtained from the diet. Examples are LINOLEIC ACIDS and LINOLENIC ACIDS.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Steroid Isomerases: Enzymes that catalyze the transposition of double bond(s) in a steroid molecule. EC 5.3.3.Lipid Metabolism: Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.Dioscorea: A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)11-Hydroxycorticosteroids: A group of corticosteroids bearing a hydroxy group at the 11-position.Hydroxycorticosteroids: A group of corticosteroids carrying hydroxy groups, usually in the 11- or 17-positions. They comprise the bulk of the corticosteroids used systemically. As they are relatively insoluble in water, salts of various esterified forms are often used for injections or solutions.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Consumer Health Information: Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.Social Media: Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.Endocrine System Diseases: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.AxisTeaching Materials: Instructional materials used in teaching.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Competitive Behavior: The direct struggle between individuals for environmental necessities or for a common goal.Polycystic Ovary Syndrome: A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.Thyroid Diseases: Pathological processes involving the THYROID GLAND.Pseudomonas putida: A species of gram-negative, aerobic bacteria isolated from soil and water as well as clinical specimens. Occasionally it is an opportunistic pathogen.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Equilenin: An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Gels: Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).Hormone Replacement Therapy: Therapeutic use of hormones to alleviate the effects of hormone deficiency.Dosage Forms: Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Health Personnel: Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Pharmacology: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Attitude of Health Personnel: Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.Adverse Drug Reaction Reporting Systems: Systems developed for collecting reports from government agencies, manufacturers, hospitals, physicians, and other sources on adverse drug reactions.
A patient with preclinical Cushing's syndrome and excessive DHEA-S secretion having unilateral adrenal carcinoma and contralateral adenoma. (1/84)
We report a case of preclinical Cushing's syndrome in a 54-year-old male associated with bilateral adrenocortical tumours. Physical findings and general laboratory data were unremarkable except for mild hypertension (158/90 mmHg) and impaired glucose tolerance. Endocrinological evaluation revealed the presence of autonomous cortisol secretion including unsuppressible serum cortisol by 8 mg dexamethasone test (11 microg/dl), high serum DHEA-S (3580 ng/ml, normal: 400-3500) and increased urinary 17-KS excretion (31.0-35.8 mg/day, normal: 5.8-21.3). CT scan demonstrated the presence of tumours in both adrenals and bilateral adrenalectomy was subsequently performed. Histological examination of the resected specimens revealed an adrenocortical carcinoma on the right side and an adenoma on the left side with noticeable cortical atrophy in non-neoplastic adrenals. Immunohistochemical study of steroidogenic enzymes demonstrated that all the steroidogenic enzymes involved in cortisol biosynthesis were expressed in both right and left adrenal tumours. Enzymatic activities of 21, 17alpha, 18, 11beta-hydroxylases were detected in both right and left adrenals except for the absence of 11beta-hydroxylase activity in the left adrenal adenoma. Results of in vitro tissue steroidogenesis examined in short-term tissue culture of the specimens revealed no significant differences between carcinoma and adenoma in cortisol production, but the production of adrenal androgens in carcinoma was significantly higher than that in adenoma, which may indicate the importance of evaluating adrenal androgen levels in patients with adrenocortical neoplasms. (+info)A case of renin-producing adrenocortical cancer. (2/84)
Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10 cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5 x 8 x 6.5 cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective. (+info)Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation. (3/84)
1 The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (2-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction. (+info)The biochemical study of intermaxillary fixation (IMF) stress in oral surgery inpatients. (4/84)
Although intermaxillary fixation (IMF) is performed to treat the patients with maxillary fracture, this procedure is very stressful to the patients. IMF has been reported to increase noradrenaline (NA) release in the brain and elevate plasma corticosterone contents in the rat. These changes were significantly attenuated by diazepam, an anxiolytic of the benzodiazepine family. These results suggest that IMF could greatly affect the pituitary-adrenal system as a stress. In the present study, in order to examine the influence of IMF on the human body function, we measured levels of 17-hydrocorticosteroids (17-OHCS) and 17-ketosteroid (17-KS), which are metabolites of the adreno-cortical hormone cortisol, in the urine of inpatients undergoing IMF. The subjects were requested to fill out a questionnaire on irritableness caused by IMF. In these patients, urinary 17-OHCS levels were significantly increased after IMF and well correlated to the results of the questionnaire. The finding suggested that urinary 17-OHCS levels reflect stress related to IMF, and that such stress mainly causes an irritated feeling. Natural killer cell activity (NK activity), which is considered to be related to stress, was measured in these patients. The relationship between 17-OHCS levels and NK activity was examined in reference to the results of the questionnaire. Questionnaire showed that most patients noted insomnia and an irritated feeling during IMF. To examine the influence of anxiolytic agents on stress related to IMF, an anxiolytic agent, ethyl loflazepate, was administered during IMF, and urinary 17-OHCS levels were measured. There was no correlation between 17-OHCS levels and NK activity in the patients. Furthermore, no correlation was observed between visual analogue scale (VSA) and NK activity. Increases in 17-OHCS levels in the group treated with ethyl loflazepate, an anxiolytic of the benzodiazepine family, were significantly lower than in the untreated group. This suggests that ethyl loflazepate reduced stress responses to IMF. It has been reported that NK activity is reduced inpatients with depression or chronic fatigue syndrome. However, NK activity may not be affected by mechanical stress such as IMF. The finding that an anxiolytic agent, ethyl loflazepate, inhibited stress responses to IMF further suggests that anxiolytic drugs are very useful for treatment of irritated feeling of the patients undergoing IMF. (+info)Garlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein diet. (5/84)
The effects of garlic supplementation on protein metabolism were investigated by measuring testis testosterone and plasma corticosterone in rats fed diets with different protein levels. In Experiment 1, rats were fed experimental diets with different protein levels (40, 25 or 10 g/100 g casein) with or without 0.8 g/100 g garlic powder. After 28 d of feeding, testosterone contents in the testis were significantly higher and plasma corticosterone concentrations were significantly lower in rats fed 40 and 25% casein diets with garlic powder than in those fed the same diets without garlic powder. Urinary excretion of 17-ketosteroid (an index of testosterone), nitrogen balance and hepatic arginase activity were significantly higher in rats fed the 40% casein diet with garlic powder than in the 40% casein controls. In Experiment 2, the effect of diallyldisulfide (a major volatile sulfur-containing compound in garlic) on the secretion of luteinizing hormone (LH) from the pituitary gland, which regulates testosterone production in the testis, was investigated in anesthetized rats. Plasma LH concentration increased dose dependently after administration of diallyldisulfide (P < 0.01, r = 0.558). These results suggest that dietary supplementation with 0.8 g/100 g garlic alters hormones associated with protein anabolism by increasing testicular testosterone and decreasing plasma corticosterone in rats fed a high protein diet. (+info)Computerized multicuvette system for single substance and group analysis and for the chromatographic isolation and quantitation of compounds in complex mixtures. (6/84)
A new computer-interfaced system of general applicability in the clinical laboratory has been built. The system is constructed around a new type multicuvette. Quantitation is currently by spectrophotometry and is on-line, with use of a mini-computer with output going to an electrostatic printer/plotter. The system can be used for single-substance batch analyses, for group analyses, and for the estimation of profiles of compounds after preliminary high-resolution liquid chromatography tailored to interface with the multicuvette. (+info)Involvement of the cholinergic pathway in the pathogenesis of pituitary Cushing's syndrome. (7/84)
Transsphenoidal adenomectomy is currently the first choice for treatment of patients with pituitary ACTH-dependent Cushing's syndrome. However, pharmacotherapy is prescribed for some patients, e.g., unsuccessful surgery. We treated a woman in whom pituitary Cushing's syndrome was improved while she was on antimuscarinic cholinergic agents, atropine sulphate and pirenzepine hydrochloride. The diminished effect of anticholinergics on ACTH and cortisol was incidentally identified in an inferior petrosal sinus sampling procedure. A single intramuscular injection of atropine significantly decreased both ACTH (43.9 pg/ml to less than 12.0; normal, 12.0-40.0 pg/ml) and cortisol (29.9 microg/dl to 13.6; normal, 7.6-23.6 microg/dl). An M1-muscarinic receptor specific antagonist, pirenzepine hydrochloride, also had a diminishing effect on these hormones and this inhibiting effect was partially blocked by the simultaneous administration of an anticholinesterase agent, pyridostigmine bromide. Chronic oral ingestion of these agents led to improvement in clinical symptoms, and urinary 17-hydroxycorticosteroid and 17-ketosteroid levels were at normal to upper-normal levels. This is the first documentation of involvement of the cholinergic system in the pathogenesis of pituitary Cushing's syndrome. (+info)Micro-analytical identification, by NMR, of elevated steroid in urine of Cushing's syndrome patients. (8/84)
We previously reported that the daily urinary unidentified ketosteroid glucuronide (US-G) level in patients with Cushing's syndrome was much higher than that in the healthy subjects. Furthermore, urine samples from patients with Cushing's syndrome, including those with pituitary adenoma and adrenal adenoma, yielded almost the same high excretion levels, despite the different sites of the adenomas. We extracted US obtained by hydrolysis of US-G in urine of patients with Cushing's syndrome, purified it, and analyzed its chemical structure. Molecular weight and molecular formula were analyzed by MS spectrometry, and the chemical structure was analyzed by NMR spectrometry, utilizing small quantities of refined US. The substance has a molecular weight of 304 Da, a molecular formula of C19H28O3, and its chemical structure is 3alpha,11beta-dihydroxyandrost-4-en-17-one. (+info)... isolated 17-ketosteroids from their own urine; and did blood counts and manometric oxygen consumption measurements on bovine ...
Bagramian ER; Bogdanova EA; Krymskaia ML; Sokovykh SI (1977). "[Diagnostic importance of determining 17-ketosteroids in ...
Gallagher, T. F.; Kritchevsky, Theodore H. (1950). "Perbenzoic Acid Oxidation of 20-Ketosteroids and the Stereochemistry of C- ... 17". J. Am. Chem. Soc. 72 (2): 882-885. doi:10.1021/ja01158a062. Cavarzan, Alessandra; Scarso, Alessandro; Sgarbossa, Paolo; ...
Synthesis of 19-Nor-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone". Journal of the American Chemical Society. 76 ( ... For example, ethynylation of 17-ketosteroids produces important contraceptive medications known as progestins. Examples include ...
17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) is an enzyme that in humans is encoded by the HSD17B3 gene and is involved in ... This isoform of 17β-HSD is expressed predominantly in the testis and catalyzes the conversion of androstenedione to ... Bilbao JR, Loridan L, Audí L, Gonzalo E, Castaño L (September 1998). "A novel missense (R80W) mutation in 17-beta- ... 17β-Hydroxysteroid dehydrogenase GRCh38: Ensembl release 89: ENSG00000130948 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
Similar stereoelectronic effects were observed in studies of the rearrangement of 17-hydroxy-20-ketosteroids. In this case, ...
It is also known as estradiol 17β-undecylate or as estra-1,3,5(10)-triene-3,17β-diol 17β-undecanoate. A few related estradiol ... HALKERSTON ID, HILLMAN J, PALMER D, RUNDLE A (1956). "Changes in the excretion pattern of neutral 17-ketosteroids during ... Leyendecker, G.; Geppert, G.; Nocke, W. & Ufer, J. (1975). "Untersuchungen zur Pharmakokinetik von Östradiol-17β, Östradiol- ... 909-17. PMID 13391788. Bishop, P. M. F. (1958). Endocrine Treatment of Gynaecological Disorders. Modern Trends in Endocrinology ...
1964;34:1401-3. Polish) EXCRETION OF UROPEPSIN AND 17-KETOSTEROIDS IN PATIENTS WITH RESPIRATORY INSUFFICIENCY (Pol Arch Med ...
His later research covered topics including androgen hormones, 17-ketosteroids, antigonadotropins, and methods for ...
1965: "Spectral resolution of low-frequency, small-amplitude rhythms in excreted 17-ketosteroid: probable androgen-induced ...
The steroid core structure is composed of seventeen carbon atoms, bonded in four "fused" rings: three six-member cyclohexane ... is composed of seventeen carbon atoms in carbon-carbon bonds forming four fused rings in a three-dimensional shape. The three ... When the two methyl groups and eight carbon side chains (at C-17, as shown for cholesterol) are present, the steroid is said to ... Microbial catabolism of phytosterol side chains yields C-19 steroids, C-22 steroids, and 17-ketosteroids (i.e. precursors to ...
... and 20-ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans. AKR1A1; AKR1B1; AKR1B10; AKR1C1; AKR1C2; ... 17β-HSDs, and 20α-HSDs, respectively. The AKR1C enzymes act as 3-, 17- ...
... , also known as androst-5-en-3β-ol-17-one, is a naturally occurring androstane steroid and a 17-ketosteroid. It is ... ISBN 978-3-527-30247-5. 3β-Hydroxyandrost-5-en-17-one hydrogen sulfate = (3β)-3-(Sulfooxy)androst-5-en-17-one. R: Sodium salt ( ... Crosbie, D; Black, C; McIntyre, L; Royle, PL; Thomas, S (Oct 17, 2007). Crosbie, David, ed. "Dehydroepiandrosterone for ... androst-4-en-17β-ol-3-one). Prasterone is the 5-dehydro analogue of epiandrosterone (5α-androstan-3β-ol-17-one) and is also ...
Inhibitors of 17β-HSD type II are of interest for the potential treatment of osteoporosis. Some inhibitors of 17β-HSD type I ... Major isoform of 17β-HSD in the granulosa cells of the ovaries. Mutations and associated deficiency have not been reported in ... Wang CT, Li CF, Wu WJ, Huang CN, Li CC, Li WM, Chan TC, Liang PI, Hsing CH, Liao KM (2016). "High Expression of 17β- ... 17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B) (EC 1.1.1.51), also 17-ketosteroid reductases (17-KSR), are a group of ...
Through the measurements of plasma cortisol and urinary 17-ketosteroid levels, the investigators monitored effects on the HPA ...
132 (S1): 17-26. doi:10.1007/s00432-006-0133-5. ISSN 0171-5216. PMID 16845534. Unlike CPA, non-steroidal antiandrogens appear ... 17 (4): 730. doi:10.4103/2230-8210.113770. ISSN 2230-8210. PMID 23961495. Gillatt, David (2006). "Antiandrogen treatments in ... Additional tests that may be considered are markers of testicular, adrenal, or other tumors such as urinary 17-ketosteroid, ...
Thus, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed. Androstenedione is ... Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous ... It is closely related to androstenediol (androst-5-ene-3β,17β-diol). Androstenedione is a precursor of testosterone and other ... Androstenedione, also known as androst-4-ene-3,17-dione, is a naturally occurring androstane steroid and a 17-ketosteroid. It ...
17-diol MeSH D06.472.334.851.968.750 --- androstenediol MeSH D06.472.334.851.968.875 --- androstenedione MeSH D06.472.334.851. ... 17-ketosteroids MeSH D06.472.040.502.112 --- androstenedione MeSH D06.472.040.502.195 --- androsterone MeSH D06.472.040.502.497 ... 17-hydroxycorticosteroids MeSH D06.472.040.585.478.195 --- cortisone MeSH D06.472.040.585.478.225 --- cortodoxone MeSH D06.472. ... 17-alpha-hydroxypregnenolone MeSH D06.472.334.851.687.750 --- progesterone MeSH D06.472.334.851.687.750.074 --- 20-alpha- ...
17-diol MeSH D04.808.054.040.129 --- androsterone MeSH D04.808.054.040.248 --- dihydrotestosterone MeSH D04.808.054.040.248.450 ... betamethasone 17-valerate MeSH D04.808.745.432.769.325 --- desonide MeSH D04.808.745.432.769.344 --- dexamethasone MeSH D04.808 ... betamethasone 17-valerate MeSH D04.808.908.093.250 --- clobetasol MeSH D04.808.908.238 --- dexamethasone MeSH D04.808.908.238. ... 17-ketosteroids MeSH D04.808.578.502.112 --- androstenedione MeSH D04.808.578.502.195 --- androsterone MeSH D04.808.578.502.470 ...
Women with polycystic ovary syndrome tend to have elevated levels of DHEA-S. DHEA, also known as androst-5-en-3β-ol-17-one, is ... DHEA is an uncompetitive inhibitor of G6PDH (Ki = 17 μM; IC50 = 18.7 μM), and is able to lower NADPH levels and reduce NADPH- ... It is closely related structurally to androstenediol (androst-5-ene-3β,17β-diol), androstenedione (androst-4-ene-3,17-dione), ... Ciolino HP, MacDonald CJ, Yeh GC (2002). "Inhibition of carcinogen-activating enzymes by 16alpha-fluoro-5-androsten-17-one". ...
... , also known as 5β-androsterone, as well as 3α-hydroxy-5β-androstan-17-one or etiocholan-3α-ol-17-one, is an ... steroid as well as an endogenous 17-ketosteroid that is produced from the metabolism of testosterone. It causes fever, ...
A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C=O) group. A 17- ... ketosteroid is a ketosteroid in which the ketone is located specifically at the C17 position (in the upper right corner of most ... Hydroxysteroid Hydroxysteroid dehydrogenase 17-Ketosteroids at the US National Library of Medicine Medical Subject Headings ( ... Examples of 17-ketosteroids include: Androstenedione Androstanedione Androsterone Dehydroepiandrosterone Epiandrosterone ...
... (EC 1.14.13.142, KshAB, 3-ketosteroid 9alpha-hydroxylase) is an enzyme with systematic name ... 3-ketosteroid 9alpha-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Capyk, J.K.; Casabon, I.; Gruninger, R.; Strynadka, N.C.; Eltis, L.D. (2011). "Activity of 3-ketosteroid 9α-hydroxylase (KshAB ... Capyk, J.K.; D'Angelo, I.; Strynadka, N.C.; Eltis, L.D. (2009). "Characterization of 3-ketosteroid 9α-hydroxylase, a Rieske ...
... at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... Ketosteroid monooxygenase (EC 1.14.13.54, steroid-ketone monooxygenase, progesterone, NADPH2:oxygen oxidoreductase (20- ... H2O Ketosteroid monooxygenase is a single FAD-containing enzyme that catalyses three types of monooxygenase reaction. Katagiri ... is an enzyme with systematic name ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, ...
"Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3". Chem. Biol. Interact. 191 (1-3): 227-33. ... 17α-Hydroxyprogesterone 16α-Hydroxyprogesterone 5α-Dihydroprogesterone 11-Deoxycorticosterone Beranič N, Gobec S, Rižner TL ( ...
3-keto-steroid reductase Ja 1.1.1.271 GDP-L-fucose synthase Ja ... Deze pagina is voor het laatst bewerkt op 30 mei 2019 om 17:27. ...
17-ketosteroid: …from excessive secretion of androgenic hormones by the adrenal cortex. It is a disorder in which the ...
The reference range of urinary 17-ketosteroids is as follows: Males: 10-20 mg (34-69 µmol)/24 h Females: 5-15 mg (17-52 µmol)/ ... encoded search term (17-Ketosteroids) and 17-Ketosteroids What to Read Next on Medscape. Medscape Consult. ... The 17-ketosteroids are breakdown products of androgens. Examples of 17-ketosteroids include androstenedione, androsterone, ... Newer tests have superseded 17-ketosteroid testing, and the assay is seldom used now. ...
17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other ... 17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other ...
What is 17-ketosteroids? Meaning of 17-ketosteroids medical term. What does 17-ketosteroids mean? ... Looking for online definition of 17-ketosteroids in the Medical Dictionary? 17-ketosteroids explanation free. ... 17-ketosteroids. Also found in: Acronyms. 17-ke·to·ste·roids (17-KS), (kētō-stēroydz), Nominally, any steroid with a carbonyl ... 17-ke·to·ste·roids (kētō-steroydz) Any steroids with a ketone group on C-17; commonly used to designate urinary metabolites ...
Estrogen and 17-Ketosteroid Excretion in Patients with Breast Carcinoma. Howard C. Taylor Jr., Flora E. Mecke and Gray H. ... Estrogen and 17-Ketosteroid Excretion in Patients with Breast Carcinoma. Howard C. Taylor Jr., Flora E. Mecke and Gray H. ... Estrogen and 17-Ketosteroid Excretion in Patients with Breast Carcinoma. Howard C. Taylor Jr., Flora E. Mecke and Gray H. ... Estrogen and 17-Ketosteroid Excretion in Patients with Breast Carcinoma Message Subject (Your Name) has forwarded a page to you ...
Friedlander on 17 ketosteroids w creat 24hr urine: An increase in urine 17-ketosteroid indicates you have higher-than-usual ... Irreg menses: High ketosteroids may indicate an adrenal malfunction. Such can inhibit regular ovulation, and hence cause ... 17 If normethanephrine free 181pg/ml & metanephrine free 232 pg/ml 24hr urine collection, will my sisters matanephrine ... Ive got normalization of prostatic fluid and an increase in 17-ketosteroids in urine. What does this mean? ...
Looking for online definition of 17-ketosteroids or what 17-ketosteroids stands for? 17-ketosteroids is listed in the Worlds ... 17-KS. (redirected from 17-ketosteroids). Also found in: Medical. Acronym. Definition. ... The 2 most commonly used assays measure urinary excretion of PT, a urinary metabolite of 17OHP, or 17-ketosteroids (17-KS), a ... Test tube extraction method for the microdetermination of urinary 17-ketosteroids.. Clinical Chemistry through Clinical ...
Decreased conversion of androgens to normal 17-ketosteroid metabolites: a nonspecific consequence of illness. by Barnett ... Decreased conversion of androgens to normal 17-ketosteroid metabolites: a nonspecific consequence of illness.. @article{ ... Decreased conversion of androgens to normal 17-ketosteroid metabolites: a nonspecific consequence of illness.}, author={Barnett ...
21-dihydroxy-20-ketosteroids. The androgens in female are produced by the adrenal cortex and in small amounts by the ovary; in ... 21-dihydroxy-20-ketosteroids (DKS), male adrenals, as well as possible androgen secretion by the ovary, the significance of ... 21-dihydroxy-20-ketosteroids determinations in urine are of considerable importance when measured regularly for long periods of ... Measurement of the urinary neutral 17-ketosteroids is becoming more frequently used as an index of androgenic activity but it ...
Ketosteroids (Urine) Test - View Normal Values, Test Results, Procedure to conduct & Best Prices for 17 - Ketosteroids (Urine) ... Ketosteroids (Urine) Test This is a 24 hour urine test. The urine will be collected from the patient over a span of 24 hours. ... Ketosteroids (Urine) Test No specific preparation is necessary. Let the doctor know of any medicines being taken by the patient ... Ketosteroids (Urine) Test? Most actions in the body are facilitated by hormones circulating in the blood. These hormones are ...
What is 17-ketosteroid? Meaning of 17-ketosteroid medical term. What does 17-ketosteroid mean? ... Looking for online definition of 17-ketosteroid in the Medical Dictionary? 17-ketosteroid explanation free. ... any of the adrenal cortical hormones, or ketosteroids, that has a ketone group attached to its seventeenth carbon atom. These ... 17-ketosteroid. (ke-to-steroyd) One of a group of neutral steroids having a ketone group in carbon position 17. They are ...
Chemical method for the determination of 17-hydroxycorticosteroids and 17-ketosteroids in urine following hydrolysis with beta- ... Chemical method for the determination of 17-hydroxycorticosteroids and 17-ketosteroids in urine following hydrolysis with beta- ... A procedure for the measurement of urinary 17-hydroxycorticosteroids, aldosterone acid-labile conjugate, and free plasma ... article{Glenn1953ChemicalMF, title={Chemical method for the determination of 17-hydroxycorticosteroids and 17-ketosteroids in ...
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17-Ketosteroids, urine (17-KS), are breakdown products of androgens and are an adrenal function test. Examples of 17-KS include ...
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Definition17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and ... 17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other ...
17-Ketosteroids. The 17-Ketosteroids are the sex steroids and are mainly produced in the zona reticularis layer (the innermost ...
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Introduction. Following is a breakdown of 510(k) exempt and Good Manufacturing Practice (GMP)/Quality System exemptions listed by device class. All devices in this list are 510(k) exempt unless further qualified by a footnote. Only devices annotated by (*) are also exempt from GMP except for general recordkeeping requirements and compliant files.. Class I Devices. FDA has exempted almost all class I devices (with the exception of Reserved Devices from the premarket notification requirement, including those devices that were exempted by final regulation published in the Federal Registers of December 7, 1994, and January 16, 1996. Some 510(k) exemptions annotated with \#\ are with certain limitations as noted in the footnotes. It is important to confirm the exempt status and any limitations that apply with 21 CFR Parts 862-892. Limitations of device exemptions are covered under 21 CFR xxx.9, where xxx refers to Parts 862-892.. If a manufacturers device falls into a generic category of exempted ...
4-ANDROSTENE-3-17-DIONE. Identifiers. (8R,9S,10R,13S,14S)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a] ... 4-ANDROSTENE-3-17-DIONE. ASD as a free ligand exists in 23 entries. Examples include: 2VCV 1XF0 4AT2 ... 4-Androstene-3,17-dione. Mechanism of action. 4-androstenedione is a 19-carbon steroid hormone produced in the adrenal glands ... InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-, ...
17-Ketosteroids urine test. 17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called ... 17-OH progesterone. 17-OH progesterone is a blood test that measures the amount of 17-OH progesterone. This is a hormone ... 17-hydroxycorticosteroid urine test. The 17-hydroxycorticosteroid test measures the level of 17-OHCS in the urine. ...
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- The 17-ketosteroids are breakdown products of androgens. (medscape.com)
- 17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other hormones released by the adrenal glands in males and females, and by the testes in males. (medlineplus.gov)
- The 2 most commonly used assays measure urinary excretion of PT, a urinary metabolite of 17OHP, or 17-ketosteroids (17-KS), a urinary metabolite of androgens. (thefreedictionary.com)
- Decreased conversion of androgens to normal 17-ketosteroid metabolites: a nonspecific consequence of illness. (semanticscholar.org)
- 17-Ketosteroids, urine (17-KS), are breakdown products of androgens and are an adrenal function test. (5minuteconsult.com)
- In their active form, androgens have a 17-beta-hydroxy group. (drugs.com)
- Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. (nih.gov)
- Affected men have decreased serum testosterone concentrations, with urinary excretion of 17-ketosteroids (components of certain male hormones, or androgens ) in the normal or low-normal range. (britannica.com)
- Decreased level of serum cortisol, raised 17-hydroxy progesterone, raised ACTH and raised urinary 17-ketosteroids levels confirmed the diagnosis. (thefreedictionary.com)
- 17-OH progesterone is a blood test that measures the amount of 17-OH progesterone. (scripps.org)
- Cortisol , the major glucocorticoid, is produced when progesterone is hydroxylated at three positions, C-11, C-17 and C21. (citizendium.org)
- Also, curcumin increased the level of 17-ketosteroid reductase enzyme and subsequently increased the testosterone level in cadmium induced testicular damage and in gallic acid induced testicular toxicity . (thefreedictionary.com)
- Familial male pseudohermaphroditism with gynecomastia due to a testicular 17-ketosteroid reductase defect. (thefreedictionary.com)
- Individuals with 5α-reductase-2 deficiency (5α-RD-2) and 17β-hydroxysteroid dehydrogenase-3 deficiency (17β-HSD-3) are often raised as girls. (springer.com)
- Male pseudohermaphroditism with gynaecomastia due to testicular 17-ketosteroid reductase deficiency. (springer.com)
- 6 Other reports relate to subjects with 5α-reductase deficiency 7 , 8 and 17β-hydroxysteroid dehydrogenase deficiency. (aappublications.org)
- 17-beta hydroxysteroid dehydrogenase 3 deficiency is a condition that affects male sexual development. (medlineplus.gov)
- Most people with 17-beta hydroxysteroid dehydrogenase 3 deficiency are born with external genitalia that appear female. (medlineplus.gov)
- Children with 17-beta hydroxysteroid dehydrogenase 3 deficiency are often raised as girls. (medlineplus.gov)
- 17-beta hydroxysteroid dehydrogenase 3 deficiency is a rare disorder. (medlineplus.gov)
- Mutations in the HSD17B3 gene cause 17-beta hydroxysteroid dehydrogenase 3 deficiency. (medlineplus.gov)
- in the male fetus, resulting in the abnormalities in the external sex organs that occur in 17-beta hydroxysteroid dehydrogenase 3 deficiency. (medlineplus.gov)
- and have two copies of a mutated gene in each cell are affected by 17-beta hydroxysteroid dehydrogenase 3 deficiency. (medlineplus.gov)
- 1996). Molecular genetics and pathophysiology of 17 β-hydroxysteroid dehydrogenase 3 deficiency. (springer.com)
- It can regulate the activity of the epithelium of the seminal vesicles‚ the activity of the prostate‚ and the activity of spermatogenesis for people who have a ketosteroid deficiency. (pureformulas.com)
- Examples of 17-ketosteroids include: Androstenedione Androstanedione Androsterone Dehydroepiandrosterone Epiandrosterone Epietiocholanolone Etiocholanolone 17-Ketosteroids are endogenous steroid hormones. (wikipedia.org)
- Increase of 17-Ketosteroids may indicate: Cushing's Syndrome, Poly Cystic Ovary Syndrome, Ovarian Cancer, Testicular Cancer. (lybrate.com)
- The primary pathway involves conversion of 17α-hydroxypregnenolone to DHEA by way of 17,20-lyase, with subsequent conversion of DHEA to androstenedione via the enzyme 3β-hydroxysteroid dehydrogenase. (wikipedia.org)
- The secondary pathway involves conversion of 17α-hydroxyprogesterone, most often a precursor to cortisol, to androstenedione directly by way of 17,20-lyase. (wikipedia.org)
- Thus, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed. (wikipedia.org)
- Levels of 17-ketosteroids increase 50% to 100% after an injection of ACTH. (thefreedictionary.com)
- As measured by peripheral eosinophil response to ACTH administration, urinary 17-hydroxycorticoid excretion and general observation of well-being and morbidity, no effect of pure p,p'-DDD at 80-200 mg/kg body-weight/day for up to 60 days was seen, while the technical product and fractions identified as containing o,p'-DDD were strongly active. (inchem.org)
- Three sulphate esters of 17-ketosteroids in the plasma of normal subjects and after administration of ACTH. (springer.com)
- Along with the blood tests, you may also have a urine cortisol test or urine 17-ketosteroids test , which involves collecting the urine over a 24-hour period . (adam.com)
- Along with the blood tests, sometimes a urinary free cortisol test or urinary 17-ketosteroids may also be measured. (uclahealth.org)
- One measure of corticosteroids activity is the determination of urinary 17, 21-dihydroxy-20-ketosteroids. (usu.edu)
- The HSD17B3 gene provides instructions for making an enzyme called 17-beta hydroxysteroid dehydrogenase 3. (medlineplus.gov)
- The purpose of this study is to determine the changes in concentrations of neutral 17-ketosteroid and 17,21-dihydoxy-20-ketosteroid hormones in women's urine during specified days of the menstrual period, which would help to define the effect of ovulation on the urinary excretion of these hormones. (usu.edu)
- Specific abnormal endocrine function tests include low urinary excretion of pituitary gonadotropin and 17-ketosteroids. (annals.org)
- Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically urine) to determine 17-ketosteroid sulfate (17-KS-S), a metabolite of dehydroepiandrosterone (DHEA)-sulfate. (medicalproductguide.com)
- When these hormones are broken down, they produce molecules called 17- Ketosteroids which are present in the urine. (lybrate.com)
- any of the adrenal cortical hormones, or ketosteroids, that has a ketone group attached to its seventeenth carbon atom. (thefreedictionary.com)
- A procedure for the measurement of urinary 17-hydroxycorticosteroids, aldosterone acid-labile conjugate, and free plasma cortisol in patients with chronic illness. (semanticscholar.org)
- Laboratory findings include elevated serum and urinary 17-ketosteroids as well as estrogens. (health.am)
- Hammond GL, 1995) whereas C19 17-ketosteroids such as dehydroepiandrosterone (DHEA) and androstendione do not bind so easily. (cdc.gov)
- Ben Rhouma B, Kallabi F, Mahfoudh N, Ben Mahmoud A, Engeli RT, Kamoun H, Keskes L, Odermatt A, Belguith N. Novel cases of Tunisian patients with mutations in the gene encoding 17β-hydroxysteroid dehydrogenase type 3 and a founder effect. (medlineplus.gov)
- To identify associations between 17β-hydroxysteroid dehydrogenase type 2 (HSD17B2) expression and clinicopathological variables and prognoses in patients with urothelial carcinoma of the urinary tract. (jcancer.org)
- 17β-hydroxysteroid dehydrogenase type 2, Urothelial carcinoma, Prognosis. (jcancer.org)
- In addition, serum DHEA and 24-hour urine 17-ketosteroids levels were done in virilising adrenal lesions. (thefreedictionary.com)
- Bryson RW, Martin DF (1954) 17-Ketosteroid excretion in a case of manic-depressive psychosis. (springer.com)
- Measurement of the urinary neutral 17-ketosteroids is becoming more frequently used as an index of androgenic activity but it should be borne in mind that the androgenic ptency of a given urine extract will not necessarily parallel 17-ketosteroid concentration. (usu.edu)
- Until more is known about androgen and 17,21-dihydroxy-20-ketosteroids (DKS), male adrenals, as well as possible androgen secretion by the ovary, the significance of normal neutral 17-ketosteroids and 17,21-dihydroxy-20-ketosteroids determinations in urine are of considerable importance when measured regularly for long periods of time. (usu.edu)
- Yu (1964) found that neutral 17-ketosteroids gradually increased from the 9 to 15 days. (usu.edu)
- The oxidation of the C-17 carbon must occur before the hydroxylation at C-21 to synthesize cortisol, otherwise corticosterone is formed. (citizendium.org)
- A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C=O) group. (wikipedia.org)
- I have very high levels of 17 ketosteroids, as a woman. (healthtap.com)
- The urine sample is analyzed for an increase or decrease in 17- Ketosteroid levels. (lybrate.com)
- Clinical staging is similar to that for germ cell tumors, and levels of the 17-ketosteroids can be helpful in distinguishing between benign and malignant lesions. (health.am)
- Chemical method for the determination of 17-hydroxycorticosteroids and 17-ketosteroids in urine following hydrolysis with beta-glucuronidase. (semanticscholar.org)
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- CHI also includes 17-OH-pregnenolone, an important precursor steroid, along with clinically relevant estrogen ratios that provide insights into breast cancer risk and estrogen metabolism. (rmalab.com)
- Base-line urinary 17-hydroxysteroids are usually normal, but pituitary adrenocorticotrophic hormone reserve assessed by metyrapone tests is decreased. (annals.org)