A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.
A naphthalene derivative with carcinogenic action.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Organic compounds that contain the (-NH2OH) radical.
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.
Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).
Tumors or cancer of the URINARY BLADDER.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro. (1/96)

We previously demonstrated (M. M. Exner, P. Doig, T. J. Trust, and R. E. W. Hancock, Infect. Immun. 63:1567-1572, 1995) that Helicobacter pylori has at least one nonspecific porin, HopE, which has a low abundance in the outer membrane but forms large channels. H. pylori is relatively susceptible to most antimicrobial agents but less susceptible to the polycationic antibiotic polymyxin B. We demonstrate here that H. pylori is able to take up higher basal levels of the hydrophobic fluorescent probe 1-N-phenylnaphthylamine (NPN) than Pseudomonas aeruginosa or Escherichia coli, consistent with its enhanced susceptibility to hydrophobic agents. Addition of polymyxin B led to a further increase in NPN uptake, indicative of a self-promoted uptake pathway, but it required a much higher amount of polymyxin B to yield a 50% increase in NPN uptake in H. pylori (6 to 8 microg/ml) than in P. aeruginosa or E. coli (0.3 to 0.5 microg/ml), suggesting that H. pylori has a less efficient self-promoted uptake pathway. Since intrinsic resistance involves the collaboration of restricted outer membrane permeability and secondary defense mechanisms, such as periplasmic beta-lactamase (which H. pylori lacks) or efflux, we examined the possible role of efflux in antibiotic susceptibility. We had previously identified in H. pylori 11637 the presence of portions of three genes with homology to potential restriction-nodulation-division (RND) efflux systems. It was confirmed that H. pylori contained only these three putative RND efflux systems, named here hefABC, hefDEF, and hefGHI, and that the hefGHI system was expressed only in vivo while the two other RND systems were expressed both in vivo and in vitro. In uptake studies, there was no observable energy-dependent tetracycline, chloramphenicol, or NPN efflux activity in H. pylori. Independent mutagenesis of the three putative RND efflux operons in the chromosome of H. pylori had no effect on the in vitro susceptibility of H. pylori to 19 antibiotics. These results, in contrast to what is observed in E. coli, P. aeruginosa, and other clinically important gram-negative bacteria, suggest that active efflux does not play a role in the intrinsic resistance of H. pylori to antibiotics.  (+info)

Effect of polymorphisms on ligand binding by mouse major urinary proteins. (2/96)

Mouse urine contains an abundance of major urinary proteins, lipocalins, whose roles include slow release of semiochemicals. These proteins are highly polymorphic, with small sequence differences between individual members. In this study, we purified to homogeneity four of these proteins from two strains of inbred mice and characterized them by mass spectrometry. This analysis has led to the discovery of another variant in this group of proteins. Three of the polymorphic variants that map to the surface have no effect on the binding of a fluorescent probe in the binding cavity, but the fourth, characterized by a Phe to Val substitution in the cavity, shows a substantially lower affinity and fluorescence yield for the probe. These results are interpreted in light of the known crystal structure of the protein and molecular modeling calculations, which rationalize the experimental findings. This work raises the possibility that the calyx-binding site can show specificity for different ligands, the implications of which on pheromone binding and chemical communication are discussed.  (+info)

The micronucleus assay in human exfoliated urothelial cells: application in a genotoxicity study of workers exposed to a mineral jelly containing sodium nitrite and N-phenyl-1-naphthylamine. (3/96)

Exposure to certain chemical agents in occupational settings has been identified as carcinogenic to the human bladder. Micronucleus (MN) analysis in exfoliated urothelial cells is an interesting method for biomonitoring genetic damage in human populations. However, few studies have been performed in an occupational context. The aim of this study was to examine whether the occupational use of a mineral jelly induced a genotoxic risk for workers employed at a single factory producing bearings using the MN test on exfoliated urothelial cells. The prevalence of micronucleated exfoliated urothelial cells (MNC) was determined in 35 female workers with dermal exposure to the jelly and 41 female controls. The mean percentage of MNC (expressed as percent cells with MN per 1000 cells scored) observed in the exposed worker group was 0.46 +/- 0.11% (range 0-2.8) and in the control group 0.14 +/- 0.03% (range 0-0.8). There is a significant job effect (P = 0.0018, MANCOVA) on the prevalence of MNC, whereas age and smoking habit had no significant effect (P = 0.90 and 0.91, respectively). There is no interaction between job and smoking habit (P = 0.4421). Exposure to the mineral jelly appeared to be the main factor inducing the increased prevalence of MNC. This may be due to the presence of mutagens/carcinogens in the jelly: an aromatic amine, N-phenyl-1-naphthylamine (CAS no. 90-30-2), which is carcinogenic in mice, or sodium nitrite (CAS no. 7632-00-0), which is genotoxic in human cell systems. In conclusion, these results suggest that use of the mineral jelly could present a genotoxic risk for workers. We think that the MN assay on exfoliated cells could be valuable for biological monitoring purposes in occupational contexts as a marker of significant exposure to bladder mutagenic/carcinogenic agents.  (+info)

Specific interactions of the antimicrobial peptide cyclic beta-sheet tachyplesin I with lipopolysaccharides. (4/96)

The cyclic beta-sheet antimicrobial peptide tachyplesin I (T-SS) was found to show 280-fold higher affinity for lipopolysaccharides (LPS) compared with acidic phospholipids, whereas the linear alpha-helical peptide F5W-magainin 2 (MG2) could not discriminate between LPS and acidic phospholipids. The recognition site was the lipid A moiety and the cyclic structure was crucial to this specific binding. The cyclic structure also endowed the peptide with very rapid outer membrane (OM) permeabilization.  (+info)

Rhamnolipid stimulates uptake of hydrophobic compounds by Pseudomonas aeruginosa. (5/96)

The biodegradation of hexadecane by five biosurfactant-producing bacterial strains (Pseudomonas aeruginosa UG2, Acinetobacter calcoaceticus RAG1, Rhodococcus erythropolis DSM 43066, R. erythropolis ATCC 19558, and strain BCG112) was determined in the presence and absence of exogenously added biosurfactants. The degradation of hexadecane by P. aeruginosa was stimulated only by the rhamnolipid biosurfactant produced by the same organism. This rhamnolipid did not stimulate the biodegradation of hexadecane by the four other strains to the same extent, nor was degradation of hexadecane by these strains stimulated by addition of their own biosurfactants. This suggests that P. aeruginosa has a mode of hexadecane uptake different from those of the other organisms. Rhamnolipid also enhanced the rate of epoxidation of the aliphatic hydrocarbon alpha,omega-tetradecadiene by a cell suspension of P. aeruginosa. Furthermore, the uptake of the hydrophobic probe 1-naphthylphenylamine by cells of P. aeruginosa was enhanced by rhamnolipid, as indicated by stopped-flow fluorescence experiments. Rhamnolipid did not stimulate the uptake rate of this probe in de-energized cells. These results indicate that an energy-dependent system is present in P. aeruginosa strain UG2 that mediates fast uptake of hydrophobic compounds in the presence of rhamnolipid.  (+info)

Effect of EDTA on Salmonella enterica serovar Typhimurium involves a component not assignable to lipopolysaccharide release. (6/96)

The effect of EDTA on Salmonella enterica serovar Typhimurium was studied in different growth phases with cells grown with or without Ca(2+) and Mg(2+) supplementation. EDTA affected the outer membrane much more strongly in the early exponential phase than in the mid- or late exponential phase, as indicated by uptake of 1-N-phenylnaphthylamine (a nonpolar hydrophobic probe, M(r) 219), and detergent (SDS) susceptibility. This effect was, however, not paralleled by LPS release (determined by measuring LPS-specific fatty acids or 14C-labelled LPS in cell-free supernatants, per a standardized cell density), which remained unchanged as a function of the growth curve. The conclusion from these results is that in the early exponential phase the effect of EDTA in S. enterica involves a component that is independent of LPS release.  (+info)

Neuroendocrine response to clonidine and 8-OH-DPAT in rats following chronic administration of desipramine or sertraline. (7/96)

1. Rats were administered either desipramine (DMI) or sertraline daily at doses 7.5 mg kg-1 or 10 mg kg-1, i.p., respectively and the effects on the functional state of hypothalamic neuroendocrine control mechanisms assessed by measurements of plasma hormones following acute drug challenge. The effects of treatment on gross behaviour and brain adrenoceptor density were also determined. 2. Both DMI and sertraline caused significant reduction in activity measured as ambulation and rearing at 14 days of treatment. 3. All animals were chronically cannulated after 14 days of treatment and tested for neuroendocrine response to acute i.v. clonidine (50 micrograms kg-1) or 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 250 micrograms kg-1) after 21 or more days of treatment. 4. Rats treated with DMI but not sertraline showed a virtually complete suppression of the growth hormone (GH) secretion elicited by clonidine in controls, while the secretion of corticosterone was augmented. 5. Treatment with DMI but not sertraline led to a significantly greater 8-OH-DPAT-induced secretion of prolactin than in the control rats, while the plasma concentrations of corticosterone following 8-OH-DPAT were not influenced by either DMI or sertraline treatment. 6. The density (but not the affinity) of cerebral cortical binding of [3H]-dihydroalprenolol was significantly reduced by DMI treatment. 7. These results show that DMI treatment blunted the sensitivity of post-synaptic alpha 2-adrenoceptors, accompanied by complex interactions manifested as increased responsiveness of alpha 1-adrenoceptors and 5-HT1A receptors. Sertraline had no significant neurendocrine effects at a dose which significantly reduced gross activity.  (+info)

The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. (8/96)

Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs might inhibit CYP2D6, the effects of five SSRIs on human liver microsomal CYP2D6 activity were compared with each other and with three tricyclic antidepressant drugs. On a molar basis, paroxetine was the most potent of the SSRIs at inhibiting the CYP2D6-catalysed oxidation of sparteine (Ki = 0.15 microM), although fluoxetine (0.60 microM) and sertaline (0.70 microM) had Ki values in the same range. Fluvoxamine (8.2 microM) and citalopram (5.1 microM) also inhibited CYP2D6 activity. The major circulating metabolites of paroxetine in man produced negligible inhibition. In contrast, norfluoxetine the active metabolite of fluoxetine, was a potent CYP2D6 inhibitor (0.43 microM). CYP2D6 activity was also diminished by the tricyclic antidepressant drugs clomipramine (2.2 microM), desipramine (2.3 microM) and amitriptyline (4.0 microM). These findings suggest that compounds with SSRI activity are likely to interact with human CYP2D6 in vivo with the potential of causing drug interactions.  (+info)

Chem. Abstr. Name: N-Phenyl-2-naphthalenamine A. Evidence for carcinogenicity to humans (inadequate) No excess of bladder tumours was found among men in a rubber processing factory with known exposure to N-phenyl-2-naphthylamine (which contained small amounts of 2-naphthylamine); however, a study of rubber workers who were not exposed to 2-naphthylamine did show an increased incidence of bladder tumours. In the latter study, the men were exposed to several compounds, which probably included N-phenyl-2-naphthylamine [ref: 1]. B. Evidence for carcinogenicity to animals (limited) N-Phenyl-2-naphthylamine was tested for carcinogenicity by oral administration in mice, rats, hamsters and dogs. No carcinogenicity was reported in most experiments [ref: 1-4]. In one experiment, the total tumour incidence and the incidence of hepatocellular tumours were increased in male mice of one strain [ref: 1]. In another experiment, two rare kidney tumours were seen in female mice [ref: 2]. Subcutaneous ...
In one study, in one factory, of men with known exposure to N-phenyl-2-naphthylamine in rubber processing under controlled conditions, there was no indication of an excess incidence of bladder tumours. However, a broader study of rubber workers who had no exposure to 2-naphthylamine has shown an increased risk of bladder tumours. In the latter study, exposure was mixed but probably included exposure to N-phenyl-2-naphthylamine for many workers. These findings do not permit an assessment of the presence or absence of an elevated risk for cancer of the urinary bladder in persons exposed to N-phenyl-2-naphthylamine. 1 Subsequent to the finalization of this evaluation by the Working Group in June 1977, the Secretariat became aware of an abstract of a paper by Checkoway et al. (1977) describing a retrospective cohort mortality study of bladder cancers in 4 major US rubber companies between 1964-1973; however, the study cannot be evaluated on the basis of the data presented.. Subsequent evaluation: ...
N-Phenyl-1-naphthylamine C16H13NN-Phenyl-1-naphthylamines production and use as an antioxidant in various lubrication oils and as both a protective agent and
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Benzamide, 4-bromo-N-(1H-indol-3-ylphenylmethyl)-N-phenyl- | C28H21BrN2O | CID 71399214 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule 6-(cyclohexylmethoxy)-n-phenyl-1h-purin-2-amine (C18H21N5O) from the PQR.
Those results were in agreement with the antimicrobial and hemolytic activities of CODs. Moreover, we found that the studied peptides permeated both the outer and inner cytoplasmic membranes of Escherichia coli. This was determined by measuring changes in the fluorescence of probe N-phenyl-1-naphthylamine and detecting cytoplasmic β-galactosidase released during the interaction of peptides with E. coli cells. Transmission electron microscopy revealed that treatment of E. coli with one of the COD analogs caused leakage of bacterial content mainly from the septal areas of the ...
TY - JOUR. T1 - Spin-crossover in iron(ii) coordination compounds with 2,6-bis(benzimidazol-2-yl)pyridine. AU - Ivanova, A. D.. AU - Korotaev, E. V.. AU - Komarov, V. Yu. AU - Sheludyakova, L. A.. AU - Varnek, V. A.. AU - Lavrenova, L. G.. PY - 2020/4/21. Y1 - 2020/4/21. N2 - New iron(ii) complexes with 2,6-bis(benzimidazol-2-yl)pyridine (L), in particular, [FeL2]A2·nH2O (A = Br- (I), NO3- (II), C2N3- (III); n = 1 (I), 0.5 (II), 2 (III)) and [NiL2]Br2·1.23H2O·3.33EtOH (IV), have been synthesized and studied using single-crystal and powder X-ray diffraction techniques, UV-vis (diffuse reflection), IR and Mössbauer spectroscopy, as well as static magnetic susceptibility measurements. According to the experimental μeff(T) curves all the studied iron(ii) compounds exhibit 1A1 ↔ 5T2 spin-crossover.. AB - New iron(ii) complexes with 2,6-bis(benzimidazol-2-yl)pyridine (L), in particular, [FeL2]A2·nH2O (A = Br- (I), NO3- (II), C2N3- (III); n = 1 (I), 0.5 (II), 2 (III)) and ...
The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
12236-11-2 R 79579 1,3-Dioxane, 2,4-dimethyl-6-phenyl- (3Z)-3-(2-furylmethylidene)-1H-indol-2-one Amines, C12-14-tert-alkyl, bis(4-((5-chloro-2-hydroxyphenyl)azo)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-))cobaltate(1-) (1:1) N-phenyl-6-(tribromomethyl)-1,3,5-triazine-2,4-diamine N-[(chloro-dipropan-2-yloxyphosphoryl-methylidene)amino]-4-methyl-aniline 10,11-dithiocyanatoundecanoic acid Androsol acetate Trihydrogen tris((4-((4-(diethylamino)phenyl)(4-(ethyl(3-sulphonatobenzyl)amino)-o-tolyl)methylene)-3-methylcyclohexa-2,5-dien-1-ylidene)(ethyl)(3-sulphonatobenzyl)ammonium), aluminium salt
NFC is the only domestic producer of PANA (n-phenyl-1-naphthylamine), an anti-oxidant used in synthetic lubricants, rubber products and as an organic intermediate. Three options offered are molten liquid, solid and flake ...
Dr. Jing Zhang, Post-doctoral fellow (2013-16) Novel diagnostic tools for blast trauma, pre-symptomatic acute infectious disease and severe stress. Dr. Diana Campbell, Doctoral thesis (2012-16) Cross-regulation between thyroid and androgen hormones in amphibians. Dr. Sonja Bissegger, Doctoral thesis (2013-16) Role of 5 alpha-reductase type 3 and 5 beta-reductase in reproduction. Melody Kang, NSERC-USRA student (2016) DNA methylation in fish. Marie Sereneo, Honours thesis (2015-16) Effect s of diluted bitumen in rainbow trout. Tyler Rozario, Biotechnology placement student (2016) from St. Lawrence College, Kingston, ON. Giselle Hunt, NSERC-USRA student (2015) Analyzing the effects of dietary N-Phenyl-1-naphthylamine in snapping turtles (Chelydra sepentina). Steven Davis, SWEP student (2015) Animal care facility manager. Sean Chisnell, Biotechnology placement student (2015) from St. Lawrence College, Kingston, ON. Nova Zhao, NSERC-USRA student (2014) Development of in situ hybridization assays to ...
Wet-lab validated real-time PCR primer assays for your biological pathway of interest. Select your gene target of interest using an interactive pathway map, and select your plate.
(2-(4-(2-benzimidazol-2ylthio)ethyl)piperazin-1yl)-N-(2,4-bis(methylthio)-6-methyl-3-pyridyl)acetamide: a selective ACAT-1 inhibitor that suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels; structure in first source
77562-96-0 - BNTJVEIUADBJII-UHFFFAOYSA-N - Propanamide, N-(1-methyl-2-(4-(1-methylethyl)-1-piperazinyl)ethyl)-N-phenyl-, ethanedioate, hydrate (2:4:1) - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Sulfonation products of (N-phenyl-4-[[4-(phenylamino)phenyl][4-(phenylimino)cyclohexa-2,5-dien-1-ylidene]methyl]aniline, monohydrochloride and 4,4-[(4-iminocyclohexa-2,5-dien-1-ylidene)methylene]bis[N-phenylaniline], monohydrochloride), sodium salts ...
Chemical name:N-Phenyl-β-NaphthylamineMolecular formula:C16H13N Molecular structure: Molecular weight:219.29 CAS NO.:135-88-6Executive standard:Q/12HG 4521
Looking for Brönner's acid? Find out information about Brönner's acid. C10H6 SO3H A colorless, water-soluble naphthylamine sulfonic acid that forms needle crystals; used in dyes. Also spelled Broenners acid Explanation of Brönner's acid
good quality strength mineral rack gold ore flotation cell Simply said a Flotation Collectors is a chemical used to make the surface of minerals which is metallic hydrophobic or in layman s term afraid of water or water hating as others like to say This chemical used will behaved in a way as a wax would when you applied it to your car After wax or hydrophobic agent is adhered to Get Price ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Pantoprazole Sodium Sesquihydrate ;. Sodium 5-(difluoromethoxy)-2-[(RS)-[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]benzimidazol-1-ide ;. CAS # 138786-67-1 (anhydrous) ; 164579-32-2 (sesquihydrate) ; 718635-09-7 (hydrate) ;. C16H14F2N3NaO4S (anhydrous) ; MW: 405.35 ;. C16H14F2N3NaO4S . 1.5 H2O ; Mol. Wt.: 432.40. Supplied as sesquihydrate for lab research use (not for human use) ;. ...
Synthesis and biological screening of 5-{[(4,6-disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines, MA Azam, B.R.P Kumar, S Shalini, B Suresh, TK Reddy, C
TY - JOUR. T1 - Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe. AU - Dong, Lei. AU - Zang, Yi. AU - Zhou, Dan. AU - He, Xiao Peng. AU - Chen, Guo Rong. AU - James, Tony D.. AU - Li, Jia. PY - 2015/7/28. Y1 - 2015/7/28. N2 - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.. AB - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.. UR - http://www.scopus.com/inward/record.url?scp=84936970791&partnerID=8YFLogxK. UR - http://dx.doi.org/10.1039/c5cc04357c. U2 - 10.1039/c5cc04357c. DO - ...
No detectable medication was present in any infant exposed to paroxetine or fluvoxamine. Detectable medication (parent and/or metabolite) was present in 24% (8/33) of the serum samples obtained from infants exposed to sertraline. Concentrations of sertraline and desmethylsertraline, when present, were 2-8 and 2-12 ng/ml, respectively.. Four mothers (nos 5, 16, 24 and 49) titrated their dose of the antidepressant upwards to help their mood and obtained repeat serum samples on themselves and their infants after being on the higher medication dosage for at least 1 week.. Maternal dosage of sertraline correlated highly with infant serum concentration of desmethylsertraline after controlling for infant age, gestational exposure and breast-feeding exposure (parameter estimate=0.09, d.f.=1, P=0.03). Maternal serum concentrations of sertraline and desmethylsertraline correlated highly with infant serum concentration of desmethylsertraline (parameter estimate=0.20, d.f.=1, P,0.001 and parameter ...
HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS - diagram, schematic, and image 32 ...
Materials. 17-Allylamino-demethoxygeldanamycin (17-AAG) was provided by the National Cancer Institute and Kosan Biosciences (Hayward, CA). 2,6-Dichlorophenol-indophenol (DCPIP), NADH, NADPH, sodium borohydride, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), bovine serum albumin (BSA), β-lapachone, N-phenyl-1-naphthylamine, d(−)-penicillamine, and mouse monoclonal (IgG) and anti-actin antibodies were obtained from the Sigma Chemical Co. (St. Louis MO). Yeast Hsp90 and radicicol were obtained from Alexis (San Diego, CA). Human Hsp90 was a kind gift from Dr. David Toft (Mayo Clinic College of Medicine, Rochester, MN). Recombinant human NQO1 (rhNQO1) was purified from Escherichia coli as described previously ( 19). The activity of rhNQO1 was 4.5 μmol DCPIP/min/mg protein. Malachite green phosphate assay kit was obtained from BioAssay Systems, Inc. (Hayward, CA). Mouse anti-Hsp70 and rabbit anti-Raf-1 antibodies were obtained from Stressgen (Vancouver, British Columbia, ...
Page contains details about 1,8-naphthalimide derivative/cucurbit[8]urils nanovesicles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The effect of the polycation polyethyleneimine (PEI) on the permeability properties of the Gram-negative bacterial outer membrane was investigated using Escherichia coli, Pseudomonas aeruginosa and Salmonella typhimurium as target organisms. At concentrations of less than 20 μg ml-1, PEI increased the bacterial uptake of 1-N-phenylnaphthylamine, which is a hydrophobic probe whose quantum yield is greatly increased in a lipid environment, indicating increased hydrophobic permeation of the outer membrane by PEI. The effect of PEI was comparable to that brought about by the well-known permeabilizer EDTA. Permeabilization by PEI was retarded but not completely inhibited by millimolar concentrations of MgCl2. PEI also increased the susceptibility of the test species to the hydrophobic antibiotics clindamycin, erythromycin, fucidin, novobiocin and rifampicin, without being directly bactericidal. PEI sensitized the bacteria to the lytic action of the detergent SDS in assays where the bacteria were pretreated
TY - JOUR. T1 - Excimer-monomer switch. T2 - A reaction-based approach for selective detection of fluoride. AU - Song, Qiao. AU - Bamesberger, Angela. AU - Yang, Lingyun. AU - Houtwed, Haley. AU - Cao, Haishi. PY - 2013/6/16. Y1 - 2013/6/16. N2 - A N-aryl-1,8-naphthalimide based sensor (ES-1) bearing a trimethylsilyl ether has been synthesized by a two-step reaction for quantitative detection of fluoride (F−). ES-1 exhibited monomer/excimer emissions at 410 and 524 nm respectively in CH2Cl2. In the presence of F−, the desilylation of trimethylsilyl ether caused decay of the excimer emission as well as enhancement of the monomer emission to give a ratiometric signal. The fluoride-triggered desilylation showed a high reaction rate and high affinity to F− over nine other interfering anions. ES-1 provided a novel fluorescence assay based on excimer-monomer switch of N-aryl-1,8-naphthalimide to quantitatively measure F− with a detection limit of 0.133 ppm.. AB - A N-aryl-1,8-naphthalimide ...
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A pilot study looking at the potential impact of e-cigarettes on the health of those who use them found a strong correlation between vaping and the presence of two carcinogens known to cause bladder cancer. The preliminary study analyzed the urine of 13 e-cigarette users and 10 non-user controls. The e-cigarette users had a median of 26 months of use. Researchers found two known carcinogens, otoluidine and 2-naphthylamine, in the samples of all but one of the e-cigarette users. Neither toxin was found in the nonuser samples. The study suggests that e-cigarettes are not without their own risks, despite being ... Read More. ...
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glycyl-aspartyl-aspartyl-aspartyl-aspartyl-lysine-2-naphthylamide: synthetic substrate linked via amide bond to fluorophore 2-naphthylamine
Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently, a considerable challenge. Intriguingly, mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans, have been a recent focus of research. Of these compounds, many are hydrophobic agents that associate with various sub-cellular organelles. Clearly, modification of such structures with mitochondria-targeting moieties, for example tagging them with lipophilic cations, would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. In this paper, we will review agents that possess anti-cancer activity by way of destabilizing mitochondria and their possible targets. We propose that mitochondrial targeting, in
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Naphthylamines, Anilines). ... 1-Naphthylamine is reacted with cyanogen bromide to give 2. ... 38 (1): 33-8. doi:10.1111/j.1365-2125.1994.tb04318.x. PMC 1364834. PMID 7946934. Schäbitz WR, Li F, Fisher M (July 2000). "The ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist". Journal of ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist". Journal of ...
Sudan Black is formed by coupling of diazotized 4-phenylazo-1-naphthylamine with 2,3-dihydro-2,2-dimethyl-1H-perimidine. ... Therefore, the main product expected was 2,3-dihydro-2,2dimethyl-6-[(4-phenylazo-1-naphthalenyl)-azo]-1H-perimidine. However ... HISTOCHEMISTRY AND CELL BIOLOGY Volume 16, Number 1 (1968), 68-84, DOI: 10.1007/BF00306212 Thin layer chrornatography and ... 1, SiO2) in thin Layer Chromatography). The above described product indeed turned out to be SSB-II which comprises up to 60% of ...
It is an intermediate in the production of naphthylamine, a precursor to dyes. Toxic. Booth, Gerald (2005). "Nitro Compounds, ... 1-Nitronaphthalene is an organic compound with the formula C10H7NO2. It is one of two isomers of nitronaphthalene. A pale ... yellow, sublimable solid, 1-nitronaphthalene is the main product of the direct nitration of naphthalene. ...
However, it is a weaker bidentate ligand as the nitrogen atom in the naphthylamine group is weakly coordinating due to the ... ethylenediamine undergoes most reactions typical to naphthylamine and primary amines such as diazotation. Similar to its analog ... N-(1-Naphthyl)ethylenediamine is an organic compound. It is commercially available as part of Griess reagents, which find ... This compound can be prepared by the reaction of 1-naphthylamine with 2-chloroethanamine. It is commercially available as the ...
Koe, BK (September 1983). "Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake ...
Sarges R, Koe BK, Weissman A, Schaefer JP (December 1974). "Blockade of heart 3H-norepinephrine up-take by 4-phenyl-1- ... Welch WM, Kraska AR, Sarges R, Koe BK (November 1984). "Nontricyclic antidepressant agents derived from cis- and trans-1-amino- ... Cyproheptadine [4-(5H-dibenz-[a,d]cyclohepten-5-ylidine)-1-methylpiperidine] Dasotraline Desmethylsertraline EXP-561 (1-amino-4 ... CP-51,974-1). Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the ...
51 (1): 273-282. doi:10.1002/cber.19180510132. Homer W. J. Cressman (1947). "N-Methyl-1-Naphthylcyanamide". Org. Synth. 27: 56 ... An example is the reaction of N,N-dimethyl-1-naphthylamine: These days, most chemist have replaced cyanogen bromide reagent ... 1984, 49, 11, 2081-2082 Publication Date:June 1, 1984 https://doi.org/10.1021/jo00185a072 March, Jerry (1985), Advanced Organic ...
1 Squadron) and CAC Sabres of No. 78 Wing carried out ground attack missions against the guerrillas. The Royal Australian Navy ... 1 Squadron (Avro Lincoln bombers) and No. 38 Squadron (C-47 transports), operating out of Singapore, early in the conflict. In ... 1): 53-74. Khoo, Agnes (2007). Life as the River Flows: Women in the Malayan Anti-Colonial Struggle. Monmouth, Wales: Merlin ... doi:10.1007/978-1-4899-0339-6. ISBN 9780306409738. S2CID 29278382. It was the British who were actually the first to use ...
2-Aminoindane 2-Aminotetralin 2-Naphthylamine Hathaway BA, Nichols DE, Nichols MB, Yim GK (May 1982). "A new, potent, ... 2-Amino-1,2-dihydronapthalene (2-ADN), also known as 2-aminodilin (2-AD), is a stimulant drug. It is a rigid analogue of ... It is closely related to 2-aminotetralin (2-amino-1,2,3,4-tetrahydronaphthalene), which also substitutes for amphetamine, and ... conformationally restricted analogue of amphetamine: 2-amino-1,2-dihydronaphthalene". Journal of Medicinal Chemistry. 25 (5): ...
... or 4-methylquinoline 1-Naphthylamine 2-Naphthylamine Quinaldine This set index page lists chemical structure articles ...
... it is suspected that metabolic hydrolysis of the amide group of FDU-NNE1 will release 1-naphthylamine, a known carcinogen. 5F- ...
For better differentiation, it is dipped in 1% acetic acid for 10-20 minutes or 30 sec until the colors are pure. This might ... 73 (1): 32-8. doi:10.1562/0031-8655(2001)073. 2.0.CO;2. PMID 11202363. S2CID 198157623. Kanitz, Andreas; Hartmann, Horst (1999 ... The Nile blue staining, according to Kleeberg, uses the following chemicals: Nile Blue A 1% acetic acid Glycerol or glycerol ... 2-nitrosophenols with 1-naphthylamine, 3-(dialkylamino)phenols with N-alkylated 4-nitroso-1-naphtylamines, or N,N-dialkyl-1,4- ...
243: 1-13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262. Gamage TF, Farquhar CE, Lefever TW, Marusich JA, Kevin RC, ... 33 (1): 165-169. doi:10.1007/s11419-014-0246-5. S2CID 13524298. v t e (Articles without EBI source, Chemical pages without ... It is suspected that metabolic hydrolysis of the amide group of NNE1 may release 1-naphthylamine, a known carcinogen, given the ... New Zealand Government Gazette, Notice Number 7051, 1 November 2012 Sasaki C, Saito T, Shinozuka T, Irie W, Murakami C, Maeda K ...
N-dimethyl-1-naphthylamine More than 400 other chemical compounds "Empirical formula search for C12H13N". ChemSpider. Retrieved ...
This diamine is used in place of the simpler and cheaper 1-naphthylamine because the latter is a potent carcinogen and moreover ... The most common arrangements use sulfanilamide and N-(1-naphthyl)ethylenediamine: a typical commercial Griess reagent contains ... 1-naphthyl)ethylenediamine in an azo coupling reaction, forming a pink-red azo dye. Using a spectrophotometer, it is possible ... 0.2% N-(1-naphthyl)ethylenediamine dihydrochloride, and 2% sulfanilamide in 5% phosphoric acid. ...
10 (1): 137-147. doi:10.1002/dta.2262. PMC 5785468. PMID 28834241. "Cannabinoider föreslås bli klassificerade som hälsofarlig ... it is suspected that metabolic hydrolysis of the amide group of MN-18 may release 1-naphthylamine, a known carcinogen. MN-18 ...
Condensation of Michler's ketone with N-phenyl-1-naphthylamine gives the dye Victoria Blue B (CAS#2580-56-5, CI Basic Blue 26 ... Charles D. DeBoer, Nicholas J. Turro, and George S. Hammond (1973). "cis- and trans-1,2-Divinylcyclobutane". Organic Syntheses ... absorbs intensely at 366 nm and effectively sensitizes photochemical reactions such as the dimerization of butadiene to give 1, ...
... it is suspected that metabolic hydrolysis of the amide group of 5F-PCN may release 1-naphthylamine, a known carcinogen. ...
5F-ADBICA 5F-SDB-006 AM-2201 FDU-NNE1 FUB-144 MMB-2201 NNE1 PX-1 "5F-NNEI". Southern Association of Forensic Scientists. ... it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen. ...
2-naphthylamine MeSH D04.615.638.870 - 1-naphthylisothiocyanate MeSH D04.615.638.900 - naphthylvinylpyridine MeSH D04.615. ... vitamin k 1 MeSH D04.615.638.721.374.844 - vitamin k 2 MeSH D04.615.638.721.374.922 - vitamin k 3 MeSH D04.615.638.845 - 1- ... naphthylamine MeSH D04.615.638.845.800 - sertraline MeSH D04.615.638.850 - ... 10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 - methylcholanthrene MeSH D04.615.149.700 - perylene MeSH D04.615.181.384 ...
Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 260 Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide ... Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V16 987 (1995) Cunningham, A. L., and J. V. Hurley. "Alpha‐ ... 1981., p. 1-2 NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases. U.S. Department of Health & Human Services, ... The usual method is the reaction of 1-naphthylamine hydrochloride with ammonium thiocyanate: [C10H7NH3]Cl + NH4SCN → C10H7NHC(S ...
... , a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of ... N,N-Bis(2-Chloroethyl)-2-Naphthylamine (Chlornaphazine), International Agency for Research on Cancer (ECHA InfoCard ID from ... Naphthylamines, Nitrogen mustards, Chloroethyl compounds, Withdrawn drugs, 2-Naphthyl compounds). ...
Naphthylamines). ... 1 April 2006. (CS1 errors: missing title, CS1: long volume ... The extinction coefficient for trypan blue is 6⋅104 M−1 cm−1 at 607 nm in methanol. Trypan red and trypan blue were first ...
... can refer to either of two isomeric chemical compounds: 1-Naphthylamine 2-Naphthylamine This set index page lists ...
... was previously used as a dye precursor and rubber antioxidant in the 1930s, 40s and 50s. Dupont stopped using ... 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. It is activated ... 2-Naphthylamine is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. Its acetyl ... 2-Naphthylamine is one of two isomeric aminonaphthalenes, compounds with the formula C10H7NH2. It is a colorless solid, but ...
... is an aromatic amine derived from naphthalene. It can cause bladder cancer (transitional cell carcinoma). It ... At 200 °C in sulfuric acid, it converts to 1-naphthol. The sulfonic acid derivatives of 1-naphthylamine are used for the ... Upon treatment with the bis(diazonium) derivative of benzidine, 1-aminonaphthalene-4-sulfonic acid gives Congo red. It is ... It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid followed by steam distillation. Oxidizing ...
... is used in the nitrate reductase test to form a red precipitate of Prontosil by reacting with a ... N,N-Dimethyl-1-naphthylamine is an aromatic amine. It is formally derived from 1-naphthylamine by replacing the hydrogen atoms ... "N,N-dimethylnaphthalen-1-amine". ChemSpider. Retrieved 15 April 2010. "D4011 N,N-Dimethyl-1-naphthylamine, ≥98.0% (GC)". Sigma- ... 1-Naphthyl compounds, Dimethylamino compounds, All stub articles, Amine stubs). ...
2-Naphthylamine Nickel compounds 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) N-Nitrosonornicotine (NNN) 2,3,4,7,8- ... 2-naphthylamine) Chlorambucil Bis(chloromethyl)ether Chloromethyl methyl ether Chromium(VI) (Hexavalent chromium) compounds ... Substances, mixtures, and exposure circumstances in this list have been classified as group 1 by the International Agency for ... "List of Classifications, Agents classified by the IARC Monographs, Volumes 1-124". IARC Monographs on the Evaluation of Risk to ...
Naphthylamines, Diamines). ... 1,5-Diaminonaphthalene is an organic compound with the formula ... It is prepared by reduction of 1,5-dinitronaphthalene, which in turn is obtained with the 1,8-isomers by nitration of 1- ... It can also be prepared by treatment of 1,5-dihydroxynaphthalene with ammonium sulfite. It is a precursor to naphthalene-1,5- ... Bernès, Sylvain; Pastrana, Modesto Rodríguez; Sánchez, Enrique Huerta; Pérez, René Gutiérrez (12 December 2003). "1,5- ...
He also proposed organic additions to rubber, such as toluidine and naphthylamine, in order to improve its properties. Those ... ISBN 978-1-931968-53-9. Rudolph D. Deanin (1987). History of Polymeric Composites. VSP. p. 327. ISBN 90-6764-082-4. ... He had patented more than 20 ways to produce butadiene (buta-1,3-diene), which were implemented industrially in the Soviet ...
... rosinduline from benzene-azo-α-naphthylamine and aniline and naphthinduline from benzene-azo-α-naphthylamine and naphthylamine ... Isorosinduline is obtained from quinone dichlorimide and phenyl-β-naphthylamine; ... The indulines may be subdivided into the following groups: (1) benzindulines, derivatives of phenazine; (2) isorosindulines; ...
Naphthylamines, Biphenyls, Organic sodium salts). ... Congo red is an organic compound, the sodium salt of 3,3′-([1,1 ... biphenyl]-4,4′-diyl)bis(4-aminonaphthalene-1-sulfonic acid). It is an azo dye. Congo red is water-soluble, yielding a red ...
... regarding exposure to textile dyes and occupational bladder cancer due to aniline dye intermediates such as beta-naphthylamine ... 35 (1-2): 45-51. PMID 18516877. Metgud, D C; Khatri, S; Mokashi, M G; Saha, P N (2008). "An ergonomic study of women workers in ... Nur, Shah Alam (1 May 2013). "Space shortages at rented houses make RMG units non-compliant". The Financial Express. Bangladesh ... 1] "Garment Workers in Bangladesh." Archived 5 June 2011 at the Wayback Machine [2] Naila Kabeer and Simeen Mahmud. "Rags, ...
... naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects ... "1-(2,3-Dihydro-1H-inden-5-yl)-2-(ethylamino)pentan-1-one". pubchem.ncbi.nlm.nih.gov. Gaspar H, Bronze S, Ciríaco S, Queirós CR ... "1-(2,3-Dihydro-1H-inden-5-yl)-2-pyrrolidin-1-ylbutan-1-one". pubchem.ncbi.nlm.nih.gov. "α-PBT". Cayman Chemical. Retrieved 27 ... 12 (1): 136-144. doi:10.1002/dta.2698. PMID 31788963. Nakajima JI, Takahashi M, Uemura N, Seto T, Fukaya H, Suzuki J, et al. ( ...
Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N- ... acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, ... 54 (1): 190-192. doi:10.1016/0006-3002(61)90954-4. PMID 14005907. Portal: Biology v t e (EC 2.3.1, Enzymes of known structure, ... 204 (1): 127-138. PMID 13084583. Weissbach H, Redfield BG, Axelrod J (1961). "The enzymic acetylation of serotonin and other ...
... notably including fabric dyes such as indigo and naphthylamine. It was discovered that the long standing deterioration of the ... 46 (1): 48-81. doi:10.1016/0026-265X(92)90023-V. ISSN 0026-265X. "Italy's environmental disaster equals an HIV epidemic , IRPI ... 1 (2): 279-314. doi:10.1093/es/1.2.279. ISSN 1467-2227. JSTOR 23699775. Capanna, Saverio (2015). "L'ACNA di Cengio nel contesto ...
Anilines and naphthylamines form more stable diazonium salts, which can be isolated in the crystalline form. Diazonium salts ... Retrieved 1 March 2022. Howarth, Graham (1 January 1995). "The use of water‐based epoxies for anti‐corrosive primers". Pigment ... H − N , R 2 R 1 , : ⏟ amine + R 3 − C O ‖ − OH ⏟ carboxylic acid − > H − N + , R 2 R 1 , − H + R 3 − COO − ⏟ substituted- ... ISBN 1-57259-153-6. Dill, Ken A. (1990). "Dominant forces in protein folding". Biochemistry. 29 (31): 7133-55. doi:10.1021/ ...
... including benzidine and β-Naphthylamine. Hueper warned them explicitly of dangers to their workers in 1937, and throughout 1938 ... Health, 1 (1995) pp. 278-288. Ibid., Agran, at p. 175 Devra Davis, The Secret History of Cancer (Basic Books, 2007) Ch. 4, page ... 1, 1966) Environmental Cancer, by W.C. Hueper (1974) Larry Agran, The Cancer Connection (NY, St. Martin's 1977), p. 173 Devra ... 1, No. 3 (1995), pp. 278-288. Asbestos: Medical and Legal Aspects, Fifth Edition, by Barry I. Castleman (Mar. 2005) Devra Davis ...
The Bucherer reaction in organic chemistry is the reversible conversion of a naphthol to a naphthylamine in the presence of ... The enamine eliminates sodium bisulfite with formation of naphthylamine 6. It is important to stress that this is a reversible ... in German). 69 (1): 49-91. doi:10.1002/prac.19040690105. Seeboth, Habil H. (1967). "The Bucherer Reaction and the Preparative ... 1. pp. 63-90. doi:10.1002/0471264180.or001.05. ISBN 9780471264187. Pötsch, Winfried R.; Fischer, Annelore; Müller, Wolfgang ( ...
Victoria blues are members of the triarylmethane dyes, but unlike most such dyes, the Victoria blues have a naphthylamine group ... Victoria Blue BO base, also known as Solvent Blue 5 and C.I. 42595:1, is the hydroxide derivative of the same cation. Its ...
2-naphthylamine, benzidine, 4-aminodiphenyl, 4-nitrodiphenyl, their salts and any substance containing any of those compounds ... Use of the following substances is prohibited for the purposes specified (reg.4(1)/ Sch.2): The following are excluded from the ... Act 1974, ss.33(1)(c), 33(3) "SI 2015/664". Interpretation Act 1978, s.5 "(K) Miscellaneous offences - Health and Safety ... 1): Council Directive 90/394/EEC, on the protection of workers from risks related to exposure to carcinogens at work, insofar ...
The amidine formed with 2-naphthylamine and the dimethyl sulfate adduct can be cyclized with sodium methoxide to give benzo[f] ... The vinamidinium salt 1,1,5,5-tetramethyl-1,5-diazapentadienium chloride reacts with heterocycles bearing CH-acidic groups to ... The same vinamidinium salt 1,1,5,5-tetramethyl-1,5-diazapentadienium chloride is also formed in the reaction of 3- ... 3-Dimethylaminoacroleincan be reacted with CH-acidic compounds (such as malononitrile) to 1,3-butadiene derivatives or with ...
Naphthylamines, Naphthalenesulfonic acids, All stub articles, Aromatic compound stubs). ... 4-Amino-1-naphthalenesulfonic acid; MSDS No. 250619; Sigma-Aldrich Chemie GmbH: Steinheim, 29 Dec 2011. Gerald Booth " ... It is prepared by treating 1-aminonaphthalene with sulfuric acid. ...
Nature 201:622-623 Muftic MK (1964). N-acetyl-naphthylamine esterase activity as a virulence test in Mycobacteria. Zentralbl ... 30;18(1):14-7 Muftic MK (1958). A psychokinetic theory of hypnotism. Br. J. Med. Hypn. 10: 11-23. Muftic MK (1958). Mycostatin ... Mycoses Volume 1, Issue 5, pp. 156-161. Muftic MK (1958). Prevention of Hemorrhages in E. N. T. Surgery by Interstitial ... 50(1):3-12. Muftic MK (1960). Genus Blastomycoides As A Mykological Entity. Mycoses Volume 3, Issue 1, pp. 16-25 Muftic MK ( ...
Naphthylamines, Tertiary amines). ... 1838 (1 Pt B): 173-84. doi:10.1016/j.bbamem.2013.09.009. PMID ... 1565 (1): 123-8. doi:10.1016/s0005-2736(02)00514-x. PMID 12225860. Brignac-Huber, L.M; Reed, JR.; Eyer, MK.; Backes, WL. (2013 ... 1841 (1): 1-10. doi:10.1016/j.bbalip.2013.08.015. PMID 24012824. Laboratory of Membrane Trafficking, Signaling and ... 75 (1): 419-421. Bibcode:1998BpJ....75..419J. doi:10.1016/s0006-3495(98)77528-9. PMC 1299713. PMID 9649401. Demchenko, ...
The risk from aromatic amines, particularly benzidine and a-and ß-naphthylamine, was not well-established until the 1950s. In ... 20 (1): 32-34. doi:10.1258/jmb.2011.011002. PMID 22499606. S2CID 25828962. Archived from the original (PDF) on 2018-12-05. ( ...
1998)‎. N-phenyl-1-naphthylamine. World Health Organization. https://apps.who.int/iris/handle/10665/42078 ...
alpha-Naphthylamine (DOT:OSHA). C.I. Azoic Diazo Component 114. Fast Garnet B Base. Fast Garnet Base B. Naphthalidam. ... National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-NAPHTHYLAMINE-air. Carcinogen ... 1-Naftilamina (Spanish). 1-Naftylamin (Czech). 1-Naftylamine (Dutch). 1-Naphthylamin (German). Alfanaftilamina (Italian). alfa- ... TRK-TMW 0.17 ppm (1 mg/m3);KZW 0.68 ppm (4 mg/m3), inhal, skin, 2007. ...
1-Naphthylamine is an aromatic amine derived from naphthalene. It can cause bladder cancer (transitional cell carcinoma). It ... At 200 °C in sulfuric acid, it converts to 1-naphthol. The sulfonic acid derivatives of 1-naphthylamine are used for the ... Upon treatment with the bis(diazonium) derivative of benzidine, 1-aminonaphthalene-4-sulfonic acid gives Congo red. It is ... It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid followed by steam distillation. Oxidizing ...
1998)‎. N-phenyl-1-naphthylamine. World Health Organization. https://extranet.who.int/iris/restricted/handle/10665/42078 ...
... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof from Germany were Bosnia and ... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof. Please note: Exports is gross ... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof. 2021. Germany. 7.24. 38. Kg. ... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof. 2021. Germany. 2.85. 68. Kg. ...
N-phenyl-1-naphthylamine. Contributor(s): Koennecker, G , Mangelsdorf, Inge , Wibbertmann, A , World Health Organization , ... 1-Naphthylamine -- toxicity -- adverse effects , Environmental exposure , Dose-response relationship, Drug , Chemical ...
... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof from India ($0.06K , 0 Kg)Sri ... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof was $0.06K and quantity 0Kg.. ... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof was $0.06K and quantity 0Kg.. ... alpha-naphthylamine), 2-naphthylamine (beta-naphthaylamine) and their derivatives; salts thereof from India ($0.06K , 0 Kg).. ...
Polyclonal Custom Antibodies Package 1 (Protein to Antisera). Rated 0 out of 5 ...
1-naphthylamine , 134-32-7 C10H9N structure,synthetic routes, physical and chemical properties, safety information, toxicity, ... customs data,maps, MSDS, generation methods and uses, and 1-naphthylaminesupstream and downstream products. ... alpha-Naphthylamine. Proper shipping name:. Packing group: III Y. Marine pollutant. Section 15. REGULATORY INFORMATION. Safe ... Compound Synonyms: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 1 2 3 4 5 6 7 8 9 ...
1,2,3,4-tetrahydro-1-naphthylamine. Regulatory process names 2 CAS names 1 IUPAC names 5 Other identifiers 2 ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ...
S H Preskorn 1 , J Alderman, M Chung, W Harrison, M Messig, S Harris ... Desipramine trough concentrations approached baseline within 1 week of sertraline discontinuation but remained elevated for the ...
This page contains information on the chemical 1-Naphthaleneacetamide including: 28 synonyms/identifiers. ... 1-Naphthaleneacetamide. Identifications. *CAS Number: 86-86-2*Caswell Number: 588*Synonyms/Related:*.alpha.- ... Amid kyseliny 1-naftyloctove [Czech]*Amid-Thin*Amid-Thin W*Dirigol N*Frufix*Fruitone*NAAm*Naamide*NAD*Naphthalene acetamide* ... 1-Naphthylacetamide*1-Naphthylamine, N-acetyl-*2-(1-Naphthyl) acetamide*2-(1-Naphthyl) acetamide [BSI:ISO]*alpha-NAA amide* ...
1 Department of Clinical Pharmacy, University of Texas Health Science Center at San Antonio 78284-6220, USA. ...
Evaluation of the potential carcinogenicity of 2-naphthylamine (91-59-8) /. 1988. ... Showing: Items 1 - 31. Your Search: (SUBJECT=Naphthalenes) Sort Results: Publication dates (newest-oldest). Publication dates ( ... Draft toxicological profile for naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene /. 2003. 7. Environmental monitoring ... Toxicological profile for naphthalene, 1-methylnaphthalene, and 2-methylnaphthalene /. 2005. 31. Toxicological review of ...
1,2,3-propanetriyl tris[(R)-12-(acetoxy)oleate] 202-935-1 101-34-8 Active Full Joint ≥ 1 to , 10 tonnes 28-05-2021 View ... 1,2,2,6,6-pentamethylpiperidin-4-ol 219-292-8 2403-89-6 Active Full Joint ≥ 100 to , 1 000 tonnes 03-03-2022 View substance ... 1,2,3,6-tetrahydro-3-methylphthalic anhydride 226-247-6 5333-84-6 Active Full Joint ≥ 1 000 to , 10 000 tonnes 02-07-2020 View ... 1,2,3,5-tetraacetyl-beta-D-ribofuranose 235-898-5 13035-61-5 Active Intermediate Joint Intermediate use only 18-12-2018 View ...
4-tetrahydro-2-naphthylamine could not be prepared by this method. ...
1.Identification. 1.1 GHS Product identifier Product name. Ethynyltrimethylsilane. 1.2 Other means of identification Product ... 1 1. Ality Chemical Corporation. Contact Supplier Trimethylsilylacetylene. Cas No: 1066-54-2. No Data. 10 Milligram. Amadis ... 1 Metric Ton/Day. Henan Tianfu Chemical Co., Ltd.. Contact Supplier Top Purity CAS 1066-54-2 with fast shipping. Cas No: 1066- ... High quality Antioxidant PAN (A) CAS:1066-54-2 N-Phenyl-1-naphthylamine. Cas No: 1066-54-2. USD $ 2.0-5.0 / Kilogram. 1 ...
Y1 - 1996/10/1. N2 - In this report, we describe a strategy for enhancing the immunogenicity of a wide variety of Ags by ... In Vivo Properties of an IgG3-IL-2 Fusion Protein: A General Strategy for Immune Potentiation 1. Journal of Immunology. 1996 ... In Vivo Properties of an IgG3-IL-2 Fusion Protein : A General Strategy for Immune Potentiation 1. / Harvill, Eric T.; Fleming, ... title = "In Vivo Properties of an IgG3-IL-2 Fusion Protein: A General Strategy for Immune Potentiation 1", ...
... naphthyl)amine. To the best of our knowledge this is the very first example of a direct 3‐fold cyclization of a triarylamine ... These stimulatory effects were inhibited by dorsomorphin 1, a small‐molecule inhibitor of the BMP‐type I receptors activin ... The compound is accessible through an intramolecular oxidative cyclodehydrogenation of tri(1‐ ... 1. The presence of an α,β‐unsaturated lactone ring at C‐17, a β‐hydroxy group at C‐14 and C‐3β‐OR substituents were considered ...
2-naphthylamine and benzidine) in the muscle tissue of fish. There were marked seasonal variations in the aromatic amine levels ... was free from 2-naphthylamine and benzidine in winter and autumn. The variation may be related to the feeding habits or the ... 2-naphthylamine and benzidine in the muscle tissue of 4 types of fish: Tilapia sp. and Claris sp. from Lake Edku and Mugil sp. ... 2-naphthylamine and benzidine) in the muscle tissue of fish. There were marked seasonal variations in the aromatic amine levels ...
Présentement, ses principaux axes de recherche comprennent : Axe 1 : Métabolisme des hydrocarbures aromatiques polycycliques ... Présentement, ses principaux axes de recherche comprennent : Axe 1 : Métabolisme des hydrocarbures aromatiques polycycliques ... Toxicol., 100 (1): 8-13.. DOI: 10.1007/s00128-017-2239-7. Alsaadi, Ftoon; Madison, Barry N.; Brown, R. S.; Hodson, P. V. & ... Axis 1: Metabolism of polycyclic aromatic hydrocarbons in aquatic species. *Axis 2: Emerging pollutants and their impact on the ...
These include aniline dyes (eg, 2-naphthylamine, 4-aminobiphenyl, 4-nitrobiphenyl, 4-4-diaminobiphenyl [benzidine], 2-amino-1- ... Table 1. Proportion of Patients With Bladder Cancer Treated With Partial Cystectomy (Open Table in a new window) ... Solitary, high grade muscle-invasive tumor located in a position that is amenable to wide resection (ideally achieving 1-2 cm ... Pheochromocytoma of the bladder is a rare neoplasm, accounting for less than 1% of all bladder tumors. Pheochromocytoma is a ...
1-11.. Ochoa Bique, A., Maia, L.K.K., La Mantia, F., Manca, D., Zondervan, E. (2019) Balancing costs, safety and CO2 emissions ... 76, 1-11.. Tulpule, K., Hohnholt, M.C., Hirrlinger, J., Dringen, R. (2014): Primary cultures of astrocytes and neurons as model ... Degrad.1(1), 6.. Breckling, B., von Gleich, A. (2020): Gene Drives Touching Tipping Points. In Gene Drives at Tipping Points ( ... Ecology and Evolution 1-13 DOI: 10.1002/ece3.3830. Quinson, J.; Inaba, M.; Neumann, S.; Swane, A. A.; Bucher, J.; Simonsen, S. ...
Exploration of the adsorption performance and mechanism of zeolitic imidazolate [email protected] oxide for Pb(II) and 1- ... naphthylamine from aqueous solution. Wang JY, Li YC, Lv ZM, Xie Y, Shu JJ, Alsaedi A, Hayat T, Chen CL. Journal of Colloid and ...
2-NAPHTHYLAMINE. 1-(PHENYLAZO)-2-NAPHTHYLAMINE. Unique Ingredient Identifier (UNII). Drug Active Ingredients. Details. ... 1,1,2,2-TETRAFLUOROETHANE. 1,1,2,2-TETRAFLUOROETHANE. Unique Ingredient Identifier (UNII). Drug Active Ingredients. Details. ... 1,1,1-TRICHLOROETHANE. 1,1,1-TRICHLOROETHANE. Unique Ingredient Identifier (UNII). Drug Active Ingredients. Details. ... 1,2,6-HEXANETRIOL. 1,2,6-HEXANETRIOL. Unique Ingredient Identifier (UNII). Drug Active Ingredients. Details. ...
Known: benzene (leukaemia); vinyl chloride (liver angio-sarcoma); 2-naphthylamine, benzidine (bladder cancer); asbestos (lung ... In this section and in table 1 a brief description of the various hazards will be given together with examples of environments ... The hazards might be of chemical, biological or physical origin (see table 1). Some hazards in the work environment are easy to ... Concentrations for 20 substances were listed under the headings: (1) rapidly fatal to man and animals, (2) dangerous in 0.5 to ...
InChI=1S/C10H9NO3S/c11-9-5-6-10(15(12,13)14)8-4-2-1-3-7(8)9/h1-6H,11H2,(H,12,13,14). ...
  • A bulk powder sample of an additive contained approximately 1 part per million of alpha-naphthylamine (134327). (cdc.gov)
  • Offering you a complete choice of products which include n phenyl alpha naphthylamine, pan dye intermediates and phenyl alpha naphthylamine. (acetochemindia.in)
  • Manufacturer of a wide range of products which include alpha naphthylamine. (acetochemindia.in)
  • Manufacturer of 1-Naphthol-5-Sulphonic Acid (L Acid), 1-Phenyl Alpha Naphthylamine, 1,5-Dihydroxy Naphthalene, 2-Amino-6-Chloro-4-Nitro Propargyl Chloride. (needsinfo.com)
  • 1993. Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine. (cdc.gov)
  • https://www.cancer.org/cancer/bladder-cancer/causes-risks-prevention/risk-factors.html Other causes of bladder cancer are exposure to chemical pollutants such as benzidine and beta-naphthylamine, which are sometimes used in the dye industry. (ontarionaturopathicclinic.ca)
  • The sulfonic acid derivatives of 1-naphthylamine are used for the preparation of azo dye. (wikipedia.org)
  • The present invention more particularly relates to a culture medium for the detection of at least one target microorganism including: at least one natural or synthetic fermentation or enzymatic activity substrate, and at least one selective agent, which inhibits non-target microorganisms, constituted by para-amino benzoic acid, one of its derivatives or one of their salts, at a concentration of between 0.05 and 1 g/L. (justia.com)
  • Lubricating oils of enhanced oxidation stability are obtained by adding to the lubricating oil a mixture comprising carbodiimide as acid scavenger and either n-phenyl-1-naphthyl amine or its substituted derivatives as amine anti-oxidant. (epo.org)
  • It is also used in dye manufacture to inhibit oxidation of sensitive amine groups, to replace chlorine groups with the sulfite radical and as an aid in the formation of naphthylamine derivatives. (affygility.com)
  • Upon treatment with the bis(diazonium) derivative of benzidine, 1-aminonaphthalene-4-sulfonic acid gives Congo red. (wikipedia.org)
  • الخلاصـة: قاس الباحثون في بحيرة إدكو والبحر المتوسط، في منطقة المعدية، ثلاثة مركبات أمينية أروماتية هي (1-naphthylamine 2-naphthylamine, benzidine) في أنسجة عضلات السمك. (who.int)
  • We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines (1-naphthylamine, 2-naphthylamine and benzidine) in the muscle tissue of fish. (who.int)
  • Nous avons réalisé une estimation de la pollution dans le lac Edkou et en Méditerranée (région d'El-Maadiya), sur la base de trois amines aromatiques (1-naphthylamine, 2-naphthylamine et benzidine) dans les tissus musculaires de poissons. (who.int)
  • It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid followed by steam distillation. (wikipedia.org)
  • Chromic acid converts it into 1-naphthoquinone. (wikipedia.org)
  • At 200 °C in sulfuric acid, it converts to 1-naphthol. (wikipedia.org)
  • An important derivative is naphthionic acid (1-aminonaphthalene-4-sulfonic acid), which is produced by heating 1-naphthylamine and sulfuric acid to 170-180 °C in the presence of crystallized oxalic acid. (wikipedia.org)
  • In the second part, quantum chemical calculations were performed on aniline and 1-naphthylamine interacting with acetic acid, acetamide, imidazole, and phenol as models of functional groups present in humic substances. (ttu.edu)
  • 1-(5-Fluoro-pentyl)-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid naphthalen-1-ylamide and all other designer drugs sold on this website are intended for research and forensic applications. (sejie4.us)
  • Further, the ability to reduce nitrate to nitrite can be detected with the addition of sulphanilic acid and a-naphthylamine, which results in a red precipitate (prontosil). (sigmaaldrich.com)
  • ready to use with haemoglobin standard, in a pack size of 1 litre , hematoxylin ( bdh ) , in a pack size of 25gm , hexamethylene hetramine ( metheneamine ) , in a pack size of 250gm , hexamine 500gm , hydrochloric acid ( conc. (haryanatenders.net)
  • 1. A compound formed by the interaction of an acid and a base , the ionizable hydrogen atoms of the acid being replaced by the positive ion of the base . (en-academic.com)
  • 1. Introduction amines and vinyl chloride) ( Gochfeld, 2005a,b ). (cdc.gov)
  • 1-Naphthylamine is an aromatic amine derived from naphthalene. (wikipedia.org)
  • Tobacco smoke contains nicotine, carbon monoxide (4%), nitric oxide, and numerous aromatic hydrocarbons and other substances known to be carcinogens, including benzo[ a ]pyrene, β-naphthylamine, and nitrosamines. (thefreedictionary.com)
  • First, analytical solutions of kinetic models were fitted to experimental data of batch sorption experiments with aniline and 1-naphthylamine onto animal manure-treated soil and the soil mineral montmorillonite. (ttu.edu)
  • Molecular modeling showed that formation of hydrogen bonds is the dominating binding mechanism in all modeled complexes, which are energetically very similar between aniline and 1-naphthylamine. (ttu.edu)
  • Desipramine trough concentrations approached baseline within 1 week of sertraline discontinuation but remained elevated for the 3-week follow-up period after fluoxetine discontinuation. (nih.gov)
  • At the lower ebook stammkunden management in Figure 3 gives the OP, where each electron is upstream and employs the adaptive carbon stability from where part states suited from six 1 substance water Compounds. (dannhorn-mak.net)
  • Our product range includes a wide range of n phenyl-1-naphthylamine, phenyl-1-naphthylamine pure, c16h13n dye intermediates and dye intermediates. (acetochemindia.in)
  • Similarly, 1-naphthylamine displays carcinogenic exercise only in check systems capable of producing the N-hydroxy metabolite of naphthylamine. (edu.pl)
  • Manufacturing Pharma Raw Materials, 1,2-Di Methoxy Ethane (Monoglyme) 1,4-Dioxane 2,4-Dichlorobenzyl chloride 2-Methyl Dimethylaniline. (needsinfo.com)
  • Previous assignment of the olefinic proton signals (H-1 and H-2) in the 1 H-nmr spectra of dienoid-type erythrinan alkaloids was interchanged on the basis of the synthesis of the stereoisomers, nOe experiments, and theoretical calculations. (heterocycles.jp)
  • 1998)‎. N-phenyl-1-naphthylamine. (who.int)
  • Manufacturer of 3,3-Diamino-Sulfonyl bis benzene (Cas No. 599-61-1), 2-Amino Sulfonyl bis benzene Dimethylaniline. (needsinfo.com)
  • Title : NIOSH current intelligence bulletin : reprints - bulletins 1 thru 18 (1975-1977) Corporate Authors(s) : National Institute for Occupational Safety and Health. (cdc.gov)
  • naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. (cdc.gov)
  • 1-Ethylimidazole Name:1-Ethylimidazole Synonym:N-ETHYLIMIDAZOLE;1-ETHYLIMIDAZOLE;1-ETHYL-1H-IMIDAZOLE;1H-Imidazole, 1-ethyl-;Imidazole, 1-ethyl-;Oxalethylin CAS: 7098-07-9 EINECS:230-403-9 Assay:99% M. (lulusoso.com)
  • 1-Chloromethyl naphthalene Name:1-Chloromethyl naphthalene Synonym:1-(Chlormethyl)naftalen;1-(chloromethyl)-naphthalen;1-(Chloromethyl)naphthene;1-chloromethyl-naphthalen;1-Menaphthyl chloride;1-menap. (lulusoso.com)
  • Partial cystectomy is indicated in the patient with a normally functioning bladder with good capacity and a solitary tumor located where a 1-cm to 2-cm resection margin is possible. (medscape.com)
  • Its primary malignant indication is for solitary, primary, muscle-invasive, or high-grade bladder cancer that does not involve specific regions of the bladder such as the bladder trigone, vesical neck, or posterior urethra and that can be resected with adequate surgical margins (1-2 cm). (medscape.com)
  • the maximum decrease order tapentadol 100mg online india in blood pressure occurred between 1 and 4 hours after dosing. (avclark.com)
  • 4) 10 Because possible pleasure access is the size of volumes in the 2-3'-naphthylamine ilour of the laden y, the mmol of the E O F is relative on the O157 present h.( depletion) 2 6. (doochin.com)
  • N,N-dimethyl-1-aminonaphthalene-5-sulfonyl chloride). (elsevier.com)
  • Exporter of 1-Acetoxy-2-butoxyethane (Cas No: 112-07-2), 1-Acetyl-4-(4-Hydroxyphenyl)Piperazine (Cas No 67914-60-7), 1-Acetylnaphthalene (Cas Propargyl Chloride. (needsinfo.com)
  • Chloroformates : Benzyl Chloroformate (50% In Toluene [501-53-1], Vinyl Chloroformate [5130-24-5], Isocyanates Propargyl Chloride. (needsinfo.com)
  • 1 a) a crystalline compound NaCl that is the chloride of sodium, is abundant in nature, and is used esp. (en-academic.com)
  • Inhibitors of programmed cell death 1 (PD-1) protein and its ligands PD-L1 and PD-L2, are first-line agents in patients with metastatic urothelial carcinoma who are not candidates for cisplatin chemotherapy, and second-line agents for those with disease progression despite cisplatin-based chemotherapy. (medscape.com)