A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.
Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.
Organic compounds with the general formula R-NCS.
A class of organic compounds that contains a naphthalene moiety linked to a sulfonic acid salt or ester.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
Organic derivatives of thiocyanic acid which contain the general formula R-SCN.
Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.
Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The common orally transmitted traditions, myths, festivals, songs, superstitions, and stories of all peoples.
The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)
The use of mental images produced by the imagination as a form of psychotherapy. It can be classified by the modality of its content: visual, verbal, auditory, olfactory, tactile, gustatory, or kinesthetic. Common themes derive from nature imagery (e.g., forests and mountains), water imagery (e.g., brooks and oceans), travel imagery, etc. Imagery is used in the treatment of mental disorders and in helping patients cope with other diseases. Imagery often forms a part of HYPNOSIS, of AUTOGENIC TRAINING, of RELAXATION TECHNIQUES, and of BEHAVIOR THERAPY. (From Encyclopedia of Human Behavior, vol. 4, pp29-30, 1994)
The only genus in the family Oryziinae, order BELONIFORMES. Oryzias are egg-layers; other fish of the same order are livebearers. Oryzias are used extensively in testing carcinogens.
A suborder of nematodes characterized by larvae lacking cephalic hooks and a tail that is generally long and pointed.
Animals and plants which have, as their normal mode of reproduction, both male and female sex organs in the same individual.
A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
Development of female secondary SEX CHARACTERISTICS in the MALE. It is due to the effects of estrogenic metabolites of precursors from endogenous or exogenous sources, such as ADRENAL GLANDS or therapeutic drugs.
Proteins obtained from species of fish (FISHES).
A class of annelid worms with few setae per segment. It includes the earthworms such as Lumbricus and Eisenia.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
A bile pigment that is a degradation product of HEME.
Fleshy and reddish outgrowth of skin tissue found on top of the head, attached to the sides of the head, and hanging from the mandible of birds such as turkeys and chickens.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
A plant genus of the family ASTERACEAE. Oil from the seed (SAFFLOWER OIL) is an important food oil of commerce.
A plant genus of the family GENTIANACEAE. It is a source of swertiapuniside and IRIDOID GLYCOSIDES.
A system of traditional medicine which is based on the beliefs and practices of the Tibetan culture.
A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.
An autonomous region located in central Asia, within China.
Pathological processes of the LIVER.
A plant genus of the family ASTERACEAE.

Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro. (1/67)

The acute hepatotoxicity induced by alpha-naphthylisothiocyanate (ANIT) in rats is manifested as neutrophil-dependent necrosis of bile duct epithelial cells (BDECs) and hepatic parenchymal cells. This hepatotoxicity mirrors that of drug-induced cholangiolitic hepatitis in humans. Since BDECs are primary targets of ANIT-induced toxicity, we hypothesized that after exposure to ANIT, BDECs produce a factor(s) that causes neutrophil chemotaxis and neutrophil-dependent hepatocellular injury. To test this hypothesis BDECs were isolated from male Sprague Dawley rats and incubated with ANIT (6.25, 12.5, 25, or 50 microM) or vehicle for 24 h. The conditioned medium (CM) was collected and placed in the bottom chamber of a two-chambered chemotaxis system, while isolated neutrophils were placed in the top chamber. Chemotaxis was indicated by neutrophil migration through a membrane to the bottom chamber. CM from BDECs exposed to each concentration of ANIT was chemotactic, whereas CM from vehicle-treated BDECs was not. ANIT alone caused a modest degree of chemotaxis at 50 microM. The conditioned media were added to isolated hepatocytes or to hepatocyte-neutrophil cocultures and incubated for 24 h. Hepatocyte toxicity was indicated by alanine aminotransferase release into the culture medium. CM from vehicle-treated BDECs did not cause hepatocyte killing in either hepatocyte-neutrophil cocultures or hepatocyte cultures. In contrast, the addition of CM from ANIT-treated BDECs (CM-BDEC-A) to hepatocyte-neutrophil cocultures resulted in hepatocyte killing. The same CM was not cytotoxic to hepatocyte cultures devoid of neutrophils. The hepatocyte killing could not be explained by residual ANIT in the CM, which was below the limit of detection (< or = 0.5 microM). The addition of antiproteases afforded protection against neutrophil-dependent hepatocellular injury induced by CM-BDEC-A. These results indicate that ANIT causes BDECs to release a factor(s) that attracts neutrophils and stimulates them to injure hepatocytes in vitro.  (+info)

ANIT-induced disruption of biliary function in rat hepatocyte couplets. (2/67)

alpha-Naphthylisothiocyanate (ANIT) induces intrahepatic cholestasis in rats, involving damage to biliary epithelial cells; our study aims to investigate whether disruption of biliary function in hepatocytes can contribute to early stages of ANIT-induced intrahepatic cholestasis. Isolated rat hepatocyte couplets were used to investigate biliary function in vitro by canalicular vacuolar accumulation (cVA) of a fluorescent bile acid analogue, cholyl-lysyl-fluorescein (CLF), within the canalicular vacuole between the two cells. After a 2-h exposure to ANIT, there was a concentration-dependent inhibition of cVA (cVA-IC50; 25 microM), but no cytotoxicity (LDH leakage or [ATP] decline) within this ANIT concentration range. There was no loss of cellular [GSH] at low ANIT concentrations, but, at 50 microM ANIT, a small but significant loss of [GSH] had occurred. Diethylmaleate (DEM) partially depleted cellular [GSH], but addition of 10 microM ANIT had no further effect on GSH depletion. Reduction in cVA was seen in DEM-treated cells; addition of ANIT to these cells reduced cVA further, but the magnitude of this further reduction was no greater than that caused by ANIT alone, indicating that glutathione depletion does not enhance the effect of ANIT. F-actin distribution (by phalloidin-FITC staining) showed an increased frequency of morphological change in the canalicular vacuoles but only a small, non-significant (0.05 < p < 0.1) increase in proportion of the F-actin in the region of the pericanalicular web. The results are in accord with a disruption of hepatocyte canalicular secretion within two h in vitro, at low, non-cytotoxic concentrations of ANIT, and the possible involvement of a thiocabamoyl-GSH conjugate of ANIT (GS-ANIT) in this effect.  (+info)

High plasma cholesterol in drug-induced cholestasis is associated with enhanced hepatic cholesterol synthesis. (3/67)

In alpha-naphthylisothiocyanate-treated mice, plasma phospholipid (PL) levels were elevated 10- and 13-fold at 48 and 168 h, respectively, whereas free cholesterol (FC) levels increased between 48 h (17-fold) and 168 h (39-fold). Nearly all of these lipids were localized to lipoprotein X-like particles in the low-density lipoprotein density range. The PL fatty acyl composition was indicative of biliary origin. Liver cholesterol and PL content were near normal at all time points. Hepatic hydroxymethylglutaryl CoA reductase activity was increased sixfold at 48 h, and cholesterol 7alpha-hydroxylase activity was decreased by approximately 70% between 24 and 72 h. These findings suggest a metabolic basis for the appearance of abnormal plasma lipoproteins during cholestasis. Initially, PL and bile acids appear in plasma where they serve to promote the efflux of cholesterol from hepatic cell membranes. Hepatic cholesterol synthesis is then likely stimulated in the response to the depletion of hepatic cell membranes of cholesterol. We speculate that the enhanced synthesis of cholesterol and impaired conversion to bile acids, particularly during the early phase of drug response, contribute to the accumulation of FC in the plasma.  (+info)

Characterization of inducible nature of MRP3 in rat liver. (4/67)

We found previously that expression of multidrug resistance-associated protein (MRP) 3 is induced in a mutant rat strain (Eisai hyperbilirubinemic rats) whose canalicular multispecific organic anion transporter (cMOAT/MRP2) function is hereditarily defective and in normal Sprague-Dawley (SD) rats after ligation of the common bile duct. In the present study, the inducible nature of MRP3 was examined, using Northern and Western blot analyses, in comparison with that of other secondary active [Na(+)-taurocholic acid cotransporting polypeptide (Ntcp), organic anion transporting polypeptide 1 (oatp1), and organic cation transporter (OCT1)] and primary active [P-glycoprotein (P-gp), cMOAT/MRP2, and MRP6] transporters. alpha-Naphthylisothiocyanate treatment and common bile duct ligation induced expression of P-gp and MRP3, whereas expression of Ntcp, oatp1, and OCT1 was reduced by the same treatment. Although expression of MRP3 was also induced by administration of phenobarbital, that of cMOAT/MRP2, MRP1, and MRP6 was not affected by any of these treatments. Moreover, the mRNA level of MRP3, but not that of P-gp, was increased in SD rats after administration of bilirubin and in Gunn rats whose hepatic bilirubin concentration is elevated because of a defect in the expression of UDP-glucuronosyl transferase. However, the MRP3 protein level was not affected by bilirubin administration. Although the increased MRP3 mRNA level was associated with the increased concentration of bilirubin and/or its glucuronides in mutant rats and in SD rats that had undergone common bile duct ligation or alpha-naphthylisothiocyanate treatment, we must assume that factor(s) other than these physiological substances are also involved in the increased protein level of MRP3.  (+info)

Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats. (5/67)

It has been a desire to develop orally effective therapeutic agents that restore the liver function in chronic injury. Here we demonstrated that trans-4-L-hydroxyprolyl-L-serine (JBP923) and cyclo-trans-4-L-hydroxyprolyl-L-serine (JBP485), which was previously isolated from hydrolysate of human placenta, exhibit potent antihepatitis activity after their oral administration. The increase in bilirubin concentration and activities of liver cytosolic enzymes in serum caused by alpha-naphthylisothiocyanate intoxication in rats were significantly countered both after i.v. and oral administration of these dipeptides, whereas glycyrrhizin, which has been used in the treatment of chronic hepatitis, is active only after its i.v. administration. Antihepatitis activity of dipeptides results, at least partially, from their direct effect on hepatocytes because glutamic-oxaloacetic transaminase and lactate dehydrogenase activities in the medium of hepatotoxin-exposed primary cultured hepatocytes were reduced by these compounds. When comparing the plasma concentration-time profile of JBP923 after its i.v., oral, and portal vein injection, it is suggested that JBP923 is almost completely absorbed from gastrointestinal lumen, and hepatic first-pass removal is minor. JBP923 inhibited the proton-dependent transport of glycylsarcosine in brush-border membrane vesicles, suggesting that peptide transport system(s) may recognize JBP923. Thus, these dipeptides are potent antihepatitis reagents that are still active after oral administration and may be useful for clinical applications.  (+info)

Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. (6/67)

The purpose of this study was to evaluate the feasibility of metabonomics technology for developing a rapid-throughput toxicity screen using 2 known hepatotoxicants: carbon tetrachloride (CCl(4)) and alpha-naphthylisothiocyanate (ANIT) and 2 known nephrotoxicants: 2-bromoethylamine (BEA) and 4-aminophenol (PAP). In addition, the diuretic furosemide (FURO) was also studied. Single doses of CCl(4) (0.1 and 0.5 ml/kg), ANIT (10 and 100 mg/kg), BEA (15 and 150 mg/kg), PAP (15 and 150 mg/kg) and FURO (1 and 5 mg) were administered as single IP or oral doses to groups of 4 male Wistar rats/dose. Twenty-four-h urine samples were collected pretest, daily through Day 4, and on Day 10 (high dose CCl(4) and BEA only). Blood samples were taken on Days 1, 2, and 4 or 1, 4, and 10 for clinical chemistry assessment, and the appropriate target organ was examined microscopically. NMR spectra of urine were acquired and the data processed and subjected to principal component analyses (PCA). The results demonstrated that the metabonomic approach could readily distinguish the onset and reversal of toxicity with good agreement between clinical chemistry and PCA data. In at least 2 instances (ANIT and BEA), PCA analysis suggested effects at low doses, which were not as evident by clinical chemistry or microscopic analysis. Furosemide, which had no effect at the doses employed, did not produce any changes in PCA patterns. These data support the contention that the metabonomic approach represents a promising new technology for the development of a rapid throughput in vivo toxicity screen.  (+info)

Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein A-I transgenic rats is diminished through dose-dependent apolipoprotein A-I activation of LCAT. (7/67)

Administration of alpha-naphthylisothiocyanate (ANIT) to rats induces changes to plasma lipids consistent with cholestasis. We have previously shown (J. Lipid Res. 37 (1996) 1086) that animals treated with ANIT accumulate large amounts of free cholesterol (FC) and phospholipid (PL)-rich cholestatic lipoproteins in the LDL density range by 48 h. This lipid was cleared by 120 h through apparent movement into HDL with concomitant cholesteryl ester (CE) production. It was hypothesised that the clearance was mediated through the movement of the PL and FC into apolipoprotein A-I (apo A-I) containing lipoproteins followed by LCAT esterification to form CE. To test this hypothesis, rats overexpressing various amounts of human apo A-I (TgR[HuAI] rats) were treated with ANIT (100 mg/kg) and the effect of plasma apo A-I concentration on plasma lipids and lipoprotein distribution was examined. In untreated TgR[HuAI] rats, human apo A-I levels were strongly correlated to plasma PL (r(2)=0. 94), FC (r(2)=0.93) and CE (r(2)=0.90), whereas in ANIT-treated TgR[HuAI] rats, human apo A-I levels were most strongly correlated to CE levels (r(2)=0.80) and an increased CE/FC ratio (r(2)=0.62) and the movement of cholestatic lipid in the LDL to HDL. Since LCAT activity was not affected by ANIT treatment, these results demonstrate that the ability of LCAT to esterify the plasma FC present in cholestatic liver disease is limited by in vivo apo A-I activation of the cholestatic lipid and not by the catalytic capacity of LCAT.  (+info)

Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction. (8/67)

The anatomical details of the biliary tree architecture of normal rats and rats in whom selective proliferation was induced by feeding alpha-naphthylisothiocyanate (ANIT) were reconstructed in three dimension using a microscopic-computed tomography scanner. The intrahepatic biliary tree was filled with a silicone polymer through the common bile duct and each liver lobe embedded in Bioplastic; specimens were then scanned by a microscopic-computed tomography scanner and modified Feldkamp cone beam backprojection algorithm applied to generate three-dimensional images. Quantitative analysis of bile duct geometry was performed using a customized software program. The diameter of the bile duct segments of normal and ANIT-fed rats progressively decreased with increasing length of the biliary tree. Diameter of bile ducts from ANIT-fed rats (range, 21 to 264 microm) was similar to that of normal rats (22 to 279 microm). In contrast, the number of bile duct segments along the major branch reproducibly doubled, the length of the bile duct segments decreased twofold, and the length of the biliary tree remained unchanged after ANIT feeding. Moreover, the total volume of the biliary tree of ANIT-fed rats was significantly greater (855 microl) than in normal rats (47 microl). Compared with normal rats, the total surface area of the biliary tree increased 26 times after ANIT-induced bile duct proliferation. Taken together, these observations quantitate the anatomical remodeling after selective cholangiocyte proliferation and strongly suggest that the proliferative process involves sprouting of new side branches. Our results may be relevant to the mechanisms by which ducts proliferate in response to hepatic injury and to the hypercholeresis that occurs after experimentally induced bile duct proliferation.  (+info)

What rhymes with 1-naphthylisothiocyanate? Lookup it up at Rhymes.net - the most comprehensive rhyming words dictionary on the web!
Cholestasis is characterized by impaired bile flow, reduction of bile acids in the intestine, and retention of bile acids in the liver. Rats taken in alpha naphthylisothiocyanate (ANIT) have been one of the most common experimental models of intrahepatic cholestasis and used extensively, which was permitted to describe not only cholestatic alterations but also compensatory mechanisms [30]. The liver in ANIT-treated rats showed cholangiolitic hepatitis characterized by intrahepatic cholestasis, necrosis of hepatocytes and biliary epithelial cells and bile obstruction [31].. In current clinical practice, initial assessment of hepatobiliary diseases is accomplished by measuring serum concentrations of bile acids and bilirubin as well as serum activities of liver-associated enzymes which reveal information about the state of liver. Our previous study showed that the indexes of liver damage and pathological changes start to rise at 24h after ANIT treatment, reach a maximum at 48h and trend to restore ...
The aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) on the alpha-naphthylisothiocyanate (ANIT)-induced acute and recovery stage of cholestasis model mice. In the acute stage of model mice, pretreatment with UDCA (25, 50, and 100 mg·kg-1, ig) for 12 days prior to ANIT administration (50 mg·kg-1, ig) resulted in the dramatic increase in serum biochemistry, with aggrevation of bile infarcts and hepatocyte necrosis. The elevation of beta-muricholic acid (β-MCA), cholic acid (CA), and taurocholic acid (TCA) in serum and liver, and reduction of these bile acids (BAs) in bile was observed ...
Dr. Anit Patel, MD is a Critical Care Medicine Specialist in Fairfield, CA. Search for higher rated doctors in this area on Healthgrades.
Grafton Thomass attorney wrote in papers filed Monday that Rockland County did not perform an autopsy on 70-year-old Josef Neumann despite his request ...
Hello, have just had laptop cleared and cleaned of some worm, trojans and pop ups. Have installed avg anit virus and anti spy ware but I am having...
Melittin inhibits cholangiocyte proliferation in DDC-fed mice. Immunofluorescence staining shows co-localization of PCNA staining with CK-7 (arrow head) followi
TY - JOUR. T1 - Characterization and growth regulation of a rat intrahepatic bile duct epithelial cell line under hormonally defined, serum-free conditions. AU - De Groen, Piet C.. AU - Vroman, Ben. AU - Laakso, Karen. AU - Larusso, Nicholas F.. N1 - Funding Information: We are indebted to Ms. Sue Kuntz for valuable help in electron microscopy, Ms. Pare Tietz for animal surgeries, and Dr. Vanda Lennon and Mn James Thorenson for performing the nude mouse experiments. This research was supported by grants from the NIH (DK24031) and Mayo Foundation.. PY - 1998. Y1 - 1998. N2 - Bile duct epithelial cells, or cholangiocytes, proliferate in vivo under a number of pathologic (i.e., partial hepatectomy) and pathophysiologic (i.e., bile duct ligation, malignant transformation) conditions. However, little is known about the possible growth factors that modulate these proliferative responses, in part because an in vitro model to study proliferation of nontransformed, normal cholangiocytes is not available. ...
I publish regularly and frequently (,50); besides articles, I have written three book chapters, I give presentations at congresses and specialist events often and to a good response. I find it extremely important to raise a child with and for healthy life style, for years I had a German and Hungarian show on „Danubius and „Sláger Rádió, I regularly write medical-related articles, books and book chapters for the public; I translate specialist articles and I am a member of editorial committee of the Praxis journal ...
by TimH , Jun 22, 2015. According to current estimates, more than 300,000 patients-mostly people aged 65 and older-sustain a hip fracture each year in the United States, and the annual incidence is expected to exceed 500,000 by 2040. Hip fractures often result in nursing home stays, higher mortality, and lower quality of life. The expected rising incidence will place a significant financial burden on patients, families, insurers, and other key stakeholders. Surgery is the primary treatment strategy for hip fractures because it can reduce mortality risk and improve physical function, but less is known about the societal cost implications of hip fractures. New Data Little is known about the return on investment of surgery for hip fracture patients, says Lane Koenig, PhD. Policymakers and payers are increasingly focusing on value, making it critical to understand the return from healthcare spending, he says. To investigate this further, Dr. Koenig and colleagues conducted a study-published in ...
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and represses genes involved in bile acid biosynthesis. We investigated whether the synthetic FXR agonist GW4064 could protect against cholestatic liver damage in rat models of extrahepatic and intrahepatic cholestasis. In the bile duct-ligation and alpha-naphthylisothiocyanate models of cholestasis, GW4064 treatment resulted in significant reductions in serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase, as well as other markers of liver damage. Rats that received GW4064 treatment also had decreased incidence and extent of necrosis, decreased inflammatory cell infiltration, and decreased bile duct proliferation. Analysis
Duct epithelial cell - A cell type is a classification used to distinguish between morphologically or phenotypically distinct cell forms within a species.
Ive been tested for cholestasis twice and the results have comeback fine. Ive been itching for ten weeks and since it persists, my doctor wants m...
We saw no signs of fortification beyond this polnt, ex- acept here and there a (light stone-wall, such as I have already described. Perhaps my description may have conveyed the Ilea that the Mormon defences were really formidable. Belter natural positions far mil Itary. works could scarcely be found anywhere, b-i good as they aie, they afford few of the opportunitic for hurling rocks upon the columns of passing troop of which so much has been said. A traveling com panlon and your correspondent, wllh fin.a. 1 ibor clambered up Ihe cliffs on the north aide of the Canon, and Imd the experiment of rolling down some of the loose rocks frrtm a ledge jinrhaps H thousand leet above the road. We four,d a conglomerated mass of sainl, sloiie anit pebbles, poised upon the edge uf a ledge in such a position that our nulled strength W:IK fciifficlent lo lopple It over the brink. Away rolled the mass, crashing through the cedars, dashing upon a cliff btlow, ard flying Into a thousand pieces, bu scarce a ...
Hi all! I am so glad that there is an actual group for this! I had ICP with my last kiddo and was diagnosed about 34-35 weeks, I just had my levels...
TY - JOUR. T1 - Phenytoin liver glutathione depletion. A possible mechanism of liver injury. AU - Snodgrass, W. R.. AU - Whitfield, S.. PY - 1981. Y1 - 1981. N2 - Phenytoin produces significant liver glutathione depletion in vivo in mice. Pretreatment with inducers and inhibitors of drug metabolism show enhancement of phenytoin-induced glutathione depletion following phenobarbital and 3-methylcholanthrene pretreatment, inhibition of glutathione depletion following piperonyl butoxide, cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of glutathione depletion following butylated hydroxytoluene pretreatment (both inducers of epoxide hydrolase). These data suggest that phenytoin-induced liver glutathione depletion may occur via a reactive metabolite and that this reactive metabolite possibly may be an epoxide.. AB - Phenytoin produces significant liver glutathione depletion in vivo in mice. Pretreatment with inducers and inhibitors of ...
definition of SCIH, what does SCIH mean?, meaning of SCIH, Sickle Cell Intrahepatic Cholestasis, SCIH stands for Sickle Cell Intrahepatic Cholestasis
Unscramble cholestasis, Unscramble letters cholestasis, Point value for cholestasis, Word Decoder for cholestasis, Word generator using the letters cholestasis, Word Solver cholestasis, Possible Scrabble words with cholestasis, Anagram of cholestasis
My husband and I have had an excellent experience every time we have been in the office. Its worth the 65 mile drive for us! We could get all the services we receive across the street from our business, but we love the personalized experience and the expertise we receive at Dallas Anti Aging. We have been to many hormonal experts in the past, only to find they do not have the education and experience dealing with unique hormonal problems. We were looking for something other than the one size fits all approach to hormones, Dallas Anit Aging is definitely the place. The staff is incredibly gracious and attentive. I cant name specific names because they are all so amazing and friendly, I would not want to leave anyone out. Its refreshing to finally receive the answers I have been looking for, I wish we would have found Dallas Anti Aging sooner, but we are certainly blessed to have them now! ...
27 week appt yesterday and on top of out Trisomy 21 diagnosis I now gave cholestasis which means she will be delivered at 37 weeks to avoid possible complications. My poor baby girl. Even more so because of the DS diagnosis I just wanted her to stay cozy as long as possible
ANA MARIA KESE(1), VIOLETA COMaNESCU(2), MARIA COMaNESCU(2), CRISTIANA SIMIONESCU(3), DENISA ENESCU-BIERU(1) (1) Sport and Physical Education Faculty, University of Craiova; (2) Laboratory of Pathology, Emergency County Hospital Craiova; (3) Department of Pathology, University of Medicine and Pharmacy of Craiova ABSTRACT This study included 116 cases of liver serologically confirmed biopsies, which were clinico-pathologicaly assesed. We
Hi, Im currently pregnant with my 2nd. Im only 5/6 weeks so wouldnt have it yet anyway, but I developed OC first time round and ... Read more on Netmums
Participation of cholestatic factor in the pathogenesis of intrahepatic cholestasis in acute viral hepatitis. - Y Mizoguchi, Y Sakagami, H Tsutsui, T Monna, S Yamamoto, S Morisawa
Find out about itching during pregnancy, including causes, ways to ease itching, and when you need to seek medical attention fast for possible intrahepatic cholestasis of pregnancy (ICP), also called obstetric cholestasis.
Intrahepatic Cholestasis of Pregnancy {ICP} affects about 1 to 2 in 1,000 pregnant women. Read one moms story of trusting her intuition to get a diagnosis.
While oxidative stress is a commonly cited toxicological mechanism, conventional methods to study it suffer from a number of shortcomings, including destruction of the sample, introduction of potential artifacts, and a lack of specificity for the reactive species involved. Thus, there is a current need in the field of toxicology for non-destructive, sensitive, and specific methods that can be used to observe and quantify intracellular redox perturbations, more commonly referred to as oxidative stress. Here, we present a method for the use of two genetically-encoded fluorogenic sensors, roGFP2 and HyPer, to be used in live-cell imaging studies to observe xenobiotic-induced oxidative responses ...
This is my second pregnancy. I had ICP with my last and delivered at 36 weeks. At that time it took approximately 2 weeks to get a diagnosis. I...
Obstetric cholestasis is a rare condition that only affects you if you are pregnant. In the UK fewer than 1 in 100 pregnant women will develop it.
I am exactly 22 weeks pregnant and for the past 12 days I have been itching everywhere. When I first started itching I looked it up to see if it was related to pregnancy and why. Thats when I read about cholestasis. However since I itched literally everyone except the soles of…
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Objective : To determine the risk of adverse pregnancy outcomes resulting from intrahepatic cholestasis. Methods : We analyzed 91 women with singleton pregnancies complicated by cholestasis who gave birth at Kuopio University Hospital from January 1990 to December 1996. Logistic regression analysis was used to compare pregnancy outcomes of this...
Christina DePino thought the severe itching she felt was a normal symptom of pregnancy. Luckily she had gone to a checkup before things turned for the worse as she found out she could have given birth to a premature or stillborn baby and then shares awareness of cholestasis of pregnancy causes.
n of your full length CFTR cDNA. To investigate if any portion of the CFTR cDNA was being unintentionally expressed as a result of the presence of a cryptic
機能性RNAの変遷を通して, siRNAによる肝疾患治療システムの現状と展望を考える To consider an overview and prospect of therapy to hepatocellular injuries by using siRNA through history to the function of non-coading RNAs ...
Intrahepatic Cholestasis of Pregnancy (ICP), also termed Obstetric Cholestasis in the United Kingdom, is a reversible form of cholestasis, a liver disorder that occurs in pregnant women. ICP gives rise to troublesome itching during pregnancy but may lead to possibly serious complications for the mother and very serious outcomes for the fetus. Itching has long been considered to be a common symptom of pregnancy. The vast majority of times, itching, or pruritus is a minor annoyance caused by changes to the skin, especially that of the abdomen.. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy and recurs in 45 to 70% of subsequent pregnancies. Bile ...
A prospective study was undertaken to evaluate fat malabsorption during intrahepatic cholestasis of pregnancy (ICP), a disease characterized by a mild cholestasis of short duration appearing in otherwise healthy young women. An abnormal fecal fat exc
The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional. ...
The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional. ...
Understanding the key mechanistic and biologic processes in cholangiocytes is required to generate hypotheses and therapies relevant to disease. This compendium of current activities in cholangiocyte biology may promote collegial sharing and exchange of novel concepts, ideas, reagents and probes, th …
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Background Intrahepatic cholestasis of pregnancy (ICP) is an uncommon obstetric condition characterised by intense maternal pruritis and biochemical abnormality. There is a degree of contention regarding the diagnosis and management of ICP, and currently, there are no nationally accepted guidelines. Aims To conduct a survey of Fellows and Members of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) regarding their diagnosis and management ICP. Methods An online survey of currently practising RANZCOG Fellows and Members, utilising Survey Monkey. Results Thirty percent of those sent the survey responded, comprising approximately 40% of practising obstetricians. Fasting bile acid and serum transaminase elevation in association with the characteristic itch define the disease process for the majority of respondents and also inform management decisions. There was no critical level of bile acid elevation that mandated treatment for the majority of respondents. ...
A retrospective case-control study of 21,008 women in Finland has found that those with intrahepatic cholestasis of pregnancy (ICP), an itchy skin condition when bile gets backed up in the liver, are significantly more likely to suffer other liver diseases later in life.
Citation: Caperna, T.J., Blomberg, L., Garrett, W.M., Talbot, N.C. 2011. Culture of porcine hepatocytes or bile duct epithelial cells by inductive serum-free media. In Vitro Cellular and Developmental Biology - Animals. 47(3):218-233. Interpretive Summary: The study presents a method for the selective in vitro culture, i.e., in the petri dish, of pig hepatocytes and bile duct cells, i.e., liver cells. The report characterizes the cells general health and typrical in vivo-like, i.e., in the body-like, appearance and functions. Also, presented are data on specific liver gene expression and liver serum-protein production that again show that the hepatocytes and bile duct cell cultures are similar to liver cells found in a pigs own liver. For agricultural purposes, because the liver is so important to the growth and maintenance of the pig, this in vitro model could be useful for testing man-made genetic changes to the liver function of pigs prior to the actual genetic engineering of the pig, ...
The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis ...
Has anyone experienced intraheptic Cholestasis before ? I have an extreme itch that I cannot get to go away . No amount of itching or lotion or anything is helping . Ive been reading stories on the internet (I know , bad idea) about this and they all result in still birth . I have an appointment tomorrow but has anyone who has experienced this tell me differences between this and a regular itch ? I feel like crying because I cant stop itching
Isothiocyanate Naphthyl isothiocyanate Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue ... "Phenyl isothiocyanate". Organic Syntheses.CS1 maint: multiple names: authors list (link); Collective Volume, 1, p. 447 U.S. ...
... vitamin k 1 MeSH D04.615.638.721.374.844 - vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1- ... 10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 - methylcholanthrene MeSH D04.615.149.700 - perylene MeSH D04.615.181.384 ... 1-naphthylisothiocyanate MeSH D04.615.638.900 - naphthylvinylpyridine MeSH D04.615.638.930 - pravastatin MeSH D04.615.638.945 ...
Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 260 Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide ... Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V16 987 (1995) Cunningham, A. L., and J. V. Hurley. "Alpha‐ ... 1981., p. 1-2 NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases. U.S. Department of Health & Human Services, ... The usual method is the reaction of 1-naphthylamine hydrochloride with ammonium thiocyanate: [C10H7NH3]Cl + NH4SCN → C10H7NHC(S ...
... is a chemical compound which is an isothiocyanate derivative of naphthalene. CID 11080 from PubChem v ...
In contrast, the compounds cobalt chloride, piperonyl butoxide and alpha-naphthylisothiocyanate inhibit microsomal enzymes ... 56 (1): 28-35. doi:10.1128/AAC.05486-11. PMC 3256082. PMID 22037847. De Sagher, R.M.; Leenheer, A.P. De; Claeys, A.E. (1976-06- ... 187 (1): 185-194. ISSN 0022-3565. PMID 4746326. Tsarichenko, G. V.; Bobrov, V. I.; Smarkov, M. V. (1977-04-01). "Toxicity of ... 58 (1): 271-291. doi:10.1146/annurev-pharmtox-010617-052438. PMID 28715978. Lichtenstein, M.R.; Mizenberg, Edward (1954-05-01 ...
Prophylactic effect of four prescriptions of traditional Chinese medicine on α-naphthylisothiocyanate and carbon tetrachloride ... 1 (171-175) *↑ Bedi S., Goel A., Chand N., Rai J. A prospective study for evaluating the effect of Silymarin on hepatic ... 1 (S47-S48) *↑ In-vitro evaluation of hepatoprotecttve activity of Pergularia daemia Forsk Sureshkumar S.V., Mishra S.H. ... Haleagrahara N., Chakravarthi S., Kumar P. A study of protective effect of centella asiatica in 1-methyl-4phenyl-1,2,3,6- ...
1-Naphthyl isothiocyanate is a chemical compound which is an isothiocyanate derivative of naphthalene. CID 11080 from PubChem v ...
1-naphthyl isothiocyanate. ↓Other names: Regulatory process names [2] IUPAC names [3] ... Ss - Skin sensitiser (i.e. classified in skin sensitisation categories 1, 1A or 1B). More information about skin sensitiser ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ... Sr - Respiratory sensitiser (i.e. classified in respiratory sensitisation categories 1, 1A or 1B). More information about ...
Find quality suppliers and manufacturers of 1-Naphthyl isothiocyanatefor price inquiry.where to buy 1-Naphthyl isothiocyanate. ... Also offer free database of 1-Naphthyl isothiocyanate including MSDS sheet(poisoning, toxicity, hazards and safety),chemical ... a-Naphthyl isothiocyanate. 1-Naphthyl isothiocyanate Chemical Properties. Product Name: Isothiocyanic acid-1-naphthyl ester ( ... 1-Naphthyl isothiocyanate Toxicity Data With Reference. 1.. mmo-sat 100 µg/plate ABCHA6 44,3017,80 ...
... Lookup it up at Rhymes.net - the most comprehensive rhyming words dictionary on the ... Discuss this 1-naphthylisothiocyanate rhyme with the community:. Citation. Use the citation below to add this rhymes to your ... Weve got 0 rhyming words for 1-naphthylisothiocyanate ». What rhymes with 1-naphthylisothiocyanate?. This page is about the ... We couldnt find any rhymes for the word 1-naphthylisothiocyanate.. Maybe you were looking for one of these terms?. *twirled, - ...
Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats / Efeito ... injection of alpha-naphthylisothiocyanate (ANIT) (75 mg/kg body weight). The rats were pre-treated orally for 48hr (one dose / ... 24hr) with Ech (1, 5 and 10 mg/kg body weight) or ursodeoxycholic acid (UDCA) 80 mg/kg body weight drug then, injected with ... 1, 5 e 10 mg / kg de peso corporal) e ácido ursodeoxicólico (UDCA) 80 mg / kg de peso corporal, em seguida, injetado com ANIT. ...
Alpha-Naphthylisothiocyanate triggering G2/M phase arrest and apoptosis in human brain malignant glioma U87MG cells via ... "Alpha-Naphthylisothiocyanate Triggering G2/M Phase Arrest and Apoptosis in Human Brain Malignant Glioma U87MG Cells via ... Keywords: Alpha-naphthyl isothiocyanate, Apoptosis, Brain malignant glioma, G2/M phase, Mitochondria, U87MG cell ... Apaf-1, AIF, Endo G and the stimulated caspase-9 and -3 activity. ...
buta-1,3-diene decreases expression. EXP. 6480464. 1, 3-butadiene results in decreased expression of NAT8F2 mRNA. CTD. PMID: ... ovarian teratoma susceptibility 1 (mouse). Not determined. 6. 75447583. 104503555. Mouse. 1301571. Arrd1_m. age-related retinal ... amplitude of lateral head displacement 1 (mouse). 6. 78000000. 97000000. Mouse. 4141376. Dbm1_m. diabetes modifier 1 (mouse). ... P. aeruginosa infection resistance QTL 1 (mouse). 6. 81500000. 102200000. Mouse. 10043864. T2dm4sa_m. type 2 diabetes mellitus ...
1 1 45 1 1 9 14 4 1 Low. 1 4 1 86 5 6 3 109 86 11 5 11 4 46 2 113 10 2 2 3 6 1 1 2 1 1 5 1 1 1 6 37 1 1 4 1 1 1 1 1 9 1 2 1 4 1 ... 1 106 60 15 9 35 4 13 1 56 31 1 1 1 2 16 1 2 21 23 67 1 1 1 3 1 1 9 1 1 2 1 7 1 36 158 44 31 1 1 1 2 1 4 2 1 1 36 26 23 9 5 ... 1. 9,601,267 - 9,627,142 (+). NCBI. GRCm38. GRCm38. mm10. GRCm38. MGSCv37. 1. 9,591,348 - 9,617,223 (+). NCBI. GRCm37. mm9. ... Orthologs 1. Mus musculus (house mouse):. Vxn (vexin). HGNC. EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB ...
All-trans-retinoic acid improves cholestasis in α-naphthylisothiocyanate-treated rats and Mdr2-/- mice. ... Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease.. Mistry PK, Liu J, Sun L, Chuang WL, Yuen T, Yang R, Lu P, ... Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. ... 2013 Jan;14(1):3-5. doi: 10.1016/S1470-2045(12)70528-4. Epub 2012 Nov 28. No abstract available. ...
An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury. L J Dahm, A E Schultze and R A Roth ... An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury. L J Dahm, A E Schultze and R A Roth ... An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury. L J Dahm, A E Schultze and R A Roth ... A comparison of the hemodynamic effects of endothelin-1 and sarafotoxin S6b in conscious rats. S P Han, A J Trapani, K F Fok, T ...
... naphthylisothiocyanate. (1985) ... Articles in CiNii:1. * Role of acetone bodies in the abnormal ... Articles in CiNii:1. * Studies on Absorption of Drugs. IV. Effects of Surface Active Agents on Intestinal Absorption of Drugs ( ... Articles in CiNii:1. * Effect of 2,4-dinitrophenol on transport of cefmetazole and diclofenac from thigh muscle tissue and from ... Articles in CiNii:1. * Comparison of the effects of sesame oil and oleic acid as suspension vehicles on gastrointestinal ...
All-Trans-Retinoic Acid Improves Cholestasis in α-Naphthylisothiocyanate-Treated Rats and Mdr2−/− Mice Shi-Ying Cai, Albert ... Paradoxical Effects on Force Generation after Efficient β1-Adrenoceptor Knockdown in Reconstituted Heart Tissue Christiane ... Pharmacological Evaluation of Adipose Dysfunction via 11β-Hydroxysteroid Dehydrogenase Type 1 in the Development of Diabetes in ... Correction to "G Protein-Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a KCa1.1 (BKCa)- ...
Determination of alpha-naphthylisothiocyanate and metabolites alpha-naphthylamine and alpha-naphthylisocyanate in rat plasma ... Pharmacokinetics of alpha-naphthyl isothiocyanate in rats. J Pharm Sci. 2005; 94(11). ... 2003; 323(1).. *Kamath AV, Darling IM, Morris ME. Choline uptake in human intestinal Caco-2 cells is carrier-mediated. J Nutr. ... 2016; 511(1).. *Dave RA, Morris ME. A quantitative threshold for high/low extent of urinary excretion of compounds in humans. ...
Alpha‐naphthylisothiocyanate causes neutrophils to release factors that are cytotoxic to hepatocytes. Toxicol. Appl. Pharmacol ... Early changes in bile duct lining cells and hepatocytes in rats treated with alpha‐naphthylisothiocyanate. Toxicol. Appl. ... NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha‐naphthylisothiocyanate. ...
Plasma alkaline phosphodiesterase I in intrahepatic cholestasis induced by α -naphthylisothiocyanate in rats ... Administration of α-naphthylisothiocyanate (ANIT) to rats produced dose-dependent increases in plasma bile acid and bilirubin ... Administration of α-naphthylisothiocyanate (ANIT) to rats produced dose-dependent increases in plasma bile acid and bilirubin ... J. A. Summerfield; Julia Cullen; S. Barnes; Barbara H. Billing 1. The bile acids and bile acid sulphates in the urine, serum ...
AbdulHameed MD1, Tawa GJ1, Kumar K1, Ippolito DL2, Lewis JA2, Stallings JD2, Wallqvist A1. ... B) Activation at 1 day of exposure. The mapped expression profile is the average log2 ratio in 1-naphthyl isothiocyanate 30 mg/ ... The mapped expression profile is the average log2 ratio in 1-naphthyl isothiocyanate 30 mg/kg and 60 mg/kg, at 0.25-day ... The mapped expression profile is the average log2 ratio in 1-naphthyl isothiocyanate 30 mg/kg and 60 mg/kg, and 4,4- ...
Effects of alpha-naphthyl isothiocyanate and a heterocyclic amine, PhIP, on cytochrome P-450, mutagenic activation of various ... To elucidate the mechanism underlying suppression by alpha-naphthyl isothiocyanate (ANIT) of mammary carcinogenesis induced by ... 1 Pages. 15-22 Identifiers. PMID: 15598703 Source. Medline License. Unknown Abstract. ... 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), we evaluated hepatic levels of cytochrome P-450 (CYP) enzymes, ...
Y. Ding, L. Zhao, H. Mei et al., "Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via ... D. L. Eizirik, M. L. Colli, and F. Ortis, "The role of inflammation in insulitis and Β-cell loss in type 1 diabetes," Nature ... U. Christen, "Chemokines as drug targets in type 1 diabetes," Endocrine, Metabolic and Immune Disorders-Drug Targets, vol. 7, ... 1, no. 9, pp. 1241-1264, 2004. View at Publisher · View at Google Scholar · View at Scopus ...
Feeding 400 p.p.m. α-naphthyl isothiocyanate (ANIT) in a high fat diet for 3 weeks induced three CYP1A proteins but not CYP1A2 ... Aflatoxin B1-induced DNA damage was also suppressed in rats treated with grapefruit juice and an ethyl acetate extract of ... In contrast, DNA damage in target organ induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ( ... We thus set out to study the effects of quercetin conjugates on TNF-α-induced expression of intercellular adhesion molecule-1 ( ...
Isothiocyanate Naphthyl isothiocyanate Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue ... "Phenyl isothiocyanate". Organic Syntheses.CS1 maint: multiple names: authors list (link); Collective Volume, 1, p. 447 U.S. ...
Plasma alkaline phosphodiesterase I in intrahepatic cholestasis induced by α -naphthylisothiocyanate in rats Clin Sci (Lond) ( ... 1. The biliary excretion of total bilirubin and bile acids, and the fate of tracer doses of radioactive sulphated and non- ... The biliary excretion of radioactive labelled sulphated bile acids is low for at least 1 week after biliary drainage, but later ... Clin Sci (Lond) 1 July 1984; 67 (1): 61-68. doi: https://doi.org/10.1042/cs0670061 ...
... α-naphthylisothiocyanate," Biochemical Pharmacology, vol. 64, no. 1, pp. 67-77, 2002. View at Publisher · View at Google ... 1. and C. 13. HR-MAS spectroscopy of intact biopsy samples ex vivo and in vivo H. 1. MRS study of human high grade gliomas," ... 1. - and B. 1. -insensitive water-suppression method for in vivo localized H. 1. NMR spectroscopy," Journal of Magnetic ... D. F. Brougham,1,2 G. Ivanova,1,3 M. Gottschalk,1 D. M. Collins,1 A. J. Eustace,1 R. OConnor,1,4 and J. Havel5 ...
The effect of α-naphthylisothiocyanate (ANIT) on blood clearance of <99m>Tc-phytate (<99m>Tc-P) in rats was examined, ... EFFECT OF α-NAPHTHYLISOTHIOCYANATE ON BLOOD CLEARANCE OF <99m>Tc-PHYTATE IN RATS ... The rats that received an intravenous injection of CER in dose of 1, 000 mg/kg body weight, showed two peaks at the 1-hour and ... Since the color development of CER determined in the chemical method showed that 1 g of CER corresponded to 0.0208 g of ...
00157] As outlined above, administration of alpha-naphthylisothiocyanate (ANIT) can induce chronic cholangitis if administered ... R A2 is R A1 , -C(O)R A1 , -C 6 -C 12 aryl, -C 6 -C 12 alkaryl, -C 6 -C 12 alkenaryl, -SO 2 -C 1 -C 6 alkyl, - SO 2 -C 6 -C 12 ... R A2 is R A1 , -C(O)R A1 , -C 6 -C 12 aryl, -C 6 -C 12 alkaryl, -C 6 -C 12 alkenaryl, -SO 2 -C 1 -C 6 alkyl, - SO 2 -C 6 -C 12 ... R A2 is R A1 , -C(O)R A1 , -C 6 -C 12 aryl, -C 6 -C 12 alkaryl, -C 6 -C 12 alkenaryl, -SO 2 -C 1 -C 6 alkyl, - SO 2 -C 6 -C 12 ...
The LODs were 0.35 mg L−1 for histamine, 0.33 mg L−1 for phenylethylamine and 0.37 mg L−1 for tyramine [81]. In a more recent ... The obtained LODs were 3.82-31.3 ng L−1. Apart from that, the LODs of 0.25-50 μg L−1 were obtained by Huang et al. [40], ... The LODs were 0.3-2.9 μg L−1 [73]. Also, Cunha et al. elaborated a GC-MS method and used IBCF to determine the content of 22 ... The LODs in fruit juice samples were 56-1630 μg L−1 [67], whereas the LODs in wine samples were 23-68 μg kg−1 [68]. Ion ...
... on α-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury with the focus on bile acid... ... medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats. J Ethnopharmacol 172:202-213CrossRefGoogle ... on α-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury with the focus on bile acid homeostasis and anti- ... 1.Department of Pharmacy, Shanghai 9th Peoples HospitalShanghai Jiao Tong University School of MedicineShanghaiChina ...
6 ml/kg), group B (po alpha-naphthylisothiocyanate(ANIT) 50 mg/kg. Posted on July 29, 2018. by admin ... 6 ml/kg), group B (po alpha-naphthylisothiocyanate(ANIT) 50 mg/kg+ ip saline 0.6 ml/kg), group C (po ANIT as group B + ip SAMe ... Vegfr-1 Inhibitor. Potent VEGFR Inhibitors Widely Used in NCBIs Publications. Search. Main menu. Skip to primary content ... Key Word(s): 1. SAMe; 2. IHC; Presenting. Author: SONG ZHANG Additional Authors: JING HUO, LIPING TONG, LI DING, WENQIANG FENG ...
... alpha-naphthylisothiocyanate (ANIT: 40 mg/kg), or D-galactosamine (GalN: 400 mg/kg), the half-life (t1/2) of caffeine and ... 1. Seizures (Seizure) 01/01/1972 - "1. The effects of amino-oxyacetic acid (AOAA) on the central nervous system and on skeletal ... also total body clearance of caffeine correlated well with the ratio of dimethadione/trimethadione after 1, 2, and 4 hr of ...
Protective effect of Calculus Bovis Sativus on intrahepatic cholestasis in rats induced by alpha-naphthylisothiocyanate. Am. J ... mussotii exhibited significant hepatoprotective effect on alpha naphthylisot hiocyanate-induced liver damage in mice (Tian et ... Qi Li1, Hai-Jiao Li1, Tong Xu2, Huan Du1, Chen-Lei Huan Gang2, Gang Fan2,3* and Yi Zhang2 ... FIGURE 1. Figure 1. The number and percentage of traditional Tibetan medicines used in the treatment of various liver diseases. ...
alpha Naphthylisothiocyanate. alpha-Naphthylisothiocyanate. Tree number(s):. D02.455.426.559.847.638.870. D02.500.375.625. ... 91(77); was see under THIOCYANATES 1977-90; was ALPHA-NAPHTHYLISOTHIOCYANATE (see under THIOCYANATES 1976); ANIT was see 1- ... 91; was see under THIOCYANATES 1977-90; was ALPHA-NAPHTHYLISOTHIOCYANATE (see under THIOCYANATES 1976); ANIT was see 1- ... 1-Naphthylisothiocyanate - Preferred Concept UI. M0023170. Scope note. A tool for the study of liver damage which causes bile ...
  • Abstract The present study was designed to evaluate the protective effects of echinochrome (Ech) on intrahepatic cholestasis in rats induced by a single (i.p.) injection of alpha-naphthylisothiocyanate (ANIT) (75 mg/kg body weight ). (bvsalud.org)
  • The rats were pre-treated orally for 48hr (one dose / 24hr) with Ech (1, 5 and 10 mg/kg body weight ) or ursodeoxycholic acid (UDCA) 80 mg/kg body weight drug then, injected with ANIT. (bvsalud.org)
  • Os ratos foram pré- tratados oralmente durante 48 horas (uma dose / 24 horas) com cada (1, 5 e 10 mg / kg de peso corporal ) e ácido ursodeoxicólico (UDCA) 80 mg / kg de peso corporal , em seguida, injetado com ANIT. (bvsalud.org)
  • Western blot analysis and colorimetric assays also displayed that ANIT caused a time-dependent increase in cytosolic cytochrome c , pro-caspase-9, Apaf-1, AIF, Endo G and the stimulated caspase-9 and -3 activity. (banglajol.info)
  • To elucidate the mechanism underlying suppression by alpha-naphthyl isothiocyanate (ANIT) of mammary carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), we evaluated hepatic levels of cytochrome P-450 (CYP) enzymes, mutagenic activation of environmental carcinogens and UDP-glucuronyltransferase (UDPGT) activities in female Sprague-Dawley rats fed a high fat diet. (mysciencework.com)
  • Administration of α-naphthylisothiocyanate (ANIT) to rats produced dose-dependent increases in plasma bile acid and bilirubin concentrations. (portlandpress.com)
  • The purpose of this study was to investigate the pharmacological effects of salvianolic acid B (SA-B) on α-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury with the focus on bile acid homeostasis and anti-inflammatory pathways. (springer.com)
  • Chronic cholestasis was induced by 0.1%α-naphthylisothiocyanate (ANIT) feeding immediately after the transfer of AEC. (elsevier.com)
  • Alpha-naphthylisothiocyanate (ANIT) is an experimental agent used to induce intrahepatic cholestasis. (readbyqxmd.com)
  • To study the changes of pharmacokinetics of 6,7-dimethoxycoumarin in a rat model of alpha-naphthylisothiocyanate (ANIT)-induced experimental hepatic injury after oral administration of Yinchenhao Decoction (, YCHD) using an ultra pressure liquid chromatography (UPLC) method. (bvsalud.org)
  • OBJECTIVE:To investigate the therapeutic mechanism of compound Yindan decoction (CYD) in a rat model of acute intrahepatic cholestatic (AIC).METHODS:A total of 108 adult male rats were randomly divided into control (n =18) and AIC groups (n =90).AIC was induced in rats using alpha-naphthylisothiocyanate (ANIT)(75 mg/kg,10 mL/kg in corn oil,p.o. (cqvip.com)
  • RNA samples from the livers of rats treated for 5 days with five tool hepatotoxicants (α-naphthylisothiocyanate/ANIT, carbon tetrachloride/CCl 4 , methylenedianiline/MDA, acetaminophen/APAP, and diclofenac/DCLF) were analyzed with both gene expression platforms (RNA-Seq and microarray). (nih.gov)
  • Consistent with the mechanisms of toxicity of ANIT, APAP, MDA and CCl 4 , both platforms identified dysregulation of liver relevant pathways such as Nrf2, cholesterol biosynthesis, eiF2, hepatic cholestasis, glutathione and LPS/IL-1 mediated RXR inhibition. (nih.gov)
  • Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by Alpha-naphthylisothiocyanate. (readbyqxmd.com)
  • Rolo AP, Oliveira PJ, Seiça R, Santos MS, Moreno AJ, Palmeira CM. Improved efficiency of hepatic mitochondrial function in rats with cholestasis induced by an acute dose of alpha-naphthylisothiocyanate. (umassmed.edu)
  • Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase. (aspetjournals.org)
  • chronic experimental fibrosis and cirrhosis induction in rats were investigated using (1)H NMR spectroscopy of liver extracts and serum combined with pattern recognition techniques. (labome.org)
  • Waters N, Holmes E, Waterfield C, Farrant R, Nicholson J. NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate. (labome.org)
  • 2015) Resveratrol Attenuates Intermittent Hypoxia-Induced Insulin Resistance in Rats: Involvement of Sirtuin 1 and the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase/AKT Pathway. (hanspub.org)
  • 1. The metabolism of [1,2-(14)C]-ethylene glycol and [1,2-(14)C]-glycolic acid was studied in vitro using precision-cut tissue slices prepared from the livers of female Sprague-Dawley rats, New Zealand white rabbits and humans. (biomedsearch.com)
  • Journal Article] An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide : its potential use for preclinical chemoprevention studies. (nii.ac.jp)
  • 1-Naphthyl isothiocyanate is a chemical compound which is an isothiocyanate derivative of naphthalene. (wikipedia.org)
  • In- sert: Close-up of channels fact, 1-naphthyl-isothiocyanate (NITC) increased the accu- mulation of daunomycin (DNM) and vinblastine (VBL) significantly in both resis- tant cell lines. (forexwalkthrough.com)
  • Pretreatment with inducers and inhibitors of drug metabolism show enhancement of phenytoin-induced glutathione depletion following phenobarbital and 3-methylcholanthrene pretreatment, inhibition of glutathione depletion following piperonyl butoxide, cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of glutathione depletion following butylated hydroxytoluene pretreatment (both inducers of epoxide hydrolase). (utmb.edu)
  • 1. We have applied the concept of using MBIs to produce CYP-Silensomes to quantify the contribution of the major CYPs to drug metabolism (fmCYP). (biopredic.com)
  • To study the efficacy of marrow mesenchymal stem cells (MSCs) transplantation combined with interleukin-1 receptor antagonist (IL-1Ra) for acute liver failure (ALF). (termsreign.ml)
  • Effects of Pristine C60 Fullerenes on Liver and Pancreas in alpha-Naphthylisothiocyanate-Induced Cholangitis. (amedeo.com)
  • 1. The biliary excretion of total bilirubin and bile acids, and the fate of tracer doses of radioactive sulphated and non-sulphated bile acids, were studied in patients with percutaneous transhepatic bile drainage. (portlandpress.com)
  • The biliary excretion of radioactive labelled sulphated bile acids is low for at least 1 week after biliary drainage, but later becomes the predominant route for excretion in the anicteric patient. (portlandpress.com)
  • At the infusion rate of 1.4 nmol·min -1 ·kg -1 , glucagon increased bile flow from 206.6 ± 14.3 to 302.6 ± 35.0 μl·min -1 ·kg -1 and bicarbonate biliary concentration from 63.7 ± 4.2 to 75.5 ± 5.9 meq/l. (elsevier.com)
  • Measurements of bile acid excretion in bile, the biliary tree volume, and of the hormone choleretic effect in guinea pigs with proliferated bile ductules/ducts induced by α-naphthylisothiocyanate feeding indicated that glucagon, unlike secretin, stimulated canalicular bile flow. (elsevier.com)
  • 2014) Danning Tablets Attenuates α-Naphthylisothiocyanate-Induced Cholestasis by Modulating the Expression of Transporters and Metabolic Enzymes. (hanspub.org)
  • What rhymes with 1-naphthylisothiocyanate? (rhymes.net)
  • This page is about the various possible words that rhymes or sounds like 1-naphthylisothiocyanate . (rhymes.net)
  • We couldn't find any rhymes for the word 1-naphthylisothiocyanate . (rhymes.net)
  • What rhymes with 1-hitter ? (definitions.net)
  • Isothiocyanic acid-1-naphthyl ester (CAS NO.551-06-4) is used as analytical reagents and organic synthesis intermediates. (lookchem.com)
  • 1. Gamma-hydroxybutyric acid (GHB) Toxicokinetics and Toxicodynamics. (buffalo.edu)
  • rOatp1a4 shares 77% amino acid sequence identity with the earlier identified rOatp1a1 [1, 5-7], and it was renamed from Oatp2 upon introduction of the new nomenclature in 2004 [8]. (solvobiotech.com)
  • We identified a PPI network module associated with liver fibrosis that includes known liver fibrosis-relevant genes, such as tissue inhibitor of metalloproteinase-1, galectin-3, connective tissue growth factor, and lipocalin-2. (nih.gov)
  • The transforming growth factor-β, connective tissue growth factor, α-smooth muscle actin, collagen 1, and interleukin-10 proteins and mRNAs were measured by Western blot and polymerase chain reaction, respectively. (nih.gov)
  • Western blot assays showed decreased expression levels of transforming growth factor-β, connective tissue growth factor, α-smooth muscle actin, and collagen 1 in the coffee- and caffeine-treated BDL groups. (nih.gov)
  • High-resolution magic angle spinning (HRMAS) (1)H NMR spectroscopy is ideal for monitoring the metabolic environment within tissues, particularly when spectra are weighted by physical properties such as T(1) and T(2) relaxation times and apparent diffusion coefficients (ADCs). (biomedsearch.com)
  • In addition, dioscin markedly inhibited PI3K/Akt pathway and up-regulated the levels of Nrf2, GCLc, GCLm, NQO1 and HO-1 against oxidative stress (OS) caused by bile acids. (frontiersin.org)
  • Allen K, Kim ND, Moon JO et al (2010) Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling. (springer.com)
  • The genes encoding the coat protein (CP) and triple gene block protein 1 (TGBp1) of Potato virus M (PVM) were cloned into expression vector pET-45b(+) (N-terminal 6xHis tag) and expressed in E. coli Rosetta gami-2(DE3). (vegfr-1inhibitor.com)
  • Silencing of Nrf2 by siRNA gene knockdown rendered the MCF10A cells less sensitive to the EGCG-induced expression of HO-1 and MnSOD. (termsreign.ml)
  • Expression of Programmed Death Ligand 1 Is Associated with the Prognosis of Intrahepatic Cholangiocarcinoma. (amedeo.com)
  • Moreover, SA-B suppressed NF-κB translocation into the nucleus, inhibited phosphorylation of p38 and JNK, and inhibited inflammation markers including IL-1β, IL-6, TGF-β, TNF-α, and COX-2 to extenuate cholestatic liver injury both in vivo and vitro. (springer.com)
  • Upon challenge with a hepatotoxic diet containing 0.1 % 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), SULT2B1 −/− mice presented alleviated liver injury and less HOC proliferation compared with wild-type (WT) mice, and these findings were verified by serum analysis, histopathology, immunofluorescence staining, RNA-seq, and Western blotting. (springer.com)
  • Rat liver 10-formyltetrahydrofolate dehydrogenase, carbamoyl phosphate synthetase 1 and betaine homocysteine S-methytransferase were co-purified on Kunitz-type soybean trypsin inhibitor-coupled sepharose CL-4B. (labome.org)
  • NMR mobile lipid intensity and cholesterol in two human tumor multidrug resistant cell lines (MCF-7 and LoVo)," Biochimica et Biophysica Acta , vol. 1531, no. 1-2, pp. 111-131, 2001. (hindawi.com)
  • It has also been recently discovered that ADPKD is a result of mutations in PKD1 or PKD2, genes encoding polycystin-1 (PC-1), a cell surface receptor, and polycystin-2 (PC-2), a Ca 2+ channel, two integral membrane proteins normally localized to primary cilia. (pubmedcentralcanada.ca)
  • At 11.5 gestational days, 1 × 10 5 AEC were isolated from EGFP-transgenic mouse embryos and transferred into C57BL/6 mice. (elsevier.com)
  • Journal Article] Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. (nii.ac.jp)
  • Inhibition of prostaglandin synthesis by indomethacin administration (5 mg·kg -1 ·h -1 ) did not modify the choleretic effect of glucagon, and infusion of a glucagon analogue (TH-glucagon, 1.4 nmol·min -1 ·kg -1 ), which did not increase hepatic formation of adenosine 3'5'-cyclic monophosphate (cAMP), failed to stimulate bile flow. (elsevier.com)
  • 【Abstract】: Cholestatic liver disease is one of the common diseases in children aged <1 year and has a complex etiology and different outcomes. (lcgdbzz.org)
  • identifications were verified by their high translation elongation factor 1-alpha (TEF1) sequence similarity with those of the species epitypes. (vegfr-1inhibitor.com)
  • S-adenosyl-L-methionine protection against alpha-naphthylisothiocyanate-induced cholestasis in the rat. (termsreign.ml)
  • The incidence of hyperploidy was significantly increased in oocytes cultured with 0.6 μg/mL or higher concentration of MBC, while the incidence of diploidy was significantly increased in oocytes cultured with 1 or 3 μg/mL of GF. (go.jp)
  • Changes in liver function were monitored by the levels of liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST)] and bilirubins [total bilirubin (TBIL), direct bilirubin (DBIL)], the concentration of 6,7-dimethoxycoumarin in plasma were measured by UPLC, and the pharmaceutical parameters were calculated with DAS2.1.1 software. (bvsalud.org)
  • The compound according to any preceding claim, wherein R 2 has the 4) The compound according to any preceding claim, wherein R 3 is H, or -C 1 -C 6 alkyl, such as methyl, ethyl, propyl, butyl, pentyl, hexyl or isomers thereof. (sumobrain.com)