Phosphates: Inorganic salts of phosphoric acid.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Phosphatidylinositol 4,5-Diphosphate: A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Phosphatidylinositol Phosphates: Phosphatidylinositols in which one or more alcohol group of the inositol has been substituted with a phosphate group.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Atlases as Topic: Collections of illustrative plates, charts, etc., usually with explanatory captions.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Cervical Atlas: The first cervical vertebra.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.beta Catenin: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Th2 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.Th1 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.Health Insurance Portability and Accountability Act: Public Law 104-91 enacted in 1996, was designed to improve the efficiency and effectiveness of the healthcare system, protect health insurance coverage for workers and their families, and to protect individual personal health information.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.Excitatory Amino Acid Antagonists: Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)Startle Reaction: A complex involuntary response to an unexpected strong stimulus usually auditory in nature.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Clozapine: A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.Antipsychotic Agents: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
(1/398) A plant 126-kDa phosphatidylinositol 4-kinase with a novel repeat structure. Cloning and functional expression in baculovirus-infected insect cells.

Phosphatidylinositol metabolism plays a central role in signaling pathways in animals and is also believed to be of importance in signal transduction in higher plants. We report here the molecular cloning of a cDNA encoding a previously unidentified 126-kDa phosphatidylinositol (PI) 4-kinase (AtPI4Kbeta) from the higher plant Arabidopsis thaliana. The novel protein possesses the conserved domains present in animal and yeast PI 4-kinases, namely a lipid kinase unique domain and a catalytic domain. An additional domain, approximately 300 amino acids long, containing a high percentage (46%) of charged amino acids is specific to this plant enzyme. Recombinant AtPI4Kbeta expressed in baculovirus-infected insect (Spodoptera frugiperda) cells phosphorylated phosphatidylinositol exclusively at the D4 position of the inositol ring. Recombinant protein was maximally activated by 0.6% Triton X-100 but was inhibited by adenosine with an IC50 of approximately 200 microM. Wortmannin at a concentration of 10 microM inhibited AtPI4Kbeta activity by approximately 90%. AtPI4Kbeta transcript levels were similar in all tissues analyzed. Light or treatment with hormones or salts did not change AtPI4Kbeta transcript levels to a great extent, indicating constitutive expression of the AtPI4Kbeta gene.  (+info)

(2/398) Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230.

By constructing DNA probes we have identified and cloned a human PtdIns 4-kinase, PI4K230, corresponding to a mRNA of 7.0 kb. The cDNA encodes a protein of 2044 amino acids. The C-terminal part of ca. 260 amino acids represents the catalytic domain which is highly conserved in all recently cloned PtdIns 4-kinases. N-terminal motifs indicate multiple heterologous protein interactions. Human PtdIns 4-kinase PI4K230 expressed in vitro exhibits a specific activity of 58 micromol mg-1min-1. The enzyme expressed in Sf9 cells is essentially not inhibited by adenosine, it shows a high Km for ATP of about 300 microM and it is half-maximally inactivated by approximately 200 nM wortmannin. These data classify this enzyme as type 3 PtdIns 4-kinase. Antibodies raised against the N-terminal part moderately activate and those raised against the C-terminal catalytic domain inhibit the enzymatic activity. The coexistence of two different type 3 PtdIns 4-kinases, PI4K92 and PI4K230, in several human tissues, including brain, suggests that these enzymes are involved in distinct basic cellular functions.  (+info)

(3/398) G-protein-stimulated phospholipase D activity is inhibited by lethal toxin from Clostridium sordellii in HL-60 cells.

Lethal toxin (LT) from Clostridium sordellii has been shown in HeLa cells to glucosylate and inactivate Ras and Rac and, hence, to disorganize the actin cytoskeleton. In the present work, we demonstrate that LT treatment provokes the same effects in HL-60 cells. We show that guanosine 5'-O-(3-thiotriphosphate)-stimulated phospholipase D (PLD) activity is inhibited in a time- and dose-dependent manner after an overnight treatment with LT. A similar dose response to the toxin was found when PLD activity was stimulated by phorbol 12-myristate 13-acetate via the protein kinase C pathway. The toxin effect on actin organization seemed unlikely to account directly for PLD inhibition as cytochalasin D and iota toxin from Clostridium perfringens E disorganize the actin cytoskeleton without modifying PLD activity. However, the enzyme inhibition and actin cytoskeleton disorganization could both be related to a major decrease observed in phosphatidylinositol 4,5-bisphosphate (PtdIns(4, 5)P2). Likely in a relationship with this decrease, recombinant ADP-ribosylation factor, RhoA, Rac, and RalA were not able to reconstitute PLD activity in LT-treated cells permeabilized and depleted of cytosol. Studies of phosphoinositide kinase activities did not allow us to attribute the decrease in PtdIns(4,5)P2 to inactivation of PtdIns4P 5-kinase. LT was also found to provoke a major inhibition in phosphatidylinositol 3-kinase that could not account for the inhibition of PLD activity because wortmannin, at doses that fully inhibit phosphatidylinositol 3-kinase, had no effect on the phospholipase activity. Among the three small G-proteins, Ras, Rac, and RalA, inactivated by LT and involved in PLD regulation, inactivation of Ral proteins appeared to be responsible for PLD inhibition as LT toxin (strain 9048) unable to glucosylate Ral proteins did not modify PLD activity. In HL-60 cells, LT treatment appeared also to modify cytosol components in relationship with PLD inhibition as a cytosol prepared from LT-treated cells was less efficient than one from control HL-60 cells in stimulating PLD activity. Phosphatidylinositol transfer proteins involved in the regulation of polyphosphoinositides and ADP-ribosylation factor, a major cytosolic PLD activator in HL-60 cells, were unchanged, whereas the level of cytosolic protein kinase Calpha was decreased after LT treatment. We conclude that in HL-60 cells, lethal toxin from C. sordellii, in inactivating small G-proteins involved in PLD regulation, provokes major modifications at the membrane and the cytosol levels that participate in the inhibition of PLD activity. Although Ral appeared to play an essential role in PLD activity, we discuss the role of other small G-proteins inactivated by LT in the different modifications observed in HL-60 cells.  (+info)

(4/398) Coupled inositide phosphorylation and phospholipase D activation initiates clathrin-coat assembly on lysosomes.

Adaptors appear to control clathrin-coat assembly by determining the site of lattice polymerization but the nucleating events that target soluble adaptors to an appropriate membrane are poorly understood. Using an in vitro model system that allows AP-2-containing clathrin coats to assemble on lysosomes, we show that adaptor recruitment and coat initiation requires phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) synthesis. PtdIns(4,5)P2 is generated on lysosomes by the sequential action of a lysosome-associated type II phosphatidylinositol 4-kinase and a soluble type I phosphatidylinositol 4-phosphate 5-kinase. Phosphatidic acid, which potently stimulates type I phosphatidylinositol 4-phosphate 5-kinase activity, is generated on the bilayer by a phospholipase D1-like enzyme located on the lysosomal surface. Quenching phosphatidic acid function with primary alcohols prevents the synthesis of PtdIns(4, 5)P2 and blocks coat assembly. Generating phosphatidic acid directly on lysosomes with exogenous bacterial phospholipase D in the absence of ATP still drives adaptor recruitment and limited coat assembly, indicating that PtdIns(4,5)P2 functions, at least in part, to activate the PtdIns(4,5)P2-dependent phospholipase D1. These results provide the first direct evidence for the involvement of anionic phospholipids in clathrin-coat assembly on membranes and define the enzymes responsible for the production of these important lipid mediators.  (+info)

(5/398) Involvement of PITPnm, a mammalian homologue of Drosophila rdgB, in phosphoinositide synthesis on Golgi membranes.

Phosphatidylinositol transfer protein (PITP) is involved in phospholipase C-mediated signaling and membrane trafficking. We previously reported cloning and characterization of a gene encoding for membrane-bound PITP, named PITPnm, that is a mammalian homologue of the Drosophila retinal degeneration B (rdgB) gene (Aikawa, Y., Hara, H., and Watanabe, T. (1997) Biochem. Biophys. Res. Commun. 236, 559-564). Here we report the subcellular localization of PITPnm protein and provide evidence for its involvement in phosphatidylinositol 4-phosphate (PtdIns 4-P) synthesis. PITPnm is an integral membrane protein that largely localized in close association with membranes of Golgi vacuoles and the endoplasmic reticulum (ER). The amino terminus region of PITPnm was exposed to cytoplasmic side. Interaction with various phosphoinositides was observed in the amino terminus region spanning from 196 amino acids to 257 amino acids of PITPnm. At the amino terminus regions of 1-372 amino acids, PITPnm formed a complex with type III PtdIns 4-kinase. The transmembrane and carboxyl-terminal portions (residues 418-1242) functioned to retain the PITPnm in the Golgi vacuole. These results suggest that PITPnm plays a role in phosphoinositide synthesis on the Golgi vacuoles and possibly in the PtdIns signaling pathway in mammalian cells.  (+info)

(6/398) p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring.

Activation of p85/p110-type phosphatidylinositol (PI) kinase has been implicated in various cellular activities. This PI kinase phosphorylates the D-4 position with a similar or higher efficiency than the D-3 position when trichloroacetic acid-treated cell membrane is used as a substrate, although it phosphorylates almost exclusively the D-3 position of the inositol ring in phosphoinositides when purified PI is used as a substrate. Furthermore, the lipid kinase activities of p110 for both the D-3 and D-4 positions were completely abolished by introducing kinase-dead point mutations in their lipid kinase domains (DeltaKinalpha and DeltaKinbeta, respectively). In addition, both PI 3- and PI 4-kinase activities of p110alpha and p110beta immunoprecipitates were similarly inhibited by either wortmannin or LY294002, specific inhibitors of p110. Insulin induced phosphorylation of not only the D-3 position, but also the D-4 position. Indeed, overexpression of p110 in Sf9 or 3T3-L1 cells induced marked phosphorylation of the D-4 position to a level comparable to or much greater than that of D-3, whereas inhibition of endogenous p85/p110-type PI kinase via overexpression of dominant-negative p85alpha (Deltap85alpha) in 3T3-L1 adipocytes abolished insulin-induced synthesis of both. Thus, p85/p110-type PI kinase phosphorylates the D-4 position of phosphoinositides more efficiently than the D-3 position in vivo, and each of the D-3- or D-4-phosphorylated phosphoinositides may transmit signals downstream.  (+info)

(7/398) Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.

Candida albicans, the most prevalent fungal pathogen in humans, is thought to lack a sexual cycle. A set of C. albicans genes has been identified that corresponds to the master sexual cycle regulators a1, alpha1, and alpha2 of the Saccharomyces cerevisiae mating-type (MAT) locus. The C. albicans genes are arranged in a way that suggests that these genes are part of a mating type-like locus that is similar to the mating-type loci of other fungi. In addition to the transcriptional regulators a1, alpha1, and alpha2, the C. albicans mating type-like locus contains several genes not seen in other fungal MAT loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.  (+info)

(8/398) Receptor-mediated signaling pathways: potential targets of modulation by dietary fatty acids.

Extracellular signals are transmitted to intracellular targets through many signal-transduction pathways. Each signaling pathway is composed of a network of interacting signaling molecules that regulate diverse cellular responses. A modulation of the functional activities of these signaling molecules as a result of altered nutritional status could lead to qualitative and quantitative changes in cellular responses to extracellular signals. Growing evidence now suggests that fatty acids can directly and indirectly modulate signaling pathways at multiple levels. Elucidating the mechanism of this modulation could help us to understand how different types of dietary fat modify the risks of many chronic diseases.  (+info)

*  1-phosphatidylinositol 4-kinase
... phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in ... Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, ... "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): ... Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328-37. PMC 1270113 ...
*  1-phosphatidylinositol-4-phosphate 5-kinase
Other names in common use include diphosphoinositide kinase, PIP kinase, phosphatidylinositol 4-phosphate kinase, ... and type I PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol ... Kai M, Salway JG, Hawthorne JN (1968). "The diphosphoinositide kinase of rat brain". Biochem. J. 106 (4): 791-801. PMC 1198582 ... "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192-6. doi:10.1038/36621. PMID ...
*  1-phosphatidylinositol-5-phosphate 4-kinase
This enzyme is also called type II PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ... phosphatidylinositol signaling system, and regulation of actin cytoskeleton. ... In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 2.7.1.149) is an enzyme that catalyzes the chemical reaction ...
*  PI4KA
1994). "Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI ... 2013). "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A ... "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A". PLoS ... Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene. This gene encodes a 1- ...
*  List of MeSH codes (D08)
... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... phosphatidylinositol diacylglycerol-lyase MeSH D08.811.277.352.640.700.700.750 --- phospholipase c gamma MeSH D08.811.277.352. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ... map kinase kinase 2 MeSH D08.811.913.696.620.682.700.565.300 --- map kinase kinase 3 MeSH D08.811.913.696.620.682.700.565.400 ...
*  PIP5K1C
"Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo ... 2007). "Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct ... 2006). "Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis". J. Biol. ... 2002). "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin". Nature. ...
*  PIP5K1B
"Entrez Gene: PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta". Bayot A, Reichman S, Lebon S, Csaba Z, Aubry L, ... 2004). "Identification and characterization of a phosphoinositide phosphate kinase homolog". J. Biol. Chem. 279 (12): 11672-9. ... Phosphatidylinositol-4-phosphate 5-kinase type-1 beta is an enzyme that in humans is encoded by the PIP5K1B gene. Abnormal ... Loijens JC, Anderson RA (1997). "Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid ...
*  PIP5K1A
2003). "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling". J ... Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene. GRCh38: ... "Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha". Honda A, Nogami M, Yokozeki T, et al. (1999). " ... 2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible ...
*  PI4K2B
Phosphatidylinositol 4-kinase type 2-beta is an enzyme that in humans is encoded by the PI4K2B gene. GRCm38: Ensembl release 89 ... "Entrez Gene: PI4K2B phosphatidylinositol 4-kinase type 2 beta". Griffioen M, van der Meijden ED, Slager EH, et al. (2008). " ... 2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the ... Srivastava R, Sinha RK, Subrahmanyam G (2006). "Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain ...
*  Tumor necrosis factor receptor 1
Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor ... "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4- ... phosphate 5-kinase". J. Biol. Chem. 272 (9): 5861-70. doi:10.1074/jbc.272.9.5861. PMID 9038203. Boldin MP, Mett IL, Wallach D ( ... 367 (1): 39-44. doi:10.1016/0014-5793(95)00534-G. PMID 7601280. Dunbar JD, Song HY, Guo D, Wu LW, Donner DB (1997). "Two-hybrid ...
*  PI4K2A
... kinase domain can be divided into N-terminal and C-terminal lobes with the ATP binding groove and putative phosphatidylinositol ... Phosphatidylinositol 4-kinase 2-alpha is an enzyme that in humans is encoded by the PI4K2A gene. This gene encodes a ... "Entrez Gene: PI4KII phosphatidylinositol 4-kinase type II". Balla, A; Tuymetova, G; Barshishat, M; Geiszt, M; Balla, T (31 May ... PI4K2A is composed of a proline-rich N-terminal region and a kinase domain located C-terminally. The proline-rich N-terminal ...
*  Centaurin, alpha 1
"Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases". The ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... Protein kinase D1, and Protein kinase Mζ. Model organisms have been used in the study of ADAP1 function. A conditional knockout ...
*  TLN2
Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA (Nov 2002). "Type I gamma phosphatidylinositol phosphate kinase ... coordinating phosphatidylinositol synthesis, and modulating actin dynamics through interactions with PIP kinase type 1γ, the ... "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin". Nature. 420 ( ... Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL (Jul 1995). "Interaction of focal adhesion kinase with ...
*  Phosphatidylinositol 5-phosphate
Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines. ... Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci U S A. 2007 ... Phosphatidylinositol 5-phosphate is one of the 7 known cellular phosphoinositides with less understood functions. It is ... In T-cells, two "downstream of tyrosine kinase" proteins DOK1 and DOK2 are proposed as PtdIns5P-binding proteins and effectors ...
*  Neuronal calcium sensor-1
It is the Ca2+-sensing subunit of the yeast phosphatidylinositol (PtdIns)-4-OH kinase, PIK1 It binds to many proteins, some in ... G-protein-coupled receptor kinase 2) D2 dopamine receptor IL1RAPL1 (interleukin-1 receptor accessory protein-like 1 protein) ... type III phosphatidylinositol 4-kinase β) IP3 receptor (this activity is inhibited by lithium - a drug used for the treatment ... 30 (1): 241-8. doi:10.1016/S0896-6273(01)00276-8. PMID 11343658. Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, Liu F ...
*  Casein kinase 1, alpha 1
"Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding ... Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. Casein kinase 1, alpha 1 has been ... Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin ... Casein kinase 1 GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000024576 ...
*  BECN1
Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T (Apr 2001). "Beclin-phosphatidylinositol 3-kinase complex functions at the trans- ... Zeng X, Overmeyer JH, Maltese WA (Jan 2006). "Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in ... "Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1". The Journal of ... Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy- ...
*  PI4KB
"Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene". DNA Research. 4 (4): 301-5. doi ... "Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the ... The kinase domain can be divided into N-terminal and C-terminal lobes with the ATP binding groove and putative ... Phosphatidylinositol 4-kinase beta is an enzyme that in humans is encoded by the PI4KB gene. This gene encodes a ...
*  PIK3R2
"Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". The Journal of ... Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene. PIK3R2 has ... August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology ... a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene. 7 (4): 789-93. PMID 1314371. "Entrez Gene: ...
*  CD7
Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: ... "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8 ... Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 ... 24 (1): 31-52. doi:10.1385/IR:24:1:31. PMID 11485208. Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM ( ...
*  PIK3C2B
"The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25 ... Cook JA, August A, Henderson AJ (Jul 2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by ... The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling ... The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this ...
*  PIK3C3
3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. ... Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme that in humans is encoded by the PIK3C3 gene. GRCh38: ... Vogel LB, Fujita DJ (1994). "The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T ... Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a ...
*  PIK3C2G
Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a ... François F, Klotman ME (2003). "Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication ... The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling ... production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP ...
*  P110δ
Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a ... 1997). "p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed ... François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication ... 1999). "Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro ...
*  Inositol-tetrakisphosphate 5-kinase
This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system. Shears SB (1989). "The ... In enzymology, an inositol-tetrakisphosphate 5-kinase (EC 2.7.1.140) is an enzyme that catalyzes the chemical reaction ATP + 1D ... This enzyme is also called 1D-myo-inositol-tetrakisphosphate 5-kinase. ... 6-tetrakisphosphate 5-kinase". J. Biol. Chem. 264 (33): 19879-86. PMID 2584198. Stevenson-Paulik J, Odom AR, York JD (2002). " ...
*  Interferon
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is also regulated by both type I and type II IFNs. PI3K activates ... Type I IFNs further activate p38 mitogen-activated protein kinase (MAP kinase) to induce gene transcription. Antiviral and ... Production of protein kinase R, for example, can be disrupted in cells infected with JEV Some viruses escape the anti-viral ... In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). This enzyme phosphorylates ...
1-phosphatidylinositol 4-kinase - Wikipedia  1-phosphatidylinositol 4-kinase - Wikipedia
... phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in ... Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, ... "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate". Nature. 332 (6165): ... Kai M, White GL, Hawthorne JN (1966). "The phosphatidylinositol kinase of rat brain". Biochem. J. 101 (2): 328-37. PMC 1270113 ...
more infohttps://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase
1-phosphatidylinositol-4-phosphate 5-kinase - Wikipedia  1-phosphatidylinositol-4-phosphate 5-kinase - Wikipedia
Other names in common use include diphosphoinositide kinase, PIP kinase, phosphatidylinositol 4-phosphate kinase, ... and type I PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol ... Kai M, Salway JG, Hawthorne JN (1968). "The diphosphoinositide kinase of rat brain". Biochem. J. 106 (4): 791-801. PMC 1198582 ... "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature. 390 (6656): 192-6. doi:10.1038/36621. PMID ...
more infohttps://en.wikipedia.org/wiki/1-phosphatidylinositol-4-phosphate_5-kinase
PI4KAP1 (phosphatidylinositol 4-kinase alpha pseudogene 1)  PI4KAP1 (phosphatidylinositol 4-kinase alpha pseudogene 1)
... phosphatidylinositol 4-kinase alpha pseudogene 1), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol. ... X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA PI4KAP1 (phosphatidylinositol 4-kinase alpha pseudogene 1). ... 1-phosphatidylinositol 4-kinase activity intracellular plasma membrane phosphatidylinositol phosphorylation ... phosphatidylinositol-mediated signaling Ontology : EGO-EBI. 1-phosphatidylinositol 4-kinase activity intracellular plasma ...
more infohttp://atlasgeneticsoncology.org/Genes/GC_PI4KAP1.html
RCSB PDB - Protein Feature View 









 - Phosphatidylinositol 4-phosphate 5-kinase type-1 beta - O14986 (PI51B HUMAN)  RCSB PDB - Protein Feature View - Phosphatidylinositol 4-phosphate 5-kinase type-1 beta - O14986 (PI51B HUMAN)
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin ... 1,2-diacyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = a 1,2-diacyl-sn-glycero-3-phospho-1D-myo-inositol-4,5- ...
more infohttp://www.rcsb.org/pdb/protein/O14986
Pip5k1c - Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma - Mus musculus (Mouse) - Pip5k1c gene & protein  Pip5k1c - Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma - Mus musculus (Mouse) - Pip5k1c gene & protein
... to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and ... P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a ... Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in ... is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of ...
more infohttps://www.uniprot.org/uniprot/O70161
1-phosphatidylinositol-4-phosphate 5-kinase - wikidoc  1-phosphatidylinositol-4-phosphate 5-kinase - wikidoc
Other names in common use include diphosphoinositide kinase, PIP kinase, phosphatidylinositol 4-phosphate kinase, ... and type I PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol ... Kai M, Salway JG, Hawthorne JN (1968). "The diphosphoinositide kinase of rat brain". Biochem. J. 106: 791-801. PMID 4295336.. ... Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". ...
more infohttp://es.wikidoc.org/index.php/1-phosphatidylinositol-4-phosphate_5-kinase
SPHINX - Pathway - 1-phosphatidylinositol-3-phosphate 4-kinase activity  SPHINX - Pathway - 1-phosphatidylinositol-3-phosphate 4-kinase activity
1) year after it arises, except to the extent such limitation is not enforceable. To the fullest extent permitted by law, each ...
more infohttps://www.emergesphinx.org/pathways/1-phosphatidylinositol-3-phosphate-4-kinase-activity
Pip5k1b (untagged) - Mouse phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (cDNA clone MGC:41200 IMAGE:3326897), (10ug) ...  Pip5k1b (untagged) - Mouse phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (cDNA clone MGC:41200 IMAGE:3326897), (10ug) ...
Mouse phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (cDNA clone MGC:41200 IMAGE:3326897), (10ug), 10 µg. ... Home » cDNA » Mouse cDNA » Pip5k1b (untagged) - Mouse phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (cDNA clone MGC: ... Properties for Pip5k1b (untagged) - Mouse phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (cDNA clone MGC:41200 IMAGE: ... MC217732 Pip5k1b (untagged) - Mouse phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (cDNA clone MGC:41200 IMAGE:3326897 ...
more infohttps://www.acris-antibodies.com/cdna/mouse-cdna/pip5k1b-untagged-mouse-phosphatidylinositol-4-phosphate-5-kinase-type-1-beta-cdna-clone-mgc-41200-image-3326897-10ug-mc217732.htm
KEGG ENZYME: 2.7.1.67  KEGG ENZYME: 2.7.1.67
phosphatidylinositol kinase (phosphorylating);. phosphatidylinositol 4-kinase;. phosphatidylinositol kinase;. type II ... Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. ... A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans. ... Pathway (7) KEGG PATHWAY (6) KEGG MODULE (1) Chemical substance (4) KEGG COMPOUND (4) Chemical reaction (3) KEGG REACTION (1) ...
more infohttps://www.genome.jp/dbget-bin/www_bget?enzyme+2.7.1.67
PI4KAP2 Gene - GeneCards | PI4KAP2 Pseudogene  PI4KAP2 Gene - GeneCards | PI4KAP2 Pseudogene
Phosphatidylinositol 4-Kinase Alpha Pseudogene 2, including: function, proteins, disorders, pathways, orthologs, and expression ... Putative phosphatidylinositol 4-kinase alpha-like protein P2. Protein Accession:. A4QPH2. Secondary Accessions: *Q6ICJ0 ... Gene Ontology (GO) annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as ... Phosphatidylinositol 4-Kinase, Catalytic, Alpha Pseudogene 2 2 3 * Phosphatidylinositol 4-Kinase, Catalytic, Alpha Polypeptide ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=PI4KAP2
Differential Timing of Spider Mite-Induced Direct and Indirect Defenses in Tomato Plants | Plant Physiology  Differential Timing of Spider Mite-Induced Direct and Indirect Defenses in Tomato Plants | Plant Physiology
Diacylglycerol kinase. ST. 2.6. 0.015. 1.6. 0.093. Le. TC125973. 3-Phosphatidylinositol 5-kinase, FAB1. ST. 2.3. 0.029. 1.6. ... Leu rich repeat containing protein kinase. ST. 2.1. 0.047. 1.8. 0.087. Le. TC122585. Phosphoinositide-specific phospholipase Dβ ... diacylglycerol kinase (DGK; BE434771), or polyubiquitin (UBQ) as loading control. The ethidium bromide-stained gel (EtBr) is ... 1-Phosphatidylinositol 4-kinase. ST. 3.1. 0.068. 2.7. 0.018. Le. TC120983. Protein phosphatase type 2C. ST. 3.1. 0.038. 3.9. ...
more infohttp://www.plantphysiol.org/content/135/1/483/tab-figures-data
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1  Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs ( ... HCA RNA Cell Line for Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. ... P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and ... May act as a scaffold to localize and regulate type I PI(4) ... Brain - Spinal cord (cervical c-1) 17,973 Colon - Transverse ...
more infohttps://pharos.nih.gov/idg/targets/Q5T9C9
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1  Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs ( ... HCA RNA Cell Line for Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. ... P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and ... May act as a scaffold to localize and regulate type I PI(4) ... Brain - Spinal cord (cervical c-1) 17,973 Colon - Transverse ...
more infohttps://pharos.nih.gov/idg/targets/PIP5KL1
Gene Info  Gene Info
BP] phosphatidylinositol biosynthetic process *[BP] phosphatidylinositol phosphorylation *[BP] phosphatidylinositol-mediated ... MF] kinase activity *[MF] nucleotide binding *[MF] phosphotransferase activity, alcohol group as acceptor *[MF] transferase ... phosphatidylinositol 4-kinase, catalytic, beta polypeptide. 8861477. Full Length. BC138457. phosphatidylinositol 4-kinase, ... phosphatidylinositol 4-kinase, catalytic, beta polypeptide. 40060770. Full Length. BC113781. phosphatidylinositol 4-kinase, ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=217222&LLNO=107650
PIK1 | SGD  PIK1 | SGD
Phosphatidyl Inositol Kinase 1 Comparative Info. Integrated model organism details available at the Alliance of Genome ... Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control ... Essential gene; conditional mutations disturb phosphatidylinositol phosphate pools and cause multiple abnormalities in actin ... PIK1 1 Systematic Name. YNL267W. SGD ID. SGD:S000005211. Aliases. PIK41 28 , PIK120 28 Feature Type. ORF , Verified Description ...
more infohttps://www.yeastgenome.org/locus/PIK1
ELISA test for Phosphatidylinositol-4-phosphate 5-kinase -1 gamma (PIP5K1C) | Technique alternative | 01011393927 -...  ELISA test for Phosphatidylinositol-4-phosphate 5-kinase -1 gamma (PIP5K1C) | Technique alternative | 01011393927 -...
... phosphate 5-kinase type-1 gamma PIP5K1C 01011393927 at Gentaur for Phosphatidylinositol-4-phosphate 5-kinase 1 gamma (PIP5K1C) ... Human Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C) ELISA Kit is manufactured by highest quality antibodies ... Store and ship all of of the comptents of the EIA assay for Human Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma ( ... ELISA test for Human Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIP5K1C). * ...
more infohttps://phosphatidylinositol.com/products/24-abebio/211-elisa-test-for-human-phosphatidylinositol-4-phosphate-5-kinase-type-1-gamma-pip5k1c
Pi4kb - Phosphatidylinositol 4-kinase beta - Mus musculus (Mouse) - Pi4kb gene & protein  Pi4kb - Phosphatidylinositol 4-kinase beta - Mus musculus (Mouse) - Pi4kb gene & protein
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- ... Phosphatidylinositol 4-kinase betaAdd BLAST. 815. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... kinase_CS. IPR015433 PI_Kinase. IPR001263 PInositide-3_kin_accessory_dom. ... kinase_CS. IPR015433 PI_Kinase. IPR001263 PInositide-3_kin_accessory_dom. ...
more infohttps://www.uniprot.org/uniprot/Q8BKC8
Gene Info  Gene Info
BP] phosphatidylinositol biosynthetic process *[BP] phosphatidylinositol metabolic process *[BP] positive regulation of 1- ... phosphatidylinositol 4-kinase activity *[BP] positive regulation of cell proliferation *[BP] positive regulation of peptidyl- ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=54457&LLNO=975
Tissue expression of PI4K2B - Summary - The Human Protein Atlas  Tissue expression of PI4K2B - Summary - The Human Protein Atlas
GO:0016301 [kinase activity]. GO:0016310 [phosphorylation]. GO:0016740 [transferase activity]. GO:0046854 [phosphatidylinositol ... Phosphatidylinositol 4-kinase type 2 beta (HGNC Symbol). Entrez gene summary. This gene encodes a member of the type II PI4 ... Phosphatidylinositol 4-kinase type 2 beta. Protein classi. Protein class the gene product belongs to according to selected gene ... GO:0006661 [phosphatidylinositol biosynthetic process]. GO:0007030 [Golgi organization]. GO:0007032 [endosome organization]. GO ...
more infohttp://www.proteinatlas.org/ENSG00000038210-PI4K2B/tissue
Characterization of FOXO1,3 and 4 transcription factors in ovaries of fetal, prepubertal and adult rhesus macaques<...  Characterization of FOXO1,3 and 4 transcription factors in ovaries of fetal, prepubertal and adult rhesus macaques<...
The phosphoinositide 3-kinase/AKT (protein kinase B) signaling pathway negatively regulates follicle activation via the ... N2 - The phosphoinositide 3-kinase/AKT (protein kinase B) signaling pathway negatively regulates follicle activation via the ... AB - The phosphoinositide 3-kinase/AKT (protein kinase B) signaling pathway negatively regulates follicle activation via the ... abstract = "The phosphoinositide 3-kinase/AKT (protein kinase B) signaling pathway negatively regulates follicle activation via ...
more infohttps://ohsu.pure.elsevier.com/en/publications/characterization-of-foxo13-and-4-transcription-factors-in-ovaries
  • Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications. (wikipedia.org)
  • Ablation of both talin isoforms, talin-2 and talin-1 prevented normal myoblast fusion and sarcomere assembly, as well as assembly of integrin adhesion complexes, which was attributed to disrupted interactions between integrins and the actin cytoskeleton. (wikipedia.org)
  • This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of the actin cytoskeleton. (wikipedia.org)
  • Talin-2, like talin-1 appears to join ligand-bound integrins and the actin cytoskeleton, which enhances the affinity of integrins for the extracellular matrix and catalyzes focal adhesion-dependent signaling pathways, as well as reinforces the cytoskeletal-integrin structure in response to an applied force. (wikipedia.org)
  • PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. (wikipedia.org)
  • Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. (wikipedia.org)
  • NCS-1 is a member of the neuronal calcium sensor family, a class of EF hand containing calcium-myristoyl-switch proteins. (wikipedia.org)
  • Gene Ontology (GO) annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as acceptor . (genecards.org)
  • Increased kinase activity upon interaction with NCS1/FREQ. (uniprot.org)
  • The proline-rich N-terminal region contains physiologically important binding sites for a ubiquitin ligase Itch and clathrin adaptor complex 3, but is likely disordered and dispensable for the kinase activity. (wikipedia.org)
  • The N-terminal region contains a physiologically important binding site for a Golgi adaptor protein ACBD3, but is likely disordered and dispensable for the kinase activity. (wikipedia.org)
  • The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. (wikipedia.org)
  • May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. (nih.gov)
  • Besides the fact, that PI4P serves as a precursor for other important phosphoinositides, such as phosphatidylinositol 4,5-bisphosphate, PI4P is an essential molecule in the cellular signaling and trafficking especially in the Golgi apparatus and the trans Golgi network. (wikipedia.org)
  • See also: Category:Genes on human chromosome 4. (wikipedia.org)
  • The following is a partial list of genes on human chromosome 4. (wikipedia.org)
  • Work in bovine chromaffin cells demonstrated that NCS-1 is also a modulator of neurotransmission in mammals. (wikipedia.org)
  • Chromosome 9 spans about 138 million base pairs of nucleic acids (the building blocks of DNA) and represents between 4 and 4.5 percent of the total DNA in cells. (wikipedia.org)
  • Chromosome 4 spans more than 186 million base pairs (the building material of DNA) and represents between 6 and 6.5 percent of the total DNA in cells. (wikipedia.org)
  • 1996). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. (wikipedia.org)