Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.Isothiocyanates: Organic compounds with the general formula R-NCS.Naphthalenesulfonates: A class of organic compounds that contains a naphthalene moiety linked to a sulfonic acid salt or ester.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Thiocyanates: Organic derivatives of thiocyanic acid which contain the general formula R-SCN.Naphthols: Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.Musculoskeletal Diseases: Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Medicare Assignment: Concept referring to the standardized fees for services rendered by health care providers, e.g., laboratories and physicians, and reimbursement for those services under Medicare Part B. It includes acceptance by the physician.1-Naphthylisothiocyanate: A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Folklore: The common orally transmitted traditions, myths, festivals, songs, superstitions, and stories of all peoples.Phonetics: The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)Imagery (Psychotherapy): The use of mental images produced by the imagination as a form of psychotherapy. It can be classified by the modality of its content: visual, verbal, auditory, olfactory, tactile, gustatory, or kinesthetic. Common themes derive from nature imagery (e.g., forests and mountains), water imagery (e.g., brooks and oceans), travel imagery, etc. Imagery is used in the treatment of mental disorders and in helping patients cope with other diseases. Imagery often forms a part of HYPNOSIS, of AUTOGENIC TRAINING, of RELAXATION TECHNIQUES, and of BEHAVIOR THERAPY. (From Encyclopedia of Human Behavior, vol. 4, pp29-30, 1994)Piperonyl Butoxide: An insecticide synergist, especially for pyrethroids and ROTENONE.Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Butylated Hydroxytoluene: A di-tert-butyl PHENOL with antioxidant properties.Buthionine Sulfoximine: A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.Methionine SulfoximinePesticide Synergists: Chemicals that, while not possessing inherent pesticidal activity, nonetheless promote or enhance the effectiveness of other pesticides when combined.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro. (1/67)The acute hepatotoxicity induced by alpha-naphthylisothiocyanate (ANIT) in rats is manifested as neutrophil-dependent necrosis of bile duct epithelial cells (BDECs) and hepatic parenchymal cells. This hepatotoxicity mirrors that of drug-induced cholangiolitic hepatitis in humans. Since BDECs are primary targets of ANIT-induced toxicity, we hypothesized that after exposure to ANIT, BDECs produce a factor(s) that causes neutrophil chemotaxis and neutrophil-dependent hepatocellular injury. To test this hypothesis BDECs were isolated from male Sprague Dawley rats and incubated with ANIT (6.25, 12.5, 25, or 50 microM) or vehicle for 24 h. The conditioned medium (CM) was collected and placed in the bottom chamber of a two-chambered chemotaxis system, while isolated neutrophils were placed in the top chamber. Chemotaxis was indicated by neutrophil migration through a membrane to the bottom chamber. CM from BDECs exposed to each concentration of ANIT was chemotactic, whereas CM from vehicle-treated BDECs was not. ANIT alone caused a modest degree of chemotaxis at 50 microM. The conditioned media were added to isolated hepatocytes or to hepatocyte-neutrophil cocultures and incubated for 24 h. Hepatocyte toxicity was indicated by alanine aminotransferase release into the culture medium. CM from vehicle-treated BDECs did not cause hepatocyte killing in either hepatocyte-neutrophil cocultures or hepatocyte cultures. In contrast, the addition of CM from ANIT-treated BDECs (CM-BDEC-A) to hepatocyte-neutrophil cocultures resulted in hepatocyte killing. The same CM was not cytotoxic to hepatocyte cultures devoid of neutrophils. The hepatocyte killing could not be explained by residual ANIT in the CM, which was below the limit of detection (< or = 0.5 microM). The addition of antiproteases afforded protection against neutrophil-dependent hepatocellular injury induced by CM-BDEC-A. These results indicate that ANIT causes BDECs to release a factor(s) that attracts neutrophils and stimulates them to injure hepatocytes in vitro. (+info)
ANIT-induced disruption of biliary function in rat hepatocyte couplets. (2/67)alpha-Naphthylisothiocyanate (ANIT) induces intrahepatic cholestasis in rats, involving damage to biliary epithelial cells; our study aims to investigate whether disruption of biliary function in hepatocytes can contribute to early stages of ANIT-induced intrahepatic cholestasis. Isolated rat hepatocyte couplets were used to investigate biliary function in vitro by canalicular vacuolar accumulation (cVA) of a fluorescent bile acid analogue, cholyl-lysyl-fluorescein (CLF), within the canalicular vacuole between the two cells. After a 2-h exposure to ANIT, there was a concentration-dependent inhibition of cVA (cVA-IC50; 25 microM), but no cytotoxicity (LDH leakage or [ATP] decline) within this ANIT concentration range. There was no loss of cellular [GSH] at low ANIT concentrations, but, at 50 microM ANIT, a small but significant loss of [GSH] had occurred. Diethylmaleate (DEM) partially depleted cellular [GSH], but addition of 10 microM ANIT had no further effect on GSH depletion. Reduction in cVA was seen in DEM-treated cells; addition of ANIT to these cells reduced cVA further, but the magnitude of this further reduction was no greater than that caused by ANIT alone, indicating that glutathione depletion does not enhance the effect of ANIT. F-actin distribution (by phalloidin-FITC staining) showed an increased frequency of morphological change in the canalicular vacuoles but only a small, non-significant (0.05 < p < 0.1) increase in proportion of the F-actin in the region of the pericanalicular web. The results are in accord with a disruption of hepatocyte canalicular secretion within two h in vitro, at low, non-cytotoxic concentrations of ANIT, and the possible involvement of a thiocabamoyl-GSH conjugate of ANIT (GS-ANIT) in this effect. (+info)
High plasma cholesterol in drug-induced cholestasis is associated with enhanced hepatic cholesterol synthesis. (3/67)In alpha-naphthylisothiocyanate-treated mice, plasma phospholipid (PL) levels were elevated 10- and 13-fold at 48 and 168 h, respectively, whereas free cholesterol (FC) levels increased between 48 h (17-fold) and 168 h (39-fold). Nearly all of these lipids were localized to lipoprotein X-like particles in the low-density lipoprotein density range. The PL fatty acyl composition was indicative of biliary origin. Liver cholesterol and PL content were near normal at all time points. Hepatic hydroxymethylglutaryl CoA reductase activity was increased sixfold at 48 h, and cholesterol 7alpha-hydroxylase activity was decreased by approximately 70% between 24 and 72 h. These findings suggest a metabolic basis for the appearance of abnormal plasma lipoproteins during cholestasis. Initially, PL and bile acids appear in plasma where they serve to promote the efflux of cholesterol from hepatic cell membranes. Hepatic cholesterol synthesis is then likely stimulated in the response to the depletion of hepatic cell membranes of cholesterol. We speculate that the enhanced synthesis of cholesterol and impaired conversion to bile acids, particularly during the early phase of drug response, contribute to the accumulation of FC in the plasma. (+info)
Characterization of inducible nature of MRP3 in rat liver. (4/67)We found previously that expression of multidrug resistance-associated protein (MRP) 3 is induced in a mutant rat strain (Eisai hyperbilirubinemic rats) whose canalicular multispecific organic anion transporter (cMOAT/MRP2) function is hereditarily defective and in normal Sprague-Dawley (SD) rats after ligation of the common bile duct. In the present study, the inducible nature of MRP3 was examined, using Northern and Western blot analyses, in comparison with that of other secondary active [Na(+)-taurocholic acid cotransporting polypeptide (Ntcp), organic anion transporting polypeptide 1 (oatp1), and organic cation transporter (OCT1)] and primary active [P-glycoprotein (P-gp), cMOAT/MRP2, and MRP6] transporters. alpha-Naphthylisothiocyanate treatment and common bile duct ligation induced expression of P-gp and MRP3, whereas expression of Ntcp, oatp1, and OCT1 was reduced by the same treatment. Although expression of MRP3 was also induced by administration of phenobarbital, that of cMOAT/MRP2, MRP1, and MRP6 was not affected by any of these treatments. Moreover, the mRNA level of MRP3, but not that of P-gp, was increased in SD rats after administration of bilirubin and in Gunn rats whose hepatic bilirubin concentration is elevated because of a defect in the expression of UDP-glucuronosyl transferase. However, the MRP3 protein level was not affected by bilirubin administration. Although the increased MRP3 mRNA level was associated with the increased concentration of bilirubin and/or its glucuronides in mutant rats and in SD rats that had undergone common bile duct ligation or alpha-naphthylisothiocyanate treatment, we must assume that factor(s) other than these physiological substances are also involved in the increased protein level of MRP3. (+info)
Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats. (5/67)It has been a desire to develop orally effective therapeutic agents that restore the liver function in chronic injury. Here we demonstrated that trans-4-L-hydroxyprolyl-L-serine (JBP923) and cyclo-trans-4-L-hydroxyprolyl-L-serine (JBP485), which was previously isolated from hydrolysate of human placenta, exhibit potent antihepatitis activity after their oral administration. The increase in bilirubin concentration and activities of liver cytosolic enzymes in serum caused by alpha-naphthylisothiocyanate intoxication in rats were significantly countered both after i.v. and oral administration of these dipeptides, whereas glycyrrhizin, which has been used in the treatment of chronic hepatitis, is active only after its i.v. administration. Antihepatitis activity of dipeptides results, at least partially, from their direct effect on hepatocytes because glutamic-oxaloacetic transaminase and lactate dehydrogenase activities in the medium of hepatotoxin-exposed primary cultured hepatocytes were reduced by these compounds. When comparing the plasma concentration-time profile of JBP923 after its i.v., oral, and portal vein injection, it is suggested that JBP923 is almost completely absorbed from gastrointestinal lumen, and hepatic first-pass removal is minor. JBP923 inhibited the proton-dependent transport of glycylsarcosine in brush-border membrane vesicles, suggesting that peptide transport system(s) may recognize JBP923. Thus, these dipeptides are potent antihepatitis reagents that are still active after oral administration and may be useful for clinical applications. (+info)
Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. (6/67)The purpose of this study was to evaluate the feasibility of metabonomics technology for developing a rapid-throughput toxicity screen using 2 known hepatotoxicants: carbon tetrachloride (CCl(4)) and alpha-naphthylisothiocyanate (ANIT) and 2 known nephrotoxicants: 2-bromoethylamine (BEA) and 4-aminophenol (PAP). In addition, the diuretic furosemide (FURO) was also studied. Single doses of CCl(4) (0.1 and 0.5 ml/kg), ANIT (10 and 100 mg/kg), BEA (15 and 150 mg/kg), PAP (15 and 150 mg/kg) and FURO (1 and 5 mg) were administered as single IP or oral doses to groups of 4 male Wistar rats/dose. Twenty-four-h urine samples were collected pretest, daily through Day 4, and on Day 10 (high dose CCl(4) and BEA only). Blood samples were taken on Days 1, 2, and 4 or 1, 4, and 10 for clinical chemistry assessment, and the appropriate target organ was examined microscopically. NMR spectra of urine were acquired and the data processed and subjected to principal component analyses (PCA). The results demonstrated that the metabonomic approach could readily distinguish the onset and reversal of toxicity with good agreement between clinical chemistry and PCA data. In at least 2 instances (ANIT and BEA), PCA analysis suggested effects at low doses, which were not as evident by clinical chemistry or microscopic analysis. Furosemide, which had no effect at the doses employed, did not produce any changes in PCA patterns. These data support the contention that the metabonomic approach represents a promising new technology for the development of a rapid throughput in vivo toxicity screen. (+info)
Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein A-I transgenic rats is diminished through dose-dependent apolipoprotein A-I activation of LCAT. (7/67)Administration of alpha-naphthylisothiocyanate (ANIT) to rats induces changes to plasma lipids consistent with cholestasis. We have previously shown (J. Lipid Res. 37 (1996) 1086) that animals treated with ANIT accumulate large amounts of free cholesterol (FC) and phospholipid (PL)-rich cholestatic lipoproteins in the LDL density range by 48 h. This lipid was cleared by 120 h through apparent movement into HDL with concomitant cholesteryl ester (CE) production. It was hypothesised that the clearance was mediated through the movement of the PL and FC into apolipoprotein A-I (apo A-I) containing lipoproteins followed by LCAT esterification to form CE. To test this hypothesis, rats overexpressing various amounts of human apo A-I (TgR[HuAI] rats) were treated with ANIT (100 mg/kg) and the effect of plasma apo A-I concentration on plasma lipids and lipoprotein distribution was examined. In untreated TgR[HuAI] rats, human apo A-I levels were strongly correlated to plasma PL (r(2)=0. 94), FC (r(2)=0.93) and CE (r(2)=0.90), whereas in ANIT-treated TgR[HuAI] rats, human apo A-I levels were most strongly correlated to CE levels (r(2)=0.80) and an increased CE/FC ratio (r(2)=0.62) and the movement of cholestatic lipid in the LDL to HDL. Since LCAT activity was not affected by ANIT treatment, these results demonstrate that the ability of LCAT to esterify the plasma FC present in cholestatic liver disease is limited by in vivo apo A-I activation of the cholestatic lipid and not by the catalytic capacity of LCAT. (+info)
Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction. (8/67)The anatomical details of the biliary tree architecture of normal rats and rats in whom selective proliferation was induced by feeding alpha-naphthylisothiocyanate (ANIT) were reconstructed in three dimension using a microscopic-computed tomography scanner. The intrahepatic biliary tree was filled with a silicone polymer through the common bile duct and each liver lobe embedded in Bioplastic; specimens were then scanned by a microscopic-computed tomography scanner and modified Feldkamp cone beam backprojection algorithm applied to generate three-dimensional images. Quantitative analysis of bile duct geometry was performed using a customized software program. The diameter of the bile duct segments of normal and ANIT-fed rats progressively decreased with increasing length of the biliary tree. Diameter of bile ducts from ANIT-fed rats (range, 21 to 264 microm) was similar to that of normal rats (22 to 279 microm). In contrast, the number of bile duct segments along the major branch reproducibly doubled, the length of the bile duct segments decreased twofold, and the length of the biliary tree remained unchanged after ANIT feeding. Moreover, the total volume of the biliary tree of ANIT-fed rats was significantly greater (855 microl) than in normal rats (47 microl). Compared with normal rats, the total surface area of the biliary tree increased 26 times after ANIT-induced bile duct proliferation. Taken together, these observations quantitate the anatomical remodeling after selective cholangiocyte proliferation and strongly suggest that the proliferative process involves sprouting of new side branches. Our results may be relevant to the mechanisms by which ducts proliferate in response to hepatic injury and to the hypercholeresis that occurs after experimentally induced bile duct proliferation. (+info)
... is a chemical compound which is an isothiocyanate derivative of naphthalene. CID 11080 from PubChem. ...
List of MeSH codes (D02)
... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ... vitamin k 1 MeSH D02.806.550.750 --- vitamin k 2 MeSH D02.806.550.875 --- vitamin k 3 MeSH D02.845.746.703 --- ... 1-butanol MeSH D02.033.415.110.220 --- chlorobutanol MeSH D02.033.415.110.855 --- tert-butyl alcohol MeSH D02.033.415.220 --- ...
List of MeSH codes (D04)
... vitamin k 1 MeSH D04.615.638.721.374.844 --- vitamin k 2 MeSH D04.615.638.721.374.922 --- vitamin k 3 MeSH D04.615.638.845 --- ... 1-naphthylamine MeSH D04.615.638.845.800 --- sertraline MeSH D04.615.638.850 --- 2-naphthylamine MeSH D04.615.638.870 --- 1- ... naphthylisothiocyanate MeSH D04.615.638.900 --- naphthylvinylpyridine MeSH D04.615.638.930 --- pravastatin MeSH D04.615.638.945 ... 10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 --- methylcholanthrene MeSH D04.615.149.700 --- perylene MeSH D04.615. ...
Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 260 Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide ... Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V16 987 (1995) Cunningham, A. L., and J. V. Hurley. "Alpha‐ ... 1981., p. 1-2 NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases. U.S. Department of Health & Human Services, ... The usual method is the reaction of 1-naphthylamine hydrochloride with ammonium thiocyanate: [C10H7NH3]Cl + NH4SCN → C10H7NHC(S ...
Isothiocyanate Naphthyl isothiocyanate Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue ... CS1 maint: Multiple names: authors list (link) ; Collective Volume, 1, p. 447 U.S. Patent 4,211,867A. ...
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Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis | BMC Gastroenterology | Full Text
Cholestasis is characterized by impaired bile flow, reduction of bile acids in the intestine, and retention of bile acids in the liver. Rats taken in alpha naphthylisothiocyanate (ANIT) have been one of the most common experimental models of intrahepatic cholestasis and used extensively, which was permitted to describe not only cholestatic alterations but also compensatory mechanisms . The liver in ANIT-treated rats showed cholangiolitic hepatitis characterized by intrahepatic cholestasis, necrosis of hepatocytes and biliary epithelial cells and bile obstruction .. In current clinical practice, initial assessment of hepatobiliary diseases is accomplished by measuring serum concentrations of bile acids and bilirubin as well as serum activities of liver-associated enzymes which reveal information about the state of liver. Our previous study showed that the indexes of liver damage and pathological changes start to rise at 24h after ANIT treatment, reach a maximum at 48h and trend to restore ...
This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl4)-, D-galactosamine (GalN)- and α-naphthylisothiocyanate (ANIT)-induced liver injury. Acute hepatotoxicity was induced by intraperitoneal injection of CCl4 (10 μL/kg), GalN (700 mg/kg), and ANIT (40 mg/kg). Animals received MCR (30, 100, and 300 mg/kg ) orally at 48, 24, and 2 h before and 6 h after administration of CCl4, GalN, and ANIT. Serum activities of aminotransferase were significantly higher at 24 h after CCl4 or GalN treatment. These changes were attenuated by MCR. Histopathological analysis revealed multiple and extensive areas of portal inflammation, hepatocellular necrosis, and an increase in inflammatory cell infiltration. These changes were inhibited by MCR. Serum total bilirubin concentration increased and bile flow decreased significantly 48 h after ANIT treatment, which was attenuated by MCR. Our results suggest that MCR has a protective effect on ...
The aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) on the alpha-naphthylisothiocyanate (ANIT)-induced acute and recovery stage of cholestasis model mice. In the acute stage of model mice, pretreatment with UDCA (25, 50, and 100 mg·kg-1, ig) for 12 days prior to ANIT administration (50 mg·kg-1, ig) resulted in the dramatic increase in serum biochemistry, with aggrevation of bile infarcts and hepatocyte necrosis. The elevation of beta-muricholic acid (β-MCA), cholic acid (CA), and taurocholic acid (TCA) in serum and liver, and reduction of these bile acids (BAs) in bile was observed ...
Dr. Anit Patel, MD is a Critical Care Medicine Specialist in Fairfield, CA. Search for higher rated doctors in this area on Healthgrades.
Hello, have just had laptop cleared and cleaned of some worm, trojans and pop ups. Have installed avg anit virus and anti spy ware but I am having...
Melittin inhibits cholangiocyte proliferation in DDC-fed mice. Immunofluorescence staining shows co-localization of PCNA staining with CK-7 (arrow head) followi
by TimH , Jun 22, 2015. According to current estimates, more than 300,000 patients-mostly people aged 65 and older-sustain a hip fracture each year in the United States, and the annual incidence is expected to exceed 500,000 by 2040. Hip fractures often result in nursing home stays, higher mortality, and lower quality of life. The expected rising incidence will place a significant financial burden on patients, families, insurers, and other key stakeholders. Surgery is the primary treatment strategy for hip fractures because it can reduce mortality risk and improve physical function, but less is known about the societal cost implications of hip fractures. New Data Little is known about the return on investment of surgery for hip fracture patients, says Lane Koenig, PhD. "Policymakers and payers are increasingly focusing on value, making it critical to understand the return from healthcare spending," he says. To investigate this further, Dr. Koenig and colleagues conducted a study-published in ...
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. - Semantic...
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and represses genes involved in bile acid biosynthesis. We investigated whether the synthetic FXR agonist GW4064 could protect against cholestatic liver damage in rat models of extrahepatic and intrahepatic cholestasis. In the bile duct-ligation and alpha-naphthylisothiocyanate models of cholestasis, GW4064 treatment resulted in significant reductions in serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase, as well as other markers of liver damage. Rats that received GW4064 treatment also had decreased incidence and extent of necrosis, decreased inflammatory cell infiltration, and decreased bile duct proliferation. Analysis
We saw no signs of fortification beyond this polnt, ex- acept here and there a (light stone-wall, such as I have already described. Perhaps my description may have conveyed the Ilea that the Mormon defences were really formidable. Belter natural positions far mil Itary. works could scarcely be found anywhere, b-i good as they aie, they afford few of the opportunitic for hurling rocks upon the columns of passing troop of which so much has been said. A traveling com panlon and your correspondent, wllh fin.a. 1 ibor clambered up Ihe cliffs on the north aide of the Canon, and Imd the experiment of rolling down some of the loose rocks frrtm a ledge jinrhaps H thousand leet above the road. We four,d a conglomerated mass of sainl, sloiie anit pebbles, poised upon the edge uf a ledge in such a position that our nulled strength W:IK fciifficlent lo lopple It over the brink. Away rolled the mass, crashing through the cedars, dashing upon a cliff btlow, ard flying Into a thousand pieces, bu scarce a ...
TY - JOUR. T1 - Phenytoin liver glutathione depletion. A possible mechanism of liver injury. AU - Snodgrass, W. R.. AU - Whitfield, S.. PY - 1981. Y1 - 1981. N2 - Phenytoin produces significant liver glutathione depletion in vivo in mice. Pretreatment with inducers and inhibitors of drug metabolism show enhancement of phenytoin-induced glutathione depletion following phenobarbital and 3-methylcholanthrene pretreatment, inhibition of glutathione depletion following piperonyl butoxide, cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of glutathione depletion following butylated hydroxytoluene pretreatment (both inducers of epoxide hydrolase). These data suggest that phenytoin-induced liver glutathione depletion may occur via a reactive metabolite and that this reactive metabolite possibly may be an epoxide.. AB - Phenytoin produces significant liver glutathione depletion in vivo in mice. Pretreatment with inducers and inhibitors of ...
definition of SCIH, what does SCIH mean?, meaning of SCIH, Sickle Cell Intrahepatic Cholestasis, SCIH stands for Sickle Cell Intrahepatic Cholestasis
Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disorder. Maternal effects of ICP are mild; however, there is a clear association between ICP and higher frequency of fetal distress, preterm delivery, and sudden
... Some people have basic questions about how pregnancy happens. Some may have questions about avoiding a pregnancy
Unscramble cholestasis | Words unscrambled from letters cholestasis | Scrabble Word cholestasis | Words Made with the Letters...
Unscramble cholestasis, Unscramble letters cholestasis, Point value for cholestasis, Word Decoder for cholestasis, Word generator using the letters cholestasis, Word Solver cholestasis, Possible Scrabble words with cholestasis, Anagram of cholestasis
Because T21 diagnosis wasn't enough - Intrahepatic Cholestasis of Pregnancy | Forums | What to Expect
27 week appt yesterday and on top of out Trisomy 21 diagnosis I now gave cholestasis which means she will be delivered at 37 weeks to avoid possible complications. My poor baby girl. Even more so because of the DS diagnosis I just wanted her to stay cozy as long as possible
ANA MARIA KESE(1), VIOLETA COMaNESCU(2), MARIA COMaNESCU(2), CRISTIANA SIMIONESCU(3), DENISA ENESCU-BIERU(1) (1) Sport and Physical Education Faculty, University of Craiova; (2) Laboratory of Pathology, Emergency County Hospital Craiova; (3) Department of Pathology, University of Medicine and Pharmacy of Craiova ABSTRACT This study included 116 cases of liver serologically confirmed biopsies, which were clinico-pathologicaly assesed. We
Participation of cholestatic factor in the pathogenesis of intrahepatic cholestasis in acute viral hepatitis. | CureHunter
Participation of cholestatic factor in the pathogenesis of intrahepatic cholestasis in acute viral hepatitis. - Y Mizoguchi, Y Sakagami, H Tsutsui, T Monna, S Yamamoto, S Morisawa
Find out about itching during pregnancy, including causes, ways to ease itching, and when you need to seek medical attention fast for possible intrahepatic cholestasis of pregnancy (ICP), also called obstetric cholestasis.
Mutations in human and/or mouse homologs are associated with this disease. Synonyms: intrahepatic cholestasis of pregnancy
While oxidative stress is a commonly cited toxicological mechanism, conventional methods to study it suffer from a number of shortcomings, including destruction of the sample, introduction of potential artifacts, and a lack of specificity for the reactive species involved. Thus, there is a current need in the field of toxicology for non-destructive, sensitive, and specific methods that can be used to observe and quantify intracellular redox perturbations, more commonly referred to as oxidative stress. Here, we present a method for the use of two genetically-encoded fluorogenic sensors, roGFP2 and HyPer, to be used in live-cell imaging studies to observe xenobiotic-induced oxidative responses ...
This is my second pregnancy. I had ICP with my last and delivered at 36 weeks. At that time it took approximately 2 weeks to get a diagnosis. I...
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Objective : To determine the risk of adverse pregnancy outcomes resulting from intrahepatic cholestasis. Methods : We analyzed 91 women with singleton pregnancies complicated by cholestasis who gave birth at Kuopio University Hospital from January 1990 to December 1996. Logistic regression analysis was used to compare pregnancy outcomes of this...
Intrahepatic Cholestasis of Pregnancy Causes Severe Itching, Increases Risk of Premature, Still Born Baby [VIDEO]
Christina DePino thought the severe itching she felt was a normal symptom of pregnancy. Luckily she had gone to a checkup before things turned for the worse as she found out she could have given birth to a premature or stillborn baby and then shares awareness of cholestasis of pregnancy causes.
The Enigma of Intrahepatic Cholestasis of Pregnancy: Lessons from Chile - Reyes - 1982 - Hepatology - Wiley Online Library
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This may be due to the low percentage of biliary epithelial cells in the liver or a lack of suitable model for cell...
n of your full length CFTR cDNA. To investigate if any portion of the CFTR cDNA was being unintentionally expressed as a result of the presence of a cryptic
機能性RNAの変遷を通して, siRNAによる肝疾患治療システムの現状と展望を考える To consider an overview and prospect of therapy to hepatocellular injuries by using siRNA through history to the function of non-coading RNAs ...
A prospective study was undertaken to evaluate fat malabsorption during intrahepatic cholestasis of pregnancy (ICP), a disease characterized by a mild cholestasis of short duration appearing in otherwise healthy young women. An abnormal fecal fat exc
By definition, cholestasis is any condition in which the flow of bile - a digestive fluid - from the liver is blocked. Extrahepatic cholestasis occurs outside the liver. Intrahepatic cholestasis occurs inside the liver. Pregnancy is one of many possible causes of intrahepatic cholestasis. Other names for cholestasis of pregnancy include obstetric cholestasis and intrahepatic cholestasis of pregnancy.. Other than intense itching, cholestasis of pregnancy poses few problems for mothers. Cholestasis of pregnancy can be dangerous for a developing baby, however. Early delivery is usually recommended.. Symptoms. Signs and symptoms of cholestasis of pregnancy may include:. ...
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Molecules | Free Full-Text | Repeated Oral Administration of Oleanolic Acid Produces Cholestatic Liver Injury in Mice | Notes
Oleanolic acid (OA) is a triterpenoid and a fantastic molecule with many beneficial effects. However, high-doses and long-term use can produce adverse effects. This study aimed to characterize the hepatotoxic potential of OA. Mice were given OA at doses of 100-3,000 µmol/kg (45-1,350 mg/kg), po for 10 days, and the hepatotoxicity was determined by serum biochemistry, histopathology, and toxicity-related gene expression via real-time RT-PCR. Animal body weight loss was evident at OA doses of 1,000 µmol/kg and above. Serum alanine aminotransferase activities were increased in a dose-dependent manner, indicative of hepatotoxicity. Serum total bilirubin concentrations were increased, indicative of cholestasis. OA administration produced dose-dependent pathological lesions to the liver, including inflammation, hepatocellular apoptosis, necrosis, and feathery degeneration indicative of cholestasis. These lesions were evident at OA doses of 500 µmol/kg and above. Real-time RT-PCR revealed that OA produced
Intrahepatic cholestasis of pregnancy: Diagnosis and management; A survey of Royal Australian and New Zealand College of...
Background Intrahepatic cholestasis of pregnancy (ICP) is an uncommon obstetric condition characterised by intense maternal pruritis and biochemical abnormality. There is a degree of contention regarding the diagnosis and management of ICP, and currently, there are no nationally accepted guidelines. Aims To conduct a survey of Fellows and Members of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) regarding their diagnosis and management ICP. Methods An online survey of currently practising RANZCOG Fellows and Members, utilising Survey Monkey. Results Thirty percent of those sent the survey responded, comprising approximately 40% of practising obstetricians. Fasting bile acid and serum transaminase elevation in association with the characteristic itch define the disease process for the majority of respondents and also inform management decisions. There was no critical level of bile acid elevation that mandated treatment for the majority of respondents. ...
Citation: Caperna, T.J., Blomberg, L., Garrett, W.M., Talbot, N.C. 2011. Culture of porcine hepatocytes or bile duct epithelial cells by inductive serum-free media. In Vitro Cellular and Developmental Biology - Animals. 47(3):218-233. Interpretive Summary: The study presents a method for the selective in vitro culture, i.e., "in the petri dish," of pig hepatocytes and bile duct cells, i.e., liver cells. The report characterizes the cells general health and typrical in vivo-like, i.e., "in the body-like," appearance and functions. Also, presented are data on specific liver gene expression and liver serum-protein production that again show that the hepatocytes and bile duct cell cultures are similar to liver cells found in a pigs own liver. For agricultural purposes, because the liver is so important to the growth and maintenance of the pig, this in vitro model could be useful for testing man-made genetic changes to the liver function of pigs prior to the actual genetic engineering of the pig, ...
Find the best cholestasis doctors in Delhi NCR. Get guidance from medical experts to select cholestasis specialist in Delhi NCR from trusted hospitals - credihealth.com
Has anyone experienced intraheptic Cholestasis before ? I have an extreme itch that I cannot get to go away . No amount of itching or lotion or anything is helping . Ive been reading stories on the internet (I know , bad idea) about this and they all result in still birth . I have an appointment tomorrow but has anyone who has experienced this tell me differences between this and a regular itch ? I feel like crying because I cant stop itching
Erm your midwife sound stupid If needs be i would make an appointment ASAP with your GP just to rule anything more serious out Are you itching anywhere eles? if not that could be your deoderant but
1-naphthyl isothiocyanate - Substance Information - ECHA
1-naphthyl isothiocyanate. ↓Other names: Regulatory process names  IUPAC names  ... Ss - Skin sensitiser (i.e. classified in skin sensitisation categories 1, 1A or 1B). More information about skin sensitiser ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ... Sr - Respiratory sensitiser (i.e. classified in respiratory sensitisation categories 1, 1A or 1B). More information about ...https://echa.europa.eu/substance-information/-/substanceinfo/100.008.174
Find quality suppliers and manufacturers of 1-Naphthyl isothiocyanatefor price inquiry.where to buy 1-Naphthyl isothiocyanate. ... Also offer free database of 1-Naphthyl isothiocyanate including MSDS sheet(poisoning, toxicity, hazards and safety),chemical ... a-Naphthyl isothiocyanate. 1-Naphthyl isothiocyanate Chemical Properties. Product Name: Isothiocyanic acid-1-naphthyl ester ( ... 1-Naphthyl isothiocyanate Toxicity Data With Reference. 1.. mmo-sat 100 µg/plate ABCHA6 44,3017,80 ...http://www.lookchem.com/1-Naphthyl-isothiocyanate/
What rhymes with 1-naphthylisothiocyanate?
... Lookup it up at Rhymes.net - the most comprehensive rhyming words dictionary on the ... Discuss this 1-naphthylisothiocyanate rhyme with the community:. Citation. Use the citation below to add this rhymes to your ... Weve got 0 rhyming words for 1-naphthylisothiocyanate ». What rhymes with 1-naphthylisothiocyanate?. This page is about the ... We couldnt find any rhymes for the word 1-naphthylisothiocyanate.. Maybe you were looking for one of these terms?. *twirled, - ...http://www.rhymes.net/rhyme/1-naphthylisothiocyanate
1-Naphthyl isothiocyanate - Wikipedia
1-Naphthyl isothiocyanate is a chemical compound which is an isothiocyanate derivative of naphthalene. CID 11080 from PubChem. ...https://en.wikipedia.org/wiki/1-Naphthyl_isothiocyanate
NIM1K (NIM1 serine/threonine protein kinase) - Rat Genome Database
Orthologs 1. Mus musculus (house mouse):. Nim1k (NIM1 serine/threonine protein kinase). HGNC. EggNOG, Ensembl, HGNC, HomoloGene ... 1,2-dimethylhydrazine multiple interactions. ISO. RGD:1308116. 6480464. [APC protein affects the susceptibility to 1, 2- ... 1.. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations. ... PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). HGNC. Inparanoid. Sus scrofa (pig):. PRKAA2 (protein kinase ...https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1604515
Phenytoin liver glutathione depletion. A possible mechanism of liver injury<...
... cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of ... cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of ... cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of ... cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of ...https://researchexperts.utmb.edu/en/publications/phenytoin-liver-glutathione-depletion-a-possible-mechanism-of-liv
Systems level analysis and identification of pathways and networks associated with liver fibrosis. - PubMed - NCBI
AbdulHameed MD1, Tawa GJ1, Kumar K1, Ippolito DL2, Lewis JA2, Stallings JD2, Wallqvist A1. ... B) Activation at 1 day of exposure. The mapped expression profile is the average log2 ratio in 1-naphthyl isothiocyanate 30 mg/ ... The mapped expression profile is the average log2 ratio in 1-naphthyl isothiocyanate 30 mg/kg and 60 mg/kg, at 0.25-day ... The mapped expression profile is the average log2 ratio in 1-naphthyl isothiocyanate 30 mg/kg and 60 mg/kg, and 4,4- ...https://www.ncbi.nlm.nih.gov/pubmed/25380136
List of MeSH codes (D02) - Wikipedia
... vitamin k 1 MeSH D02.455.849.291.523.500.844 --- vitamin k 2 MeSH D02.455.849.291.523.500.922 --- vitamin k 3 MeSH D02.455. ... 3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH D02.092.146.325 --- p-dimethylaminoazobenzene MeSH ... vitamin k 1 MeSH D02.806.550.750 --- vitamin k 2 MeSH D02.806.550.875 --- vitamin k 3 MeSH D02.845.746.703 --- ... 1-butanol MeSH D02.033.415.110.220 --- chlorobutanol MeSH D02.033.415.110.855 --- tert-butyl alcohol MeSH D02.033.415.220 --- ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
Haz-Map Agent Category
Haz-Map is an occupational health and toxicology database designed to link jobs to hazardous job tasks that are linked to occupational diseases and their symptoms. It is a relational database of chemicals, jobs and diseases.https://hazmap.nlm.nih.gov/agent-category?level=2&agent_category_id=8&agent_subparent_category_name=Isothiocyanates
A New Method for Sampling and Analysis of Atmospheric Ammonia and Amines - Ambient Air Quality Testing and Stack Emissions...
A method has been developed in which atmospheric ammonia and amines can be simultaneously collected and derivatized using 1- ... Naphthylisothiocyanate to their corresponding thioureas, which are then analyzed using HPLC with UV detection. Samples are ...https://www.aaclab.com/about-aac/publications-presentations/new-atmospheric-ammonia-sampling-method.html
1 - Accurate day trading system
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Alpha-Naphthyl Isothiocyanate (1) Liver Diseases (1) Liquid Chromatography (1) Interleukin-6 (1) Lipids (1) Liver (1) Mice, ... Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury by Fang, Zhong-Ze ... Lu, Dan (1) Du, Zuo (1) Gonzalez, Frank J (1) Gao, Peng (1) Tanaka, Naoki (1) Fang, Zhong-Ze (1) Sun, H.-Z. (1) Yao, Zhi (1) ... Peer reviewed (1) Author. Zhu, Zhi-Tu (1) Sun, Hong-Zhi (1) Zhang, Wei-Hua (1) more .... Jiang, Chang-Tao (1) Zhang, Chunze (1 ...https://beluga.sub.uni-hamburg.de/vufind/Primo/Search?lookfor=Gao%2C+Cai-yan+&type=Author&filter%5B%5D=rtype%3A%22Articles%22&filter%5B%5D=creator%3A%22Cai%2C+Y%22&filter%5B%5D=creationdate%3A%22%5B2017+TO+2017%5D%22&filter%5B%5D=topic%3A%22Nf-%CE%9Ab%2FIl-6%2FStat3+Axis%22&dfApplied=1
Hepatomegaly - Diseases | CTD
Inferred via 1 gene: CYP1B1 450. 9.. positive regulation of apoptotic process Hepatomegaly Inferred via 83 chemicals: 1,3- ... Inferred via 1 gene: CYBA 411. 14.. regulation of mitochondrial membrane potential Hepatomegaly Inferred via 78 chemicals: 1,2- ... Inferred via 1 gene: AHR 306. 25.. regulation of blood pressure Hepatomegaly Inferred via 59 chemicals: Acetaminophen , ... Inferred via 1 gene: TGFB1 195. 44.. triglyceride homeostasis Hepatomegaly Inferred via 35 chemicals: 1,3-dichloro-2-propanol ...http://ctdbase.org/detail.go?type=disease&acc=MESH%3AD006529&view=phenotype
Glycol Ether Solvents Exporter, Manufacturer, Distributor, Supplier, Trading Company, Glycol Ether Solvents India
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Animal Diseases - Diseases | CTD
Inferred via 1 gene: RFC4 322. 21.. cell cycle Disease Models, Animal Inferred via 46 chemicals: 4-. (N-. methyl-. N- ... Inferred via 1 gene: TNF 316. 24.. protein oxidation Disease Models, Animal Inferred via 41 chemicals: 1-. Methyl-. 4-. phenyl- ... Inferred via 1 gene: SNCA 190. 37.. detection of oxidative stress Disease Models, Animal Inferred via 33 chemicals: 1-. Methyl- ... Inferred via 1 gene: P2RX7 824. 4.. positive regulation of cell death Disease Models, Animal Inferred via 76 chemicals: 1- ...http://ctdbase.org/detail.go?type=disease&acc=MESH%3AD000820&view=phenotype
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Table of Contents - April 01, 2014, 349 (1) | Journal of Pharmacology and Experimental Therapeutics
All-Trans-Retinoic Acid Improves Cholestasis in α-Naphthylisothiocyanate-Treated Rats and Mdr2−/− Mice Shi-Ying Cai, Albert ... Paradoxical Effects on Force Generation after Efficient β1-Adrenoceptor Knockdown in Reconstituted Heart Tissue Christiane ... Pharmacological Evaluation of Adipose Dysfunction via 11β-Hydroxysteroid Dehydrogenase Type 1 in the Development of Diabetes in ... Correction to "G Protein-Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a KCa1.1 (BKCa)- ...http://jpet.aspetjournals.org/content/349/1
Alpha-Naphthylisothiocyanate triggering G2/M phase arrest and apoptosis in human brain malignant glioma U87MG cells via...
Alpha-Naphthylisothiocyanate triggering G2/M phase arrest and apoptosis in human brain malignant glioma U87MG cells via ... "Alpha-Naphthylisothiocyanate Triggering G2/M Phase Arrest and Apoptosis in Human Brain Malignant Glioma U87MG Cells via ... Keywords: Alpha-naphthyl isothiocyanate, Apoptosis, Brain malignant glioma, G2/M phase, Mitochondria, U87MG cell ... Apaf-1, AIF, Endo G and the stimulated caspase-9 and -3 activity. ...https://www.banglajol.info/index.php/BJP/article/view/21096
Experimental liver fibrosis research: update on animal models, legal issues and translational aspects | Fibrogenesis & Tissue...
Early changes in bile duct lining cells and hepatocytes in rats treated with α-naphthylisothiocyanate. Toxicol Appl Pharmacol. ... 2010, 1: 373-378.PubMed CentralPubMedView ArticleGoogle Scholar. *. Verna L, Whysner J, Williams GM: N-nitrosodiethylamine ... 1985, 1: 489-499.PubMedView ArticleGoogle Scholar. *. Kitamura K, Nakamoto Y, Akiyama M, Fujii C, Kondo T, Kobayashi K, Kaneko ... 2007, 22 (Suppl 1): S45-S48.PubMedView ArticleGoogle Scholar. *. Pessayre D, Berson A, Fromenty B, Mansouri A: Mitochondria in ...https://fibrogenesis.biomedcentral.com/articles/10.1186/1755-1536-6-19
Search Articles | University of Toronto Libraries
Collection Dvlpmt (Acquisitions) - Closed Orders (1) 1 Filter by. Remove filter. Collection Dvlpmt (Acquisitions) - Vendor ... 1. Full Text EASL Clinical Practice Guidelines: Management of cholestatic liver diseases ... Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2016, Volume 56, Issue 1, pp. 605 - 626 ... 1-Naphthylisothiocyanate , Cholestasis - pathology , Serotonin - blood , Animals , Liver - drug effects , Liver Cirrhosis - ...https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Drug-induced%20cholestatic%20liver%20disease
Artificial Neural Networks for Classification in Metabolomic Studies of Whole Cells Using 1H Nuclear Magnetic Resonance
... α-naphthylisothiocyanate," Biochemical Pharmacology, vol. 64, no. 1, pp. 67-77, 2002. View at Publisher · View at Google ... 1. and C. 13. HR-MAS spectroscopy of intact biopsy samples ex vivo and in vivo H. 1. MRS study of human high grade gliomas," ... 1. - and B. 1. -insensitive water-suppression method for in vivo localized H. 1. NMR spectroscopy," Journal of Magnetic ... D. F. Brougham,1,2 G. Ivanova,1,3 M. Gottschalk,1 D. M. Collins,1 A. J. Eustace,1 R. OConnor,1,4 and J. Havel5 ...https://www.hindawi.com/journals/bmri/2011/158094/ref/
Effects of alpha-naphthyl isothiocyanate and a heterocyclic am...
Effects of alpha-naphthyl isothiocyanate and a heterocyclic amine, PhIP, on cytochrome P-450, mutagenic activation of various ... To elucidate the mechanism underlying suppression by alpha-naphthyl isothiocyanate (ANIT) of mammary carcinogenesis induced by ... 1 Pages. 15-22 Identifiers. PMID: 15598703 Source. Medline License. Unknown Abstract. ... 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), we evaluated hepatic levels of cytochrome P-450 (CYP) enzymes, ...https://www.mysciencework.com/publication/show/effects-alpha-naphthyl-isothiocyanate-heterocyclic-amine-phip-cytochrome-p-450-mutagenic-activation-various-carcinogens-206911fb
Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes
Y. Ding, L. Zhao, H. Mei et al., "Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via ... D. L. Eizirik, M. L. Colli, and F. Ortis, "The role of inflammation in insulitis and Β-cell loss in type 1 diabetes," Nature ... U. Christen, "Chemokines as drug targets in type 1 diabetes," Endocrine, Metabolic and Immune Disorders-Drug Targets, vol. 7, ... 1, no. 9, pp. 1241-1264, 2004. View at Publisher · View at Google Scholar · View at Scopus ...https://www.hindawi.com/journals/ecam/2015/357357/
Derivatization reactions applicable to pesticide determination by high-performance liquid chromatography - Download PDF
Journal of Chromatography B Biomedical Applications 659(1-2): 243-257. The literature dealing with HPLC analytical methods for ... Copyright © 2018 EurekaMag.com · All Rights Reserved · 浟ICP夏10204677叻-1 Privacy · Disclaimer · Terms · Contact · DMCA/Copyright ... extraction for the determination of biogenic amines in fruit juices and alcoholic beverages after derivatization with 1- ... naphthylisothiocyanate and high performance liquid chromatography. A new method for determining biogenic amines in fruit juices ...https://eurekamag.com/research/002/590/002590620.php
CiNii Articles - 矢田 登
... naphthylisothiocyanate. （1985） ... Articles in CiNii:1. * Role of acetone bodies in the abnormal ... Articles in CiNii:1. * Studies on Absorption of Drugs. IV. Effects of Surface Active Agents on Intestinal Absorption of Drugs （ ... Articles in CiNii:1. * Effect of 2,4-dinitrophenol on transport of cefmetazole and diclofenac from thigh muscle tissue and from ... Articles in CiNii:1. * Comparison of the effects of sesame oil and oleic acid as suspension vehicles on gastrointestinal ...https://ci.nii.ac.jp/author?q=%E7%9F%A2%E7%94%B0+%E7%99%BB
- Western blot analysis and colorimetric assays also displayed that ANIT caused a time-dependent increase in cytosolic cytochrome c , pro-caspase-9, Apaf-1, AIF, Endo G and the stimulated caspase-9 and -3 activity. (banglajol.info)
- To elucidate the mechanism underlying suppression by alpha-naphthyl isothiocyanate (ANIT) of mammary carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), we evaluated hepatic levels of cytochrome P-450 (CYP) enzymes, mutagenic activation of environmental carcinogens and UDP-glucuronyltransferase (UDPGT) activities in female Sprague-Dawley rats fed a high fat diet. (mysciencework.com)
- OBJECTIVE:To investigate the therapeutic mechanism of compound Yindan decoction (CYD) in a rat model of acute intrahepatic cholestatic (AIC).METHODS:A total of 108 adult male rats were randomly divided into control (n =18) and AIC groups (n =90).AIC was induced in rats using alpha-naphthylisothiocyanate (ANIT)(75 mg/kg,10 mL/kg in corn oil,p.o. (cqvip.com)
- 1-Naphthyl isothiocyanate is a chemical compound which is an isothiocyanate derivative of naphthalene. (wikipedia.org)
- In- sert: Close-up of channels fact, 1-naphthyl-isothiocyanate (NITC) increased the accu- mulation of daunomycin (DNM) and vinblastine (VBL) significantly in both resis- tant cell lines. (forexwalkthrough.com)
- Pretreatment with inducers and inhibitors of drug metabolism show enhancement of phenytoin-induced glutathione depletion following phenobarbital and 3-methylcholanthrene pretreatment, inhibition of glutathione depletion following piperonyl butoxide, cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of glutathione depletion following butylated hydroxytoluene pretreatment (both inducers of epoxide hydrolase). (utmb.edu)
- We identified a PPI network module associated with liver fibrosis that includes known liver fibrosis-relevant genes, such as tissue inhibitor of metalloproteinase-1, galectin-3, connective tissue growth factor, and lipocalin-2. (nih.gov)
- 【Abstract】： Cholestatic liver disease is one of the common diseases in children aged ＜1 year and has a complex etiology and different outcomes. (lcgdbzz.org)
- 1. The biliary excretion of total bilirubin and bile acids, and the fate of tracer doses of radioactive sulphated and non-sulphated bile acids, were studied in patients with percutaneous transhepatic bile drainage. (portlandpress.com)
- The biliary excretion of radioactive labelled sulphated bile acids is low for at least 1 week after biliary drainage, but later becomes the predominant route for excretion in the anicteric patient. (portlandpress.com)