1-Sarcosine-8-Isoleucine Angiotensin II: An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR.Sarcosine: An amino acid intermediate in the metabolism of choline.Sarcosine Oxidase: A FLAVOPROTEIN, this enzyme catalyzes the oxidation of SARCOSINE to GLYCINE; FORMALDEHYDE; and HYDROGEN PEROXIDE (H2O2).Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Isoleucine: An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.Sarcosine Dehydrogenase: A LIVER mitochondrial matrix flavoenzyme that catalyzes the oxidation of SARCOSINE to GLYCINE and FORMALDEHYDE. Mutation in the enzyme causes sarcosinemia, a rare autosomal metabolic defect characterized by elevated levels of SARCOSINE in BLOOD and URINE.Receptor, Angiotensin, Type 1: An angiotensin receptor subtype that is expressed at high levels in a variety of adult tissues including the CARDIOVASCULAR SYSTEM, the KIDNEY, the ENDOCRINE SYSTEM and the NERVOUS SYSTEM. Activation of the type 1 angiotensin receptor causes VASOCONSTRICTION and sodium retention.Receptors, Angiotensin: Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.Receptor, Angiotensin, Type 2: An angiotensin receptor subtype that is expressed at high levels in fetal tissues. Many effects of the angiotensin type 2 receptor such as VASODILATION and sodium loss are the opposite of that of the ANGIOTENSIN TYPE 1 RECEPTOR.Angiotensin Receptor Antagonists: Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR.Angiotensin I: A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.TetrazolesAngiotensin II Type 2 Receptor Blockers: Agents that antagonize the ANGIOTENSIN II TYPE 2 RECEPTOR.Angiotensin III: A heptapeptide formed from ANGIOTENSIN II after the removal of an amino acid at the N-terminal by AMINOPEPTIDASE A. Angiotensin III has the same efficacy as ANGIOTENSIN II in promoting ALDOSTERONE secretion and modifying renal blood flow, but less vasopressor activity (about 40%).Dimethylglycine Dehydrogenase: A FLAVOPROTEIN enzyme that catalyzes the oxidative demethylation of dimethylglycine to SARCOSINE and FORMALDEHYDE.Glycine Plasma Membrane Transport Proteins: A family of sodium chloride-dependent neurotransmitter symporters that transport the amino acid GLYCINE. They differ from GLYCINE RECEPTORS, which signal cellular responses to GLYCINE. They are located primarily on the PLASMA MEMBRANE of NEURONS; GLIAL CELLS; EPITHELIAL CELLS; and RED BLOOD CELLS where they remove inhibitory neurotransmitter glycine from the EXTRACELLULAR SPACE.Glycine N-Methyltransferase: An enzyme that catalyzes the METHYLATION of GLYCINE using S-ADENOSYLMETHIONINE to form SARCOSINE with the concomitant production of S-ADENOSYLHOMOCYSTEINE.Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Biphenyl CompoundsSaralasin: An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.Peptidyl-Dipeptidase A: A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Oxidoreductases, N-DemethylatingRenin: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.Benzimidazoles: Compounds with a BENZENE fused to IMIDAZOLES.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Angiotensins: Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANGIOTENSIN SYSTEM. These include angiotensins derived naturally from precursor ANGIOTENSINOGEN, and those synthesized.Glycine: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
(1/50) Regulation of angiotensin II receptors and PKC isoforms by glucose in rat mesangial cells.

It has been shown that glomerular angiotensin II (ANG II) receptors are downregulated and protein kinase C (PKC) is activated under diabetic conditions. We, therefore, investigated ANG II receptor and PKC isoform regulation in glomerular mesangial cells (MCs) under normal and elevated glucose concentrations. MCs were isolated from collagenase-treated rat glomeruli and cultured in medium containing normal or high glucose concentrations (5.5 and 25.0 mM, respectively). Competitive binding experiments were performed using the ANG II antagonists losartan and PD-123319, and PKC analysis was conducted by Western blotting. Competitive binding studies showed that the AT1 receptor was the only ANG II receptor detected on MCs grown to either subconfluence or confluence under either glucose concentration. AT1 receptor density was significantly downregulated in cells grown to confluence in high-glucose medium. Furthermore, elevated glucose concentration enhanced the presence of all MC PKC isoforms. In addition, PKCbeta, PKCgamma and PKCepsilon were translocated only in cells cultured in elevated glucose concentrations following 1-min stimulation by ANG II, whereas PKCalpha, PKCtheta, and PKClambda were translocated by ANG II only in cells grown in normal glucose. Moreover, no changes in the translocation of PKCdelta, PKCiota, PKCzeta, and PKCmu were detected in response to ANG II stimulation under euglycemic conditions. We conclude that MCs grown in high glucose concentration show altered ANG II receptor regulation as well as PKC isoform translocation compared with cells grown in normal glucose concentration.  (+info)

(2/50) Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.

The carboxyl-terminal cytoplasmic domain of the angiotensin II type 1 (AT1) receptor has recently been shown to interact with several classes of cytoplasmic proteins that regulate different aspects of AT1 receptor physiology. Employing yeast two-hybrid screening of a mouse kidney cDNA library with the carboxyl-terminal cytoplasmic domain of the murine AT1a receptor as a bait, we have isolated a novel protein with a predicted molecular mass of 18 kDa, which we have named ATRAP (for AT1 receptor-associated protein). ATRAP interacts specifically with the carboxyl-terminal domain of the AT1a receptor but not with those of angiotensin II type 2 (AT2), m3 muscarinic acetylcholine, bradykinin B2, endothelin B, and beta2-adrenergic receptors. The mRNA of ATRAP was abundantly expressed in kidney, heart, and testis but was poorly expressed in lung, liver, spleen, and brain. The ATRAP-AT1a receptor association was confirmed by affinity chromatography, by specific co-immunoprecipitation of the two proteins, and by fluorescence microscopy, showing co-localization of these proteins in intact cells. Overexpression of ATRAP in COS-7 cells caused a marked inhibition of AT1a receptor-mediated activation of phospholipase C without affecting m3 receptor-mediated activation. In conclusion, we have isolated a novel protein that interacts specifically with the carboxyl-terminal cytoplasmic domain of the AT1a receptor and affects AT1a receptor signaling.  (+info)

(3/50) Dynamic Ca2+ signalling in rat arterial smooth muscle cells under the control of local renin-angiotensin system.

1. We visualized the changes in intracellular Ca2+ concentration ([Ca2+]i), using fluo-3 as an indicator, in individual smooth muscle cells within intact rat tail artery preparations. 2. On average in about 45 % of the vascular smooth muscle cells we found spontaneous Ca2+ waves and oscillations ( approximately 0.13 Hz), which we refer to here as Ca2+ ripples because the peak amplitude of [Ca2+]i was about one-seventh of that of Ca2+ oscillations evoked by noradrenaline. 3. We also found another pattern of spontaneous Ca2+ transients often in groups of two to three cells. They were rarely observed and are referred to as Ca2+ flashes because their peak amplitude was nearly twice as large as that in noradrenaline-evoked responses. 4. Sympathetic nerve activity was not considered responsible for the Ca2+ ripples, and they were abolished by inhibitors of either the Ca2+ pump in the sarcoplasmic reticulum (cyclopiazonic acid) or phospholipase C (U-73122). 5. Both angiotensin antagonists ([Sar1,Ile8]-angiotensin II and losartan) and an angiotensin converting enzyme inhibitor (captopril) inhibited the Ca2+ ripples. 6. The extracellular Ca2+-dependent tension borne by unstimulated arterial rings was reduced by the angiotensin antagonist by approximately 50 %. 7. These results indicate that the Ca2+ ripples are generated via inositol 1,4, 5-trisphosphate-induced Ca2+ release from the intracellular Ca2+ stores in response to locally produced angiotensin II, which contributes to the maintenance of vascular tone.  (+info)

(4/50) Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.

Angiotensin II (AII) is a major determinant of arterial pressure and volume homeostasis, mainly because of its vascular action via the AII type 1 receptor (AT1R). AII has also been implicated in the development of cardiac hypertrophy because angiotensin I-converting enzyme inhibitors and AT1R antagonists prevent or regress ventricular hypertrophy in animal models and in human. However, because these treatments impede the action of AII at cardiac as well as vascular levels, and reduce blood pressure, it has been difficult to determine whether AII action on the heart is direct or a consequence of pressure-overload. To determine whether AII can induce cardiac hypertrophy directly via myocardial AT1R in the absence of vascular changes, transgenic mice overexpressing the human AT1R under the control of the mouse alpha-myosin heavy chain promoter were generated. Cardiomyocyte-specific overexpression of AT1R induced, in basal conditions, morphologic changes of myocytes and nonmyocytes that mimic those observed during the development of cardiac hypertrophy in human and in other mammals. These mice displayed significant cardiac hypertrophy and remodeling with increased expression of ventricular atrial natriuretic factor and interstitial collagen deposition and died prematurely of heart failure. Neither the systolic blood pressure nor the heart rate were changed. The data demonstrate a direct myocardial role for AII in the development of cardiac hypertrophy and failure and provide a useful model to elucidate the mechanisms of action of AII in the pathogenesis of cardiac diseases.  (+info)

(5/50) Molecular cloning of a ferret angiotensin II AT(1) receptor reveals the importance of position 163 for Losartan binding.

A complementary DNA for the angiotensin II (AngII) type 1 (AT(1)) receptor from Mustela putorius furo (ferret) was isolated from a ferret atria cDNA library. The cDNA encodes a protein (fAT(1)) of 359 amino acids having high homologies (93-99%) to other mammalian AT(1) receptor counterparts. When fAT(1) was expressed in COS-7 cells and photoaffinity labeled with the photoactive analogue (125)I- inverted question markSar(1), Bpa(8)AngII, a protein of 100 kDa was detected by autoradiography. The formation of this complex was specific since it was abolished in the presence of the AT(1) non-peptidic antagonist L-158,809. Functional analysis indicated that the fAT(1) receptor efficiently coupled to phospholipase C as demonstrated by an increase in inositol phosphate production following stimulation with AngII. Binding studies revealed that the fAT(1) receptor had a high affinity for the peptide antagonist inverted question markSar(1), Ile(8)AngII (K(d) of 5. 8+/-1.4 nM) but a low affinity for the AT(1) selective non-peptidic antagonist DuP 753 (K(d) of 91+/-15.6 nM). Interestingly, when we substituted Thr(163) with an Ala residue, which occupies this position in many mammalian AT(1) receptors, we restored the high affinity of this receptor for Dup 753 (11.7+/-5.13 nM). These results suggest that position 163 of the AT(1) receptor does not contribute to the overall binding of peptidic ligands but that certain non-peptidic antagonists such as Dup 753 are clearly dependent on this position for efficient binding.  (+info)

(6/50) The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities.

BACKGROUND: Endogenous intratubular angiotensin II (Ang II) supports an autocrine tonic stimulation of NaCl absorption in the proximal tubule, and its production may be regulated independently of circulating Ang II. In addition, endogenous Ang II activity may be regulated at the brush border membrane (BBM), by the rate of aminopeptidase A and N (APA and APN) activities and the rate of Ca2+-independent phospholipase A2 (PLA2-dependent endocytosis and recycling of the complex Ang II subtype 1 (AT1) receptor (AT1-R). The aim of the present study was to look for subcellular localization of AT1-R, and APA and APN activities in the medullary thick ascending limb of Henle (mTAL), as well as search for an asymmetric coupling of AT1-R to signal transduction pathways. METHODS: Preparations of isolated basolateral membrane (BLMV) and luminal (LMV) membrane vesicles from rat mTAL were used to localize first, AT1-R by 125I-[Sar1, Ile8] Ang II binding studies and immunoblot experiments with a specific AT1-R antibody, and second, APA and APN activities. Microfluorometric monitoring of cytosolic Ca2+ with a Fura-2 probe was performed in mTAL microperfused in vitro, after apical or basolateral application of Ang II. RESULTS: AT1-R were present in both LMV and BLMV, with a similar Kd (nmol/L range) and Bmax. Accordingly, BLMV and LMV preparations similarly stained specific AT1-R antibody. APA and APN activities were selectively localized in LMV, although to a lesser extent than those measured in BBM. In the in vitro microperfused mTAL, basolateral but not apical Ang II induced a transient increase in cytosolic [Ca2+]. CONCLUSIONS: Besides the presence of basolateral AT1-R in mTAL coupled to the classical Ca2+-dependent transduction pathways, AT1-R are present in LMV, not coupled with Ca2+ signaling, and co-localized with APA and APN activities. Thus, apical APA and APN may play an important role in modulating endogenous Ang II activity on NaCl reabsorption in mTAL.  (+info)

(7/50) AT1 receptors in the RVLM mediate pressor responses to emotional stress in rabbits.

In this study, we examined the role of angiotensin type 1 (AT1) receptors in the rostral ventrolateral medulla (RVLM) in mediating the pressor action of emotional stress in conscious rabbits. Rabbits were chronically instrumented with guide cannulas for bilateral microinjections into the RVLM and an electrode for measuring renal sympathetic nerve activity (RSNA). Airjet stress evoked increases in arterial pressure, heart rate, and RSNA, which reached a maximum (+9+/-1 mm Hg, +20+/-5 beats/min, and +93+/-17%, respectively) in the first 2 minutes of stress exposure. Then RSNA rapidly returned to prestress values, while arterial pressure and heart rate remained close to the maximal level until the conclusion of the 7-minute airjet exposure. Microinjections of the nonselective angiotensin receptor antagonist sarile (0.5 nmol, n=8) or AT1 receptor antagonists losartan (2 nmol, n=6) or candesartan (0.2 nmol, n=6) into the RVLM did not alter resting cardiovascular parameters. By contrast, the antagonists attenuated the sustained phase (4 to 7 minutes) of the pressor stress response by 55% to 89%. However, only sarile decreased the onset of this response. The antagonists affected neither the stress-induced tachycardia nor the pressor response to glutamate microinjections. Microinfusion of angiotensin II (4 pmol/min, n=8) into the RVLM did not change the pressor response to airjet stress but attenuated tachycardic response by 47%. Microinjections of vehicle did not alter the cardiovascular stress response. Sarile, losartan, and angiotensin II did not affect the sympathoexcitatory response to baroreceptor unloading. These results suggest that AT1 receptors in the RVLM are important in mediating the pressor effects of emotional stress in conscious rabbits.  (+info)

(8/50) Autocrine angiotensin system regulation of bovine aortic endothelial cell migration and plasminogen activator involves modulation of proto-oncogene pp60c-src expression.

Rapid endothelial cell migration and inhibition of thrombosis are critical for the resolution of denudation injuries to the vessel wall. Inhibition of the endothelial cell autocrine angiotensin system, with either the angiotensin-converting enzyme inhibitor lisinopril or the angiotensin II receptor antagonist sar1, ile8-angiotensin II, leads to increased endothelial cell migration and urokinase-like plasminogen activator (u-PA) activity (Bell, L., and J. A. Madri. 1990. Am. J. Pathol. 137:7-12). Inhibition of the autocrine angiotensin system with the converting-enzyme inhibitor or the receptor antagonist also leads to increased expression of the proto-oncogene c-src: pp60c-src mRNA increased 7-11-fold, c-src protein 3-fold, and c-src kinase activity 2-3-fold. Endothelial cell expression of c-src was constitutively elevated after stable infection with a retroviral vector containing the c-src coding sequence. Constitutively increased c-src kinase activity reconstituted the increases in migration and u-PA observed with angiotensin system interruption. Antisera to bovine u-PA blocked the increase in migration associated with increased c-src expression. These data suggest that increases in endothelial cell migration and plasminogen activator after angiotensin system inhibition are at least partially pp60c-src mediated. Elevated c-src expression with angiotensin system inhibition may act to enhance intimal wound closure and to reduce luminal thrombogenicity in vivo.  (+info)

*  List of MeSH codes (D23)
... angiotensin i MeSH D23.469.050.050.050 --- angiotensin ii MeSH D23.469.050.050.050.050 --- angiotensin amide MeSH D23.469. ... type ii MeSH D23.050.301.264.035.915 --- p-selectin MeSH D23.050.301.264.035.920 --- vascular cell adhesion molecule-1 MeSH ... type ii MeSH D23.101.100.110.925 --- e-selectin MeSH D23.101.100.110.930 --- p-selectin MeSH D23.101.100.110.970 --- vascular ... histocompatibility antigens class ii MeSH D23.050.301.500.410.400 --- hla-d antigens MeSH D23.050.301.500.410.400.420 --- HLA- ...
*  List of MeSH codes (D12.644)
... angiotensin i MeSH D12.644.400.070.078 --- angiotensin ii MeSH D12.644.400.070.080 --- angiotensin iii MeSH D12.644.400.085 ... angiotensin i MeSH D12.644.456.073.041 --- angiotensin ii MeSH D12.644.456.073.041.050 --- angiotensin amide MeSH D12.644. ... casein kinase ii MeSH D12.644.360.200 --- cyclic nucleotide-regulated protein kinases MeSH D12.644.360.200.125 --- cyclic amp- ... interferon type ii MeSH D12.644.276.174.440.893.510 --- interferon-gamma, recombinant MeSH D12.644.276.174.480 --- lymphokines ...
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information  Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
An ANGIOTENSIN II analog which acts as a highly specific inhibitor of ANGIOTENSIN TYPE 1 RECEPTOR. ... 1-Sarcosine-8-isoleucine angiotensin II View Synonyms. Description:. ...
more infohttps://druginfo.nlm.nih.gov/drugportal/rn/9088-01-1
125I[Sar1Ile8] Angiotensin II has a different affinity for AT1 and AT2 receptor subtypes in ovine tissues  125I[Sar1Ile8] Angiotensin II has a different affinity for AT1 and AT2 receptor subtypes in ovine tissues
Iodinated angiotensin II (Ang II) and its analogues are often assumed to have equal affinities for AT(1) and AT(2) receptor ... 125I[Sar1Ile8] Angiotensin II has a different affinity for AT1 and AT2 receptor subtypes in ovine tissues Academic Article * ... 1)Ile(8)] Ang II for Ang II receptors was different (P. ... 1-Sarcosine-8-Isoleucine Angiotensin II (MeSH) * Adrenal Glands ...
more infohttps://scholars.latrobe.edu.au/display/publication364214
List of MeSH codes (D23) - Wikipedia  List of MeSH codes (D23) - Wikipedia
... angiotensin i MeSH D23.469.050.050.050 --- angiotensin ii MeSH D23.469.050.050.050.050 --- angiotensin amide MeSH D23.469. ... type ii MeSH D23.050.301.264.035.915 --- p-selectin MeSH D23.050.301.264.035.920 --- vascular cell adhesion molecule-1 MeSH ... type ii MeSH D23.101.100.110.925 --- e-selectin MeSH D23.101.100.110.930 --- p-selectin MeSH D23.101.100.110.970 --- vascular ... histocompatibility antigens class ii MeSH D23.050.301.500.410.400 --- hla-d antigens MeSH D23.050.301.500.410.400.420 --- HLA- ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
List of MeSH codes (D12.644) - Wikipedia  List of MeSH codes (D12.644) - Wikipedia
... angiotensin i MeSH D12.644.400.070.078 --- angiotensin ii MeSH D12.644.400.070.080 --- angiotensin iii MeSH D12.644.400.085 ... angiotensin i MeSH D12.644.456.073.041 --- angiotensin ii MeSH D12.644.456.073.041.050 --- angiotensin amide MeSH D12.644. ... casein kinase ii MeSH D12.644.360.200 --- cyclic nucleotide-regulated protein kinases MeSH D12.644.360.200.125 --- cyclic amp- ... interferon type ii MeSH D12.644.276.174.440.893.510 --- interferon-gamma, recombinant MeSH D12.644.276.174.480 --- lymphokines ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
Pressor responses to norepinephrine in rabbits with 3-day and 30-day renal artery stenosis. The role of angiotensin II. |...  Pressor responses to norepinephrine in rabbits with 3-day and 30-day renal artery stenosis. The role of angiotensin II. |...
Infusions of angiotensin II (A II) in either subpressor or pressor amounts potentiated the pressor responses to NE in normal ... angiotensin II, did not alter the pressor responses of normal rabbits to NE, but this A II analogue completely abolished the ... The role of angiotensin II.. S Ichikawa, J A Johnson, W L Fowler, C G Payne, K Kurz, W F Keitzer ... Also, these results provide evidence that A II plays an important role in the increased pressor responses to NE in hypertensive ...
more infohttp://circres.ahajournals.org/content/43/3/437
Browse by Journal Title - MDC Repository  Browse by Journal Title - MDC Repository
Relaxin does not improve angiotensin II-induced target-organ damage.. Haase, N. and Rugor, J. and Przybyl, L. and Qadri, F. and ... Isoleucine(8) angiotensin II in neurolysin knockout mouse brains.. Speth, R.C. and Carrera, E.J. and Bretón, C. and Linares, A. ... I-Sarcosine(1), ... A two-way communication between microglial cells and angiogenic ... Relaxin treatment in an Ang-II-based transgenic reeclamptic-rat model.. Haase, N. and Golic, M. and Herse, F. and Rugor, J. and ...
more infohttps://edoc.mdc-berlin.de/view/journals/PLoS_ONE.html
Patent US7729761 - Method and apparatus for controlled gene or protein delivery - Google Patents  Patent US7729761 - Method and apparatus for controlled gene or protein delivery - Google Patents
wherein sensing the renal function comprises sensing at least one of a renal output, a filtration rate, and an angiotensin II ... For example, it is reasonable to expect that replacement of a leucine with an isoleucine or valine, an aspartate with a ... sarcosine, ε-N,N,N-trimethyllysine, ε-N-acetyllysine, N-acetylserine, N-formylmethionine, 3-methylhistidine, 5-hydroxylysine, ω ... Event detector 213 detects the abnormal condition when the sensed angiotensin II levels exceed a predetermined threshold level. ...
more infohttp://www.google.com/patents/US7729761?dq=artistshare
Application # 2017/0189470. PEPTIDE AND PEPTIDOMIMETIC INHIBITORS - Patents.com  Application # 2017/0189470. PEPTIDE AND PEPTIDOMIMETIC INHIBITORS - Patents.com
... sarcosine, Ser, N-methyl-serine, Pro, Thr, N-methyl-threonine, Val, N-methyl-valine, Ile, N-methyl-isoleucine, Phe, N-methyl- ... exploited to crosslink two sites of the polypeptide to produce a cyclic molecule. In one method, the thiol groups of two ... 0007] Bradykinin is normally degraded by angiotensin converting enzyme (ACE), and patients treated with ACE inhibitors for ... sarcosine, Ser, N-methyl-serine, Pro, Thr, N-methyl-threonine, Val, N-methyl-valine, Ile, N-methyl-isoleucine, Phe, N-methyl- ...
more infohttp://patents.com/us-20170189470.html
Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands  Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands
G. F. Gonzales, V. Vasquez, D. Rodriguez et al., "Effect of two different extracts of red maca in male rats with testosterone- ... and sarcosine (0.70 mg). Minerals reportedly found in maca were iron (16.6 mg/100 g dry matter), calcium (150 mg/100 g dry ... isoleucine (47.4 mg), glutamic acid (156.5 mg), serine (50.4 mg), and aspartic acid (91.7 mg). Other amino acids present but in ... maca significantly inhibited the hypertension relevant angiotensin I-converting enzyme (ACE) in vitro [69]. ...
more infohttps://www.hindawi.com/journals/ecam/2012/193496/
The gut microbiota modulates host amino acid and glutathione metabolism in mice | Molecular Systems Biology  The gut microbiota modulates host amino acid and glutathione metabolism in mice | Molecular Systems Biology
We found that isoleucine, proline, and valine are only consumed by the E. rectale, and glycine, serine, alanine, cystine, ... Taken together, we found that the levels of the glycine and serine as well as the N‐acetylated form of these two AAs that may ... We found that the expression of Sardh that converts sarcosine to the glycine in the mitochondria is significantly lower (Q‐ ... and Khk involved in fructose metabolism as well as Ace2 transcription factor involved in the conversion of angiotensin were ...
more infohttp://msb.embopress.org/content/11/10/834.export
The gut microbiota modulates host amino acid and glutathione metabolism in mice | Molecular Systems Biology  The gut microbiota modulates host amino acid and glutathione metabolism in mice | Molecular Systems Biology
We found that isoleucine, proline, and valine are only consumed by the E. rectale, and glycine, serine, alanine, cystine, ... Taken together, we found that the levels of the glycine and serine as well as the N‐acetylated form of these two AAs that may ... We found that the expression of Sardh that converts sarcosine to the glycine in the mitochondria is significantly lower (Q‐ ... and Khk involved in fructose metabolism as well as Ace2 transcription factor involved in the conversion of angiotensin were ...
more infohttp://msb.embopress.org/content/11/10/834
US5449662A - Atrial natriuretic peptide clearance inhibitors which resist degradation 
        - Google Patents  US5449662A - Atrial natriuretic peptide clearance inhibitors which resist degradation - Google Patents
One or two of the residues in the peptides of the invention may be replaced by the corresponding D isomer, in addition to, or ... Neutral/nonpolar/large/nonaromatic: Valine, Isoleucine, Leucine, Methionine;. Neutral/nonpolar/large/aromatic: Phenylalanine, ... sarcosine (Sar), ornithine (Orn), citrulline (Cit), t-butylalanine (t-BuA), t-butylglycine (t-BuG), N-methylisoleucine (N-MeIle ... or with an angiotensin converting enzyme inhibitor). In this disclosure, the inhibitors of the neutral metalloendopeptidase ...
more infohttps://patents.google.com/patent/US5449662A/en
POLISHING LIQUID FOR METAL AND POLISHING METHOD USING THE SAME - Patent application  POLISHING LIQUID FOR METAL AND POLISHING METHOD USING THE SAME - Patent application
... angiotensin I, angiotensin II and antipain. [0100]Among the organic acids and the amino acids, the following aminocarboxylic ... L-isoleucine, L-alloisoleucine, L-phenylalanine, L-proline, sarcosine, L-ornithine, L-lysine, taurine, L-serine, L-threonine, L ... II) in combination with the benzotriazole derivative represented by Formula (I): X-L-X (II) [0159]wherein, in Formula (II), X1 ... II) in combination with the benzotriazole derivative represented by Formula (I):X-L-X (II)wherein, in Formula (II), X1 and X2 ...
more infohttp://www.patentsencyclopedia.com/app/20090239380
COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETES - Patent application  COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETES - Patent application
... which is derived from natural Angiotensin II (Ang-(1-8)) (Asp1-Arg2-Nle3-Cyc4-Ile5-His6-Cyc7-Ph- e8, SEQ ID NO:9); [0129] a 4,7 ... The nonpolar (hydrophobic) amino acids include leucine, isoleucine, alanine, phenylalanine, valine, proline, tryptophan, and ... sarcosine) or Suc (succinic acid). In certain such embodiments, Xaa1 is a negatively-charged amino acid, such as Asp or Glu, ... Examples of Cyc4 (taken with Cyc7) are shown in Formulas (I), (II) and (III). Typically, the R groups in Formulae (I), (II) and ...
more infohttp://www.patentsencyclopedia.com/app/20140088002
Patente US20070155674 - Substituted azetidinone compounds, processes for preparing the same ... - Google Patentes  Patente US20070155674 - Substituted azetidinone compounds, processes for preparing the same ... - Google Patentes
... angiotensin II receptor antagonists (candesartan, irbesartan, losartan potassium, candesartan cilexetil, telmisartan); anti- ... sarcosine, N-methylisoleucine, 6-N-methyllysine, N-methylvaline, norvaline, norleucine, ornithine and N-methylglycine. ... isoleucine, leucine, lysine, methionine, phenylanine, proline, serine, threonine, tryptophane, tyrosine, valine, 2-aminoadipic ... for individuals with two or more risk factors is ,130 mg/dL (3.37 mmol/L) and for individuals with fewer than two risk factors ...
more infohttp://www.google.es/patents/US20070155674
Oxytocin - Wikipedia  Oxytocin - Wikipedia
At least two uncontrolled studies have found increases in plasma oxytocin at orgasm - in both men and women.[103][104] Plasma ... Oxytocin is a peptide of nine amino acids (a nonapeptide) in the sequence cysteine-tyrosine-isoleucine-glutamine-asparagine- ... The two genes are believed to result from a gene duplication event; the ancestral gene is estimated to be about 500 million ... The two genes are usually located close to each other (less than 15,000 bases apart) on the same chromosome, and are ...
more infohttps://en.wikipedia.org/wiki/Oxytocin
List of enzymes - Wikipedia  List of enzymes - Wikipedia
Category:EC 1.13.11 (With incorporation of two atoms of oxygen) *4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) ... EC 6.2.1.46: [[L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase]] ... Sarcosine oxidase EC 1.5.3.1. *Dihydrobenzophenanthridine oxidase EC 1.5.3.12. *Category:EC 1.5.4 (with a disulfide as acceptor ... Angiotensin converting enzyme. *Category:EC 3.4.21 *Serine protease. *Chymotrypsin (EC 3.4.21.1) ...
more infohttps://en.m.wikipedia.org/wiki/List_of_enzymes
Patente US20070155676 - Substituted azetidinone compounds, processes for preparing the same ... - Google Patentes  Patente US20070155676 - Substituted azetidinone compounds, processes for preparing the same ... - Google Patentes
... angiotensin II receptor antagonists (candesartan, irbesartan, losartan potassium, candesartan cilexetil, telmisartan); anti- ... sarcosine, N-methylisoleucine, 6-N-methyllysine, N-methylvaline, norvaline, norleucine, ornithine and N-methylglycine. ... isoleucine, leucine, lysine, methionine, phenylanine, proline, serine, threonine, tryptophane, tyrosine, valine, 2-aminoadipic ... for individuals with two or more risk factors is ,130 mg/dL (3.37 mmol/L) and for individuals with fewer than two risk factors ...
more infohttp://www.google.es/patents/US20070155676
ȥ쥹 ޡ     /  ǽ??ɾ ??ޡ      ?? ??? ꥹ  : ????Ϸ  ?? 渦 ??   ҥ , ޥ   , ??  ,    ,      , ֥       ,    , 䥮, ͥ  ??оݤȤ    ????   /ʬ??/¬?...  ȥ쥹 ޡ / ǽ??ɾ ??ޡ ?? ??? ꥹ : ????Ϸ ?? 渦 ?? ҥ , ޥ , ?? , , , ֥ , , 䥮, ͥ ??оݤȤ ???? /ʬ??/¬?...
ƥ󥷥 II. ʎ ݎ ގ Îݎ /Angiotensin-2 KAN-748K:154,000 (ELISA ˎ ). ˎ EDTA ???:3,750 ???E. ???. ?? (?? 礻). ... Taurine, Phosphoethanolamine, Aspartic acid, Hydroxyproline, Threonine,Serine, Asparagine, Glutamic acid, Glutamine, Sarcosine ... Isoleucine, Leucine, Tyrosine, Phenylalanine, -Alanine, -Amino-iso-butyric acid, Homocystine, -Amino-n-butyric acid, ... II ( ץ??? ??? ӥ :Factor II). KT-11005:177,000 (ELISA ώ ) ώ ???:18,700 ( Ǿ ?? :10). ???C. ???. (?? 礻). ???. ...
more infohttp://jaica.com/selection_index.html
Aus Klinische Chemie und Laboratoriumsmedizin/Zentrallabor Des Universitätsklinikums des Saarlandes, Homburg/Saar  Aus Klinische Chemie und Laboratoriumsmedizin/Zentrallabor Des Universitätsklinikums des Saarlandes, Homburg/Saar
H oxidasederived reactive oxygen species as mediators of angiotensin II signaling. Antioxidants & Redox Signaling 4: 899-914 76 ... Mudd SH, Ebert MH, Scriver CR (1980) Labile methyl group balances in the human: the role of sarcosine. Metabolism 29: 707-720 ... isoleucine, and valine. Clin Chem 35: 2271-2276 189. Ray JG, Laskin CA (1999) Folic acid and homocyst(e)ine metabolic defects ... Two years later, Mudd et al. and Gibson et al. noted that the homozygous defect of the cystathionine β-synthase is associated ...
more infohttp://spotidoc.com/doc/16413/aus-klinische-chemie-und-laboratoriumsmedizin-zentrallabo
dict.md | D  dict.md | D
... angiotensin II. des-aspartate-angiotensin I. Des-Aspartyl-Angiotensin II. ... des-(glycyl-isoleucine)endozepine. des-(Tyr(1))CM-5. Des-1. Des-1 protein, Drosophila. ... des-AA(1,2,5)-(Glu(7),D-Trp(8),IAmp(9),m-I-Tyr(11),hhLys(12))SRIF. ... sarcosine(4)-. dermorphin (1-5). dermorphin conjugate. dermorphin precursor. dermorphin receptor. ...
more infohttp://en.dict.md/D/90
Pharma Knowledge Base Index - Pharma Knowledge Base  Pharma Knowledge Base Index - Pharma Knowledge Base
1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)Adenine. *1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID ... A B C D E F G H I J K L M N O P Q R S T U V W X Y Z - 0 1 2 3 4 5 6 7 8 9 Α Β ... 1s,3s,4s)-1,3,4-Triphospho-Myo-Inositol. *(1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl] ... 1,5-Dideoxy-1,5-Imino-D-Mannitol. *1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN ...
more infohttp://www.pharmakb.com/pharma-knowledge-base-index/?pgno=1
List of CAS numbers - Page 1535 (185432-00-2 to 186000-44-2)  List of CAS numbers - Page 1535 (185432-00-2 to 186000-44-2)
Angiotensin II C43H75N13O9 185503-97-3 N6-[[4-[[4-(Dimethylamino)phenyl]azo]phenyl]sulfonyl]-N2-[(9H-fluoren-9-ylmethoxy) ... 4-isoleucine,8-isoleucine] ... 1-(Piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one ... 1-(Oxazolo[4,5-b]pyridin-2-yl)ethanone C8H6N2O2 185449-80-3 (S)-N,N-Dimethyl-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4- ... R)-1-(2-Fluorophenyl)ethylamine C8H10FN 185610-53-1 Diphenylcarbamic acid 2-[(2-methyl-1-oxopropyl)amino]-1H-purin-6-yl ester ...
more infohttps://www.chemblink.com/cas/cas1535.htm
What does 1-sarcosine-8-isoleucine angiotensin ii mean?  What does 1-sarcosine-8-isoleucine angiotensin ii mean?
Definition of 1-sarcosine-8-isoleucine angiotensin ii in the Definitions.net dictionary. Meaning of 1-sarcosine-8-isoleucine angiotensin ii. What does 1-sarcosine-8-isoleucine angiotensin ii mean? Information and translations of 1-sarcosine-8-isoleucine angiotensin ii in the most comprehensive dictionary definitions resource on the web.
more infohttp://www.definitions.net/definition/1-sarcosine-8-isoleucine%20angiotensin%20ii
Angiotensin 2 [3-8] Peptide | Abbiotec  Angiotensin 2 [3-8] Peptide | Abbiotec
In response to lowered blood pressure, the renin enzyme cleaves angiotensin-1 from angiotensin. Angiotensin-converting enzyme (ACE) then removes a dipeptide to yield the physiologically active peptide angiotensin-2, the most potent pressor substance known, which helps regulate volume and mineral balance of body fluids. The Angiotensin 2 [3-8] Peptide binds specifically to a new angiotensin binding site distinct from angiotensin 2 receptors.. ...
more infohttp://abbiotec.com/peptides/angiotensin-2-3-8-peptide
  • An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. (mdc-berlin.de)
  • Here, we investigated how the gut microbiota modulates the global metabolic differences in duodenum, jejunum, ileum, colon, liver, and two white adipose tissue depots obtained from conventionally raised (CONV‐R) and germ‐free (GF) mice using gene expression data and tissue‐specific genome‐scale metabolic models (GEMs). (embopress.org)
  • The hormones regulate blood pressure through their natriuretic, diuretic and vasorelaxant activities, as well as inhibition of aldosterone secretion from the adrenal gland, inhibition of renin secretion from the kidney, and functional antagonism of the renin-angiotensin system. (google.com)
  • Infusions of angiotensin II (A II) in either subpressor or pressor amounts potentiated the pressor responses to NE in normal rabbits, whereas, in 3-day clipped rabbits and chronic renal hypertensive rabbits, A II in subpressor or pressor doses did not alter the pressor responses to NE. (ahajournals.org)
  • Maca has been used for centuries in the Andes for nutrition and to enhance fertility in humans and animals [ 1 , 2 ]. (hindawi.com)
  • Also, these results provide evidence that A II plays an important role in the increased pressor responses to NE in hypertensive and prehypertensive rabbits. (ahajournals.org)
  • this A II antagonist did not alter the control arterial pressure in any of the three groups of rabbits. (ahajournals.org)