Steroids that contain a ketone group at position 17.
Steroid derivatives formed by oxidation of a methyl group on the side chain or a methylene group in the ring skeleton to form a ketone.
A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

A patient with preclinical Cushing's syndrome and excessive DHEA-S secretion having unilateral adrenal carcinoma and contralateral adenoma. (1/84)

We report a case of preclinical Cushing's syndrome in a 54-year-old male associated with bilateral adrenocortical tumours. Physical findings and general laboratory data were unremarkable except for mild hypertension (158/90 mmHg) and impaired glucose tolerance. Endocrinological evaluation revealed the presence of autonomous cortisol secretion including unsuppressible serum cortisol by 8 mg dexamethasone test (11 microg/dl), high serum DHEA-S (3580 ng/ml, normal: 400-3500) and increased urinary 17-KS excretion (31.0-35.8 mg/day, normal: 5.8-21.3). CT scan demonstrated the presence of tumours in both adrenals and bilateral adrenalectomy was subsequently performed. Histological examination of the resected specimens revealed an adrenocortical carcinoma on the right side and an adenoma on the left side with noticeable cortical atrophy in non-neoplastic adrenals. Immunohistochemical study of steroidogenic enzymes demonstrated that all the steroidogenic enzymes involved in cortisol biosynthesis were expressed in both right and left adrenal tumours. Enzymatic activities of 21, 17alpha, 18, 11beta-hydroxylases were detected in both right and left adrenals except for the absence of 11beta-hydroxylase activity in the left adrenal adenoma. Results of in vitro tissue steroidogenesis examined in short-term tissue culture of the specimens revealed no significant differences between carcinoma and adenoma in cortisol production, but the production of adrenal androgens in carcinoma was significantly higher than that in adenoma, which may indicate the importance of evaluating adrenal androgen levels in patients with adrenocortical neoplasms.  (+info)

A case of renin-producing adrenocortical cancer. (2/84)

Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10 cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5 x 8 x 6.5 cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective.  (+info)

Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation. (3/84)

1 The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (2-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction.  (+info)

The biochemical study of intermaxillary fixation (IMF) stress in oral surgery inpatients. (4/84)

Although intermaxillary fixation (IMF) is performed to treat the patients with maxillary fracture, this procedure is very stressful to the patients. IMF has been reported to increase noradrenaline (NA) release in the brain and elevate plasma corticosterone contents in the rat. These changes were significantly attenuated by diazepam, an anxiolytic of the benzodiazepine family. These results suggest that IMF could greatly affect the pituitary-adrenal system as a stress. In the present study, in order to examine the influence of IMF on the human body function, we measured levels of 17-hydrocorticosteroids (17-OHCS) and 17-ketosteroid (17-KS), which are metabolites of the adreno-cortical hormone cortisol, in the urine of inpatients undergoing IMF. The subjects were requested to fill out a questionnaire on irritableness caused by IMF. In these patients, urinary 17-OHCS levels were significantly increased after IMF and well correlated to the results of the questionnaire. The finding suggested that urinary 17-OHCS levels reflect stress related to IMF, and that such stress mainly causes an irritated feeling. Natural killer cell activity (NK activity), which is considered to be related to stress, was measured in these patients. The relationship between 17-OHCS levels and NK activity was examined in reference to the results of the questionnaire. Questionnaire showed that most patients noted insomnia and an irritated feeling during IMF. To examine the influence of anxiolytic agents on stress related to IMF, an anxiolytic agent, ethyl loflazepate, was administered during IMF, and urinary 17-OHCS levels were measured. There was no correlation between 17-OHCS levels and NK activity in the patients. Furthermore, no correlation was observed between visual analogue scale (VSA) and NK activity. Increases in 17-OHCS levels in the group treated with ethyl loflazepate, an anxiolytic of the benzodiazepine family, were significantly lower than in the untreated group. This suggests that ethyl loflazepate reduced stress responses to IMF. It has been reported that NK activity is reduced inpatients with depression or chronic fatigue syndrome. However, NK activity may not be affected by mechanical stress such as IMF. The finding that an anxiolytic agent, ethyl loflazepate, inhibited stress responses to IMF further suggests that anxiolytic drugs are very useful for treatment of irritated feeling of the patients undergoing IMF.  (+info)

Garlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein diet. (5/84)

The effects of garlic supplementation on protein metabolism were investigated by measuring testis testosterone and plasma corticosterone in rats fed diets with different protein levels. In Experiment 1, rats were fed experimental diets with different protein levels (40, 25 or 10 g/100 g casein) with or without 0.8 g/100 g garlic powder. After 28 d of feeding, testosterone contents in the testis were significantly higher and plasma corticosterone concentrations were significantly lower in rats fed 40 and 25% casein diets with garlic powder than in those fed the same diets without garlic powder. Urinary excretion of 17-ketosteroid (an index of testosterone), nitrogen balance and hepatic arginase activity were significantly higher in rats fed the 40% casein diet with garlic powder than in the 40% casein controls. In Experiment 2, the effect of diallyldisulfide (a major volatile sulfur-containing compound in garlic) on the secretion of luteinizing hormone (LH) from the pituitary gland, which regulates testosterone production in the testis, was investigated in anesthetized rats. Plasma LH concentration increased dose dependently after administration of diallyldisulfide (P < 0.01, r = 0.558). These results suggest that dietary supplementation with 0.8 g/100 g garlic alters hormones associated with protein anabolism by increasing testicular testosterone and decreasing plasma corticosterone in rats fed a high protein diet.  (+info)

Computerized multicuvette system for single substance and group analysis and for the chromatographic isolation and quantitation of compounds in complex mixtures. (6/84)

A new computer-interfaced system of general applicability in the clinical laboratory has been built. The system is constructed around a new type multicuvette. Quantitation is currently by spectrophotometry and is on-line, with use of a mini-computer with output going to an electrostatic printer/plotter. The system can be used for single-substance batch analyses, for group analyses, and for the estimation of profiles of compounds after preliminary high-resolution liquid chromatography tailored to interface with the multicuvette.  (+info)

Involvement of the cholinergic pathway in the pathogenesis of pituitary Cushing's syndrome. (7/84)

Transsphenoidal adenomectomy is currently the first choice for treatment of patients with pituitary ACTH-dependent Cushing's syndrome. However, pharmacotherapy is prescribed for some patients, e.g., unsuccessful surgery. We treated a woman in whom pituitary Cushing's syndrome was improved while she was on antimuscarinic cholinergic agents, atropine sulphate and pirenzepine hydrochloride. The diminished effect of anticholinergics on ACTH and cortisol was incidentally identified in an inferior petrosal sinus sampling procedure. A single intramuscular injection of atropine significantly decreased both ACTH (43.9 pg/ml to less than 12.0; normal, 12.0-40.0 pg/ml) and cortisol (29.9 microg/dl to 13.6; normal, 7.6-23.6 microg/dl). An M1-muscarinic receptor specific antagonist, pirenzepine hydrochloride, also had a diminishing effect on these hormones and this inhibiting effect was partially blocked by the simultaneous administration of an anticholinesterase agent, pyridostigmine bromide. Chronic oral ingestion of these agents led to improvement in clinical symptoms, and urinary 17-hydroxycorticosteroid and 17-ketosteroid levels were at normal to upper-normal levels. This is the first documentation of involvement of the cholinergic system in the pathogenesis of pituitary Cushing's syndrome.  (+info)

Micro-analytical identification, by NMR, of elevated steroid in urine of Cushing's syndrome patients. (8/84)

We previously reported that the daily urinary unidentified ketosteroid glucuronide (US-G) level in patients with Cushing's syndrome was much higher than that in the healthy subjects. Furthermore, urine samples from patients with Cushing's syndrome, including those with pituitary adenoma and adrenal adenoma, yielded almost the same high excretion levels, despite the different sites of the adenomas. We extracted US obtained by hydrolysis of US-G in urine of patients with Cushing's syndrome, purified it, and analyzed its chemical structure. Molecular weight and molecular formula were analyzed by MS spectrometry, and the chemical structure was analyzed by NMR spectrometry, utilizing small quantities of refined US. The substance has a molecular weight of 304 Da, a molecular formula of C19H28O3, and its chemical structure is 3alpha,11beta-dihydroxyandrost-4-en-17-one.  (+info)

17-Ketosteroids are a group of steroid compounds that contain a ketone group at the 17th carbon position in their molecular structure. They are produced as metabolic byproducts of certain hormones, such as androgens and estrogens, in the human body.

The term "17-KS" or "17-ketosteroids" is often used to refer to a class of urinary steroid metabolites that can be measured in the urine to assess adrenal and gonadal function. The measurement of 17-KS is particularly useful in monitoring patients with certain endocrine disorders, such as congenital adrenal hyperplasia or adrenal tumors.

The two major 17-KS that are routinely measured in urine are androsterone and etiocholanolone, which are derived from the metabolism of testosterone and dehydroepiandrosterone (DHEA), respectively. Other 17-KS include tetrahydrocortisone, tetrahydrocortisol, and 5-androstene-3β,17β-diol.

It's worth noting that the measurement of 17-KS has largely been replaced by more specific tests, such as the measurement of individual steroid hormones or their metabolites using mass spectrometry-based methods.

Ketosteroids are a type of steroid compound that contain a ketone functional group in their chemical structure. They are derived from cholesterol and are present in both animal and plant tissues. Some ketosteroids are produced endogenously, while others can be introduced exogenously through the diet or medication.

Endogenous ketosteroids include steroid hormones such as testosterone, estradiol, and cortisol, which contain a ketone group in their structure. Exogenous ketosteroids can be found in certain medications, such as those used to treat hormonal imbalances or inflammation.

Ketosteroids have been studied for their potential therapeutic uses, including as anti-inflammatory agents and for the treatment of hormone-related disorders. However, more research is needed to fully understand their mechanisms of action and potential benefits.

17-Hydroxycorticosteroids are a class of steroid hormones that are produced in the adrenal gland. They are formed from the metabolism of cortisol, which is a hormone that helps regulate metabolism, immune response, and stress response. 17-Hydroxycorticosteroids include compounds such as cortisone and corticosterone.

These hormones have various functions in the body, including:

* Regulation of carbohydrate, fat, and protein metabolism
* Suppression of the immune system
* Modulation of the stress response
* Influence on blood pressure and electrolyte balance

Abnormal levels of 17-hydroxycorticosteroids can indicate problems with the adrenal gland or pituitary gland, which regulates adrenal function. They are often measured in urine or blood tests to help diagnose conditions such as Cushing's syndrome (overproduction of cortisol) and Addison's disease (underproduction of cortisol).

3-Hydroxysteroid dehydrogenases (3-HSDs) are a group of enzymes that play a crucial role in steroid hormone biosynthesis. These enzymes catalyze the conversion of 3-beta-hydroxy steroids to 3-keto steroids, which is an essential step in the production of various steroid hormones, including progesterone, cortisol, aldosterone, and sex hormones such as testosterone and estradiol.

There are several isoforms of 3-HSDs that are expressed in different tissues and have distinct substrate specificities. For instance, 3-HSD type I is primarily found in the ovary and adrenal gland, where it catalyzes the conversion of pregnenolone to progesterone and 17-hydroxyprogesterone to 17-hydroxycortisol. On the other hand, 3-HSD type II is mainly expressed in the testes, adrenal gland, and placenta, where it catalyzes the conversion of dehydroepiandrosterone (DHEA) to androstenedione and androstenedione to testosterone.

Defects in 3-HSDs can lead to various genetic disorders that affect steroid hormone production and metabolism, resulting in a range of clinical manifestations such as adrenal insufficiency, ambiguous genitalia, and sexual development disorders.

Substrate specificity in the context of medical biochemistry and enzymology refers to the ability of an enzyme to selectively bind and catalyze a chemical reaction with a particular substrate (or a group of similar substrates) while discriminating against other molecules that are not substrates. This specificity arises from the three-dimensional structure of the enzyme, which has evolved to match the shape, charge distribution, and functional groups of its physiological substrate(s).

Substrate specificity is a fundamental property of enzymes that enables them to carry out highly selective chemical transformations in the complex cellular environment. The active site of an enzyme, where the catalysis takes place, has a unique conformation that complements the shape and charge distribution of its substrate(s). This ensures efficient recognition, binding, and conversion of the substrate into the desired product while minimizing unwanted side reactions with other molecules.

Substrate specificity can be categorized as:

1. Absolute specificity: An enzyme that can only act on a single substrate or a very narrow group of structurally related substrates, showing no activity towards any other molecule.
2. Group specificity: An enzyme that prefers to act on a particular functional group or class of compounds but can still accommodate minor structural variations within the substrate.
3. Broad or promiscuous specificity: An enzyme that can act on a wide range of structurally diverse substrates, albeit with varying catalytic efficiencies.

Understanding substrate specificity is crucial for elucidating enzymatic mechanisms, designing drugs that target specific enzymes or pathways, and developing biotechnological applications that rely on the controlled manipulation of enzyme activities.

A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C=O) group. A 17- ... ketosteroid is a ketosteroid in which the ketone is located specifically at the C17 position (in the upper right corner of most ... Hydroxysteroid Hydroxysteroid dehydrogenase 17-Ketosteroids at the U.S. National Library of Medicine Medical Subject Headings ( ... Examples of 17-ketosteroids include: Androstenedione Androstanedione Androsterone Dehydroepiandrosterone Epiandrosterone ...
doi:10.1530/ERC-17-0153. PMID 28667081. Odlind V, Milsom I, Persson I, Victor A (June 2002). "Can changes in sex hormone ... 17 (3): 284-95. doi:10.1007/s11102-013-0504-2. PMID 23925896. S2CID 30697394. Shimon I, Barkan A (December 2012). "Estrogen ... 17 (Suppl 2): 34-7. doi:10.3109/13697137.2014.956717. PMID 25223916. S2CID 5084606. Bińkowska M (October 2014). "Menopausal ... 753-. ISBN 978-1-4511-4847-3. Stanczyk FZ, Archer DF, Bhavnani BR (2013). "Ethinyl estradiol and 17β-estradiol in combined oral ...
Bagramian ER, Bogdanova EA, Krymskaia ML, Sokovykh SI (February 1977). "[Diagnostic importance of determining 17-ketosteroids ...
The earliest PubChem patent record for 16-DPA is US2656364A of 1951, describing its conversion into 17-ketosteroids. Mexican ... Hershberg, Emanuel B.; Oliveto, Eugene P. (20 October 1953). "Process for the manufacture of 17-keto steroids". Ramakrishna, ... 17-keto backbone): testosterone* and esters, various synthetic derivatives; Estrogens (mainly of a C18 estrane, 17-hydroxy ...
17 (2): 239-59. doi:10.1517/14728214.2012.683411. PMID 22612692. S2CID 22068249. Lemke TL, Williams DA (24 January 2012). ... 455-. ISBN 978-0-08-053620-0. Hamburger C, Renaud B, Buda M, Lewis BD, Pujol JF (August 1958). "Testosterone treatment and 17- ... ketosteroid excretion. V. Administration of testosterone per rectum". Acta Endocrinol. 28 (4): 529-36. doi:10.1530/acta. ... Hamburger, Christian (1952). "17-Ketosteroid Excretion and Modes of Administering Testosterone Preparations". Ciba Foundation ...
List of androgen esters § Testosterone esters Hamburger C (August 1956). "Testosterone treatment and 17-ketosteroid excretion. ...
Gallagher, T. F.; Kritchevsky, Theodore H. (1950). "Perbenzoic Acid Oxidation of 20-Ketosteroids and the Stereochemistry of C- ... 8 (20): 4708-17. doi:10.1002/1521-3765(20021018)8:20. 3.0.CO;2-U. ISSN 1521-3765. PMID 12561111. Leisch, Hannes; Morley, Krista ... 17". J. Am. Chem. Soc. 72 (2): 882-885. doi:10.1021/ja01158a062. Cavarzan, Alessandra; Scarso, Alessandro; Sgarbossa, Paolo; ...
17 (5): 399-408. doi:10.1038/sj.ijir.3901334. PMID 15889125. Becker KL (2001). Principles and Practice of Endocrinology and ... Testosterone propionate, or testosterone 17β-propanoate, is a synthetic androstane steroid and a derivative of testosterone. It ... 247-. ISBN 978-1-60795-008-0. Hamburger C (1952). "17-Ketosteroid Excretion and Modes of Administering Testosterone ...
Synthesis of 19-Nor-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone". Journal of the American Chemical Society. 76 ( ... For example, ethynylation of 17-ketosteroids produces important contraceptive medications known as progestins. Examples include ...
... is composed of seventeen carbon atoms in carbon-carbon bonds forming four fused rings in a three-dimensional shape. The three ... 11-oxo steroids rather than 11-keto steroids), because "keto" includes the carbon that is part of the steroid nucleus and the ... It is typically composed of seventeen carbon atoms, bonded in four fused rings: three six-member cyclohexane rings (rings A, B ... The term '17-keto steroids', often used in the medical literature, is incorrect because C-17 is specified twice, as the term ...
17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) is an enzyme that in humans is encoded by the HSD17B3 gene and is involved in ... This isoform of 17β-HSD is expressed predominantly in the testis and catalyzes the conversion of androstenedione to ... Retrieved 2017-03-17. Ademola Akesode F, Meyer WJ, Migeon CJ (December 1977). "Male pseudohermaphroditism with gynaecomastia ... Bilbao JR, Loridan L, Audí L, Gonzalo E, Castaño L (September 1998). "A novel missense (R80W) mutation in 17-beta- ...
Similar stereoelectronic effects were observed in studies of the rearrangement of 17-hydroxy-20-ketosteroids. In this case, ...
doi:10.1530/ERC-17-0153. PMID 28667081. Langley RE, Cafferty FH, Alhasso AA, Rosen SD, Sundaram SK, Freeman SC, et al. (April ... Estradiol 17β, estrone, FSH and LH were measured in serum by radioimmunoassay before and after application of the hormone and ... "17-undecenoate of estradiol". Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (1967). "Transcriptional ... The compound is also known as estradiol 17β-undecylate or as estra-1,3,5(10)-triene-3,17β-diol 17β-undecanoate. The undecylic ...
1964;34:1401-3. Polish) EXCRETION OF UROPEPSIN AND 17-KETOSTEROIDS IN PATIENTS WITH RESPIRATORY INSUFFICIENCY (Pol Arch Med ...
His later research covered topics including androgen hormones, 17-ketosteroids, antigonadotropins, and methods for ...
Human 17β-HSD1 was the first enzyme of the 17β-HSD family to be cloned and to have its sequence identified. Its three- ... 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes ... Lin SX, Yang F, Jin JZ, Breton R, Zhu DW, Luu-The V, Labrie F (Aug 1992). "Subunit identity of the dimeric 17 beta- ... Furthermore 17β-HSD1 levels positively correlate with estradiol and negatively correlate with DHT levels in breast cancer cells ...
doi:10.1016/S0022-5347(17)63760-1. PMID 14260883. Marmorston, Jessie; Crowley, Lawrence G.; Myers, Sara M.; Stern, Elizabeth; ... Hopkins, Carl E. (June 1965). "I. Urinary excretion of neutral 17-ketosteroids and pregnanediol by patients with breast cancer ...
1965: "Spectral resolution of low-frequency, small-amplitude rhythms in excreted 17-ketosteroid: probable androgen-induced ...
Thus, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed. Androstenedione is ... Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous ... Androstenedione, also known as androst-4-ene-3,17-dione, is a naturally occurring androstane steroid and a 17-ketosteroid. It ... The primary pathway involves conversion of 17α-hydroxypregnenolone to DHEA by way of 17,20-lyase, with subsequent conversion of ...
... and 20-ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans. AKR1A1; AKR1B1; AKR1B10; AKR1C1; AKR1C2; ... 17β-HSDsTooltip 17β-hydroxysteroid dehydrogenases, and 20α-HSDsTooltip 20α-Hydroxysteroid dehydrogenases, respectively. The ...
Retrieved 2017-07-17. Rezende L (28 April 2016). "Fabio Maldonado plans to use DHEA for Fedor match, admits use in UFC". Bloody ... 17 January 2014. Archived from the original on 1 February 2014. "Memphis Grizzlies' O. J. Mayo suspended 10 games for violating ... Prasterone, also known as androst-5-en-3β-ol-17-one, is a naturally occurring androstane steroid and a 17-ketosteroid. It is ... 17 (2): 84-89. doi:10.1159/000179680. PMID 6220949. Rauramo L, Punnonen R, Kaihola LH, Grönroos M (January 1980). "Serum ...
Inhibitors of 17β-HSD type II are of interest for the potential treatment of osteoporosis. Some inhibitors of 17β-HSD type I ... Major isoform of 17β-HSD in the granulosa cells of the ovaries. Mutations and associated deficiency have not been reported in ... Wang CT, Li CF, Wu WJ, Huang CN, Li CC, Li WM, Chan TC, Liang PI, Hsing CH, Liao KM (2016). "High Expression of 17β- ... 17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B) (EC 1.1.1.51), also 17-ketosteroid reductases (17-KSR), are a group of ...
... (EC 1.14.13.142, KshAB, 3-ketosteroid 9alpha-hydroxylase) is an enzyme with systematic name ... 3-ketosteroid+9alpha-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... Capyk JK, Casabon I, Gruninger R, Strynadka NC, Eltis LD (November 2011). "Activity of 3-ketosteroid 9α-hydroxylase (KshAB) ... Capyk JK, D'Angelo I, Strynadka NC, Eltis LD (April 2009). "Characterization of 3-ketosteroid 9{alpha}-hydroxylase, a Rieske ...
By age 17, only 10% of adolescent males have persistent gynecomastia. Declining testosterone levels and an increase in the ... Malfitano, Nicholas (17 January 2020). "Judge in landmark $8 billion Risperdal case cuts punitive damages award down to $6.8 ... Retrieved 17 November 2020. Iuanow, Elaine; Kettler, Mark; Slanetz, Priscilla J. (March 2011). "Spectrum of Disease in the Male ... 132 (S1): 17-26. doi:10.1007/s00432-006-0133-5. PMID 16845534. S2CID 23888640. Goldspiel, Barry R.; Kohler, David R. (June 1990 ...
... , August 17, 2016, retrieved January 1, 2017 (Articles with short description, Short description matches Wikidata, ... Process for the preparation of 9alpha-chloro-11beta-hydroxy steroids, retrieved 2015-12-07 Savage S (2008-09-17). "DFB Sells ... Through the measurements of plasma cortisol and urinary 17-ketosteroid levels, the investigators monitored effects on the HPA ...
21-dihydroxy-20-ketosteroids by microbiological hydration with Streptomyces hydrogenans]. Hoppe-Seyler's Z Physiol Chem. 313: ... "Gewinnung von 20β-Hydroxysteroiden aus 17α.21-Dihydroxy-20-ketosteroiden durch mikrobiologische Hydrierung mit Streptomyces ... hydrogenans" [Production of 20 beta-hydroxysteroids from 17 alpha, ...
It is the 17β-(1-methoxycyclohexane) ether of 1-testosterone (dihydroboldenone). Syntheses of mesabolone have been published. ... Mesabolone, also known as 1-testosterone 17β-methoxycyclopentyl ether, is a synthetic anabolic-androgenic steroid (AAS) that ... Process for the preparation of 16α-methyl-16β-halomethyl-17-ketosteroids]", published 1964-03-12, assigned to Merck AG Vitali R ... "Verfahren zur Herstellung von 16α-Methyl-16β-halogenmethyl-17-ketosteroiden [ ...
... is a steroid from the androstane class containing a ketone and a hydroxyl group at positions three and seventeen ... 24 (1): 17-28. PMID 19403051. Xu HY, Zhang HX, Xiao Z, Qiao J, Li R (2019). "Regulation of anti-Müllerian hormone (AMH) in ... In the hepatic 17-ketosteroid pathway of testosterone metabolism, testosterone is converted in the liver by 5α-reductase and 5β ... 17 (5): 399-408. doi:10.1038/sj.ijir.3901334. PMID 15889125. Sorokowski P, et al. (October 2019). "Romantic Love and ...
They also transplanted tumors from one mouse to another, isolated 17-ketosteroids from their own urine, and did blood counts ... 17′12″N 71°43′41″W / 42.2867°N 71.7281°W / 42.2867; -71.7281 v t e (Articles with short description, Short description ...
17-diol MeSH D06.472.334.851.968.750 - androstenediol MeSH D06.472.334.851.968.875 - androstenedione MeSH D06.472.334.851. ... 17-ketosteroids MeSH D06.472.040.502.112 - androstenedione MeSH D06.472.040.502.195 - androsterone MeSH D06.472.040.502.497 - ... 17-hydroxycorticosteroids MeSH D06.472.040.585.478.195 - cortisone MeSH D06.472.040.585.478.225 - cortodoxone MeSH D06.472. ... 17-alpha-hydroxypregnenolone MeSH D06.472.317.152 - cholecystokinin MeSH D06.472.317.152.700 - sincalide MeSH D06.472.317.350 ...
17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other ... 17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other ...
Learn about 17-Ketosteroids at online-medical-dictionary.org ...
"17-Ketosteroids" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "17-Ketosteroids" by people in this website by year, and ... Below are the most recent publications written about "17-Ketosteroids" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "17-Ketosteroids". ...
Karaoli & Dimitriou 17, PC: 57001,. Tel: 2310460040 TOMOGRAPHY:. Stratigou Kallari 3, PC: 54622,. Tel: 2310288132. www. ...
The reference range of urinary 17-ketosteroids is as follows: Males: 10-20 mg (34-69 µmol)/24 h Females: 5-15 mg (17-52 µmol)/ ... The 17-ketosteroids are breakdown products of androgens. Examples of 17-ketosteroids include androstenedione, androsterone, ... encoded search term (17-Ketosteroids) and 17-Ketosteroids What to Read Next on Medscape ... Newer tests have superseded 17-ketosteroid testing, and the assay is seldom used now. ...
The reference range of urinary 17-ketosteroids is as follows: Males: 10-20 mg (34-69 µmol)/24 h Females: 5-15 mg (17-52 µmol)/ ... The 17-ketosteroids are breakdown products of androgens. Examples of 17-ketosteroids include androstenedione, androsterone, ... encoded search term (17-Ketosteroids) and 17-Ketosteroids What to Read Next on Medscape ... Newer tests have superseded 17-ketosteroid testing, and the assay is seldom used now. ...
A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C=O) group. A 17- ... ketosteroid is a ketosteroid in which the ketone is located specifically at the C17 position (in the upper right corner of most ... Hydroxysteroid Hydroxysteroid dehydrogenase 17-Ketosteroids at the U.S. National Library of Medicine Medical Subject Headings ( ... Examples of 17-ketosteroids include: Androstenedione Androstanedione Androsterone Dehydroepiandrosterone Epiandrosterone ...
Home Pathology 17 - HYDROXYCORTICOSTEROIDS & 17 - KETOSTEROIDS, 24-HOUR URINE. 17 - HYDROXYCORTICOSTEROIDS & 17 - KETOSTEROIDS ... 16/17,Oba Amusa Avenue, Idimu, Ikotun, Lagos.. PHONE: 070 1404 0181 ...
The preprint of the paper Universal Capability of 3-Ketosteroid Δ1-Dehydrogenases to Catalyze Δ1-Dehydrogenation of C17- ... MLBKE scientists managed to show that 3-ketosteroid dehydrogenases (KSTD) exhibit universal capabilities of catalysing ... dehydrogenation of 3-ketosteroids with undegraded C-17 substituent (this long black chain sticking out of the enzyme in the ...
Levels of 17-hydroxycorticosteroids and 17-ketosteroids in maternal and cord plasma in term anencephaly. The Journal of ... Levels of 17-hydroxycorticosteroids and 17-ketosteroids in maternal and cord plasma in term anencephaly. / NICHOLS, J.; LESCURE ... Levels of 17-hydroxycorticosteroids and 17-ketosteroids in maternal and cord plasma in term anencephaly.. ... title = "Levels of 17-hydroxycorticosteroids and 17-ketosteroids in maternal and cord plasma in term anencephaly.", ...
17] More than 90% of these patients had characteristic symptoms suggesting the unrecognized tumors were not silent. Many of the ... Approximately 29% died unexpectedly during surgery, 27% died from cardiovascular causes, and 17% died from cerebrovascular ...
Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. Testosterone is the ... Because of the hepatotoxicity associated with the use of 17-alpha-alkylated androgens, liver function tests should be obtained ... Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the ... Cholestatic hepatitis and jaundice occur with 17-alpha-alkylandrogens at a relatively low dose. If cholestatic hepatitis with ...
Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. Testosterone is the ... Anticoagulants C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the ... Cholestatic hepatitis and jaundice occur with 17-alpha-alkylandrogens at a relatively low dose. If cholestatic hepatitis with ... Because of the hepatotoxicity associated with the use of 17-alpha-alkylated androgens, liver function tests should be obtained ...
1960;17:279-308.. Vojtechovsky M, Grof S, V tek V, Rys nek K, Bultasov H. "Experimentalpsychose als Folge der Verabreichung von ... The excretion of 17-ketosteroids was reduced by benactyzine and increased by LSD. ...
Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with development of hepatic ... Testosterone is metabolized to various 17-keto steroids through two different pathways.. The half-life of testosterone ... The chemical name for testosterone cypionate is androst-4-en-3-one, 17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular ... Testosterone cypionate injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 ( ...
Specimen Collection Guides and Resources at Meadville Medical Center | This section includes specimen collection information for the laboratory, microbiology, pathology, and blood bank. Reference materials such as log sheets for reference specimens, instructions for using a lock box, and courier specimen packing lists are also available. Consult separate information for microbiology, pathology, and blood bank specimens on their respective pages.
The biologically most active estrogen is 17 ß-estradiol. This is a steroid hormone having a molecular weight of 272 daltons. ... In vitro tests were performed on 17 commonly used pharmaceuticals. No interference with the assay was found. In isolated cases ... Elecsys Estradiol II employs a competitive test principle using a polyclonal antibody specifically directed against 17 ß- ... whereas C19 17-ketosteroids such as dehydroepiandrosterone (DHEA) and androstendione do not bind so easily. SHBG has a high ...
17-Ketosteroid Excretion in Men with Gout (1 September, 1957) E. R. Cook, G. D. Kersley, M. Luscombe ...
Chicken 17-ketosteroids,17-KS ELISA kit 雞17-酮類固醇(17-KS)ELISA試劑盒. 96T/48T. ... Chicken Interleukin 17,IL-17 ELISA kit 雞白介素17(IL-17)ELISA試劑盒 96T/48T. ... Hydroxycorticosteroids,17-OHCS ELISA kit 雞17羥皮質類固醇(17-OHCS)ELISA試
Females with 17-hydroxylase deficiency appear phenotypically female at birth but do not develop breasts or menstruate in ... CYP21A is the gene that codes for 21-hydroxylase, CYP11B1 codes for 11-beta-hydroxylase, and CYP17 codes for 17-alpha- ... Basal 17-hydroxyprogesterone cannot accurately predict nonclassical congenital adrenal hyperplasia in children and adolescents ... Hypertensive forms of adrenal hyperplasia (ie, 11-beta-hydroxylase deficiency and 17-alpha-hydroxylase deficiency) are ...
For in vitro investigation, GH3 rat pituitary cells were exposed to vehicle, 17β-estradiol (E2), or D4 with/without ICI 182 780 ... Two-way analysis of variance showed a negative association between serum PCBs and both total glucuronidated 17-KS and total and ... Both the urinary concentrations of the total 17-KS and pregnanes, and those of some single steroids and their glucuronidated ... Womens blood samples were collected for assay of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-Estradiol ( ...
... By Miriam Pollak 04.06.2017 Dehydroepiandrosterone (DHEA); 4-androstene-3, ... 2016) "Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization ... 17-dione (AD); and testosterone are androgenic 19-carbon steroids that serve as precursors for other male and female sex ...
01010006583 Chicken 17-ketosteroids (17-KS) ELISA Kit Info ab-elisa elisas AE22895CH 48 wells plate Ask Ask ...
01010006583 Chicken 17-ketosteroids (17-KS) ELISA Kit Info ab-elisa elisas AE22895CH 48 wells plate Ask Ask ...
Urine Tests: Normal Values - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
... ketosteroids, pantothenic acid, phenolsulfonphthalein (PSP), sulfonamides, and sulfonylureas. See also Drug Interactions. ...
Find Pathology Lab and Diagnostic Centre in Rajapeth from Metropolis Healthcare, Get facility of Home Sample Collection, Download Test Reports Online, Certified Labs & Centres Across India
Learn about the first line treatments for endogenous Cushings syndrome and explore resources related to the Endocrine Societys clinical practice guideline, Treatment of Cushings Syndrome.
  • Steroids that contain a ketone group at position 17. (online-medical-dictionary.org)
  • Endogenous androgens are C-19 steroids with a side chain at C-17, and with two angular methyl groups. (theodora.com)
  • Testosterone is metabolized to various 17-keto steroids through two different pathways. (nih.gov)
  • When considering a cutting cycle is that you are low sperm count, "bitch tits", acne, extra body 17-keto steroids through two different pathways. (raveable.com)
  • Testosterone cypionate injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic hormone testosterone. (nih.gov)
  • The excretion of 17-ketosteroids was reduced by benactyzine and increased by LSD. (erowid.org)
  • 17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other hormones released by the adrenal glands in males and females, and by the testes in males. (medlineplus.gov)
  • The 17-ketosteroids are breakdown products of androgens. (medscape.com)
  • Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis -all potentially life-threatening complications. (pfizermedicalinformation.com)
  • Examples of 17-ketosteroids include: Androstenedione Androstanedione Androsterone Dehydroepiandrosterone Epiandrosterone Epietiocholanolone Etiocholanolone 17-Ketosteroids are endogenous steroid hormones. (wikipedia.org)
  • Hammond GL, 1995) whereas C19 17-ketosteroids such as dehydroepiandrosterone (DHEA) and androstendione do not bind so easily. (cdc.gov)
  • Levels of 17-hydroxycorticosteroids and 17-ketosteroids in maternal and cord plasma in term anencephaly. (johnshopkins.edu)
  • Congenital adrenal hyperplasia (CAH), partial androgen insensitivity syndrome, hypospadias, epispadias, bladder and cloacal exstrophy, Klinefelter syndrome, enzyme insufficiencies like 5-alpha reductase or 17-beta ketosteroid, and MRKH, CHARGE, and other syndromes all may have ambiguous genitalia as part of their presentation. (heainfo.org)
  • A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C=O) group. (wikipedia.org)
  • A 17-ketosteroid is a ketosteroid in which the ketone is located specifically at the C17 position (in the upper right corner of most structure diagrams). (wikipedia.org)
  • In fish, the gonadotropin induces 17α, 20ß-dihydroxy-4-pregnen-3-one (DHP) production, an important steroid hormone involved in gametogenesis. (bvsalud.org)
  • In some cases, levels of 17-ketosteroids and aldosterone are slightly elevated, and this plays a role in the clinical manifestations of the disease. (pediagenosis.com)
  • Newer tests have superseded 17-ketosteroid testing, and the assay is seldom used now. (medscape.com)
  • This graph shows the total number of publications written about "17-Ketosteroids" by people in this website by year, and whether "17-Ketosteroids" was a major or minor topic of these publications. (rush.edu)
  • MLBKE scientists managed to show that 3-ketosteroid dehydrogenases (KSTD) exhibit universal capabilities of catalysing dehydrogenation of 3-ketosteroids with undegraded C-17 substituent (this long black chain sticking out of the enzyme in the figure below). (mlbke.com)
  • The substrate spectrum of N. simplex 3-ketosteroid-Δ 1 -dehydrogenase was expanded in this study with progesterone and its 17α-hydroxylated and 11α,17α-dihydroxylated derivatives, that effectively were 1(2)-dehydrogenated in vivo by the whole cells of the N. simplex VKM Ac-2033D. (biomedcentral.com)
  • May cause a decrease in excretion of creatinine and creatine and increase in excretion of 17-ketosteroids. (concentrexlabs.com)
  • A study by Adriaansen et al suggested that salivary samples of the 17-ketosteroid androstenedione as well as of another steroid, 17-hydroxyprogesterone, can be used to monitor the efficacy of treatment in congenital adrenal hyperplasia. (medscape.com)
  • A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C=O) group. (wikipedia.org)
  • Examples of 17-ketosteroids include: Androstenedione Androstanedione Androsterone Dehydroepiandrosterone Epiandrosterone Epietiocholanolone Etiocholanolone 17-Ketosteroids are endogenous steroid hormones. (wikipedia.org)
  • The unusual pattern of plasma and urinary steroids indicated that this child had multiple abnormalities of steroid-biosynthetic microsomal mixed-function oxidases--21-hydroxylase, 17 alpha-hydroxylase, and 17,20 desmolase. (nih.gov)
  • Diurnal salivary androstenedione and 17-hydroxyprogesterone levels in healthy volunteers for monitoring treatment efficacy of patients with congenital adrenal hyperplasia. (medscape.com)
  • 13. [Excretion of estrogens and 17-ketosteroids in patients with different histological forms of testicular tumors before and during chemotherapy]. (nih.gov)
  • Aldo-Keto-Reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase (HSD)/prostaglandin (PG) F2α synthase) is the only 17β-HSD that is not a short-chain dehydrogenase/reductase. (nih.gov)
  • The glutamate-histidine substitution prevents a 3-ketosteroid from penetrating the active site so that hydride transfer is directed toward the C3 carbonyl group rather than the Δ(4)-double bond and confers 3β-HSD activity on the 5β-reductase. (anl.gov)
  • AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders. (nih.gov)
  • AKR1D1 catalyzes the 5β-reduction of Δ(4)-3-ketosteroids, whereas AKR1C enzymes are hydroxysteroid dehydrogenases (HSDs). (anl.gov)
  • 17. Molecular heterogeneity of chorionic gonadotropin in some testicular cancer patients. (nih.gov)
  • We measured 17 dioxin congeners, 12 dioxin-like PCBs, and 6 indicator PCBs in placenta using gas chromatography coupled with high-resolution mass spectrometry. (nih.gov)
  • For estrogen secreting tumors, high blood estrogen and urine 17-ketosteroids help make the diagnosis. (monpresident.org)
  • Its almost complete destruction and transformation into 17-ketosteroids occurs in the liver and partially in the tissues. (save-as-dance.org)
  • Merriam-Webster.com Dictionary , Merriam-Webster, https://www.merriam-webster.com/dictionary/ketosteroid. (merriam-webster.com)
  • A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. (nih.gov)
  • In the medical field, 1,3-DNB has been used as an indicator in the detection of 17-ketosteroids. (cdc.gov)
  • Search Medline for 3-ketosteroid 9alpha-hydroxylase . (ethz.ch)
  • 17 alpha-hydroxylase deficiency: mineralocorticoid hormone profiles in an affected family. (nih.gov)
  • Tiene un total de cuatro enlaces dobles en los anillos A- y B-. Se encuentran altas concentraciones de equilina en la ORINA de yeguas preñadas. (bvsalud.org)
  • High resolution crystal structures of the E120H mutant in complex with epiandrosterone, 5β-dihydrotestosterone, and Δ(4)-androstene-3,17-dione elucidated the structural basis for this functional change. (anl.gov)
  • In 1947, Dr. Forbes debuted as first author in the Journal of Clinical Endocrinology with "The Effect of Trauma and Disease on the Urinary 17-Ketosteroid Excretion in Man. (columbiamedicinemagazine.org)