A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.
Tumors or cancer of the PROSTATE.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Compounds that bind to and stimulate PURINERGIC P2Y RECEPTORS. Included under this heading are agonists for specific P2Y receptor subtypes.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
A slightly alkaline secretion of the endocervical glands. The consistency and amount are dependent on the physiological hormone changes in the menstrual cycle. It contains the glycoprotein mucin, amino acids, sugar, enzymes, and electrolytes, with a water content up to 90%. The mucus is a useful protection against the ascent of bacteria and sperm into the uterus. (From Dictionary of Obstetrics and Gynecology, 1988)
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
The removal of secretions, gas or fluid from hollow or tubular organs or cavities by means of a tube and a device that acts on negative pressure.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.
A highly contagious DNA virus infection of the cat family, characterized by fever, enteritis and bone marrow changes. It is also called feline ataxia, feline agranulocytosis, feline infectious enteritis, cat fever, cat plague, and show fever. It is caused by FELINE PANLEUKOPENIA VIRUS or the closely related MINK ENTERITIS VIRUS or CANINE PARVOVIRUS.
The motor activity of the GASTROINTESTINAL TRACT.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Inflammation of any segment of the SMALL INTESTINE.
Analogs or derivatives of prostaglandins E that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
Aspects of health and disease related to travel.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
Physiologically active prostaglandins found in many tissues and organs. They show pressor activity, are mediators of inflammation, and have potential antithrombotic effects.
The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.
Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.
Bickel, Martin; Kauffman, Gordon L. (April 1981). "Gastric gel mucus thickness: Effect of distention, 16,16-dimethyl ... prostaglandin E2, and carbenoxolone". Gastroenterology. 80 (4): 770-775. doi:10.1016/0016-5085(81)90139-6. PMID 6162705. Celli ...
16,16-dimethylprostaglandin e2 MeSH D10.251.355.255.550.700.450.350 - enprostil MeSH D10.251.355.255.550.700.450.500 - ...
... adenovirus e2 proteins MeSH D23.050.327.045.070 - adenovirus e3 proteins MeSH D23.050.327.045.080 - adenovirus e4 proteins MeSH ... interleukin-16 MeSH D23.348.505.517 - interleukin-17 MeSH D23.348.505.518 - interleukin-18 MeSH D23.348.580.675 - cdc2 protein ... 16,16-dimethylprostaglandin e2 MeSH D23.469.700.660.250 - enprostil MeSH D23.469.700.660.500 - misoprostol MeSH D23.469.700.660 ...
Minghetti L, Pocchiari M (2007). "Cyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases". Int. Rev. ... PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently, ... 89 (16): 7384-8. Bibcode:1992PNAS...89.7384H. PMC 49714 . PMID 1380156. doi:10.1073/pnas.89.16.7384.. ... 16] The 13-pro(S) -hydrogen is abstracted and dioxygen traps the pentadienyl radical at carbon 11. The 11-peroxyl radical ...
Cavar I (2010). "The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice". Histol Histopathol. 25 (7): 819- ...
This article is about the pharmaceutical agent 'dinoprost'. For the drug 'dinoprostone', see Prostaglandin E2. ... This page was last edited on 22 June 2019, at 16:18 (UTC). ...
A.; Kirichek, L. M.; Endel'man, É. S.; Get'man, G. A. (1977). "Mefenamic acid - A Nonsteroid Antiinflammatory Agent". ... InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18) Y ...
162 (1): 115-24.e2. doi:10.1016/j.ahj.2011.04.006. PMID 21742097.. ... 16 (5): 251-4. doi:10.2500/108854195778702675. PMID 8566739.. *^ a b "PDR guide to over the counter (OTC) drugs". Archived from ... 379 (16): 1509-1518. doi:10.1056/NEJMoa1805819. PMC 6289056. PMID 30221597.. *^ a b Algra AM, Rothwell PM (May 2012). "Effects ... 379 (16): 1499-1508. doi:10.1056/NEJMoa1800722. PMID 30221596.. *^ a b McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, ...
Prostaglandin E2 receptor 4 (EP4). അവലംബം[തിരുത്തുക]. *↑ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000050628 - Ensembl, May ... Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, Maruyama T, Wang J (June 2016). "Inhibition of prostaglandin E2 receptor EP3 ... An S, Yang J, So SW, Zeng L, Goetzl EJ (December 1994). "Isoforms of the EP3 subtype of human prostaglandin E2 receptor ... Richards JA, Brueggemeier RW (June 2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose ...
Comparison of methylated prostaglandin E2 analogues given orally in the inhibition of gastric responses to pentagastrin and ... Effect of 16, 16-dimethyl prostaglandin E2 methyl ester on gastric secretion induced by pentagastrin and pepton meal in man. ... In 14 healthy male volunteers the effect of 16,16-dimethyl PGE2 methyl ester (PG/D) on gastric secretion have been studied. ... Inhibition of gastric secretion in the dog by 16,16-dimethyl prostaglandin E2. (opens in new tab) ...
The purpose of this study was to investigate the effects of exogenous dimethylprostaglandin E2 (dmPGE2) on prostate cancer cell ... Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells Br J Cancer. 1997;75(8):1111-8. doi ...
16,16-dimethylprostaglandin E2. A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and ...
Bickel, M; Kauffman, GL (Apr 1981). "Gastric gel mucus thickness: effect of distention, 16,16-dimethyl prostaglandin e2, and ...
... dimethylprostaglandin E2 or E2, dinoprostone; Prepidil, Cervidil, Dinoprost, Carboprost or hemabate; prostin, oxytocin, ... dimethylprostaglandin E2 or E2; dinoprostone; Prepidil; Cervidil: Dinoprost; Carboprost or hemabate; prostin, oxytocin, ... Prostaglandin E2 (PGE2) and vaginal misoprostol were more effective than oxytocin in bringing about vaginal delivery within 24 ... Our search identified one Cochrane systematic review of vaginal prostaglandin E2 (PGE2) or F2α (PGF2α) [14]. Within this review ...
16,16-Dimethylprostaglandin E2 / administration & dosage, pharmacology. Acute Disease. Animals. Biliary Tract Diseases / ... Simultaneous infusion of 16-16 dimethyl-PgE2 converts edematous pancreatitis to acute hemorrhagic pancreatitis (AHP). AHP may ...
11-deoxy-16,16-dimethyl-Prostaglandin E2. Exact Mass. 364.2614 (neutral) Calculate m/z: (Select m/z). [M+H]+. [M+H-H2O]+. [M.]+ ... 9-oxo-15R-hydroxy-16,16-dimethyl-5Z,13E-prostadienoic acid. Synonyms. ...
Regulation of mucus secretion has been coupled to neural, hormonal, and paracrine effects (2, 9, 15, 16, 23, 33, 40). Normally ... The mean thickness of the remaining firmly adherent mucus gel varied from 6 to 24 μm (mean thickness, 16 ± 3 μm) in the six ... 2 and Table 1). Suction removed about two-fifths of the mucus layer, leaving a 154 ± 16-μm-thick, firmly adherent, continuous ... 1984) Anti-oxidant protection: a function of tracheobronchial and gastrointestinal mucus. Lancet 16:1328-1330. ...
... cyclooxygenase-2 and prostaglandin E2. We further demonstrated that transplantation of iPS cells markedly inhibited BLM- ... fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 ... 2009). 16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis. ...
Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via ... TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and ... prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kappaB pathways. Cell Signal 18: 1235-1243, 2006. ... 16.↵ *Hwang D. . Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived ...
19 Absence of Prostaglandin E2-lnduced Radioprotection in Two Cell Lines Lacking Specific PGE2-Binding Sites.- 20 Radiation- ... 16-Dimethyl Prostaglandin E2 Pretreatment and/or Bone Marrow Transplantation After Supra-Lethal Whole Body Irradiation.- 59 ... 16 Radiation Protection and Cancer Therapy by Linoleate.- Lipid Peroxidation, Eicosanoid biosynthesis, and Radiation induced ...
Regulation of macrophage tumor necrosis factor production by prostaglandin E2. Biochem. and Biophys. Res. Comm. 137:404-410. ... Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. Biochem. Biophys. Res. ... 16.. Levy, G.A., Leibowitz, J.L., Edgington, T.S. 1981. Induction of monocyte procoagulant activity by murine hepatitis virus ... 16, 16 dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/ ...
Each of the patients received two umbilical cord blood units, one untreated and another treated with the small molecule, 16,16 ... dimethyl prostaglandin E2 (dmPGE2). All 12 patients had reconstitution of their immune systems and renewed blood formation, and ... which is this 16,16 dimethyl prostaglandin E2, that gave an incredible expansion of stem cells about a 300 to 400 percent ...
The generation of prostaglandin E2- and prostaglandin I2-like activity in the gastric mucosa was unaltered by adrenalectomy [41 ... Synthesis of prostaglandin E2 and 6-keto prostaglandin F1 alpha by cultured antral and fundic gastric mucosa obtained from 86 ... Gastric mucosal blood flow in rats after administration of 16,16-dimethyl prostaglandin E2 at a cytoprotective dose. Leung, F.W ... Isolated human gastric glands from surgical specimens were preincubated in an oxygenated medium with placebo or 16,16 dimethyl ...
16,16-dimethylprostaglandin e2 MeSH D10.251.355.255.550.700.450.350 - enprostil MeSH D10.251.355.255.550.700.450.500 - ...
16, 16-dimethyl prostaglandin E2, or dmPGE2, modulated cord blood) in adult patients undergoing hematopoietic stem cell (HSC) ...
PROHEMA (16, 16-dimethyl prostaglandin E2, or dmPGE2, modulated cord blood), the Companys lead pharmacologically-modulated HSC ...
Isolated human gastric glands from surgical specimens were preincubated in an oxygenated medium with placebo or 16,16 dimethyl ... prostaglandin E2 (dmPGE2) and incubated at 37 degrees C in either medium alone, medium containing 4.43 mM indomethacin or ...
High-dose treatment for 16 wk further enhanced bone volume (50.4 +/- 4.61%) and trabecular number (3.90 +/- 0.5/mm). These ... Isolated human gastric glands from surgical specimens were preincubated in an oxygenated medium with placebo or 16,16 dimethyl ... prostaglandin E2 (dmPGE2) and incubated at 37 degrees C in either medium alone, medium containing 4.43 mM indomethacin or ...
Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Peters, L.L., ... Expression of p45 NF-E2 messenger RNA was detected in erythroid tissues of normal mice and in the duodenum of normal and ... and extracts were assayed for prostaglandin F2 alpha and E2 concentrations by radioimmunoassay [42]. ... Effect of flurbiprofen and 16,16-dimethyl-prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N-nitro-N- ...
5 or 7 or 15 or 16. * Limit 17 to (embryo or infant or child or preschool child ,1 to 6 years, or school child ,7 to 12 years, ... Emerg Infect Dis 2011;17:16-22. * 2. Scallan E, Hoekstra RM, Angulo FJ et al. Foodborne illness acquired in the United States- ... 16. Mearin F, Perello A, Balboa A et al. Pathogenic mechanisms of postinfectious functional gastrointestinal disorders: results ... Curr Infect Dis Rep 2014;16:434. *55. Gaudreau C, Barkati S, Leduc JM et al. Shigella spp. with reduced azithromycin ...
Calapre, L., Gray, E. S., Kurdykowski, S., David, A., Hart, P., Descargues, P. & Ziman, M., 2016, In : BMC Dermatology. 16, 1, ... Hart, P. H., Norval, M. & Reeve, V. E., 2017, In : Photochemical and Photobiological Sciences. 16, 3, p. 281-282 2 p.. Research ... 16, 3, p. 381-398 18 p.. Research output: Contribution to journal › Article ...
Sequence analysis reveals extensive polymorphism and evidence of deletions within the E2 glycoprotein gene of several strains ... 16.↵. Levy, G. A., G. Adamson, M. J. Phillips, L. A. Scrocchi, L. Fung, P. Biessels, N. F. Ng, A. Ghanekar, A. Rowe, M. X. Ma, ... 16,16-Dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage ... 16). Likewise, in our experiments, reduced viral titers were found to result in a reduction of liver necrosis, yet the lethal ...
Guinea Pig에서 16,16-Dimethyl Prostaglandin E2와 콜레스테롤이 담즙의 점액성 당단백질과 담석형성에 미치는영향, 국내공인학술지(이전), 34권,6호, 784~792, 1999. ... 직장에 발생한 원발성 악성흑색종, 국내공인학술지(이전), 16권 6호, 478~482, 2000. ...
16,16-dimethylprostaglandin E2 A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and ...
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1. A range of naturally-occurring prostaglandins sulprostone, 16,16-dimethyl prostaglandin E2 (DME2) and the thromboxane A2 ( ...
Prostaglandin E2 (PGE2)-mediated mechanisms, which have potential to downregulate CCR5 expression in umbilical cord bloodrn(UCB ... PGE2 derivative (16, 16 dimethylprostaglandin E2; dmPGE2) was recently identifi edrnto be a critical regulator of HSC ...
Expression analysis of GPCR showed that the prostacyclin, prostaglandin E2 (PGE2) receptor 2 and 4, melanocortin-1, β2 ... Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. Prostanoid receptor 2 signaling and cyclic adenosine ... The endogenous EP receptor agonist PGE2 has been shown to inhibit cellular markers of fibrosis [14, 16], and its synthetic ... 16,16-dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis. ...

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