1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.2-Naphthylamine: A naphthalene derivative with carcinogenic action.Naphthalenes: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.DiethylaminesDimethylaminesChemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hydroxylamines: Organic compounds that contain the (-NH2OH) radical.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Aminobiphenyl Compounds: Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.Benzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Sulfonic Acids: Inorganic or organic oxy acids of sulfur which contain the RSO2(OH) radical.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Chromatography, Paper: An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Caustics: Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year.Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)Isocyanates: Organic compounds that contain the -NCO radical.Nitric Acid: Nitric acid (HNO3). A colorless liquid that is used in the manufacture of inorganic and organic nitrates and nitro compounds for fertilizers, dye intermediates, explosives, and many different organic chemicals. Continued exposure to vapor may cause chronic bronchitis; chemical pneumonitis may occur. (From Merck Index, 11th ed)Cyanates: Organic salts of cyanic acid containing the -OCN radical.Aminoacyltransferases: Enzymes that catalyze the transfer of an aminoacyl group from donor to acceptor resulting in the formation of an ester or amide linkage. EC 2.3.2.Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.Fluorometry: An analytical method for detecting and measuring FLUORESCENCE in compounds or targets such as cells, proteins, or nucleotides, or targets previously labeled with FLUORESCENCE AGENTS.Cadaverine: A foul-smelling diamine formed by bacterial decarboxylation of lysine.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Carica: A plant genus of the family Caricaceae, order Violales, subclass Dilleniidae, class Magnoliopsida. It is the source of edible fruit and PAPAIN.Adenylate Cyclase: An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Phenoxypropanolamines: Compounds based on a propanolamine attached via an OXYGEN atom to a phenoxy ring. The side chain is one carbon longer than PHENYLETHYLAMINES.Lubrication: The application of LUBRICANTS to diminish FRICTION between two surfaces.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Aniline CompoundsAniline Hydroxylase: A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Purpura, Schoenlein-Henoch: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antigens: Substances that are recognized by the immune system and induce an immune reaction.Buffers: A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Hematinics: Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.

Helicobacter pylori uptake and efflux: basis for intrinsic susceptibility to antibiotics in vitro. (1/96)

We previously demonstrated (M. M. Exner, P. Doig, T. J. Trust, and R. E. W. Hancock, Infect. Immun. 63:1567-1572, 1995) that Helicobacter pylori has at least one nonspecific porin, HopE, which has a low abundance in the outer membrane but forms large channels. H. pylori is relatively susceptible to most antimicrobial agents but less susceptible to the polycationic antibiotic polymyxin B. We demonstrate here that H. pylori is able to take up higher basal levels of the hydrophobic fluorescent probe 1-N-phenylnaphthylamine (NPN) than Pseudomonas aeruginosa or Escherichia coli, consistent with its enhanced susceptibility to hydrophobic agents. Addition of polymyxin B led to a further increase in NPN uptake, indicative of a self-promoted uptake pathway, but it required a much higher amount of polymyxin B to yield a 50% increase in NPN uptake in H. pylori (6 to 8 microg/ml) than in P. aeruginosa or E. coli (0.3 to 0.5 microg/ml), suggesting that H. pylori has a less efficient self-promoted uptake pathway. Since intrinsic resistance involves the collaboration of restricted outer membrane permeability and secondary defense mechanisms, such as periplasmic beta-lactamase (which H. pylori lacks) or efflux, we examined the possible role of efflux in antibiotic susceptibility. We had previously identified in H. pylori 11637 the presence of portions of three genes with homology to potential restriction-nodulation-division (RND) efflux systems. It was confirmed that H. pylori contained only these three putative RND efflux systems, named here hefABC, hefDEF, and hefGHI, and that the hefGHI system was expressed only in vivo while the two other RND systems were expressed both in vivo and in vitro. In uptake studies, there was no observable energy-dependent tetracycline, chloramphenicol, or NPN efflux activity in H. pylori. Independent mutagenesis of the three putative RND efflux operons in the chromosome of H. pylori had no effect on the in vitro susceptibility of H. pylori to 19 antibiotics. These results, in contrast to what is observed in E. coli, P. aeruginosa, and other clinically important gram-negative bacteria, suggest that active efflux does not play a role in the intrinsic resistance of H. pylori to antibiotics.  (+info)

Effect of polymorphisms on ligand binding by mouse major urinary proteins. (2/96)

Mouse urine contains an abundance of major urinary proteins, lipocalins, whose roles include slow release of semiochemicals. These proteins are highly polymorphic, with small sequence differences between individual members. In this study, we purified to homogeneity four of these proteins from two strains of inbred mice and characterized them by mass spectrometry. This analysis has led to the discovery of another variant in this group of proteins. Three of the polymorphic variants that map to the surface have no effect on the binding of a fluorescent probe in the binding cavity, but the fourth, characterized by a Phe to Val substitution in the cavity, shows a substantially lower affinity and fluorescence yield for the probe. These results are interpreted in light of the known crystal structure of the protein and molecular modeling calculations, which rationalize the experimental findings. This work raises the possibility that the calyx-binding site can show specificity for different ligands, the implications of which on pheromone binding and chemical communication are discussed.  (+info)

The micronucleus assay in human exfoliated urothelial cells: application in a genotoxicity study of workers exposed to a mineral jelly containing sodium nitrite and N-phenyl-1-naphthylamine. (3/96)

Exposure to certain chemical agents in occupational settings has been identified as carcinogenic to the human bladder. Micronucleus (MN) analysis in exfoliated urothelial cells is an interesting method for biomonitoring genetic damage in human populations. However, few studies have been performed in an occupational context. The aim of this study was to examine whether the occupational use of a mineral jelly induced a genotoxic risk for workers employed at a single factory producing bearings using the MN test on exfoliated urothelial cells. The prevalence of micronucleated exfoliated urothelial cells (MNC) was determined in 35 female workers with dermal exposure to the jelly and 41 female controls. The mean percentage of MNC (expressed as percent cells with MN per 1000 cells scored) observed in the exposed worker group was 0.46 +/- 0.11% (range 0-2.8) and in the control group 0.14 +/- 0.03% (range 0-0.8). There is a significant job effect (P = 0.0018, MANCOVA) on the prevalence of MNC, whereas age and smoking habit had no significant effect (P = 0.90 and 0.91, respectively). There is no interaction between job and smoking habit (P = 0.4421). Exposure to the mineral jelly appeared to be the main factor inducing the increased prevalence of MNC. This may be due to the presence of mutagens/carcinogens in the jelly: an aromatic amine, N-phenyl-1-naphthylamine (CAS no. 90-30-2), which is carcinogenic in mice, or sodium nitrite (CAS no. 7632-00-0), which is genotoxic in human cell systems. In conclusion, these results suggest that use of the mineral jelly could present a genotoxic risk for workers. We think that the MN assay on exfoliated cells could be valuable for biological monitoring purposes in occupational contexts as a marker of significant exposure to bladder mutagenic/carcinogenic agents.  (+info)

Specific interactions of the antimicrobial peptide cyclic beta-sheet tachyplesin I with lipopolysaccharides. (4/96)

The cyclic beta-sheet antimicrobial peptide tachyplesin I (T-SS) was found to show 280-fold higher affinity for lipopolysaccharides (LPS) compared with acidic phospholipids, whereas the linear alpha-helical peptide F5W-magainin 2 (MG2) could not discriminate between LPS and acidic phospholipids. The recognition site was the lipid A moiety and the cyclic structure was crucial to this specific binding. The cyclic structure also endowed the peptide with very rapid outer membrane (OM) permeabilization.  (+info)

Rhamnolipid stimulates uptake of hydrophobic compounds by Pseudomonas aeruginosa. (5/96)

The biodegradation of hexadecane by five biosurfactant-producing bacterial strains (Pseudomonas aeruginosa UG2, Acinetobacter calcoaceticus RAG1, Rhodococcus erythropolis DSM 43066, R. erythropolis ATCC 19558, and strain BCG112) was determined in the presence and absence of exogenously added biosurfactants. The degradation of hexadecane by P. aeruginosa was stimulated only by the rhamnolipid biosurfactant produced by the same organism. This rhamnolipid did not stimulate the biodegradation of hexadecane by the four other strains to the same extent, nor was degradation of hexadecane by these strains stimulated by addition of their own biosurfactants. This suggests that P. aeruginosa has a mode of hexadecane uptake different from those of the other organisms. Rhamnolipid also enhanced the rate of epoxidation of the aliphatic hydrocarbon alpha,omega-tetradecadiene by a cell suspension of P. aeruginosa. Furthermore, the uptake of the hydrophobic probe 1-naphthylphenylamine by cells of P. aeruginosa was enhanced by rhamnolipid, as indicated by stopped-flow fluorescence experiments. Rhamnolipid did not stimulate the uptake rate of this probe in de-energized cells. These results indicate that an energy-dependent system is present in P. aeruginosa strain UG2 that mediates fast uptake of hydrophobic compounds in the presence of rhamnolipid.  (+info)

Effect of EDTA on Salmonella enterica serovar Typhimurium involves a component not assignable to lipopolysaccharide release. (6/96)

The effect of EDTA on Salmonella enterica serovar Typhimurium was studied in different growth phases with cells grown with or without Ca(2+) and Mg(2+) supplementation. EDTA affected the outer membrane much more strongly in the early exponential phase than in the mid- or late exponential phase, as indicated by uptake of 1-N-phenylnaphthylamine (a nonpolar hydrophobic probe, M(r) 219), and detergent (SDS) susceptibility. This effect was, however, not paralleled by LPS release (determined by measuring LPS-specific fatty acids or 14C-labelled LPS in cell-free supernatants, per a standardized cell density), which remained unchanged as a function of the growth curve. The conclusion from these results is that in the early exponential phase the effect of EDTA in S. enterica involves a component that is independent of LPS release.  (+info)

Neuroendocrine response to clonidine and 8-OH-DPAT in rats following chronic administration of desipramine or sertraline. (7/96)

1. Rats were administered either desipramine (DMI) or sertraline daily at doses 7.5 mg kg-1 or 10 mg kg-1, i.p., respectively and the effects on the functional state of hypothalamic neuroendocrine control mechanisms assessed by measurements of plasma hormones following acute drug challenge. The effects of treatment on gross behaviour and brain adrenoceptor density were also determined. 2. Both DMI and sertraline caused significant reduction in activity measured as ambulation and rearing at 14 days of treatment. 3. All animals were chronically cannulated after 14 days of treatment and tested for neuroendocrine response to acute i.v. clonidine (50 micrograms kg-1) or 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT, 250 micrograms kg-1) after 21 or more days of treatment. 4. Rats treated with DMI but not sertraline showed a virtually complete suppression of the growth hormone (GH) secretion elicited by clonidine in controls, while the secretion of corticosterone was augmented. 5. Treatment with DMI but not sertraline led to a significantly greater 8-OH-DPAT-induced secretion of prolactin than in the control rats, while the plasma concentrations of corticosterone following 8-OH-DPAT were not influenced by either DMI or sertraline treatment. 6. The density (but not the affinity) of cerebral cortical binding of [3H]-dihydroalprenolol was significantly reduced by DMI treatment. 7. These results show that DMI treatment blunted the sensitivity of post-synaptic alpha 2-adrenoceptors, accompanied by complex interactions manifested as increased responsiveness of alpha 1-adrenoceptors and 5-HT1A receptors. Sertraline had no significant neurendocrine effects at a dose which significantly reduced gross activity.  (+info)

The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. (8/96)

Inhibition of human cytochrome P4502D6 (CYP2D6)-catalysed metabolism can lead to clinically significant alterations in pharmacokinetics. Since there is evidence that the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs might inhibit CYP2D6, the effects of five SSRIs on human liver microsomal CYP2D6 activity were compared with each other and with three tricyclic antidepressant drugs. On a molar basis, paroxetine was the most potent of the SSRIs at inhibiting the CYP2D6-catalysed oxidation of sparteine (Ki = 0.15 microM), although fluoxetine (0.60 microM) and sertaline (0.70 microM) had Ki values in the same range. Fluvoxamine (8.2 microM) and citalopram (5.1 microM) also inhibited CYP2D6 activity. The major circulating metabolites of paroxetine in man produced negligible inhibition. In contrast, norfluoxetine the active metabolite of fluoxetine, was a potent CYP2D6 inhibitor (0.43 microM). CYP2D6 activity was also diminished by the tricyclic antidepressant drugs clomipramine (2.2 microM), desipramine (2.3 microM) and amitriptyline (4.0 microM). These findings suggest that compounds with SSRI activity are likely to interact with human CYP2D6 in vivo with the potential of causing drug interactions.  (+info)

Chem. Abstr. Name: N-Phenyl-2-naphthalenamine A. Evidence for carcinogenicity to humans (inadequate) No excess of bladder tumours was found among men in a rubber processing factory with known exposure to N-phenyl-2-naphthylamine (which contained small amounts of 2-naphthylamine); however, a study of rubber workers who were not exposed to 2-naphthylamine did show an increased incidence of bladder tumours. In the latter study, the men were exposed to several compounds, which probably included N-phenyl-2-naphthylamine [ref: 1]. B. Evidence for carcinogenicity to animals (limited) N-Phenyl-2-naphthylamine was tested for carcinogenicity by oral administration in mice, rats, hamsters and dogs. No carcinogenicity was reported in most experiments [ref: 1-4]. In one experiment, the total tumour incidence and the incidence of hepatocellular tumours were increased in male mice of one strain [ref: 1]. In another experiment, two rare kidney tumours were seen in female mice [ref: 2]. Subcutaneous ...
In one study, in one factory, of men with known exposure to N-phenyl-2-naphthylamine in rubber processing under controlled conditions, there was no indication of an excess incidence of bladder tumours. However, a broader study of rubber workers who had no exposure to 2-naphthylamine has shown an increased risk of bladder tumours. In the latter study, exposure was mixed but probably included exposure to N-phenyl-2-naphthylamine for many workers. These findings do not permit an assessment of the presence or absence of an elevated risk for cancer of the urinary bladder in persons exposed to N-phenyl-2-naphthylamine. 1 Subsequent to the finalization of this evaluation by the Working Group in June 1977, the Secretariat became aware of an abstract of a paper by Checkoway et al. (1977) describing a retrospective cohort mortality study of bladder cancers in 4 major US rubber companies between 1964-1973; however, the study cannot be evaluated on the basis of the data presented.. Subsequent evaluation: ...
N-Phenyl-1-naphthylamine C16H13NN-Phenyl-1-naphthylamines production and use as an antioxidant in various lubrication oils and as both a protective agent and
1-Naphthylamine hydrochloride 552-46-5 route of synthesis, 1-Naphthylamine hydrochloride chemical synthesis methods, 1-Naphthylamine hydrochloride synthetic routes ect.
2-naphthylamine 91-59-8 Precursor and Downstream products, 2-naphthylamine Precursor products, 2-naphthylamine Downstream products ect.
... aims at providing comprehensive data on n-(2-hydroxyethyl)-α-naphthylamine
Benzamide, 4-bromo-N-(1H-indol-3-ylphenylmethyl)-N-phenyl- | C28H21BrN2O | CID 71399214 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule 6-(cyclohexylmethoxy)-n-phenyl-1h-purin-2-amine (C18H21N5O) from the PQR.
Those results were in agreement with the antimicrobial and hemolytic activities of CODs. Moreover, we found that the studied peptides permeated both the outer and inner cytoplasmic membranes of Escherichia coli. This was determined by measuring changes in the fluorescence of probe N-phenyl-1-naphthylamine and detecting cytoplasmic β-galactosidase released during the interaction of peptides with E. coli cells. Transmission electron microscopy revealed that treatment of E. coli with one of the COD analogs caused leakage of bacterial content mainly from the septal areas of the ...
The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
12236-11-2 R 79579 1,3-Dioxane, 2,4-dimethyl-6-phenyl- (3Z)-3-(2-furylmethylidene)-1H-indol-2-one Amines, C12-14-tert-alkyl, bis(4-((5-chloro-2-hydroxyphenyl)azo)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-))cobaltate(1-) (1:1) N-phenyl-6-(tribromomethyl)-1,3,5-triazine-2,4-diamine N-[(chloro-dipropan-2-yloxyphosphoryl-methylidene)amino]-4-methyl-aniline 10,11-dithiocyanatoundecanoic acid Androsol acetate Trihydrogen tris((4-((4-(diethylamino)phenyl)(4-(ethyl(3-sulphonatobenzyl)amino)-o-tolyl)methylene)-3-methylcyclohexa-2,5-dien-1-ylidene)(ethyl)(3-sulphonatobenzyl)ammonium), aluminium salt
NFC is the only domestic producer of PANA (n-phenyl-1-naphthylamine), an anti-oxidant used in synthetic lubricants, rubber products and as an organic intermediate. Three options offered are molten liquid, solid and flake ...
Dr. Jing Zhang, Post-doctoral fellow (2013-16) Novel diagnostic tools for blast trauma, pre-symptomatic acute infectious disease and severe stress. Dr. Diana Campbell, Doctoral thesis (2012-16) Cross-regulation between thyroid and androgen hormones in amphibians. Dr. Sonja Bissegger, Doctoral thesis (2013-16) Role of 5 alpha-reductase type 3 and 5 beta-reductase in reproduction. Melody Kang, NSERC-USRA student (2016) DNA methylation in fish. Marie Sereneo, Honours thesis (2015-16) Effect s of diluted bitumen in rainbow trout. Tyler Rozario, Biotechnology placement student (2016) from St. Lawrence College, Kingston, ON. Giselle Hunt, NSERC-USRA student (2015) Analyzing the effects of dietary N-Phenyl-1-naphthylamine in snapping turtles (Chelydra sepentina). Steven Davis, SWEP student (2015) Animal care facility manager. Sean Chisnell, Biotechnology placement student (2015) from St. Lawrence College, Kingston, ON. Nova Zhao, NSERC-USRA student (2014) Development of in situ hybridization assays to ...
Wet-lab validated real-time PCR primer assays for your biological pathway of interest. Select your gene target of interest using an interactive pathway map, and select your plate.
(2-(4-(2-benzimidazol-2ylthio)ethyl)piperazin-1yl)-N-(2,4-bis(methylthio)-6-methyl-3-pyridyl)acetamide: a selective ACAT-1 inhibitor that suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels; structure in first source
77562-96-0 - BNTJVEIUADBJII-UHFFFAOYSA-N - Propanamide, N-(1-methyl-2-(4-(1-methylethyl)-1-piperazinyl)ethyl)-N-phenyl-, ethanedioate, hydrate (2:4:1) - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Sulfonation products of (N-phenyl-4-[[4-(phenylamino)phenyl][4-(phenylimino)cyclohexa-2,5-dien-1-ylidene]methyl]aniline, monohydrochloride and 4,4-[(4-iminocyclohexa-2,5-dien-1-ylidene)methylene]bis[N-phenylaniline], monohydrochloride), sodium salts ...
Chemical name:N-Phenyl-β-NaphthylamineMolecular formula:C16H13N Molecular structure: Molecular weight:219.29 CAS NO.:135-88-6Executive standard:Q/12HG 4521
Looking for Brönner's acid? Find out information about Brönner's acid. C10H6 SO3H A colorless, water-soluble naphthylamine sulfonic acid that forms needle crystals; used in dyes. Also spelled Broenners acid Explanation of Brönner's acid
good quality strength mineral rack gold ore flotation cell Simply said a Flotation Collectors is a chemical used to make the surface of minerals which is metallic hydrophobic or in layman s term afraid of water or water hating as others like to say This chemical used will behaved in a way as a wax would when you applied it to your car After wax or hydrophobic agent is adhered to Get Price ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Pantoprazole Sodium Sesquihydrate ;. Sodium 5-(difluoromethoxy)-2-[(RS)-[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl]benzimidazol-1-ide ;. CAS # 138786-67-1 (anhydrous) ; 164579-32-2 (sesquihydrate) ; 718635-09-7 (hydrate) ;. C16H14F2N3NaO4S (anhydrous) ; MW: 405.35 ;. C16H14F2N3NaO4S . 1.5 H2O ; Mol. Wt.: 432.40. Supplied as sesquihydrate for lab research use (not for human use) ;. ...
TY - JOUR. T1 - Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe. AU - Dong, Lei. AU - Zang, Yi. AU - Zhou, Dan. AU - He, Xiao Peng. AU - Chen, Guo Rong. AU - James, Tony D.. AU - Li, Jia. PY - 2015/7/28. Y1 - 2015/7/28. N2 - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.. AB - With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.. UR - http://www.scopus.com/inward/record.url?scp=84936970791&partnerID=8YFLogxK. UR - http://dx.doi.org/10.1039/c5cc04357c. U2 - 10.1039/c5cc04357c. DO - ...
No detectable medication was present in any infant exposed to paroxetine or fluvoxamine. Detectable medication (parent and/or metabolite) was present in 24% (8/33) of the serum samples obtained from infants exposed to sertraline. Concentrations of sertraline and desmethylsertraline, when present, were 2-8 and 2-12 ng/ml, respectively.. Four mothers (nos 5, 16, 24 and 49) titrated their dose of the antidepressant upwards to help their mood and obtained repeat serum samples on themselves and their infants after being on the higher medication dosage for at least 1 week.. Maternal dosage of sertraline correlated highly with infant serum concentration of desmethylsertraline after controlling for infant age, gestational exposure and breast-feeding exposure (parameter estimate=0.09, d.f.=1, P=0.03). Maternal serum concentrations of sertraline and desmethylsertraline correlated highly with infant serum concentration of desmethylsertraline (parameter estimate=0.20, d.f.=1, P,0.001 and parameter ...
HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS - diagram, schematic, and image 32 ...
Materials. 17-Allylamino-demethoxygeldanamycin (17-AAG) was provided by the National Cancer Institute and Kosan Biosciences (Hayward, CA). 2,6-Dichlorophenol-indophenol (DCPIP), NADH, NADPH, sodium borohydride, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), bovine serum albumin (BSA), β-lapachone, N-phenyl-1-naphthylamine, d(−)-penicillamine, and mouse monoclonal (IgG) and anti-actin antibodies were obtained from the Sigma Chemical Co. (St. Louis MO). Yeast Hsp90 and radicicol were obtained from Alexis (San Diego, CA). Human Hsp90 was a kind gift from Dr. David Toft (Mayo Clinic College of Medicine, Rochester, MN). Recombinant human NQO1 (rhNQO1) was purified from Escherichia coli as described previously ( 19). The activity of rhNQO1 was 4.5 μmol DCPIP/min/mg protein. Malachite green phosphate assay kit was obtained from BioAssay Systems, Inc. (Hayward, CA). Mouse anti-Hsp70 and rabbit anti-Raf-1 antibodies were obtained from Stressgen (Vancouver, British Columbia, ...
Page contains details about 1,8-naphthalimide derivative/cucurbit[8]urils nanovesicles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The effect of the polycation polyethyleneimine (PEI) on the permeability properties of the Gram-negative bacterial outer membrane was investigated using Escherichia coli, Pseudomonas aeruginosa and Salmonella typhimurium as target organisms. At concentrations of less than 20 μg ml-1, PEI increased the bacterial uptake of 1-N-phenylnaphthylamine, which is a hydrophobic probe whose quantum yield is greatly increased in a lipid environment, indicating increased hydrophobic permeation of the outer membrane by PEI. The effect of PEI was comparable to that brought about by the well-known permeabilizer EDTA. Permeabilization by PEI was retarded but not completely inhibited by millimolar concentrations of MgCl2. PEI also increased the susceptibility of the test species to the hydrophobic antibiotics clindamycin, erythromycin, fucidin, novobiocin and rifampicin, without being directly bactericidal. PEI sensitized the bacteria to the lytic action of the detergent SDS in assays where the bacteria were pretreated
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A pilot study looking at the potential impact of e-cigarettes on the health of those who use them found a strong correlation between vaping and the presence of two carcinogens known to cause bladder cancer. The preliminary study analyzed the urine of 13 e-cigarette users and 10 non-user controls. The e-cigarette users had a median of 26 months of use. Researchers found two known carcinogens, otoluidine and 2-naphthylamine, in the samples of all but one of the e-cigarette users. Neither toxin was found in the nonuser samples. The study suggests that e-cigarettes are not without their own risks, despite being ... Read More. ...
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glycyl-aspartyl-aspartyl-aspartyl-aspartyl-lysine-2-naphthylamide: synthetic substrate linked via amide bond to fluorophore 2-naphthylamine
Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make this pathology very variable and, consequently, a considerable challenge. Intriguingly, mitochondria have recently emerged as novel targets for cancer therapy. A group of agents with anti-cancer activity that induce apoptosis by way of mitochondrial destabilisation, termed mitocans, have been a recent focus of research. Of these compounds, many are hydrophobic agents that associate with various sub-cellular organelles. Clearly, modification of such structures with mitochondria-targeting moieties, for example tagging them with lipophilic cations, would be expected to enhance their activity. This may be accomplished by the addition of triphenylphosphonium groups that direct such compounds to mitochondria, enhancing their activity. In this paper, we will review agents that possess anti-cancer activity by way of destabilizing mitochondria and their possible targets. We propose that mitochondrial targeting, in
During your next cycle, we will work the clomid to mg. to be monitored days of your memory. We will. Joint for some encouragement bc DH murmurs on 1116 and we will have to other 6 more problems adipex and sertraline try again. He also gave me a good tip, he said after you get your toughest surge for ovulating, have sex the DAY Tinted in the blurred position being sure to keep your I coped cd and od adipex and sertraline cd still low and EWCM has advised away. I will keep BDing that i am sure, but just wondering if any of you found a rash as to how many days after your last Clomid choke that O came. I reveal most doctors like to see you ovulate around 5 - 9 adipex and sertraline after taking your last dose. More:. ...
Crystalline sertraline free base is made by treating a sertraline salt with a base and recovering the sertraline base in crystalline form.
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1994 Jul;38(1):33-8. PMID 7946934 Schäbitz WR, Li F, Fisher M. The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral ... 1-Naphthylamine is reacted with cyanogen bromide to give 2. Treatment of this intermediate with 3-ethyl-N-methylaniline leads ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. Journal of ... N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: A new, selective noncompetitive NMDA receptor antagonist". Journal of ...
Sudan Black is formed by coupling of diazotized 4-phenylazo-1-naphthylamine with 2,3-dihydro-2,2-dimethyl-1H-perimidine. ... Therefore the main product expected was 2,3-dihydro-2,2dimethyl-6-[(4-phenylazo-1-naphthalenyl)-azo]-1H-perimidine. However the ... HISTOCHEMISTRY AND CELL BIOLOGY Volume 16, Number 1 (1968), 68-84, DOI: 10.1007/BF00306212 Thin layer chrornatography and ... 1, SiO2) in thin Layer Chromatography). The above described product indeed turned out to be SSB-II which comprises up to 60% of ...
However, it is a weaker bidentate ligand as the nitrogen atom in the naphthylamine group is weakly coordinating due to the ... ethylenediamine undergoes most reactions typical to naphthylamine and primary amines such as diazotation. Similar to its analog ... N-(1-Naphthyl)ethylenediamine, also called a 'Griess reagent' is an organic compound. It is commercially available and finds ... This compound can be prepared by the reaction of 1-naphthylamine with 2-chloroethanamine. It is commercially available as the ...
2-Aminoindane 2-Aminotetralin 2-Naphthylamine Hathaway BA, Nichols DE, Nichols MB, Yim GK (May 1982). "A new, potent, ... 2-Amino-1,2-dihydronapthalene (2-ADN), also known as 2-aminodilin (2-AD), is a stimulant drug. It is a rigid analogue of ... It is closely related to 2-aminotetralin (2-amino-1,2,3,4-tetrahydronaphthalene), which also substitutes for amphetamine, and ... conformationally restricted analogue of amphetamine: 2-amino-1,2-dihydronaphthalene". Journal of Medicinal Chemistry. 25 (5): ...
4-tetrahydro-2-naphthylamine) Cyproheptadine [4-(5H-dibenz-[a,d]cyclohepten-5-ylidine)-1-methylpiperidine] Dasotraline ... This was the reason why sertraline was made only as monomethylated because apparently according to the orders the 1° amine is ... "A facile one-pot synthesis of 1-amino-4-aryl-tetralin derivatives by the CAN-induced (see also: CAN) cyclodimerization of ... Sarges, R; Koe, BK; Weissman, A; Schaefer, JP (December 1974). "Blockade of Heart 3H-Norepinephrine Up-take by 4-Phenyl-1- ...
Boyland E, Dukes CE, Grover PL (1963). "Carcinogenicity of 2-naphthylhydroxylamine and 2-naphthylamine". British Journal of ... 1 (6): 413-23. doi:10.1007/BF02633407. PMID 13609489. Dukes CE, Bussey HJ (1958). "The spread of rectal cancer and its effect ... 17 (1): 79-84. doi:10.1038/bjc.1963.12. PMC 2071273 . PMID 14014726. Boyland E, BUSBY ER, Dukes CE, Grover PL, Manson D (1964 ... 4 (1): 24-37. PMC 2238269 . PMID 18107178. Dukes CE (1949). "The significance of the unusual in the pathology of intestinal ...
... naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects ... 1P-ETH-LAD, 1-Propionyl-ETH-LAD 1P-LSD, 1-Propionyl-LSD ALD-52, 1-Acetyl-LSD AL-LAD, 6-Allyl-6-Nor-LSD ETH-LAD, 6-Ethyl-6-Nor- ... 32 (1): 41-51. doi:10.1007/s12020-007-9005-2. PMID 17992601. Kanno Y, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y (2013). " ... 27: 1-21. doi:10.1162/jocn_a_00776. PMID 25591060. The present meta-analysis was conducted to estimate the magnitude of the ...
For better differentiation, it is dipped in 1% acetic acid for 10-20 minutes until the colors are pure. This might take only 1- ... 73 (1): 32-8. doi:10.1562/0031-8655(2001)073. 2.0.CO;2. PMID 11202363. Kanitz, Andreas; Hartmann, Horst (1999). "Preparation ... The Nile blue staining, according to Kleeberg, uses the following chemicals: Nile Blue A 1% acetic acid Glycerol or glycerol ... 2-nitrosophenols with 1-naphthylamine, 3-(dialkylamino)phenols with N-alkylated 4-nitroso-1-naphtylamines, or N,N-dialkyl-1,4- ...
243: 1-13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262. Antoni R. Blaazer; et al. (October 2011). "Novel indole and ... It is suspected that metabolic hydrolysis of the amide group of NNE1 may release 1-naphthylamine, a known carcinogen, given the ... January 2015). "A case of death caused by abuse of a synthetic cannabinoid N -1-naphthalenyl-1-pentyl-1H -indole-3-carboxamide ... New Zealand Government Gazette, Notice Number 7051, 1 November 2012 Chizuko Sasaki; et al. ( ...
The molecular formula C12H13N (molar mass: 171.24 g mol−1, exact mass: 171.10480) may refer to: The drug rasagiline The dye N,N ... 1-naphthylamine More than 400 other chemical compounds "Empirical formula search for C12H13N". ChemSpider. Retrieved 15 April ...
... it is suspected that metabolic hydrolysis of the amide group of MN-18 may release 1-naphthylamine, a known carcinogen. MN-18 ...
Condensation of Michler's ketone with N-phenyl-1-naphthylamine gives the dye Victoria Blue B (CAS#2580-56-5, CI Basic Blue 26 ... Charles D. DeBoer, Nicholas J. Turro, and George S. Hammond (1973). "cis- and trans-1,2-Divinylcyclobutane". Organic Syntheses ... absorbs intensely at 366 nm and effectively sensitizes photochemical reactions such as the dimerization of butadiene to give 1, ...
5F-ADBICA 5F-SDB-006 AM-2201 FDU-NNE1 FUB-144 FUB-NNE1 MMB-2201 NNE1 PX-1 "5F-NNEI". Southern Association of Forensic ... it is suspected that metabolic hydrolysis of the amide group of 5F-NNE1 may release 1-naphthylamine, a known carcinogen. ...
2-naphthylamine MeSH D04.615.638.870 --- 1-naphthylisothiocyanate MeSH D04.615.638.900 --- naphthylvinylpyridine MeSH D04.615. ... vitamin k 1 MeSH D04.615.638.721.374.844 --- vitamin k 2 MeSH D04.615.638.721.374.922 --- vitamin k 3 MeSH D04.615.638.845 --- ... 10-dimethyl-1,2-benzanthracene MeSH D04.615.149.500 --- methylcholanthrene MeSH D04.615.149.700 --- perylene MeSH D04.615. ... 1-naphthylamine MeSH D04.615.638.845.800 --- sertraline MeSH D04.615.638.850 --- ...
Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 260 Hayes, W.J., Jr., E.R. Laws, Jr., (eds.). Handbook of Pesticide ... Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V16 987 (1995) Cunningham, A. L., and J. V. Hurley. "Alpha‐ ... 1981., p. 1-2 NIOSH. NIOSH Pocket Guide to Chemical Hazards & Other Databases. U.S. Department of Health & Human Services, ... The usual method is the reaction of 1-naphthylamine hydrochloride with ammonium thiocyanate: [C10H7NH3]Cl + NH4SCN → C10H7NHC(S ...
2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... 2-naphthylamine) Bis(chloromethyl)ether Chloromethyl methyl ether 1,3-Butadiene 1,4-Butanediol dimethanesulfonate (Busulphan, ... 2-Naphthylamine Neutron radiation Nickel compounds2 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) N- ... The Working Group concluded that acetaldehyde associated with alcohol consumption is carcinogenic to humans (Group 1) and ...
... is prepared by heating 2-naphthol with ammonium zinc chloride to 200-210 °C, the Bucherer reaction. It also can ... 2-Naphthylamine is found in cigarette smoke and suspected to contribute to the development of bladder cancer. It is activated ... 2-Naphthylamine is one of two isomeric aminonaphthalenes, compounds with the formula C10H7NH2. It is a colorless solid, but ... When reduced by sodium in boiling amyl alcohol solution, it forms tetrahydro-3-naphthylamine, which exhibits the properties of ...
... the naphthylamine steam-distilled. It can also be prepared, in the form of its acetyl derivative, by heating 1-naphthol with ... 1-Naphthylamine is an aromatic amine derived from naphthalene.It can cause Bladder Cancer. It crystallizes in colorless needles ... It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid at about 70 °C. After the reaction mixture is ... Hydrolysis at 200 °C in sulfuric acid, it converts to 1-naphthol. The sulfonic acid derivatives of 1-naphthylamine are used for ...
... is used in the nitrate reductase test to form a red precipitate of Prontosil by reacting with a ... N,N-Dimethyl-1-naphthylamine is an aromatic amine. It is formally derived from 1-naphthylamine by replacing the hydrogen atoms ... "N,N-dimethylnaphthalen-1-amine". ChemSpider. Retrieved 15 April 2010. "D4011 N,N-Dimethyl-1-naphthylamine, ≥98.0% (GC)". Sigma- ...
The amidine formed with 2-naphthylamine and the dimethyl sulfate adduct can be cyclized with sodium methoxide to give benzo[f] ... 5 (1): pp. 10-13, doi:10.5923/j.ajoc.20150501.02 EP 0731094, H.-J. Wroblowsky, R. Lantzsch, "Verfahren zur Herstellung von ... The vinamidinium salt 1,1,5,5-tetramethyl-1,5-diazapentadienium chloride reacts with heterocycles bearing CH-acidic groups to ... The same vinamidinium salt 1,1,5,5-tetramethyl-1,5-diazapentadienium chloride is also formed in the reaction of 3- ...
... but these effects are now attributed to naphthylamines, not anilines.[6] ... Collective Volume, 1, p. 82. *^ "Aniline". The Chemical Market Reporter. Archived from the original on 2002-02-19. Retrieved ... a b c D J Th Wagener, The History of Oncology (Houten: Springer, 2009), pp 150-1. ... 978-1-118-90637-8. . OCLC 957525299.. CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link). ...
The Bucherer reaction in organic chemistry is the reversible conversion of a naphthol to a naphthylamine in the presence of ... The enamine eliminates sodium bisulfite with formation of naphthylamine 6. It is important to stress that this is a reversible ... in German). 69 (1): 49-91. doi:10.1002/prac.19040690105. Seeboth, Habil H. (1967). "The Bucherer Reaction and the Preparative ... 1. pp. 63-90. doi:10.1002/0471264180.or001.05. ISBN 9780471264187. Pötsch, Winfried R.; Fischer, Annelore; Müller, Wolfgang ( ...
Victoria blues are members of the triarylmethane dyes, but unlike most such dyes, the Victoria blues have an naphthylamine ... Victoria Blue BO base, also known as Solvent Blue 5 and C.I. 42595:1, is the hydroxide derivative of the same cation. Its ...
... is prepared by oxidative cross coupling of 2-naphthol and 2-naphthylamine. The oxidative source is metal ions in solution ... NOBIN (2-amino-2'-hydroxy-1,1'-binaphthyl) is an organic molecule used for asymmetric catalysis. NOBIN is related to BINOL and ...
... rosinduline from benzeneazo-a-naphthylamine and aniline and naphthinduline from benzeneazo-a-naphthylamine and naphthylamine. ... Isorosinduline is obtained from quinone dichlorimide and phenyl-13-naphthylamine; ... The indulines may be subdivided into the following groups: (1) benzindulines, derivatives of phenazine; (2) isorosindulines; ...
Anilines and naphthylamines form more stable diazonium salts, which can be isolated in the crystalline form.[14] Diazonium ... 1. ,. :. ⏟. a. m. i. n. e. +. R. 3. −. C. O. ‖. −. OH. ⏟. carboxylic acid. −. ,. H. −. N. +. ,. R. 2. R. 1. ,. −. H. +. R. 3. − ... 1. ,. −. C. O. ‖. −. R. 3. ⏟. a. m. i. d. e. +. H. 2. O. ⏟. w. a. t. e. r. {\displaystyle {\underbrace {\ce {H-\!\!{\overset {\ ... ˈæmiːn/,[1][2] UK also /ˈeɪmiːn/)[3] are compounds and functional groups that contain a basic nitrogen atom with a lone pair. ...
... the naphthylamine steam-distilled. It can also be prepared, in the form of its acetyl derivative, by heating 1-naphthol with ... 1-Naphthylamine is an aromatic amine derived from naphthalene.It can cause Bladder Cancer. It crystallizes in colorless needles ... It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid at about 70 °C. After the reaction mixture is ... Hydrolysis at 200 °C in sulfuric acid, it converts to 1-naphthol. The sulfonic acid derivatives of 1-naphthylamine are used for ...
N-phenyl-1-naphthylamine  Koennecker, G; Mangelsdorf, Inge; Wibbertmann, A; World Health Organization; Inter-Organization ...
N,N-Dimethyl-1-naphthylamine is used in the nitrate reductase test to form a red precipitate of Prontosil by reacting with a ... N,N-Dimethyl-1-naphthylamine is an aromatic amine. It is formally derived from 1-naphthylamine by replacing the hydrogen atoms ... "N,N-dimethylnaphthalen-1-amine". ChemSpider. Retrieved 15 April 2010. "D4011 N,N-Dimethyl-1-naphthylamine, ≥98.0% (GC)". Sigma- ...
... naphthylamine-5-sulfonic acid products. View information & documentation regarding N-(Iodoacetaminoethyl ... naphthylamine-5-sulfonic acid, including CAS, MSDS & more. ... Synonym: 1,5-I-AEDANS, 5-. [2-. (Iodoacetamido). ethylamino]. naphthalene-. 1-. sulfonic acid, N-Iodoacetyl-N′-(5-sulfo-1- ... You have selected the maximum number of product attributes (%1%) to compare. Please remove at least one to add a new selection. ...
1,2,3,4-tetrahydro-1-naphthylamine. Regulatory process names 1 CAS names 1 IUPAC names 2 Other identifiers 2 ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ...
2-naphthylamine. ↓Other names: Regulatory process names [2] IUPAC names [2] ... N-Ethyl-1-(4-(phenylazo)phenylazo)-2-naphthylamine * N-ethyl-1-[(E)-2-{4-[(E)-2-phenyldiazen-1-yl]phenyl}diazen-1-yl]naphthalen ... 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be ...
N-Phenyl-Alpha Naphthylamine - Phenyl Alpha Naphthylamine .. On offer from us is Phenyl Alpha Naphthylamine Chemical, which is ... N-Phenyl-2-naphthylamine , C16H13N - PubChem. Using an initial concn of 100 mg/L N-phenyl-2-naphthylamine, 0 %BOD was observed ... 2-Naphthylamine-8- Hydroxy-6-Sulfonic Acid . 239 : C 10 H 9 N 1 O 4 S 1: Intermediates for Dyestuffs : Laurents Acid 1- ... N-(2-Dimethylaminoethyl)-N-Ethyl-M-Toluidine ; TOLUZONE BASE: 36790-28-0: 4-CHLORO RESORCINOL (4CRN) 95-88-5: 2-Naphthylamine-4 ...
You can also browse global suppliers,vendor,prices,Price,manufacturers of 1-Naphthylamine hydrochloride(552-46-5). At last,1- ... Naphthylamine hydrochloride(552-46-5) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need. ... Visit ChemicalBook To find more 1-Naphthylamine hydrochloride(552-46-5) information like chemical properties,Structure,melting ... 1-Naphthylamine hydrochloride. CAS No.. 552-46-5. Chemical Name:. 1-Naphthylamine hydrochloride. Synonyms. 1-NaphthylamineHCl;1 ...
Naphthylamine is the naphthalene homologues of aniline. Naphthylamine is the starting material in the dye manufacturing and ... Naphthylamine is an aromatic amine which can be obtained from nitronaphthalene (with iron and hydrochloric acid) or naphthol ... Naphthylamine can be oxidized by chromic acid into naphthoquinone which is the fundamental ring structure related with vitamin ... 2-Naphthylamine was used as an Intermediate for wide application target molecules including dyestuffs, agrochemicals, and ...
8-Naphthylamine-1-Sulfonic Acid (CAS 36930-64-0), a fluorescent thiol-reactive reagent, from Santa Cruz Biotechnology. ... N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid (CAS 36930-64-0) *bvseo_sdk, java_sdk, bvseo-3.2.0 ... N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid A fluorescent thiol-reactive reagent *Home. ... N-(Iodoacetylaminoethyl)-8-Naphthylamine-1-Sulfonic Acid is a fluorescent sulfhydryl reagent that is sensitive to photo ...
1-nitro-2-naphthylamine ; physical and chemical property of 606-57-5, 1-nitro-2-naphthylamine is provided by ChemNet.com ... 2-Naphthylamine, 1-nitro-; 1-Nitro-2-naphthylamine; 2-Amino-1-nitronaphthalene; 4-12-00-03184 (Beilstein Handbook Reference); ... CAS No: 606-57-5, Chemical Name: 1-nitro-2-naphthylamine. Home , Products , Suppliers , Offer to Buy , Offer to Sell , Chemical ... Gold Suppliers(1):. 1Hebei Smart Chemicals (Group) Co. Ltd.. Related selling offers. ...
Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr ...
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N-Phenyl-Alpha Naphthylamine - Phenyl Alpha Naphthylamine .. On offer from us is Phenyl Alpha Naphthylamine Chemical, which is ... N-Phenyl-beta-Naphthylamine may damage the liver. IDENTIFICATION N-Phenyl-beta-Naphthylamine is a light tan or gray flake or ... N-PHENYL-beta- NAPHTHYLAMINE HAZARD SUMMARY N …. * N-Phenyl-beta-Naphthylamine may cause a skin allergy. If allergy develops, ... N-Phenyl-2-naphthylamine (IARC Summary & Evaluation .. Similarly, the urine of workers exposed to N-phenyl-2-naphthylamine was ...
The method described is based on derivatization of selenocysteine with N-(iodoacetylaminoethyl)-5-naphthylamine-1-sulfonic acid ... N2 - The method described is based on derivatization of selenocysteine with N-(iodoacetylaminoethyl)-5-naphthylamine-1-sulfonic ... AB - The method described is based on derivatization of selenocysteine with N-(iodoacetylaminoethyl)-5-naphthylamine-1-sulfonic ... abstract = "The method described is based on derivatization of selenocysteine with N-(iodoacetylaminoethyl)-5-naphthylamine-1- ...
Prediction : 1-o-tolylazo-2-naphthylamine - albumin. Your feedback has been submited, thank you! ... 5-acetoxy-1-benzyl-2-methyl-indole-3-carboxylic-acid-ethyl-ester-albumin.html ... The value ranges from 0 to 1, with 1 being identical to the original X-Ray compound. ...
1-Naphthylamine hydrochloride 552-46-5 route of synthesis, 1-Naphthylamine hydrochloride chemical synthesis methods, 1- ... Current Page: Home › Chemical Dictionary › 552-46-5 › 1-Naphthylamine hydrochloride 552-46-5 Synthesis Route ... 1-Naphthylamine hydrochloride 552-46-5 Synthesis RouteTotal: 4 Synthesis Route ...
1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride - Similar structures search, synonyms, formulas, resource links, ... Substance Name: 2-Naphthylamine, 1,2,3,4-tetrahydro-2-benzyl-N,4,4-trimethyl-, hydrochloride. RN: 31209-75-3. InChIKey: ... 1S/C20H25N.ClH/c1-19(2)15-20(21-3,13-16-9-5-4-6-10-16)14-17-11-7-8-12-18(17)19;/h4-12,21H,13-15H2,1-3H3;1H. Download. ...
ManufacturersRubber Antioxidant BLE in tire cas 68412-48-6 Liquid N-Phenyl-1-naphthylamine Antioxidant BLE. US $10.00 ... It has good resistance to heat、oxygen、bending,fatigue ageing, and can replace phenyl-α-naphthylamine、phenyl-β-naphthylamine. It ... Axe on Twitter 1 Dr. Axe on Instagram Dr. Axe on Google Plus Dr. Axe on Youtube Dr. Axe on Pintrest 89 Share on Email Print ... liquid n-phenyl-1-naphthylamine antioxidant ble for tyre making. *. Alibaba Manufacturer Directory Suppliers, Manufacturers. ...
1-Naphthylamine-7-sulfonic acid 119-28-8 MSDS report, 1-Naphthylamine-7-sulfonic acid MSDS safety technical specifications ... search, 1-Naphthylamine-7-sulfonic acid safety information specifications ect. ... 1-Naphthylamine-7-Sulfonic Acid 100 204-311-4 Hazard Symbols: XI Risk Phrases: 36/38 Section 3 - HAZARDS IDENTIFICATION. ... 1-Naphthylamine-7-Sulfonic Acid - Not listed by ACGIH, IARC, or NTP.. Section 12 - ECOLOGICAL INFORMATION. Section 13 - ...
N-Phenyl-1-naphthylamine C16H13NN-Phenyl-1-naphthylamines production and use as an antioxidant in various lubrication oils and ... RUBBER ANTIOXIDANT PBN(D) Chemical name: N-phenyl-2-naphthylamine Molecular Formula: C16H13N Molecular Weight: 219.28 CAS NO.: ... N-Phenyl-1-naphthylamines production and use as an antioxidant in various lubrication oils and as both a protective agent and ... China N- (1, 3-Dimethylbutyl) -N′-Phenyl-P. China N- (1, 3-Dimethylbutyl) -N′-Phenyl-P-Phenylenediamine (AO4020), Find details ...
Impurity: 1-NAPHTHYLAMINE. May cause an allergic skin reaction. Only in: Household Cleaners. ... Impurity: 1-NAPHTHYLAMINE. Fatal in contact with skin. Only in: Household Cleaners. ... Impurity: 1-NAPHTHYLAMINE. Toxic in contact with skin. Only in: Household Cleaners. ...
N-phenyl-1-naphthylamine  Koennecker, G; Mangelsdorf, Inge; Wibbertmann, A; World Health Organization; Inter-Organization ... AuthorInter-Organization Programme for the Sound Management of Chemicals (‎1)‎Koennecker, G (‎1)‎Mangelsdorf, Inge (‎1)‎ ... Dose-Response Relationship, Drug (‎1)‎Environmental Exposure (‎1)‎... View MoreDate Issued1998 (‎1)‎ ... Wibbertmann, A (‎1)‎World Health Organization (‎1)‎Subject 1-Naphthylamine (‎1)‎. ...
N-Phenyl-1-Naphthylamine CAS 90-30-2 FOB Price: US $ 5100-5300 / Ton. Min. Order: 1 Ton ... Smart Drug 9-Fluorenol CAS 1689-64-1 for Memory Improve FOB Price: US $ 1-3 / Piece. Min. Order: 10 Pieces ...
  • The sulfonic acid derivatives of 1-naphthylamine are used for the preparation of azo dye, these dyes possessing the important property of dyeing unmordanted cotton. (wikipedia.org)
  • Silver(I)-Catalyzed C4-H Amination of 1-Naphthylamine Derivatives with Azodicarboxylates. (nih.gov)
  • More speci?cally, it relates to (1) a process for the preparation of quaterm'zed heterocyclic azo dyes, (2) to a process for the deoxygenation of mon azine oxides by the action of certain metals in an inert 15 solvent, (3) to a process for the deoxygenation of mon-' azine oxides with phosphorous trichloride in halogenated aromatic solvents and (4) to certain new azo derivatives of monazine oxides. (docme.ru)
  • 2020, Accepted Manuscript DOI: 10.1039/D0OB00586J, PaperYaqi Shi, Fan Yang, Yangjie Wu A simple and efficient protocol for palladium-catalyzed C8-H alkoxycarbonylation of 1-naphthylamine derivatives with alkyl chloroformates has been developed, exhibiting broad functional group tolerance, high regioselectivity, and oxidant-free conditions. (medworm.com)
  • Paul, S. 1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: Synthesis and preliminary evaluation of biological properties. (eurekaselect.com)
  • 1-Naphthylammonium chloride for synthesis. (chemicalbook.com)
  • In Figure 1 , the words synthesis gas have been shown as the source of two products, ammonia and methanol . (britannica.com)
  • 2020, Accepted Manuscript DOI: 10.1039/D0OB00877J, PaperShuai-Shuai Jiang, Yu-Ting Xiao, Yan-Chen Wu, Shu-Zheng Luo, Ren-Jie Song, Jin-Heng Li A simple and practical method for the synthesis of phosphoryl-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and benzimidazo[2,1-a]isoquinolin-6(5H)-ones through manganese(III)-promoted tandem phosphinoylation/cyclization of 2-arylindoles or 2-arylbenzimidazoles with disubstituted phosphine oxides was developed. (medworm.com)
  • Nitin, B.C. Synthesis and antimicrobial activities of 1-Naphthylamine based acetophenone semicarbazones. (eurekaselect.com)
  • Abdallah, O.A.A. Synthesis and reactions of n-chloromethyl-1,2,4-triazoles with sulfur and oxygen nucleophiles. (eurekaselect.com)
  • This is correct but it is an oversimplification in the sense that sertraline is the S , S -isomer whereas tametraline is the 1 R ,4 S -stereoisomer. (rug.nl)
  • This was the reason why sertraline was made only as monomethylated because apparently according to the orders the 1° amine is inactive therefore the drug would have a shorter duration of activity. (rug.nl)
  • 1. Protect employees from the health hazards presented by hazardous chemicals used in that particular work place and 2. (vims.edu)
  • Branched peptides carrying two copies of the putative sequence RGRKX 1 X 2 X 3 X 4 or RGX 1 X 2 X 3 X 4 RR, where X 1 -X 4 are natural or unnatural amino acid residues were synthesized and their antimicrobial properties and their ability to permeabilize the OM of P. aeruginosa were determined. (arvojournals.org)
  • Naturally occurring antimicrobial peptides (AMPs) are considered potential anti-infective agents primarily due to their antimicrobial or immunomodulatory properties [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. (pubmedcentralcanada.ca)
  • Polytetrahydrofuran mono ethers of C 1-20 -alcohols have also been disclosed in U.S. Pat. (google.com)
  • It is formally derived from 1-naphthylamine by replacing the hydrogen atoms on the amino group with methyl groups. (wikipedia.org)
  • The formation of 17-AAGH 2 was NQO1 dependent, and its formation could be inhibited by the addition of 5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione (ES936), a mechanism-based (suicide) inhibitor of NQO1. (aacrjournals.org)
  • No data were available on the genetic effects of N-phenyl-2-naphthylamine in humans. (marijkes-hobbyshop.nl)
  • N -Phenyl-2-naphthylamine is not classifiable as to its carcinogenicity to humans (Group 3) . (inchem.org)
  • Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 1: The agent (mixture) is carcinogenic to humans. (wikipedia.org)
  • Specific radionuclides for which there is sufficient evidence for carcinogenicity to humans are also listed individually as Group 1 agents. (wikipedia.org)
  • The Working Group concluded that acetaldehyde associated with alcohol consumption is carcinogenic to humans (Group 1) and confirmed the classification in Group 1 of alcohol consumption and of ethanol in alcoholic beverages. (wikipedia.org)
  • June 12, 2012 ‐‐ After a week-long meeting of international experts, the International Agency for Research on Cancer (IARC), which is part of the World Health Organization (WHO), today classified diesel engine exhaust as carcinogenic to humans (Group 1), based on sufficient evidence that exposure is associated with an increased risk for lung cancer "IARC Monographs evaluate consumption of red meat and processed meat" (PDF). (wikipedia.org)
  • Kinetics of photoenolization of 5,8-dimethyl-1-tetralone: Hydrogen-transfer tunnel-effects in the excited triplet state. (mpg.de)
  • N,N-Dimethyl-1-naphthylamine is used in the nitrate reductase test to form a red precipitate of Prontosil by reacting with a nitrite-sulfanilic acid complex. (wikipedia.org)
  • On offer from us is Phenyl Alpha Naphthylamine Chemical, which is used in the chemical industry as an intermediate for dyestuff and food colors.Processed under the strict supervision of our deft auditors, we have take intense care to match the purity standards of the industry. (steunmijnclub.nl)
  • As a professional China Rubber Antioxidant SP Liquid 61788-44-1 manufacturer, we supply rubber chemical, rubber additive as well as prepared rubber products with good price. (holebiwest.be)
  • Wastewater samples originating from an explosives production plant (3,000 mg N l −1 nitrate, 4.8 mg l −1 nitroglycerin, 1.9 mg l −1 nitroglycol and 1,200 mg l −1 chemical oxygen demand) were subjected to biological purification. (springer.com)
  • 1 College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an, China . (scirp.org)
  • COX-1 is expressed constitutively in most cells and involved in homeostasis, whereas COX-2 is not produced in normal tissues until being induced by chemical and physical stimulations and enhanced by oncogenes, growth factors, and cytokines [ 3 ]. (hindawi.com)
  • We synthesized a new HIL and HTL materials by using phenothiazinly moiety, 1,4-diphenothiazyl-benzene [DPtzB], 3′,7′,3″,7″-tetrakis(N-phenyl-2-naphthylamine)-1,4-diphenothiazyl-benzene [PNA-DPtzB]. (ingentaconnect.com)
  • 1-Nitronaphthalene smoothly reacts with benzene and undergoes selective reduction with cyclohexane in the presence of aluminum chloride to give 2,4,4-triphenyl-3,4-dihydronaphthalen-1(2 H )-one oxime and 5,6,7,8-tetrahydro-1-naphthylamine, respectively. (rsc.org)
  • beta naphthphenthiazine was prepared by mixing220 parts by weight of phenyl-beta naphthylamine (1 molecular equivalent), 66 parts of sulfur (2 molecular equivalents), and 10 parts of aluminum chloride. (google.es)
  • alpha naphthphenthiazine was prepared by heating together 50 A typical tire Elongation 4o sulfur and phenyl-alpha-naphthylamine in a manner similar to that given in Example 1. (google.es)
  • We have examined the role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the bioreductive metabolism of 17-allylamino-demethoxygeldanamycin (17-AAG). (aacrjournals.org)
  • 1-Naphthylamine is used in the manufactureof dyes and tonic prints. (chemicalbook.com)
  • Dyes and pigments are extensively used as they play an essential role in the textile, leather, plastic and paper industry [ 1 ]. (mdpi.com)
  • The three most commonly used dyes are azo, anthraquinone and phthalocyanine [ 1 ]. (mdpi.com)
  • 8-Amino-1-naphthalenesulfonic acid (CAS 82-75-7) Market Research Report 2017 aims at providing comprehensive data on 8-amino-1-naphthalenesulfonic acid market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • The report includes 8-amino-1-naphthalenesulfonic acid description, covers its application areas, manufacturing methods, patents. (marketpublishers.com)
  • Besides, the report provides 8-amino-1-naphthalenesulfonic acid prices in regional markets. (marketpublishers.com)
  • In addition to the above the report determines 8-amino-1-naphthalenesulfonic acid consumers. (marketpublishers.com)
  • 8-Amino-1-naphthalenesulfonic acid (CAS 82-75-7) Market Research Report 2017 contents were worked out and placed on the website in December, 2017. (marketpublishers.com)
  • Please note that 8-Amino-1-naphthalenesulfonic acid (CAS 82-75-7) Market Research Report 2017 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • Such dyestu?s, 60 5-, 1-amino-3-methylisoquinoline. (docme.ru)
  • It can be prepared by reducing 1-nitronaphthalene with iron and hydrochloric acid at about 70 °C. After the reaction mixture is neutralized with milk of lime, the naphthylamine steam-distilled. (wikipedia.org)