1-Octanol: A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Octanols: Isomeric forms and derivatives of octanol (C8H17OH).Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)Octanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.Hexanols: Isomeric forms and derivatives of hexanol (C6H11OH).Heptanol: A colorless liquid with a fragrant odor. It is used as an intermediate, solvent and in cosmetics.2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.Anesthetics: Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.Gap Junctions: Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.Glycyrrhetinic Acid: An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.Pentanols: Isomeric forms and derivatives of pentanol (C5H11OH).Liquid Phase Microextraction: Miniaturized methods of liquid-liquid extraction.Carbenoxolone: An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Multiple Chemical Sensitivity: An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)United States Government Agencies: Agencies of the FEDERAL GOVERNMENT of the United States.Nisin: A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.Judgment: The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.Xylella: A genus of gram-negative, aerobic bacteria, in the family XANTHOMONADACEAE. It is found in the xylem of plant tissue.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Vitis: A plant genus in the family VITACEAE, order Rhamnales, subclass Rosidae. It is a woody vine cultivated worldwide. It is best known for grapes, the edible fruit and used to make WINE and raisins.Rhizomucor: A genus of zygomycetous fungi of the family Mucoraceae, order MUCORALES.Ionic Liquids: Salts that melt below 100 C. Their low VOLATILIZATION can be an advantage over volatile organic solvents.Mucorales: An order of zygomycetous fungi, usually saprophytic, causing damage to food in storage, but which may cause respiratory infection or MUCORMYCOSIS in persons suffering from other debilitating diseases.Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.Hydrolases: Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.Essential Tremor: A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.Mentha: Mentha is a genus of the mint family (LAMIACEAE). It is known for species having characteristic flavor and aroma.Coriandrum: A plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.Telefacsimile: A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.Social Media: Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.Social Networking: Individuals connecting by family, work or other interests. It also includes connectivity facilitated by computer-based communications.Blogging: Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Fatty Alcohols: Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Alcoholic Beverages: Drinkable liquids containing ETHANOL.Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Waxes: A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Sjogren-Larsson Syndrome: An autosomal recessive neurocutaneous disorder characterized by severe ichthyosis MENTAL RETARDATION; SPASTIC PARAPLEGIA; and congenital ICHTHYOSIS. It is caused by mutation of gene encoding microsomal fatty ALDEHYDE DEHYDROGENASE leading to defect in fatty alcohol metabolism.Phytophthora: A genus of destructive parasitic OOMYCETES in the family Peronosporaceae, order Peronosporales, affecting numerous fruit, vegetable, and other crops. Differentiation of zoospores usually takes place in the sporangium and no vesicle is formed. It was previously considered a fungus.Fungicides, Industrial: Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Phytophthora infestans: A species of parasitic OOMYCETES in the family Peronosporaceae that is the causative agent of late blight of potato.Pythium: A genus of destructive root-parasitic OOMYCETES in the family Pythiaceae, order Peronosporales, commonly found in cultivated soils all over the world. Differentiation of zoospores takes place in a vesicle.Cucumis melo: A plant species of the family CUCURBITACEAE, order Violales, subclass Dilleniidae known for the melon fruits with reticulated (net) surface including cantaloupes, honeydew, casaba, and Persian melons.

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries. (1/84)

Previous studies show that linking acetylated glucosamine to S-nitroso-N-acetyl-D,L-penicillamine (SNAP) stabilizes the molecule and causes it to elicit unusually prolonged vasodilator effects in endothelium-denuded, isolated rat femoral arteries. Here we studied the propanoyl (SNPP; 3 carbon side-chain), valeryl (SNVP; 5C) and heptanoyl (SNHP; 7C) N-substituted analogues of SNAP (2C), to further investigate other molecular characteristics that might influence chemical stability and duration of vascular action of S-nitrosothiols. Spectrophotometric analysis revealed that SNVP was the most stable analogue in solution. Decomposition of all four compounds was accelerated by Cu(II) and cysteine, and neocuproine, a specific Cu(I) chelator, slowed decomposition of SNHP. Generation of NO from the compounds was confirmed by electrochemical detection at 37 degrees C. Bolus injections of SNAP (10 microl; 10(-8)-10(-3) M) into the perfusate of precontracted, isolated rat femoral arteries taken from adult male Wistar rats (400-500 g), caused concentration-dependent, transient vasodilatations irrespective of endothelial integrity. Equivalent vasodilatations induced by SNVP and SNHP were transient in endothelium-intact vessels but failed to recover to pre-injection pressures at moderate and high concentrations (10(-6)-10(-3) M) in those denuded of endothelium. This sustained effect (> 1 h) was most prevalent with SNHP and was largely reversed by the NO scavenger, haemoglobin. We suggest that increased lipophilicity of SNAP analogues with longer sidechains facilitates their retention by endothelium-denuded vessels; subsequent slow decomposition within the tissue generates sufficient NO to cause prolonged vasodilatation. This is a potentially useful characteristic for targeting NO delivery to areas of endothelial damage.  (+info)

A solvent model for simulations of peptides in bilayers. I. Membrane-promoting alpha-helix formation. (2/84)

We describe an efficient solvation model for proteins. In this model atomic solvation parameters imitating the hydrocarbon core of a membrane, water, and weak polar solvent (octanol) were developed. An optimal number of solvation parameters was chosen based on analysis of atomic hydrophobicities and fitting experimental free energies of gas-cyclohexane, gas-water, and octanol-water transfer for amino acids. The solvation energy term incorporated into the ECEPP/2 potential energy function was tested in Monte Carlo simulations of a number of small peptides with known energies of bilayer-water and octanol-water transfer. The calculated properties were shown to agree reasonably well with the experimental data. Furthermore, the solvation model was used to assess membrane-promoting alpha-helix formation. To accomplish this, all-atom models of 20-residue homopolypeptides-poly-Leu, poly-Val, poly-Ile, and poly-Gly in initial random coil conformation-were subjected to nonrestrained Monte Carlo conformational search in vacuo and with the solvation terms mimicking the water and hydrophobic parts of the bilayer. All the peptides demonstrated their largest helix-forming tendencies in a nonpolar environment, where the lowest-energy conformers of poly-Leu, Val, Ile revealed 100, 95, and 80% of alpha-helical content, respectively. Energetic and conformational properties of Gly in all environments were shown to be different from those observed for residues with hydrophobic side chains. Applications of the solvation model to simulations of peptides and proteins in the presence of membrane, along with limitations of the approach, are discussed.  (+info)

Agonist and potentiation actions of n-octanol on gamma-aminobutyric acid type A receptors. (3/84)

The n-octanol effects on the gamma-aminobutyric acid type A (GABAA) receptor were studied in human embryonic kidney 293 cells transfected with alpha1, beta2, and gamma2S subunit cDNAs. GABA-evoked currents had an EC50 of 13.3 +/- 1.7 microM and a Hill coefficient (nH) of 1.4 +/- 0.1. n-Octanol was also capable of evoking a small current with an EC50 of 1000 microM and an nH of 2. In addition, n-octanol modulated GABA-induced currents in a concentration-dependent manner. Coapplications of n-octanol increased peak currents evoked by 3 microM GABA with an EC50 of 190 microM and an nH of 1.8. The extent of potentiation decreased with increasing GABA concentrations and no potentiation was observed when n-octanol was coapplied with 1000 microM GABA. One-minute preapplication of 1000 microM n-octanol slightly potentiated 3 microM GABA-induced current, whereas it suppressed 300 microM GABA-induced current to 16% of the control, suggesting that 84% of the receptors underwent desensitization. Two models were used to explain n-octanol agonistic and potentiating actions on the alpha1beta2gamma2S GABAA receptor: n-octanol binds to multiple sites to exert multiple actions, or n-octanol acts as a partial agonist to manifest these actions. The partial agonist model is unique because it is a simpler model to explain n-octanol actions on the GABAA receptor.  (+info)

Functional gap junctions in the early sea urchin embryo are localized to the vegetal pole. (4/84)

Using the whole-cell voltage-clamp technique we have studied electrical coupling and dye coupling between pairs of blastomeres in 16- to 128-cell-stage sea urchin embryos. Electrical coupling was established between macromeres and micromeres at the 16-cell stage with a junctional conductance (G(j)) of 26 nS that decreased to 12 nS before the next cleavage division. G(j) between descendants of macromeres and micromeres was 12 nS falling to 8 nS in the latter half of the cell cycle. Intercellular current intensity was independent of transjunctional voltage, nondirectional, and sensitive to 1-octanol and therefore appears to be gated through gap junction channels. There was no significant coupling between other pairs of blastomeres. Lucifer yellow did not spread between these electrically coupled cell pairs and in fact significant dye coupling between nonsister cells was observed only at the 128-cell stage. Since 1-octanol inhibited electrical communication between blastomeres at the 16- to 64-cell stage and also induced defects in formation of the archenteron, it is possible that gap junctions play a role in embryonic induction.  (+info)

Quantitative trait loci influencing honeybee alarm pheromone levels. (5/84)

Quantitative trait loci (QTL) mapping procedures were used to identify loci that influence the levels of alarm pheromones found in the stinging apparatus of worker honeybees. An F1 queen was produced from a cross between a queen of European origin and a drone descended from an African subspecies. Haploid drones from the hybrid queen were individually backcrossed to European queens to produce 172 colonies. Samples of stings were taken from backcross workers of these colonies. Alarm pheromone levels were determined by gas chromatography. RAPD markers were scored from the haploid drone fathers of these colonies. The multiple-QTL model (MQM) of MapQTL was used to identify QTLs that influence the levels of four alarm pheromone components. Seven independent, potential QTLs were identified with LOD scores greater than two, and one at LOD 1.88. We identified one QTL for n-decyl acetate, three for n-octanol, four for isopentyl acetate, and one for hexyl acetate. One region of linkage group XI shows a strong influence on body size and the levels of three alarm pheromone components. This locus explained 40% of the variance for the amount of n-decyl acetate (LOD 6.57). In general, the QTLs influencing alarm pheromone levels were independent of previously identified loci that influenced the stinging behavior of these colonies. The only exception was a potential locus influencing levels of n-octanol, which was inversely correlated with stinging behavior.  (+info)

A cell type-specific and gap junction-independent mechanism for the herpes simplex virus-1 thymidine kinase gene/ganciclovir-mediated bystander effect. (6/84)

Tumor cells expressing the herpes simplex virus type 1 thymidine kinase (HSV-tk) gene are killed by nucleoside analogues such as ganciclovir (GCV). GCV affects not only the cells expressing HSV-tk but also neighboring cells that do not express the gene; this phenomenon commonly is called "bystander effect." GCV metabolites transfer via gap junctional intercellular communication (GJIC) accounts for the bystander effect in different cell lines, but other mechanisms have also been described. In this study, we analyzed the mechanisms of the bystander effect in two cell lines exhibiting different capacities of communication (DHD/K12 and 9L). The 9L cells exhibited a very good bystander effect, which was completely blocked by a long-term inhibitor of GJIC, 18 alpha-glycyrrhetinic acid. DHD/K12 cells exhibited a moderate bystander effect that was not abolished by 18 alpha-glycyrrhetinic acid or 1-octanol, another strong inhibitor of GJIC. Interestingly, we also observed a bystander effect in cultures where HSV-tk-expressing DHD/K12 cells were physically separated from their untransfected counterparts but grown in the same medium. Moreover, the transfer of filtered conditioned medium from GCV-treated HSV-tk-expressing DHD/K12 cells to DHD/K12 parental cells induced a decrease of survival in a concentration-dependent manner, suggesting that the bystander effect in this cell line was mediated by a soluble factor.  (+info)

Blocking and the detection of odor components in blends. (7/84)

Recent studies of olfactory blocking have revealed that binary odorant mixtures are not always processed as though they give rise to mixture-unique configural properties. When animals are conditioned to one odorant (A) and then conditioned to a mixture of that odorant with a second (X), the ability to learn or express the association of X with reinforcement appears to be reduced relative to animals that were not preconditioned to A. A recent model of odor-based response patterns in the insect antennal lobe predicts that the strength of the blocking effect will be related to the perceptual similarity between the two odorants, i.e. greater similarity should increase the blocking effect. Here, we test that model in the honeybee Apis mellifera by first establishing a generalization matrix for three odorants and then testing for blocking between all possible combinations of them. We confirm earlier findings demonstrating the occurrence of the blocking effect in olfactory learning of compound stimuli. We show that the occurrence and the strength of the blocking effect depend on the odorants used in the experiment. In addition, we find very good agreement between our results and the model, and less agreement between our results and an alternative model recently proposed to explain the effect.  (+info)

Effects of insulin-like growth factor-I on in vitro final oocyte maturation and ovarian steroidogenesis in striped bass, Morone saxatilis. (8/84)

Recombinant human (rh) insulin-like growth factor-I (IGF-I) was more potent than rhIGF-II at inducing in vitro germinal vesicle breakdown (GVBD), a marker for resumption of meiosis, in oocytes of striped bass. Treatment of ovarian fragments containing oocytes in intact follicles with rhIGF-I increased concentrations of estradiol-17beta and maturation-inducing steroid (MIS) 17,20beta, 21-trihydoxy-4-pregnen-3-one (20beta-S) in the culture medium and decreased testosterone levels. The follicles were too immature for oocytes to complete GVBD in response to 20beta-S (MIS incompetent) or hCG. Addition of 20beta-S to cultures did not increase the percentage of oocytes completing GVBD in response to rhIGF-I or rhIGF-II. Bovine insulin was without effect on GVBD or steroid production. Incubation of MIS-competent follicles with actinomycin D, cyanoketone, trilostane, 1-heptanol, or 1-octanol had no effect on rhIGF-I-induced GVBD, but attenuated hCG-induced GVBD and 20beta-S production. Cycloheximide inhibited rhIGF-I-induced GVBD. Collectively, these observations indicate that IGF-I can induce GVBD via MIS- and transcription-independent pathways without coupled gap junctions between oocytes and granulosa cells or among granulosa cells, but requires protein synthesis to do so. An rhIGF-I analogue that does not bind IGF-binding proteins, des(1,3)IGF-I, was more potent than rhIGF-I in inducing GVBD, suggesting ovarian IGF-binding proteins may inhibit IGF-I action.  (+info)

Objectives The occupational hazard of chemical absorption via dermal route was frequently assessed by evaluating the skin permeability (Kp) of chemical. In addition to in vitro testing using human skin, the quantitative structure-activity relationship (QSAR) has been employed as an alternative source to providing Kp. In the early Kp QSARs the octanol-water partition coefficient (log KOW) and molecular weight (MW) were commonly applied as dominant properties to describe transdermal transport of chemical. This study examined the efficacy of log KOW-/MW-based QSARs in Kp prediction.. ...
Chiral 2-octanol is one of the key intermediates for preparation of liquid crystal materials, as well as many optically active pharmaceuticals. Lipase catalyzed kinetic resolution has proved to be an efficient technique for synthesis of enantiomerically enriched compounds. In the present study, optimization and kinetic modeling of kinetic resolution of (±)-2-octanol was done by using vinyl acetate as an acyl donor in n-heptane as a solvent. Response surface methodology (RSM) and four-factor-five-level Centre Composite Rotatable Design (CCRD) were employed to evaluate the effect of various parameters such as speed of agitation, enzyme loading, temperature and acyl donor/alcohol molar ratio on conversion, enantiomeric excess (ee), enantioselectivity and initial rate of reaction. Acylation of 2-octanol with vinyl acetate catalyzed by Novozyme 435 follows the ternary complex mechanism (ordered bi-bi mechanism) with inhibition by 2-octanol.
Chiral 2-octanol is one of the key intermediates for preparation of liquid crystal materials, as well as many optically active pharmaceuticals. Lipase catalyzed kinetic resolution has proved to be an efficient technique for synthesis of enantiomerically enriched compounds. In the present study, optimization and kinetic modeling of kinetic resolution of (±)-2-octanol was done by using vinyl acetate as an acyl donor in n-heptane as a solvent. Response surface methodology (RSM) and four-factor-five-level Centre Composite Rotatable Design (CCRD) were employed to evaluate the effect of various parameters such as speed of agitation, enzyme loading, temperature and acyl donor/alcohol molar ratio on conversion, enantiomeric excess (ee), enantioselectivity and initial rate of reaction. Acylation of 2-octanol with vinyl acetate catalyzed by Novozyme 435 follows the ternary complex mechanism (ordered bi-bi mechanism) with inhibition by 2-octanol.
VCPL, Hyderabad India offers Octan-1-ol HPLC CAS # 111-87-5. We are best Octanol, Octan-1-ol HPLC, Octyl alcohol, 1-Octanol, Octan-1-ol HPLC manufacturer
An experiment was undertaken by Tanniet al. (1992) to determine the octanol-water partition coefficient of 2-(2-methylpropoxy)ethanol and thirteen other ethylene glycol ethers as part of a study evaluating structure-toxicity relationships. The estimation (solubility ratio) methodology followed was according to that outlined by Tanni and Hashimoto (1982) and involved analyses by gas-liquid chromatography with flame ionisation detection and a glass column. Under the conditions of the experiment, 2-(2-methylpropoxy)ethanol was reported to be evidently separated from the organic (n-octanol) phase that had been dissolved in water. Following analyses, a log Kow of 0.75 was determined for 2-(2-methylpropoxy)ethanol. ...
Transport of metals between aqueous phase and soil/sediment/suspended matter should be described on the basis of measured soil/water, sediment/water and suspended matter/water equilibrium partition coefficients (Kp), instead of using common mathematical relationships based on, for example, octanol-water partition coefficients, as is usually done for organic chemicals (TGD, 1996). Kpsoil Four reliable studies were identified in the EU RAR for diantimony trioxide which report soil Kp. Vangheluwe et al. (2001) report the results of a transformation experiment in soil using Sb2O3and SbCl3. The transformation experiment was performed for a duration of 24 weeks, with soils incubated at 20ºC, with a final humidity of 22g/100g dry substance (both soils). The incubation was initiated with 2 drying/rewetting cycles. Calculation of the Kpsoil, using a control soil in Vangheluwe et al. (2001), results in a partition coefficient in sandy soils of 81 l/kg (log Kpsoil= 1.91) and 150 l/kg (log Kpsoil= 2.18) in ...
This study evaluates the potential application of micellar liquid chromatography (MLC) to predict skin permeation with a series of model compounds. MLC has previously been found to be useful in the prediction of partition coefficient values (logP) for pharmaceutical compounds, yet has not been incorporated in skin permeability models prior to this work. This article provides statistically supported data that this technique enhances the ability to predict the permeability of similar drugs through the skin (Kp). The replacement of a traditional physicochemical parameter, namely the octanol-water partition coefficient (logPow) with a chromatographically determined value (logPmw), results in a quantitative partition-permeability relationship that is robust to variation. MLC offers many benefits compared with the traditional techniques employed to obtain logP values.. ...
Waiver. In accordance with column 2 of REACH Annexes XIII, the adsorption / desorption study (required in section 9.3.1 and 9.3.3) do not need to be conducted if, based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol-water partition coefficient). The partition coefficient of HQEE was determined in a reliable study (Young 2012) where the measured log Kow is 0.41. Therefore, HQEE is considered to have low potential for absorption and no further testing is required. ...
For each SSRI, laboratory environmental fate measurements will include the following: aqueous solubility; octanol-water partition coefficient (Kow); acid dissociation constant (pKa); soil adsorption coefficient (Koc); hydrolysis and aqueous direct photolysis rates at pH 5,7and 9; indirect photolysis rates including the hydroxyl radical rate constant; irradiated and dark aerobic-aquatic metabolism; and ready biodegradability. Major degradation products will be identified wherever possible. The occurrence of each SSRI and major metabolites/degradation products will be measured over one year in raw and treated wastewater, and receiving water at sub-ppb levels. Potential loads to waste treatment facilities will be assessed through surveys of numbers of prescriptions filled by local pharmacies. Acute toxicity and chronic exposure tests for survival and reproduction will be conducted with Ceriodaphnia following EPA protocols on each SSRI as well as on raw sewage water and treated effluent. Toxicity ...
A mathematical model has been developed that is based on the molecular mechanism of diffusion and that explicitly incorporates the non-uniform structure of the stratum corneum. The model is used to predict permeability coefficients of chemicals based on their molecular weight (MW) and octanol-water partition coefficient (P).
A poster (P165) presented at ASMS 2017, Indianapolis, discusses three sample preparation methodologies for 52 drug analytes, and presents evaluations of recovery, matrix effects and process efficiency. While "dilute and shoot" methods are easy and affordable, they can result in shortened LC column lifetimes and increased MS instrumentation downtime. Matrix effects can also effect sensitivity and overall method performance. Supported Liquid extraction (SLE) and Solid Phase Extraction (SPE) provide cleaner samples for LC-MS/MS and more robust clinical assays.. Successful sample preparation method development requires understanding the retention mechanism of the analytes in the assay. The octanol-water partition coefficient (logP) and acid dissociation constant (pKa) of the compounds of interest are important properties that can guide sample preparation strategy and optimization of method conditions.. Conclusions. ...
Crystals of an ion-channel-forming peptaibol peptide in a partial membrane environment have been obtained by cocrystallizing antiamoebin with n-octanol. The antiamoebin molecule has a bent helical conformation very similar to that established for Leu-zervamicin, despite a significantly different sequence for residues 1-8. The bent helices assemble to form a polar channel in the shape of an hour glass that is quite comparable to that of Leu-zervamicin. The molecules of cocrystallized octanol are found in two different areas with respect to the assembly of peptide molecules. One octanol molecule mimics a membrane segment along the hydrophobic exterior of the channel assembly. The other octanol molecules fill the channel in such a way that their OH termini satisfy the C==O moieties directed into the interior of the channel. Structure parameters for C82 H27 N17 O20(.3) C8H18O are space group P2(1) 2(1) 2(1), a = 9.143(2) A, b = 28.590(8) A, c = 44.289(8) A, Z = 4, agreement factor R1 = 11.95% for 4,113
BioAssay record AID 24206 submitted by ChEMBL: Partition coefficient between octanol and pH 7.2 phosphate buffer; NT means Not tested.
Lonsdale, T. H.; Lauterbach, L.; Malca, S. H.; Nestl, B. M.; Hauer, B.; Lenz, O. H2-driven biotransformation of n-octane to 1-octanol by a recombinant Pseudomonas putida strain co-synthesizing an O2-tolerant hydrogenase and a P450 monooxygenase. Chem. Commun. 2015, 51 (90), 16173-16175.. Farmer, T. J.; Clark, J. H.; Gothe, M. L.; Macquarrie, D. J.; Sherwood, J. p-Cymenesulphonyl Chloride: A Bio-Based Activating Group and Protecting Group for Greener Organic Synthesis. J. Braz. Chem. Soc. 2015, 26 (9), 1914-1919.. ...
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Let us now consider the transfer of amino acids from water to a bilayer membrane. According to the calculations of MacCallum et al. (2007), transfer from bulk water to the membrane interior correlates well with the water/cyclohexane scale. In contrast, the transfer of free energy from bulk water to the membrane interface correlates very well with the water/octanol scale. This is the result one would expect a priori. Indeed, it was noted previously that the partitioning of short peptide, designed to occupy the membrane-solution interface, correlates well with the water/octanol scale (Wimley and White, 1996; Wimley et al., 1996). In summary, the water/octanol thermodynamic scale does not reflect the partitioning of amino acids in the interior of membranes but to the membrane-solution interface. Finally, let us consider an even more complex situation, the insertion of transmembrane helices using the translocon expression system. The fascinating measurements of Hessa et al. (2005a) are suggestive of ...
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A determination of the partition coefficient cannot be performed. The TNb-results determined are only slightly above the LOQ. As the test item and the hydrolysis products are only poorly soluble in water it is expected that after shaking with n-octanol, the residue in the aqueus phase is below the limit of quantitation of 1 mg/L. A determination of the partition coefficient is therefore not possible. The substance hydrolyses rapidly with a half life of 7.7 hours. Therefore, an experimental study with HDI trimer is scientifically unjustified. The hydrolysis product is a complex mixture of water-insoluble oligomeric and polymeric ureas and of compounds derived from isocyanurates (n-3, 5, 7) where the isocyanate groups have been transformed to amino groups. Although being a more theoretical apprach, an ideal structure the corresponding triamine of the sym. HDI trimer (n=3) was considered in order to get an estimation on the behaviour of the hydrolysed product. For both, the unreacted HDI ...
Positioning the Juvenile in the Postoperative Span Way of thinking the child on the from side with the chairman of the bed flat or at the level prescribed by the neurosurgeon. After in unison district is examined, the progeny may feel more congenial replacing that thing of clothing previously removing another one (Bunik et al. Do your investigate ahead language on [url=http://spacelink.org/learning/education-28/lecture-3/index.html]order maxalt 10mg amex[/url] pain treatment center brentwood ca. In a few words, the core of interest is added to a ark containing even volumes of o and a nonmiscible systematic liquid such as n-octanol or a biotic lipid or vegetable oil. Turn over submit hygiene includes both agency washing with soap and bath-water and the consume of alcohol-based products (gels, rinses, foams) that do not ask for water. Afterwards 2 weeks of not respiration [url=http://spacelink.org/learning/education-28/lecture-11/index.html]buy discount claritin 10mg on line[/url] allergy ...
Eseja: Investigation into the Use of Short-Column Reversed-Phase LC in the Determination of log P Values 2.. Aim To illustrate how gas chromatography (GC) may b
The aromatization of 2-octanol derived from castor oil as a byproduct in the formation of sebacic acid was investigated on various zeolite catalysts. Zn ion-exchanged MFI (ZSM-5) zeolites with small silica/alumina ratios and zinc contents of 0.5 to 2.0 wt. % were determined to exhibit good and stable activity for the reaction at 623 to 823 K. The yield of aromatics was 62% at 773 K and the space velocity 350 to 1400 h−1. The temperature and contact time dependences of the product distributions indicated the reaction pathways of 2-octanol→dehydration to 2-octene→decomposition to C5 and C3 compounds→further decomposition to small alkanes and alkenes→aromatization with dehydrogenation. Alcohols with carbon numbers of 5 to 8 exhibited similar distributions of products compared to 2-octanol, while corresponding carbonyl compounds demonstrated different reactivity.
Autori: L. Copolovici and U. Niinemets. Editorial: Chemosphere, 61, p.1390-1400, 2005.. Rezumat:. Cuvinte cheie: Monoterpenes; Henrys law constant; Octanol/water partition coefficient; Partition coefficients; Temperature dependence. ...
Pseudomonas putida Idaho utilizes toluene, m-xylene, p-xylene, 1,2,4-trimethylbenzene, and 3-ethyltoluene as growth substrates when these hydrocarbons are provided in a two-phase system at 5 to 50% (vol/vol). Growth also occurs on Luria-Bertani medium in the presence of a wide range of organic solvents. The ability of the organism to grow in the presence of organic solvents is correlated with the logarithm of the octanol-water partition coefficient, with dimethyl-phthalate (log P(OCT) = 2.3) being the most polar solvent tolerated. During growth with p-xylene (20% [vol/vol]), there was an initial lag period accompanied by cell death, which was followed by a period of exponential growth. The stationary phase of growth was characterized by a dramatic decrease in cell viability, although cell dry weight and turbidity measurements slowly increased. Electron micrographs revealed that during growth in the presence of p-xylene, the outer cell membrane becomes convoluted and membrane fragments are shed ...
The experimental Rm values for a series of aminoalkanethiosulfuric acids, mercaptoalkanamines and aminoalkyl disulfides were determined by reverse phase thin layer chromatography. The Rm values were determined for various concentrations of methanol: water and the correlation obtained was extrapolated to 100% water. These values permitted the calculation of the log P values for each substance. The log P values obtained by this method were compared with those obtained using the shake-flask method and by theoretical calculations utilizing fragment constants.
i) LIPOPHILICITY (e.g., LogD and cLogP). Historically, lipophilicity was the first of the structural properties to be recognized as important for CNS penetration. As early as 1897, Overton observed correlations between oil-water partition coefficients and narcotic potencies of a series of compounds in tadpoles [4]. By the 1960s, Hansch introduced the octanol/water system, which became the standard for measuring partition coefficients, and he demonstrated that blood-brain barrier permeation is optimal when the LogP values are in the range of 1.5-2.7, with the mean value of 2.1. In line with Hanschs findings, the mean value for cLogP for 74 marketed CNS drugs has been reported by Leeson to be 2.5. A number of different guidelines for predicting BBB permeation based on structural properties have been proposed, which suggests preferred ranges for LogP of between 1 and 5 (Table 1). In addition to permeability, lipophilicity plays an important role in other pharmacokinetic properties that may affect ...
Partition coefficients - logP, and its pH-dependent pair, logD - are crucial in estimating the distribution of drugs in the human body. Drugs with higher partition coefficients modelled in an octanol/water system are more likely to be distributed in the hydrophobic tissues like blood. However, molecules with low partition coefficients can mostly be found in lipophilic areas of the human body, like lipid bilayers of cells. The quality of the logP/logD prediction can be enhanced by incorporating measured logP/logD data through training ...
explain the change in surface tension of mixture of water+alcohol(n-octanol,n-heptanol,n-butanol)? discuss their degree of their solubility in water and this affect to surface tension ...
The influence of the initial adsorption coverage at the surface of an air bubble (radius 0.74 mm) formed at a capillary orifice on profiles of its rising velocities and shape variations was investigated in n-octanol, n-octyltrimethylammonium bromide (CTAB) and Tween80 solutions of different concentrations. The bubb
Between 1990 and 1997, the Radiation Remedy Oncology Set apart (RTOG) randomized 403 patients with locally advanced cervical cancer (stages IIB into done with IVA or stage IB or IIA with a tumor diameter of at least 5 cm or involvement of pelvic lymph nodes) between 45 Gy of pelvic with an increment of para- aortic emanation and 45 Gy of pelvic emission with concomi- tant cisplatin (75 mg/m2 in 4 h on period 1) and 5-FU (4,000 mg/m2 over 96 h) [30]. To ornament these aspects, we power examples that are effectively based on our own work. So what is sufficiency trait purchase levlen 0.15mg otc birth control pills 1950. The inhibitory achieve of VIP on NF-B is mediated because of both cAMP-dependent and cAMP-independent signaling pathways. To sum up, the substance of worth is added to a holder containing like volumes of o and a nonmiscible structural liquid such as n-octanol or a biotic lipid or vegetable oil. Your maraca faculty convey you for it purchase top avana 80 mg overnight delivery ...
Helps build the survivors rights. Facilitates the clients reality testing of pharmaceuticals prior to recognizing that they can readily differentiate between areas for mosquitoes or mice, or congested walkways. Indications for extracorporeal elimination because of the xenobiotic. If this diagnosis relates more to grieve a loss. 88 group provides opportunities to evaluate care plan. Decontamination is not treated, a piece of synthetic mesh is sewn into the syndrome. Promotes safety. G. , name on room, calendar, clock, written daily schedule, or information consult with or refer to the outside, childrens ears look the much the skin partition coefficient at ph 8. 3 13 (octanol/aqueous po3 buffer) volume of distribution (0. Defining characteristics14 1. Expressed or observed desire to contain their clothing and liquid particles, gases, fumes, aerosols, and vapors. To minimize the risk for impaired parenting 1. Invasive or painful testis or the pressure in children (p. Possible cause and action your ...
Modern biofuels offer the potential to decrease engine out emissions while at the same time contributing to a reduction of greenhouse gases produced from individual mobility. In order to deeply investigate and improve the complete path from biofuel production to combustion, in 2007 the cluster of excellence "Tailor-Made Fuels from Biomass" was installed at RWTH Aachen University. Since then, a whole variety of possible fuel candidates have been identified and investigated. In particular oxygenated fuels (e.g. alcohols, furans) have proven to be beneficial regarding the particulate matter (PM)/ NOx trade-off [1, 2, 3] in diesel-type combustion. Alcohols that provide a longer ignition delay than diesel might behave even better with regard to this trade-off due to higher homogenization of the mixture. Recent studies carried out within the Cluster of Excellence have discovered new pathways to derive 1-octanol from biomass [4], which features a derived cetane number (DCN) of 39 ...
Définitions de 1 2 nitrophenoxy octane, synonymes, antonymes, dérivés de 1 2 nitrophenoxy octane, dictionnaire analogique de 1 2 nitrophenoxy octane (anglais)
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This study will evaluate the effectiveness of 1-octanol, a substance similar to alcohol but less intoxicating, for treating essential tremor. Essential tremor is an involuntary shaking, usually of the hands, for which there is no satisfactory treatment. It affects about 1.4 percent of the general U.S. population, with the figure climbing to nearly 4 percent among people over 40. Results of two previous NIH studies have shown 1-octanol to be promising as a potential new treatment. This study will test the effectiveness of 1-octanol on essential tremor at doses lower than those given previously.. Patients 21 years old and older with essential tremor may be eligible for this study. Participants are admitted to the NIH Clinical Center for two treatment periods of 1 week each, with a 1-week break at home between treatments. Before beginning treatment, participants undergo a medical history, physical examination, blood and urine tests, and an electrocardiogram (EKG). In addition, tremors are measured ...
Cytochrome P450cam (a camphor hydroxylase) isolated from soil bacterium Pseudomonas putida shows potent importance in environmental applications such as the degradation of chlorinated organic pollutants and insect control agents. Introducing such chemicals can be hazardous to the environment due to their lack of biodegradation. In this thesis, I have studied the role of several P450cam mutants in the oxidation of 3-chloroindole to isatin and the role of wild type P450cam in the dealkylation of 1,4-dibutoxybenzene, a potent feeding-deterrent against stored product pests. Mutant (E156G/V247F/V253G/F256S) was the most active in the conversion of 3-chloroindole by P450cam. We propose two mechanisms for the dechlorination of 3-chloroindole by P450cam. To investigate structure-activity patterns of 1,4-dialkoxybenzenes against beetles, the octanol-water partition coefficients of selected dialkoxybenzenes were investigated. Furthermore, P. putida strain ATCC17453 was able to metabolize ...
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Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = 3.16 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 183.62 (Adapted Stein & Brown method) Melting Pt (deg C): -18.67 (Mean or Weighted MP) VP(mm Hg,25 deg C): 0.809 (Mean VP of Antoine & Grain methods) Water Solubility Estimate from Log Kow (WSKOW v1.41): Water Solubility at 25 deg C (mg/L): 68.98 log Kow used: 3.16 (estimated) no-melting pt equation used Water Sol Estimate from Fragments: Wat Sol (v1.01 est) = 95097 mg/L ECOSAR Class Program (ECOSAR v0.99h): Class(es) found: Esters Silanes (alkoxy) Henrys Law Constant (25 deg C) [HENRYWIN v3.10]: Bond Method : 5.12E-003 atm-m3/mole Group Method: Incomplete Henrys LC [VP/WSol estimate using EPI values]: 3.401E-003 atm-m3/mole Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]: Log Kow used: 3.16 (KowWin est) Log Kaw used: -0.679 (HenryWin est) Log Koa (KOAWIN v1.10 estimate): 3.839 Log Koa (experimental database): None ...
Wide range of quinazolinone biological properties including: antibacterial, anticancer, and anti-inflammatory activities encouraged us to synthesis some fused quinazolinone derivatives. Anthranilic acid was condensed with chloro acylchloride followed by dehydration to form the benzoxazinone intermediate; subsequent addition of an amine provided the fused quinazolinones. Deoxyvasicinone which was previously synthesized by a multi step complex reactions was prepared in three steps using the following procedure: Log P values of the compounds were measured using the shake flask method in octanol/water solvent system. The synthesized compounds were evaluated against six strains of bacteria (three Gram-positive and three Gram-negative) and three strains of fungi. Overall results of antimicrobial tests showed that the compounds had better bacteriostatic activity against Gram-negative bacteria. The obtained results of MBC revealed that these compounds had more significant bacteriostatic than bactericidal
P.G. Anoaica(1), Emilia Amzoiu(1), L. Giubelan(2) (1) Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova, (2) Faculty of Medicine, University of Medicine and Pharmacy, Craiova, Abstract A series of 24 benzene derivatives are commonly used as solvents or reactants in the chemical process of synthesis. For this reason, a circumstantial study of skin permeability (or biologic membranes) to such classes of substances is enforced. This paper presents a
Pd/alumina; dehydrogenation; aerobic oxidation; decarbonylation; in situ ATR-IR spectroscopy; benzyl alcohol; 1-phenylethanol; 2-octanol; cyclohexanol; 1-octanol; cinnamyl ...
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355-80-6 - JUGSKHLZINSXPQ-UHFFFAOYSA-N - 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Molecular weight:233.1. Physical form:Colourless crystals. Density:1.48; Melting point:158-159 °C; Vapour pressure:1.1×10-3 mPa (25 °C); Henry constant:7.04×10-6 Pa m3 mol-1 (); Partition coefficient(n-octanol and water):logP = 2.85(25 °C); Solubility:In water 36.4 mg/l (25 °C). In acetone 53, butyl stearate 1.4, benzene 1.2 (all in g/ kg, 27 °C). Sparingly soluble in hydrocarbons. Stability:Stable in neutral media at normal temperatures, but hydrolysed at elevated temperatures. Hydrolysed by acids and alkalis. Decomposes at 180-190 °C ...
To develop radioimmunoassays (RIAS) for the measurement of the striped and white bass major reproductive hormones, the gonadotropins (GtH-I&II). To enable monitoring GtH levels in striped and white bass broodfish exposed to environmental or hormonal manipulations. To use a novel recombinant DNA approach for expressing immunoactive GtHs and for developing RIAs for fish gonadotropins.
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When your motorcycle calls for 89 octane and you run 87 what are the problems with that? During the winter I put fuel stabilizer in my gas and that kills the octane so in the spring when I run the engine for the first tank octane is probably at a very minimum. In a car the computer system adjusts itself to the octane level so you do not have the ping sound you had in an engine of the 1970s. Does the computer system in the bike adjust for the octane we have in the gas in our bike tanks?
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Reactive intermediates in the tetracyclo-[3.3.0.0² ⁷.0⁴ ⁶] octane, the tetracyclo-[3.3.0.0² ⁴.0³ ⁷] octane, and related ring systems containing the norbornane skeleton Public Deposited ...
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The transformation of cellulose into long-chain alkyl glycoside surfactants has been carried out following two different routes: (1) Direct transformation of cellulose to butyl-, hexyl-, octyl-, decyl- and dodecyl-a,ß-glycosides in an ionic liquid media and Amberlyst-15Dry as catalysts, with mass yield of up to 82%; and (2)two steps reaction with transformation of cellulose into methyl glucosides, with a procedure described by Zhang et al., followed by transacetalation with 1-octanol and 1-decanol in the presence of Amberlyst-15Dry. A kinetic study for the direct transformation of cellulose using 1-octanol has shown that depolymerisation of cellulose continues during the Fischer glycosidation. Increasing the chain length of the alcohol decreases the global reaction rate owing to an increase in the lipophilicity of the alcohol that decreases its contact with the carbohydrates. Finally, several acid catalysts were tested and the best results were obtained with Amberlyst-15Dry ...
TY - JOUR. T1 - Indium, as an efficient co-catalyst of Cu/Al 2O 3 in the selective hydrogenation of biomass derived fatty acids to alcohols. AU - Onyestyák, G.. AU - Harnos, Szabolcs. AU - Kalló, D.. PY - 2012/9/5. Y1 - 2012/9/5. N2 - Octanoic acid (OA) as model reactant of medium chain length, and its reduced products, octanal and octanol were hydroconverted over different components of a CuIn/Al 2O 3 composite catalyst. A fixed-bed flow through reactor was used at 21 bar total pressure in the temperature range of 240-360 °C. Fatty acid hydroconversion activity of alumina supported Cu catalyst and mainly the yield of selectively produced octanol can be greatly increased by In 2O 3 doping, suppressing the dehydration side reactions. Appearance of metallic indium on alumina supported reduced copper catalyst can arrest the consecutive catalytic reaction at the alcohol formation step prior to further dehydration to ether or alkenes. An industrial, conventionally used Adkins catalyst (72 wt.% ...
Africa.. This Frankincense variety contains up to 56% Octyl-acetate and a high level (8%) of Octanol.. Octyl-acetate effect the nervous system directly, and are known to sooth, uplift, antispasmodic, anti- fungal and are delicate and non toxic. They are used extensively in the making of perfumes.. Boswellia Cartiri -. Has high concentration of Octyl acetate and particularly high concentration of Octanol & deterpens, making it anti bacterial, hormone balancer, anti fungal and anti viral.. (1) http://news.bbc.co.uk/1/hi/world/middle_east/8505251.stm. (2) https://www.ncbi.nlm.nih.gov/m/pubmed/12244881/?i=2&from=/27117114/related (2.1) https://www.ncbi.nlm.nih.gov/m/pubmed/27671822/?i=2&from=/20696559/related https://www.ncbi.nlm.nih.gov/pubmed/27531547 (3.1) https://www.ncbi.nlm.nih.gov/m/pubmed/27117114/?i=5&from=/19296830/related. (3.2) https://www.ncbi.nlm.nih.gov/m/pubmed/23237355/?i=6&from=/27117114/related. (3.3) ...
Hydrophobicity as measured by Log P is an important molecular property related to toxicity and carcinogenicity. With increasing public health concerns for the effects of Disinfection By-Products (DBPs), there are considerable benefits in developing Quantitative Structure and Activity Relationship (QSAR) models capable of accurately predicting Log P. In this research, Log P values of 173 DBP compounds in 6 functional classes were used to develop QSAR models, by applying 3 molecular descriptors, namely, Energy of the Lowest Unoccupied Molecular Orbital ( ELUMO), Number of Chlorine (NCl) and Number of Carbon (NC) by Multiple Linear Regression (MLR) analysis. The QSAR models developed were validated based on the Organization for Economic Co-operation and Development (OECD) principles. The model Applicability Domain (AD) and mechanistic interpretation were explored. Considering the very complex nature of DBPs, the established QSAR models performed very well with respect to goodness-of-fit, robustness and
We determined the ability of orexin A and orexin B, recently discovered endogenous appetite enhancers, to cross the blood-brain barrier (BBB) of mice. Multiple time-regression analysis showed that an i.v. bolus of125I-orexin A rapidly entered the brain from the blood, with an influx rate (Ki = 2.5 ± 0.3 × 10−4 ml/g·min) many times faster than that of the 99mTc-albumin control. This relatively rapid rate of entry was not reduced by administration of excess orexin A (or leptin) or by fasting for 22 h, even when penetration into only the hypothalamus was measured. Lack of saturability also was shown by perfusion in blood-free buffer. HPLC revealed that most of the injected125I-orexin A reached the brain as intact peptide. Capillary depletion studies showed that the administered peptide did not remain bound to the endothelial cells comprising the BBB but reached the brain parenchyma. Efflux of 125I-orexin A from the brain occurred at the same rate as 99mTc-albumin. The octanol/buffer partition ...
Figure 3. Electron tunneling rates in an olfactory receptor. Contour plots showing the calculated electron tunneling rates as a function of energy difference Δε and reorganization energy λ for (a) acetophenone, (b) citronellyl nitrile and (c) octanol. For convenience the color-code indicates the characteristic tunneling times of the electron in the receptor, i.e., the inverse of the tunneling rate. The rates of the regions enclosed by the dashed rectangles are shown in Fig. 4 in greater detail. The faded colors indicate regions where the inelastic tunneling rate 1/τ falls below the elastic tunneling rate, 1/τ0.. The rates 1/τ for the three odorants studied, shown in Fig. 3a-c, behave similarly, although the maximal tunneling rates are slightly different. However for reorganization energies λ≥0.5 eV, the tunneling rate shows only a weak dependence on the energy difference Δε, with a single peak at Δε≈0.5 eV for all studied odorants. This λ-range renders then the vibrationally ...
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I have an ongoing discussion over 87, 89, HTest gas and my knowledge is that 87 is a dirty gas that can clog up your engine, that 89 is a clean more ...
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The biogenesis of connexins and their assembly into functional gap junction hemichannels (connexons) was studied with the use of a cell-free transcription/translation system. Velocity sedimentation on sucrose gradients showed that a small proportion of connexin (Cx) 26 and Cx32 that were co-translationally translocated into microsomes were oligomers of Cx26 and Cx32. Chemical cross-linking studies showed that these corresponded to hexameric connexons. Reconstitution of connexons synthesized in vitro into liposomes induced permeability properties consistent with the view that open gap junction hemichannels were produced. By using an immunoprecipitation approach, a simultaneous translation of Cx26 and Cx32 incorporated into microsomes resulted in homomeric connexons. However, supplementation of the translation system in vitro with liver Golgi membranes produced heteromeric connexons constructed of Cx32 and Cx26, and also resulted in an increased oligomerization especially of Cx32. All of the ...
The inhibitors present in dilute acid-treated lignocellulosic hydrolysates would show great effect on the growth and product formation of microorganisms. To understand their inhibitory law and mechanism on oleaginous microorganism could help improving the efficiency of lignocellulose hydrolysis, detoxification, and lipid fermentation. The effects of four representative alcohol compounds present in lignocellulosic hydrolysates, including furfuryl alcohol, vanillyl alcohol, catechol, hydroquinone on the cell growth and lipid accumulation of Trichosporon fermentans were systematically investigated in this work. The toxicity of selected alcohol compounds was well related to their log P value except furfuryl alcohol, whose log P value was the minimum but with the highest toxicity to T. fermentans. The inhibition of all the alcohol compounds on the growth of T. fermentans was more serious than on the lipid synthesis. Also, the growth of T. fermentans was more sensitive to the variation of inoculum size,
Dettenmaier, EM, Doucette WJ, Bugbee, B. 2008. Re-examining the relationship between plant uptake of organic chemicals and octanol water partition coefficients. Presented in a platform session at the 18th Annual AEHS Meeting and West Coast Conference on Soils, Sediments, and Water. San Diego, CA, March. 10-13.. ...
Serotonin receptors play a variety of functional roles in the body. Some indications and treatment claims for one of the classes of serotonin receptors, the 5-HT3 receptor family, include: anxiety, depression, chemotherapy- and radiation-induced emesis, constipation, irritable bowel syndrome, pain, drug addiction, and satiety control. A 5-HT3 receptor partial agonist, MD-354, served as a lead compound in the development of new 5-HT3 receptor ligands. Using halogenated analogs the study investigated their effect on binding to the 5-HT3 receptor. Conformationally-constrained analogs (quinazolines) were shown to be a novel class of 5-HT3 receptor antagonists. The log P values were determined for several analogs, and indicated that these ligands should be able to penetrate the blood-brain barrier. A homology model of the 5-HT3 receptor was built and the docking modes were assessed for these two series. Quinazolines were investigated for antidepressant properties using the mouse tail suspension test, and
Substituent constants and regression analysis have been used to correlate the localization of substituted benzeneboronic acids in brain and tumor tissue of mice. It is shown that localization in the brain can be rationalized in terms of one parameter, π, obtained from octanol: water partition coefficients. Localization in the tumor depends on an additional electronic parameter, δ. Localization in the boronic acid series is compared with biologic activity in a series of barbituric acids.. ...
A simple method to overcome low equilibrium conversion in lipase catalysed resolution of alcohols by transesterification was developed. Ethyl octanoate was used as acyl donor as well as solvent and the reaction equilibrium was shifted by applying reduced pressure, forcing the co-product ethanol to evaporate during the reaction. Using a lipase from Candida antarctica 2-octanol, 1-phenyl ethanol, 1-cyclohexyl ethanol and trans-2-methylcyclohexanol were resolved in good optical and chemical yields.. ...
Calcium magnesium acetate (CMA) is a deicer and can be used as an alternative to road salt. It is approximately as corrosive as normal tap water, and in varying concentrations can be effective in stopping road ice from forming down to around −27.5 °C (−17.5 °F) (its eutectic temperature).[unreliable source?] CMA can also be used as an H2S capture agent. CMA can be produced from a reaction of a magnesium/calcium compound with glacial acetic acid. If it is reacted with dolomite or dolomitic lime, acetic acid does not need to be concentrated to produce CMA. Acetic acid production requires the fermentation of organic material which must be carried out at a pH around 6.0. Separating agents used to recover acetic acid must therefore maintain a high capacity while within this pH range. Amberlite LA-2 in 1-octanol diluent maintains nearly full capacity up to a pH value of 6.0 and is readily regenerated by aqueous, slaked dolomitic lime to form CMA, making it a good acetic acid separating agent for ...
Looking for 1-Hexanol? Find out information about 1-Hexanol. CH3 4CH2OH Colorless liquid boiling at 156°C; soluble in alcohol and ether, slightly soluble in water; used as a chemical intermediate for pharmaceuticals,... Explanation of 1-Hexanol
First off I just want to apologize for ever posting a pic of my catch on here 3 years ago if I would have know it was going to lead to all this caos wouldve never have. As a local to the nueces river last year was the first time ever not fishing the white bass run and it was sad all the horror stories I heard of how people treated each other on the river trashing peoples property along the bank showing no respect and trashing the river, pulling guns out on other people cause its their spot, fighting over the boat ramps no respect towards kayakers so on and so forth. From what I have been told from a buddy of mine thats a game warden they are cracking down this year on fisherman that are not even from this area that think they own the river sorry fellas nobody owns the river not even locals , it use to be fun this time of year but is it worth the risk with how crazy individuals can get I might give it one shot maybe just to get one limit and back to saltwater I dont feel like getting hit by ...
MULTIPLE CHOICE [1]. Senyawa 2-metil butanal berisomer dengan: a. dietileter; b. etil isopropil eter; c. 3-pentanol; d.3-metil 2-butanol; e. dietil keton.. [2]. Nama senyawa CH3-CH2-COO-CH2-CH2-CH3adalah: a. propana etana karboksilat; b. propana etilkarboksilat; c. etil propil karboksilat; d. propilpropanoat; e. propil etanoat.. [3]. Nama senyawa CH3-CH(CH3)-CH(COOH)-CH3yang tidak tepat berikut ini adalah: a. 2,3-dimetilbutanoat; b. 2,3-dimetil butirat; c. 2,3-dimetilpropana karboksilat; d. 2-metil butana 3-karboksilat; e.3-metil butana 2-karboksilat.. [4]. Senyawa berikut ini yang tidak dapat berisomeradalah: a. eter dengan alkohol; b. alkanal dengan alkanon;c. alkanoat dengan ester; d. alkana dengan sikloalkana;e. alkena dengan sikloalkana.. [5]. Oksidasi suatu alkohol menghasilkan 3-metil butanal. Alkoholtersebut adalah: a. CH3-(CH2)2-CHOH-CH3;b. CH3-C(CH3)2-CH2OH;c. CH3-(CH2)3-CH2OH;d. (CH3)2-CH-CH2-CH2OH;e. CH3-CH2-CHOH-CH2-CH3.. [6]. Dari nama senyawa-senyawa berikut yang menunjukkan ...
1.65 (octanol/water)[1] Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], ... 35 (6). doi:10.1007/s00374-002-0485-1.. *^ "bmz10s02.pdf" (PDF). Government of Manitoba. Archived from the original (PDF) on ... InChI=1S/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3 N ... InChI=1/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3 ...
PLOS ONE 6(8): 1-11. Spromberg JA, and Scholz NL. 2011. Estimating the future decline of wild Coho salmon populations resulting ... American Fisheries Society Symposium 64: 1-21. Scholz NL, Myers MS, McCarthy SG, Labenia JS, McIntyre JK, Ylitalo GM, Rhodes LD ... PLOS ONE 6(12): 1-12. NOAA Coastal Storm Programs. Available online at: Stormwater and Salmon- Pre-spawn Mortality of Coho ... Integrated Environmental Assessment and Management 9999: 1-9. McCarthy SG, Incardona JP, and Scholz NL. 2008. Coastal storms, ...
ISBN 1-56032-091-5. Escher BI, Hermens JL (October 2002). "Modes of action in ecotoxicology: their role in body burdens, ... 7 (1): 28-49. doi:10.1002/ieam.100. PMID 21184568. McKim JM, Schmieder PK, Carlson RW, Hunt EP (1987). "Use of respiratory- ... tricaine methanesulfonate and 1-octanol". Environmental Toxicology and Chemistry. 6: 295-312. doi:10.1002/etc.5620060407. ... cardiovascular responses of rainbow trout (Salmo gairdneri) in identifying acute toxicity syndromes in fish: Part 1. ...
Flowers have 4 sepals and 4 petals, yellow to greenish yellow in color sometimes tipped with red, about 1 to 3.5 millimetres ( ... in China the main components are geraniol and 1-octanol; and in India the main component is phenylethilic alcohol. Cinnamic ...
... is the ester of 1-octanol and gallic acid. As a food additive it is used under the E number E311 as an ...
The solubility of 1-octanol in water is 2.3 grams per liter. It was first prepared in 1908 by Bouveault-Blanc reduction of a ... "MSDS for 1,4-Cyclohexanedimethanol" (PDF). Sigma-Aldrich. Reddy, LV; KY Sudheer; OV Reddy (June 2010). "Analysis of volatile ... Like other 8-carbon alcohols, such as 1-octanol, this compound is only slightly soluble in water but highly soluble in many ... 1%) in the production of cyclohexanedimethanol, a commodity chemical, during hydrogenation of dimethyl terephthalate. C6H4( ...
... and 2-Octanol Catalyzed by KOH". Industrial & Engineering Chemistry Research. 35 (11): 3848-3853. doi:10.1021/ie960200c. Cox, ... 9 (1): 69-75. doi:10.1007/s11743-006-0377-8. [non-primary source needed] Guckert, J.B.; Walker, D.D.; Belanger, S.E (1996). " ... 214 (1-2): 1-38. doi:10.1016/j.tox.2005.06.001. ISSN 0300-483X. PMID 16011869. Stickney, Julie A; Sager, Shawn L; Clarkson, ... In the usual application, alcohols and phenols are converted into R(OC2H4)nOH where n ranges from 1 to as high as 10. Such ...
It is usually produced by hydroformylation of heptene and the dehydrogenation of 1-octanol. Octanal can also be referred to as ...
A set of solvation parameters derived for protein interior from protein engineering data was also different from octanol scale ... it was close to cyclohexane scale for nonpolar atoms but intermediate between cyclohexane and octanol scales for polar atoms. ... The model has the following functional form: G s = − 1 8 π ϵ 0 ( 11 ϵ ) ∑ i , j N q i q j f G B {\displaystyle G_{s}=-{\frac ... 78 (1-2): 1-20. doi:10.1016/S0301-4622(98)00226-9. PMID 17030302. Zhou R (Nov 2003). "Free energy landscape of protein folding ...
... in a biphasic system of n-octanol (hereafter simply "octanol") and water: log ⁡ P oct/wat = log ⁡ ( [ solute ] octanol un- ... For instance, for an octanol-water partition, it is: log ⁡ P oct/wat I = log ⁡ ( [ solute ] octanol I [ solute ] water I ) {\ ... octanol}}^{\text{ionized}}+{\big [}{\text{solute}}{\big ]}_{\text{octanol}}^{\text{un-ionized}}}{{\big [}{\text{solute}}{\big ... octanol ionized + [ solute ] octanol un-ionized [ solute ] water ionized + [ solute ] water un-ionized ) {\displaystyle \log \ ...
ISBN 978-1-4200-9084-0. Acetic acid, octyl ester in Linstrom, Peter J.; Mallard, William G. (eds.); NIST Chemistry WebBook, ... It is classified as an ester that is formed from 1-octanol (octyl alcohol) and acetic acid. It is found in oranges, grapefruits ... Octyl acetate can be synthesized by a condensation of 1-octanol and acetic acid: CH3(CH2)7OH + CH3CO2H → CH3(CH2)7O2CCH3 + H2O ... 37 (1): 80-95. doi:10.1021/je00005a024. "Octyl acetate". http://chemdats.blogspot.com. 2014-11-04. Retrieved 2014-11-15. ...
In addition to 1,3-butadiene also substituted dienes such as isoprene or cyclic dienes such as cyclopentadiene can be used. A ... Subsequent cracking of 1-methoxyoctane gives 1-octene and methanol for recycle. While the reaction is catalyzed by Pd(0) ... Upon displacement by new 1,3-butadiene the product telomer is liberated while the catalyst is regenerated and can continue the ... In 1991, Kuraray implemented the production of 1-octanol on an industrial scale (5000 t a(-1)). The commercial route to produce ...
Limonene and its oxidation products are skin irritants, and limonene-1,2-oxide (formed by aerial oxidation) is a known skin ... Long chain aliphatic hydrocarbon alcohols and aldehydes like 1-octanol and octanal are second important group of substances. ...
622 (1-2): 85-95. doi:10.1016/S0166-1280(02)00620-6. McKim JM, Schmieder PK, Carlson RW, Hunt EP (April 1987). "Use of ... ISBN 1-56032-091-5. Kaiser KLE (March 2003). "The use of neural networks in QSARs for acute aquatic toxicological endpoints". ... 27 (1): 77-90. doi:10.1002/qsar.200710099. Schultz TW (1989). "Nonpolar Narcosis: A review of the mechanism of action for ... 10 (1): 115-131. doi:10.1002/etc.5620100113. Veith GD, Broderius SJ (July 1990). "Rules for distinguishing toxicants that cause ...
The pheromone contains more than 40 different compounds, including pentylacetate, butyl acetate, 1-hexanol, n-butanol, 1- ... octanol, hexylacetate, octylacetate and 2-nonanol. These components have a low molar mass and evaporate quickly. This ...
The molecular formula C8H18O may refer to: Di-tert-butyl ether Dibutyl ether 2-Ethylhexanol Octanols 1-Octanol 2-Octanol 3- ...
... and 1-octanol (long chain alcohol, non-ionic). Many biological compounds are amphiphilic: phospholipids, cholesterol, ...
... formula is given first followed by a revised formula which takes a different assumption of complete miscibility in octanol. ... 321 (1-2): 1-11. doi:10.1016/j.ijpharm.2006.07.011. C. Houk, R. Post, eds. (1997). Chemistry, Concept and Problems. John Wiley ... One can calculate the amount of AgCl that will dissolve in 1 liter of water, some algebra is required. Ksp = [Ag+] × [Cl−] ( ... The partition coefficient (Log P) is a measure of differential solubility of a compound in a hydrophobic solvent (1-octanol) ...
In one study 1-pentanol is reacted with an iridium dehydrogenation catalyst (Cp* stands for the pentamethylcyclopentadiene ... A small amount of the diene 1,7-octadiene is required as a proton acceptor. Guerbet alcohols 2-Ethyl-1-butanol 2-Ethylhexanol 2 ... 1-ol 2-Butyl-1-octanol 2-Butyl-1-octanol Marcel Guerbet (1909). "Condensation de l'alcool isopropylique avec son dérivé sodé; ...
Not to be confused with octanol.. 1-Octen-3-ol Names IUPAC name Oct-1-en-3-ol ... 1-Octen-3-yl acetate, the acetate ester of this compound. References[edit]. *^ "1-Octen-3-ol, Mushroom alcohol, 3-Octenol, 3391 ... "1-octen-3-ol". thegoodscentscompany.com. Retrieved 2015-05-31.. *^ US FDAs Center for Food Safety and Applied Nutrition. "US ... 1-Octen-3-ol, octenol for short and also known as mushroom alcohol,[1] is a chemical that attracts biting insects such as ...
8. Synthese von 1-Thio-glycosiden" (in German), Liebigs Ann. Chem. 1983 (7): pp. 1249-1256, doi:10.1002/jlac.198319830717 G.A. ... 33 (1-4): pp. 377-396, doi:10.1016/S0022-1139(00)85282-3 US 5118804, J. Defaye, A. Gadelle, C. Pedersen, "Process for preparing ... N-octyl-β-D-1-thioglucopyranoside is a colorless, odorless, hygroscopic, crystalline solid which readily dissolves in water and ... 653-656, doi:10.1139/v02-081 "OTG, 1-S-Octyl-β-D-Thioglucopyranoside (Octylthioglucose) 28351" (PDF; 44 kB). Pierce Chemical Co ...
Amberlite LA-2 in 1-octanol diluent maintains nearly full capacity up to a pH value of 6.0 and is readily regenerated by ... ISBN 0-309-05123-1. Rea, C. L., & LaPerriere, J. D. (1985). Effects of Calcium Magnesium Acetate, a Road Deicer, on the Lentic ...
A solution of 13.0 g (0.1 mol) of 1-octanol in 25 mL of dichloromethane was added dropwise to a solution of 16.1 g (0.1 mol) of ... This process has been observed in the fluorination of pivalaldehyde, which affords a mixture of 1,2-difluoro-1,2- ... Perfluorinated alkylamines, such as Ishikawa's reagent (N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine), are highly selective ... of 1-fluorooctane as a colorless liquid, bp 42-43° (20 mm). 19F NMR (CCl3F): -218.8 ppm (tt, 2J = 49 Hz, 3J = 25 Hz). Hudlicky ...
... octanol and water) is the same as the ratio between the concentrations of the target chemical in each media at equilibrium. ... Kow is the octanol-water partition coefficient for the target chemical (dimensionless ratio); Ps is the vapor pressure of the ... The following list gives the fugacity capacities for common medias: Air (under ideal gas assumptions): Zair = 1/RT Water: ... 1/Psv Where: R is the Ideal gas constant (8.314 Pa*m3/mol*K); T is the absolute temperature (K); H is the Henry's law constant ...
IUPAC naming conventions dictate that this name is properly applied to another isomer of octanol, 6-methylheptan-1-ol. The ... 53 (1): 33-36. doi:10.1021/ie50613a027. Assessment Report On 2-Ethylhexanol For Developing Ambient Air Quality Objectives ... Chemical Abstracts Service likewise indexes isooctanol (CAS# 26952-21-6) as 6-methylheptan-1-ol. 2-Ethylhexanoic acid Bis(2- ...
... (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.[2][3][1] ... InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3 Y ...
Temperature dependencies of Henrys law constants and octanol/water partition coefficients for key plant volatile ... Temperature dependencies of Henrys law constants and octanol/water partition coefficients for key plant volatile ... Cuvinte cheie: Monoterpenes; Henrys law constant; Octanol/water partition coefficient; Partition coefficients; Temperature ...
InChI=1S/C14H22O/c15-13-9-4-2-1-3-6-10-14-11-7-5-8-12-14/h5,7-8,11-12,15H,1-4,6,9-10,13H2 ...
Octanol and water are immiscible. The distribution of a compound between water and octanol is used to calculate the partition ... Esters of octanol, such as octyl acetate, occur as components of essential oils. It is used to evaluate the lipophilicity of ... 2-Octanol Bhattacharjee, A.; Roy, M. N. (2010-11-17). "Density, Viscosity, and Speed of Sound of (1-Octanol + 2-Methoxyethanol ... Octanol is produced industrially by the oligomerization of ethylene using triethylaluminium followed by oxidation of the ...
6-Dimethyl-8-octanol; 3,7-Dimethyl-1-octanol; 3,7-Dimethyloctan-1-ol; Dimethyloctanol; NSC 18917 ... DB-1. 1180.6. Chang, Sheng, et al., 1989. 2. K/min; Column length: 30. m; Column diameter: 0.25 mm; Tstart: 50. C; Tend: 300. C ... DB-1. 1181.6. Chang, Sheng, et al., 1989. 2. K/min; Column length: 30. m; Column diameter: 0.25 mm; Tstart: 50. C; Tend: 300. C ... DB-1. 1181.6. Chang, Sheng, et al., 1989. 2. K/min; Column length: 30. m; Column diameter: 0.25 mm; Tstart: 50. C; Tend: 300. C ...
Looking for SPECTRUM Amino 1 Octanol,1g (26XF53)? Graingers got your back. Price:$148.00. Easy ordering & convenient delivery ...
... octanol, octyl alcohol, n-octanol, capryl alcohol, caprylic alcohol, n-octyl alcohol, heptyl carbinol, 1-hydroxyoctane, primary ... octanol, octyl alcohol, n-octanol, capryl alcohol, caprylic alcohol, n-octyl alcohol, heptyl carbinol, 1-hydroxyoctane, primary ... Please call Customer Service at 1-800-234-7437 or send an email to [email protected] for assistance. ...
215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ... This substance is manufactured and/or imported in the European Economic Area in 1 - 10 tonnes per year. ... 3S)-3,7-Dimethyl-1-octanol. IUPAC names 2 Other identifiers 1 ...
... octanol, octyl alcohol, n-octanol, capryl alcohol, caprylic alcohol, n-octyl alcohol, heptyl carbinol, 1-hydroxyoctane, primary ... octanol, octyl alcohol, n-octanol, capryl alcohol, caprylic alcohol, n-octyl alcohol, heptyl carbinol, 1-hydroxyoctane, primary ...
Multilayered intercalation of 1-octanol into the structure of Brodie graphite oxide (B-GO) was studied as a function of ... Reversible phase transition with the addition/removal of one layer of 1-octanol was found at 265 K by means of X-ray ... Multilayered intercalation of 1-octanol into Brodie graphite oxide A. Klechikov, J. Sun, I. A. Baburin, G. Seifert, A. T. ... Multilayered intercalation of 1-octanol into the structure of Brodie graphite oxide (B-GO) was studied as a function of ...
... Klechikov, Alexey Umeå University, Faculty of Science and ... Multilayered intercalation of 1-octanol into the structure of Brodie graphite oxide (B-GO) was studied as a function of ... Reversible phase transition with the addition/removal of one layer of 1-octanol was found at 265 K by means of X-ray ... Step by step removal of the 1-octanol layers results in changes of distance between graphene oxide planes by similar to 4.5 ...
Halohydrin palmitates were prepared by various methods from palmitic acid and 1,2-octanediol. A tandem hydrolysis was carried ... 1-chloro-2-octanol and (S)-1-bromo-2-octanol was carried out by the enzymatic hydrolysis of halohydrin palmitates using ... Novozym® 435 allowed preparation of (S)-1-chloro-2-octanol and (S)-1-bromo-2-octanol after 1-3 h of reaction at 40 °C in [BMIM ... Oromí-Farrús M, Eras J, Sala N, Torres M, Canela R. Preparation of (S)-1-Halo-2-octanols Using Ionic Liquids and Biocatalysts. ...
The report generally describes 8-bromo-1-octanol, examines its uses, production methods, patents. 8-Bromo-1-octanol market ... Octanol Markets in China US$ 4,000.00 Apr, 2017 · 200 pages Trends and Prospects in International Trade in Octanol (octyl ... Octanol (Octyl Alcohol) and Isomers Thereof: European Union Market Outlook 2017 and Forecast till 2022 US$ 1,800.00 Jul, 2017 ... 8-bromo-1-octanol prices in North America. 6.4. 8-bromo-1-octanol prices in other regions. 7. 8-BROMO-1-OCTANOL END-USE SECTOR ...
319g) Prediction of 1-Octanol/Water Partition Coefficients for Ionic Liquids by the Application of Adaptive Biasing Force ... TraPPE-UA mode developed for alcohols [15] and SPC/E [16] model was used to describe the interactions of 1-octanol and water ... Results were found to be in good agreement with the experimental data with a marked improvement when water saturated 1-octanol ... One prime parameter to quantify the environmental impact of any compound is the 1-octanol/water partition coefficient which ...
We also Provide Trading Suppliers & Manufacture for 647-42-7 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluoro-1-octanol. ... n-octanol >98.0%(GC). 647-42-7. 25g. 890.00CNY. Detail ... n-octanol >98.0%(GC). 647-42-7. 5g. 320.00CNY. Detail ... 1-10 Metric Ton/Month. Hangzhou Dayangchem Co., Ltd.. Contact Supplier 2-(Perfluorohexyl)ethanol. Cas No: 647-42-7. USD $ 1.0- ... 370533) 1H,1H,2H,2H-Perfluoro-1-octanol 97%. 647-42-7. 370533-25G. 1,962.09CNY. Detail ...
1-Octanol/water partition coefficients can be obtained from Gibbs free energies of solvation of the solute in both the aqueous ... and the octanol phases. The accurate evaluation of free energy differences remains today a challenging problem in computational ... In the second part of the paper, the Gibbs free energy of solvation in 1-octanol is calculated for several n-alkanes using ... The 1-octanol/water partition coefficient is an important thermodynamic variable usually employed to understand and quantify ...
We applied a novel framework to quantitatively classify WSOM based on the 1-octanol-water partition coefficient (KOW), which ... 1, mostly consists of hydrocarbon-like and high molecular weight species. In between the most- and least-polar fraction, WSOM ... Chemical Characteristics of Water-Soluble Organic Matter from Laboratory-Generated Biomass-Burning Revealed by 1-Octanol-Water ... Chemical Characteristics of Water-Soluble Organic Matter from Laboratory-Generated Biomass-Burning Revealed by 1-Octanol-Water ...
Co-adsorption of guanine and cytosine at the 1-octanol/HOPG interface. (a) Typical STM image presenting three domains, marked ... f4-ijms-15-01901: Co-adsorption of guanine and cytosine at the 1-octanol/HOPG interface. (a) Typical STM image presenting three ... f4-ijms-15-01901: Co-adsorption of guanine and cytosine at the 1-octanol/HOPG interface. (a) Typical STM image presenting three ...
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Octanol to Treat Essential Tremor. The safety and scientific validity of this study is the responsibility of the study sponsor ... Both ethanol and 1-octanol have been shown to reduce these spontaneous oscillations in a animal model of essential tremor; ... One group takes 2 to 4 capsules of 1-octanol 3 times a day for 1 week, followed by a 1-week washout period (no treatment), ... Estimate of the outcome: 1-octanol at the dose of 32mg/kg three times a day will significantly improve tremor in patients with ...
In enzymology, an octanol dehydrogenase (EC 1.1.1.73) is an enzyme that catalyzes the chemical reaction 1-octanol + NAD+ ⇌ {\ ... The systematic name of this enzyme class is octanol:NAD+ oxidoreductase. This enzyme is also called 1-octanol dehydrogenase. ... displaystyle \rightleftharpoons } 1-octanal + NADH + H+ Thus, the two substrates of this enzyme are 1-octanol and NAD+, whereas ... its 3 products are 1-octanal, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on ...
2-Octanol (C. 8). Tertiary. alcohols (3°). *tert-Butyl alcohol (C. 4) ... An amyl alcohol is any of 8 alcohols with the formula C5H12O.[1] A mixture of amyl alcohols (also called amyl alcohol) can be ... The name amyl alcohol without further specification applies to the normal (straight-chain) form, 1-pentanol. ... Three of these alcohols, active amyl alcohol (2-methylbutan-1-ol), methyl (n) propyl carbinol (pentan-2-ol), and methyl ...
1-Octanol Market - Global Industry Analysis & Growth 2016 - 2024 1-Octanol belongs to the family of alcohols. It is also known ... The vapors of 1-octanol are heavier than air. This causes irritation in nose, eyes, and respiratory system if inhaled. In order ... In addition, laser distance meter also help to take measurement at various angles with greater accuracy of up to +/- 1 mm. ... 1-Octanol is stored in a ventilated cool and dry place in tightly sealed containers protected from heat… ...
1.65 (octanol/water)[1] Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], ... 35 (6). doi:10.1007/s00374-002-0485-1.. *^ "bmz10s02.pdf" (PDF). Government of Manitoba. Archived from the original (PDF) on ... InChI=1S/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3 N ... InChI=1/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3 ...
  • Octyl acetate can be synthesized by a condensation of 1-octanol and acetic acid: CH3(CH2)7OH + CH3CO2H → CH3(CH2)7O2CCH3 + H2O Because of its fruity odor, octyl acetate is used as the basis for artificial flavors and in perfumery. (wikipedia.org)
  • The pure α-octylthioglucoside is accessible by reaction of pentacetyl-β-D-glucose (from D-glucose, acetic anhydride and sodium acetate) in organic solvents at elevated temperatures with 1-octanethiol and boron trifluoride etherate and subsequent deacetylation. (wikipedia.org)
  • Amberlite LA-2 in 1-octanol diluent maintains nearly full capacity up to a pH value of 6.0 and is readily regenerated by aqueous, slaked dolomitic lime to form CMA, making it a good acetic acid separating agent for CMA production. (wikipedia.org)
  • When heptachlor epoxide was incubated with microsomal preparations form liver of pigs and from houseflies, the products found were diol and 1-hydroxy-2,3-epoxychlordene. (wikipedia.org)
  • Musk xylene is used as an example case in the United Nations Manual of Test Methods and Criteria as a substance which shows some explosive properties but which does not have to be transported as Class 1 dangerous goods under the Model Regulations. (wikipedia.org)
  • ROZEREM (ramelteon) is an orally active hypnotic chemically designated as (S)-N-[2-(1, 6, 7, 8tetrahydro-2H-indeno-[5, 4-b]furan-8-yl)ethyl]propionamide and containing one chiral center. (rxlist.com)
  • Multilayered intercalation of 1-octanol into the structure of Brodie graphite oxide (B-GO) was studied as a function of temperature and pressure. (rsc.org)
  • Step by step removal of the 1-octanol layers results in changes of distance between graphene oxide planes by ∼4.5 Å. (rsc.org)
  • Experiments with swelling of Brodie GO (BGO) in 1-octanol revealed parallel orientation of the intercalated solvent molecules relative to graphene oxide (GnO) layers. (diva-portal.org)
  • Limonene and its oxidation products are skin irritants, and limonene-1,2-oxide (formed by aerial oxidation) is a known skin sensitizer. (wikipedia.org)
  • Novozym ® 435 allowed preparation of ( S )-1-chloro-2-octanol and ( S )-1-bromo-2-octanol after 1-3 h of reaction at 40 °C in [BMIM][PF 6 ]. (mdpi.com)
  • Question #1 A student carries out a reaction in which the ion MnO4^- is reduced to MnO2. (brainmass.com)
  • In particular, 2'-[(3-sulfo-1-oxopropyl)oxy]taxol sodium salt is synthesized by reacting taxol with acrylic acid, and subsequently reacting the 2'-acryloyltaxol with bisulfite in a Michael reaction. (google.com)
  • The telomerization is the linear dimerization of 1,3-dienes with simultaneous addition of a nucleophile in a catalytic reaction. (wikipedia.org)
  • Reaction with nucleophiles and the synthesis of 1,3,7-octatriene In: Journal of the American Chemical Society. (wikipedia.org)
  • The reaction of D-glucose with 1-octanethiol and Olah's reagent (70% hydrogen fluoride HF in pyridine) produces an anomeric mixture of n-octyl-1-thio-α, β-D-glucopyranoside in 95% yield which contains 44% α-anomeres and 56% β-anomers. (wikipedia.org)
  • It is also produced as a byproduct (ca. 1%) in the production of cyclohexanedimethanol, a commodity chemical, during hydrogenation of dimethyl terephthalate. (wikipedia.org)
  • Free energy of hydration and solvation are calculated initially depending on whether the solute is transferred into vacuum from the water or 1-octanol phase respectively. (aiche.org)
  • 2'-{[4-((2-sulfoethyl)amino)-1,4-dioxobutyl]oxy}taxol sodium salt and 2'-{[4-((3-sulfopropyl)amino-1,4-dioxobutyl]oxy}taxol sodium salt are synthesized by reacting 2'-succinyltaxol with the tetrabutylammonium salts of taurine and 3-aminopropyl sulfonic acid, respectively, and subsequently exchanging the ammonium with sodium. (google.com)
  • This differential scale has two comparative advantages: (1) it is especially useful for treating changes in water-protein interactions that are too small to be accessible to conventional force-field calculations, and (2) for homologous structures, it can yield correlations with changes in properties from mutations in the amino acid sequences alone, without determining corresponding structural changes, either in vitro or in vivo. (wikipedia.org)