1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.2-Naphthylamine: A naphthalene derivative with carcinogenic action.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.DiethylaminesDimethylaminesMolecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Hydroxylamines: Organic compounds that contain the (-NH2OH) radical.Caustics: Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year.Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)Isocyanates: Organic compounds that contain the -NCO radical.Nitric Acid: Nitric acid (HNO3). A colorless liquid that is used in the manufacture of inorganic and organic nitrates and nitro compounds for fertilizers, dye intermediates, explosives, and many different organic chemicals. Continued exposure to vapor may cause chronic bronchitis; chemical pneumonitis may occur. (From Merck Index, 11th ed)Cyanates: Organic salts of cyanic acid containing the -OCN radical.Distillation: A chemical process for separating the components of a liquid mixture by boiling and collecting condensed vapors.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.Manufactured Materials: Substances and materials manufactured for use in various technologies and industries and for domestic use.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Facility Regulation and Control: Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.Investigational New Drug Application: An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Visual Prosthesis: Artificial device such as an externally-worn camera attached to a stimulator on the RETINA, OPTIC NERVE, or VISUAL CORTEX, intended to restore or amplify vision.United StatesVirginiaConstruction Materials: Supplies used in building.KansasPsychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.Color Perception Tests: Type of vision test used to determine COLOR VISION DEFECTS.HydrocarbonsNational Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)Herpes Zoster: An acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area. (From Dorland, 27th ed)September 11 Terrorist Attacks: Terrorism on September 11, 2001 against targets in New York, the Pentagon in Virginia, and an aborted attack that ended in Pennsylvania.
(1/96) Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro.

We previously demonstrated (M. M. Exner, P. Doig, T. J. Trust, and R. E. W. Hancock, Infect. Immun. 63:1567-1572, 1995) that Helicobacter pylori has at least one nonspecific porin, HopE, which has a low abundance in the outer membrane but forms large channels. H. pylori is relatively susceptible to most antimicrobial agents but less susceptible to the polycationic antibiotic polymyxin B. We demonstrate here that H. pylori is able to take up higher basal levels of the hydrophobic fluorescent probe 1-N-phenylnaphthylamine (NPN) than Pseudomonas aeruginosa or Escherichia coli, consistent with its enhanced susceptibility to hydrophobic agents. Addition of polymyxin B led to a further increase in NPN uptake, indicative of a self-promoted uptake pathway, but it required a much higher amount of polymyxin B to yield a 50% increase in NPN uptake in H. pylori (6 to 8 microg/ml) than in P. aeruginosa or E. coli (0.3 to 0.5 microg/ml), suggesting that H. pylori has a less efficient self-promoted uptake pathway. Since intrinsic resistance involves the collaboration of restricted outer membrane permeability and secondary defense mechanisms, such as periplasmic beta-lactamase (which H. pylori lacks) or efflux, we examined the possible role of efflux in antibiotic susceptibility. We had previously identified in H. pylori 11637 the presence of portions of three genes with homology to potential restriction-nodulation-division (RND) efflux systems. It was confirmed that H. pylori contained only these three putative RND efflux systems, named here hefABC, hefDEF, and hefGHI, and that the hefGHI system was expressed only in vivo while the two other RND systems were expressed both in vivo and in vitro. In uptake studies, there was no observable energy-dependent tetracycline, chloramphenicol, or NPN efflux activity in H. pylori. Independent mutagenesis of the three putative RND efflux operons in the chromosome of H. pylori had no effect on the in vitro susceptibility of H. pylori to 19 antibiotics. These results, in contrast to what is observed in E. coli, P. aeruginosa, and other clinically important gram-negative bacteria, suggest that active efflux does not play a role in the intrinsic resistance of H. pylori to antibiotics.  (+info)

(2/96) Effect of polymorphisms on ligand binding by mouse major urinary proteins.

Mouse urine contains an abundance of major urinary proteins, lipocalins, whose roles include slow release of semiochemicals. These proteins are highly polymorphic, with small sequence differences between individual members. In this study, we purified to homogeneity four of these proteins from two strains of inbred mice and characterized them by mass spectrometry. This analysis has led to the discovery of another variant in this group of proteins. Three of the polymorphic variants that map to the surface have no effect on the binding of a fluorescent probe in the binding cavity, but the fourth, characterized by a Phe to Val substitution in the cavity, shows a substantially lower affinity and fluorescence yield for the probe. These results are interpreted in light of the known crystal structure of the protein and molecular modeling calculations, which rationalize the experimental findings. This work raises the possibility that the calyx-binding site can show specificity for different ligands, the implications of which on pheromone binding and chemical communication are discussed.  (+info)

(3/96) The micronucleus assay in human exfoliated urothelial cells: application in a genotoxicity study of workers exposed to a mineral jelly containing sodium nitrite and N-phenyl-1-naphthylamine.

Exposure to certain chemical agents in occupational settings has been identified as carcinogenic to the human bladder. Micronucleus (MN) analysis in exfoliated urothelial cells is an interesting method for biomonitoring genetic damage in human populations. However, few studies have been performed in an occupational context. The aim of this study was to examine whether the occupational use of a mineral jelly induced a genotoxic risk for workers employed at a single factory producing bearings using the MN test on exfoliated urothelial cells. The prevalence of micronucleated exfoliated urothelial cells (MNC) was determined in 35 female workers with dermal exposure to the jelly and 41 female controls. The mean percentage of MNC (expressed as percent cells with MN per 1000 cells scored) observed in the exposed worker group was 0.46 +/- 0.11% (range 0-2.8) and in the control group 0.14 +/- 0.03% (range 0-0.8). There is a significant job effect (P = 0.0018, MANCOVA) on the prevalence of MNC, whereas age and smoking habit had no significant effect (P = 0.90 and 0.91, respectively). There is no interaction between job and smoking habit (P = 0.4421). Exposure to the mineral jelly appeared to be the main factor inducing the increased prevalence of MNC. This may be due to the presence of mutagens/carcinogens in the jelly: an aromatic amine, N-phenyl-1-naphthylamine (CAS no. 90-30-2), which is carcinogenic in mice, or sodium nitrite (CAS no. 7632-00-0), which is genotoxic in human cell systems. In conclusion, these results suggest that use of the mineral jelly could present a genotoxic risk for workers. We think that the MN assay on exfoliated cells could be valuable for biological monitoring purposes in occupational contexts as a marker of significant exposure to bladder mutagenic/carcinogenic agents.  (+info)

(4/96) Specific interactions of the antimicrobial peptide cyclic beta-sheet tachyplesin I with lipopolysaccharides.

The cyclic beta-sheet antimicrobial peptide tachyplesin I (T-SS) was found to show 280-fold higher affinity for lipopolysaccharides (LPS) compared with acidic phospholipids, whereas the linear alpha-helical peptide F5W-magainin 2 (MG2) could not discriminate between LPS and acidic phospholipids. The recognition site was the lipid A moiety and the cyclic structure was crucial to this specific binding. The cyclic structure also endowed the peptide with very rapid outer membrane (OM) permeabilization.  (+info)

(5/96) Rhamnolipid stimulates uptake of hydrophobic compounds by Pseudomonas aeruginosa.

The biodegradation of hexadecane by five biosurfactant-producing bacterial strains (Pseudomonas aeruginosa UG2, Acinetobacter calcoaceticus RAG1, Rhodococcus erythropolis DSM 43066, R. erythropolis ATCC 19558, and strain BCG112) was determined in the presence and absence of exogenously added biosurfactants. The degradation of hexadecane by P. aeruginosa was stimulated only by the rhamnolipid biosurfactant produced by the same organism. This rhamnolipid did not stimulate the biodegradation of hexadecane by the four other strains to the same extent, nor was degradation of hexadecane by these strains stimulated by addition of their own biosurfactants. This suggests that P. aeruginosa has a mode of hexadecane uptake different from those of the other organisms. Rhamnolipid also enhanced the rate of epoxidation of the aliphatic hydrocarbon alpha,omega-tetradecadiene by a cell suspension of P. aeruginosa. Furthermore, the uptake of the hydrophobic probe 1-naphthylphenylamine by cells of P. aeruginosa was enhanced by rhamnolipid, as indicated by stopped-flow fluorescence experiments. Rhamnolipid did not stimulate the uptake rate of this probe in de-energized cells. These results indicate that an energy-dependent system is present in P. aeruginosa strain UG2 that mediates fast uptake of hydrophobic compounds in the presence of rhamnolipid.  (+info)

(6/96) Effect of EDTA on Salmonella enterica serovar Typhimurium involves a component not assignable to lipopolysaccharide release.

The effect of EDTA on Salmonella enterica serovar Typhimurium was studied in different growth phases with cells grown with or without Ca(2+) and Mg(2+) supplementation. EDTA affected the outer membrane much more strongly in the early exponential phase than in the mid- or late exponential phase, as indicated by uptake of 1-N-phenylnaphthylamine (a nonpolar hydrophobic probe, M(r) 219), and detergent (SDS) susceptibility. This effect was, however, not paralleled by LPS release (determined by measuring LPS-specific fatty acids or 14C-labelled LPS in cell-free supernatants, per a standardized cell density), which remained unchanged as a function of the growth curve. The conclusion from these results is that in the early exponential phase the effect of EDTA in S. enterica involves a component that is independent of LPS release.  (+info)

(7/96) Neuroendocrine response to clonidine and 8-OH-DPAT in rats following chronic administration of desipramine or sertraline.

1. Rats were administered either desipramine (DMI) or sertraline daily at doses 7.5 mg kg-1 or 10 mg kg-1, i.p., respectively and the effects on the functional state of hypothalamic neuroendocrine control mechanisms assessed by measurements of plasma hormones following acute drug challenge. The effects of treatment on gross behaviour and brain adrenoceptor density were also determined. 2. Both DMI and sertraline caused significant reduction in activity measured as ambulation and rearing at 14 days of treatment. 3. All animals were chronically cannulated after 14 days of treatment and tested for neuroendocrine response to acute i.v. clonidine (50 micrograms kg-1) or 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 250 micrograms kg-1) after 21 or more days of treatment. 4. Rats treated with DMI but not sertraline showed a virtually complete suppression of the growth hormone (GH) secretion elicited by clonidine in controls, while the secretion of corticosterone was augmented. 5. Treatment with DMI but not sertraline led to a significantly greater 8-OH-DPAT-induced secretion of prolactin than in the control rats, while the plasma concentrations of corticosterone following 8-OH-DPAT were not influenced by either DMI or sertraline treatment. 6. The density (but not the affinity) of cerebral cortical binding of [3H]-dihydroalprenolol was significantly reduced by DMI treatment. 7. These results show that DMI treatment blunted the sensitivity of post-synaptic alpha 2-adrenoceptors, accompanied by complex interactions manifested as increased responsiveness of alpha 1-adrenoceptors and 5-HT1A receptors. Sertraline had no significant neurendocrine effects at a dose which significantly reduced gross activity.  (+info)

(8/96) The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs might inhibit CYP2D6, the effects of five SSRIs on human liver microsomal CYP2D6 activity were compared with each other and with three tricyclic antidepressant drugs. On a molar basis, paroxetine was the most potent of the SSRIs at inhibiting the CYP2D6-catalysed oxidation of sparteine (Ki = 0.15 microM), although fluoxetine (0.60 microM) and sertaline (0.70 microM) had Ki values in the same range. Fluvoxamine (8.2 microM) and citalopram (5.1 microM) also inhibited CYP2D6 activity. The major circulating metabolites of paroxetine in man produced negligible inhibition. In contrast, norfluoxetine the active metabolite of fluoxetine, was a potent CYP2D6 inhibitor (0.43 microM). CYP2D6 activity was also diminished by the tricyclic antidepressant drugs clomipramine (2.2 microM), desipramine (2.3 microM) and amitriptyline (4.0 microM). These findings suggest that compounds with SSRI activity are likely to interact with human CYP2D6 in vivo with the potential of causing drug interactions.  (+info)

*  1-Naphthylamine
... the naphthylamine steam-distilled. It can also be prepared, in the form of its acetyl derivative, by heating 1-naphthol with ... 1-Naphthylamine is an aromatic amine derived from naphthalene.It can cause Bladder Cancer. It crystallizes in colorless needles ... It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid at about 70 °C. After the reaction mixture is ... Hydrolysis at 200 °C in sulfuric acid, it converts to 1-naphthol. The sulfonic acid derivatives of 1-naphthylamine are used for ...
*  N,N-Dimethyl-1-naphthylamine
... is used in the nitrate reductase test to form a red precipitate of Prontosil by reacting with a ... N,N-Dimethyl-1-naphthylamine is an aromatic amine. It is formally derived from 1-naphthylamine by replacing the hydrogen atoms ... "N,N-dimethylnaphthalen-1-amine". ChemSpider. Retrieved 15 April 2010. "D4011 N,N-Dimethyl-1-naphthylamine, ≥98.0% (GC)". Sigma- ...
*  Aptiganel
1994 Jul;38(1):33-8. PMID 7946934 Schäbitz WR, Li F, Fisher M. The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral ... 1-Naphthylamine is reacted with cyanogen bromide to give 2. Treatment of this intermediate with 3-ethyl-N-methylaniline leads ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. Journal of ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: A new, selective noncompetitive NMDA receptor antagonist". Journal of ...
*  N-(1-Naphthyl)ethylenediamine
However, it is a weaker bidentate ligand as the nitrogen atom in the naphthylamine group is weakly coordinating due to the ... ethylenediamine undergoes most reactions typical to naphthylamine and primary amines such as diazotation. Similar to its analog ... N-(1-Naphthyl)ethylenediamine, also called a 'Griess reagent' is an organic compound. It is commercially available and finds ... This compound can be prepared by the reaction of 1-naphthylamine with 2-chloroethanamine. It is commercially available as the ...
*  2-Naphthylamine
... is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. It also can ... 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. It is activated ... 2-Naphthylamine is one of two isomeric aminonaphthalenes, compounds with the formula C10H7NH2. It is a colorless solid, but ... When reduced by sodium in boiling amyl alcohol solution, it forms tetrahydro-3-naphthylamine, which exhibits the properties of ...
*  Sudan Black B
Sudan Black is formed by coupling of diazotized 4-phenylazo-1-naphthylamine with 2,3-dihydro-2,2-dimethyl-1H-perimidine. ... Therefore the main product expected was 2,3-dihydro-2,2dimethyl-6-[(4-phenylazo-1-naphthalenyl)-azo]-1H-perimidine. However the ... HISTOCHEMISTRY AND CELL BIOLOGY Volume 16, Number 1 (1968), 68-84, DOI: 10.1007/BF00306212 Thin layer chrornatography and ... 1, SiO2) in thin Layer Chromatography). The above described product indeed turned out to be SSB-II which comprises up to 60% of ...
*  Nile blue
For better differentiation, it is dipped in 1% acetic acid for 10-20 minutes until the colors are pure. This might take only 1- ... 73 (1): 32-8. doi:10.1562/0031-8655(2001)073. 2.0.CO;2. PMID 11202363. Kanitz, Andreas; Hartmann, Horst (1999). "Preparation ... The Nile blue staining, according to Kleeberg, uses the following chemicals: Nile Blue A 1% acetic acid Glycerol or glycerol ... 2-nitrosophenols with 1-naphthylamine, 3-(dialkylamino)phenols with N-alkylated 4-nitroso-1-naphtylamines, or N,N-dialkyl-1,4- ...
*  NNE1
243: 1-13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262. Antoni R. Blaazer; et al. (October 2011). "Novel indole and ... It is suspected that metabolic hydrolysis of the amide group of NNE1 may release 1-naphthylamine, a known carcinogen, given the ... January 2015). "A case of death caused by abuse of a synthetic cannabinoid N -1-naphthalenyl-1-pentyl-1H -indole-3-carboxamide ... New Zealand Government Gazette, Notice Number 7051, 1 November 2012 Chizuko Sasaki; et al. ( ...
*  C12H13N
The molecular formula C12H13N (molar mass: 171.24 g mol−1, exact mass: 171.10480) may refer to: The drug rasagiline The dye N,N ... 1-naphthylamine More than 400 other chemical compounds "Empirical formula search for C12H13N". ChemSpider. Retrieved 15 April ...
*  MN-18
... it is suspected that metabolic hydrolysis of the amide group of MN-18 may release 1-naphthylamine, a known carcinogen. MN-18 ...
*  Michler's ketone
Condensation of Michler's ketone with N-phenyl-1-naphthylamine gives the dye Victoria Blue B (CAS#2580-56-5, CI Basic Blue 26 ... Charles D. DeBoer, Nicholas J. Turro, and George S. Hammond (1973). "cis- and trans-1,2-Divinylcyclobutane". Organic Syntheses ... absorbs intensely at 366 nm and effectively sensitizes photochemical reactions such as the dimerization of butadiene to give 1, ...
*  5F-NNE1
5F-ADBICA 5F-SDB-006 AM-2201 FDU-NNE1 FUB-144 FUB-NNE1 MMB-2201 NNE1 PX-1 "5F-NNEI". Southern Association of Forensic ... it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen. ...
*  List of MeSH codes (D04)
2-naphthylamine MeSH D04.615.638.870 --- 1-naphthylisothiocyanate MeSH D04.615.638.900 --- naphthylvinylpyridine MeSH D04.615. ... vitamin k 1 MeSH D04.615.638.721.374.844 --- vitamin k 2 MeSH D04.615.638.721.374.922 --- vitamin k 3 MeSH D04.615.638.845 --- ... 10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 --- methylcholanthrene MeSH D04.615.149.700 --- perylene MeSH D04.615. ... 1-naphthylamine MeSH D04.615.638.845.800 --- sertraline MeSH D04.615.638.850 --- ...
*  Alpha-Naphthylthiourea
Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 260 Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide ... Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V16 987 (1995) Cunningham, A. L., and J. V. Hurley. "Alpha‐ ... 1981., p. 1-2 NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases. U.S. Department of Health & Human Services, ... The usual method is the reaction of 1-naphthylamine hydrochloride with ammonium thiocyanate: [C10H7NH3]Cl + NH4SCN → C10H7NHC(S ...
*  Tametraline
4-tetrahydro-2-naphthylamine) Cyproheptadine [4-(5H-dibenz-[a,d]cyclohepten-5-ylidine)-1-methylpiperidine] Dasotraline ... This was the reason why sertraline was made only as monomethylated because apparently according to the orders the 1° amine is ... "A facile one-pot synthesis of 1-amino-4-aryl-tetralin derivatives by the CAN-induced (see also: CAN) cyclodimerization of ... Sarges, R; Koe, BK; Weissman, A; Schaefer, JP (December 1974). "Blockade of Heart 3H-Norepinephrine Up-take by 4-Phenyl-1- ...
*  List of designer drugs
... naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects ... 1P-ETH-LAD, 1-Propionyl-ETH-LAD 1P-LSD, 1-Propionyl-LSD ALD-52, 1-Acetyl-LSD AL-LAD, 6-Allyl-6-Nor-LSD ETH-LAD, 6-Ethyl-6-Nor- ... 32 (1): 41-51. doi:10.1007/s12020-007-9005-2. PMID 17992601. Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). " ... 27: 1-21. doi:10.1162/jocn_a_00776. PMID 25591060. The present meta-analysis was conducted to estimate the magnitude of the ...
*  2-Amino-1,2-dihydronaphthalene
2-Aminoindane 2-Aminotetralin 2-Naphthylamine Hathaway BA, Nichols DE, Nichols MB, Yim GK (May 1982). "A new, potent, ... 2-Amino-1,2-dihydronapthalene (2-ADN), also known as 2-aminodilin (2-AD), is a stimulant drug. It is a rigid analogue of ... It is closely related to 2-aminotetralin (2-amino-1,2,3,4-tetrahydronaphthalene), which also substitutes for amphetamine, and ... conformationally restricted analogue of amphetamine: 2-amino-1,2-dihydronaphthalene". Journal of Medicinal Chemistry. 25 (5): ...
*  Cuthbert Dukes
Boyland E, Dukes CE, Grover PL (1963). "Carcinogenicity of 2-naphthylhydroxylamine and 2-naphthylamine". British Journal of ... 1 (6): 413-23. doi:10.1007/BF02633407. PMID 13609489. Dukes CE, Bussey HJ (1958). "The spread of rectal cancer and its effect ... 17 (1): 79-84. doi:10.1038/bjc.1963.12. PMC 2071273 . PMID 14014726. Boyland E, BUSBY ER, Dukes CE, Grover PL, Manson D (1964 ... 4 (1): 24-37. PMC 2238269 . PMID 18107178. Dukes CE (1949). "The significance of the unusual in the pathology of intestinal ...
*  List of IARC Group 3 carcinogens
Phenelzine sulfate Phenicarbazide Phenol Phenylbutazone meta-Phenylenediamine para-Phenylenediamine N-Phenyl-2-naphthylamine ... 9 Dapsone Decabromodiphenyl oxide Deltamethrin Diacetylaminoazotoluene Diallate 1,2-Diamino-4-nitrobenzene 1,4-Diamino-2- ... 1-Aziridinyl)ethanol Aziridyl benzoquinone Azobenzene 11H-Benz[bc]aceanthrylene Benz[l]aceanthrylene Benz[a]acridine Benz[c] ... 1,5-Naphthalenediamine 1,5-Naphthalene diisocyanate Naphtho[1,2-b]fluoranthene Naphtho[2,1-a]fluoranthene Naphtho[2,3-e]pyrene ...
*  List of IARC Group 1 carcinogens
2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... 2-naphthylamine) Bis(chloromethyl)ether Chloromethyl methyl ether 1,3-Butadiene 1,4-Butanediol dimethanesulfonate (Busulphan, ... 2-Naphthylamine Neutron radiation Nickel compounds2 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) N- ... The Working Group concluded that acetaldehyde associated with alcohol consumption is carcinogenic to humans (Group 1) and ...
*  3-Dimethylaminoacrolein
The amidine formed with 2-naphthylamine and the dimethyl sulfate adduct can be cyclized with sodium methoxide to give benzo[f] ... 5 (1): pp. 10-13, doi:10.5923/j.ajoc.20150501.02 EP 0731094, H.-J. Wroblowsky, R. Lantzsch, "Verfahren zur Herstellung von ... The vinamidinium salt 1,1,5,5-tetramethyl-1,5-diazapentadienium chloride reacts with heterocycles bearing CH-acidic groups to ... The same vinamidinium salt 1,1,5,5-tetramethyl-1,5-diazapentadienium chloride is also formed in the reaction of 3- ...
*  Bucherer reaction
The Bucherer reaction in organic chemistry is the reversible conversion of a naphthol to a naphthylamine in the presence of ... The enamine eliminates sodium bisulfite with formation of naphthylamine 6. It is important to stress that this is a reversible ... in German). 69 (1): 49-91. doi:10.1002/prac.19040690105. Seeboth, Habil H. (1967). "The Bucherer Reaction and the Preparative ... 1. pp. 63-90. doi:10.1002/0471264180.or001.05. ISBN 9780471264187. Pötsch, Winfried R.; Fischer, Annelore; Müller, Wolfgang ( ...
*  Victoria blue BO
Victoria blues are members of the triarylmethane dyes, but unlike most such dyes, the Victoria blues have an naphthylamine ... Victoria Blue BO base, also known as Solvent Blue 5 and C.I. 42595:1, is the hydroxide derivative of the same cation. Its ...
*  NOBIN
... is prepared by oxidative cross coupling of 2-naphthol and 2-naphthylamine. The oxidative source is metal ions in solution ... NOBIN (2-amino-2'-hydroxy-1,1'-binaphthyl) is an organic molecule used for asymmetric catalysis. NOBIN is related to BINOL and ...
*  Induline
... rosinduline from benzeneazo-a-naphthylamine and aniline and naphthinduline from benzeneazo-a-naphthylamine and naphthylamine. ... Isorosinduline is obtained from quinone dichlorimide and phenyl-13-naphthylamine; ... The indulines may be subdivided into the following groups: (1) benzindulines, derivatives of phenazine; (2) isorosindulines; ...
*  Ivan Ostromislensky
He also proposed organic additions to rubber, such as toluidine and naphthylamine, in order to improve its properties. Those ... ISBN 1-931968-53-5. Rudolph D. Deanin (1987). History of Polymeric Composites. VSP. p. 327. ISBN 90-6764-082-4. Остромысленский ... He had patented more than 20 ways to produce butadiene (buta-1,3-diene), which were implemented industrially in the Soviet ...
N-Phenyl-2-naphthylamine  (IARC Summary & Evaluation, Supplement7, 1987)  N-Phenyl-2-naphthylamine (IARC Summary & Evaluation, Supplement7, 1987)
Phenyl-2-naphthylamine *Phenyl(b-naphthyl)amine *Phenyl-b-naphthylamine *N-Phenyl-b-naphthylamine *Stabilizator AR Last updated ... to N-phenyl-2-naphthylamine was found to contain 2-naphthylamine, indicating that N-phenyl-2-naphthylamine is dephenylated in ... of a single 10-mg dose of N-phenyl-2-naphthylamine is converted to 2-naphthylamine. Similarly, the urine of workers exposed ... N-Phenyl-2-naphthylamine is not classifiable as to its carcinogenicity to humans (Group 3). For definition of the italicized ...
more infohttp://inchem.org/documents/iarc/suppl7/nphenyl2naphthylamine.html
N-Phenyl-2-Naphthylamine (IARC Summary & Evaluation, Volume 16, 1978)  N-Phenyl-2-Naphthylamine (IARC Summary & Evaluation, Volume 16, 1978)
N-PHENYL-2-NAPHTHYLAMINE. VOL.: 16 (1978) (p. 325) 5. Summary of Data Reported and Evaluation1. 5.1 Animal data. N-Phenyl-2- ... In one study, in one factory, of men with known exposure to N-phenyl-2-naphthylamine in rubber processing under controlled ... In the latter study, exposure was mixed but probably included exposure to N-phenyl-2-naphthylamine for many workers. These ... However, a broader study of rubber workers who had no exposure to 2-naphthylamine has shown an increased risk of bladder ...
more infohttp://inchem.org/documents/iarc/vol16/nphenylnaphthylamine.html
1-Naphthylamine - Wikipedia  1-Naphthylamine - Wikipedia
... the naphthylamine steam-distilled. It can also be prepared, in the form of its acetyl derivative, by heating 1-naphthol with ... 1-Naphthylamine is an aromatic amine derived from naphthalene.It can cause Bladder Cancer. It crystallizes in colorless needles ... It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid at about 70 °C. After the reaction mixture is ... Hydrolysis at 200 °C in sulfuric acid, it converts to 1-naphthol. The sulfonic acid derivatives of 1-naphthylamine are used for ...
more infohttps://en.wikipedia.org/wiki/1-Naphthylamine
N,N-Dimethyl-1-naphthylamine - Wikipedia  N,N-Dimethyl-1-naphthylamine - Wikipedia
N,N-Dimethyl-1-naphthylamine is used in the nitrate reductase test to form a red precipitate of Prontosil by reacting with a ... N,N-Dimethyl-1-naphthylamine is an aromatic amine. It is formally derived from 1-naphthylamine by replacing the hydrogen atoms ... "N,N-dimethylnaphthalen-1-amine". ChemSpider. Retrieved 15 April 2010. "D4011 N,N-Dimethyl-1-naphthylamine, ≥98.0% (GC)". Sigma- ...
more infohttps://en.wikipedia.org/wiki/N,N-Dimethyl-1-naphthylamine
N-(Iodoacetaminoethyl)-1-naphthylamine-5-sulfonic acid | Sigma-Aldrich  N-(Iodoacetaminoethyl)-1-naphthylamine-5-sulfonic acid | Sigma-Aldrich
... naphthylamine-5-sulfonic acid products. View information & documentation regarding N-(Iodoacetaminoethyl ... naphthylamine-5-sulfonic acid, including CAS, MSDS & more. ... Synonym: 1,5-I-AEDANS, 5-. [2-. (Iodoacetamido). ethylamino]. naphthalene-. 1-. sulfonic acid, N-Iodoacetyl-N′-(5-sulfo-1- ... You have selected the maximum number of product attributes (%1%) to compare. Please remove at least one to add a new selection. ...
more infohttps://www.sigmaaldrich.com/catalog/substance/niodoacetaminoethyl1naphthylamine5sulfonicacid434253693063911?lang=en®ion=US
producer n phenyl 1 naphthylamine  producer n phenyl 1 naphthylamine
N-Phenyl-Alpha Naphthylamine - Phenyl Alpha Naphthylamine .. On offer from us is Phenyl Alpha Naphthylamine Chemical, which is ... N-Phenyl-2-naphthylamine , C16H13N - PubChem. Using an initial concn of 100 mg/L N-phenyl-2-naphthylamine, 0 %BOD was observed ... 2-Naphthylamine-8- Hydroxy-6-Sulfonic Acid . 239 : C 10 H 9 N 1 O 4 S 1: Intermediates for Dyestuffs : Laurent's Acid 1- ... N-(2-Dimethylaminoethyl)-N-Ethyl-M-Toluidine ; TOLUZONE BASE: 36790-28-0: 4-CHLORO RESORCINOL (4CRN) 95-88-5: 2-Naphthylamine-4 ...
more infohttps://steunmijnclub.nl/506_producer-n-phenyl-1-naphthylamine.html
1-NAPHTHYLAMINE (1-AMINONAPHTHALENE)  1-NAPHTHYLAMINE (1-AMINONAPHTHALENE)
Naphthylamine is the naphthalene homologues of aniline. Naphthylamine is the starting material in the dye manufacturing and ... Naphthylamine is an aromatic amine which can be obtained from nitronaphthalene (with iron and hydrochloric acid) or naphthol ... Naphthylamine can be oxidized by chromic acid into naphthoquinone which is the fundamental ring structure related with vitamin ... 2-Naphthylamine was used as an Intermediate for wide application target molecules including dyestuffs, agrochemicals, and ...
more infohttp://www.chemicalland21.com/specialtychem/finechem/1-NAPHTHYLAMINE.htm
1-Naphthylamine hydrochloride | 552-46-5  1-Naphthylamine hydrochloride | 552-46-5
You can also browse global suppliers,vendor,prices,Price,manufacturers of 1-Naphthylamine hydrochloride(552-46-5). At last,1- ... Naphthylamine hydrochloride(552-46-5) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need. ... Visit ChemicalBook To find more 1-Naphthylamine hydrochloride(552-46-5) information like chemical properties,Structure,melting ... 1-Naphthylamine hydrochloride. CAS No.. 552-46-5. Chemical Name:. 1-Naphthylamine hydrochloride. Synonyms. 1-NaphthylamineHCl;1 ...
more infohttps://www.chemicalbook.com/ChemicalProductProperty_EN_CB1695553.htm
N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid | CAS 36930-64-0 | SCBT - Santa Cruz Biotechnology  N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid | CAS 36930-64-0 | SCBT - Santa Cruz Biotechnology
8-Naphthylamine-1-Sulfonic Acid (CAS 36930-64-0), a fluorescent thiol-reactive reagent, from Santa Cruz Biotechnology. ... N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid (CAS 36930-64-0) *bvseo_sdk, java_sdk, bvseo-3.2.0 ... N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid A fluorescent thiol-reactive reagent *Home. ... N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid is a fluorescent sulfhydryl reagent that is sensitive to photo ...
more infohttps://www.scbt.com/scbt/product/n-iodoacetylaminoethyl-8-naphthylamine-1-sulfonic-acid-36930-64-0/
1-Naphthylamine hydrochloride 552-46-5 Route Of Synthesis   Synthetic Routes  1-Naphthylamine hydrochloride 552-46-5 Route Of Synthesis Synthetic Routes
1-Naphthylamine hydrochloride 552-46-5 route of synthesis, 1-Naphthylamine hydrochloride chemical synthesis methods, 1- ... Current Page: Home › Chemical Dictionary › 552-46-5 › 1-Naphthylamine hydrochloride 552-46-5 Synthesis Route ... 1-Naphthylamine hydrochloride 552-46-5 Synthesis RouteTotal: 4 Synthesis Route ...
more infohttp://www.molbase.com/en/synthesis_552-46-5-moldata-4138.html
1-Naphthylamine-7-sulfonic acid 119-28-8 MSDS, Safety Technical Specifications   MSDS  1-Naphthylamine-7-sulfonic acid 119-28-8 MSDS, Safety Technical Specifications MSDS
1-Naphthylamine-7-sulfonic acid 119-28-8 MSDS report, 1-Naphthylamine-7-sulfonic acid MSDS safety technical specifications ... search, 1-Naphthylamine-7-sulfonic acid safety information specifications ect. ... 1-Naphthylamine-7-Sulfonic Acid 100 204-311-4 Hazard Symbols: XI Risk Phrases: 36/38 Section 3 - HAZARDS IDENTIFICATION. ... 1-Naphthylamine-7-Sulfonic Acid - Not listed by ACGIH, IARC, or NTP.. Section 12 - ECOLOGICAL INFORMATION. Section 13 - ...
more infohttp://www.molbase.com/en/msds_119-28-8-moldata-22739.html
606-57-5, 1-nitro-2-naphthylamine, CAS No 606-57-5 1-nitro-2-naphthylamine nl  606-57-5, 1-nitro-2-naphthylamine, CAS No 606-57-5 1-nitro-2-naphthylamine nl
1-nitro-2-naphthylamine ; physical and chemical property of 606-57-5, 1-nitro-2-naphthylamine is provided by ChemNet.com ... 2-Naphthylamine, 1-nitro-; 1-Nitro-2-naphthylamine; 2-Amino-1-nitronaphthalene; 4-12-00-03184 (Beilstein Handbook Reference); ... CAS No: 606-57-5, Chemical Name: 1-nitro-2-naphthylamine. Home , Products , Suppliers , Offer to Buy , Offer to Sell , Chemical ... Gold Suppliers(1):. 1Hebei Smart Chemicals (Group) Co. Ltd.. Related selling offers. ...
more infohttp://www.chemnet.com/cas/nl/606-57-5/1-nitro-2-naphthylamine.html
N-ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine - Substance Information - ECHA  N-ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine - Substance Information - ECHA
2-naphthylamine. ↓Other names: Regulatory process names [2] IUPAC names [2] ... N-Ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine * N-ethyl-1-[(E)-2-{4-[(E)-2-phenyldiazen-1-yl]phenyl}diazen-1-yl]naphthalen ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ...
more infohttps://echa.europa.eu/substance-information/-/substanceinfo/100.026.238
ChemIDplus - 31209-75-3 - KJTTXCHPHDCOQD-UHFFFAOYSA-N - 2-Naphthylamine, 1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-,...  ChemIDplus - 31209-75-3 - KJTTXCHPHDCOQD-UHFFFAOYSA-N - 2-Naphthylamine, 1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-,...
1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride - Similar structures search, synonyms, formulas, resource links, ... Substance Name: 2-Naphthylamine, 1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride. RN: 31209-75-3. InChIKey: ... 1S/C20H25N.ClH/c1-19(2)15-20(21-3,13-16-9-5-4-6-10-16)14-17-11-7-8-12-18(17)19;/h4-12,21H,13-15H2,1-3H3;1H. Download. ...
more infohttps://chem.nlm.nih.gov/chemidplus/rn/31209-75-3
AID 752868 - Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as...  AID 752868 - Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as...
Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr ...
more infohttps://pubchem.ncbi.nlm.nih.gov/bioassay/752868
1-o-tolylazo-2-naphthylamine - albumin  1-o-tolylazo-2-naphthylamine - albumin
Prediction : 1-o-tolylazo-2-naphthylamine - albumin. Your feedback has been submited, thank you! ... 5-acetoxy-1-benzyl-2-methyl-indole-3-carboxylic-acid-ethyl-ester-albumin.html ... The value ranges from 0 to 1, with 1 being identical to the original X-Ray compound. ...
more infohttp://albumin.althotas.com/predictions/1-o-tolylazo-2-naphthylamine-albumin.html
PB-22 4-hydroxyisoquinoline isomer- CAS Number null  PB-22 4-hydroxyisoquinoline isomer- CAS Number null
N-Phenyl-2-naphthylamine. 10 mg. LGCFOR2550.00. Add to basket Pamaquine Naphthoate. 5 mg. LGCFOR1437.00. Add to basket ... 1 mL. LGCAMP2115.00-01. Add to basket 2-Phenylethylamine Hydrochloride (Phenethylamine Hydrochloride, PEA HCl). 10 mg. ... 1 mL. LGCAMP1275.47-01. Add to basket 7,7',8,8'-Tetradehydro-4,5alpha:4',5'alpha-diepoxy-17,17'-dimethyl-2,2'-bimorphinanyl-3,3 ... N-Phenyl-1-naphthylamine. 10 mg. LGCFOR2549.00. Add to basket ... 1 mL. LGCAMP1275.57-01. Add to basket Perazine Dimaleate. 10 mg ...
more infohttps://www.lgcstandards.com/ES/en/PB-22-4-hydroxyisoquinoline-isomer/p/CAY-14554-1MG
Papaverine- CAS Number 58-74-2  Papaverine- CAS Number 58-74-2
N-Phenyl-2-naphthylamine. 10 mg. LGCFOR2550.00. Add to basket Pamaquine Naphthoate. 5 mg. LGCFOR1437.00. Add to basket ... 1 mL. LGCAMP2115.00-01. Add to basket 2-Phenylethylamine Hydrochloride (Phenethylamine Hydrochloride, PEA HCl). 10 mg. ... 1 mL. LGCAMP1275.47-01. Add to basket 7,7',8,8'-Tetradehydro-4,5alpha:4',5'alpha-diepoxy-17,17'-dimethyl-2,2'-bimorphinanyl-3,3 ... N-Phenyl-1-naphthylamine. 10 mg. LGCFOR2549.00. Add to basket ... 1 mL. LGCAMP1275.57-01. Add to basket Perazine Dimaleate. 10 mg ...
more infohttps://www.lgcstandards.com/FR/en/Papaverine/p/CAY-10011133-500MG
China Mixed Aromatics, Mixed Aromatics Manufacturers, Suppliers | Made-in-China.com  China Mixed Aromatics, Mixed Aromatics Manufacturers, Suppliers | Made-in-China.com
N-Phenyl-1-Naphthylamine CAS 90-30-2 FOB Price: US $ 5100-5300 / Ton. Min. Order: 1 Ton ... Smart Drug 9-Fluorenol CAS 1689-64-1 for Memory Improve FOB Price: US $ 1-3 / Piece. Min. Order: 10 Pieces ...
more infohttps://www.made-in-china.com/products-search/hot-china-products/Mixed_Aromatics.html
  • On offer from us is Phenyl Alpha Naphthylamine Chemical, which is used in the chemical industry as an intermediate for dyestuff and food colors.Processed under the strict supervision of our deft auditors, we have take intense care to match the purity standards of the industry. (steunmijnclub.nl)
  • You have selected the maximum number of product attributes (%1%) to compare. (sigmaaldrich.com)
  • Numerous sulfo- and nitro-group substituted naphthylamine on the ring system offer important roles to each characteristic colours directly and in preparing next target colorants. (chemicalland21.com)
  • 1. Any insoluble material which separates on conversion into the sodium salt is toluamide , which may be isolated. (orgsyn.org)
  • 2. A recording element according to claim 1 wherein said layer of amorphous material has a thickness of less than 0.45 micron. (google.com)
  • 3. A recording element according to claim 1 wherein said amorphous material is organic solvent-soluble. (google.com)
  • 5. A recording element according to claim 1 wherein said support is a reflecting support and is coated on both sides with a layer of said amorphous material. (google.com)
  • 2-Naphthylamine was used as an Intermediate for wide application target molecules including dyestuffs, agrochemicals, and antioxidants. (chemicalland21.com)