1-Pyrroline-5-Carboxylate Dehydrogenase
Pyrroline Carboxylate Reductases
A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD(P)H. Includes both the 2-oxidoreductase (EC 1.5.1.1) and the 5-oxidoreductase (EC 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline.
Proline Oxidase
Oxidoreductases Acting on CH-NH Group Donors
Proline
2-Aminoadipic Acid
L-Lysine 6-Transaminase
Spin Trapping
A technique for detecting short-lived reactive FREE RADICALS in biological systems by providing a nitrone or nitrose compound for an addition reaction to occur which produces an ELECTRON SPIN RESONANCE SPECTROSCOPY-detectable aminoxyl radical. In spin trapping, the compound trapping the radical is called the spin trap and the addition product of the radical is identified as the spin adduct. (Free Rad Res Comm 1990;9(3-6):163)
Spin Labels
Free Radicals
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
L-Lactate Dehydrogenase
Alcohol Dehydrogenase
Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition. (1/62)
Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine. We utilized published plant P5CS sequence to search the expressed sequence tag data base and cloned two full-length human P5CS cDNAs differing in length by 6 base pairs (bp) in the open reading frame. The short cDNA has a 2379-bp open reading frame encoding a protein of 793 residues; the long cDNA, generated by "exon sliding," a form of alternative splicing, contains an additional 6-bp insert following bp +711 of the short form resulting in inclusion of two additional amino acids in the region predicted to be the gamma-glutamyl kinase active site of P5CS. The long form predominates in all tissues examined except gut. We also isolated the corresponding long and short murine P5CS transcripts. To confirm the identity of the putative P5CS cDNAs, we expressed both human forms in gamma-glutamyl kinase- and gamma-glutamyl phosphate reductase-deficient strains of Saccharomyces cerevisiae and showed that they conferred the proline prototrophy. Additionally, we found expression of the murine putative P5CS cDNAs conferred proline prototrophy to P5CS-deficient Chinese hamster ovary cells (CHO-K1). We utilized stable CHO-K1 cell transformants to compare the biochemical characteristics of the long and short murine P5CS isoforms. We found that both confer P5CS activity and that the short isoform is inhibited by L-ornithine with a Ki of approximately 0.25 mM. Surprisingly, the long isoform is insensitive to ornithine inhibition. Thus, the two amino acid insert in the long isoform abolishes feedback inhibition of P5CS activity by L-ornithine. (+info)The sfr6 mutation in Arabidopsis suppresses low-temperature induction of genes dependent on the CRT/DRE sequence motif. (2/62)
The sfr mutations, which result in sensitivity to freezing after cold acclimation, define genes that are required for freezing tolerance. We tested plants homozygous for mutations sfr2 to sfr7 for cold-induced gene expression and found that sfr 6 plants were deficient in cold-inducible expression of the genes KIN1, COR15a, and LTI78, which all contain the C repeat/dehydration-responsive element (CRT/DRE) motif in their promoters. Similarly, sfr 6 plants failed to induce KIN1 normally in response to either osmotic stress or the application of abscisic acid. In contrast, cold-inducible expression of genes CBF1, CBF2, CBF3, and ATP5CS1, which lack the CRT/DRE motif, was not affected. The freezing-sensitive phenotype that defines sfr 6 also was found to be tightly linked to the gene expression phenotype. To determine whether the failure of cold induction of CRT/DRE-containing genes in sfr 6 was due to altered low-temperature calcium signaling, cold-induced cytosolic-free calcium ([Ca2+]cyt) elevations were investigated in the sfr 6 mutant, but these were found to be indistinguishable from those of the wild type. We discuss the possibilities that CRT/DRE binding proteins (such as CBF1) require activation to play a role in transcription and that the SFR6 protein is a vital component of their activation. (+info)Proline accumulation in developing grapevine fruit occurs independently of changes in the levels of delta1-pyrroline-5-carboxylate synthetase mRNA or protein. (3/62)
Mature fruit of grapevine (Vitis vinifera) contains unusually high levels of free proline (Pro; up to 24 micromol or 2.8 mg/g fresh weight). Pro accumulation does not occur uniformly throughout berry development but only during the last 4 to 6 weeks of ripening when both berry growth and net protein accumulation have ceased. In contrast, the steady-state levels of both the mRNA encoding V. vinifera Delta1-pyrroline-5-carboxylate synthetase (VVP5CS), a key regulatory enzyme in Pro biosynthesis, and its protein product remain relatively uniform throughout fruit development. In addition, the steady-state protein levels of Pro dehydrogenase, the first enzyme in Pro degradation, increased throughout early fruit development but thereafter remained relatively constant. The developmental accumulation of free Pro late in grape berry ripening is thus clearly distinct from the osmotic stress-induced accumulation of Pro in plants. It is not associated with either sustained increases in steady-state levels of P5CS mRNA or protein or a decrease in steady-state levels of Pro dehydrogenase protein, suggesting that other physiological factors are important for its regulation. (+info)Metabolite repression and inducer exclusion in the proline utilization gene cluster of Aspergillus nidulans. (4/62)
The clustered prnB, prnC, and prnD genes are repressed by the simultaneous presence of glucose and ammonium. A derepressed mutation inactivating a CreA-binding site acts in cis only on the permease gene (prnB) while derepression of prnD and prnC is largely the result of reversal of inducer exclusion. (+info)Removal of feedback inhibition of delta(1)-pyrroline-5-carboxylate synthetase results in increased proline accumulation and protection of plants from osmotic stress. (5/62)
The Delta(1)-pyrroline-5-carboxylate synthetase (P5CS; EC not assigned) is the rate-limiting enzyme in proline (Pro) biosynthesis in plants and is subject to feedback inhibition by Pro. It has been suggested that the feedback regulation of P5CS is lost in plants under stress conditions. We compared Pro levels in transgenic tobacco (Nicotiana tabacum) plants expressing a wild-type form of Vigna aconitifolia P5CS and a mutated form of the enzyme (P5CSF129A) whose feedback inhibition by Pro was removed by site-directed mutagenesis. Transgenic plants expressing P5CSF129A accumulated about 2-fold more Pro than the plants expressing V. aconitifolia wild-type P5CS. This difference was further increased in plants treated with 200 mM NaCl. These results demonstrated that the feedback regulation of P5CS plays a role in controlling the level of Pro in plants under both normal and stress conditions. The elevated Pro also reduced free radical levels in response to osmotic stress, as measured by malondialdehyde production, and significantly improved the ability of the transgenic seedlings to grow in medium containing up to 200 mM NaCl. These findings shed new light on the regulation of Pro biosynthesis in plants and the role of Pro in reducing oxidative stress induced by osmotic stress, in addition to its accepted role as an osmolyte. (+info)Genetic manipulation of the metabolism of polyamines in poplar cells. The regulation of putrescine catabolism. (6/62)
We investigated the catabolism of putrescine (Put) in a non-transgenic (NT) and a transgenic cell line of poplar (Populus nigra x maximowiczii) expressing a mouse (Mus musculus) ornithine (Orn) decarboxylase (odc) cDNA. The transgenic cells produce 3- to 4-fold higher amounts of Put than the NT cells. The rate of loss of Put from the cells and the initial half-life of cellular Put were determined by feeding the cells with [U-(14)C]Orn and [1,4-(14)C]Put as precursors and following the loss of [(14)C]Put in the cells at various times after transfer to label-free medium. The amount of Put converted into spermidine as well as the loss of Put per gram fresh weight were significantly higher in the transgenic cells than the NT cells. The initial half-life of exogenously supplied [(14)C]Put was not significantly different in the two cell lines. The activity of diamine oxidase, the major enzyme involved in Put catabolism, was comparable in the two cell lines even though the Put content of the transgenic cells was severalfold higher than the NT cells. It is concluded that in poplar cells: (a) exogenously supplied Orn enters the cells and is rapidly converted into Put, (b) the rate of Put catabolism is proportional to the rate of its biosynthesis, and (c) the increased Put degradation occurs without significant changes in the activity of diamine oxidase. (+info)A plant gene up-regulated at rust infection sites. (7/62)
Expression of the fis1 gene from flax (Linum usitatissimum) is induced by a compatible rust (Melampsora lini) infection. Infection of transgenic plants containing a beta-glucuronidase (GUS) reporter gene under the control of the fis1 promoter showed that induction is highly localized to those leaf mesophyll cells within and immediately surrounding rust infection sites. The level of induction reflects the extent of fungal growth. In a strong resistance reaction, such as the hypersensitive fleck mediated by the L6 resistance gene, there is very little fungal growth and a microscopic level of GUS expression. Partially resistant flax leaves show levels of GUS expression that were intermediate to the level observed in the fully susceptible infection. Sequence and deletion analysis using both transient Agrobacterium tumefaciens expression and stable transformation assays have shown that the rust-inducible fis1 promoter is contained within a 580-bp fragment. Homologs of fis1 were identified in expressed sequence tag databases of a range of plant species including dicots, monocots, and a gymnosperm. Homologous genes isolated from maize (Zea mays; mis1), barley (Hordeum vulgare; bis1), wheat (Triticum aestivum; wis1), and Arabidopsis encode proteins that are highly similar (76%-82%) to the FIS1 protein. The Arabidopsis homologue has been reported to encode a delta1-pyrroline-5-carboxylate dehydrogenase that is involved in the catabolism of proline to glutamate. RNA-blot analysis showed that mis1 in maize and the bis1 homolog in barley are both up-regulated by a compatible infection with the corresponding species-specific rust. The rust-induced genes homologous to fis1 are present in many plants. The promoters of these genes have potential roles for the engineering of synthetic rust resistance genes by targeting transgene expression to the sites of rust infection. (+info)Molecular mechanisms of proline-mediated tolerance to toxic heavy metals in transgenic microalgae. (8/62)
Pro has been shown to play an important role in ameliorating environmental stress in plants and microorganisms, including heavy metal stress. Here, we describe the effects of the expression of a mothbean delta(1)-pyrroline-5-carboxylate synthetase (P5CS) gene in the green microalga Chlamydomonas reinhardtii. We show that transgenic algae expressing the mothbean P5CS gene have 80% higher free-Pro levels than wild-type cells, grow more rapidly in toxic Cd concentrations (100 microM), and bind fourfold more Cd than wild-type cells. In addition, Cd-K edge extended x-ray absorption fine structure studies indicated that Cd does not bind to free Pro in transgenic algae with increased Pro levels but is coordinated tetrahedrally by sulfur of phytochelatin. In contrast to P5CS-expressing cells, Cd is coordinated tetrahedrally by two oxygen and two sulfur atoms in wild-type cells. Measurements of reduced/oxidized GSH ratios and analyses of levels of malondialdehyde, a product of the free radical damage of lipids, indicate that free Pro levels are correlated with the GSH redox state and malondialdehyde levels in heavy metal-treated algae. These results suggest that the free Pro likely acts as an antioxidant in Cd-stressed cells. The resulting increased GSH levels facilitate increased phytochelatin synthesis and sequestration of Cd, because GSH-heavy metal adducts are the substrates for phytochelatin synthase. (+info)
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Hyperprolinemia and prolinuria in a new inbred strain of mice, pro/re. by R L. Blake and E S. Russell
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Hyperprolinemia
This enzyme helps to break down the pyrroline-5-carboxylate produced in the previous reaction, converting it to the amino acid ... A deficiency of either proline oxidase or pyrroline-5-carboxylate dehydrogenase results in a buildup of proline in the body. A ... This enzyme begins the process of degrading proline by starting the reaction that converts it to pyrroline-5-carboxylate.[ ... Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in ...
List of diseases (D)
Dengue fever Dennis-Cohen syndrome Dennis-Fairhurst-Moore syndrome Dent disease Dental aberrations steroid dehydrogenase ... hypertension Dextrocardia with situs inversus Dextrocardia Dextrocardia-bronchiectasis-sinusitis D-glycerate dehydrogenase ... duplication Digitorenocerebral syndrome Digoxin toxicity Dihydropteridine reductase deficiency Dihydropyrimidine dehydrogenase ... nephrogenic type 1 Diabetes insipidus, nephrogenic type 2 Diabetes insipidus, nephrogenic type 3 Diabetes insipidus, ...
Proline dehydrogenase
In enzymology, proline dehydrogenase (PRODH) (EC 1.5.5.2, formerly EC 1.5.99.8) is an enzyme of the oxidoreductase family, ... It employs one cofactor, FAD, which requires riboflavin (vitamin B2). Proline dehydrogenase is in humans encoded by PRODH and ... Servet C, Ghelis T, Richard L, Zilberstein A, Savoure A (January 2012). "Proline dehydrogenase: a key enzyme in controlling ... Funck D, Eckard S, Müller G (April 2010). "Non-redundant functions of two proline dehydrogenase isoforms in Arabidopsis". BMC ...
1-Pyrroline-5-carboxylic acid
In many prokaryotes, proline dehydrogenase and P5C dehydrogenase form a bifunctional enzyme that prevents the release of P5C ... The enzyme pyrroline-5-carboxylate reductase converts P5C into proline In proline degradation, the enzyme proline dehydrogenase ... "Entrez Gene: ALDH18A1 aldehyde dehydrogenase 18 family, member A1". Liu, Li-Kai; Becker, Donald F.; Tanner, John J. (2017-10-15 ... Heacock, Anne M.; Williams, Irene H.; Frank, Leonard H.; Adams, Elijah (1975-04-01). "Δ1-Pyrroline-5-carboxylate and Δ1- ...
1-Pyrroline-5-carboxylate dehydrogenase
III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218-3223. Portal: Biology (EC 1.2.1, ... L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in ... In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) is an enzyme that catalyzes the chemical reaction (S)-1- ... pyrroline-5-carboxylate + NAD+ + 2 H2O ⇌ {\displaystyle \rightleftharpoons } L-glutamate + NADH + H+ The three substrates of ...
Aldehyde dehydrogenase 4 family, member A1
1998). "Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia". Hum. Mol. Genet. 7 ( ... This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent ... dehydrogenase that catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to ... "Entrez Gene: ALDH4A1 aldehyde dehydrogenase 4 family, member A1". Human ALDH4A1 genome location and ALDH4A1 gene details page ...
Cutis laxa
Aldehyde Dehydrogenase 18 Family, Member A1; ALDH18A1 - 138250 Reddy GP, Mishra B, Upadhyaya DN (2019). "Acquired Localized ... Pyrroline-5-Carboxylate Reductase 1; PYCR1 - 179035 Online Mendelian Inheritance in Man (OMIM): ... 8 (1): 42-51. doi:10.1159/000443696. PMC 4899661. PMID 27293393. Bouloc A, Godeau G, Zeller J, Wechsler J, Revuz J, Cosnes A ( ... 64 (1): 55-58. doi:10.4103/ijd.IJD_14_18. PMC 6340237. PMID 30745636. Rongioletti F, Cutolo M, Bondavalli P, Rebora A (January ...
Proline
Muzammil S, Shrestha A, Dadshani S, Pillen K, Siddique S, Léon J, Naz AA (October 2018). "An Ancestral Allele of Pyrroline-5- ... carboxylate synthase1 Promotes Proline Accumulation and Drought Adaptation in Cultivated Barley". Plant Physiology. 178 (2): ... which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine ... 34 (5): 681-701.e10. doi:10.1016/j.cmet.2022.04.001. hdl:10230/53513. PMID 35508109. S2CID 248528026. Pavlov MY, Watts RE, Tan ...
Pyrrole
For example, Birch reduction of pyrrole esters and amides produced pyrrolines, with the regioselectivity depending on the ... Structural analogs of pyrrole include: Pyrroline, a partially saturated analog with one double bond Pyrrolidine, the saturated ... which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine ... Pyrroles can undergo reductions to pyrrolidines and to pyrrolines. ...
Arginine and proline metabolism
... which is reduced to proline by pyrroline-5-carboxylate reductase (using NADH or NADPH), or turned into ornithine by ornithine ... Glutamate-5-semialdehyde is first formed by glutamate 5-kinase (ATP-dependent) and glutamate-5-semialdehyde dehydrogenase ( ... which requires NADH or NADPH). This can then either spontaneously cyclize to form 1-pyrroline-5-carboxylic acid, ... ISBN 1-57259-153-6.. (Proteinogenic amino acids, Basic amino acids). ...
PYCR1
Pyrroline-5-carboxylate reductase 1, mitochondrial is an enzyme that in humans is encoded by the PYCR1 gene. This gene encodes ... "Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1". Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng SC, Li ... Meng Z, Lou Z, Liu Z, Li M, Zhao X, Bartlam M, Rao Z (June 2006). "Crystal structure of human pyrroline-5-carboxylate reductase ... Yeh GC, Roth EF, Phang JM, Harris SC, Nagel RL, Rinaldi A (May 1984). "The effect of pyrroline-5-carboxylic acid on nucleotide ...
Aldehyde dehydrogenase 18 family, member A1
Hu CA, Khalil S, Zhaorigetu S, Liu Z, Tyler M, Wan G, Valle D (November 2008). "Human Delta1-pyrroline-5-carboxylate synthase: ... The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo ... This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial ... "Entrez Gene: ALDH18A1 aldehyde dehydrogenase 18 family, member A1". Fischer-Zirnsak B, Escande-Beillard N, Ganesh J, Tan YX, Al ...
List of MeSH codes (D08)
... pyrroline carboxylate reductases MeSH D08.811.682.662.750 - saccharopine dehydrogenases MeSH D08.811.682.662.825 - ... malate dehydrogenase MeSH D08.811.682.047.748 - malate dehydrogenase (nadp+) MeSH D08.811.682.047.892 - xanthine dehydrogenase ... acetoin dehydrogenase MeSH D08.811.682.047.070 - alcohol dehydrogenase MeSH D08.811.682.047.150 - carbohydrate dehydrogenases ... acyl-coa dehydrogenase MeSH D08.811.682.660.150.150 - acyl-coa dehydrogenase, long-chain MeSH D08.811.682.660.150.200 - acyl- ...
Nicotinamide adenine dinucleotide
"Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of ... including glyceraldehyde 3-phosphate dehydrogenase and pyruvate dehydrogenase. In healthy mammalian tissues, estimates of the ... Lesk AM (1995). "NAD-binding domains of dehydrogenases". Curr. Opin. Struct. Biol. 5 (6): 775-83. doi:10.1016/0959-440X(95) ... ISBN 978-0-911910-27-8. Biellmann JF, Lapinte C, Haid E, Weimann G (1979). "Structure of lactate dehydrogenase inhibitor ...
Biosynthesis
Pyrroline-5-carboxylate is further reduced by the enzyme pyrroline-5-carboxylate reductase (P5CR) to yield a proline amino acid ... Aspartate-semialdehyde dehydrogenase catalyzes the reduction reaction by dephosphorylation of aspartyl-β-phosphate to yield ... kinase catalyzes the initial step in the diaminopimelic acid pathway by transferring a phosphoryl from ATP onto the carboxylate ... The next reaction is catalyzed by the enzyme pyrroline-5-carboxylate synthase (P5CS), which catalyzes the reduction of the ϒ- ...
Bruno Reversade
2015-09-03). "Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form ... January 30, 2020). "Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic ... ISBN 978-1-107-00382-8 - via Google Books. Rosier, Florence (8 July 2014). "Sur la piste d'un gène responsable de la gémellité ... 167 (1): 187-202.E17. doi:10.1016/j.cell.2016.09.001. PMID 27662089. Zhonga, Franklin L.; Robinson, Kim; Teo, Daniel Eng Thiam ...
List of EC numbers (EC 1)
... benzaldehyde dehydrogenase (NAD+) EC 1.2.1.29: aryl-aldehyde dehydrogenase EC 1.2.1.30: carboxylate reductase (NADP+) EC 1.2. ... pyrroline-5-carboxylate reductase EC 1.5.1.3: dihydrofolate reductase EC 1.5.1.4: Now included with EC 1.5.1.3 dihydrofolate ... EC 1.1.1.1: alcohol dehydrogenase EC 1.1.1.2: alcohol dehydrogenase (NADP+) EC 1.1.1.3: homoserine dehydrogenase EC 1.1.1.4: (R ... formylmethanofuran dehydrogenase EC 1.2.99.6: carboxylate reductase EC 1.2.99.7: aldehyde dehydrogenase (FAD-independent) EC ...
List of EC numbers (EC 3)
... pyruvate dehydrogenase (acetyl-transferring)]-phosphatase EC 3.1.3.44: [acetyl-CoA carboxylase]-phosphatase EC 3.1.3.45: 3- ... 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase EC 3.1.3.53: [myosin-light-chain] ... EC 3.2.1.91: cellulose 1,4-β-cellobiosidase (non-reducing end) EC 3.2.1.92: peptidoglycan β-N-acetylmuramidase EC 3.2.1.93: α,α ... EC 3.4.21.60 EC 3.4.21.60, scutelarin EC 3.4.99.29: Deleted entry: Myxobacter AL-1 proteinase I EC 3.4.99.30: Transferred entry ...
IMSEAR at SEARO: Modulation of proline metabolism under drought and salt stress conditions in wheat seedlings
Water withholding condition induced the stimulation of proline synthesis via increased glutamate dehydrogenase (GDH), pyrroline ... Glutamate dehydrogenase might have played a dominant role in ammonium assimilation and glutamate biosynthesis, leading to an ... which via pyrroline-5-carboxylate synthetase activity led to enhanced proline accumulation in tolerant genotypes under stress ... and pyrroline-5-carboxylate reductase (P5CR) activities with inhibition of oxidation via reduced proline dehydrogenase activity ...
IMSEAR at SEARO: Modulation of proline metabolism under drought and salt stress conditions in wheat seedlings
Water withholding condition induced the stimulation of proline synthesis via increased glutamate dehydrogenase (GDH), pyrroline ... Glutamate dehydrogenase might have played a dominant role in ammonium assimilation and glutamate biosynthesis, leading to an ... which via pyrroline-5-carboxylate synthetase activity led to enhanced proline accumulation in tolerant genotypes under stress ... and pyrroline-5-carboxylate reductase (P5CR) activities with inhibition of oxidation via reduced proline dehydrogenase activity ...
Genomics (A-Z)|Home|PHGKB
Dihydropyrimidine dehydrogenase deficiency. *Dihydroxyadeninuria. *Dilated cardiomyopathy. *Dilated cardiomyopathy with ...
Code System Concept
1-Pyrroline-5-carboxylate dehydrogenase Active Synonym false false 3720748015 1-pyrroline-5-carboxylate dehydrogenase Active ... 1-pyrroline-5-carboxylate dehydrogenase (substance). Code System Preferred Concept Name. 1-pyrroline-5-carboxylate ... dehydrogenase (substance). Concept Status. Published. Concept Status Date. 09/01/2022. Code System Name. SNOMED-CT ...
Hyperprolinemia: MedlinePlus Genetics
Pyrroline carboxylate dehydrogenase deficiency. *Pyrroline-5-carboxylate dehydrogenase deficiency. Additional Information & ... Variants in either the PRODH or ALDH4A1 gene can cause a reduction in proline dehydrogenase or pyrroline-5-carboxylate ... This enzyme helps to break down the pyrroline-5-carboxylate produced in the previous reaction, converting it to the amino acid ... This enzyme begins the process of breaking down proline by starting the reaction that converts proline to pyrroline-5- ...
IMSEAR at SEARO: Modulation of proline metabolism under drought and salt stress conditions in wheat seedlings
Water withholding condition induced the stimulation of proline synthesis via increased glutamate dehydrogenase (GDH), pyrroline ... Glutamate dehydrogenase might have played a dominant role in ammonium assimilation and glutamate biosynthesis, leading to an ... which via pyrroline-5-carboxylate synthetase activity led to enhanced proline accumulation in tolerant genotypes under stress ... and pyrroline-5-carboxylate reductase (P5CR) activities with inhibition of oxidation via reduced proline dehydrogenase activity ...
MedlinePlus: Genetic Conditions: P
Pyrroline carboxylate dehydrogenase deficiency, see Hyperprolinemia. *Pyrroline-5-carboxylate dehydrogenase deficiency, see ... Pseudohermaphroditism, male, with gynecomastia, see 17-beta hydroxysteroid dehydrogenase 3 deficiency. *Pseudohypoaldosteronism ... Premature ovarian failure 1, see Fragile X-associated primary ovarian insufficiency. *Presbyacusia, see Age-related hearing ... PAI-1 deficiency, see Complete plasminogen activator inhibitor 1 deficiency. *PAI-1D, see Complete plasminogen activator ...
ALDH4A1 gene: MedlinePlus Genetics
The ALDH4A1 gene provides instructions for producing the enzyme pyrroline-5-carboxylate dehydrogenase, which is found in ... Pyrroline-5-carboxylate dehydrogenase starts the second step in the process that breaks down the protein building block (amino ... Yoshida A, Rzhetsky A, Hsu LC, Chang C. Human aldehyde dehydrogenase gene family. Eur J Biochem. 1998 Feb 1;251(3):549-57. doi ... A lack of pyrroline-5-carboxylate dehydrogenase function leads to decreased breakdown of proline and elevated levels of proline ...
ALDH18A1 gene: MedlinePlus Genetics
A missense mutation in ALDH18A1, encoding Delta1-pyrroline-5-carboxylate synthase (P5CS), causes an autosomal recessive ... ALDEHYDE DEHYDROGENASE 18 FAMILY, MEMBER A1. Gene and Variant Databases. *NCBI Gene ... Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal- ... The P5CS protein carries out the first step in this process by converting the amino acid glutamate to glutamate 5-semialdehyde ...
MedlinePlus: Genes: P
PDHX: pyruvate dehydrogenase complex component X. *PDP1: pyruvate dehydrogenase phosphatase catalytic subunit 1 ... PYCR1: pyrroline-5-carboxylate reductase 1. *PYGL: glycogen phosphorylase L. *PYGM: glycogen phosphorylase, muscle associated ... PKD1: polycystin 1, transient receptor potential channel interacting. *PKD2: polycystin 2, transient receptor potential cation ... PIK3CD: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta. *PIK3R1: phosphoinositide-3-kinase regulatory ...
Hyperprolinemia: MedlinePlus Genetics
Pyrroline carboxylate dehydrogenase deficiency. *Pyrroline-5-carboxylate dehydrogenase deficiency. Additional Information & ... Variants in either the PRODH or ALDH4A1 gene can cause a reduction in proline dehydrogenase or pyrroline-5-carboxylate ... This enzyme helps to break down the pyrroline-5-carboxylate produced in the previous reaction, converting it to the amino acid ... This enzyme begins the process of breaking down proline by starting the reaction that converts proline to pyrroline-5- ...
IMSEAR at SEARO: Modulation of proline metabolism under drought and salt stress conditions in wheat seedlings
Water withholding condition induced the stimulation of proline synthesis via increased glutamate dehydrogenase (GDH), pyrroline ... Glutamate dehydrogenase might have played a dominant role in ammonium assimilation and glutamate biosynthesis, leading to an ... which via pyrroline-5-carboxylate synthetase activity led to enhanced proline accumulation in tolerant genotypes under stress ... and pyrroline-5-carboxylate reductase (P5CR) activities with inhibition of oxidation via reduced proline dehydrogenase activity ...
1-Pyrroline-5-Carboxylate Dehydrogenase | Colorado PROFILES
An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. Defects in the ... "1-Pyrroline-5-Carboxylate Dehydrogenase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus ... This graph shows the total number of publications written about "1-Pyrroline-5-Carboxylate Dehydrogenase" by people in this ... Below are the most recent publications written about "1-Pyrroline-5-Carboxylate Dehydrogenase" by people in Profiles. ...
GO:0003842: 1-pyrroline-5-carboxylate dehydrogenase activity details
ALDH4A1 gene: MedlinePlus Genetics
The ALDH4A1 gene provides instructions for producing the enzyme pyrroline-5-carboxylate dehydrogenase, which is found in ... Pyrroline-5-carboxylate dehydrogenase starts the second step in the process that breaks down the protein building block (amino ... Yoshida A, Rzhetsky A, Hsu LC, Chang C. Human aldehyde dehydrogenase gene family. Eur J Biochem. 1998 Feb 1;251(3):549-57. doi ... A lack of pyrroline-5-carboxylate dehydrogenase function leads to decreased breakdown of proline and elevated levels of proline ...
Code System Concept
1-Pyrroline-5-carboxylate dehydrogenase Active Synonym false false 3720748015 1-pyrroline-5-carboxylate dehydrogenase Active ... 1-pyrroline-5-carboxylate dehydrogenase (substance). Code System Preferred Concept Name. 1-pyrroline-5-carboxylate ... dehydrogenase (substance). Concept Status. Published. Concept Status Date. 09/01/2022. Code System Name. SNOMED-CT ...
DeCS
Pyrroline Carboxylate Reductases [D08.811.682.662.695] Pyrroline Carboxylate Reductases * Saccharopine Dehydrogenases [D08.811. ... Dehydrogenase, GGS Dehydrogenase, Glutamic-Gamma-Semialdehyde Dehydrogenase, Glutamyl-Gamma-Semialdehyde Delta(1)-Pyrroline-5- ... Carboxylate Dehydrogenase GGS Dehydrogenase Glutamic Gamma Semialdehyde Dehydrogenase Glutamic-Gamma-Semialdehyde Dehydrogenase ... Dehydrogenase, GGS. Dehydrogenase, Glutamic-Gamma-Semialdehyde. Dehydrogenase, Glutamyl-Gamma-Semialdehyde. Delta(1)-Pyrroline- ...
Finding step rocA for L-citrulline catabolism in Echinicola vietnamensis KMM 6221, DSM 17526
P5C dehydrogenase 2; L-glutamate gamma-semialdehyde dehydrogenase; EC 1.2.1.88 (characterized). 33%. 90%. 220.7. aldehyde ... L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) (characterized). 49%. 94%. 515.8. delta-1-pyrroline-5-carboxylate ... 2 candidates for rocA: 1-pyrroline-5-carboxylate dehydrogenase. Score. Gene. Description. Similar to. Id.. Cov.. Bits. Other ... dehydrogenase [NAD(P)+] (EC 1.2.1.5). 69%. 731.1. Confidence: high confidence medium confidence low confidence. transporter - ...
Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in...
On one hand, nitrogen deprivation induced the down-regulation of isocitrate dehydrogenase level in TCA cycle and redirected ... Combining with the up-regulation of glutamate decarboxylase and succinic semialdehyde dehydrogenase in GABA shunt, and the ... MDH, malate dehydrogenase, GDH, glutamate dehydrogenase, SSADH, succinate-semialdehyde dehydrogenase, PLC, Phospholipase C, PLD ... Most of the enzymes involved in the TCA cycle, especially isocitrate dehydrogenase (IDH), were rapidly decreased in response to ...
DeCS 2013 - December 17, 2013 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-diHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
Bio2Vec
Pre GI: CDS description
Find your antibody within.
P5C dehydrogenase; EC 1.2.1.88; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase; ... Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.-; aldh8a1; NP_001004540.1 487 zebrafish ... APC membrane recruitment protein 1; Amer1; Protein FAM123B; amer1; fam123b; NULL 930 zebrafish ... GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; EC 2.4.1.131; Asparagine-linked glycosylation protein 11 homolog ...
SustainPineDB
AutoFact: Aldehyde dehydrogenase n=1 Tax=Volvox carteri f. nagariensis RepID=D8UHH5_VOLCA 1.0e-11 ... AutoFact: Putative aldehyde dehydrogenase n=1 Tax=Oryza sativa Japonica Group RepID=Q6L5I4_ORYSJ 0.0 ... FL-Next: sp=Probable aldehyde dehydrogenase; Linum usitatissimum (Flax) (Linum humile). 0.0 ... AutoFact: Probable aldehyde dehydrogenase n=1 Tax=Linum usitatissimum RepID=ALDH_LINUS 0.0 ...
SA0934 - AureoWiki
pyruvate dehydrogenase E1 component subunit alpha [2] (data from MRSA252). SA1938. (pdp). pyrimidine-nucleoside phosphorylase [ ... glyceraldehyde-3-phosphate dehydrogenase [2] (data from MRSA252). SA1959. (glmS). glucosamine--fructose-6-phosphate ... 1-pyrroline-5-carboxylate dehydrogenase [2] (data from MRSA252). SA0496. (rplA). 50S ribosomal protein L1 [2] (data from ... 1 61 121 181 241 ATGGAACAAAATTCATATGTAATCATCGACGAGACTGGTATTCACGCTAGACCAGCAACA. ATGTTAGTACAAACAGCTTCAAAATTCGATTCTGATATTC ...
Network Portal - Gene GSU1723
proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase (NCBI). 178, 294. GSU3460. GSU3460. glycosyl transferase, ... POSITION A C G T 1 0.4 0.6 0.0 0.0 2 0.8 0.0 0.0 0.2 3 0.0 0.6 0.4 0.0 4 0.0 0.2 0.8 0.0 5 0.0 0.0 0.2 0.8 6 0.0 0.0 0.0 1.0 7 ... POSITION A C G T 1 0.0 1.0 0.0 0.0 2 0.0 0.875 0.125 0.0 3 0.75 0.0 0.0 0.25 4 0.25 0.5 0.125 0.125 5 0.0 0.0 0.0 1.0 6 0.0 0.0 ... POSITION A C G T 1 0.125 0.0 0.0 0.875 2 0.75 0.125 0.0 0.125 3 1.0 0.0 0.0 0.0 4 0.875 0.125 0.0 0.0 5 0.5 0.0 0.5 0.0 6 0.75 ...
gpuA protein (Pseudomonas aeruginosa) - STRING interaction network
Rhh-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5- ... carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source ... Rhh-type transcriptional regulator, proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5- ... carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source ...
Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathways | BMC Systems...
As a technical note, consider that FAD/FADH2 is tightly bound to a protein, in our case to D-amino acid dehydrogenase (DAAD) in ... and pyrroline-5-carboxylate reductase (P5CR)). This pathway represents the canonical biosynthetic mechanisms of L-Pro [59]. ... homoserine dehydrogenase (NADPH); HSK, homoserine kinase; NACODA, N-acetylornithine deacetylase; PDH, pyruvate dehydrogenase; ... aldehyde dehydrogenase (acetaldehyde, NAD); ASAD, aspartate-semialdehyde dehydrogenase; ASPK, aspartate kinase; ASPTA, ...
Genes | Free Full-Text | Impacts of the Type I Toxin-Antitoxin System, SprG1/SprF1, on Staphylococcus aureus Gene Expression
Pyruvate dehydrogenase E1 component subunit β (PdhB). P99063. 1.84 ↓. 2.23 ↓. 12. Dihydrolipoyl dehydrogenase (PdhD). P99084. ... Glyceraldehyde-3-phosphate dehydrogenase 1 (GapA1). P99136. 1.62 ↓. * the arrow denotes the direction of regulation; ↑ up- and ... Glyceraldehyde-3-phosphate dehydrogenase 1 (GapA1). P99136. 1.5 ↓. 16. 3-hexulose-6-phosphate synthase (HPS). Q7A774. 1.92 ↓. ... Pyruvate dehydrogenase E1 component subunit β (PdhB). P99063. 2.19 ↓. 1.82 ↓. 2. Succinate--CoA ligase (ADP-forming) subunit α ...
October 2016
SMPDB
carboxylate. dehydrogenase,. mitochondrial. Proline. dehydrogenase. 1,. mitochondrial. Pyrroline-5-. carboxylate. reductase 2. ... Pyrroline hydroxycarboxylic. acid. NAD. NADH. ATP. AMP. PP. i. Glycine. Ornithine. Dissipation. Guanidoacetic acid. S- ... 1-Pyrroline-2-carboxylic acid. NH. 3. H. 2. O. 2. H. 2. O. O. 2. 1-Pyrroline-4-hydroxy-2-. carboxylate. NH. 3. H. 2. O. 2. NAD ... 1-Pyrroline-5-carboxylic acid. NAD. H. 2. O. NADH. L-Proline. NAD. NADH. Oxoglutaric acid. O. 2. 4-Hydroxyproline. Succinic ...
Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureus | BMC Microbiology | Full Text
Also succinate dehydrogenase (sdhB), succinyl-CoA synthetase (sucCD), and 2-oxoglutarate dehydrogenase (odhAB) were repressed ... glyceraldehyde-3-phosphate dehydrogenase; gapB, glyceraldehyde-3-phosphate dehydrogenase; glcK, glucokinase; mqo2, malate: ... 2-oxoglutarate dehydrogenase component E2; pckA, phosphoenolpyruvate carboxykinase; pdhABCD, pyruvate dehydrogenase; pfk, ... The genes coding for alanine dehydrogenase (ald), aldehyde dehydrogenase (aldA), arginase (arg), and delta-1-pyrroline-5- ...
Búsqueda | BVS Nicaragua
... such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), trypsin-1, and delta-1-pyrroline-5-carboxylate synthase (ALDH18A1). ... 5. Transcriptome analysis of the hepatopancreas in Penaeus vannamei under experimental infection with Enterocytozoon ... Satellite cells were isolated from the p. major muscle of 1-week-old faster-growing modern-commercial (NC) turkeys and slower- ... CO2 adsorption experiments show that (Br-)CH3-Pyridinium-MOF-1 has a higher affinity for CO2 than its electrically neutral ...
DeCS 2014 - December 16, 2014 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-diHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
DeCS 2011 - December 22, 2011 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-diHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
DeCS 2014 - December 16, 2014 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-diHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
DeCS 2016 - July 28, 2016 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-diHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
DeCS 2009 - February 20, 2009 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 3,5-Cyclic-Nucleotide Phosphodiesterase use 3,5-Cyclic-AMP Phosphodiesterases 3-alpha-Hydroxysteroid Dehydrogenase (B- ...
DeCS 2010 - February 12, 2010 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
DeCS 2012 - February 22, 2012 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-diHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
DeCS 2010 - February 12, 2010 version
2-Oxoisovalerate Dehydrogenase (Acylating) 2-Oxoisovalerate Dehydrogenase (Lipoamide) use 3-Methyl-2-Oxobutanoate Dehydrogenase ... 2-Amino-5-phosphonovaleric Acid use 2-Amino-5-phosphonovalerate 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone use ... 5,10-Methylenetetrahydrofolate-Reductase (NADH) use Methylenetetrahydrofolate Dehydrogenase (NAD+) 5,12-DiHETE use Leukotriene ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ...
ReductaseSynthetaseMitochondrialGlutamatePutativeEnzymeProlineAldehyde dehydrogenasesGenesProteinChromosomeAcidSynthesisCharacterizationPROFILESAlpha-1,2-mannosyltransferaseMetabolicKinaseReactionsSymbolFAMILYDelta 1-pyrroline-5-carboxylateSynthetaseBetaine aldehyde dehySemialdehyde DehydrogenaseConvertsPutativeNADHALDH4A1Glutamate dehydrogenaseAmino acidReactionSuperfamilyGenePyridoxineSuccinate semialdehydePathwayVulgarisMutationsHydrolaseType
Reductase3
- aldo-keto reductase family 1 member B15. (gsea-msigdb.org)
- Water withholding condition induced the stimulation of proline synthesis via increased glutamate dehydrogenase (GDH), pyrroline-5-carboxylate synthetase (P5CS) and pyrroline-5-carboxylate reductase (P5CR) activities with inhibition of oxidation via reduced proline dehydrogenase activity to a large extent as compared to water deficit and salt stress conditions. (who.int)
- In particular, the stress-induced increase in the transfer of reducing equivalents into proline by Δ¹-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) may be a protective mechanism whereby many species ameliorate shifts in cellular redox potential which accompany all biotic and abiotic stresses which cause proline accumulation, including those that do not cause cellular dehydration. (ukzn.ac.za)
Synthetase1
- Glutamate dehydrogenase might have played a dominant role in ammonium assimilation and glutamate biosynthesis, leading to an increased glutamate pool, which via pyrroline-5-carboxylate synthetase activity led to enhanced proline accumulation in tolerant genotypes under stress conditions. (who.int)
Mitochondrial1
- Afterwards, the semen was cooled to 5 °C for 2 h, after that period, filled in 0.5 mL straws and then placed under liquid nitrogen vapor (N L), 8 cm from 2 the liquid sheet for 15 min, and then immersed on the N L. The samples were analyzed for sperm motility, plasma membrane and 2 acrosomal membrane integrity, mitochondrial activity and binding test. (bvsalud.org)
Glutamate8
- An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. (ucdenver.edu)
- This step converts pyrroline-5-carboxylate, which is produced in the first step, to the amino acid glutamate. (medlineplus.gov)
- Combining with the up-regulation of glutamate decarboxylase and succinic semialdehyde dehydrogenase in GABA shunt, and the phosphoenolpyruvate carboxykinase in the central hub involving pyruvate/phosphoenolpyruvate/oxaloacetate, the products from nitrogen-containing compounds degradation were recycled to be intermediates of TCA cycle and be shunted toward de novo biosynthesis of fatty acids. (biomedcentral.com)
- NADP-dependent glutamate dehydrogenase (NADP-GDH) was purified to homogeneity from Pseudomonas aeruginosa strain 8602 (PAC 1). (microbiologyresearch.org)
- It was concluded that NADP-GDH is not essential for growth of the wild-type organism and that glutamate formation via NAD-dependent glutamate dehydrogenase does not occur to a significant extent. (microbiologyresearch.org)
- Mutants of Klebsiella aerogenes lacking glutamate dehydrogenase. (microbiologyresearch.org)
- Salmonella typhimurium mutants with altered glutamate dehydrogenase and glutamate synthase activities. (microbiologyresearch.org)
- Characterization of glutamate dehydrogenase from the ammonia oxidizing chemoautotroph Nitromonas europaea. (microbiologyresearch.org)
Putative1
- XV" YOL105C 1 15 18 YOL105C "Putative integral membrane protein containing novel cysteine motif. (davidson.edu)
Enzyme3
- The ALDH4A1 gene provides instructions for producing the enzyme pyrroline-5-carboxylate dehydrogenase, which is found in tissues throughout the body. (medlineplus.gov)
- ALDH4A1 gene variants reduce or eliminate the function of the pyrroline-5-carboxylate dehydrogenase enzyme. (medlineplus.gov)
- Here, we show that a single point mutation (Q201) in the Acinetobacter baumannii xanthine oxidase (AbXOD) obtained mutant Q201E (k cat =799.44 s-1, no inhibition) with high enzyme activity and decrease of substrate inhibition in 5 mmol/L high substrate model, and which cause two loops structure change at active center, characterized by complete loss of substrate inhibition without reduction of enzymatic activity. (bvsalud.org)
Proline4
- Pyrroline-5-carboxylate dehydrogenase starts the second step in the process that breaks down the protein building block (amino acid) proline. (medlineplus.gov)
- A lack of pyrroline-5-carboxylate dehydrogenase function leads to decreased breakdown of proline and elevated levels of proline and intermediate breakdown product pyrroline-5-carboxylate, causing the signs and symptoms of hyperprolinemia type II. (medlineplus.gov)
- Tolerant genotypes possessed increased proline content and 1,1 diphenyl-picryl hydrazyl (DPPH) radical scavenging activity along with the reduced magnitude of thiobarbituric acid reactive species in parallel with decreased H2O2 content. (who.int)
- Transgenic plants, which were selected on the basis of kanamycin resistance, regenerated at a low frequency in the presence of 1 mM proline. (ukzn.ac.za)
Aldehyde dehydrogenases1
- Vasiliou V, Pappa A. Polymorphisms of human aldehyde dehydrogenases. (medlineplus.gov)
Genes3
- Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. (medlineplus.gov)
- Sequence homologies of several regions within the 5' untranslated regions of these genes to promoter elements which have been shown to participate in redox control of gene expression, the actions of phytochrome and hormones, and tissue-specific regulation of gene expression are also identified. (ukzn.ac.za)
- Transcriptomics-based expressions of genes encoding different types of SNF1 (sucrose non-fermenting 1)-related kinases involved in sugar and stress signaling or encoding key metabolic enzymes were in line with specific qRT-PCR analysis or with the important metabolic and regulatory changes revealed by metabolomic analysis. (frontiersin.org)
Protein6
- One of the important and highly conserved regulators of carbon catabolite regulation in low-GC Gram-positive bacteria is the catabolite control protein A, CcpA, which has been intensively studied in Bacillus subtilis [ 1 , 2 ]. (biomedcentral.com)
- limb development membrane protein 1 [So. (gsea-msigdb.org)
- expressed in middle/late meiosis,IV" YDR525W 1 5 7 YDR525W "Ydr525wp,IV" YDR526C 1 5 8 YDR526C "Ydr526cp,IV" YER187W 1 5 9 YER187W "similar to killer toxin,V" YER188W 1 5 10 YER188W "Yer188wp,V" YER190W 1 5 11 YER190W "Yrf1-2p,V" YFL002C 1 5 12 YFL002C "ATP-dependent RNA helicase,VI" YFL002W-B 1 5 13 YFL002W-B "TyA gag protein. (davidson.edu)
- contains a zinc finger,XV" YOL091W 1 15 16 YOL091W "involved in sporulation,XV" YOL103W-B 1 15 17 YOL103W-B "TyB Gag-Pol protein. (davidson.edu)
- XIII" YMR047C 3 13 3 YMR047C "Nuclear pore complex protein that is member of GLFG repeat-containing family of nucleoporins and is,XIII" YMR049C 3 13 4 YMR049C "Ymr049cp,XIII" YMR051C 3 13 5 YMR051C "TyA Gag protein. (davidson.edu)
- Penicillin-binding protein 5, D-alanyl-D-alanine carboxypeptidase [Interproscan]. (ntu.edu.sg)
Chromosome2
- The ALDH4A1 gene is found on chromosome 1 . (medlineplus.gov)
- chromosome 5 open reading frame 24 [Sou. (gsea-msigdb.org)
Acid3
- For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. (lbl.gov)
- 1. Cerutti, P. and Guroff, G. Enzymatic formation of phenylpyruvic acid in Pseudomonas sp. (qmul.ac.uk)
- enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase. (qmul.ac.uk)
Synthesis1
- In addition, enteral or parenteral cystine, methionine, N-acetyl-cysteine, and L-2-oxothiazolidine-4-carboxylate are effective precursors of cysteine for tissue GSH synthesis. (researchgate.net)
Characterization1
- Hu CA, Lin WW, Valle D. Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase. (medlineplus.gov)
PROFILES1
- Below are the most recent publications written about "1-Pyrroline-5-Carboxylate Dehydrogenase" by people in Profiles. (ucdenver.edu)
Alpha-1,2-mannosyltransferase1
- ALG9 alpha-1,2-mannosyltransferase [Sou. (gsea-msigdb.org)
Metabolic1
- It is now well established that the metabolic reprogramming undergone by transformed cells extends far beyond glycolysis and the Warburg effect, and changes in cell metabolism have fundamental implications for tumor biology and therapy [ 5 , 6 ]. (biomedcentral.com)
Kinase1
- casein kinase 1 gamma 1 [Source:HGNC Sy. (gsea-msigdb.org)
Reactions1
- L-1-pyrroline-3-hydroxy-5-carboxylate = 13 reactions were found. (tu-bs.de)
Symbol3
- derlin 2 [Source:HGNC Symbol;Acc:HGNC:1. (gsea-msigdb.org)
- glycogenin 1 [Source:HGNC Symbol;Acc:HG. (gsea-msigdb.org)
- HIVEP zinc finger 1 [Source:HGNC Symbol. (gsea-msigdb.org)
FAMILY1
- Aldehyde dehydrogenase family [Interproscan]. (ntu.edu.sg)
Delta 1-pyrroline-5-carboxylate1
- The role of Delta(1)-Pyrroline-5-carboxylate dehydrogenase in proline degradation. (mpg.de)
Synthetase2
- Instead, we discovered that the glutamate-consuming enzymes phosphoserine aminotransferase 1 (PSAT1) and aldehyde dehydrogenase 18A1 (ALDH18A1)/Δ1-pyrroline-5-carboxylate synthetase (P5CS) are required for collagen protein production by lung fibroblasts. (nih.gov)
- Chandrakar V., Keshavkant S. (2018): Nitric oxide and dimethylthiourea up-regulates pyrroline-5-carboxylate synthetase expression to improve arsenic tolerance in Glycine max L. Environmental Progress and Sustainable Energy, 38: 402-409. (agriculturejournals.cz)
Betaine aldehyde dehy1
- betaine aldehyde dehydrogenase [Sua. (cornell.edu)
Semialdehyde Dehydrogenase2
Converts4
- This step converts pyrroline-5-carboxylate, which is produced in the first step, to the amino acid glutamate. (medlineplus.gov)
- Or as part of L-arginine degradation I, the aminotransferase rocD converts ornithine to glutamate 5-semialdehyde, which spontaneously converts to 1-pyrroline-5-carboxylate. (lbl.gov)
- A dehydrogenase converts this to glutamate. (lbl.gov)
- Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. (nih.gov)
Putative4
- putative zinc-binding dehydrogenase [Pec. (virginia.edu)
- putative alcohol dehydrogenase [Salmonel. (virginia.edu)
- Glycine max putative E3 ubiquitin-protein ligase UBR7-like (LOC100817441), transcript variant 1, mRNA. (go.jp)
- Glycine max putative cyclin-D6-1-like (LOC100799951), mRNA. (go.jp)
NADH2
- NADH, also known as DPNH or b-nadh, belongs to the class of organic compounds known as (5'->5')-dinucleotides. (ymdb.ca)
- YP_007353830.1 [mitochondrion Moschus chrysogaster]NADH dehydrogenase subunit 1 (mitochondrion) [Moschus chrysogaster]. (vital-it.ch)
ALDH4A12
- The ALDH4A1 gene is found on chromosome 1 . (medlineplus.gov)
- Structural Studies of Yeast Delta-Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State. (proteopedia.org)
Glutamate dehydrogenase1
- We found that metabolism of glutamate to α-ketoglutarate by glutamate dehydrogenase or the glutamate-pyruvate or glutamate-oxaloacetate transaminases is not required for collagen protein production. (nih.gov)
Amino acid1
- For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. (lbl.gov)
Reaction1
- As an initial step in understanding the biochemistry of human P5CDh and molecular basis of HPII, we utilized published peptide sequence data and degenerate primer polymerase chain reaction to clone two full-length human P5CDh cDNAs, differing in length by 1 kilobase pair (kb). (nih.gov)
Superfamily2
- Sophos NA, Vasiliou V. Aldehyde dehydrogenase gene superfamily: the 2002 update. (medlineplus.gov)
- Although Put2p exhibits the expected aldehyde dehydrogenase superfamily fold, a large portion of the active site is disordered in the crystal structure. (proteopedia.org)
Gene2
- The theory that operons are the remnants of tandem duplication has recently been criticized by Lawrence and Roth [ 5 ], who instead proposed that horizontal gene transfer may be the underlying mechanism for the occurrence of gene clusters. (biomedcentral.com)
- 5] analyzed the gene expression of twelve transcription factors from two drought tolerant peanut genotypes under drought conditions and identified the expression patterns of drought-inducible transcripts. (scielo.cl)
Pyridoxine1
- These vitB6 compounds (also called vitamers) are pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL) and their 5′-phosphorylated forms pyridoxine 5′-phosphate (PNP), pyridoxamine 5′-phosphate (PMP) and pyridoxal 5′-phosphate (PLP). (intechopen.com)
Succinate semialdehyde1
- Comment: GABA (4-aminobutanoate) is consumed by an aminotransferase (known as gabT or puuE), which forms succinate semialdehyde, and dehydrogenase gabD, which forms succinate. (lbl.gov)
Pathway2
Vulgaris1
- betaine aldehyd dehydrogenase [Beta vulgaris subsp. (cornell.edu)
Mutations1
- In a screen for mutations that activate SKN-1-dependent oxidative stress responses in the muscle of C. elegans 5-7 , we identified 96 independent genetic mutants harboring loss-of-function alleles of alh - 6 , exclusively. (sciety.org)
Hydrolase2
- ribonucleoside hydrolase 1 [Salmonella e. (virginia.edu)
- Glycine max bifunctional epoxide hydrolase 2-like (LOC100804496), transcript variant 1, mRNA. (go.jp)
Type1
- [1] The most common type is eumelanin, of which there are two types- brown eumelanin and black eumelanin. (knowpia.com)