14 3 3 proteins. Medical search

Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Electrophoresis in which a starch gel (a mixture of amylose and amylopectin) is used as the diffusion medium.

A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))

An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.

A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.

An Arabidopsis 14-3-3 protein can act as a transcriptional activator in yeast. (1/1483)

The 14-3-3 proteins are a group of highly conserved and widely distributed eukaryotic proteins with diverse functions. One 14-3-3 protein, AFT1 from Arabidopsis thaliana, was found to be able to activate transcription in yeast. When fused to the DNA-binding domain of a bacterial protein LexA, AFT1 can activate transcription of reporter genes that contain LexA operator sequences in their promoters. Although the in vivo function of AFT1 is not completely known, its similarity to previously identified proteins found in transcription complexes of Arabidopsis and maize suggests that AFT1 and some other 14-3-3 proteins may activate gene expression in other systems as well. (+info)

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins. (2/1483)

Integrin ligand binding induces a signaling complex formation via the direct association of the docking protein p130(Cas) (Cas) with diverse molecules. We report here that the 14-3-3zeta protein interacts with Cas in the yeast two-hybrid assay. We also found that the two proteins associate in mammalian cells and that this interaction takes place in a phosphoserine-dependent manner, because treatment of Cas with a serine phosphatase greatly reduced its ability to bind 14-3-3zeta. Furthermore, the Cas-14-3-3zeta interaction was found to be regulated by integrin-mediated cell adhesion. Thus, when cells are detached from the extracellular matrix, the binding of Cas to 14-3-3zeta is greatly diminished, whereas replating the cells onto fibronectin rapidly induces the association. Consistent with these results, we found that the subcellular localization of Cas and 14-3-3 is also regulated by integrin ligand binding and that the two proteins display a significant co-localization during cell attachment to the extracellular matrix. In conclusion, our results demonstrate that 14-3-3 proteins participate in integrin-activated signaling pathways through their interaction with Cas, which, in turn, may contribute to important biological responses regulated by cell adhesion to the extracellular matrix. (+info)

Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. (3/1483)

Recent studies have documented direct interaction between 14-3-3 proteins and key molecules in signal transduction pathways like Ras, Cbl, and protein kinases. In T cells, the 14-3-3tau isoform has been shown to associate with protein kinase C theta and to negatively regulate interleukin-2 secretion. Here we present data that 14-3-3tau interacts with protein kinase C mu (PKCmu), a subtype that differs from other PKC members in structure and activation mechanisms. Specific interaction of PKCmu and 14-3-3tau can be shown in the T cell line Jurkat by immunocoprecipitiation and by pulldown assays of either endogenous or overexpressed proteins using PKCmu-specific antibodies and GST-14-3-3 fusion proteins, respectively. Using PKCmu deletion mutants, the 14-3-3tau binding region is mapped within the regulatory C1 domain. Binding of 14-3-3tau to PKCmu is significantly enhanced upon phorbol ester stimulation of PKCmu kinase activity in Jurkat cells and occurs via a Cbl-like serine containing consensus motif. However, 14-3-3tau is not a substrate of PKCmu. In contrast 14-3-3tau strongly down-regulates PKCmu kinase activity in vitro. Moreover, overexpression of 14-3-3tau significantly reduced phorbol ester induced activation of PKCmu kinase activity in intact cells. We therefore conclude that 14-3-3tau is a negative regulator of PKCmu in T cells. (+info)

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (4/1483)

Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9. In this study, we demonstrate that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors. In the presence of survival factors, Akt phosphorylates FKHRL1, leading to FKHRL1's association with 14-3-3 proteins and FKHRL1's retention in the cytoplasm. Survival factor withdrawal leads to FKHRL1 dephosphorylation, nuclear translocation, and target gene activation. Within the nucleus, FKHRL1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene. (+info)

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. (5/1483)

The Ca2+-activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis. The Ca2+-induced dephosphorylation of BAD correlated with its dissociation from 14-3-3 in the cytosol and translocation to mitochondria where Bcl-xL resides. In hippocampal neurons, L-glutamate, an inducer of Ca2+ influx and calcineurin activation, triggered mitochondrial targeting of BAD and apoptosis, which were both suppressible by coexpression of a dominant-inhibitory mutant of calcineurin or pharmacological inhibitors of this phosphatase. Thus, a Ca2+-inducible mechanism for apoptosis induction operates by regulating BAD phosphorylation and localization in cells. (+info)

Fusicoccin, 14-3-3 proteins, and defense responses in tomato plants. (6/1483)

Fusicoccin (FC) is a fungal toxin that activates the plant plasma membrane H+-ATPase by binding with 14-3-3 proteins, causing membrane hyperpolarization. Here we report on the effect of FC on a gene-for-gene pathogen-resistance response and show that FC application induces the expression of several genes involved in plant responses to pathogens. Ten members of the FC-binding 14-3-3 protein gene family were isolated from tomato (Lycopersicon esculentum) to characterize their role in defense responses. Sequence analysis is suggestive of common biochemical functions for these tomato 14-3-3 proteins, but their genes showed different expression patterns in leaves after challenges. Different specific subsets of 14-3-3 genes were induced after treatment with FC and during a gene-for-gene resistance response. Possible roles for the H+-ATPase and 14-3-3 proteins in responses to pathogens are discussed. (+info)

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. (7/1483)

Cdc2-cyclin B1 in the G2-arrested Xenopus oocyte is held inactive by phosphorylation of Cdc2 at two negative regulatory sites, Thr14 and Tyr15. Upon treatment with progesterone, these sites are dephosphorylated by the dual specificity phosphatase, Cdc25, leading to Cdc2-cyclin B1 activation. Whereas maintenance of the G2 arrest depends upon preventing Cdc25-induced Cdc2 dephosphorylation, the mechanisms responsible for keeping Cdc25 in check in these cells have not yet been described. Here we report that Cdc25 in the G2-arrested oocyte is bound to 14-3-3 proteins and that progesterone treatment abrogates this binding. We demonstrate that Cdc25, apparently statically localized in the cytoplasm, is actually capable of shuttling in and out of the oocyte nucleus. Binding of 14-3-3 protein markedly reduces the nuclear import rate of Cdc25, allowing nuclear export mediated by a nuclear export sequence present in the N-terminus of Cdc25 to predominate. If 14-3-3 binding to Cdc25 is prevented while nuclear export is inhibited, the coordinate nuclear accumulation of Cdc25 and Cdc2-cyclin B1 facilitates their mutual activation, thereby promoting oocyte maturation. (+info)

The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. (8/1483)

The alpha2-adrenergic receptors (alpha2ARs) are localized to and function on the basolateral surface in polarized renal epithelial cells via a mechanism involving the third cytoplasmic loop. To identify proteins that may contribute to this retention, [35S]Met-labeled Gen10 fusion proteins with the 3i loops of the alpha2AAR (Val217-Ala377), alpha2BAR (Lys210-Trp354), and alpha2CAR (Arg248-Val363) were used as ligands in gel overlay assays. A protein doublet of approximately 30 kDa in Madin-Darby canine kidney cells or pig brain cytosol (alpha2B >/= alpha2C>> alpha2A) was identified. The interacting protein was purified by sequential DEAE and size exclusion chromatography, and subsequent microsequencing revealed that they are the zeta isoform of 14-3-3 proteins. [35S]Met-14-3-3zeta binds to all three native alpha2AR subtypes, assessed using a solid phase binding assay (alpha2A>/=alpha2B> alpha2C), and this binding depends on the presence of the 3i loops. Attenuation of the alpha2AR-14-3-3 interactions in the presence of a phosphorylated Raf-1 peptide corresponding to its 14-3-3 interacting domain (residues 251-266), but not by its non-phosphorylated counterpart, provides evidence for the functional specificity of these interactions and suggests one potential interface for the alpha2AR and 14-3-3 interactions. These studies represent the first evidence for G protein-coupled receptor interactions with 14-3-3 proteins and may provide a mechanism for receptor localization and/or coordination of signal transduction. (+info)

"Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins". Proteins. 65 (3): 643-655. doi: ... Notably, the protein contains three EF hand motifs that function as binding sites for Ca2+ ions. The protein is a member of the ... In the animal, the protein occurs together with the green fluorescent protein to produce green light by resonant energy ... Because the protein is large, it has a low leakage rate from cells compared to lipophilic dyes such as DiI. It lacks phenomena ...

https://en.wikipedia.org/wiki/Aequorin

Protein Science. 14 (3): 812-822. doi:10.1110/ps.04951405. ISSN 0961-8368. PMC 2279270. PMID 15722453. Hulver MW, Berggren JR, ... "Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B ... "Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B ... 3 (4): 271-80. doi:10.2174/1568008033340117. PMID 14683458. Shiwaku K, Hashimoto M, Kitajima K, Nogi A, Anuurad E, Enkhmaa B, ...

https://en.wikipedia.org/wiki/Stearoyl-CoA_9-desaturase

Koyata H, Hiraga K (February 1991). "The glycine cleavage system: structure of a cDNA encoding human H-protein, and partial ... Activity is augmented by high-protein diets and starvation. During periods of low carbohydrates, serine is converted into ... Protein Science. 14 (3): 791-8. doi:10.1110/ps.041179105. PMC 2279282. PMID 15689518. "KEGG ENZYME Database Entry". Kyoto ... Figure 3 and Figure 4). The reaction catalyzed by serine dehydratase follows the pattern seen by other PLP-dependent reactions ...

https://en.wikipedia.org/wiki/Serine_dehydratase

Users can search the database for a particular motion by either protein name or Protein Data Bank ID number. Typically, however ... ISBN 978-0-470-18105-8. Frauenfelder, Hans (10 June 2010). "Chapter 26 on Protein Motions". The Physics of Proteins: An ... users will enter the database via the Protein Data Bank, which often provides a hyperlink to the molmovdb entry for proteins ... Database of protein conformational diversity Gu, Jenny; Bourne, Philip E. (March 2009). Structural Bioinformatics (2nd ed.). ...

https://en.wikipedia.org/wiki/Database_of_Molecular_Motions

The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has ... Draetta G, Eckstein J (1997). "Cdc25 protein phosphatases in cell proliferation". Biochim. Biophys. Acta. 1332 (2): M53-63. doi ... "Protein kinase CK2 regulates CDC25B phosphatase activity". Oncogene. 22 (2): 220-32. doi:10.1038/sj.onc.1206107. ISSN 0950-9232 ... 14 (20): 2485-95. doi:10.1038/sj.onc.1201063. PMID 9188863. Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle ...

https://en.wikipedia.org/wiki/CDC25B

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene. FoxO6 is expressed in the liver, skeletal muscle, and ... 5 (3): 233-40. doi:10.1111/1753-0407.12027. PMC 3657578. PMID 23324123. Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei- ... 587 (14): 2105-11. doi:10.1016/j.febslet.2013.05.027. PMID 23714368. S2CID 38064268. v t e (Articles with short description, ... Tzivion G, Dobson M, Ramakrishnan G (November 2011). "FoxO transcription factors; Regulation by AKT and 14-3-3 proteins". ...

https://en.wikipedia.org/wiki/FOXO6

This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ... "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. ... Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J (1997). "Protein binding and signaling ... Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O (2000). "Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and ...

https://en.wikipedia.org/wiki/YWHAE

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the ... In contrast, some invertebrates harbour two (e.g., the Drosophila proteins String and Twine) or four (e.g., C. elegans Cdc-25.1 ... Dual-specificity protein phosphatases remove phosphate groups from phosphorylated tyrosine and serine / threonine residues. ... Coqueret O, Bérubé G, Nepveu A (1998). "The mammalian Cut homeodomain protein functions as a cell-cycle-dependent ...

https://en.wikipedia.org/wiki/CDC25A

Raf kinases A-Raf kinase B-Raf kinase KSR1 protein KSR2 protein GRCm38: Ensembl release 89: ENSMUSG00000000441 - Ensembl, May ... Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid ... a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". ... and the enzymes dedicated for removal of these phosphates are the protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A ...

https://en.wikipedia.org/wiki/C-Raf

... +protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore- ... Czirják G, Vuity D, Enyedi P (2008). "Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation". J. Biol ...

https://en.wikipedia.org/wiki/KCNK18

The protein can be a toxin, an apoptotic factor, or a viral protein. Toxins such as diphtheria toxin interfere with cellular ... "Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation". FEBS Letters ... Viral proteins like viral thymidine kinase can be used for specific targeting of a drug. By introducing a prodrug only ... hTERT introduction have an advantage over the use of viral protein for immortalization in that it does not involve the ...

https://en.wikipedia.org/wiki/Telomerase_reverse_transcriptase

... camp-responsive element-binding protein (CREB) and CREB-binding protein (CBP). It has been proposed that recruitment of ... Mutant atrophin-1 proteins have been found in neuronal intranuclear inclusions (NII) and diffusely accumulated in the neuronal ... Atrophin-1 may be a dispensable or redundant protein as mice bred with a null allele for atrophin-1 produce viable and fertile ... It contains a putative nuclear localization signal in the N-terminus of the protein and a putative nuclear export signal in the ...

https://en.wikipedia.org/wiki/Dentatorubral–pallidoluysian_atrophy

This protein family is known for regulating signal transduction pathways primarily through binding phosphoserine proteins, ... is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. The protein encoded by this gene is a member of the ... though it can also bind phosphothreonine proteins and unphosphorylated proteins. By extension, 14-3-3 proteins are involved in ... "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Frontiers in ...

https://en.wikipedia.org/wiki/YWHAZ

However, the Hd3a protein is found in neither of these places but instead accumulates in the SAM which shows that Hd3a protein ... CO protein promotes transcription of another gene called Flowering Locus T (FT). By this mechanism, CO protein may only reach ... and is then translated into CO protein. However CO protein is stable only in light, so levels stay low throughout short days ... The FT protein resulting from the short period of CO transcription factor activity is then transported via the phloem to the ...

https://en.wikipedia.org/wiki/Florigen

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene. TLX2 has been shown to interact ... Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling ... proteins". The Journal of Biological Chemistry. 273 (39): 25356-63. doi:10.1074/jbc.273.39.25356. PMID 9738002. v t e (Articles ... "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356-63 ...

https://en.wikipedia.org/wiki/TLX2

The cause was determined to be a histidine-to-tyrosine (amino acid) substitution at position 274 in its neuraminidase protein.[ ... Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins.[citation needed] To ... A single hemagglutinin-neuraminidase protein can combine neuraminidase and hemagglutinin functions, such as in mumps virus and ... Neuraminidase also cleaves sialic acid residues from viral proteins, preventing aggregation of viruses.[medical citation needed ...

https://en.wikipedia.org/wiki/Viral_neuraminidase

ISBN 1-59745-189-4. Anson ML, Protein Denaturation and the Properties of Protein Groups, Advances in Protein Chemistry, 2, 361- ... Protein Sci. 4(10), 2138-2148 (1995) Robertson, A.D., Murphy, K.P. Protein structure and the energetics of protein stability, ( ... 1992) "Physical Basis for the Stability of the Folded Conformations of Proteins", in Protein Folding, TE Creighton, ed., W. H. ... "The use of high-pressure nuclear magnetic resonance to study protein folding". In Bai, Yawen; Nussinov, Ruth (eds.). Protein ...

https://en.wikipedia.org/wiki/Equilibrium_unfolding

... is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ... "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...

https://en.wikipedia.org/wiki/CBL_(gene)

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates ... Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded ... Cheng J, Zhang D, Kim K, Zhao Y, Zhao Y, Su B (Jul 2005). "Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and ... This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a ...

https://en.wikipedia.org/wiki/MAP3K2

... the protein import tunnel Toc75, plus the proteins Toc64 and Toc12. The first three proteins form a core complex that consists ... A protein kinase drifting around on the outer chloroplast membrane can use ATP to add a phosphate group to the Toc34 protein, ... This loss of GTP makes the Toc34 protein release the chloroplast preprotein, handing it off to the next TOC protein. Toc34 then ... Hundreds of different PPR proteins from the nuclear genome are involved in the RNA editing process. These proteins consist of ...

https://en.wikipedia.org/wiki/Chloroplast_DNA

ISBN 978-3-318-02194-3. PMID 24925421 - via S. Karger AG. Cohen, Sheldon (March 2005). "The Ishizakas and the search for ... ISBN 978-3-662-11196-3. Richer, Alice C. (30 April 2009). Food Allergies. ABC-CLIO. p. 8. ISBN 978-0-313-35274-4. "Kimishige ... Kimishige "Kimi" Ishizaka (石坂公成, Ishizaka Kimishige, 3 December 1925 - 6 July 2018) was a Japanese immunologist who, with his ... Cruse, Julius M.; Lewis, Robert E. (14 March 2013). Atlas of Immunology. Springer Science & Business Media. p. 20. ...

https://en.wikipedia.org/wiki/Kimishige_Ishizaka

... or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins ( ... Mutant p53 proteins often fail to induce MDM2, causing p53 to accumulate at very high levels. Moreover, the mutant p53 protein ... In addition to the full-length protein, the human TP53 gene encodes at least 15 protein isoforms, ranging in size from 3.5 to ... One such example, human papillomavirus (HPV), encodes a protein, E6, which binds to the p53 protein and inactivates it. This ...

https://en.wikipedia.org/wiki/P53

... allowing for Rab protein to change from its GDP to GTP bound state. Inhibition of the GTPase-activating domain leaves proteins ... Like all proteins, the unique amino acid arrangement in the primary sequence of GLUT4 is what allows it to transport glucose ... Two proteins with capacity to bind Ubc9 and conjugated to SUMO1". The Journal of Biological Chemistry. 277 (22): 19783-91. doi: ... GLUT4+Protein at the US National Library of Medicine Medical Subject Headings (MeSH) USCD-Nature molecule pages: The signaling ...

https://en.wikipedia.org/wiki/GLUT4

MAP3K5 gene coding for the protein is located on chromosome 6 at locus 6q22.33. and the transcribed protein contains 1,374 ... "Entrez Gene: MAP3K5 mitogen-activated protein kinase kinase kinase 5". Yoon KW, Cho JH, Lee JK, Kang YH, Chae JS, Kim YM, et al ... Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M (June 2002). "Scaffold role of a mitogen-activated protein kinase ... It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response ...

https://en.wikipedia.org/wiki/ASK1

Carr CS, Sharp PA (Aug 1990). "A helix-loop-helix protein related to the immunoglobulin E box-binding proteins". Molecular and ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis ... TFEB is also a target of the protein kinase AKT/PKB. AKT/PKB phosphorylates TFEB at serine 467 and inhibits TFEB nuclear ...

https://en.wikipedia.org/wiki/TFEB

... while the protein is more formally known as serine/threonine-protein kinase B-Raf. The B-Raf protein is involved in sending ... B-Raf is a member of the Raf kinase family of growth signal transduction protein kinases. This protein plays a role in ... Once B-Raf is activated, a conserved protein kinase catalytic core phosphorylates protein substrates by promoting the ... Hanks SK, Hunter T (May 1995). "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain ...

https://en.wikipedia.org/wiki/BRAF_(gene)

Remy I, Michnick SW (Feb 2004). "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt". Mol. ... "Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation ... "Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation". FEBS Lett. ... AKT - the AKT family of proteins AKT2 - the gene for the second member of the AKT family AKT3 - the gene for the third member ...

https://en.wikipedia.org/wiki/AKT1

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https://nn.wikipedia.org/wiki/Kategori:Biokjemispirer

"Protein-Protein Interaction Panel Using Mouse Full-Length cDNAs"، Genome Res.، 11 (10): 1758-65، 2001، doi:10.1101/gr.180101، ... "The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein"، Genes Dev.، 8 (11): ... "A human Id-like helix-loop-helix protein expressed during early development"، Proc. Natl. Acad. Sci. U.S.A.، 89 (4): 1512-6، ... protein dimerization activity. • transmembrane transporter binding. • ‏GO:0001948، ‏GO:0016582 ربط بروتيني. • ‏GO:0001200، ‏GO: ...

https://ar.wikipedia.org/wiki/ID2

Denne sida vart sist endra den 6. november 2016 kl. 09:16 ...

https://nn.m.wikipedia.org/wiki/Kategori:Biokjemispirer

"Structural basis for protein-protein interactions in the 14-3-3 protein family". Proc. Natl. Acad. Sci. U.S.A. 103 (46): 17237- ... These proteins contain a number of known common modification domains, including regions for divalent cation interaction, ... To date, the crystal structures of six classes of these proteins have been resolved and deposited in the public domain.[ ... More than 200 signaling proteins have been reported as 14-3-3 ligands. Elevated amounts of 14-3-3 proteins in cerebrospinal ...

https://en.wikipedia.org/wiki/14-3-3_protein

PorB outer membrane proteins are transmembrane proteins with 8 predicted surface-exposed loops (I-VIII), which vary in length ... proteins are the major proteins found in the outer membrane of Neisseria meningitidis (1); they function as porins, allowing ... Genetics protein I of Neisseria gonorrhoeae: construction of hybrid porins. Proc Natl Acad Sci U S A. 1988;85:6841-5. DOIPubMed ... The porB gene sequence shows VR1-4, which is exclusive of PorB3 protein, and VR2-Eb, VR3-2ab, and VR4-Cc, which are typical of ...

https://wwwnc.cdc.gov/eid/article/14/4/07-0869_article

201 (68%) showed positive immunolabeling of the ERM proteins, 75 (25%) demonstrated weak expression and 20 (7%) no expression. ... 201 (68%) showed positive immunolabeling of the ERM proteins, 75 (25%) demonstrated weak expression and 20 (7%) no expression. ... 201 (68%) showed positive immunolabeling of the ERM proteins, 75 (25%) demonstrated weak expression and 20 (7%) no expression. ... 201 (68%) showed positive immunolabeling of the ERM proteins, 75 (25%) demonstrated weak expression and 20 (7%) no expression. ...

https://jhu.pure.elsevier.com/en/publications/expression-and-prognostic-significance-of-14-3-3%CF%83-and-erm-family--4

Protein Binding, Proto-Oncogene Proteins c-raf/chemistry, Recombinant Proteins/chemistry", ... protein and an unphosphorylated one (ExoS)--in a concentration-dependent manner. Protein crystallography shows that this effect ... protein and an unphosphorylated one (ExoS)--in a concentration-dependent manner. Protein crystallography shows that this effect ... protein and an unphosphorylated one (ExoS)--in a concentration-dependent manner. Protein crystallography shows that this effect ...

https://research.tue.nl/en/publications/molecular-tweezers-modulate-14-3-3-protein-protein-interactions

Chlamydomonas reinhardtii flagellar motility mutant pf-14 fails to assemble radial spokes because of a deficiency for assembly- ... The mutant protein 3 fails to assemble into pf-14 flagella and is maintained within a cytoplasmic pool of unassembled radial ... It is a C-to-T transition near the 5 end of the protein coding region, which changes codon 21 to the ochre termination signal ... 88:80-88). Here, we raise an antiserum to protein 3 and use it to isolate the corresponding structural gene from an expression ...

https://rupress.org/jcb/article/109/1/235/59294/Molecular-cloning-and-sequence-analysis-of-the

N2 - The control of nitrate reductase (NR) activity by reversible protein phosphorylation is a two-stage process: the enzyme is ... AB - The control of nitrate reductase (NR) activity by reversible protein phosphorylation is a two-stage process: the enzyme is ... The control of nitrate reductase (NR) activity by reversible protein phosphorylation is a two-stage process: the enzyme is ... abstract = "The control of nitrate reductase (NR) activity by reversible protein phosphorylation is a two-stage process: the ...

https://experts.illinois.edu/en/publications/post-translational-regulation-of-nitrate-reductase-activity-a-rol

https://wwwnc-origin.cdc.gov/eid/article/14/4/07-0869

View and buy high purity products active at 14-3-3 Proteins from Tocris Bioscience. ... In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are ... and antagonize the activity of proteins that promote cell death and senescence, such as Bad, Bim and Bax. In contrast, 14.3.3σ ... protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine ...

https://www.tocris.com/cell-biology/14-3-3-proteins

Multiple sequence alignments are widely used to predict protein structure, function, and phylogeny, but are uncertain with more ... Influenza A virus (IAV) nonstructural protein 1 (NS1) is a multifunctional virulence factor that interacts with several host ... Proteasomes are vital eukaryotic complexes that recycle unneeded proteins. Here, the authors present the structure of a ... Regain flood adaptation in rice through a 14-3-3 protein OsGF14h Waterlogging tolerance is important in direct seeding rice ...

https://www.nature.com/subjects/evolution/ncomms?error=cookies_not_supported&code=f7be1494-94c6-44ac-85db-b8e1599f6a0d

Dive into the research topics of Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins. ... Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins. ...

https://www.scholars.northwestern.edu/en/publications/electrostatic-interactions-play-a-minor-role-in-the-binding-of-ex/fingerprints/

CJD is caused by a protein called a prion. A prion causes normal proteins to fold abnormally. This affects other proteins ... Spinal tap to test for a protein called 14-3-3. The disease can only be confirmed with a brain biopsy or autopsy. Today, it is ...

https://medlineplus.gov/ency/article/000788.htm

Detect 14-3-3 eta, a marker of research interest related to joint damage and early diagnosis of rheumatoid arthritis. ,, ... Detect 14-3-3 eta, a marker of research interest related to joint damage and early diagnosis of rheumatoid arthritis. ...

https://ltd.aruplab.com/Tests/Pub/3000453

14-3-3 theta Protein, His-tag (Human). 14-3-3 theta Protein, His-tag (Human) ...

https://inveniolife.com/product/bioscience/14-3-3-theta-protein-his-tag-human/

Jelic et al found a positive correlation between levels of tau protein in the cerebrospinal fluid (CSF) and the EEG alpha/delta ... 14] . QEEG alone showed an accuracy of 77% in the whole group and 69% in those with mild AD; regional CBF alone had an accuracy ... The 14-3-3 protein was detected in the cerebrospinal fluid (CSF). The patient died within 5 months of presentation. [46] ... 18, 19] The QEEG of 31 patients with AD was recorded at the early stage of the disease and after a 3-year follow-up. Patients ...

https://www.medscape.com/answers/1138235-192556/what-eeg-findings-are-characteristic-of-atherosclerosis

The vacuole represents a pivotal plant organelle for management of ion homeostasis, storage of proteins and solutes, as well as ... The vacuole represents a pivotal plant organelle for management of ion homeostasis, storage of proteins and solutes, as well as ... Addition of 14-3-3 proteins strongly increased the TPK1 activity in a dose-dependent manner. However, an inverse effect of GRF6 ... Addition of 14-3-3 proteins strongly increased the TPK1 activity in a dose-dependent manner. However, an inverse effect of GRF6 ...

https://tubiblio.ulb.tu-darmstadt.de/47002/

This human protein microarray specificity validated 14-3-3 Sigma antibody (clone CPTC-YWHAE-1) is suitable for use in WB and ... Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a ... Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using 14-3-3 epsilon antibody (clone ... It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to ...

https://www.nsjbio.com/tds/14-3-3-epsilon-antibody-cptc-ywhae-1-protein-microarray-validated-v7362

We also show that one or more TFT proteins physically interact with multiple effectors (AvrXv3, XopE1, XopE2, XopN, XopO, XopQ ... We also show that one or more TFT proteins physically interact with multiple effectors (AvrXv3, XopE1, XopE2, XopN, XopO, XopQ ... We also show that one or more TFT proteins physically interact with multiple effectors (AvrXv3, XopE1, XopE2, XopN, XopO, XopQ ... We also show that one or more TFT proteins physically interact with multiple effectors (AvrXv3, XopE1, XopE2, XopN, XopO, XopQ ...

https://cris.tau.ac.il/en/publications/tomato-14-3-3-proteins-are-required-for-xv3-disease-resistance-an

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76 ... A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76 ...

https://www.immunology.ox.ac.uk/publications/27747?f04778ee-74c0-11ed-8577-061b866677b4

HopQ1 (Hrp outer protein Q), a type III effector secreted by Pseudomonas syringae pv. phaseolicola, is widely conserved among ... In addition, the mutated HopQ1 protein showed reduced stability in planta. These data suggest that the association between host ... IBB PAS Repository is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the ... Phosphorylation of HopQ1, a Type III Effector from Pseudomonas syringae, Creates a Binding Site for Host 14-3-3 Proteins ...

http://eprints.ibb.waw.pl/616/

Ref: Verbeek, DS. et al. Brain 128, 436 (2005); Tapia, J. et al. J. Biol. Chem. 278, 35220 (2003); Jarv, J. et al. Bioorganic Chem. 24, 159 (1996 ...

https://www.bestbiochem.com/catalog-peptide/mbp-4-14-bovine-mbp-3-13-mouse/

Dive into the research topics of Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the ... Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates. ...

https://discovery.dundee.ac.uk/en/publications/evolution-of-signal-multiplexing-by-14-3-3-binding-2r-ohnologue-p/fingerprints/

http://emedicine.medscape.com/article/1138235-overview

We have identified a 14-3-3 homologous gene in A. flavus, artA. In this study we show that artA regulates morphological ... Characterization of the putative 14-3-3 protein, artA, in Aspergillus flavus. ...

http://commons.lib.niu.edu/handle/10843/18579

Other proteins in same PDB: d1ib1e_, d1ib1f_, d1ib1g_, d1ib1h_. *. Domain d1ib1b_: 1ib1 B: [62134]. Other proteins in same PDB ... Other proteins in same PDB: d1ib1e_, d1ib1f_, d1ib1g_, d1ib1h_. *. Domain d1ib1d_: 1ib1 D: [62136]. Other proteins in same PDB ... Lineage for Protein: zeta isoform. *Root: SCOP 1.59 *. Class a: All alpha proteins [46456] (151 folds). ... Timeline for Protein zeta isoform from a.118.7.1: 14-3-3 protein: *Protein zeta isoform from a.118.7.1: 14-3-3 protein first ...

http://scop.berkeley.edu/sunid=48449&ver=1.59

General protein information Go to the top of the page Help Preferred Names. transmembrane protein 102. Names. common beta-chain ... CBAP (Common receptor Beta chain Associating Protein) is a putative transmembrane protein which associates preferentially with ... transmembrane protein 102provided by HGNC. Primary source. HGNC:HGNC:26722 See related. Ensembl:ENSG00000181284 MIM:613936; ... Both variants 1 and 2 encode the same protein.. Source sequence(s). AC113189 Consensus CDS. CCDS11104.1 UniProtKB/Swiss-Prot. ...

https://www.ncbi.nlm.nih.gov/gene/284114

Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human ... Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays ... Age-dependent association between protein expression of the embryonic stem cell marker Cripto-1 and survival of glioblastoma ... ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in ...

https://bora.uib.no/bora-xmlui/handle/1956/934/browse?rpp=20&etal=-1&sort_by=1&type=title&starts_with=0&order=ASC

Among authors: kinoshita k. Protein Sci. 2010 Aug;19(8):1461-8. doi: 10.1002/pro.425. Protein Sci. 2010. PMID: 20509167 Free ... Domain distribution and intrinsic disorder in hubs in the human protein-protein interaction network. Patil A, Kinoshita K, ... Assessing the utility of gene co-expression stability in combination with correlation in the analysis of protein-protein ... Identification of the ligand binding sites on the molecular surface of proteins. Kinoshita K, Nakamura H. Kinoshita K, et al. ...

https://pubmed.ncbi.nlm.nih.gov/?term=Kinoshita+K&cauthor_id=18953027

Calcium Dependent Protein Kinases (CDPKs). CDPKs have a unique structure defined by the presence of a calmodulin-like ... Calcium-Dependent Protein Kinases Regulate Polarized Tip-Growth in Pollen Tubes.. 2009 ... Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.. 2008 ... Enhanced tolerance to oxidative stress in transgenic Arabidopsis plants expressing proteins of unknown function.. 2008 ...

https://www.unr.edu/bmb/directory/harper-jeff

Monoclonal Antibody for studying 14-3-3 epsilon/14-3-3 gamma/14-3-3 beta/alpha/14-3-3 tau/14-3-3 eta/14-3-3 sigma/14-3-3 zeta/ ... Cited in 3 publications. Validated for Western Blotting. Highly specific and rigorously validated in-house, 14-3-3 (pan) (E9S9M ... Pathways & Proteins. Explore pathways + proteins related to this product.. Select Your Pathway/Protein. Actin Dynamics. ... Blue Prestained Protein Marker, Broad Range (11-250 kDa): (#59329).. *Blotting Membrane and Paper: (#12369) This protocol has ...

https://www.cellsignal.com/products/primary-antibodies/14-3-3-pan-e9s9m-rabbit-mab/95422?N=0+782416468+4294956287&fromPage=plp

Association of the Presence of Anti- Carbamylated Protein Antibodies in Early Arthritis with a Poorer Clinical and Radiologic ... carbamylated protein) Ab, enhances the diagnosis of established or early RA (especially in individuals seronegative for RF and ... Decrease in 14-3-3 eta and/or Anti-Sa Ab with treatment is associated with less radiographic progression. The presence of Anti- ... 14-3-3 eta protein; Anti-CEP1 (citrullinated alpha-enolase 1) Ab; Anti-Sa (citrullinated vimentin) Ab; Anti-CarP (carbamylated ...

https://www.labcorp.com/tests/520305/seroneg-radx4-profile

This article is the author's final published version in Cancers, Volume 14, Issue 15, July 2022, Article number 3562. (jefferson.edu)
Sam H. Gellman (University of Wisconsin - Madison) presents "Foldamers: Extrapolating from Proteins," on Friday, January 28, 2022 at 3:30pm on Zoom. (carleton.edu)
Sept. 2, 2022, 3:28 p.m. (rosalind.info)
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July 19, 2022, 3:07 p.m. (rosalind.info)
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ACAAI 2022 Peanut-Allergic Toddlers Also Benefit From Oral Immunotherapy With Palforzia New research findings show that an FDA-approved oral immunotherapy for older children and adolescents safely increased peanut protein tolerance in peanut-allergic children aged 1-3 years. (medscape.com)

These proteins contain a number of known common modification domains, including regions for divalent cation interaction, phosphorylation & acetylation, and proteolytic cleavage, among others established and predicted. (wikipedia.org)
Phosphorylation of Cdc25C by CDS1 and CHEK1 creates a binding site for the 14-3-3 family of phosphoserine binding proteins. (wikipedia.org)
The control of nitrate reductase (NR) activity by reversible protein phosphorylation is a two-stage process: the enzyme is reversibly phosphorylated, and the phosphorylated form then binds an inhibitor protein. (illinois.edu)
Recent results indicate that the phosphorylation reaction is Ca 2+ -dependent and that the inhibitor is a member of the 14-3-3 family of proteins. (illinois.edu)
14.3.3 proteins are regulated by post-translational modifications such as phosphorylation, and by the binding of cofactors. (tocris.com)
Phosphorylation sites on 14.3.3 proteins are not conserved between family members and thus enable selective isoform regulation. (tocris.com)
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into the core regulatory pathways that are crucial for normal growth and development. (tocris.com)
Co-localization of wild-type TPK1, but not the TPK1-S42A mutant, indicates that phosphorylation of the 14-3-3 binding motif of TPK1 represents a prerequisite for interaction. (tu-darmstadt.de)
Moreover, mass spectrometric (LC-MS-MS/MS) analyses detected specific phosphorylation of the canonical 14-3-3 binding site (RSXpSXP, pS denotes phosphoserine) located in the N-terminal region of HopQ1. (waw.pl)
The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
A particular focus is made on the role of membrane nanodomains, reactive oxygen species and protein phosphorylation. (inra.fr)
We demonstrate that UVB irradiation increased phosphorylation of AKT and induced nuclear translocation of 14-3-3σ and TC45. (oncotarget.com)
Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. (genscript.com)
The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. (genscript.com)
Our protein-domain microarray technology facilitates the identification of proteins that interact with motifs that carry phosphorylation, methylation and acetylation modifications. (mdanderson.org)
The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by CaMK. (abcam.com)
The RRAD protein exhibits N- and C-terminal extensions that create additional phosphorylation sites for binding proteins, such as calmodulin and 14-3-3 proteins. (ithanet.eu)
They are also involved in the regulation of tau phosphorylation and amyloid precursor protein (APP) processing. (bmj.com)
Tumor promoters accentuate phosphorylation of PO: Evidence for the presence of protein kinase C in purified PNS myelin. (cdc.gov)

Eukaryotes can tolerate the loss of a single 14-3-3 gene if multiple genes are expressed, but deletion of all 14-3-3s (as experimentally determined in yeast) results in death. (wikipedia.org)
The presence of large gene families of 14-3-3 proteins in the Viridiplantae kingdom reflects their essential role in plant physiology. (wikipedia.org)
The porB gene sequence shows VR1-4, which is exclusive of PorB3 protein, and VR2-Eb, VR3-2ab, and VR4-Cc, which are typical of PorB2 (GenBank accession no. (cdc.gov)
The 5′ region of 14-3-3σ (stratifin) is hypomethylated in pancreatic adenocarcinomas and is associated with gene overexpression. (elsevier.com)
Molecular cloning and sequence analysis of the Chlamydomonas gene coding for radial spoke protein 3: flagellar mutation pf-14 is an ochre allele. (rupress.org)
Here, we raise an antiserum to protein 3 and use it to isolate the corresponding structural gene from an expression library. (rupress.org)
Southern blot analysis indicates that the gene is single copy and has not undergone major rearrangement in mutant pf-14 cells. (rupress.org)
The unphosphorylated isoform of radial spoke protein 3 is identified, and the sequence similarities between intervening sequences of the radial spoke protein 3 gene and a conserved intervening sequence of the two Chlamydomonas beta-tubulin genes (Youngblom, J., J. A. Schloss, and C. D. Silflow. (rupress.org)
The YWHAE gene which encodes 14-3-3 epsilon has also been identified as a possible susceptibility gene for schizophrenia. (nsjbio.com)
We have identified a 14-3-3 homologous gene in A. flavus, artA. (niu.edu)
Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene. (wikipedia.org)
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. (wikipedia.org)
14-3-3 protein zeta/delta ( 14-3-3ζ ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. (wikidoc.org)
[1] [2] The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways. (wikidoc.org)
[9] The YWHAZ gene encodes two transcript variants which differ in the 5' UTR but produce the same protein. (wikidoc.org)
The 14-3-3 protein zeta/delta (14-3-3ζ) is a protein (in humans encoded by the YWHAZ gene on chromosome 8) with an important apoptotic constituents. (wikidoc.org)
Transthyretin (TTR) variants are associated with hereditary amyloidoses, clinically termed familial amyloidotic polyneuropathy (FAP) or cardiomyopathy when point mutations in the TTR gene result in protein deposition in the peripheral nervous system (PNS) or heart, respectively [ 1 ]. (biomedcentral.com)
The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. (antibodies-online.com)
The recently discovered TPR gene family encodes a diverse group of proteins that function in mitosis, transcription, splicing, protein import and neurogenesis. (embl.de)
Identify the precise type of prion disease (sporadic, familial, or acquired) by examining the prion protein and the prion protein gene, once the diagnosis of prion disease has been established. (case.edu)
Search for the presence of mutation in the prion protein gene and determine the polymorphism at codon 129 and at other codons. (case.edu)
Regulation of Gene Expression by NO/cGMP/cGMP-dependent Protein Kinases. (ucsd.edu)
Recently several reports have cleotide (designated as 0/10 bp) in the pro- focused on the association between the moter region of the gene at position -323 factor VII of the cascade coagulation and [ 13,14 ]. (who.int)
The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
Hypertrophic cardiomyopathy is inherited as an autosomal dominant trait and is attributed to mutations in one of a number of genes that encode for one of the sarcomere proteins including beta-cardiac myosin heavy chain (the first gene identified), cardiac actin, cardiac troponin T, alpha-tropomyosin, cardiac troponin I, cardiac myosin-binding protein C, and the myosin light chains. (bionity.com)
Approximately 45% of these mutations occur in the β myosin heavy chain gene on chromosome 14 q11.2-3) while approximately 35% involve the cardiac myosin binding protein C gene. (bionity.com)
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. (nih.gov)
Eitzen, G.A., V.I. Titorenko, J.J. Smith, M. Veenhuis, R.K. Szilard, R.A. Rachubinski(1996) The Yarrowia lipolytica gene PAY5 encodes a peroxisomal integral membrane protein homologous to the mammalian peroxisome assembly factor PAF-1. (concordia.ca)
COVID-19 can be diagnosed by detection of RNA gene targets (e.g., spike protein (S), an envelope protein (E), nucleocapsid protein (N), RNA-dependent RNA polymerase enzyme, and ORF1 gene) (4-6) either by nucleic acid amplification testing or detection of virus-specific proteins by antigen testing (7,8). (who.int)

Certain carbohydrates, free of proteins, such as pneumococcal polysaccharides and highly crosslinked dextran, have been demonstrated to induce allergic reactions in man, and some carbohydrates (e.g., inulin) can function as haptens or as the antigenic part of glycoproteins. (vin.com)

The World manifestations (7,11) , and patients show a wide range of Health Organization (WHO) declared the outbreak a clinical symptoms from mild and asymptomatic to very public health emergency of international concern on 30 severe including viral pneumonia, respiratory failure and January 2020 (3) . (who.int)

EACH: 85 calories, 1 g protein, 14 g carbohydrate, 3 g total fat (1 g saturated), 0 mg cholesterol, 120 mg sodium. (astray.com)
For protein bars that are good for a snack, look for fewer than 200 calories. (wboy.com)
Per serving: 264 calories, 14 g total fat (2 g saturated fat), 3 g carbohydrate, 30 g protein, 2 g dietary fiber, 386 mg sodium. (pioneerthinking.com)

11 However, in cases where a dietary carbohydrate is suspected as an allergen, it is more likely that there is a protein allergen within the carbohydrate source than there is the existence of a true hypersensitivity to the carbohydrate molecules. (vin.com)
Maize zeins, which are 20 to 23 kDa proteins, have been detected in hydrolysed casein formulae when corn starch is used as the carbohydrate source. (vin.com)
5 Thus, the carbohydrate and lipid ingredients in hydrolysed protein diets may be an important source of protein allergens since they are not subjected to enzymatic hydrolysis and should be considered when evaluating diets. (vin.com)

Western blot testing of human 1) HEK293, 2) PC-3 and 3) A431 lysate with 14-3-3 epsilon antibody. (nsjbio.com)
IHC staining of FFPE human testis with 14-3-3 epsilon antibody (clone CPTC-YWHAE-1). (nsjbio.com)
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using 14-3-3 epsilon antibody (clone CPTC-YWHAE-1). (nsjbio.com)
Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. (nsjbio.com)
SDS-PAGE analysis of purified, BSA-free 14-3-3 epsilon antibody (clone ACP5/2336R) as confirmation of integrity and purity. (nsjbio.com)
This 14-3-3 epsilon antibody is available for research use only. (nsjbio.com)
Titration of the 14-3-3 epsilon antibody may be required due to differences in protocols and secondary/substrate sensitivity. (nsjbio.com)
Full length recombinant human protein was used as the immunogen for the 14-3-3 epsilon antibody. (nsjbio.com)
Store the 14-3-3 epsilon antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). (nsjbio.com)
Balb/c mouse monoclonal antibody against ALR protein was prepared in order to detect the ALR protein in HCC by Western blotting and immunohistochemistry. (dovepress.com)
Lateral flow assay and ELISA techniques gave consistent results for IgG/IgM antibody measurements towards spike and nucleocapsid proteins, suggesting that both methods can be used to detect COVID-19 where access to molecular test kits is difficult. (who.int)

Binding of 14-3-3 has little effect on Cdc25C activity, and it is believed that 14-3-3 regulates Cdc25C by sequestering it to the cytoplasm, thereby preventing the interactions with CycB-Cdk1 that are localized to the nucleus at the G2/M transition. (wikipedia.org)
[4] [5] For the most part,14-3-3ζ negatively regulates apoptosis by binding and sequestering BAD and BAX in the cytoplasm, effectively preventing activation of proapoptotic Bcl-2 and Bcl-XL, as well as by preventing NOXA from inhibiting antiapoptotic MCL1 . (wikidoc.org)
In addition to cell survival, 14-3-3ζ regulates cell cycle progression through various ligands and processes. (wikidoc.org)
Pdc regulates the G-protein cascade by competing with the α-subunit of G-protein (Gα) for binding to the βγ-dimer (Gβγ)of transducin, retinal-specific G-protein. (biologists.com)
Substrates targeted by TC-PTP include Janus kinase 1 (JAK1), JAK3, signal transducer and activator of transcription 1 (STAT1), STAT3, and STAT5, which suggests that TC-PTP negatively regulates the JAK/STAT signaling, an important mechanism for the transmission of extracellular signals that can regulate proliferation, differentiation, and apoptosis [ 3 , 4 ]. (oncotarget.com)
Structure-Function Analysis of PPP1R3D, a Protein Phosphatase 1 Targeting Subunit, Reveals a Binding Motif for 14-3-3 Proteins which Regulates its Glycogenic Properties. (genscript.com)

Huber, SC, Bachmann, M & Huber, JL 1996, ' Post-translational regulation of nitrate reductase activity: A role for Ca 2+ and 14-3-3 proteins ', Trends in Plant Science , vol. 1, no. 12, pp. 432-438. (illinois.edu)
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism , protein trafficking, signal transduction , apoptosis and cell cycle regulation. (tocris.com)
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. (tocris.com)
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. (nsjbio.com)
It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. (nsjbio.com)
The 14-3-3 phospho-binding proteins with scaffolding activity play central roles in the regulation of enzymes and signaling complexes in eukaryotes. (tau.ac.il)
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (nih.gov)
It is revealed that this type of naphthyl-sulfo (NS) molecule directly targets the substrates but not PRMTs for the observed inhibition, which provides a new way for chemical regulation of protein arginine methylation. (semanticscholar.org)
Cloning and direct G-protein regulation of phospholipase D from tobacco. (mpg.de)
The alpha-subunit of a heterotrimeric G-protein from tobacco, NtGP alpha 1, functions in K+ channel regulation in mesophyll cells. (mpg.de)
Regulation of plant potassium channels by G proteins and 14-3-3 proteins. (mpg.de)
Regulation of cell cycle control and other cellular pathways by 14-3-3 proteins. (actrec.gov.in)
Most functions in cells are performed by large protein complexes and the regulation of complex formation is critical to cell homeostasis. (actrec.gov.in)
Regulation of centrosome duplication by 14-3-3 proteins. (actrec.gov.in)
These processes are linked to the regulation of aquaporins, membrane channel proteins that facilitate the transport of water across cell membranes. (inra.fr)
Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding. (embl.de)
We have identified a number of genes and transcription factors regulated by nitric oxide (NO) and cGMP through activation of cGMP-dependent protein kinases (PKGs), and have characterized different mechanisms of transcriptional regulation by PKGs. (ucsd.edu)
Deletion of the EFF-1A endodomain noticeably affects the timing of hypodermal cell fusions in vivo, and the two 14-3-3 proteins in C. elegans, PAR-5 and FTT-2, may regulate either localization or fusion-inducing activity of EFF-0, highlighting the necessity of tight fusogen regulation for proper development. (semanticscholar.org)
Zhu J, Reynet C, Caldwell JS, Kahn CR, Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. (ithanet.eu)
Yang T, Colecraft HM, Regulation of voltage-dependent calcium channels by RGK proteins. (ithanet.eu)

PKCI (protein kinase C inhibitor), was originally purified from bovine brain. (ucl.ac.uk)
The drug is already known as a specific inhibitor of nuclear import mediated by Importin alpha/beta - thereby inhibiting replication of RNA viruses [ 3 ]. (thieme-connect.de)
These possibilities were addressed by measuring steady-state concentrations of mRNA encoding PGF(2α) receptor and two inhibitors of PKC, protein kinase C inhibitor-1 (PKCI-1) and kinase C inhibitor protein-1 (KCIP-1, brain 14-3-3 protein), in corpora lutea collected from ewes on days 4, 10 and 15 of the oestrous cycle (n = 5 per day) and day 15 of pregnancy (n = 7). (elsevier.com)
TPR-containing proteins include the anaphase promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67 phox, hsp90-binding immunophilins, transcription factors, the PKR protein kinase inhibitor, and peroxisomal and mitochondrial import proteins. (embl.de)

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts"، J Biol Chem ، 269 (3): 2139-45، فبراير 1994، PMID 8294468 . (wikipedia.org)

Dec. 2, 2021, 3:27 p.m. (rosalind.info)
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Oct. 3, 2021, 7:12 a.m. (rosalind.info)
Aug. 23, 2021, 3:14 p.m. (rosalind.info)
May 14, 2021, 3:48 p.m. (rosalind.info)
A new SARS-CoV-2 variant, lineage B.1.1.529, was first detected in Botswana on November 11, 2021, and South Africa on November 14, 2021. (cdc.gov)

We now show that lysine-specific molecular tweezers bind to a 14-3-3 adapter protein and modulate its interaction with partner proteins. (tue.nl)
The physical interaction between HopQ1 and 14-3-3a was confirmed in planta using FRET-FLIM techniques. (waw.pl)
PiSite: a database of protein interaction sites using multiple binding states in the PDB. (nih.gov)
Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)
Several additional interacting proteins are known, but not always is there an understanding of the specific function and relevance of this interaction. (wikipedia.org)
Therefore regions conserved between 14-3-3 isoforms must contain the major PKC interaction sites, and variable 14-3-3 sites must also influence potency of inhibition. (ucl.ac.uk)
This work enabled the primary 14-3-3 interaction site on PKC to be narrowed down to the conserved cysteine-rich region (C1). (ucl.ac.uk)
[4] Furthermore, 14-3-3ζ may regulate glucose receptor trafficking in response to insulin levels through its interaction with IRS1 . (wikidoc.org)
Tian X, Zhu M, Li L, Wu C . Identifying protein-protein interaction in Drosophila adult heads by Tandem Affinity Purification (TAP). (academictree.org)
Immunological techniques and high-resolution FRET analysis were employed to investigate the in vivo colocalization and interaction of phosducin(Pdc) with the βγ-subunits of G-protein (Gβγ) in the ciliate Blepharisma japonicum . (biologists.com)

14-3-3 binds to peptides. (wikipedia.org)
In this article, we review the recent developments in the concept and methods for the determination of the dynamic structures of flexible peptides and proteins. (frontiersin.org)
Thus, ensemble-averaged quantities are usually obtained from measurements while studying conformational dynamics of multistate proteins, IDPs, or flexible peptides. (frontiersin.org)
The most complete information about the structure and conformational dynamics of proteins and peptides is provided by NMR ( Sekhar and Kay, 2019 ). (frontiersin.org)

14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. (wikipedia.org)
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the target that prevent molecular interactions and/or modulate the accessibility of a target protein to modifying enzymes such as kinases , Phosphatases and proteases . (tocris.com)
Members of the 14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions, such as Raf kinases , and antagonize the activity of proteins that promote cell death and senescence, such as Bad, Bim and Bax . (tocris.com)
Calcium Dependent Protein Kinases (CDPKs). (unr.edu)
Protein Kinase C (PKC) is a family of serine/threonine kinases. (ucl.ac.uk)
In particular, 14-3-3ζ is a key player in regulating cell survival and interacts with many apoptotic proteins, including Raf kinases , BAX , BAD , NOXA , and caspase-2 . (wikidoc.org)
[11] Also, 14-3-3ζ can negatively regulate the G2-M phase checkpoint by binding and sequestering the cyclin-dependent kinases to the cytoplasm, thus inhibiting their activity. (wikidoc.org)
We are also interested in the cross-talk between Ras and Rho and other signaling pathways, and are examining mechanisms whereby cAMP- and cGMP-dependent protein kinases regulate the activities of these proteins. (ucsd.edu)

The authors indicate that the serum based 14-3-η marker is additive to the armamentarium of existing tools available to clinicians, and that there is adequate clinical evidence to support its clinical benefits in the management of patients diagnosed with rheumatoid arthritis (RA). (wikipedia.org)
A 249 full-length recombinant human protein microarray was used for profiling the serum samples. (jefferson.edu)
METHODS: This multi-centre randomised double-blind placebo-controlled trial studied retreatment with oral ciprofloxacin 500mg or matched placebo twice daily for 7 days in patients with GOLD stage II - IV COPD with persistent symptoms and/or serum C-reactive protein (CRP) ≥8mg/L initiated 14 (+/- 3) days after an index COPD exacerbation. (imperial.ac.uk)
Whether whey protein supplementation based on standard enteral nutrition preparation can improve serum albumin level and reduce the incidence of hypoproteinemia in patients with severe acute neurological disease has not been proved. (centerwatch.com)
According to the body weight of the patients, different enteral nutritional preparations and dose adjustments were selected to ensure that the calorie and protein intake of the two groups of patients met the above nutritional treatment requirements.Primary endpoint: serum albumin level at 14 days of enteral nutrition. (centerwatch.com)
This Human hs-CRP ELISA Kit was designed for the quantitative measurement of Human hs-CRP protein in serum, plasma, cell culture supernates, tissue homogenates. (cusabio.com)
ABSTRACT The study aimed to determine whether serum C-reactive protein (CRP) levels can be used to identify when antibiotics can safely be discontinued in cases of suspected neonatal septicaemia. (who.int)

Detect 14-3-3 eta, a marker of research interest related to joint damage and early diagnosis of rheumatoid arthritis. (aruplab.com)
However this defence system is a double-edged sword because failure to resolve inflammation can cause chronic inflammatory diseases and/or autoimmune disorders, such as rheumatoid arthritis and systemic lupus erythematosus 1-3 . (justia.com)

Protein crystallography shows that this effect arises from the binding of the tweezers to a single surface-exposed lysine (Lys214) of the 14-3-3 protein in the proximity of its central channel, which normally binds the partner proteins. (tue.nl)
In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. (wikipedia.org)
[12] Since 14-3-3ζ is predominantly found in the cytoplasm and binds many nuclear proteins, it likely prevents nuclear import by blocking the nuclear localization signal of target proteins. (wikidoc.org)
The active, hypophosphorylated form of the protein binds transcription factor E2F1. (nih.gov)

2016. Palmitoylation of desmoglein 2 is a regulator of assembly dynamics and protein turnover. (unmc.edu)
According to the nutritional treatment requirements of critically ill patients in the Asia-Pacific region in 2016, patients with severe acute stress were given energy demand for 25~30kcal/kg/d, protein demand for 1.2~2g/kg/d and other standardized clinical treatments. (centerwatch.com)

The most likely origin of the porB2/3 hybrid (4, Eb, 2ab, Cc) is the acquisition of DNA that encodes a VR1-4 sequence by a meningococcus with a porB2-99 allelic variant. (cdc.gov)
We obtained a mutant rela (regulator of leaf angle) with reduced leaf angle in rice by EMS mutagenesis, and map-based cloning revealed that OsRELA encodes a protein of unknown function. (frontiersin.org)
In addition to the four structural proteins, the SARS-CoV2 genome encodes 16 non-structural proteins (NSPs) essential for virus replication but also to elicit the immune response and represent targets to develop future prophylactic and therapeutic approaches against COVID-19 (9) . (anaspec.com)

A prion causes normal proteins to fold abnormally. (medlineplus.gov)
Many proteins can fold into well-defined conformations. (frontiersin.org)
The most abundant mammalian brain 14-3-3 isoforms inhibited PKC, within a three-fold range. (ucl.ac.uk)
Multiple-TPR motif proteins would fold into a right-handed super-helical structure with a continuous helical groove suitable for the recognition of target proteins, hence defining a novel mechanism for protein recognition. (embl.de)
It is common knowledge within molecular biology that proteins fold into their native state. (lesswrong.com)
Nature is clever and developed a way to help proteins fold into their native state. (lesswrong.com)
A chaperone surrounds an unfolded protein to protect it from outside influences to help the protein to fold into its native state. (lesswrong.com)
A chaperone doesn't need to know the native state of a protein to help the protein fold into that state. (lesswrong.com)
The machine learning algorithm tries to figure out the best way for the protein to fold while the chaperone just lets the protein find this way by itself. (lesswrong.com)
In the bowl containing the tofu and chocolate protein mix, gently fold in the egg white mixture. (prevention.com)
3. Fold the egg mixture into the flour mixture until combined. (browneyedbaker.com)
Considerable computational and experimental efforts over the past three decades have been devoted to learning about or predicting how proteins fold. (biomedcentral.com)
The canonical histone proteins contain a histone-fold motif, made up of three α helices with one central helix connected to two other small helices through two loops, along with flexible N -terminal tails. (ukdiss.com)
The histone-fold motifs of distinct histone proteins complement each other to form a handshake motif leading to assembly of histone heterodimers (H2A/H2B and H3/H4). (ukdiss.com)

The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. (embl.de)
Two protein surfaces are generated: the inner concave surface is contributed to mainly by residue on helices A, and the other surface presents residues from both helices A and B. (embl.de)
The absolute contact order, denoted as Abs_CO, of a protein is defined as the average number of residues separating the contacts inside the protein (where two sequentially adjacent residues are separated by one residue). (biomedcentral.com)
The relative contact order, or simply the contact order, is denoted as CO. Essentially, CO measures the average sequence separation between contacting residues in the native state of a protein normalized by the protein length, and intuitively, when the portion of interacting atoms which are far away in the protein sequence grows, CO increases. (biomedcentral.com)
Maximum limits for pesticide residues -- v. 14. (who.int)

Raf-1 Bad - see Bcl-2 Bax Cdc25 Akt SOS1 - see RSK YWHAB - "14-3-3 beta" YWHAE - "14-3-3 epsilon" YWHAG - "14-3-3 gamma" YWHAH - "14-3-3 eta" YWHAQ - "14-3-3 tau" YWHAZ - "14-3-3 zeta" SFN or YWHAS - "14-3-3 sigma" (Stratifin) The 14-3-3 proteins alpha and delta (YWHAA and YWHAD) are phosphorylated forms of YWHAB and YWHAZ, respectively. (wikipedia.org)

A 430-aa recombinant protein (designated as NM) derived from the minor ampullate spidroin of Araneus ventricosus was expressed in E. coli , and the recombinant proteins were mainly present in insoluble fraction as IBs. (researchsquare.com)

There are common recognition motifs for 14-3-3 proteins that contain a phosphorylated serine or threonine residue, although binding to non-phosphorylated ligands has also been reported. (wikipedia.org)
The tetratricopeptide repeat (TPR) is a degenerate 34 amino acid sequence identified in a wide variety of proteins, present in tandem arrays of 3-16 motifs, which form scaffolds to mediate protein-protein interactions and often the assembly of multiprotein complexes. (embl.de)
The Minimotif Miner Web site contains information on several hundred short functional motifs in a single database, and allows the user to search protein queries for the presence of these motifs. (semanticscholar.org)
Scoring based on evolutionary conservation, protein surface prediction, and motif frequency can be used in conjunction with other motif programs and the known biology of the query to reduce false‐positive predictions and select short motifs for experimental pursuit. (semanticscholar.org)
The role of the P2X7R C terminus in regards to receptor function is discussed, the specific domains and motifs found therein are described and compared with others proteins to discover predicted domains or sites of PTM are compared. (semanticscholar.org)
A motif database comprising 312 unique motifs and a web-based tool for identifying motifs in proteins are constructed and functional motifs predicted by MnM are validated by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifsIn EFF-1. (semanticscholar.org)
ELM, the Eukaryotic Linear Motif server at http://elm.eu.org/, is a new bioinformatics resource for investigating candidate short non-globular functional motifs in eukaryosis proteins, aiming to fill the void in bio informatics tools. (semanticscholar.org)

Seven genes encode seven distinct 14-3-3 proteins in most mammals (See Human genes below) and 13-15 genes in many higher plants, though typically in fungi they are present only in pairs. (wikipedia.org)
The p85α subunit of phosphatidyl inositol 3 kinase (PIK3R1) and the regulatory subunit 3 of protein phosphatase 1 (PPP1R3) were selected as candidate genes because both encode key proteins involved in insulin signalling and because polymorphisms in these genes have been previously implicated in insulin resistance or type II diabetes. (bmj.com)
and major capsid protein and minor structural protein genes, complete cds. (cdc.gov)

We are now expanding this facility to not only include state-of-the-art protein domain microarrays, but also to allow the further characterization of these protein-protein interactions in cells. (mdanderson.org)

Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can interact with two target proteins simultaneously. (tocris.com)
In addition, 14.3.3 proteins can act as a scaffold molecule to anchor target proteins within close proximity of one another. (tocris.com)

citation needed] 14-3-3 proteins are structurally similar to the Tetratrico Peptide Repeat (TPR) superfamily, which generally have 9 or 10 alpha helices, and usually form homo- and/or hetero-dimer interactions along their amino-termini helices. (wikipedia.org)
Supramolecular chemistry has recently emerged as a promising way to modulate protein functions, but devising molecules that will interact with a protein in the desired manner is difficult as many competing interactions exist in a biological environment (with solvents, salts or different sites for the target biomolecule). (tue.nl)
A combination of structural analysis and computer simulations provides rules for the tweezers' binding preferences, thus allowing us to predict their influence on this type of protein-protein interactions. (tue.nl)
A potential role for protein O-fucosylation during pollen-pistil interactions. (unr.edu)
In addition to these primary interactions, the target protein can also bind outside the groove via secondary interactions. (wikidoc.org)
This adds further support to the fact that the cylinder surface of GFP is rather versatile and can employ various polar and non-polar patches in protein-protein interactions. (rcsb.org)
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. (embl.de)
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (genscript.com)
This high-throughput approach allows for the rapid identification of protein-protein interactions in vitro. (mdanderson.org)
In addition, we will provide the instrumentation and know-how to determine the strength of these protein-protein interactions. (mdanderson.org)

More than 200 signaling proteins have been reported as 14-3-3 ligands. (wikipedia.org)
The second problem we work on in the laboratory is to elucidate the mechanisms by which the 14-3-3 protein family bind to and dissociate from their protein ligands thereby affecting ligand function. (actrec.gov.in)
As part of these studies we wish to determine the molecular basis for specific complex formation between 14-3-3 proteins and their ligands and elucidate their role in the centrosome duplication pathway. (actrec.gov.in)
These studies have been extended to identify specific ligands for individual 14-3-3 isoforms to determine how individual family members regulate different cellular pathways. (actrec.gov.in)

Acana Freeze-Dried Patties High Protein Free-Run Turkey Recipe for Dogs 14 oz. (carealotpets.com)
Easily add your favorite protein to this garlic and parmesan spaghetti squash recipe! (artfrommytable.com)

In plants, 14-3-3 isoforms are required for disease resistance and key targets of pathogen effectors. (tau.ac.il)
The 14-3-3 family consists of highly conserved protein isoforms, with wide range of putative functions. (ucl.ac.uk)
Individual PKC isoforms were inhibited by mixed brain 14-3-3 isoforms, with varying potency. (ucl.ac.uk)

Here we show that AtTPK1 (KCO1), a vacuolar membrane localized K(+) channel of the TPK family, interacts with 14-3-3 proteins (general regulating factors, GRFs). (tu-darmstadt.de)
CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. (nih.gov)
It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)
Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. (wikipedia.org)
Plastidial Thioredoxin z Interacts with Two Fructokinase-Like Proteins in a Thiol-Dependent Manner: Evidence for an Essential Role in Chloroplast Development in Arabidopsis and Nicotiana benthamiana. (mpg.de)

Some of the lower-protein Clif snack bars are great for an afternoon snack, but if you are using a protein bar to fuel your workout or give you a burst of energy on a long hike, you'll need to make sure your protein bar contains at least 5 grams of protein. (wboy.com)
Some Clif protein bars contain as much as 15 grams of protein. (wboy.com)
Protein bars with 3-6 grams of protein will support consistent blood sugar levels and maybe more satisfying than low fiber options. (wboy.com)
The recommended daily amount of protein is 46 grams for women and 56 grams for men. (cdc.gov)
Toss'ables have 14 grams of plant-based protein per 3 oz. serving and are packaged in a convenient pouch. (pricechopper.com)
This frontier-inspired protein flapjack in a cup is made with 100% whole grains, semisweet chocolate chips and real maple syrup, and 12 grams of protein. (dillons.com)

After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
Therefore, in colon cancer cells, GSDME mediates lobaplatin-induced pyroptosis downstream of the ROS/JNK/Bax-mitochondrial apoptotic pathway and caspase-3/-9 activation. (nature.com)
For instance, 14-3-3ζ controls cellular senescence by complexing with BIS to chaperone protein folding of STAT3 and activate the signaling pathway. (wikidoc.org)
The 14-3-3 family participates in almost every signaling pathway present in mammalian cells which is why we think of them as the answer to the ultimate question of the life, the universe and everything. (actrec.gov.in)
The phototransduction cascade in vertebrate photoreceptor cells is a well-studied G-protein-mediated signaling pathway. (biologists.com)
Mechanistically, circPAK1 enhanced HCC progression by inactivating the Hippo signaling pathway, and this kind of inactivation is based on its competitively binding of 14-3-3 ζ with YAP, which weakens the recruitment and cytoplasmic fixation of 14-3-3 ζ to YAP, thus promoting YAP nucleus localization. (biomedcentral.com)
CircPAK1 exerts its oncogenic function by competitively binding 14-3-3 ζ with YAP, thus promoting YAP nucleus localization, leading to the inactivation of a Hippo signaling pathway. (biomedcentral.com)
These results define binding to 14-3-3 proteins as an additional pathway in the control of the glycogenic properties of PPP1R3D (R6). (genscript.com)
Here, we targeted phosphatidyl inositol 3 kinase (PI3-K) and protein phosphatase 1 (PP1) because they are key components of the insulin signalling pathway. (bmj.com)
An analysis of trafficking of peroxisomal proteins in vivo suggests the existence of a multistep peroxisome assembly pathway in Y. lipolytica. (concordia.ca)
This pathway operates by conversion of peroxisomal subforms in the direction P1, P2→P3→P4→P5→P6 and involves the import of various peroxisomal proteins into distinct vesicular intermediates. (concordia.ca)

All N. meningitidis strains received in the Spanish Reference Laboratory for Neisseria are routinely serotyped by whole-cell ELISA ( 5 ) with a set of monoclonal antibodies (MAbs) provided by the National Institute for Biological Standards and Control (South Mimms, UK) that includes the following serotypes: 1 (MN3C6B), 2a (5D4-5), 2b (MN2C3B), 4 (5DC4C8G8), 14 (MN5C8C), 15 (8B5-5G9), and 21 (6B11F2B5). (cdc.gov)
Association of the Presence of Anti- Carbamylated Protein Antibodies in Early Arthritis with a Poorer Clinical and Radiologic Outcome. (labcorp.com)
Anti-Hu antibodies may alter the production of these proteins, which are essential for the development, maturation, and maintenance of the vertebrate nervous system. (medscape.com)
In one report, a subset of patients with limbic encephalitis associated with a systemic neoplasm previously attributed to antibodies against voltage gated potassium channel antibodies actually recognize LGI1 protein complex epitopes and do not represent a channelopathy. (medscape.com)
Abcam: antibodies, proteins, kits. (abcam.com)
Chicken 14-3-3 protein gamma (YWHAG) ELISA Kit is manufactured by highest quality antibodies and plates to provide you with excellent and reproducible results in your work. (az-biotech.com)
Aitchison, J.D., R.K. Szilard, W.M. Nuttley, R.A. Rachubinski(1992) Antibodies directed against a yeast carboxyl-terminal peroxisomal targeting signal specifically recognize peroxisomal proteins from various yeasts. (concordia.ca)

In addition, we determined whether TFT proteins interact with the repertoire of X. euvesicatoria type III secretion effector proteins, including AvrXv3, the elicitor of Xv3 resistance. (tau.ac.il)
HopQ1 (Hrp outer protein Q), a type III effector secreted by Pseudomonas syringae pv. (waw.pl)
These data suggest that the association between host 14-3-3 proteins and HopQ1 is important for modulating the properties of this bacterial effector. (waw.pl)
The T6SS resembles an inverted T4 bacteriophage tail and is used to deliver toxic effector proteins into neighboring cells. (bepress.com)
Through a proteomics approach, we have identified novel Rho effector proteins, and defined their functions in cancer cells. (ucsd.edu)

The SARS-CoV-2 genome is known to encode at least 29 proteins, all of which are of great interest to researchers investigating the virus life cycle, host cell entry, and immune system stimulation, and all for the purpose of seeking out targets for treatments and vaccines. (anaspec.com)

SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Structural proteins are essential in many steps of the infection, they are implied in viral genome production, replication, virion-receptor attachment, viron and viroporin formation that will promote virus entry into the host, proliferation and spread of the infection. (anaspec.com)

Noncanonical amino acid labeling in vivo to visualize and affinity purify newly synthesized proteins in larval zebrafish. (mpg.de)
Even in vivo protein folding is a hard problem. (lesswrong.com)

3 g Net Carbs. (yourlighterside.com)
3 g Carbs. (yourlighterside.com)
Are you trying to cut carbs, red meat and increase your plant protein intake? (pricechopper.com)

This hypothesis is based on our previous findings that different junctional proteins confer distinct adhesive characteristics on epithelial cells, and that formation of various cell junctions initiates cell adhesion-dependent signaling pathways. (unmc.edu)
Fiche J-B*, Smokvarska M , Mari S , Alcon C , Dumont X , Hematy K, Jaillais Y, Nollmann M, Maurel C (2019) Osmotic stress activates two reactive oxygen species pathways with distinct effects on protein nanodomains and diffusion . (inra.fr)
Chamberlain, L.H., D. Roth, A. Morgan, R.D. Burgoyne(1995) Distinct effect of α-SNAP, 14-3-3 proteins, and calmodulin on priming and targeting of regulated exocytosis. (concordia.ca)

The mutant protein 3 fails to assemble into pf-14 flagella and is maintained within a cytoplasmic pool of unassembled radial spoke polypeptides, as indicated by immunoblot analysis of proteins from whole cells and isolated axonemes using antisera to several radial spoke polypeptides. (rupress.org)
Thus, TPK1 seems to provide for a Ca(2+)- and 14-3-3-sensitive mechanism capable of controlling cytoplasmic potassium homeostasis in plants. (tu-darmstadt.de)

The tweezers inhibit binding between the 14-3-3 protein and two partner proteins--a phosphorylated (C-Raf) protein and an unphosphorylated one (ExoS)--in a concentration-dependent manner. (tue.nl)
Taken together, our findings suggest that AKT and 14-3-3σ cooperatively regulate TC45 nuclear translocation in a critical step of an early protective mechanism against UVB exposure that signals the deactivation of STAT3 in order to promote keratinocyte cell death and inhibit keratinocyte proliferation. (oncotarget.com)

In: The Plant journal : for cell and molecular biology, 52 (3), pp. 449-459. (tu-darmstadt.de)
Molecular dynamics simulations of three HRV14:WIN complexes suggest that portions of the WIN compounds and viral protein near the entrance of the binding pocket are more flexible than portions deeper within the beta-barrel. (rcsb.org)
The present study aims to connect Ephrin/14-3-3 to other molecular aspects already elucidated in schizophrenia. (fapesp.br)
Use of Predicted Amino Acid Sequence of Envelope-Nonstructural Protein 1 Region to Study Molecular Evolution of Epidemic-Causing Dengue-2 Strains. (who.int)

14-3-3ζ is one of 7 members of the 14-3-3 protein family, which is ubiquitously expressed and highly conserved among plants and mammals. (wikidoc.org)

Yields 2 servings at 7oz protein and 2 cups veggies each (plus req'd oil and salt). (3fatchicks.com)
Makes about 14 cups of soup or 14 servings. (yourlighterside.com)

Elevated amounts of 14-3-3 proteins in cerebrospinal fluid may be a sign of Creutzfeldt-Jakob disease. (wikipedia.org)
This test, the real-time quaking-induced conversion (RT-QuIC) assay, directly detects the disease associated form of the prion protein in cerebrospinal fluid. (canada.ca)
The appearance of surrogate biomarkers, typically a change in the amount of specific proteins in cerebrospinal fluid (CSF), provides additional supporting diagnostic data. (canada.ca)

14.3.3 proteins are ubiquitously expressed and self assemble into homo- and heterodimers, with the exception of 14.3.3σ, which exclusively forms homodimers and is found in cells of epithelial origin only. (tocris.com)
14-3-3 proteins generally form ~30 kDa-long homo- or heterodimers . (wikidoc.org)

KB228 administration increased oxygen consumption that was probably due to the overexpression of uncoupling protein-2 (UCP2) that was observed in animal and cellular models. (plos.org)

14.3.3 proteins are directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent growth and cell adhesion , and it is these pathways that often become dysregulated in disease states such as cancer . (tocris.com)

14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. (wikipedia.org)
Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. (genscript.com)

14.3.3 proteins represent an integration point for proliferative, survival, apoptotic and stress signaling pathways . (tocris.com)
[2] [3] 14-3-3ζ is a major regulator of apoptotic pathways critical to cell survival and plays a key role in a number of cancers and neurodegenerative diseases . (wikidoc.org)
This is important as 14-3-3 proteins regulate multiple cellular pathways, analysis of the phenotypes underlying loss of a specific 14-3-3 isoform must consider how different pathways contribute to the observed phenotype. (actrec.gov.in)
In this context, this project proposes to study the Ephrin/14-3-3 signaling pathways, which were found dysregulated during the master's project of the proponent, while studying the proteome of human brain tissue. (fapesp.br)

Protein X, as well as a peptide derived from it, bolstered mitochondrial function in the stressed cells. (alzforum.org)
As a control, they used a mutated version of the protein that lacked a mitochondrial localization sequence. (alzforum.org)
They found that the C-terminal third, with a mitochondrial localization tag added, provided as much protection as full protein X. This small peptide, which they called PX3, could be administered intranasally, achieving high levels in the striatum and distributing throughout the brain and spinal cord, as well as in some peripheral organs. (alzforum.org)
The longer protein of 23 kDa consists of 205 amino acids, and is located in the cytosol and mitochondrial intermembrane space. (dovepress.com)
Using an example of a mitochondrial protein degradation study with NaH 14 CO 3 as the precursor label, we explain the limitations of the method and our approaches to mathematical correction. (portlandpress.com)

14.3.3 proteins are phospho-serine/-threonine binding proteins that have a diverse array of partners including transcription factors, biosynthetic enzymes, cytoskeletal proteins , signaling molecules, apoptosis factors and tumor suppressors. (tocris.com)
In the cytoplasm, the encoded protein may function to regulate apoptosis. (wikipedia.org)
Here, we report that TC45 is translocated by an AKT/14-3-3σ-mediated mechanism in response to UVB exposure, resulting in increased apoptosis and decreased keratinocyte proliferation. (oncotarget.com)
Ras- and Rho-related proteins are small GTPases activated downstream of multiple receptors that control many cellular processes including cell cycle progression, apoptosis, cell motility, and cellular differentiation. (ucsd.edu)

The TPR snap helix: a novel protein repeat motif from mitosis to transcription. (embl.de)

A phylogenetic analysis of 27 plant species clustered the 14-3-3 proteins into four groups. (wikipedia.org)
The neuronal proteins are homologous to the embryonic lethal abnormal visual (ELAV) protein in Drosophila species. (medscape.com)

SAHG, a comprehensive database of predicted structures of all human proteins. (nih.gov)
DNA-protein crosslinking in human white blood cells is as high as 0.5-4.5 per 107 bases and is found to increase as a function of age. (rsc.org)
As I do not think chaperones and proteins are sufficiently analogous to human communication, I do not think that he actually says that. (lesswrong.com)
One important nutrient is protein, which is essential to the human body because it is part of every cell, issue, and organ, allowing them to grow and repair. (cdc.gov)
Architecture of the human interactome defines protein communities and disease networks. (genscript.com)
Therefore, two forms of human ALR protein are found in hepatocytes. (dovepress.com)
X-Ray diffraction data have been obtained for nine related antiviral agents ("WIN compounds") while bound to human rhinovirus 14 (HRV14). (rcsb.org)
Commercial standard enteral nutrition preparations, whose whole protein components are casein and soy protein, do not achieve optimal uptake and utilization compared to whey proteins, which are more readily absorbed and utilized by the human gut. (centerwatch.com)

Static and kinetic site-specific protein-DNA photocrosslinking has major implications for transcription in general, for the topology determinants specifically for RNA polymerase II transcription, and the mechanistic determinants of contacts involved in nucleoprotein complexes. (rsc.org)
3 According to the central dogma, genetic information is maintained through semi-conservative replication of DNA and is sequentially propagated by two templated processes, the transcription of DNA to RNA, followed by translation of RNA to produce proteins. (ukdiss.com)

Understanding protein subcellular localization is important to determining the functional role of specific proteins. (oncotarget.com)
Béguin P, Mahalakshmi RN, Nagashima K, Cher DH, Kuwamura N, Yamada Y, Seino Y, Hunziker W, Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2. (ithanet.eu)

14-3-3 proteins play an isoform-specific role in class switch recombination. (wikipedia.org)
We have identi¬fied isoform-specific PKG anchoring proteins and are determining how they restrict and define cGMP signaling within cells. (ucsd.edu)

In bovine brain samples, 14-3-3 proteins were located in the 14th fraction eluting from a DEAE-cellulose column and in position 3.3 on a starch electrophoresis gel. (wikipedia.org)

In sharp contrast, however, information on electronic processes in biomolecules such as isolated proteins and DNA (and their complexes) is still in its infancy. (rsc.org)
Contact Mark Bedford ( [email protected] ) for experiments involving the use of protein domain microarrays and surface plasmon resonance (SPR), and contact Shawn Bratton ( [email protected] ) for experiments involving the biophysical analysis of protein complexes. (mdanderson.org)

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An Arabidopsis 14-3-3 protein can act as a transcriptional activator in yeast. (1/1483)

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins. (2/1483)

Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. (3/1483)

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (4/1483)

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. (5/1483)

Fusicoccin, 14-3-3 proteins, and defense responses in tomato plants. (6/1483)

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. (7/1483)

The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. (8/1483)

Encyclopedias as Topic

Electrophoresis, Starch Gel

Creutzfeldt-Jakob Syndrome

Electrophoresis

Chromatography, DEAE-Cellulose

Molecular Sequence Data

Starch

An Arabidopsis 14-3-3 protein can act as a transcriptional activator in yeast. (1/1483)

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins. (2/1483)

Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins. (3/1483)

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (4/1483)

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. (5/1483)

Fusicoccin, 14-3-3 proteins, and defense responses in tomato plants. (6/1483)

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. (7/1483)

The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes. (8/1483)

Recombinant Human CD3 zeta protein (ab112263) References

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The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor...

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