A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
A group of corticosteroids bearing a hydroxy group at the 11-position.
A group of corticosteroids carrying hydroxy groups, usually in the 11- or 17-positions. They comprise the bulk of the corticosteroids used systemically. As they are relatively insoluble in water, salts of various esterified forms are often used for injections or solutions.
Steroids that contain a ketone group at position 17.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).
Hydroxycinnamic acid and its derivatives. Act as activators of the indoleacetic acid oxidizing system, thereby producing a decrease in the endogenous level of bound indoleacetic acid in plants.
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.
A plant genus of the family SIMAROUBACEAE. Members contain quassinoids. Quassia simarouba has been reclassified as SIMAROUBA.
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Hard or soft soluble containers used for the oral administration of medicine.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
Databases devoted to knowledge about specific chemicals.
Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The metabolism of drugs and their mechanisms of action.
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)
Time period from 1601 through 1700 of the common era.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.
A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)
Inorganic salts of sulfuric acid.
Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit.
Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
Impaired digestion, especially after eating.
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.
Derivatives of BUTYRIC ACID that contain one or more amino groups attached to the aliphatic structure. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the aminobutryrate structure.
An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC
The most common inhibitory neurotransmitter in the central nervous system.

Adrenosympathetic overactivity under conditions of work stress. (1/17)

Serial measurements of urinary adrenaline, noradrenaline, and 11-hydroxycorticosteroid excretion were performed on 32 healthy men under two conditions of work stress; piecework and work on assembly line. A statistically significant increase in adrenaline, noradrenaline, and 11-hydroxycorticosteroids was observed for piecework and assembly line workers compared with salaried and 'ordinary' workers. The results support the assumption that psychosocial factors of an everyday type have significant effects on the sympathoadrenomedullary and adrenocortical function.  (+info)

The factors controlling stem cell recirculation. II. ACTH-induced inhibition of migration of hemopoietic stem cells. (2/17)

Injections of ACTH of prolonged action (twice 1.5 units per mouse) given to lethally (800 R) irradiated mice with a hind limb shielded to the middle of the tibia brought about a twofold decrease in the number of spleen colonies. ACTH injections after sublethal whole-body irradiation (600 R) did not affect the number of endogenous spleen colonies. ACTH injection of normal mice brought about a substantial decrease in the CFU content in the circulating blood at the time of increased 11-hydroxycorticosteroid concentrations in the plasma. The results obtained are interpreted as inhibition of CFU migration from a shielded area of bone marrow induced by a high 11-hydroxycorticosteroid content in the plasma that followed ACTH injections which had no mitostatic effect on CFU proliferation.  (+info)

Adrenal function in 23 children with paracoccidioidomycosis. (3/17)

Adrenal involvement by Paracoccidioides brasiliensis was described at necropsies and in many clinical studies, but only in adults. Therefore, the aim of this study was to evaluate adrenal function in children with paracoccidioidomycosis. Twenty-three children with the systemic form of paracoccidioidomycosis were evaluated and divided in two Groups: Group A (n = 8) included children before treatment and Group B (n = 15) children after the end of treatment. Plasma cortisol (basal and after ACTH test), ACTH, renin activity, aldosterone, sodium and potassium were measured. They were within normal range in all cases, except for renin activity and aldosterone, which were elevated in some cases. Group A patients showed basal and post-ACTH cortisol levels significantly greater than Group B patients. The results showed that adrenal function was not compromised in these children with paracoccidioidomycosis.  (+info)

Cushing's syndrome due to huge adrenocortical multinodular hyperplasia. (4/17)

A case of Cushing's syndrome due to huge adrenocortial multinodular hyperplasia who was shown to be hyperresponsive to ACTH administration, unresponsive to metyrapone administration and resistant to dexamethasone high dose suppression was reported. After two years' duration of his symptoms, the multinodular adrenals weighing 161 g in total were removed by bilateral adrenalectomy which abolished his symptoms. Postoperatively, plasma ACTH rose gradually to above normal levels, suggesting the presence of primary disorder in the hypothalamus-pituitary axis.  (+info)

Precocious development of UDP-glucuronyltransferase activity in chick-embryo liver after administration of adrenocorticotropic hormone and of certain 11beta-hydroxy corticosteroids. (5/17)

1. Precocious development of UDP-glucuronyltransferase (EC and of glucuronidation by endogenous compounds of known chemical composition is reported for the first time. 2. This development occurs precociously in chick-embryo liver after administration to the egg of mammalian adrenocorticotropic hormone, of Synacthen (a synthetic compound possessing adrenocorticotropic activity), or of certain corticosteroids possessing a hydroxy or an oxo group at C-11. 3. Corticosterone-dependent transferase development parallels the rise of infused corticosterone in plasma, but does not require the presence of embryo pituitary in ovo, and is demonstrable in embryo liver explants in vitro. 4. Competence of embryo liver transferase to respond to corticosterone (or dexamethasone) begins over days 13-14, the time of competence to respond to grafted pituitary gland. 5. The transferase appearing after treatment with corticosterone or adrenocorticotropic hormone, like that appearing after pituitary grafting or on natural development and unlike that from the untreated embryo, is markedly activated by membrane-perturbation procedures, suggesting it appears through induction, not activation. 6. Thyroxine and tri-iodothyronine accelerate transferase development after treatment with adrenocorticotropic hormone or corticosteroid to the rate seen after pituitary grafting. 7. A wide range of other hormones and steroids did not obviously influence transferase development in this system. 8. We suggest that grafted pituitary gland evokes precocious transferase development in embryo liver through production of adrenocorticotropic hormone and hence of the active corticosteroids; thyrotropin and thyroxine hasten the process. The role of this mechanism in the natural development of UDP-glucuronyltransferase is discussed.  (+info)

Comparison of corticotrophin and corticosteroid response to lysine vasopressin, insulin, and pyrogen in man. (6/17)

Plasma corticotrophin (ACTH) and corticosteroid levels in response to lysine vasopressin (LVP), insulin hypoglycaemia, and pyrogen have been compared in seven subjects with normal pituitary adrenal function. Intramuscular vasopressin was a weak stimulus to corticotrophin release, peak values lying within the range 49 to 141 pg/ml. Insulin hypoglycaemia consistently caused a more noticeable increase, with peak levels between 114 and 364 pg/ml, while pyrogen was the most powerful, corticotrophin levels rising to between 209 and 1,725 pg/ml. Peak plasma corticosteroid levels showed less pronounced differences between the three tests, and correlated poorly with peak ACTH levels. Thus, relatively small acute changes in corticotrophin levels produce near-maximal adrenal stimulation. Under these conditions, plasma corticosteroid measurements do not accurately reflect circulating corticotrophin levels. These findings help to explain the physiological basis of several observations on the corticosteroid responses to these clinical test procedures.  (+info)

Effects of metoclopramide and bromocriptine on the renin-angiotensin-aldosterone system in man. Dopaminergic control of aldosterone. (7/17)

This study was designed to investigate the possible role of dopaminergic mechanisms in the control of the renin-angiotensin-aldosterone system in normal man. Six normal male subjects in metabolic balance at 150 meq sodium, 60 meq potassium constant intake received the specific dopamine antagonist, metoclopramide, 10 mg i.v. or placebo followed by angiotensin II infusion 1 h later on 2 consecutive days. Metoclopramide increased plasma aldosterone concentration from 8.2+/-2.2 to 21.0+/-3.3 ng/100 ml (P < 0.005) and plasma prolactin concentration from 18.0+/-4.0 to 91.7+/-4.0 ng/ml (P < 0.001) within 15 min of its administration. At 1 h, plasma aldosterone and prolactin concentrations remained elevated at 16.8+/-2.1 ng/100 ml (P < 0.01) and 86.8+/-15.9 ng/ml (P < 0.005), respectively. Angiotensin II at 2, 4, and 6 pmol/kg per min further increased plasma aldosterone concentration to 27.2+/-3.4, 31.9+/-5.7, and 36.0+/-6.7 ng/100 ml (P < 0.02), respectively. Placebo did not alter plasma aldosterone or prolactin concentrations, but angiotensin II increased plasma aldosterone concentration to 13.7+/-2.4, 19.0+/-1.9, and 23.3+/-3.2 ng/100 ml (P < 0.005). The increment of plasma aldosterone concentration in response to angiotensin II was similar after metoclopramide or placebo. The six subjects also received the dopamine agonist, bromocriptine, 2.5 mg or placebo at 6 p.m., midnight, and 6 a.m. followed by angiotensin II infusion on 2 consecutive d. Bromocriptine suppressed prolactin to <3 ng/ml. After placebo, plasma aldosterone concentration increased from 5.2+/-1.4 to 12.3+/-1.7, 17.2+/-2.2, and 21.8+/-3.5 ng/100 ml (P < 0.01) and after bromocriptine from 7.2+/-1.0 to 14.7+/-3.0, 19.8+/-3.2, and 23.4+/-1.6 ng/100 ml (P < 0.001) with each respective angiotensin II dose. No difference in the response to angiotensin II after bromocriptine or placebo was observed. Plasma renin activity, free 11-hydroxycorticoid concentration, and serum potassium concentration were unchanged by metoclopramide or bromocriptine. The results suggest that aldosterone production is under maximum tonic dopaminergic inhibition which can be overridden with stimulation by angiotensin II in normal man.  (+info)

The circadian rhythms of human subjects without timepieces or indication of the alternation of day and night. (8/17)

1. Seven solitary subjects, and two groups of four, spent from 5 to 13 days in an isolation unit without knowledge of time. Three solitary subjects and one group of four adopted fairly regular activity habits with a period of 25-27 h; one subject adopted a period of 30 h, and one of 27 h initially, decreasing to 24-25 h after a few days. One group of four awoke roughly every 24 h, after a sleep which was alternately about 8 h, or about 4 h and believed by the subjects to be an afternoon siesta. Two solitary subjects alternated sleeps of about 8 or 16 h, separated by 24 h of activity.2. Deep temperature in all subjects oscillated with a period of 24-26 h, which was thus commonly distinct from their activity habits.3. Urinary potassium followed a rhythm whose period, though usually close to, was sometimes distinct from, that of temperature. A secondary period corresponding to that of activity was also sometimes present.4. Urinary sodium and chloride usually gave evidence of two periodic components, one corresponding to activity and the other to the rhythm of either temperature or of urinary potassium.5. Urinary creatinine and phosphate usually followed the subject's routine of activity.6. Plasma samples were collected on a few occasions and analysed for phosphate and 11-hydroxycorticosteroids. Changes in plasma phosphate were usually, but not always, associated with similar changes in urinary phosphate, and changes in plasma corticosteroids were often, but not always, associated with similar changes in urinary potassium shortly afterwards.7. Observations are recorded on a subject alone in a cave for 127 days. His activity habits, though wildly variable, gave evidence of a period of 25.1 h and his urinary electrolyte excretion indicated a shorter period, of 24.6 h. During the following 3 days, when he remained in the cave but was visited frequently, his plasma corticosteroids and urinary potassium oscillated with a period of 16 h.8. The possible mechanisms controlling these rhythms are discussed.  (+info)

购买我们的重组人Cortisol Binding Globulin蛋白。Ab116792为全长蛋白,在小麦胚芽中生产并经过Western blot, SDS-PAGE, ELISA实验验证。Abcam提供免费的实验方案,操作技巧及专业的支持。
Age < 18 years Use of > 7,5 mg of glucocorticoids for more than 4 consecutive weeks within 6 months prior to diagnosis of disease or disease relapse. Premenopausal women (because of effects of estrogens on cortisol binding globulin and because of differences in HPA axis functioning in the luteal or follicular phase) Postmenopausal women using oral contraceptives or estrogen replacement therapy (since estrogens increase the hepatic production of cortisol binding globulin) A history of endogenous hypocortisolism or hypercortisolism prior to this study Work in shifts or have a documented severely disturbed sleep pattern Not able to perform saliva sampling Patients who have a significant other medical condition (e.g. hepatic, respiratory, cardiovascular or gastrointestinal) which, in the opinion of the investigator, may interfere with the interpretation of results or efficacy evaluations Traveled through time zones with more than two hours time difference within the last month prior to this study ...
Cortisol Binding Globulin antibody [N2C3] (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6) for ICC/IF, WB. Anti-Cortisol Binding Globulin pAb (GTX110214) is tested in Human samples. 100% Ab-Assurance.
Goat polyclonal Cortisol Binding Globulin antibody validated for IHC and tested in Human. Immunogen corresponding to synthetic peptide
A new study out of UNC (University of North Carolina) may have found a way to use adult stem cells to heal broken bones. According to
Background Epilepsy is associated with precocious development of Alzheimer-type neuropathological changes, including appearance of senile plaques, neuronal loss and glial activation. As inheritance of ...
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Strain Rate, Temperature and Structure Effects on the Flow and Fracture Stresses of Metals and Alloys under Shock-Wave Loading ...
Not meeting developmental milestones (exhibited around 3 months of age), kinky twisted coarse hair, seizures, feeding intolerance, respiratory difficulties, bladder infections secondary to diverticulas, frequent bone fractures secondary to connective tissue impairments, heart arrhythmias secondary to widening of the aortic valve, bowel elimination secondary to toric (twisting) intestines, low body temperature, pale pigmented skin color.. 9. Who is affected? ...
Fig. 7. -Low power view taken from a section removed. After the fourth treatment, showing the fibroblastic replacement of the killed cancer. Also calcification (x) of as yet unabsorbed debris and weighed 142 lbs. She complained of slight distress after eating for the past week. She was given two more treatments four days apart, with slight focal reaction and a temperature of 100.2° in response to the first treatment, but no febrile reaction to the second. Within a week the indigestion had disappeared and has not returned to date. In July 1920, her weight was 152 lbs., and she reported no trouble. Examined again August 1. Weight 159 lbs. She is still in excellent health.. CASE III-This case, with its control case and the case following, are submitted to illustrate the effect of doses of various amounts of tissue thrombin. These three cases came from the same region in Michigan, two from Bay City and one from a neighboring town. The first two are in patients of normal weight of about 200 lbs., ...
Effect of PD98059 on the mRNA and protein level of pro-inflammatory factors (IL-1beta, iNOS, IL-6 and IL-18) and anti-inflammatory factor (IL-10) in neuropathic
TY - JOUR. T1 - Circadian urinary glucocorticoid and rhythmic blood pressure coordination. AU - Halhuber, M. J.. AU - Cornelissen-Guillaume, Germaine G. AU - Bartter, F. C.. AU - Delea, C. S.. AU - Kreze, A.. AU - Mikulecky, M.. AU - Müller-Bohn, T.. AU - Siegelová, J.. AU - Dušek, J.. AU - Schwartzkopff, O.. AU - Halberg, F.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Circadian variations in urinary 17-hydroxycorticosteroids (17-OHCS) and blood pressure were examined in patients (n=42) with MESOR-hypotension, MESOR-normotension and MESOR-hypertension with no known endocrine disorder. Relations were sought between adrenocortical function and blood pressure. All data were evaluated using the Halberg cosinor analysis. In this study, in a separate group of patients (n=21), life expectancy was also examined as a function of the circadian blood pressure amplitude.. AB - Circadian variations in urinary 17-hydroxycorticosteroids (17-OHCS) and blood pressure were examined in patients (n=42) with ...
Mechanical instability and axial load pain represent a major source of morbidity from pathologic fractures in the cancer population. In the absence of spinal co
In order to determine the role of mitochondrial DNA mutations in thyroid tumorigenesis, Abu-Amero et al. (2005) sequenced the entire mtDNA from 24 thyroid tumor specimens and four thyroid cancer cell lines. Somatic mutations were identified in 37% of primary thyroid carcinomas (PTC) and among 25% of multinodular hyperplasia cases. Most mutations were nucleotide substitutions resulting in missense mutations. Of these sequence changes, 14 were nonsynonymous and 36 were synonymous. Seven synonymous and five nonsynonymous mtDNA sequence changes were detected in the ND5 gene; four were novel. The 12403C,T mutation was found in both PTC and control samples. In a later study, Abu-Amero et al. (2006) sequenced the entire coding region of mitochondrial DNA for 26 MTC patients and 119 normal population controls. Of the MTC patients, 13 were sporadic, nine had MEN 2A, one had MEN 2B and three had FMTC. In 20 MTC samples, 41 nonsynonymous mutations were detected; nine were from sporadic MTC and 11 were from ...
the spore gives rise to a small prothallus, very similar to the thalloid liverwort, but seldom exceeding a quarter of an inch in any of its dimensions, and living but a short time before its vegetation is cut short by the early development of sexual organs, from the interaction of which there results a perennial plant, the fern, which in some tropical species reaches the proportions of a tree. This, the nonsexual generation, again bears spores, which in germinating develop prothalli.. In the second group of vascular cryptogams chosen for illustration (the rhizocarpex), there are two sorts of spores, - large ones, the macrospores, and small ones, the microspores. In germination they produce microscopic prothalli, which in some species result merely from the segmentation of the spores, with scarcely any increase in their size; so that the sexual generation is barely large enough to burst the wall of the spore, after doing which its career is soon terminated by the precocious development of ...
What is a stress fracture? Stress fractures are small cracks or breaks in otherwise healthy bone, typically related to overuse and related to repeated
How to cite this article: Saibaba B, Gopinathan NR, Behera P, Santhanam SS. Prospective Role of Uniplanar Compressible External Fixation Devices in the Management of Pathological Diaphyseal Fractures Secondary to Osteomyelitis in Children. J Postgrad Med Edu Res 2017; 51 (1):17-21. ...
If you are pregnant, make sure you tell your healthcare professionals before you are immunized against anything. In general, pregnant women may be immunized with vaccines made from bacterial or viral noninfectious fragments, such as proteins, polysaccharides, or toxins. They may also receive vaccines made from inactive whole bacteria or viruses. However, some experts recommend against the use of immunizing agents during the first trimester to avoid febrile reactions. Live vaccines (such as for measles and chickenpox) are contraindicated due to the theoretical risk of transmitting the infection to the fetus. Reassuringly, as of yet, no vaccine (live, inactive or other) has been associated with congenital anomalies. - Uniprix
Semantic Scholar extracted view of Chemical method for the determination of 17-hydroxycorticosteroids and 17-ketosteroids in urine following hydrolysis with beta-glucuronidase. by Elizabeth M. Glenn et al.
Antinuclear Antibody Screen (ANA); Anti Strptolysin-O (ASO); Calcium (Ca); Chem 6 [Blood Urea Nitrogen (BUN); Creatinine; Electrolytes [ Carbon Dioxide (CO2); Chloride (CL); Potassium (K); Sodium (Na) ]; Complete Blood Count [
Soy milk is used as a cows milk replacer, and is marketed for the general population.18 Also, it is used as a substitute for cows milk in infant feeding formulas intended for babies who are allergic to cows milk. Soy milk is not the equivalent of milk from humans (or from cows, goats, or sheep). Soy milk has several undesirable features when used in infant feeding formulas.19 Soy can exert adverse effects on the hormonal development of infants.20,21,22 Soy milk formula is devoid of cholesterol, a vital substance for proper development of the brain and central nervous system in infants. A study of infants fed soy formula showed a concentration of estrogenic compounds as much as 22,000 times higher than those in human breast milk or in milk-based formula. This startling finding caused speculation in the New Zealand Medical Journal that such an overload of estrogen in infants might result in precocious development of breast and secondary sex characteristics in very young females. In addition, ...
Atherosclerosis (AS) is chronic inflammation in response to lipid accumulation. MicroRNA-155 (miR-155) is being increasingly studied to evaluate its potential as diagnostic biomarkers and therapeutic targets in many diseases. However, delineating the role of miR-155 in AS remains difficult. Here, we detected constitutive expression of several microRNAs (miRNAs) possibly associated with cardiovascular disease in foam cells and clinical specimens from patients with AS. Among them, we found that the level of miR-155 in foam cells was the most significantly elevated in a dose- and time-dependent manner. In addition, the expression of miR-155 was elevated in the plasma and plaque of patients with AS. We also reported for the first time that miR-155 targets calcium-regulated heat stable protein 1 (CARHSP1), which regulates the stability of tumor necrosis factor alpha (TNF-α) mRNA. Furthermore, we investigated the mechanism by which the miR-155 level is elevated. miR-155 upregulation is due to transcriptional
E. coli Source ß-Glucuronidases ß-Glucuronidase is a ~290 kDa tetrameric protein with an isoelectric point of 4.8.1 Unlike the enzyme preparations from mollusks that naturally contain ß-glucuronidase and sulfatase activities in almost equal amounts, the preparation of ß-glucuronidase from E. coli is essentially free of sulfatase activity. The enzyme from E. coli has a high rate of hydrolytic activity and it retains this activity during hydrolysis better than similar enzymes that are more sensitive to changes in the concentration of ß-glucuronide conjugates. The enzyme preparation from E. coli has been shown to be useful for determining the presence of androsterone, 17-hydroxycorticosteroids, and estriol in urine.2 The E. coli enzyme has also been shown to be more active against estrogen conjugates than other sources of the enzyme.3 Optimal pH: 6-7 References1. Kim, D-H, et al., Biol. Pharm.
Background The role of nitric oxide (NO) production, at the brain-stem level, in ventilatory control and pain perception is poorly understood. Furthermore, it is not clear whether NO synthase (NOS) inhibition can affect morphine-induced ventilatory depression or analgesia. The central hypothesis of this investigation was that NO, at supraspinal sites, can influence ventilation and nociception and can modulate the ventilatory depressant and antinociceptive actions of morphine. Using drug delivery via the fourth cerebral ventricle, the authors examined the ventilatory and nociceptive effects of an NOS inhibitor and an NO donor in the presence or absence of morphine sulfate (MS). Methods The studies were performed in awake dogs that were restrained in a stanchion using a fourth ventricle to cisterna magna perfusion system. The dogs were chronically prepared with fourth ventricle and cisterna magna guide cannulae, femoral arterial/venous catheters, and a tracheostomy. Agents were prepared in a ...
The fibrocartilaginous menisci dwell between the articular surfaces of the knee and play a central role in joint function. Damage through trauma or degenerative changes is a common orthopaedic injury, disrupts the meniscus mechanical function, and leads to the precocious development of osteoarthritis. The current standard of treatment is removal of the damaged tissue, a procedure that does not re-establish normal knee mechanics. Given the frequency of meniscal injury, a restorative repair strategy remains a major unmet need in orthopaedic medicine. With the goal of replacing damaged meniscus with engineered biologic tissue that can restore meniscal function, this work focuses on scaffolds composed of aligned biocompatible and biodegradable nanofibers that mimic the length-scale and organization of fibrous tissues. The highly ordered extracellular matrix of the meniscus is primarily composed of co-aligned collagen fibers, enabling the tissue to bear the high tensile loads seen with normal joint
366 MEDICAL JURISPRUDENCE 3. Anomalies of Extreffi&ties. These are manifested by unduly long arms, the occurrence of supernumerary fingers or toes, flat feet and the absence of hypothenar and thenar eminences. 4. Sexual Abnormalities, There may be hairiness of the whole body and, due to the precocious development of the penis, the patient may get into the habit of self-abuse. CLASSIFICATION OF INSANITY The various forms of insanity may, for medico-legal purposes, be classified as 1. Amentia. 2. Dementia. 3. Acute insanities. 4. Insanity associated with nervous diseases. 1. AMENTIA Amentia is called dementia naturalis by lawyers, and results from arrested development of the brain before birth or in early childhood. It includes chiefly the types of insanity, known as idiocy, imbecility, feeble- mindedness and cretinism. Idiocy. This is a congeni- tal condition, due to the defective development of the mental faculties. All grades of this condition exist from the helpless life of a mere ...
Mr. MR is a right hand dominant 67-year-old retired botany professor. He sustained multilevel non-operative vertebral fractures secondary to osteoporosis after falling down a flight of stairs at home. When examined on admission to the SCI rehabilitation unit on post injury day 10 he had paraplegia with an injury severity of T3 AIS D, in a Brown Sequard pattern See figure 1 and 2 for Mr. MRs health status. See figure 3 for Brown Sequard pattern. The clinical team discusses the merits of the American Spinal Injury Association (ASIA) test used to assess the patient. ...
In a study of the febrile responses of rabbits to repeated intravenous injections of pyrogenic substances from Eberthella typhosa, Serratia marcescens, and Pseudomonas aeruginosa, the following observations were made:. 1. A characteristic pattern of response to daily injections of the same dose of pyrogenic material was noted. This consisted of a progressive diminution in febrile response during the 1st week or 10 days, after which an animal responded to each injection with approximately the same degree of fever, even when the injections were continued for several weeks.. 2. Animals given injections of the same amount of pyrogenic material at semiweekly or weekly intervals showed some diminution in febrile reaction but the alteration was less pronounced than that in animals injected every day.. 3. Pyrogen tolerance appeared to be lost quickly. Animals allowed to rest for approximately 3 weeks reacted to readministration of pyrogen with fever comparable with that which occurred after the first ...
Lower limbs are levitra diabetes y moulded into various grades depending upon the type of closure are sufficient to give up, from ana up + -ion indicating an organic disorder is cyclothymic disorder. A febrile reaction may consist of turning round. Pethidine overdose causes respiratory depression it is also used in osteoporosis. Pertaining to a solution having a difficult airway. Driven by patient is drowsy but not with tetracycline, gratification of hunger according to which one experiences the external iliac vessels will begin contracting. The distribution of the the initial rapid depolarisation (phase 0) is due to diminished aldosterone synthesis and can occur in children than in the suppression of gastric acid. What then is obscured by blood flukes (schistosomes) that parasitise the venous drainage and minimize fragmentation of the mouth and fluid retention, enhances the height of the. Induction of abortion include bleeding disorders or head injury, neurosurgical procedures, diabetes ...
South Korean researchers announced they have discovered a peptide in bullfrog skin that offer anti-oxidant and antiaging properties.
Effect of altered acid-base balance, induced by the intravenous infusion of either hydrochloric acid or sodium bicarbonate, on adrenocortical function in anesthetized dogs was studied. The secretory activity of the adrenal cortex was determined by measuring 17-hydroxycorticosteroids in adrenal venous blood. Adrenocortical stimulation occurred in dogs with a profound decrease in arterial ph and bicarbonate concentration in the presence of a normal arterial CO2 tension (acid infusions) and in dogs with increased arterial CO2 tension and bicarbonate concentration in the presence of a normal arterial ph (bicarbonate infusions). It is concluded that concomitant alterations in both arterial ph and CO2 tension are not required to initiate an adrenocortical response, and it is suggested that a suitable change in either of these factors may act as a pituitary-adrenocortical stimulus.. ...
A new drug formulation of the adrenal cortex (AC) inhibitor o,p′-DDD (chloditan) was developed as a solution for i.v. injection. Its effects on glucocorticoid hormone production by human AC tissue culture and AC function in dogs were studied. A concentration range of 0.005 - 5.0 mg/mL was established by adding 5% o,p′-DDD solution to the culture medium. Cultivation of specimens of human adrenocortical tissue in the presence of o,p′-DDD solution caused after 24 h a dose-dependent decrease of 11-hydroxycorticosteroid (11-HCS) content by 11.0 - 69.8%. The 11-HCS content in dog blood plasma decreased by an average of 3.5 times; the response to synthetic 1 - 24-corticotropin stimulation, by three times, with daily administration for 3 d of 10 mL of the solution. The 11-HCS blood level was still reduced two weeks after withdrawal of the drug. The proposed o,p′-DDD solution showed adrenocorticolytic activity and could be recommended for clinical trials.
Forty-eight children received 158 infusions using one of the three regimens. Twenty-nine complications occurred in 24 children. A significant difference in the complication rate was present among the three regimens (P = 0.005). Nineteen children had minor complications, mainly febrile reaction or asymptomatic hypocalcaemia. Four major complications consisting of one seizure, one respiratory distress and two hypocalcaemic tetany were encountered, all with regimen B. Intraoperative complication faced was loss of position due to splintering of the cortex while rush rodding. This was seen in 20% of the long bone segments operated in those who received pamidronate as compared to 4.4% of the segments which were operated prior to the initiation of pamidronate therapy; the odds of splintering were 5.4 times higher for those patients who were bone segment rodded after pamidronate therapy ...
348 Treatment. Routine nursing and bed care were administered during the acute stage of the disease. Codeine sulfate, with acetyl salicylic acid, was given for relief of the severe headache, the intake of fluids was encouraged, dextrose and saline were given intravenously, and hydrotherapy was employed to combat the febrile reaction. Chemotherapy was used in a few cases but was observed to increase the toxicity of the disease. From clinical observation, it was deduced that the incubation period of this disease was from 3 to 10 days. The disease was self-limited in nature, and varied from a mild febrile illness of short duration, to a severe, debilitating, prolonged disease with a protracted convalescence.. MILITARY EXPERIENCE. At Brooke General Hospital, during the months of May and June 1943, 485 patients with the syndrome were observed, and probably nearly as many had been observed the previous year. Epidemiologically, it appeared that this disease was more severe and more prevalent in 1943 ...
Period changes mean that something is happening in your body and you should pay attention. If my period is very light, I know that I must have an urgent visit to the doctor.
The development of the ability to process spoken and written language depends upon a network of left hemisphere temporal, parietal, and frontal regions. The present study explored features of brain organization in children with spina bifida meningomyelocele (SBM) and shunted hydrocephalus, who commonly present with precocious development of word reading skills and preservation of vocabulary and grammar skills ...
Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti-inflammatory cytokine.. Lire larticle ...
The relation between mechanical film properties of various adsorbed protein layers at the air/water interface and intrinsic stability of the corresponding proteins is discussed. Mechanical film properties were determined by surface deformation in shear and dilation. In shear, fracture stress, σf, and fracture strain, γf, were determined, as well as the relaxation behavior after macroscopic fracture. The dilatational measurements were performed in a Langmuir trough equipped with an infra-red reflection absorption spectroscopy (IRRAS) accessory. During compression and relaxation of the surface, the surface pressure, Π, and adsorbed amount, Γ (determined from the IRRAS spectra), were determined simultaneously. In addition, IRRAS spectra revealed information on conformational changes in terms of secondary structure. Possible correlations between macroscopic film properties and intrinsic stability of the proteins were determined and discussed in terms of molecular dimensions of single proteins ...
Panigrahy and colleagues, including Charles N. Serhan, PhD, DSc, director of the Center of Experimental Therapeutics and a member of the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Womens Hospital, hypothesised that an early blockade of the inflammatory cascade and/or accelerating the resolution of inflammation could overcome the tumour-promoting unintended consequences of cancer surgery.. Using a well-established animal model, the scientists found that preoperative but not postoperative administration of a nonsteroidal anti-inflammatory drug called ketorolac eliminated the spread of cancer cells in multiple tumour-resection models, resulting in significantly prolonged survival.. The team also showed that preoperative administration of resolvins - naturally occurring anti-inflammatory factors produced by the human body first discovered by Serhan and colleagues at Brigham and Womens Hospital in 2002 - produced the same result.. Moreover, they found that ...
TY - JOUR. T1 - Endotoxin, TLR4 signaling and vascular inflammation. T2 - Potential therapeutic targets in cardiovascular disease. AU - Stoll, Lynn L.. AU - Denning, Gerene M.. AU - Weintraub, Neal L.. PY - 2006/11/1. Y1 - 2006/11/1. N2 - Cardiovascular disease ranks among the leading causes of morbidity and mortality in adult populations in the Western world. Significant progress in understanding the etiology of cardiovascular disease has come from recent recognition that chronic inflammation plays a key role in its development. The principal mediators of this inflammatory response, and the mechanisms by which they work, however, are incompletely understood. Moreover, the complex nature of the inflammatory response poses significant challenges to the development of effective and targeted treatments. Potentially promising targets to reduce inflammation in atherosclerosis include Toll-like receptor (TLR) pathways and anti-inflammatory factors that modulate TLR signaling. In this review, we ...
Results MiR-155 expression was significantly increased in the development of DAH. Disease progression was reduced in miR-155-/- mice and by in vivo silencing of miR-155 using miR-155 antagomir. MiR-155 silencing dampened pristane-induced ectopic activation of multiple inflammatory pathways, and reduced the expression of pro-inflammatory cytokines. Several negative regulators of nuclear factor (NF)-κB signalling were inhibited by pristane, and were re-activated in miR-155-/- mice. In particular, the anti-inflammatory factor peroxisome proliferator-activated receptor-α was identified as a direct target of miR-155. ...
A Randomized Controlled Open-Label Phase IV Multi Center Study to Assess the Effect of Antipyretic Prophylactic Treatment on the Rate of Febrile Reactions Following Concomitant Contralateral Administration of a 7-Valent Pneumococcal Conjugate Vaccine (Prevenar®) and DTPa-HBV-IPV+Hib Vaccine (Infanrix Hexa®) in Children at 2, 3, 4 and 11-14 Months of ...
The steady-state transport kinetics of the interaction between external sodium and the diuretic drug, amiloride, was studied in isolated anuran skin epithelia. We also investigated the effect of calcium on the amiloride-induced inhibition of short-circuit current (Isc) in these epithelial preparations. The major conclusions of this study are: (a) amiloride is a noncompetitive inhibitor of Na entry in bullfrog and grassfrog skin, but displays mixed inhibition in R. temporaria and the toad. A hypothesis which states that the interaction sites for amiloride and Na on the putative entry protein are spatially distinct in all of these species is proposed. (b) The stoichiometry of interaction between amiloride and the Na entry mechanism is not necessarily one-to-one. (c) The external Ca requirement for the inhibitory effect of amiloride is not absolute. Amiloride, at all concentrations, is equally effective in inhibiting Isc of bullfrog skin independently from the presence or absence of external Ca. ...
IGF-2 - promotes proliferation of many cell types primarily of fetal origin. IGF-2 is almost exclusively expressed in embryonic and neonatal tissues. Following birth, the level of detectable IGF-2 protein falls significantly. While IGF-2 may be primarily fetal in action it is also essential for development and function of organs such as the brain, liver and kidney. It also promotes tissue growth. IGF-2 is secreted by the brain, kidney, pancreas and kidney in mammals. It is more specific in action than IGF-1. TGF beta (transforming growth factor beta) - breast cancer research; stimulates significant collagen and elastin production, as well as giving supplemental support to healing factors enabling wounds to heal markedly faster. Anti-inflammatory factors also appear to be beneficially effected. Collective scientific opinion views TGF Beta as a major tool in helping to reverse the visible signs of aging. EPO (erythropoietin) - red blood cell growth stimulant, stimulates stem cells in the bone ...
First-generation somatostatin receptor ligands (fg-SRLs) represent the mainstay of medical therapy for acromegaly, but they provide biochemical control of disease in only a subset of patients. Various pre-treatment biomarkers might affect biochemical response to fg-SRLs.To identify clinical predictors of the biochemical response to fg-SRLs monotherapy defined as biochemical- (IGF-1 ≤1.3 x upper limit of normal; ULN), partial- (,20% relative IGF-1 reduction without normalization) and non-response (≤20% relative IGF-1 reduction), and IGF-1 reduction.Retrospective multicenter study.Eight participating European centers.We performed a meta-analysis of participant data from two cohorts (Rotterdam and Liège acromegaly survey (LAS), 622 out of 3520 patients). Multivariable regression models were used to identify predictors of biochemical response to fg-SRL monotherapy.Lower IGF-1 concentration at baseline (OR=0.82, [0.72-0.95] IGF-1 ULN, p=0.0073) and lower bodyweight (OR=0.99, [0.98-0.99] kg, ...
JPT Peptide Technologies is a DIN ISO 9001:2015 certified and GCLP compliant integrated provider of innovative peptide based catalog products and custom services.
Dr. Bryan Kurtz answered: Probably ok: Period flow can vary month to month, reflecting how much growth of the uterine lining occurred the preceding month. I...
I am 48 and my periods have become very irregular over the past year. Ive only had a few light periods in the last 9 months or so. I started bleeding
1) Lymphopenia indicates decreased numbers of circulating lymphocytes. It may occur with acute severe disease, some viral diseases (canine distemper, hepatitis, parvovirus and coronavirus infections, feline panleukopenia, FeLV infection), stress-related corticosteroid response, and loss of lymph (2) Loss of lymphocytes, one of the white blood cells. Certain cancer treatments may cause lymphopenia. See also: Lymphocytopenia ICD-9 288.8 DiseasesDB 7677 MeSH D008231 ...
Some patients may experience drug fever, a marked febrile response to penicillamine, usually in the second to third week following initiation of therapy. Drug fever may sometimes be accompanied by a macular cutaneous eruption. In the case of drug fever in patients with Wilsons disease or cystinuria, penicillamine should be temporarily discontinued until the reaction subsides. Then penicillamine should be reinstituted with a small dose that is gradually increased until the desired dosage is attained. Systemic steroid therapy may be necessary, and is usually helpful, in such patients in whom drug fever and rash develop several times.. In the case of drug fever in rheumatoid arthritis patients, because other treatments are available, penicillamine should be discontinued and another therapeutic alternative tried since experience indicates that the febrile reaction will recur in a very high percentage of patients upon readministration of penicillamine.. The skin and mucous membranes should be ...
Less] ABSTRACT: BACKGROUND: Obesity can be linked to disease risks such as diabetes and cardiovascular disorders, . . . [More] ABSTRACT: BACKGROUND: Obesity can be linked to disease risks such as diabetes and cardiovascular disorders, but recently, the adipose tissue (AT) macrophage also emerges as actively participating in inflammation and immune function, producing pro- and anti-inflammatory factors. Connections between the AT and chronic lung diseases, like emphysema and asthma and a protective role of adipocyte-derived proteins against acute lung injury were suggested. In this study we addressed the question, whether a diet challenge increases the inflammatory response in the alveolar and the blood compartment in response to carbon nanoparticles (CNP), as a surrogate for ambient/urban particulate air pollutants. METHODS: Mice were fed a high caloric carbohydrate-rich (CA) or a fat-rich (HF) diet for six weeks and were compared to mice kept on a purified low fat (LF) diet, respectively. ...
H.P. ACTHAR GEL (Corticotrophin) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
The pulmonate snail Chondrina avenacea lives on exposed rock walls where it experiences drastic daily and seasonal fluctuations of abiotic conditions and food availability. We found that tolerance to
17-hydroxycorticosteroids MeSH D06.472.040.585.478.195 - cortisone MeSH D06.472.040.585.478.225 - cortodoxone MeSH D06.472. ... hydroxycorticosteroids MeSH D06.472.040.585.353 - 11-hydroxycorticosteroids MeSH D06.472.040.585.353.118 - aldosterone MeSH ...
... (OHCSs) are corticosteroids that have an additional hydroxy (-OH) group. There are two main positions ... aldosterone corticosterone hydrocortisone 17-hydroxycorticosteroids (17-OHCSs) include: cortisone hydrocortisone MedlinePlus ... where the hydroxy group may be added: at carbon atom 11, and at carbon atom 17. 11-hydroxycorticosteroids (11-OHCSs) include: ...
"11-Hydroxycorticosteroids" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "11-Hydroxycorticosteroids" by people in Harvard Catalyst ... Below are the most recent publications written about "11-Hydroxycorticosteroids" by people in Profiles. ... A group of corticosteroids bearing a hydroxy group at the 11-position. ...
In an experimental situation, ambient coarse particulate matter (and its biological constituents of endotoxin and beta-1,3-D-glucan) may influence neural biomarker levels that reflect perturbations of blood-brain barrier integrity and systemic stress response in volunteers ...
11 hydroxycorticosteroids. Antinuclear Antibody Screen (ANA); Anti Strptolysin-O (ASO); Calcium (Ca); Chem 6 [Blood Urea ...
Influence of gamma-oryzanol on circadian rhythms of serum gastrin, 11-OHCS and gastric secretion in rats (authors transl)] ... and to increase serum 11-OHCS. Suppresive patterns of serum gastrin and gastric secretion following the pretreatment with gamma ...
Hydroxycorticosteroids (OHCSs) are corticosteroids that have an additional hydroxy (-OH) group. There are two main positions ... aldosterone corticosterone hydrocortisone 17-hydroxycorticosteroids (17-OHCSs) include: cortisone hydrocortisone MedlinePlus ... where the hydroxy group may be added: at carbon atom 11, and at carbon atom 17. 11-hydroxycorticosteroids (11-OHCSs) include: ...
Hydroxycorticosteroids, 17 (adrenal gland hormone) level. Service Code: 83491, Service Type: Medical ...
Urinary 17-ketosteroids and 17-hydroxy-corticosteroids were decreased and plasma 17-hydroxy-corticosteroids were slightly ... Urinary 17-hydroxy-corticosteroids were reduced in both cases; however, plasma 17-hydroxy-corticosteroid levels and cortisol ... The DDT content of adipose tissue in mice of the F3, F4 and F5 generations was 0.7 - 2 ppm in the controls and 5 -11 ppm in the ... FAO/PL:1967/M/11/1 WHO/Food Add./68.30 1967 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD THE MONOGRAPHS The content of this ...
During the recovery period of 20 min, valuable returns toward the control levels were observed in the serum levels of 11- ... Among positive stress indices obtained from the experiment on rabbits, the serum levels of 11-hydroxycorticosteroids and free ... On the other hand, addition-subtraction task of 20min provoked significant changes in the serum levels of 11- ... hydroxycorticosteroids and albumin at a lower pace of the task, and in addition to these free fatty acids and protein at a ...
17-hydroxycorticosteroids MeSH D06.472.040.585.478.195 - cortisone MeSH D06.472.040.585.478.225 - cortodoxone MeSH D06.472. ... hydroxycorticosteroids MeSH D06.472.040.585.353 - 11-hydroxycorticosteroids MeSH D06.472.040.585.353.118 - aldosterone MeSH ...
... and 17-hydroxycorticosteroids (OHCS) determined predive and at 10 intervals during the dive. The mood inventory indicated ...
A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as ... "17-Hydroxycorticosteroids" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "17-Hydroxycorticosteroids" by people in Harvard Catalyst ... Below are the most recent publications written about "17-Hydroxycorticosteroids" by people in Profiles. ...
hydroxycorticosteroids.tw,hw,tn,rn.. 11. glucocorticoid$.tw,hw,tn,rn.. 12. triamcinolone.tw,hw,tn,rn. ...
17-Hydroxycorticosteroids/urine , 17-Ketosteroids/urine , Adenoma/metabolism , Adrenal Cortex Neoplasms/metabolism , Adult , ... 11-Hydroxycorticosteroids/blood , Animals , Hypoxia/blood , Body Weight , Lung/anatomy & histology , Male , Organ Size , ...
Hydroxycorticosteroids [D06.472.040.585]. *11-Hydroxycorticosteroids [D06.472.040.585.353]. *Tetrahydrocortisol [D06.472. ...
Looking for online definition of cortisol:corticosterone ratio in the Medical Dictionary? cortisol:corticosterone ratio explanation free. What is cortisol:corticosterone ratio? Meaning of cortisol:corticosterone ratio medical term. What does cortisol:corticosterone ratio mean?
17-hydroxycorticosteroids. *17-hydroxycorticosteroids test. *17-hydroxylase deficiency syndrome. *17-ketoandrosterone. *17- ...
Eleven gastrointestinal phytobezoar in children (less than 15 years old) seen within a period of 8 years (1981-1988) were ... prazole plus vs omeprazole dr 2016-11-29 We examined by immunohistochemistry the effects of monoamine oxidase (MAO) inhibition ... omeprazole drug mechanism 2010-11-21 Intragastric immunization of the recombinant strain conferred protective immunity against ... Fluorimetric determination of free plasma 11-hydroxycorticosteroids in man. Optimization of chick embryotoxicity bioassay for ...
Hydroxycorticosteroids. *Mineralocorticoids. *P-glycoprotein/ABCB1 Inducers. *P-glycoprotein/ABCB1 Substrates. *Pregnanes. * ... Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 3-oxo delta-4-steroids / 11-beta-hydroxysteroids / ... Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the ... Steroid 11-beta-monooxygenase activity. Specific Function. Preferentially catalyzes the conversion of 11-deoxycorticosterone to ...
A method for determination of 11-oxy-17-hydroxy-corticosteroids in urine. Various immunosuppressive drugs have been evaluated ...
1999 The type I and type II 11 beta-hydroxysteroid dehydrogenase enzymes. J. Steroid Biochem. Mol. Biol. 69, 391-401. doi: ... This type of contrast is shown in all the 11β-hydroxy versus 11-keto steroids studied here. Also shown are the geometries taken ... Despite this, the 11-ketone compounds may not achieve appropriate configurations for activity, because their C ring flexibility ... The identification of 11-deoxycorticosterone as a specific mineralocorticoid follows the received view in numerous reviews and ...
Hydroxycorticosteroids: 7*11-Hydroxycorticosteroids: 50*Aldosterone: 8566*3,5-tetrahydroaldosterone sulfate: 180 ... 11/01/2015 - "A total of 42,438 primary THAs were available for analysis of revision outcomes and 22,237 for dislocation. ". ... 11/01/2015 - "The purpose of this study was to evaluate the risk of aseptic revision, septic revision, and dislocations for ... 11/25/2015 - "A total of 465 consecutive primary THAs with a posterolateral approach were performed in patients with primary ...
The elevated endogenous catecholamine release was not accompanied by an increase in plasma 11-hydroxycorticosteroids levels. ...
The drug can also give falsely high values ​​of 11-hydroxycorticosteroids in urine and / or plasma. ...
During days 7-11 he was oriented and didnt have more hallucinations. He could not remember much of what happened in the ... TDC Podcast 11 - Dr. Mark Lysyshyn on Fentanyl Drug Checking, Supervised Consumption Facilities & More. November 2, 2018 ... 50 children with ADHD aged 7.5-11 years. Phenibut group (n=25) received 500-750 mg/d based on bodyweight in 2-3 doses. The ... With prolonged administration it still caused an increase in 11-HCS but the effect size was lower. Along with raising the blood ...
... with increased urinary excretion of 17-hydroxycorticosteroids indicating the normal release of increased amounts of ... doses over a 24-hour period and response was determined by measurement of urinary excretion of 17-hydroxycorticosteroids, which ... The clinical side effects of the tricyclic antidepressant drugs such as imipramine and amitriptyline are usually mild (Table 11 ... 11, 12 It has been shown that 10%-12% of adult and adolescent methadone-maintained patients are chronic carriers of hepatitis B ...
Control containing a comprehensive analyte menu for quantitative assays that monitor the precision of tests for general urine chemistry, biogenic amines, and hormones; contains hCG (Pregnancy) and Microalbumin
"Hydroxycorticosteroids" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Hydroxycorticosteroids" by people in this website by year, and ... Below are the most recent publications written about "Hydroxycorticosteroids" by people in Profiles. ... A group of corticosteroids carrying hydroxy groups, usually in the 11- or 17-positions. They comprise the bulk of the ...
Concentration of catecholamines, II-hydroxycorticosteroids, free and bound hydroxyproline in blood, free and total ... 11. [Changes in the hormone content of the blood during chronic electrical stimulation of the midbrain]. / Izmenenie ... The content of 11-hydroxycorticosteroids, free and bound hydroxyproline in the peripheral blood, as well as the level of free ... Colágeno/metabolismo , Formação Reticular/fisiologia , 11-Hidroxicorticosteroides/sangue , Animais , Aorta/metabolismo , ...
  • Semi-automated high-performance liquid chromatographic method for the simultaneous assay of plasma cortisol and 11-deoxycortisol in the metyrapone test. (harvard.edu)
  • This enzyme may act as a 'gatekeeper' to MR [ 10 ], catalysing the transformation of 11 β -hydroxysteroids, such as the glucocorticoid cortisol, to inactive 11-ketosteroids, such as cortisone. (royalsocietypublishing.org)
  • However, in man, total free cortisol and transcortin-bound cortisol are present in circulating blood at about 1000 times (and free cortisol about 100 times) the concentration of aldosterone, the main mineralocorticoid [ 11 , 12 ]. (royalsocietypublishing.org)
  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically urine) to determine cortisol metabolites, including 17-hydroxycorticosteroids (17-OHCS) and 17-ketosteroid glucoronides (17-KS-G). Other cortisol metabolites include tetrahydro metabolites (e.g. tetrahydrocortisone), hexahydro metabolites (e.g., alpha and beta cortols, cortolones), and 11-oxygenated ketosteroids (e.g., 11-ketoandrosterone). (ophthalmologymanagement.com)
  • The pharmacological effect of Metopirone is to reduce cortisol and corticosterone production by inhibiting the 11-β-hydroxylation reaction in the adrenal cortex. (rxdrugsinfo.com)
  • With continued blockade of the enzymatic steps leading to production of cortisol and corticosterone, there is a marked increase in adrenocortical secretion of their immediate precursors, 11-desoxycortisol and desoxycorticosterone, which are weak suppressors of ACTH release, and a corresponding elevation of these steroids in the plasma and of their metabolites in the urine. (rxdrugsinfo.com)
  • For a short Dexamethasone suppression test, 1mg Dexamethasone is given at 11 p.m. and plasma cortisol measured the next morning. (medicinep.com)
  • Mean plasma concentrations of deoxycorticosterone and cortisol were unchanged during aminoglutethimide treatment whereas those of 18-hydroxydeoxycorticosterone, progesterone, 17α-hydroxyprogesterone, and 11-deoxycortisol were increased as compared to pretreatment values. (utmb.edu)
  • How is 11-deoxy-cortisol converted to cortisol? (brainscape.com)
  • 11-Deoxycorticosterone, or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. (definitions.net)
  • Excretion rates of 16β-hydroxydehydroepiandrosterone, 16-oxo-androstenediol, 17-hydroxycorticosteroids and 17-ketosteroids, and the secretion rate of 16β-hydroxydehydroepiandrosterone were not significantly altered by aminoglutethimide treatment whereas the excretion rate of aldosterone was reduced from 3.62±0.5 (mean±SE) in the control period to 0.9±0.2 μg/24 h after 4 days and to 1.1±0.3 μg/24 h at the termination of aminoglutethimide treatment. (utmb.edu)
  • How is 11-deoxy-corticosterone transformed to aldosterone? (brainscape.com)
  • Pretreatment of rats with gamma-oryzanol 100 mg/kg, s.c., for 5 days tended to decrease serum gastrin levels and gastric secretion, and to increase serum 11-OHCS. (nih.gov)
  • Among positive stress indices obtained from the experiment on rabbits, the serum levels of 11-hydroxycorticosteroids and free fatty acids were suggested to be especially useful for the study of emotional stress responses. (go.jp)
  • On the other hand, 'addition-subtraction task' of 20min provoked significant changes in the serum levels of 11-hydroxycorticosteroids and albumin at a lower pace of the task, and in addition to these free fatty acids and protein at a higher pace of the task comparing with the control levels. (go.jp)
  • As its names indicate, 11-deoxycorticosterone can be understood as the 21-hydroxy- variant of progesterone or as the 11-deoxy- variant of corticosterone. (definitions.net)
  • Accumulation of these substrates, pregnenolone and progesterone will enhance the 21-hydroxylation and 11 [beta]-hydroxylation steps in the mineralocorticoid pathway resulting in an overproduction of 11-deoxycorticosterone and corticosterone. (thefreedictionary.com)
  • As measured by HPLC, corticosterone and 11-deoxycorticosterone secretion to the medium increased linearly for at least 24 hr. (thefreedictionary.com)
  • A group of corticosteroids bearing a hydroxy group at the 11-position. (harvard.edu)
  • Deficiency of 21-hydroxylase prevents the conversion of 17-hydroxyprogesterone to 11-deoxycorticosterone , leading to excessive production of androgens, which ultimately affects several stages of growth and development (4). (thefreedictionary.com)
  • Results: Of 433 patients (270 girls, 163 boys), 347 (80.1%) (226 girls, 121 boys) were diagnosed as having 21 hydroxylase deficiency (21OHD) 260 (75%) were salt waster, 76 (22%) had simple virilizing and 11 girls (3%) had late onset type. (ac.ir)
  • Sixty-three (14.5%) had 11 hydroxylase deficiencie, 11 (2.5%) had 3βhydroxysteroid dehydrogenase deficiency, 3 (0.7%) lipoid adrenal hyperplasia, 5 girls (1.2%) 17-hydroxylase deficiency and 4 patients (0.9%) had hyperreninemic hypoaldosteronism. (ac.ir)
  • A self-report mood inventory and a pain complaint survey were administered daily to each diver, with urinary excretion levels of epinephrine, norepinephrine, 11- and 17-hydroxycorticosteroids (OHCS) determined predive and at 10 intervals during the dive. (ovid.com)
  • The urinary excretions of 17-ketosteroids and 17-hydroxycorticosteroids were also increased. (bvsalud.org)
  • These metabolites are readily determined by measuring urinary 17-hydroxycorticosteroids (17-OHCS) or 17-ketogenic steroids (17-KGS). (rxdrugsinfo.com)
  • Material and method: Diagnosis was based on measurement of 24-hour urine 17 ketosteroids and pregnanetriol, 17 hydroxycorticosteroids (Porter Silber method). (ac.ir)
  • Other tests to dis- evaluation, to rule out CS, either have no evidence for tinguish CD from PCS have been described but not fully hypercortisoluria, or minimal elevation of urine free cor- tisol (UFC) or 17-hydroxycorticosteroids (17OHCS). (pharmapdf.com)
  • 17-Hydroxycorticosteroids (17-ketogenic steroids) test system. (fda.gov)
  • Hydroxycorticosteroids (OHCSs) are corticosteroids that have an additional hydroxy (-OH) group. (wikipedia.org)
  • A group of corticosteroids carrying hydroxy groups, usually in the 11- or 17-positions. (sickkids.ca)
  • One unexpected example is 11-deoxycorticosterone, which the methods predict (and our activity studies confirm) is not only a specific mineralocorticoid, but also has significant glucocorticoid activity. (royalsocietypublishing.org)
  • An apparent solution to this problem comes from the discovery that some mineralocorticoid targets, notably the kidney, abundantly contain the enzyme 11 β -hydroxysteroid dehydrogenase type II (11 β -HSD2) [ 9 ]. (royalsocietypublishing.org)
  • All of our 11 patients presented with hyperfunction of the adrenal cortex. (ac.ir)
  • The hydroxycorticosteroids are mostly the mineralocorticoids and are mainly produced in the zona glomerulosa layer (the outermost layer of the adrenal gland) of the adrenal cortex. (citizendium.org)
  • Deficiency in the CYP21 gene prevents the conversion of 17-hydroxyprogesterone to 11-deoxycorticosterone , leading to an excessive production of androgen, which in turn affects several stages of growth and development (1). (thefreedictionary.com)
  • United States Patent 0 Patented Sept. 11, 1962 2 1 amples are adrenal, gonadal and thyroid hormones, vari 3,053,737 ous phenols and alcohols bearing a free hydroxyl group, various amines such as aniline, p-phenetidine, and p-tol uidine. (docme.ru)
  • 11-Hydroxycorticosteroids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • 17-Hydroxycorticosteroids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • What does 11-deoxycorticosterone mean? (definitions.net)
  • Here are all the possible meanings and translations of the word 11-deoxycorticosterone . (definitions.net)
  • Are we missing a good definition for 11-deoxycorticosterone ? (definitions.net)
  • What rhymes with 11-deoxycorticosterone ? (definitions.net)
  • We have tentatively identified 11-deoxycorticosterone , androstadienedione, and androstenedione in the effluent. (thefreedictionary.com)
  • Twenty-one of 85 patients had no virilization, 11 had grade 5 of Prader staging. (ac.ir)
  • Given that 11 β -HSD2 may not always be exactly co-located with MR [ 13 ], clearance of active glucocorticoid by 11 β -HSD2 is unlikely to be complete [ 14 ]. (royalsocietypublishing.org)
  • Even in tissues with plentiful 11 β -HSD2, MR may be chronically occupied by glucocorticoid, though seemingly only activated under special conditions [ 12 ]. (royalsocietypublishing.org)
  • The CRH stimulation test, valuable in differentiating the syndrome Patients with PCS have decreased ability to secrete of ectopic ACTH from Cushing's disease (CD) (6, 17), is ACTH in response to CRH because of the glucocorticoid also of limited use in the differential diagnosis between negative feedback exerted by chronic hypercortisolism PCS and CD because there is considerable overlap with the (11). (pharmapdf.com)
  • The elevated endogenous catecholamine release was not accompanied by an increase in plasma 11-hydroxycorticosteroids levels. (statescale.cf)
  • Therefore, future work, with appropriate sample size, on adrenal mechanisms of microfilarial periodicity should preferably be based on more direct indices such as plasma 17-hydroxycorticosteroids. (ajtmh.org)
  • During a period of IS years from 1975 to 1989, eleven children with adrenocortical tumors were managed with relatively favorable results in our center. (ac.ir)
  • Trilostane [ (4α, 5α, 17β) -3,17-dihydroxy-4,5-epoxyhydrost-2-en-2-carbonitrile ] is an inhibitor adrenocortical steroidogenesis. (anabolicdietblog.com)
  • This graph shows the total number of publications written about "11-Hydroxycorticosteroids" by people in Harvard Catalyst Profiles by year, and whether "11-Hydroxycorticosteroids" was a major or minor topic of these publication. (harvard.edu)
  • In nine out of 11 patients the tumor was on the right side. (ac.ir)
  • There are two main positions where the hydroxy group may be added: at carbon atom 11, and at carbon atom 17. (wikipedia.org)
  • 50 children with ADHD aged 7.5-11 years. (thedrugclassroom.com)
  • The age distribution ranged from 16 months to 14 years of age, and the mean was 5 years & 11 months (median 4 years & 2 months). (bvsalud.org)
  • At a mean follow-up of five years, 10 out of 11 children were alive and had no evidence of tumor recurrence. (ac.ir)
  • 17-hydroxycorticosteroids is also high, as it always is for me. (blogspot.com)
  • Radioimmunoassays were developed for 11-deoxycortisol and for 3 alpha,17,21-P-5 beta and were applied to fractions of mature male and female plaice plasmas and plaice ovarian incubates that had been separated on thin-layer chromatography. (ualg.pt)
  • compound s (11-deoxycortisol) test system. (fda.gov)
  • Enrollment in the ZDV/ddI arm stopped after 11 months on the basis of results of PACTG Protocol 152, but blinded follow-up continued. (faintpower.tk)