17-Hydroxycorticosteroids: A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.Sodium Salicylate: A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)11-Hydroxycorticosteroids: A group of corticosteroids bearing a hydroxy group at the 11-position.Hydroxycorticosteroids: A group of corticosteroids carrying hydroxy groups, usually in the 11- or 17-positions. They comprise the bulk of the corticosteroids used systemically. As they are relatively insoluble in water, salts of various esterified forms are often used for injections or solutions.17-Ketosteroids: Steroids that contain a ketone group at position 17.Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.Blood Urea Nitrogen: The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Adrenal Cortex: The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Pharmacological Processes: The metabolism of drugs and their mechanisms of action.Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Aldosterone Synthase: A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Heparitin Sulfate: A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.Dermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)Sulfates: Inorganic salts of sulfuric acid.Heparan Sulfate Proteoglycans: Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)Keratan Sulfate: A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.Chondroitin Sulfate Proteoglycans: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.Interleukin-1beta: An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.Dextran Sulfate: Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.Portraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)History, 17th Century: Time period from 1601 through 1700 of the common era.Adrenal Cortex HormonesProtein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.History of DentistrySocieties, Scientific: Societies whose membership is limited to scientists.Magic: Beliefs and practices concerned with producing desired results through supernatural forces or agents as with the manipulation of fetishes or rituals.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Pregnanolone: A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.Steroidogenic Factor 1: A transcription factor and member of the nuclear receptor family NR5 that is expressed throughout the adrenal and reproductive axes during development. It plays an important role in sexual differentiation, formation of primary steroidogenic tissues, and their functions in post-natal and adult life. It regulates the expression of key steroidogenic enzymes.Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.Steroid 17-alpha-Hydroxylase: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.Aromatase: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.Animal Testing Alternatives: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)Heroin Dependence: Strong dependence, both physiological and emotional, upon heroin.Opioid-Related Disorders: Disorders related or resulting from abuse or mis-use of opioids.Liver Diseases: Pathological processes of the LIVER.Narcotics: Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Opiate Substitution Treatment: Medical treatment for opioid dependence using a substitute opiate such as METHADONE or BUPRENORPHINE.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Bacteriuria: The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.Urine: Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Menu PlanningQuality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Conductometry: Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.Dictionaries, Medical18-Hydroxydesoxycorticosterone: An analog of desoxycorticosterone which is substituted by a hydroxyl group at the C-18 position.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Mineralocorticoids: A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.18-Hydroxycorticosterone: 11 beta,18,21-Trihydroxypregn-4-ene-3,20-dione.Sodium Chloride: A ubiquitous sodium salt that is commonly used to season food.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Steroid 11-beta-Hydroxylase: A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).Dictionaries, ChemicalMetabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Alberta: A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)British Columbia: A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Health Records, Personal: Longitudinal patient-maintained records of individual health history and tools that allow individual control of access.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Metabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.IranIslam: A monotheistic religion promulgated by the Prophet Mohammed with Allah as the deity.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Intertrigo: A superficial dermatitis occurring on skin surfaces in contact with each other, such as the axillae, neck creases, intergluteal fold, between the toes, etc. Obesity is a predisposing factor. The condition is caused by moisture and friction and is characterized by erythema, maceration, burning, and exudation.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Slipped Capital Femoral Epiphyses: A developmental deformity in which the metaphysis of the FEMUR moves proximally and anteriorly away from FEMUR HEAD (epiphysis) at the upper GROWTH PLATE. It is most common in male adolescents and is associated with a greater risk of early OSTEOARTHRITIS of the hip.Software: Sequential operating programs and data which instruct the functioning of a digital computer.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Hip Joint: The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Life Cycle Stages: The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Computer Graphics: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Gonadal Steroid Hormones: Steroid hormones produced by the GONADS. They stimulate reproductive organs, germ cell maturation, and the secondary sex characteristics in the males and the females. The major sex steroid hormones include ESTRADIOL; PROGESTERONE; and TESTOSTERONE.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Receptors, Steroid: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.Subject Headings: Terms or expressions which provide the major means of access by subject to the bibliographic unit.Unified Medical Language System: A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.ACTH Syndrome, Ectopic: Symptom complex due to ACTH production by non-pituitary neoplasms.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Pituitary-Adrenal System: The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
(1/17) Adrenosympathetic overactivity under conditions of work stress.

Serial measurements of urinary adrenaline, noradrenaline, and 11-hydroxycorticosteroid excretion were performed on 32 healthy men under two conditions of work stress; piecework and work on assembly line. A statistically significant increase in adrenaline, noradrenaline, and 11-hydroxycorticosteroids was observed for piecework and assembly line workers compared with salaried and 'ordinary' workers. The results support the assumption that psychosocial factors of an everyday type have significant effects on the sympathoadrenomedullary and adrenocortical function.  (+info)

(2/17) The factors controlling stem cell recirculation. II. ACTH-induced inhibition of migration of hemopoietic stem cells.

Injections of ACTH of prolonged action (twice 1.5 units per mouse) given to lethally (800 R) irradiated mice with a hind limb shielded to the middle of the tibia brought about a twofold decrease in the number of spleen colonies. ACTH injections after sublethal whole-body irradiation (600 R) did not affect the number of endogenous spleen colonies. ACTH injection of normal mice brought about a substantial decrease in the CFU content in the circulating blood at the time of increased 11-hydroxycorticosteroid concentrations in the plasma. The results obtained are interpreted as inhibition of CFU migration from a shielded area of bone marrow induced by a high 11-hydroxycorticosteroid content in the plasma that followed ACTH injections which had no mitostatic effect on CFU proliferation.  (+info)

(3/17) Adrenal function in 23 children with paracoccidioidomycosis.

Adrenal involvement by Paracoccidioides brasiliensis was described at necropsies and in many clinical studies, but only in adults. Therefore, the aim of this study was to evaluate adrenal function in children with paracoccidioidomycosis. Twenty-three children with the systemic form of paracoccidioidomycosis were evaluated and divided in two Groups: Group A (n = 8) included children before treatment and Group B (n = 15) children after the end of treatment. Plasma cortisol (basal and after ACTH test), ACTH, renin activity, aldosterone, sodium and potassium were measured. They were within normal range in all cases, except for renin activity and aldosterone, which were elevated in some cases. Group A patients showed basal and post-ACTH cortisol levels significantly greater than Group B patients. The results showed that adrenal function was not compromised in these children with paracoccidioidomycosis.  (+info)

(4/17) Cushing's syndrome due to huge adrenocortical multinodular hyperplasia.

A case of Cushing's syndrome due to huge adrenocortial multinodular hyperplasia who was shown to be hyperresponsive to ACTH administration, unresponsive to metyrapone administration and resistant to dexamethasone high dose suppression was reported. After two years' duration of his symptoms, the multinodular adrenals weighing 161 g in total were removed by bilateral adrenalectomy which abolished his symptoms. Postoperatively, plasma ACTH rose gradually to above normal levels, suggesting the presence of primary disorder in the hypothalamus-pituitary axis.  (+info)

(5/17) Precocious development of UDP-glucuronyltransferase activity in chick-embryo liver after administration of adrenocorticotropic hormone and of certain 11beta-hydroxy corticosteroids.

1. Precocious development of UDP-glucuronyltransferase (EC 2.4.1.17) and of glucuronidation by endogenous compounds of known chemical composition is reported for the first time. 2. This development occurs precociously in chick-embryo liver after administration to the egg of mammalian adrenocorticotropic hormone, of Synacthen (a synthetic compound possessing adrenocorticotropic activity), or of certain corticosteroids possessing a hydroxy or an oxo group at C-11. 3. Corticosterone-dependent transferase development parallels the rise of infused corticosterone in plasma, but does not require the presence of embryo pituitary in ovo, and is demonstrable in embryo liver explants in vitro. 4. Competence of embryo liver transferase to respond to corticosterone (or dexamethasone) begins over days 13-14, the time of competence to respond to grafted pituitary gland. 5. The transferase appearing after treatment with corticosterone or adrenocorticotropic hormone, like that appearing after pituitary grafting or on natural development and unlike that from the untreated embryo, is markedly activated by membrane-perturbation procedures, suggesting it appears through induction, not activation. 6. Thyroxine and tri-iodothyronine accelerate transferase development after treatment with adrenocorticotropic hormone or corticosteroid to the rate seen after pituitary grafting. 7. A wide range of other hormones and steroids did not obviously influence transferase development in this system. 8. We suggest that grafted pituitary gland evokes precocious transferase development in embryo liver through production of adrenocorticotropic hormone and hence of the active corticosteroids; thyrotropin and thyroxine hasten the process. The role of this mechanism in the natural development of UDP-glucuronyltransferase is discussed.  (+info)

(6/17) Comparison of corticotrophin and corticosteroid response to lysine vasopressin, insulin, and pyrogen in man.

Plasma corticotrophin (ACTH) and corticosteroid levels in response to lysine vasopressin (LVP), insulin hypoglycaemia, and pyrogen have been compared in seven subjects with normal pituitary adrenal function. Intramuscular vasopressin was a weak stimulus to corticotrophin release, peak values lying within the range 49 to 141 pg/ml. Insulin hypoglycaemia consistently caused a more noticeable increase, with peak levels between 114 and 364 pg/ml, while pyrogen was the most powerful, corticotrophin levels rising to between 209 and 1,725 pg/ml. Peak plasma corticosteroid levels showed less pronounced differences between the three tests, and correlated poorly with peak ACTH levels. Thus, relatively small acute changes in corticotrophin levels produce near-maximal adrenal stimulation. Under these conditions, plasma corticosteroid measurements do not accurately reflect circulating corticotrophin levels. These findings help to explain the physiological basis of several observations on the corticosteroid responses to these clinical test procedures.  (+info)

(7/17) Effects of metoclopramide and bromocriptine on the renin-angiotensin-aldosterone system in man. Dopaminergic control of aldosterone.

This study was designed to investigate the possible role of dopaminergic mechanisms in the control of the renin-angiotensin-aldosterone system in normal man. Six normal male subjects in metabolic balance at 150 meq sodium, 60 meq potassium constant intake received the specific dopamine antagonist, metoclopramide, 10 mg i.v. or placebo followed by angiotensin II infusion 1 h later on 2 consecutive days. Metoclopramide increased plasma aldosterone concentration from 8.2+/-2.2 to 21.0+/-3.3 ng/100 ml (P < 0.005) and plasma prolactin concentration from 18.0+/-4.0 to 91.7+/-4.0 ng/ml (P < 0.001) within 15 min of its administration. At 1 h, plasma aldosterone and prolactin concentrations remained elevated at 16.8+/-2.1 ng/100 ml (P < 0.01) and 86.8+/-15.9 ng/ml (P < 0.005), respectively. Angiotensin II at 2, 4, and 6 pmol/kg per min further increased plasma aldosterone concentration to 27.2+/-3.4, 31.9+/-5.7, and 36.0+/-6.7 ng/100 ml (P < 0.02), respectively. Placebo did not alter plasma aldosterone or prolactin concentrations, but angiotensin II increased plasma aldosterone concentration to 13.7+/-2.4, 19.0+/-1.9, and 23.3+/-3.2 ng/100 ml (P < 0.005). The increment of plasma aldosterone concentration in response to angiotensin II was similar after metoclopramide or placebo. The six subjects also received the dopamine agonist, bromocriptine, 2.5 mg or placebo at 6 p.m., midnight, and 6 a.m. followed by angiotensin II infusion on 2 consecutive d. Bromocriptine suppressed prolactin to <3 ng/ml. After placebo, plasma aldosterone concentration increased from 5.2+/-1.4 to 12.3+/-1.7, 17.2+/-2.2, and 21.8+/-3.5 ng/100 ml (P < 0.01) and after bromocriptine from 7.2+/-1.0 to 14.7+/-3.0, 19.8+/-3.2, and 23.4+/-1.6 ng/100 ml (P < 0.001) with each respective angiotensin II dose. No difference in the response to angiotensin II after bromocriptine or placebo was observed. Plasma renin activity, free 11-hydroxycorticoid concentration, and serum potassium concentration were unchanged by metoclopramide or bromocriptine. The results suggest that aldosterone production is under maximum tonic dopaminergic inhibition which can be overridden with stimulation by angiotensin II in normal man.  (+info)

(8/17) The circadian rhythms of human subjects without timepieces or indication of the alternation of day and night.

1. Seven solitary subjects, and two groups of four, spent from 5 to 13 days in an isolation unit without knowledge of time. Three solitary subjects and one group of four adopted fairly regular activity habits with a period of 25-27 h; one subject adopted a period of 30 h, and one of 27 h initially, decreasing to 24-25 h after a few days. One group of four awoke roughly every 24 h, after a sleep which was alternately about 8 h, or about 4 h and believed by the subjects to be an afternoon siesta. Two solitary subjects alternated sleeps of about 8 or 16 h, separated by 24 h of activity.2. Deep temperature in all subjects oscillated with a period of 24-26 h, which was thus commonly distinct from their activity habits.3. Urinary potassium followed a rhythm whose period, though usually close to, was sometimes distinct from, that of temperature. A secondary period corresponding to that of activity was also sometimes present.4. Urinary sodium and chloride usually gave evidence of two periodic components, one corresponding to activity and the other to the rhythm of either temperature or of urinary potassium.5. Urinary creatinine and phosphate usually followed the subject's routine of activity.6. Plasma samples were collected on a few occasions and analysed for phosphate and 11-hydroxycorticosteroids. Changes in plasma phosphate were usually, but not always, associated with similar changes in urinary phosphate, and changes in plasma corticosteroids were often, but not always, associated with similar changes in urinary potassium shortly afterwards.7. Observations are recorded on a subject alone in a cave for 127 days. His activity habits, though wildly variable, gave evidence of a period of 25.1 h and his urinary electrolyte excretion indicated a shorter period, of 24.6 h. During the following 3 days, when he remained in the cave but was visited frequently, his plasma corticosteroids and urinary potassium oscillated with a period of 16 h.8. The possible mechanisms controlling these rhythms are discussed.  (+info)

*  Hydroxycorticosteroids
... (OHCSs) are corticosteroids that have an additional hydroxy (-OH) group. There are two main positions ... 11-hydroxycorticosteroids (11-OHCSs) include: aldosterone corticosterone hydrocortisone 17-hydroxycorticosteroids (17-OHCSs) ... where the hydroxy group may be added: at carbon atom 11, and at carbon atom 17. ...
*  List of MeSH codes (D06)
17-hydroxycorticosteroids MeSH D06.472.040.585.478.195 --- cortisone MeSH D06.472.040.585.478.225 --- cortodoxone MeSH D06.472. ... hydroxycorticosteroids MeSH D06.472.040.585.353 --- 11-hydroxycorticosteroids MeSH D06.472.040.585.353.118 --- aldosterone MeSH ...
Semantic Scholar extracted view of Chemical method for the determination of 17-hydroxycorticosteroids and 17-ketosteroids in urine following hydrolysis with beta-glucuronidase. by Elizabeth M. Glenn et al.
Antinuclear Antibody Screen (ANA); Anti Strptolysin-O (ASO); Calcium (Ca); Chem 6 [Blood Urea Nitrogen (BUN); Creatinine; Electrolytes [ Carbon Dioxide (CO2); Chloride (CL); Potassium (K); Sodium (Na) ]; Complete Blood Count [
The metyrapone test has been improved by specific measurement of plasma 11-deoxycortisol. This simplified method measures 11-deoxycortisol and cortisol in a sample of 0.1 ml of plasma after a standard dose of metyrapone. In normal patients, after metyrapone ingestion, plasma 11-deoxycortisol rises from a base line of 0.8 ± 0.8 µg/100 ml to 16.8 ± 4.4 µg/100 ml, and plasma cortisol falls from 13.5 ± 5.1 µg/100 ml to 3.3 ± 2.8 µg/100 ml. After metyrapone 11-deoxycortisol is reduced only in adrenocorticotrophin (ACTH) deficiency. Patients with hypopituitarism or chronic corticoid therapy and 9 of 12 acromegalics had subnormal levels. Patients with the "empty sella" syndrome or trophic hormone deficiency other than ACTH had normal levels. In primary hypothyroidism postmetyrapone 11-deoxycortisol is significantly greater than in normals. This difference is thought to be caused by delayed metabolic clearance of the steroid. Simultaneous measurement of serum cortisol affords an internal ...
Looking for online definition of 11-deoxycortisol in the Medical Dictionary? 11-deoxycortisol explanation free. What is 11-deoxycortisol? Meaning of 11-deoxycortisol medical term. What does 11-deoxycortisol mean?
Effect of altered acid-base balance, induced by the intravenous infusion of either hydrochloric acid or sodium bicarbonate, on adrenocortical function in anesthetized dogs was studied. The secretory activity of the adrenal cortex was determined by measuring 17-hydroxycorticosteroids in adrenal venous blood. Adrenocortical stimulation occurred in dogs with a profound decrease in arterial ph and bicarbonate concentration in the presence of a normal arterial CO2 tension (acid infusions) and in dogs with increased arterial CO2 tension and bicarbonate concentration in the presence of a normal arterial ph (bicarbonate infusions). It is concluded that concomitant alterations in both arterial ph and CO2 tension are not required to initiate an adrenocortical response, and it is suggested that a suitable change in either of these factors may act as a pituitary-adrenocortical stimulus.. ...
E. coli Source ß-Glucuronidases
ß-Glucuronidase is a ~290 kDa tetrameric protein with an isoelectric point of 4.8.1 Unlike the enzyme preparations from mollusks that naturally contain ß-glucuronidase and sulfatase activities in almost equal amounts, the preparation of ß-glucuronidase from E. coli is essentially free of sulfatase activity. The enzyme from E. coli has a high rate of hydrolytic activity and it retains this activity during hydrolysis better than similar enzymes that are more sensitive to changes in the concentration of ß-glucuronide conjugates. The enzyme preparation from E. coli has been shown to be useful for determining the presence of androsterone, 17-hydroxycorticosteroids, and estriol in urine.2 The E. coli enzyme has also been shown to be more active against estrogen conjugates than other sources of the enzyme.3
Optimal pH: 6-7

References
1. Kim, D-H, et al., Biol. Pharm.
Author: Kellner, M. et al.; Genre: Journal Article; Published in Print: 2004-08; Keywords: PTSD; metyrapone; dexamethasone; HPA axis; ACTH; cortisol; Title: Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings
The adrenal glands, ovaries, testes, and placenta produce steroid hormones, which can be subdivided into 3 major groups: mineral corticoids, glucocorticoids, and sex steroids. Synthesis proceeds from cholesterol along 3 parallel pathways, corresponding to these 3 major groups of steroids, through successive side-chain cleavage and hydroxylation reactions. At various levels of each pathway, intermediate products can move into the respective adjacent pathways via additional, enzymatically catalyzed reactions (see Steroid Pathways in Special Instructions).. 21-Deoxycortisol is an intermediate steroid in the glucocorticoid pathway. While the main substrate flow in glucocorticoid synthesis proceeds from 17-hydroxyprogesterone via 21-hydroxylation to 11-deoxycortisol and then, ultimately, to cortisol, a small proportion of 17-hydroxyprogesterone is also hydroxylated at carbon number 11 by 11-beta-hydroxylase 1 (CYP11B1), yielding 21-deoxycortisol. This in turn can also serve as a substrate for ...
Specifically, Barnaby has been studying the growth of kinetin-based nanostructures and the growth of selenium nanoparticles as biocompatible materials for drug delivery for prevention of oxidative cellular damage. She has been examining the potential of these materials as radical scavengers and investigating their efficiency as supports for enzymes such as glutathione peroxidase, which plays a vital role in prevention of oxidative damage. These materials have been found to survive in live cell cultures of normal rat kidney cells, which is promising and she hopes that she will be soon be moving on to conduct in vivo studies. She has already presented at conferences such as the New York American Chemical Society undergraduate research symposium, the Columbia University undergraduate research symposium, the Fordham undergraduate research symposium, and ECSC, which involved undergraduate participants from colleges and universities all over the East Coast ...
Looking for online definition of 17-ketosteroids or what 17-ketosteroids stands for? 17-ketosteroids is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
Measurement of the cortisol:creatinine ratio in the first urine specimen passed on waking obviates the need for a timed collection, and has been used by some as a sensitive screening test, particularly if cyclical Cushings syndrome is suspected. Urine aliquots are stable at room temperature for up to 7 days, and can then be sent by post to the local endocrine laboratory.. Late night plasma/salivary cortisol. In normal subjects, plasma cortisol concentrations are at their highest first thing in the morning and reach a nadir at around midnight (up to100 nmol/litre in the morning and ,50 nmol/litre at midnight effectively excluding Cushings syndrome). This circadian rhythm is lost in patients with Cushings syndrome, such that in most patients the 09.00 level of plasma cortisol is normal, but nocturnal levels are raised. Random morning levels of plasma cortisol are therefore of little value in making the diagnosis. In addition, various factors, such as the stress of venepuncture, intercurrent ...
CushingS Disease Caused By Prednisone. Cushings Syndrome - Adverse Effects of PrednisoneCushings syndrome is a condition that is caused by excessive cortisol, which can occur with the use of corticosteroid drugs such as prednisone.A+ cushing s disease caused by prednisone , OnlineDrug☀ , Best Cheap , ☀☀☀ cushing s disease caused by prednisone ☀☀☀. No side effects cushing s disease caused by prednisone,The offer is limited.. Get canine cushings disease caused by prednisone - macario.loan , Discount , ☀☀☀ canine cushings disease caused by prednisone ☀☀☀. We have special offers for you. canine cushings disease caused by prednisone,buy Cushings syndrome - WikipediaCushings syndrome is caused by either excessive cortisol-like medication such as prednisone is the most common form of Cushings syndrome. Cushings disease A+ cushing s disease caused by prednisone , OnlineDrug☀ , Best Price , ☀☀☀ cushing s disease caused by prednisone ☀☀☀. Are You Searching ...
A better testing choice is the Metyrapone test.. Unlike ACTH which requires an injection, the metyrapone drug can be given PO orally. The metyrapone test is superior to the ACTH stimulation test because evaluates both hypothalamic and adrenal function. HCG stimulates testicular production of testosterone without impairing fertility, and is therefore a preferred treatment in the er age group. He was also given a small dosage of natural thyroida half grain tablet daily.. Additional treatment protocols were also given as outlined by Dr. Jim had hypothalamic damage from MDMA drug use which caused his low hormone levels and chronic fatigue. LH and FSH then travel to the testicle to stimulate testosterone LH and sperm production FSH.. Chronic recreational drug use with Ecstasy. For Part Three, Click Here Low Testosterone From Pain Pills by Jeffrey Dach MD Dr John Crisler on HCG for Symptoms of Low Testosterone Low Testosterone Diagnosis and Treatment by Jeffrey Dach MD More articles on Low ...
This drug was approved for use in patients with endogenous Cushings syndrome who have type 2 diabetes or glucose intolerance and are not candidates for surgery or who have not responded to prior surgery. Korlym should never be used (contraindicated) by pregnant women.. Prior to FDAs approval of Korlym, there were no approved medical therapies for the treatment of endogenous Cushings syndrome.. Endogenous Cushings syndrome is a serious, debilitating and rare multisystem disorder. It is caused by the overproduction of cortisol (a steroid hormone that increases blood sugar levels) by the adrenal glands. This syndrome most commonly affects adults between the ages of 25 and 40. About 5,000 patients will be eligible for Korlym treatment, which received an orphan drug designation by the FDA in 2007.. Korlym blocks the binding of cortisol to its receptor. It does not decrease cortisol production but reduces the effects of excess cortisol, such as high blood sugar levels.. The safety and efficacy of ...
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We herein report two cases involving a mother and daughter who presented with clinical features of Cushings syndrome (CS) at 50 and 29 years of age, respectively, and were both found to have adrenocorticotropic hormone-independent adrenal adenoma. Furthermore, a new adenoma was detected in the contralateral adrenal gland in the mother 10 years after surgical treatment, when she presented with subclinical CS. The pathogenesis of this disorder, including the presence of unknown genetic abnormalities causing hereditary CS, is currently poorly understood. In this report, we describe our experience with and consider the pathophysiological implications of two rare and very interesting cases of familial CS ...
A sample of venous blood and a 24 hour urine collection may be collected for this test. Methods used collect a sample for this test vary. Depending on the method used, you may need a sample collected more than once, over multiple days, or at specific times. Ask the healthcare worker to explain the details of this test to you. Venous blood: When a blood sample from a vein is needed, a vein in your arm is usually selected. A tourniquet (large rubber strap) may be secured above the vein. The skin over the vein will be cleaned, and a needle will be inserted. You will be asked to hold very still while your blood is collected. Blood will be collected into one or more tubes, and the tourniquet will be removed. When enough blood has been collected, the healthcare worker will take the needle out. 24 hour urine collection: For a 24-hour urine collection, all of the urine that you pass over a 24-hour time period must be collected. If you are in the hospital, a healthcare worker will collect your urine. You ...
This video explains Cushings syndrome and how to differentiate between different types of Cushings syndrome and also how to treat Cushings syndrome ...
Anti-estrogen Steroids Powder Formestane Lentaron CAS 566-48-3 Quick Detail: Name: Formestane Other name: Lentaron; CAS: 566-48-3 MF: C19H26O3 MW: 302.41 Assay: 99% Appearance:White powder. Formestane Description: Formestane is currently one of the...
Diagnosis of Cushings Syndrome. William Harper, MD, FRCPC Endocrinology & Metabolism Assistant Professor of Medicine McMaster University. Nomenclature. Cushings Syndrome Hypercortisolism of any cause Cushings Disease Corticotropin (ACTH) secreting pituitary adenoma....
53-35-0 - GNFTWPCIRXSCQF-UJXAPRPESA-N - 6beta-Hydroxycortisol - Similar structures search, synonyms, formulas, resource links, and other chemical information.
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
English - Chinese Bio-chemistry Dictionary. By: Joe Hing Kwok Chu. Back to Biochemistry Dictionary Main page. Adrenocortical Hormone, Page 1 Page 1 (index 11-deoxycortisol~18-hydroxycorticosterone). page 2 (3b-hydroxydehydrogenase~cardiac inhibiting factor). page 3 (circadian rhythms ~ dexamethasone). page 4 (metyrapone test ~ stress reaction). page 5 (tetrahydrocortisol ~ water test). Go to Next page ...
Cushings syndrome was first discovered by Harvey Cushing. In this situation, your body is damaged by an overload of cortisol. This can cause diabetes, high blood pressure and slow metabolism. - Cushings syndrome - Slow Metabolism - Low Carb at BellaOnline
A simple test that measures free cortisol levels in saliva at midnight - called a midnight salivary cortisol test - showed good diagnostic performance for Cushings syndrome among a Chinese population, according to a recent study. The test was better than the standard urine free cortisol levels and may be an alternative for people with end-stage kidney disease, in whom measuring cortisol in urine is challenging. The study, "Midnight salivary cortisol for the diagnosis of Cushings syndrome in a Chinese population," was published in Singapore Medical Journal. Cushings syndrome, defined by excess cortisol levels, is normally diagnosed by measuring the amount of cortisol in bodily fluids. Traditionally, urine free cortisol has been the test of choice, but this method is subject to complications ranging from improper collection to metabolic differences, and its use is limited in people with poor kidney function. Midnight salivary cortisol is a test that takes into account the normal fluctuation of ...
Another name for Cushings Syndrome is Cushings Syndrome. Cortisol is a hormone that is produced by the adrenal gland. The important functions of cortisol ...
Cushings Syndrome Definition - Cushings syndrome is a disorder that occurs when the body is exposed to abnormally high levels of the hormone...
Cushings Syndrome also called hypercortisolism: symptoms, cause, treatment, long-term outlook, complications, prevention, risks
Information about this survey and your consent to participate Patients with Cushings syndrome report decreased quality of life before and after surgical treatment. We are investigators at the U.S. National Institutes of Health who care for patients with Cushings syndrome. We want to learn more about the patients experience during the post-surgical recovery phase with…
Helix pomatia, conhecido pelo nome comum de escargot, é uma espécie de caracol terrestre comestível de grandes dimensões, pertencente à família Helicidae. A espécie é nativa da Europa, sendo objecto de captura e de cultura em instalações de helicicultura,sendo comercializada para fins gastronómicos sob o nome francês de escargot. [IUCN Red List of Threatened Species http://www.iucnredlist.org/apps/redlist/details/156519/0] Linnaeus C. (1758). Systema naturae per regna tria naturae, secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis. Tomus I. Editio decima, reformata. pp. [1-4], 1-824. Holmiae. (Salvius). (em russo) Roumyantseva E. G. & Dedkov V. P. (2006). "Reproductive properties of the Roman snail Helix pomatia L. in the Kaliningrad Region, Russia". Ruthenica 15: 131-138. abstract O Commons possui imagens e outras mídias sobre Helix pomatia Helix pomatia no NCBI (em inglês) Animal Diversity Web ...
To our knowledge, this is the youngest patient reported with ICS due to intranasal use of a prescribed dose of an ophthalmic steroid. Our patient was diagnosed after only a 6-week course of dexamethasone ocular drops compared with a previously prescribed 3-month course.6 Given that intranasal steroids are commonly prescribed to infants and children for a variety of diagnoses, this case highlights the risks inherent in the use, even short-term, of intranasal steroid drops, particularly in young infants, for both adrenal suppression and linear growth deceleration. Because oral and topical glucocorticoids are a more common cause of ICS, there are limited reports of intranasal steroids as the etiology,5-9 with patients being diagnosed with ICS anywhere from 2 to 4 months to several years after steroid initiation.. Infants given intranasal dexamethasone drops may be at higher risk for systemic absorption through the gastrointestinal tract because they are often supine during administration and may ...
Cushings Syndrome Endrocrineinfo.com Cushing syndrome occurs when your body is exposed to elevated degrees of the hormone cortisol for quite a long time. The most usual cause of Cushing syndrome, occasionally called hypercortisolism, is the use of oral corticosteroid medication. The status may also happen when your body makes an excessive amount of cortisol. Too much cortisol can produce a […]. » Read more ...
Surgical stress is the systemic response to surgical injury and is characterized by activation of the sympathetic nervous system, endocrine responses as well as immunological and haematological changes. Measurement of surgical stress is used in anaesthesia, physiology and surgery. Analysis of the surgical stress response can be used for evaluation of surgical techniques and comparisons of different anaesthetic protocols. Moreover they can be performed both in the intraoperative or postoperative period. If there is a choice between different techniques for a surgical procedure, one method to evaluate and compare the surgical techniques is to subject one group of patients to one technique, and the other group of patients to another technique, after which the surgical stress responses triggered by the procedures are compared. The technique with the least surgical stress response is considered the best for the patient. Similarly, a group of patients can be subjected to a surgical procedure where one ...
sodium sulfate is a very cheap material. The largest use is as filler in powdered home laundry detergents, consuming approx. 50% of world production. This use is waning as domestic consumers are increasingly switching to compact or liquid detergents that do not include sodium sulfate. Another formerly major use for sodium sulfate, notably in the US and Canada, is in the Kraft process for the manufacture of wood pulp. Organics present in the black liquor from this process are burnt to produce heat, needed to drive the reduction of sodium sulfate to sodium sulfide.. The glass industry provides another significant application for sodium sulfate, as second largest application in Europe. Sodium sulfate is used as a fining agent, to help remove small air bubbles from molten glass. It fluxes the glass, and prevents scum formation of the glass melt during refining. The glass industry in Europe has been consuming from 1970 to 2006 a stable 110,000 tonnes annually.. Sodium sulfate is important in the ...
The reference range of urinary 17-ketosteroids is as follows: Males: 10-20 mg (34-69 µmol)/24 h Females: 5-15 mg (17-52 µmol)/24 h
Thirty-four patients with Cushings Syndrome: our clinical experience in the past 20 years/ Otuz dort Cushings Sendromu olgusu: 20 yillik klinik deneyimlerimiz.
Make an appointment with your physician immediately. Tell them about all of your symptoms. Take pictures that show what you looked like prior to having symptoms of Cushings. Diagnosis is not as easy as one would expect.. The diagnosis of Cushings is based on a review of the patients medical history, a physical exam, and laboratory tests. This will help to determine if excess levels of cortisol (a steroid hormone) are present in the body.. Once Cushings syndrome has been diagnosed, it is important to find the cause of the cortisol overproduction. There are many tests used to diagnose Cushings.. There is a lot of research being done today on treatments. If left untreated, Cushings syndrome can be fatal.. ...
This article is a comprehensive overview of Cushings syndrome, which is caused by excess production of the hormone cortisol by the adrenal cortex. Learn about the history of this disease, along with the symptoms, diagnosis, and treatments for Cushings s
Cushings syndrome (hyperadrenocorticism) is a condition in which there is an excess of cortisol. It may be caused by drugs, such as prednisone, or by an excess of the bodys own cortisol, caused by a pituitary or adrenal tumor.
INCLUSION CRITERIA:. Patients with Cushing syndrome documented at the NIH will be recruited into this protocol prior to surgery intended to cure Cushing syndrome selectively. Thus, patients undergoing transsphenoidal exploration for resection of an adenoma, or unilateral adrenalectomy for an adenoma, or resection of a tumor producing ACTH ectopically will be candidates for this study. We will also recruit as many of the 500 patients treated since 1983 as possible, so as to have a group of late follow-up patients. These individuals will participate primarily by questionnaire.. Hematocrit about 30%. A CBC will be obtained prior to entering the study. Patients with hematocrit above 30% will be accepted into the study; iron replacement will be given to those patients with low TIBC.. Ages 18 - 85. Children less than 18 are being studied under other protocols and the questionnaire has not been validated for younger individuals.. For the questionnaire portion of the protocol there is an additional ...
DefinitionExogenous Cushing syndrome is a form of Cushing syndrome that occurs in people taking glucocorticoid (also called corticosteroid) hormones.
Too much cortisol in the body isnt just a sign of stress; it can also lead to Cushings syndrome (hypercortisolism). Learn about causes, symptoms and prevention.
Learn about Cushings syndrome, a hormonal disorder caused by high levels of cortisol. Symptoms include obesity, a rounded face, increased fat around the face, and a thinning of the arms and legs. Treatment and diagnosis are also described.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests, such as the metyrapone test and the phentolamine test, may be affected by this medicine.. If you plan to have surgery, including dental surgery, do not take aspirin (contained in this combination medicine) for 5 days before the surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.. If you think you or someone else may have taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine or taking alcohol or other CNS depressants with it may lead to unconsciousness and possibly death. Some signs of an overdose are continuing ringing or buzzing in ears; any hearing loss; severe confusion, drowsiness, or weakness; shortness of breath or slow or troubled breathing; staggering; and slow heartbeat.. This medicine may cause some people to become dizzy, ...
The possible presence of Cushings syndrome (CS) is suggested by certain symptoms and signs. Unfortunately, none of these are pathognomonic, and many are nonspecific (eg, obesity, hypertension, menstrual irregularity, and glucose intolerance). As a r
Symptoms of Cushings Syndrome in horses include weight loss, ulceration in the mouth, and excessive thirst and urination. Changes in body shape occur in horses with the disease, and they tend to be...
Learn more about Cushings Syndrome at Reston Hospital Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
The response, however, to Metopirone is subnormal; that is, no significant increase in 17-OHCS or 17-KGS excretion occurs.. This failure to respond to metyrapone may be interpreted as evidence of impaired pituitary-adrenal reserve. In view of the normal response to exogenous ACTH, the failure to respond to metyrapone is inferred to be related to a defect in the CNS-pituitary mechanisms which normally regulate ACTH secretions. Presumably the ACTH secreting mechanisms of these individuals are already working at their maximal rates to meet everyday conditions and possess limited "reserve" capacities to secrete additional ACTH either in response to stress or to decreased cortisol levels occurring as a result of metyrapone administration.. Subnormal response in patients with Cushings syndrome is suggestive of either autonomous adrenal tumors that suppress the ACTH-releasing capacity of the pituitary or nonendocrine ACTH-secreting tumors.. Excessive response: An excessive excretion of 17-OHCS or ...
Cortisol is the primary hormone of the adrenal cortex. Cortisol secretion is increased and the normal circadian rhythm is absent in Cushing Syndrome
Innovate Insights unravels its new study titled "Sodium Sulfate Market - Growth, Trends, and Forecast (2017-2023)". Effective exploratory techniques such as qualitative and quantitative analysis have been used to discover accurate data.. The Sodium Sulfate Market was estimated to be worth USD XXX billion in 2017 and is projected to reach USD XXX billion by the end of 2023, growing at a CAGR of XX% over the forecast period of 2018-2023. The Sodium Sulfate industry is highly competitive, due to a large degree of fragmentation in the market. Despite the fragmentation, the market is largely tied by the regulatory requirements for establishment and operation.. The scope of the report is limited to the application of the type, and distribution channel. The regions considered in the scope of the report include - North America, Europe, Asia-Pacific, and Rest of the World. This report presents the worldwide Sodium Sulfate market size (value, production and consumption), splits the breakdown (data status ...
I have had and still suffer from Cushings Syndrome symptoms. I have had a surgery to correct the problem (which involved getting a tumor and an adrenal gland removed), yet I still produce high levels of cortisol which is still being investigated. Some info on the condition from WebMD. What is Cushings syndrome? Cushings syndrome…
I have 5g of Formestane in NP Penetrate from about 1 1/2 years ago. I shake the bottle every week or two. The bottle has been kept in a cool dark
Cushings is a b**ch. Ive always thought that the mental part was at least as bad if not worse than the physical. Of course Im looking at it from a different perspective than the patient. I just (?) have to live with someone who has Cushings.. This is a quote from a "cured" Cushie. "My relationship with my hubby is way better. This disease does a good one on marriage - for anyone who thinks their spouse is the worst person ever, Im sorry but you need to take a few deep breaths, grit your teeth and wait for cure before deciding on a break-up...it may turn out that a lot of the blame is at your feet - not your partners. It really distorts your view of other people so try not to jump to conclusions about someone with this cloud over your head.". I really, really like that. With Bill I never know, is it him, is it the Cushings? Who is he? Do I know him? Did I ever know him? Which one of these "Bills" that talks to me is the real one? Does he know, does anyone know? Will the real Bill please ...
Are you sure that you are not eating a lot more when you exercise? You may want to read this latest report: For Weight Loss, Less Exercise May Be More High cortisol can be diagnosed by a blood,...
Free cortisol is useful in the detection of patients with Cushings syndrome for whom free cortisol concentrations are elevated.. ...
If you dont have a WellSpan primary care provider and would like to schedule a new patient appointment with a provider who is accepting patients, just log into your MyWellSpan account, and go to the Appointment Center section. As you progress through the scheduling process, you will be able to see the offices that are accepting new patients in relation to your zip code. If you are not enrolled in MyWellSpan, go to https://my.wellspan.org, call 1-866-638-1842 or speak with a member of the staff at a participating facility to sign up. New patient scheduling not available at all practices/programs. ...
Order NR5A2 + LRH1 ELISA Kits for many Reactivities. Chicken, Human, Mouse and more. Compare NR5A2 + LRH1 ELISA Kits and find the right product on antibodies-online.com.
Hey guys hope we all had a good Easter just after some advice, i have run h-drol and gained weight but had glandular fever so i have lost over 14
Hello! My 8yo son is home at least once/month for stomachaches. Most recently, it was about 2.5 weeks ago (he is home again today). The last time, he may ...
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Several embryotoxic agents, which includes sodium salicylate, were reported to induce vertebral variations in the form of supernumerary ribs (SNR) when administered to pregnant rodents. Because the biological significance of SNR in toxicological studies is still a matter of debate, we investigated the molecular basis of this defect by analyzing the possible involvement of Hox genes, known to specify vertebrae identity. Sodium salicylate (300mg/kg) was administered to pregnant rats on gestational day 9 (GD 9). On GD 13, the expression of several Hox genes, selected according to the position of their anterior limit of expression, namely upstream (Hoxa9), at the level (Hoxa10) and downstream (Hoxd9) to the morphological alteration, were analyzed. Posterior shifts in the anterior limit of expression of Hoxa10 and Hoxd9 were observed following exposure to salicylate, which could explain an effect at the level of the axial skeleton. This finding suggests that the appearance of ectopic ribs can be ...
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... Published by QYResearch at researchbeam.com . Global Sodium Salicylate Industry 2015 Deep Market Research Report is a research report by Key Manufacturers, Applications, Developments and Trends with covering regions China, US, Europe & Japan
1221 medications are known to interact with caffeine/pheniramine/phenylephrine/sodium citrate/sodium salicylate. Includes Adderall (amphetamine/dextroamphetamine), Fentora (fentanyl), Hydergine (ergoloid mesylates).
Sodium salicylate is used as an NSAID, to fever reducer, and an anti-fungal medication. Its also often used to treat conditions...
High dose sodium salicylate causes moderate, reversible hearing loss and tinnitus. Salicylate-induced hearing loss is believed to arise from a reduction in the electromotile response of outer hair cells (OHCs) and/or reduction of KCNQ4 potassium currents in OHCs which decreases the driving force for the transduction current. Therefore, enhancing OHC potassium currents could potentially prevent salicylate-induced temporary hearing loss. In this study, we tested whether opening voltage-gated potassium channels using ICA-105665, a novel small molecule that opens KCNQ2/3 and KCNQ3/5 channels, can reduce salicylate-induced hearing loss. We found that systemic application of ICA-105665 at 10 mg/kg prevented the salicylate-induced amplitude reduction and threshold shift in the compound action potentials recorded at the round window of the cochlea. ICA-105665 also prevented the salicylate-induced reduction of distortion products of otoacoustic emission (DPOAE). These results suggest that ICA-105665
This study was designed to determine the dose of salicylate necessary to produce substantial antipyresis, and to determine the relationship between the response to salicylate and prostaglandin infused into the same region of the preoptic area of the rabbit. The effect of preoptic infusions of three doses of sodium salicylate, or a control solution, on the fever produced by an intravenous injection of endogenous pyrogen was measured. The pyrogenic response to prostaglandin E1 injected into the same preoptic sites in the same rabbits was also monitored. The results showed that the 50 μg/μL per hour dose of salicylate did not produce significant antipyresis but that the 100 and 200 μg/μL per hour doses did. The results also showed a significant correlation between the magnitude of fever produced by prostaglandin E1 and the magnitude of antipyresis produced by sodium salicylate at a particular site. Those sites at which infusion of salicylate produced the most effective antipyresis were also the ones at
Everybody who reacted to tartrazine, sodium salicylate, or acetaminophen had also reacted to aspirin. 96% of them had sinusitis and 71% had nasal polyps.. The researchers used up to 650 mg aspirin (beginning with a lower dose if sensitivity was suspected), 600 mg sodium salicylate, and 650 mg Tylenol. For the dye, patients were given only 1, 5, 15, 25, and 50 mg of Yellow 5, in incremental doses.. NOTE: At least some of the patients were not on medications at the time of the study. It is not actually clear, but mention was made of "those patients whose medications could not be withheld and those receiving troleandomycin.". MedLine ,, Full Text ,, Get Password. ...
Gehor-Bosan B8 information about active ingredients, pharmaceutical forms and doses by Professional Health Products, Gehor-Bosan B8 indications, usages and related health products lists
An original, highly sensitive and specific high performance liquid chromatographic method has been developed for the measurement of aspirin and salicylate in plasma. Minimum concentrations of 10 xg/L (aspirin) and 0.5 mg/L (salicylate) can be measured using 1 ml of plasma. After collection, plasma is first treated with physostigmine sulfate to inhibit enzymatic hydrolysis of aspirin to salicylate. Maximal recovery is achieved using an acid extraction into anhydrous diethyl ether with a subsequent drying-down step in an iced water bath. Aspirin and salicylate are separated by elution with a mixture of methanol, 1-butanol, orthophosphoric acid, and water on a reversed-phase octadecyl silane column at 47°C and detected at 234 nm by ultraviolet absorption. Quantitation is achieved using the peak height ratio of aspirin and salicylate to internal standard (m-anisic acid). The assay has been used for the study of simultaneous aspirin and salicylate pharmacokinetics after a single oral dose of 100 mg ...
Anyone can be, or become, sensitive to anything, including salicylates. It happens when people or over exposed or continually exposed; however, in the case of salicylates, it usually happens to people with moderate to severe asthma, and then those sufferers develop chronic rhinosinusitis. It also tends to affect older adults or people who have worsening asthma problems, and, yet, the worsening asthma problems may be related to continual exposure to salicylates. So, its a vicious cycle as your health continues to deteriorate, and you experience more and more health problems.. If you have any of the above symptoms, the best way to determine if salicylates is your problem is to begin by eating a diet low in salicylates, and then slowsly add higher salicylate foods back into your diet. For more information on salicylates in food or how to conduct a test see the How Do I Get More Information?section at the bottom of this article. If you have salicylate problems and remove them from your life, your ...
The effects of salicylic acid on the pharmacokinetics of valproic acid were investigated in bile-exteriorized rats. A 50 mg/kg bolus dose of sodium valproate was injected iv to Long Evans rats with and without (control) prior treatment by constant infusion of salicylate to keep it at steady state plasma level (about 250 micrograms/ml). The plasma elimination of valproic acid followed a monoexponential decline in both salicylate-treated and control rats. A significant increase (p less than 0.01) in the disposition rate constant (kel), the volume of distribution (Vd), and the total clearance (Cltot) as well as a significant decrease (p less than 0.01) in the AUC and the elimination half-life (t1/2) were observed in the salicylate-treated rats. In spite of the significantly lowered total plasma level and increased unbound fraction of valproic acid in the salicylate-treated rats, there were no significant differences in unbound valproic plasma levels and unbound valproate pharmacokinetic parameters. ...
russell at DOGWOOD.BOTANY.UGA.EDU (Russell Malmberg) writes: ,Im looking for both a protocol and a reference for ,the use of sodium salicylate as a fluor for H3, S35, ,and C14 labelled protein acrylamide gels. Ive used 0.5 M salicylate-1.5% glycerol after the water wash for H3-fluorography with good success. The gels dont crack as readily during drying and the signal obtained was strong. (ref. Sambrook, et al. 1989. Molecular Cloning: a laboratory manual). -- Mark S. Strom, Ph.D. office: (206) 553-4182 UR Division, NW Fisheries Sci. Ctr. lab: (206) 553-7707 Natl. Marine Fisheries Ser., NOAA fax: (206) 553-4304 2725 Montlake Blvd. E., Seattle, WA 98112 email: strom at u.washington.edu ...
The salicylate assay aids in the diagnosis and treatment of salicylate overdose and in monitoring salicylate levels to insure appropriate therapy. Salicylates are a group of compounds used as analgesics, antipyretics and anti-inflammatory agents. Acetylsalicylic acid (aspirin) is the most commonly used salicylate. Salicylates are readily available over-the-counter and most salicylate therapy is the result of patient self-medication. For this reason, salicylates are often seen in overdose cases. Salicylate poisoning is seldom fatal, but causes side effects ranging from nausea, vomiting and tinnitus to fever, lethargy and coma. Prompt recognition and management are necessary to avoid serious consequences. ...
Derivative: Glycyrrhizinum Ammoniatum, Ammoniated Glycyrrhizin. Very sweet, odorless, dark-brown or red-brown scales; soluble in alcohol or water. It is derived from glycyrrhiza and combined with ammonia. Dose, 1 to 8 grains.. Action and Therapy.-Glycyrrhiza root is demulcent, laxative, and expectorant. It acts upon mucous surfaces, lessening irritation and relieving coughs, catarrhs, and irritation of the urinary tract. The powdered extract is sometimes used to give solidity to pills, and the powdered root as a dusting powder for the same. The fluidextract is an agreeable flavoring agent for other medicines and soothing to irritated bronchial surfaces. The bitterness of cascara, quinine, aloes, quassia, the acridity of senega, guaiac, and the taste of ammonium chloride and sodium salicylate are more or less masked by the fluidextract. Licorice root is an ingredient of Compound Licorice Powder. (See Senna).. ...
Benzyl Salicylate (benzyl ortho hydroxy benzoate) is an almost colourless liquid that has a mild balsamic, sweetly floral note possessing excellent blending capabilities. Often used ~like foundation is for make-up~ as a base for heavy florals such as ylang, gardenia, jasmine, lily etc. It is also used in functional products such as soap, shampoo and fabric softener. Along with Methyl Salicylate, salicylates "turn the most banal floral composition into a real perfume, with majestic weight and sweep" divulges Luca Turin. However some people are anosmic to it, including some perfumers. Guy Robert could not smell benzyl salicylate at all, but could instantly recognize its presence in perfume: "I recognize it as if it were a friend seen from behind in a crowd, by the cut of his shoulders". Indeed in the words of nose Bernand Chant "it produces a diffusing, blooming effect very pleasing to the public". Many orchid fragrances are built on salicylates, while the mysterious emerald glow of the vintage Je ...
If youre interested in forensic toxicology and are trying to determine the presence of salicylate by using a visual colorimetry, then look no further. This indepth and compelling video takes you into world of salicylate determination. Salicylate determination with visual colorimetry, Part I Using iron(III) nitrate to determine salicylate concentration in standardized salicylate solutions and urine. You can actually use any iron(III) salt, such as ferric chloride, ferric ammonium sulfate, and so on. Concentration is not critical
Instructions for use: Apply Facial Treatment Essence with cotton ball to face and neck, followed by Facial Treatment Clear Lotion For an extra boost use the Facial Treatment Mask Facial Treatment Essence: 75ml/2.5 fl.oz; Facial Treatment Clear Lotion: 30ml/ 1 fl.oz Facial Treatment Clear Lotion Ingredients: Water, Saccharomycopsis Ferment Filtrate*, Butylene Glycol, Polysorbate 20, Glycerin, Sodium Hyaluronate, PEG-150, Cellulose Gum, Disodium EDTA, Citric Acid, Salicylic Acid, Lactic Acid, Malic Acid, Sodium Citrate, Sodium Benzoate, Methylparaben Facial treatment Essence Ingredients: Galactomyces Ferment Filtrate, Butylene Glycol, Pentylene Glycol, Water, Sodium Benzoate, Methylparaben, Sorbic Acid Facial Treatment Mask Ingredients: Water, Saccharomycopsis Ferment Filtrate*, Butylene Glycol, Xanthan Gum, Sodium Salicylate, Methylparaben, Disodium EDTA
Benzalkonium chloride + choline salicylate is used in the treatment of .get complete information about benzalkonium chloride + choline salicylate including usage, side effects, drug interaction, expert advice along with medicines associated with benzalkonium chloride + choline salicylate at 1mg.com
Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children- Do not give aspirin or other salicylates to a child or a teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your childs doctor. This is very important because salicylates may cause a serious illness called Reyes syndrome in children and teenagers with fever caused by a virus infection, especially flu or chickenpox. Some children may need to take aspirin or another salicylate regularly (as for arthritis). However, your childs doctor may want to stop the medicine for a while if a fever or other symptoms of a virus infection occur. Discuss this with your childs doctor, ...
The use of an amperometric biosensor for rapid salicylate determination in blood is described. Photolitography was used to make gold electrodes on a polyester film. The plastic microcell was characterized using cyclic voltammetry to demonstrate the electrochemical performance of the system. The biosensor was constructed by immobilizing salicylate hydroxylase onto the working electrode of the plastic electrochemical microcell. The optimized working conditions were 0.1 mol L(-1) phosphate buffer at pH 7.6 with 0.5 mmol L(-1) of NADH and 300 mV vs. Au as the applied potential. The resulting biosensor exhibited a high sensitivity (97.4 nA/mmol L(-1) salicylate) and an adequate linear response range (1.2x10(-4) to 1.0x10(-3)mol(-1)). The biosensor performance was verified by determining salicylate in spiked blood samples and the results were statistically equivalent to the values obtained from the standard Trinder spectrophotometric method, with a 95% confidence level. This study shows the potential ...
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  FOOD INTOLERANCE NETWORK FACTSHEET Salicylates What are salicylates?How do you pronounce salicylates?What kinds of foods/products are they found in?What are some of the symptoms of salicylate sensitivity?How many people are
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The effects of salicylates on insulin resistance. There is significant overlap between the intracellular events induced by TGs (or FFAs) and TNF regarding the mechanisms of insulin resistance. Both stimuli activate IKK-β and decrease insulin-induced tyrosine phosphorylation of IRS-1; both increase intracellular ceramide concentrations, which leads to inhibition of Akt/protein kinase B activation and inhibition of GLUT-4 translocation. These effects induce a state of insulin resistance. The effects of salicylate compounds on these pathways may be divergent. That is, they may improve insulin resistance by blocking the activation of IKK-β (top), or they may worsen insulin resistance by inhibiting PG synthesis and thus potentiating TNF release (bottom). In addition, inhibition of PG will decrease synthesis of leptin, which is known to improve insulin sensitivity by stimulating IRS-1-associated PI 3-kinase activity. The beneficial effect of leptin on insulin action is thus decreased (bottom ...
The Texas Attorney General has ordered Texas prison authorities to release information on the amount of drugs on hand to carry out executions. We now know that Texas total supply of one of the three drugs used to perform executions is set to expire in March 2011, so Texas will have to try to obtain more of that drug, unless it decides to use the expired batch, which would probably be challenged in court ...
This drug is given in a hospital or clinic and will not be stored at home.. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.. ...
Salicylate (aspirin) is a widely used drug in clinics. Acute application of salicylate may cause reversible hearing loss, reduction of distortion product otoacoustic emission (DPOAE), and loss of outer hair cell (OHC) electromotility. A long-term application may cause tinnitus. Interestingly, it has been reported that a long-term salicylate application up-regulated expression of prestin, the OHC m
EFFECT OF PREDNISOLONE AND SALICYLATE ON SERUM THYROGLOBULIN LEVEL IN PATIENTS WITH SUBACUTE THYROIDITIS (pages 339-344). M. YAMAMOTO, S. SAITO, T. SAKURADA, H. FUKAZAWA, K. YOSHIDA, K. KAISE, N. KAISE, T. NOMURA, Y. ITAGAKI, K. YONEMITSU and K. YOSHINAGA. Version of Record online: 17 MAR 2008 , DOI: 10.1111/j.1365-2265.1987.tb01160.x. ...
Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces non-alcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism mediating these effects is unclear. Salicylate directly activates AMP-activated protein kinase (AMPK) via the β1 subunit but whether salsalate requires AMPK β1 to improve T2D and NAFLD has not been examined. Therefore, wild-type (WT) and AMPK β1 knockout mice (AMPK β1KO) were treated with a salsalate dose resulting in clinically relevant serum salicylate concentrations (∼1 mM). Salsalate treatment increased oxygen consumption, lowered fasting glucose, improved glucose tolerance and led to an ∼55% reduction in liver lipid content; effects observed in both WT and AMPK β1KO mice. To explain these AMPK-independent effects, it was found that salicylate increases oligomycin-insensitive respiration (state 4o) and directly increases mitochondrial proton conductance at clinical concentrations. This ...
Hyoscyamine produces many effects in the body, including relief from muscle spasms. Methenamine and methylene blue work as mild antiseptics that fight bacteria in the urine and bladder. Phenyl salicylate is a mild pain reliever. Hyoscyamine, methenamine, methylene blue, and phenyl salicylate is a combination medicine...
A key aspect of treatment is that salicylates, contained in aspirin and other compounds, completely block the effects of guaifenesin. Moreover, skin readily absorbs salicylates into the body. Salicylates are manufactured by all plants, the choicest parts of which are concentrated to make herbal medications, many cosmetics, and deodorants. Thus, patients being treated with guaifenesin cannot take aspirin or herbal medications, or use any skin creams or topical products which contain herbs, including aloe. Castor oil, Listerine, Ben Gay, and razors with aloe strips are among the many culprits that block the action of guaifenesin. Which products contain salicylates?. Another complicating factor in guaifenesin treatment is hypoglycemia, or "low blood sugar," better defined as carbohydrate intolerance. Some of the many symptoms of hypoglycemia are tiredness, panic, palpitations, and lightheadedness after eating sugar or starch. Hypoglycemia can be controlled by a strict diet that eliminates sugar, ...
SALICYLIC ACID 477 Methyl Salicylate. This is also known as artificial oil of wintergreen, and is obtained by the interaction of methyl alcohol and salicylic acid. It is a colourless liquid, having a characteristic, aromatic odour and a sweetish, warm, aromatic taste. It is slightly soluble in water, and freely soluble in alcohol, ether, chloroform, glacial acetic acid or carbon bisulphide. Methyl salicylate is taken accidentally, suicidally or to procure abortion, and causes symptoms of acute gastro-intestinal irritation resembling those of poisoning by salicylic acid, followed occasionally by death. About an ounce of methyl salicylate proved fatal to an adult woman in 15 hours42 and a dose of 50 ml. of methyl salicylate caused the death of a middle aged woman hi about 11 hours.43 Doses of 10 cc. to 12 cc. of methyl salicylate have killed children.44 On the other hand, a child, aged 2 years, recovered after swallowing an ounce.45 The treatment consists in the washing out of the stomach and ...
OBJECTIVE Salsalate is a nonacetylated salicylate that lowers glucose levels in people with type 2 diabetes (T2D). Here we examined whether salsalate also lowered serum-protein-bound levels of early and advanced glycation end products (AGEs) that have been implicated in diabetic vascular complications. RESEARCH DESIGN AND METHODS Participants were from the Targeting Inflammation Using Salsalate for Type 2 Diabetes (TINSAL-T2D) study, which examined the impact of salsalate treatment on hemoglobin A1c (HbA1c) and a wide variety of other parameters. One hundred eighteen participants received salsalate, 3.5 g/day for 48 weeks, and 109 received placebo. Early glycation product levels (HbA1c and fructoselysine [measured as furosine]) and AGE levels (glyoxal and methylglyoxal hydroimidazolones [G-(1)H, MG-(1)H], carboxymethyllysine [CML], carboxyethyllysine [CEL], pentosidine) were measured in patient serum samples. RESULTS Forty-eight weeks of salsalate treatment lowered levels of HbA1c and serum furosine (P
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The appearance of a severely tachypneic patient can prompt the urge to intubate. However, one must keep in mind that the organ of toxicity for aspirin is the brain. Aspirin has a pKa of 3.5 which means in acidic environments it is more likely to be non-ionized. This allows movement across membranes, including the blood-brain barrier. Aspirin causes a direct stimulation of the respiratory center inducing tachypnea. Frequently, salicylate-toxic patients will have a mixed metabolic acidosis with respiratory alkalosis. Intubation of these patients can remove the respiratory alkalosis component which causes blood pH to drop and allows more non-ionized aspirin to enter the brain [4]. Patients with salicylate toxicity may rapidly deteriorate or die if intubated because their minute ventilation on the ventilator often do not match their pre-intubation minute ventilation. ...
URIBEL (Methenamine,Phenyl salicylate,Methylene blue,Sodium phosphate monobasic,Hyoscyamine sulfate) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Salicylates were the first nonsteroid anti-inflammatory medicines (NSAIDs) to be utilized in any varieties and so are still trusted in human beings and livestock. plasma and eggs had been determined using high-performance liquid chromatography with ultraviolet detection and pharmacokinetic variables were calculated using a non-compartmental model. Mean residence time (MRT), minimal plasma concentration (Cmin, C16h) and elimination half-life (T1/2el) of SA showed gradual decrease in layers administered with a lower dose. Total body clearance (ClB) increased. Layers administered with the higher dose ML 161 showed a decrease only in the T1/2el. In the low dose group, SA was found only in the egg white and was low throughout the experiment. Egg whites from the higher dose group showed initially high SA levels which significantly decreased during the experiment. Yolk SA levels were lower and showed longer intervals of eradication and build up. Repeated administration of SS induces SA eradication, ...
Here is a short list of high phenol foods, which you would want to eliminate or at least reduce to prevent overload, is food dyes, tomatoes, apples, peanuts, bananas, oranges, cocoa, red grapes, colored fruits, and milk.. Here is the Feingold list of highly phenolic/high salicylate foods: Avoid anything - food, toiletries, cleaning supplies, art supplies - that has any of the following ingredients: Synthetic/artificial colors and flavors [for example, FD&C colors, vanillin], BHA, BHT, TBHQ, [all the preceding are made from or related to petroleum], Natural Flavoring (may contain salicylate), Natural Coloring (may contain salicylate), Aspirin and products containing aspirin or salicylic acid, Salicylates, Almonds, Apples, Apricots, Berries (all), Cherries, Chili powder, Cider & cider vinegar (apples), Cloves, Coffee, Cucumbers & pickles, Currants, Grapes & raisins, Nectarines, Oranges, Paprika, Peaches, Peppers (bell & chili), Plums, Prunes, Tangerines, Tea, Tomatoes, Wine & wine vinegar ...
Phenyl salicylate is used in the production of polymers, lacquers, adhesives, waxes and polishes. It acts as an antiseptic and mild analgesic. It is also used in the prevention of sunburn. It reacts with o-toluidine in 1,2,4-trichlorobenzene to give the corresponding amide o-Salicylotoluide. Further, it is involved in the study to check the effect on crystal size with cooling rate in the laboratory. In addition to this, it is used in veterinary medicine and also employed for coating pills, in which the medicine is intended for enteric release salol. ...
Use only if your formulation does NOT contain salicylates. Pepto-Bismol® should not be used in cats since it contains salicylates, the active ingredient in aspirin. Cats are very sensitive to aspirin so it should be avoided. WARNING - PLEASE NOTE THAT THE NEW FORMULATIONS OF KAOPECTATE MAY ALSO HAVE SALICYLATES. Do not use if your formulations lists salicylates as an active ingredient. Any vomiting or diarrhea that persists for more than 24 hours needs your veterinarian's attention. ...
Menthol (MEN-thol), Methyl Salicylate (METH-il sa-LIS-i-late) Treats pain. This medicine is a topical analgesic. Brand Name(s): AMPlify Relief MM, Analgesic Balm, Bengay Greaseless, Calypxo, Castiva Cooling, Cool Heat, Golden Sunshine Herbal, Golden Sunshine Natural Herbal Pain Terminator, Good Neighbor Pharmacy Muscle Rub, Good Sense Cool N...
Author: Allen Loyd V Jr, Year: 2015, Abstract: A formulation for preparing Physostigmine Salicylate 1-mg/mL Injection. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
These goods are effortless to stop. Ironically, items that explicitly listing fragrance chemical substances might be more durable for a buyer to evaluate. Take into consideration a product that lists butylphenyl methylpropional but not fragrance during the ingredient label. Unless customers know that butylphenyl methylpropional is often a fragrance chemical, they may mistakenly believe which the merchandise is fragrance no cost. Danger notion provides An additional dimension to the problem of chemical synonymy. Specifically, customers may well pick click here to find out more out an item that lists wintergreen oil being an ingredient as an alternative to one which lists methyl salicylate because the merchandise with wintergreen oil would seem much more "pure," in spite of The reality that wintergreen oil and methyl salicylate are synonymous in PubChem ...
TY - JOUR. T1 - Amino acids protect epithelial cells from local toxicity by absorption enhancer, sodium laurate. AU - Yata, Takashi. AU - Endo, Yoko. AU - Sone, Miki. AU - Ogawara, Ken Ichi. AU - Higaki, Kazutaka. AU - Kimura, Toshikiro. PY - 2001. Y1 - 2001. N2 - To develop the safe absorption-enhancing formulation attenuating the local toxicity caused by an absorption enhancer, sodium laurate (C12), the effects of amino acids on the local toxicity by C12 were examined in rats. The absorption of phenol red, an unabsorbable marker drug, was significantly enhanced by 10 mM C12 in an in situ colon loop study and the addition of L-glutamine (L-Gln), L-arginine, or L-methionine at 10 mM did not change the promoting effect of C12. However, C12 significantly increased the elution of phospholipids, total protein, and lactate dehydrogenase, which are markers for local toxicity, from colon, but these amino acids attenuated the local toxicity caused by C12 significantly. Transport study using an ...
Kidney or liver disease. High blood pressure. Heart disease. Congestive heart failure. Gout. Nasal polyps The concomitant use of aspirin and certain drugs may cause bruising or a tendency to bleed easily. Some of those drugs include antidepressants such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor); blood thinners such as warfarin; and other salicylates such as choline salicylate, magnesium salicylate, or salsalate. A safe way for older adults to use aspirin is to take it with a full glass of water. To avoid stomach upset, aspirin can be taken with food or milk. Many doctors recommend taking enteric-coated aspirin, which is designed to be gentle on the stomach, but it should be taken with food or milk as well. Extended-release aspirin is also available. Enteric-coated aspirin and extended release aspirin should be swallowed whole and never chewed, crushed, or ...
The normal treatment for flu is rest and plenty of liquids. Treatment also includes ways to prevent spreading the flu virus, such as proper handwashing, keeping common surfaces clean, and coughing or sneezing into your arm or sleeve.. Medications for specific symptoms can help. Cough suppressants can be used for cough. Acetylsalicylic acid* (ASA), ibuprofen, or acetaminophen can be used to treat symptoms of the flu, such as aches and fever. Children and teenagers with flu shouldnt take ASA or other salicylates (medications related to ASA, such as salsalate or magnesium salicylate). The combination of influenza and ASA is linked to Reyes syndrome, a rare but serious condition affecting the brain and liver. Many over-the-counter cold medications contain ASA or other salicylates. Ask your doctor or pharmacist about this.. Antibiotics are not effective against viral infections like flu and the cold, but they are prescribed for complications such as bacterial infections.. Antiviral medications are ...
Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and ...
I get this when I am exposed to salicylates (ie. aspirin, NSAIDs, spices, berries, mint etc) as I am salicylate intolerant. Not sure what else can cause it for people though.The swelling is referred to as andgioedema:http://en.wikipedia.org/wiki/AngioedemaYou may wish to make a note what you have eaten, drunk and worn (lipstick, perfume etc) in the past couple of days each time you have a reaction - you may see a pattern emerge. Unlike allergies (which the reaction is often within 20 min of contact with the allergen) food intolerances can take anywhere up to 48hrs to emerge as a symptom. The other important difference between an allergy and an intolerance is that intolerances are dependent on the amount of exposure to the offending substance and can build up over time in your system. I usually find that if I have a salicylate laden dinner I wake with a swollen face in the morning. Major reactions usually happen around 4:30am for me and are often rapid in their onset - I think it is probably ...
The US Food and Drug Administration (FDA) is encouraging health care providers to report adverse events involving over-the-counter (OTC) topical muscle and joint pain relievers to the FDA MedWatch program. Last week, FDA alerted the public that certain OTC products that are applied to the skin for the relief of mild muscle and joint pain have been reported to cause rare cases of serious skin injuries, ranging from first- to third-degree chemical burns, where the products were applied. These OTC topical muscle and joint pain relievers are available as single- or combination-ingredient products that contain menthol, methyl salicylate, or capsaicin. Based on the reported cases, the majority of second- and third-degree burns occurred with the use of products containing menthol as the single active ingredient, and products containing both menthol and methyl salicylate in concentrations greater than 3% menthol and 10% methyl salicylate.. The various formulations include creams, lotions, ointments, and ...
Introduction. The Commercial Importance of Aspirin Introduction In 1899 Aspirin was first synthesised, and also known as acetylsalicylic acid which is the salicylate ester of ethnic acid. Salicylate origins lie in the naturally occurring compound salicin. It was discovered by the Greeks, around the fifth century B.C, that a substance in the bark of the willow tree, (we now know as salicin) could relieve pain. How does Aspirin work in the body? Aspirin is able to block the production of a substance called prostaglandins. These prostaglandins are produced by the body whenever a cell in the body is injured. Production and release of these prostaglandins leads to swelling, pain and fever which are commonly associated with injuries or disease. Medical uses of Aspirin There are so many medical uses of Aspirin, like: * It is known that aspirin reduces the risk of strokes in patients with early warning signs of Transient Ichaemic attacks. * It is now accepted as an important weapon in the prevention of ...
Cold and Flu: Treating and preventing the seasonal flu. The normal treatment for flu is rest, plenty of liquids, and ASA, ibuprofen, or acetaminophen* to fight fever. Children and teenagers with flu shouldnt take acetylsalicylic acid (ASA) or other salicylates (medications related to aspirin, such as salsalate or magnesium salicylate). The combination of influenza and ASA is linked to Reyes syndrome, a rare but serious condition affecting the brain and liver.
Indomethacin has prominent anti-inflammatory and anti-pyretic properties in experimental animals similar to those of the salicylates. Comparable effects have been demonstrated in man. The anti-inflammatory effects of indomethacin are evident in patients with rheumatoid and other types of arthritis and in acute gout. Although indomethacin is more potent than aspirin, the anti-inflammatory effects of tolerated doses of indomethacin in rheumatoid arthritis are not superior to those of salicylate. Whether indomethacin has analgesic properties distinct from its anti-inflammatory effects remains uncertain. However, in patients with acute post-operative and post-traumatic pain of mild to moderate intensity, single doses of indomethacin provide relief approximately equivalent to that of 600 mg of aspirin. The antipyretic effect of indomethacin has also been readily demonstrated in patients with fever. Single doses of indomethacin are usually adequately tolerated; however, because of its potential ...
There are tons of tinnitus remedies you can get online, but you need to be really mindful in choosing what to utilize. Ensure that your tinnitus solution doesnt have any hazardous side impacts. If you are dealing with ringing in the ears signs, there should be something like an ear infection, wax accumulation, nasal allergies, an international things dislodge in your ear, or a moderate overdose from salicylate thats triggering the pain. If your ringing in the ears is dued to salicylates or medication like aspirin, the buzzing ought to stop once the drug is ceased.. You also might wish to attempt some organic teas for tinnitus relief. Teas that have been understood to stop calling ears are fenugreek, mistletoe, and sunflower hull teas.. In the prevention area and reduction of further damage, preventing loud noise circumstances is extremely important. Earphones and cell phones can sometimes be too loud and even just one quick circumstances of loudness can do the damage. Beware making use of ...
The effects of aspirin, salicylic acid and gentisic acid on the paw swellings in the arachidonic acid-potentiated and in the conventional carrageenan-induced oedema tests as well as on the content of...
Cyclomethycaine. Aspirin. Aluminum Glycinate. Magnesium Carbonate. Acetaminophen. Aspirin. Caffeine. Acetaminophen. Acetaminophen. Acetaminophen. Dihydroxyaluminum Sodium Carbonate. Magnesium Carbonate. Aspirin. Phenacetin. Caffeine. Acetaminophen. Acetaminophen. Acetaminophen. Acetaminophen. Acetaminophen. Choline Salicylate. Choline Salicylate. Glycerylguaiacolate. Aspirin. Phenyltoloxamine Dihydrogen Citrate. ...
The healthier the scalp, the healthier and more beautiful your hair. Aloe Vera contains choline salicylate, mucopolysaccharides, and choline. Choline moisturizes your scalp and prevents the skin from irritating. Mucopolysaccharides improve blood circulation as well as moisturize the scalp. And choline salicylate can reduce swelling and irritation due to its anti-inflammatory properties. All these nutrients act together to ensure the healthier scalp and, consequently, healthy-looking hair. ...
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWGs strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
Polyanhydrides which degrade into biologically active salicylates and alpha-hydroxy acids and methods of using these polyanhydrides to deliver the salicylates and alpha-hydroxy acids to a host are provided.
6H-Dibenz[c,e][1,2]oxaphosphorin,2,4-dibromo- 6-hydroxy-,6-oxide,potassium salt 2,2,2-trichloro-N-(4-methoxyphenyl)acetamide (E)-3-Hexenyl salicylate 2-((1-Oxooctyl-1-13C)oxy)-1,3-propanediyl octadecanoate 7-Aza-5-azoniaspiro[4.5]decane Cobalt (3+), hexaammine-, (OC-6-11)-, salt with iodoic acid (HIO3) (1:3) Axisothiocyanate 4 Phenol, o-[N-(p-hydroxyphenyl)formimidoyl]- 1,1,4-triethyl-2,4-diaza-1-azoniacyclopentane-3,5-dione 2-Ethyl-2-(p-fluorophenyl)-1,3-dithiolane
Pain in the sow around and after farrowing is a welfare-parameter given more and more attention, also because it has been demonstrated that, there is a positive correlation between the use of a pain killer and piglet survival (1).This danish investigation (1)focus on pain produced by aftercontractions of the uterus, so that oxytocin needed to press the milk from the alveoli also induce contractions of the uterus which can cause pain especially in elder sows with a stronger and thicker myometrium that younger sows. However there was a large variation between herds in the effect of the NSAID used, namely meloxicam injectable. Many herdsmen also find it difficult and time-consuming to inject the sows or give meloxicam orally with a drench gun. So the hypothesis was to evaluate the effect of a cheap and safe and easy to administer NSAID in the form of soluble sodiumsalicylate(Sodilin®80%, Dopharma, Netherlands) in the trough after farrowing. Withdrawal period of Sodilin® is zero days.. Materials ...
Aspirin also known as acetylsalicylic acid is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin also has an antiplatelet, or "anti-clotting", effect and is used in long-term, low doses to prevent heart attacks, strokes and blood clot formation in people at high risk for developing blood clots. It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue ...
For almost 100 years the salicylates [aspirin family of drugs] have retained their preeminent position" Goodman and Gilman Pharmacology, 11th Ed, 2006, p. 692. "It is the standard against which all rheumatoid arthritis medication should be measured" supra 690. 3.5 gram is the recommended dose--Merck Manual 1987, p. 960, and same in earlier editions. In 1958 production peaked at 20,000 tons (3 lb. per person). In the late 50s aspirins share of sales fell to the heavily-marketed newer NSAIDs. Following the 1973 discovery that aspirin reduces the incidence of heart attacks (MIs) by reducing blood clotting (thrombi) that completes occlusion of a coronary artery when plaque is leaked. By the 1980s it regained its number 1 position, but too low a dose for prevent of cancer, CVD, etc. "Even at 1300 mg/d, [long-term] 8% of subjects were resistant" AHA to its anticoagulant action (MI protection). Its biological half-life is dose dependent---2-3 hours for low dose and up to 15-30 hours for large doses. ...
11 hydroxycorticosteroids | Inhibition of bone growth by sodium salicylate.  11 hydroxycorticosteroids | Inhibition of bone growth by sodium salicylate.
11 hydroxycorticosteroids. Antinuclear Antibody Screen (ANA); Anti Strptolysin-O (ASO); Calcium (Ca); Chem 6 [Blood Urea ...
more infohttp://lks.stoynev.us/11-hydroxycorticosteroids.html
17-ketosteroids - What does 17-ketosteroids stand for? The Free Dictionary  17-ketosteroids - What does 17-ketosteroids stand for? The Free Dictionary
17-hydroxycorticosteroids. *17-hydroxycorticosteroids test. *17-hydroxylase. *17-hydroxylase deficiency syndrome. *17- ...
more infohttps://acronyms.thefreedictionary.com/17-ketosteroids
11-Hydroxycorticosteroids - Exposure Studies | CTD  11-Hydroxycorticosteroids - Exposure Studies | CTD
In an experimental situation, ambient coarse particulate matter (and its biological constituents of endotoxin and beta-1,3-D-glucan) may influence neural biomarker levels that reflect perturbations of blood-brain barrier integrity and systemic stress response in volunteers ...
more infohttp://ctd.mdibl.org/detail.go?type=chem&acc=D015062&view=expStudies
Hydroxycorticosteroids - Wikipedia  Hydroxycorticosteroids - Wikipedia
Hydroxycorticosteroids (OHCSs) are corticosteroids that have an additional hydroxy (-OH) group. There are two main positions ... 11-hydroxycorticosteroids (11-OHCSs) include: aldosterone corticosterone hydrocortisone 17-hydroxycorticosteroids (17-OHCSs) ... where the hydroxy group may be added: at carbon atom 11, and at carbon atom 17. ...
more infohttps://en.wikipedia.org/wiki/Hydroxycorticosteroids
List of MeSH codes (D06) - Wikipedia  List of MeSH codes (D06) - Wikipedia
17-hydroxycorticosteroids MeSH D06.472.040.585.478.195 --- cortisone MeSH D06.472.040.585.478.225 --- cortodoxone MeSH D06.472. ... hydroxycorticosteroids MeSH D06.472.040.585.353 --- 11-hydroxycorticosteroids MeSH D06.472.040.585.353.118 --- aldosterone MeSH ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D06)
Cortisol:corticosterone ratio | definition of cortisol:corticosterone ratio by Medical dictionary  Cortisol:corticosterone ratio | definition of cortisol:corticosterone ratio by Medical dictionary
Looking for online definition of cortisol:corticosterone ratio in the Medical Dictionary? cortisol:corticosterone ratio explanation free. What is cortisol:corticosterone ratio? Meaning of cortisol:corticosterone ratio medical term. What does cortisol:corticosterone ratio mean?
more infohttps://medical-dictionary.thefreedictionary.com/cortisol%3Acorticosterone+ratio
15N | definition of 15N by Medical dictionary  15N | definition of 15N by Medical dictionary
17-hydroxycorticosteroids. *17-hydroxycorticosteroids test. *17-hydroxylase deficiency syndrome. *17-ketoandrosterone. *17- ...
more infohttps://medical-dictionary.thefreedictionary.com/15N
Aldosterone - DrugBank  Aldosterone - DrugBank
Hydroxycorticosteroids. *Mineralocorticoids. *P-glycoprotein/ABCB1 Inducers. *P-glycoprotein/ABCB1 Substrates. *Pregnanes. * ... Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 3-oxo delta-4-steroids / 11-beta-hydroxysteroids / ... Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the ... Steroid 11-beta-monooxygenase activity. Specific Function. Preferentially catalyzes the conversion of 11-deoxycorticosterone to ...
more infohttps://www.drugbank.ca/drugs/DB04630
Mosquito-borne arboviruses in Australia: - filmtrap info  Mosquito-borne arboviruses in Australia: - filmtrap info
11-hydroxycorticosteroids, blood gases and pH. Immunobloting analysis demonstrated a strong increase of Cyclin D1 protein ...
more infohttp://filmtrap.info/mosquito-borne-arboviruses-in-australia/
3,5-tetrahydroaldosterone sulfate
      - THAS
     Summary Report | CureHunter  3,5-tetrahydroaldosterone sulfate - THAS Summary Report | CureHunter
Hydroxycorticosteroids: 7*11-Hydroxycorticosteroids: 50*Aldosterone: 8566*3,5-tetrahydroaldosterone sulfate: 180 ... 11/01/2015 - "A total of 42,438 primary THAs were available for analysis of revision outcomes and 22,237 for dislocation. ". ... 11/01/2015 - "The purpose of this study was to evaluate the risk of aseptic revision, septic revision, and dislocations for ... 11/25/2015 - "A total of 465 consecutive primary THAs with a posterolateral approach were performed in patients with primary ...
more infohttp://www.curehunter.com/public/keywordSummaryC065339-3-5-tetrahydroaldosterone-sulfate-THAS.do
System among the corticosteroids | Journal of The Royal Society Interface  System among the corticosteroids | Journal of The Royal Society Interface
1999 The type I and type II 11 beta-hydroxysteroid dehydrogenase enzymes. J. Steroid Biochem. Mol. Biol. 69, 391-401. doi: ... This type of contrast is shown in all the 11β-hydroxy versus 11-keto steroids studied here. Also shown are the geometries taken ... Despite this, the 11-ketone compounds may not achieve appropriate configurations for activity, because their C ring flexibility ... The identification of 11-deoxycorticosterone as a specific mineralocorticoid follows the received view in numerous reviews and ...
more infohttp://rsif.royalsocietypublishing.org/content/early/2011/05/20/rsif.2011.0183
Emotional stability during a chamber saturation dive to 49.5 atmospheres absolute  Emotional stability during a chamber saturation dive to 49.5 atmospheres absolute
... and 17-hydroxycorticosteroids (OHCS) determined predive and at 10 intervals during the dive. The mood inventory indicated ...
more infohttps://insights.ovid.com/japsy/197910000/00004565-197910000-00012
Treatment Tracker | Hydroxycorticosteroids, 17 (adrenal gland hormone) level  Treatment Tracker | Hydroxycorticosteroids, 17 (adrenal gland hormone) level
Hydroxycorticosteroids, 17 (adrenal gland hormone) level. Service Code: 83491, Service Type: Medical ...
more infohttps://projects.propublica.org/treatment/uniqservices/83491
081. DDT (FAO/PL:1967/M/11/1)  081. DDT (FAO/PL:1967/M/11/1)
Urinary 17-ketosteroids and 17-hydroxy-corticosteroids were decreased and plasma 17-hydroxy-corticosteroids were slightly ... Urinary 17-hydroxy-corticosteroids were reduced in both cases; however, plasma 17-hydroxy-corticosteroid levels and cortisol ... The DDT content of adipose tissue in mice of the F3, F4 and F5 generations was 0.7 - 2 ppm in the controls and 5 -11 ppm in the ... FAO/PL:1967/M/11/1 WHO/Food Add./68.30 1967 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD THE MONOGRAPHS The content of this ...
more infohttp://inchem.org/documents/jmpr/jmpmono/v067pr07.htm
Non steroidogenic | Neurosteroid biosynthesis: genes for adrenal steroidogenic.  Non steroidogenic | Neurosteroid biosynthesis: genes for adrenal steroidogenic.
The focus on the refinement, reduction and replacement of animal use in toxicity testing requires the development of cell-based systems that mimic the effects of xenobiotics in human tissues. The human adrenocortical carcinoma cell line, H295R, has been
more infohttp://lks.stoynev.us/non-steroidogenic.html
Androgens and the breast | Breast Cancer Research | Full Text  Androgens and the breast | Breast Cancer Research | Full Text
11.. Birrell SN, Bentel JM, Hickey TE, Ricciardelli C, Weger MA, Horsfall DJ, Tilley WD: Androgens induce divergent ... Breast Cancer Research volume 11, Article number: 212 (2009) Cite this article ... Bulbrook RD, Thomas BS, Utsunomiya J, Hamaguchi E: The urinary excretion of 11-deoxy-17-oxosteroids and 17-hydroxy- ... 11]. Breast cancer cell lines and tissue specimens express the enzymes involved in DHT as well as estradiol synthesis. In a ...
more infohttps://0-breast--cancer--research-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/bcr2413
CHRONIC USE OF OPIOIDS AND ANTIPSYCHOTIC DRUGS: SIDE EFFECTS, EFFECTS ON ENDOGENOUS
OPIOIDS, AND TOXICITY *  CHRONIC USE OF OPIOIDS AND ANTIPSYCHOTIC DRUGS: SIDE EFFECTS, EFFECTS ON ENDOGENOUS OPIOIDS, AND TOXICITY *
... with increased urinary excretion of 17-hydroxycorticosteroids indicating the normal release of increased amounts of ... doses over a 24-hour period and response was determined by measurement of urinary excretion of 17-hydroxycorticosteroids, which ... The clinical side effects of the tricyclic antidepressant drugs such as imipramine and amitriptyline are usually mild (Table 11 ... 11, 12 It has been shown that 10%-12% of adult and adolescent methadone-maintained patients are chronic carriers of hepatitis B ...
more infohttp://druglibrary.org/schaffer/heroin/methadone/toxicity.htm
Lyphochek® Quantitative Urine Quality Control | Clinical Diagnostics | Bio-Rad  Lyphochek® Quantitative Urine Quality Control | Clinical Diagnostics | Bio-Rad
Control containing a comprehensive analyte menu for quantitative assays that monitor the precision of tests for general urine chemistry, biogenic amines, and hormones; contains hCG (Pregnancy) and Microalbumin
more infohttp://www.bio-rad.com/en-us/product/lyphochek-quantitative-urine-quality-control
What does 11-deoxycorticosterone mean?  What does 11-deoxycorticosterone mean?
Definition of 11-deoxycorticosterone in the Definitions.net dictionary. Meaning of 11-deoxycorticosterone. What does 11- ... deoxycorticosterone mean? Information and translations of 11-deoxycorticosterone in the most comprehensive dictionary ... Discuss these 11-deoxycorticosterone definitions with the community:. Word of the Day. Would you like us to send you a FREE new ... What does 11-deoxycorticosterone mean?. Definitions for 11-deoxycorticosterone. Here are all the possible meanings and ...
more infohttp://www.definitions.net/definition/11-deoxycorticosterone
Genova Diagnostics Complete Hormones  Genova Diagnostics Complete Hormones
17-Hydroxy-corticosteroids (Total). *Androsterone. *Etiocholanolone. *11-Hydroxy-androsterone. *11-Hydroxy-etiocholanolone. *11 ...
more infohttps://www.integrativepsychiatry.net/genova_diagnostics_complete_hormones.html
  • During a period of IS years from 1975 to 1989, eleven children with adrenocortical tumors were managed with relatively favorable results in our center. (ac.ir)