AnatomyChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
1-Carboxyglutamic AcidWarfarinVitamin KHeart Valve ProsthesisAnticoagulantsAortic ValveHeart ValvesHeart Valve Prosthesis Implantation
1-Carboxyglutamic Acid
Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.
Warfarin
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Vitamin K
A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
Heart Valve Prosthesis
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
Anticoagulants
Agents that prevent clotting.
Aortic Valve
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Heart Valves
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
Heart Valve Prosthesis Implantation
Surgical insertion of synthetic material to repair injured or diseased heart valves.

Undercarboxylation of recombinant prothrombin revealed by analysis of gamma-carboxyglutamic acid using capillary electrophoresis and laser-induced fluorescence. (1/185)

The gamma-carboxyglutamic acid (Gla) content of several variants of human prothrombin has been measured by using capillary electrophoresis and laser-induced fluorescence (CE-LIF). Both plasma-derived prothrombin and recombinant prothrombin contain ten residues of Gla per molecule of protein. In contrast, a variant of human prothrombin (containing the second kringle domain of bovine prothrombin) was separated into two populations that differed in their Gla content. Direct measurement of the Gla content showed an association with the presence or absence of the calcium-dependent conformational change that is required for prothombinase function. Thus, the CE-LIF assay is useful in determining the carboxylation status of recombinant proteins.  (+info)

A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx. (2/185)

Cone snails are gastropod mollusks of the genus Conus that live in tropical marine habitats. They are predators that paralyze their prey by injection of venom containing a plethora of small, conformationally constrained peptides (conotoxins). We report the identification, characterization, and structure of a gamma-carboxyglutamic acid-containing peptide, conotoxin epsilon-TxIX, isolated from the venom of the molluscivorous cone snail, Conus textile. The disulfide bonding pattern of the four cysteine residues, an unparalleled degree of posttranslational processing including bromination, hydroxylation, and glycosylation define a family of conotoxins that may target presynaptic Ca2+ channels or act on G protein-coupled presynaptic receptors via another mechanism. This conotoxin selectively reduces neurotransmitter release at an Aplysia cholinergic synapse by reducing the presynaptic influx of Ca2+ in a slow and reversible fashion. The three-dimensional structure, determined by two-dimensional 1H NMR spectroscopy, identifies an electronegative patch created by the side chains of two gamma-carboxyglutamic acid residues that extend outward from a cavernous cleft. The glycosylated threonine and hydroxylated proline enclose a localized hydrophobic region centered on the brominated tryptophan residue within the constrained intercysteine region.  (+info)

Calcium binding mode of gamma-carboxyglutamic acids in conantokins. (3/185)

Conantokin-T (con-T) and conantokin-G (con-G) are two highly homologous peptide toxins found in Conus venom. The former is a 21-residue peptide with four gamma-carboxyglutamic acid (Gla) residues (at positions 3, 4, 10 and 14), while the latter is a 17-residue peptide with five gamma-carboxyglutamic acid residues (at positions 3, 4, 7, 10 and 14). Despite the apparent similarity in number and relative positions of the gamma-carboxyglutamic acid residues, (113)Cd-NMR studies indicated a distinct metal binding behavior for con-G and con-T. There appears to be four binding sites in con-G in contrast to one metal binding site in con-T. To elucidate the mode of calcium binding by the gamma-carboxyglutamic acid residues in these conantokins, we designed various analogous peptides with their gamma-carboxyglutamic acid replaced by other amino acid residues. (113)Cd-NMR experiments on conantokin analogues reveal that the major difference in the number of metal binding sites between con-G and con-T is due to the residue at position 7. We also performed molecular simulations to calculate the relative binding free energies of several potential binding sites. Based on our theoretical and experimental results, we propose a 'four-site' binding model for conantokin-G and a 'single-site' binding model for conantokin-T.  (+info)

Expression of the gene encoding the matrix gla protein by mature osteoblasts in human fracture non-unions. (4/185)

BACKGROUND: Osteoblast phenotypic abnormality, namely the expression of collagen type III, has been shown previously in fracture non-union woven bone. AIMS: To investigate osteoblasts from fracture non-unions for evidence of gene expression of non-collagenous bone matrix proteins that have been implicated in mineralisation, namely matrix gla protein (MGP), osteonectin, osteopontin, and osteocalcin. MGP is a consistent component of bone matrix, but there are no reports of osteoblasts in the skeleton expressing the gene for MGP, and the site of synthesis of skeletal MGP (perhaps the liver) has yet to be determined. METHODS: Biopsies from normally healing human fractures and non-unions were examined by means of in situ hybridisation, using 35S labelled probes and autoradiography to disclose levels of gene expression. RESULTS: In normally healing fractures, mature osteoblasts on woven bone were negative for MGP mRNA, but positive for osteonectin, osteopontin, and osteocalcin mRNA molecules. In non-unions, osteoblasts displayed a novel phenotype: they were positive for MGP mRNA, in addition to osteonectin, osteopontin, and osteocalcin mRNA molecules. CONCLUSIONS: Mature osteoblasts in slowly healing fractures have an unusual phenotype: they express the gene encoding MGP, which indicates that control of osteoblast gene expression in non-unions is likely to be abnormal. This might be of importance in the pathogenesis of non-uniting human fractures, and is of current interest given the emerging status of MGP as an inhibitor of mineralisation.  (+info)

Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. (5/185)

Matrix GLA protein (MGP), a gamma-carboxyglutamic acid (GLA)-rich, vitamin K-dependent and apatite-binding protein, is a regulator of hypertrophic cartilage mineralization during development. However, MGP is produced by both hypertrophic and immature chondrocytes, suggesting that MGP's role in mineralization is cell stage-dependent, and that MGP may have other roles in immature cells. It is also unclear whether MGP regulates the quantity of mineral or mineral nature and quality as well. To address these issues, we determined the effects of manipulations of MGP synthesis and expression in (a) immature and hypertrophic chondrocyte cultures and (b) the chick limb bud in vivo. The two chondrocyte cultures displayed comparable levels of MGP gene expression. Yet, treatment with warfarin, a gamma-carboxylase inhibitor and vitamin K antagonist, triggered mineralization in hypertrophic but not immature cultures. Warfarin effects on mineralization were highly selective, were accompanied by no appreciable changes in MGP expression, alkaline phosphatase activity, or cell number, and were counteracted by vitamin K cotreatment. Scanning electron microscopy, x-ray microanalysis, and Fourier-transform infrared spectroscopy revealed that mineral forming in control and warfarin-treated hypertrophic cell cultures was similar and represented stoichiometric apatite. Virally driven MGP overexpression in cultured chondrocytes greatly decreased mineralization. Surprisingly, MGP overexpression in the developing limb not only inhibited cartilage mineralization, but also delayed chondrocyte maturation and blocked endochondral ossification and formation of a diaphyseal intramembranous bone collar. The results show that MGP is a powerful but developmentally regulated inhibitor of cartilage mineralization, controls mineral quantity but not type, and appears to have a previously unsuspected role in regulating chondrocyte maturation and ossification processes.  (+info)

Identification of organic phosphorus covalently bound to collagen and non-collagenous proteins of chicken-bone matrix. The presence of O-phosphoserine and O-phosphothreonine in non-collagenous proteins, and their absence from phosporylated collagen. (6/185)

Non-collagenous phosphoproteins, almost all of which can be extracted in EDTA at neutral pH in the presence of proteinase inhibitors, are identified in the matrix of chicken bone, and are therefore not covalently bound to collagen. Similarly, all the peptides containing gamma-carboxyglutamic acid are present in the EDTA extract and none in the insoluble residue, confirming that none is covalently linked to chicken bone collagen. However, organic phosphorus is also found to be present in chicken bone collagen, principally in the alpha2-chains. Of the total protein-bound organic phosphorus present in chicken bone matrix, approx. 80% is associated with the non-collagenous proteins and 20% with collagen. The soluble non-collagenous proteins contain both O-phosphoserine and O-phosphothreonine and these account for essentially of their organic phosphorus content. In contrast, collagen contains neither O-phosphoserine nor O-phosphothreonine. Indeed, no phosphorylated hydroxy amino acid, phosphoamidated amino acid or phosphorylated sugar could be identified in purified components of collagen, which contain approximately four to five atoms of organic phosphorus per molecule of collagen. Peptides containing organic phosphorus were isolated from partial acid hydrolysates and enzymic digests of purified collagen components, which contain an as-yet-unidentified cationic amino acid. These data, the very high concentrations of glutamic acid in the phosphorylated peptides, and the pH-stability of the organic phosphorus moiety in intact collagen chains strongly suggest that at least part of the organic phosphorus in collagen is present as phosphorylated glutamic acid. This would indicate that the two major chemically different protein fractions in chicken bone matrix that contain organic phosphorus may represent two distinct metabolic pools of organic phosphorus under separate biological control.  (+info)

Identification and purification of vitamin K-dependent proteins and peptides with monoclonal antibodies specific for gamma -carboxyglutamyl (Gla) residues. (7/185)

Novel monoclonal antibodies that specifically recognize gamma-carboxyglutamyl (Gla) residues in proteins and peptides have been produced. As demonstrated by Western blot and time-resolved immunofluorescence assays the antibodies are pan-specific for most or all of the Gla-containing proteins tested (factors VII, IX, and X, prothrombin, protein C, protein S, growth arrest-specific protein 6, bone Gla protein, conantokin G from a cone snail, and factor Xa-like proteins from snake venom). Only the Gla-containing light chain of the two-chain proteins was bound. Decarboxylation destroyed the epitope(s) on prothrombin fragment 1, and Ca(2+) strongly inhibited binding to prothrombin. In Western blot, immunofluorescence, and surface plasmon resonance assays the antibodies bound peptides conjugated to bovine serum albumin that contained either a single Gla or a tandem pair of Gla residues. Binding was maintained when the sequence surrounding the Gla residue(s) was altered. Replacement of Gla with glutamic acid resulted in a complete loss of the epitope. The utility of the antibodies was demonstrated in immunochemical methods for detecting Gla-containing proteins and in the immunopurification of a factor Xa-like protein from tiger snake venom. The amino acid sequences of the Gla domain and portions of the heavy chain of the snake protein were determined.  (+info)

Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R. (8/185)

Conantokin-R (con-R), a gamma-carboxyglutamate-containing 27-residue peptide, is a natural peptide inhibitor of the N-methyl-d-aspartate (NMDA) subtype glutamate receptor. Synthetic analogs of con-R were generated to evaluate the importance of the individual structural elements of this peptide in its NMDA receptor antagonist activity, measured by inhibition of the spermine-enhanced binding of the NMDA receptor-specific channel blocker, [(3)H]MK-801, to rat brain membranes. Progressive C-terminal truncations of the 27-residue peptide revealed stages of severe activity loss. These occurred at con-R[1-11] and con-R[1-7], corresponding to the deletions of Leu(12)-Pro(27) and Met(8)-Pro(27) respectively. A second set of analogs featured single Ala substitutions in the fully active con-R[1-17] fragment. The replacement of Met(8) and Leu(12) by Ala resulted in approximate 20- and 55-fold decreases of inhibitor potency, respectively. In addition to these two residues, the only other positions where a single Ala substitution led to substantial losses (from 11-fold to >1000-fold) of activity were those of the first five N-terminal amino acids. Based on the above findings, the binding epitope of con-R was localized to the N-terminal turn of the helix and other residues on one face along two subsequent turns. This contribution pattern of the side chains in activity closely resembles the results obtained with another member of this peptide family, conantokin-T. The secondary structure and metal ion binding properties of the con-R variants were also evaluated using circular dichroism spectroscopy. Divalent cation-dependent increases of alpha-helix content were observed in most analogs. However, analogs with replacement of Gla(11) and Gla(15), as well as truncation fragments shorter than 15 residues, lost the ability to be stabilized by metal ions. These results confirmed the location of the primary divalent cation binding locus at Gla(11) and Gla(15). Additional interactions were indicated by the reduced alpha-helix stability in the Ala analogs of Gla(4), Lys(7), and Arg(14).  (+info)

Carboxyglutamic acid - WikipediaCarboxyglutamic acid - Wikipedia
Gamma-carboxyglutamic acid residues play an important role in coagulation. The high-affinity calcium binding sites in the GLA domain of factor IX, which is a serine protease of the coagulation system, were found to partially mediate the binding of factor IXa to platelets and in factor-X activation.[4] In addition, upon mechanical injury to the blood vessel wall, a cell-associated tissue factor becomes exposed and initiates a series of enzymatic reactions localized on a membrane surface generally provided by cells and accumulating platelets. Gla residues partly govern the activation and binding of circulating blood-clotting enzymes and zymogens to this exposed cell membrane surface. Specifically, gla residues are needed in calcium binding and in exposing hydrophobic membrane binding regions to the cell bilayer. Lack of these gla residues results in impaired coagulation or even anticoagulation, which may lead to bleeding diathesis or thrombosis.[5]. ...
https://en.wikipedia.org/wiki/%CE%93-carboxyglutamate
Matrix gla protein - WikipediaMatrix gla protein - Wikipedia
Matrix gla protein (MGP) is member of a family of vitamin-K2 dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. MGP is found in number body tissues in mammals, birds, and fish. Its mRNA is present in bone, cartilage, heart, and kidney. It is present in bone together with the related vitamin K2-dependent protein osteocalcin. In bone, its production is increased by vitamin D. The MGP was linked to the short arm of chromosome 12 in 1990. Its mRNA sequence length is 585 bases long in humans. MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires Vitamin K hydroquinone. This process also occurs with a number of proteins involved in ...
https://en.wikipedia.org/wiki/Matrix_gla_protein
RCSB PDB - 1CFH: STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY...RCSB PDB - 1CFH: STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY...
1CFH: Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by two-dimensional NMR spectroscopy.
http://www.rcsb.org/pdb/explore/explore.do?structureId=1CFH
PAA471Ra01 | 骨钙素(OC)多克隆抗体 | Rattus norvegicus (Rat，大鼠) USCN(武汉优尔生商贸有限公司)PAA471Ra01 | 骨钙素(OC)多克隆抗体 | Rattus norvegicus (Rat，大鼠) USCN(武汉优尔生商贸有限公司)
PAA471Ra01, Polyclonal Antibody to Osteocalcin (OC), 骨钙素(OC)多克隆抗体, BGLAP; OT; BGP; Bone Gla Protein; Bone Gamma-Carboxyglutamate Protein; Gamma-carboxyglutamic acid-containing protein | 仅供体外研究使用，不用于临床诊断！请索取进口关税税单及报关单！
http://www.uscnk.cn/uscn/Antibody-to-Osteocalcin-OC-11365.htm
Structure of Ca+2 -free Gla diomain shed light on membrane binding of blood coagulation proteins<...Structure of Ca+2 -free Gla diomain shed light on membrane binding of blood coagulation proteins<...
TY - JOUR. T1 - Structure of Ca+2 -free Gla diomain shed light on membrane binding of blood coagulation proteins. AU - Sunnerhagen, Maria. AU - Forsen, Sture. AU - Hoffren, Anna-Marja. AU - Drakenberg, Torbjörn. AU - Teleman, Olle. AU - Stenflo, Johan. N1 - Project code: B5SU00139. PY - 1995. Y1 - 1995. N2 - Reversible membrane binding of γ-carboxyglutamic acid (Gla)-containing coagulation factors requires Ca2+-binding to 10-12 Gla residues. Here we describe the solution structure of the Ca2+-free Gla-EGF domain pair of factor X which reveals a striking difference between the Ca2+-free and Ca2+-loaded forms. In the Ca2+-free form Gla residues are exposed to solvent and Phe 4, Leu 5 and Val 8 form a hydrophobic cluster in the interior of the domain. In the Ca2+-loaded form Gla residues ligate Ca22+ in the core of the domain pushing the side-chains of the three hydrophobic residues into the solvent. We propose that the Ca2+-induced exposure of hydrophobic side chains is crucial for membrane ...
https://cris.vtt.fi/en/publications/structure-of-ca2-free-gla-diomain-shed-light-on-membrane-binding-
Sriram Krishnaswamy | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of...
Vadivel, K., Agah, S., Messer, A.S., Cascio, D., Bajaj, M.S., Krishnaswamy, S., Esmon, C.T., Padmanabhan, K. and Bajaj, S.P.: Structural and Functional Studies of -Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium. J. Mol. Biol. 425: 1961-1981, 2013 ...
http://www.med.upenn.edu/apps/faculty/index.php/g275/p18400
MGP Polymorphism in Mexican Indians and Mestizos . . . by Guadalupe Hernandez-Pacheco, Luis Enrique Murguia et al.MGP Polymorphism in Mexican Indians and Mestizos . . . by Guadalupe Hernandez-Pacheco, Luis Enrique Murguia et al.
Matrix -carboxyglutamic acid protein (MGP) genotypes (G- 7A and T-138C) were determined in 266 individuals from three Mexican populations. Mexicans showed increased frequencies of the G-7A G allele and the G7-A GG genotype compared to Europeans. For the T-138C genotype, we found differences among the Mexicans. This study could help to define the significance of MGP polymorphisms as genetic markers in Amerindian populations.
http://digitalcommons.wayne.edu/humbiol/vol77/iss3/7/
Reactome | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusReactome | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
http://www.reactome.org/content/detail/159763
A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein...
TY - JOUR. T1 - A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment. AU - Lee, Wonhwa. AU - Seo, Junyoung. AU - Kwak, Soyoung. AU - Park, Eun Ji. AU - Na, Dong Hee. AU - Kim, Soyoun. AU - Lee, You Mie. AU - Kim, In-San. AU - Bae, Jong Sup. PY - 2015/11/1. Y1 - 2015/11/1. N2 - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.. AB - New protein nanocages are designed bearing two functional proteins, γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These ...
https://koreauniv.pure.elsevier.com/en/publications/a-double-chambered-protein-nanocage-loaded-with-thrombin-receptor
DESIGN OF MODIFIED PROTEIN C BY MOLECULAR MODELING | SBIR.govDESIGN OF MODIFIED PROTEIN C BY MOLECULAR MODELING | SBIR.gov
THE COAGULATION CASCADE CONSISTS OF A NUMBER OF MULTIDOMAIN SERINE PROTEASES AND PROTEIN COFACTORS. AMONG THESE ARE FACTORS IX, X, AND PROTHROMBIN. PROTEIN C DOWNREGULATES THE INTRINSIC COAGULATION PATHWAY BY INACTIVATING FACTORS VAAND VIIIA. FACTORS IX, X, AND PROTEIN C ARE HIGHLY HOMOLOGOUS PROTEINS. EACH CONTAINS TWO EGF-HOMOLOGOUS DOMAINS AND A N-TERMINAL DOMAIN BEARING MULTIPLE -CARBOXYGLUTAMIC ACID RESIDUES, THE SO-CALLED GLA DOMAIN. COMPETITIVE BINDING EXPERIMENTS HAVE ESTABLISHED THAT FACTORS IX AND X BIND TO RECEPTORS ON ACTIVATED ENDOTHELIAL CELLS THROUGH INTERACTIONS OF THE EGF AND GLA DOMAINS, A PHYSIOLOGICAL MECHANISM FOR DIRECTING COAGULATION TO REGIONS OF DAMAGED ENDOTHELIUM. THE OBJECTIVE IS TO IMPROVE RECOMBINANT PROTEIN C FOR USE ASA SAFE ANTICOAGULANT/ANTITHROMBOTIC AGENT FOR SUPPRESSION OF CLOTTING IN A NUMBER OF VENOUS THROMBOTIC CONDITIONS. SPECIFICALLY, A PROTEIN C VARIANT WITH A HIGH BINDING AFFINITY FOR DAMAGED ENDOTHELIUM WILL BE DESIGNED. THE EGF-HOMOLOGOUS DOMAINS OF ...
https://www.sbir.gov/sbirsearch/detail/197248
1hcg - Proteopedia, life in 3D1hcg - Proteopedia, life in 3D
The structure of a large molecular fragment of factor Xa that lacks only a Gla (gamma-carboxyglutamic acid) domain (N-terminal 45 residues) has been solved by X-ray crystallography and refined at 2.2 A resolution to a crystallographic R-value of 0.168. The fragment identity was clearly established by automated Edman degradation. X-ray structure analysis confirmed the biochemical characterization and also revealed that the N-terminal epidermal growth factor (EGF)-like domain is flexibly disordered in crystals. The second EGF module, however, is positionally ordered making contacts with the catalytic domain. The overall folding of the catalytic domain is similar to that of alpha-thrombin, excluding the insertion loops of the latter with respect to simpler serine proteinases. The C-terminal arginine of the A-chain interacts in a substrate-like manner with the S1 specificity site of the active site of a crystallographically neighboring molecule. Based on this interaction and the structure of ...
http://proteopedia.org/wiki/index.php/1hcg
GAS6 | Bioanalytical Lab & Top CRO for Large Molecule BioanalysisGAS6 | Bioanalytical Lab & Top CRO for Large Molecule Bioanalysis
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. ...
https://www.bioagilytix.com/biomarkers/gas6/
Dissolved Organic Phosphorus (DOP):an indicator of organic matter turn-over? - ePICDissolved Organic Phosphorus (DOP):an indicator of organic matter turn-over? - ePIC
van Beusekom, J. and Jonge, V. N. (2010): Dissolved Organic Phosphorus (DOP):an indicator of organic matter turn-over? , The Wadden Sea:Changes and Challenges in a World Heritage Site. SyltMai 2010 ...
http://epic.awi.de/23711/
PMF1-BGLAP (1-211, His-tag) - AR51237PU-N | acris-antibodies.com
PMF1-BGLAP, 0.5 mg. This locus represents naturally occurring read-through transcription between the neighboring PMF1 (polyamine-modulated factor 1) and BGLAP (bone gamma-carboxyglutamate Gla protein) genes on chromosome 1.
https://www.acris-antibodies.com/proteins-growth-factors/pmf1-bglap-ar51237pu-n.htm
Download At The Center Of The Storm: My Years At The Cia 2007
gamma-carboxylated download At the Center of the Storm: My binds called by the proteins for other receptors; fragments viral as the rafts, the protaglandins or the variations. ligases signal Organic Common and FGFR1 salts, and are not secreted as proteins. Their colorectal B-cell is the TGFB-induced tail of a heavy insulator.
http://erik-mill.de/books/download-At-the-Center-of-the-Storm%3A-My-Years-at-the-CIA-2007.php
ADGRE3 overexpression lysate - LY410027 | acris-antibodies.com
ADGRE3 overexpression lysate, 0.1 mg. Transient overexpression lysate of egf-like module containing, mucin-like, hormone receptor-like 3 (EMR3)
https://www.acris-antibodies.com/lysates/adgre3-overexpression-lysate-ly410027.htm
The dichotomy in the effects of 1,25 dihydroxyvitamin D<sub>3</sub> and 24,25-dihydroxyvitamin D<sub>3</sub> on bone γ...
TY - JOUR. T1 - The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on bone γ-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats. AU - Wientroub, Shlomo. AU - Price, Paul A.. AU - Reddi, A Hari. PY - 1987/5. Y1 - 1987/5. N2 - Vitamin D-deficient, second generation, rachitic rats showed significant decrease in bone Gla protein (BGP) levels in circulation and in the skeleton. 1,25 dehydroxyvitamin D3 (1,25 (OH)2D3) exhibited the most potent influence on serum BGP levels in a dose-dependent manner. At a dose 25 ng/100 g body weight 1,25 (OH)2D3 showed a cumulative effect, i.e., the longer the treatment, the more circulating BGP was detected 24,25 dehydroxyvitamin D3 (24,25(OH)2D3) at the same doses did not show similar effect on the serum BGP levels, regardless of the serum calcium levels. Bone BGP levels assayed at various sites representing endochondral and intramenbranous ossification demonstrated an opposite pattern. ...
https://ucdavis.pure.elsevier.com/en/publications/the-dichotomy-in-the-effects-of-125-dihydroxyvitamin-dsub3sub-and
PHYTONADIONE INJECTABLEEMULSION, USP - Drug label and information - Rx Drugs Info
Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X). The prothrombin test is sensitive to the levels of three of these four factors-II, VII, and X. Vitamin K is an essential cofactor for a microsomal enzyme that catalyzes the post-translational carboxylation of multiple, specific, peptide-bound glutamic acid residues in inactive hepatic precursors of factors II, VII, IX, and X. The resulting gamma-carboxyglutamic acid residues convert the precursors into active coagulation factors that are subsequently secreted by liver cells into the blood.. Phytonadione is readily absorbed following intramuscular administration. After absorption, phytonadione is initially concentrated in the liver, but the ...
http://rxdrugsinfo.com/drug-info-label/phytonadione
China Organic Phosphorus Nitrogen Potassium Fertilizer Suppliers & Manufacturers - Buy Good Price Organic Phosphorus Nitrogen...
As one of the leading organic phosphorus nitrogen potassium fertilizer manufacturers and suppliers in China, we are featured by nutritious contents and effective function of our products. We have registered the export certification from AQSIQ. Be free to buy quality organic phosphorus nitrogen potassium fertilizer at competitive price from our factory.
http://m.sdjuci.com/corn-steep-liquor-powder/corn-steep-liquor-powder-for-fertilizer/organic-phosphorus-nitrogen-potassium.html
Natural Human Prothrombin protein (ab62502) | AbcamNatural Human Prothrombin protein (ab62502) | Abcam
Buy our Natural Human Prothrombin protein. Ab62502 is a protein fragment produced in Nativesyntheticaly and has been validated in FuncS, SDS-PAGE. Abcam…
http://www.abcam.com/natural-human-prothrombin-protein-ab62502.html
Models for protein binding to calcium oxalate surfaces<...
TY - JOUR. T1 - Models for protein binding to calcium oxalate surfaces. AU - Gul, Asiya. AU - Rez, Peter. PY - 2007/4. Y1 - 2007/4. N2 - It is widely believed that proteins rich in Asp, Glu or Gla (γ carboxyglutamic acid) interact strongly with calcium oxalate surfaces and inhibit calcium oxalate crystal growth. An alternative hypothesis would be that the interaction of Asp, Glu and Gla residues with surfaces could facilitate nucleation and crystal aggregation. Prothrombin fragment 1 and bikunin have been studied extensively as inhibitors, β-microglobulin, transferrin and antitrypsin have been found in stone matrix and tubulin has been observed in the attachment of crystals to cell surfaces. The aim of this study is to examine how well carboxylate groups in proteins found either in stone matrix, or proposed as inhibitors, could fit with the calcium ion sub-lattice of both calcium oxalate monohydrate and dihydrate surfaces. The carboxylate groups in the acidic Asp, Glu and Gla residues were ...
https://asu.pure.elsevier.com/en/publications/models-for-protein-binding-to-calcium-oxalate-surfaces
Blood Coagulation Proteins - Weight Loss - Barnard Health CareBlood Coagulation Proteins - Weight Loss - Barnard Health Care
endoplasmic reticulum sites of Gla protein synthesis. In the case of the blood coagulation proteins, the sole site of synthesis is the liver. Each carboxylated protein has a C-terminal propeptide sequence that binds the carboxylase enzyme, and directs a coordinated series of carboxylations of the recipient gluta-myl residues, before the propeptide is removed and the fully carboxylated protein is then secreted into the extracellular space for transport into the plasma.. Vitamin K acts as the essential recycling cofactor (or cosubstrate) for all protein carboxylation, Gla-forming reactions (Figure 3). In its dihydro or quinol form, the vitamin reacts with molecular oxygen, thereby creating a highly reactive, high-energy carba-nion at the Glu site for insertion of carbon dioxide, creating a new Gla residue. This vitamin K quinol oxidation step provides the essential energy for the endothermic carboxylation step. The other product of the reaction is the epoxide of vitamin K, comprising a ...
https://www.barnardhealth.us/weight-loss/blood-coagulation-proteins.html
Publicações | - CCMARPublicações | - CCMAR
Viegas CSB, Simes DC, Laizé V, Williamson MK, Price PA, M. Cancela L. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem. 2008;283(52):36655-64. doi:10.1074/jbc.M802761200 ...
https://ccmar.ualg.pt/biblio2?f%5Bauthor%5D=1038&s=type&o=asc
EMR2 Pre-design Chimera RNAi - (H00030817-R02) - Products - Abnova
Homo sapiens egf-like module containing, mucin-like, hormone receptor-like 2 (EMR2), transcript variant 2, mRNA. (H00030817-R02) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00030817-R02
EPO - T 0339/98 (Vitamin K-dependent proteins/ELI LILLY) of 18.9.2001EPO - T 0339/98 (Vitamin K-dependent proteins/ELI LILLY) of 18.9.2001
Summary of Facts and Submissions. I. The patent proprietors lodged an appeal against the interlocutory decision of the opposition division issued 4 February 1998 whereby the European patent No. 0. 363 126 with title Method for the purification of vitamin K-dependent proteins, which had been opposed by one party on grounds of Article 100(a) EPC (lack of novelty and lack of inventive step), was maintained in amended form on the basis of the auxiliary request then on file. Claim 1 therein read as follows:. A method for recovering and purifying vitamin K-dependent proteins from a cell culture medium of cells which produce vitamin K-dependent proteins, said medium containing forms of the desired vitamin K-dependent protein that differ in -carboxyglutamate content and therefore in specific activity, said method comprising:. a. removing divalent cations from the medium;. b. contacting the medium with a protein-binding ion-exchange resin under conditions such that the protein is bound to the ...
https://www.epo.org/law-practice/case-law-appeals/recent/t980339eu1.html
United States Human Prothrombin Complex Market Report 2016United States Human Prothrombin Complex Market Report 2016
Sales, means the sales volume of Human Prothrombin Complex Revenue, means the sales value of Human Prothrombin Complex This report studies sales (consumption) of Human Prothrombin Complex in United States market, focuses on the top players, with sales, price, revenue and market share for each player, covering Baxter CSL Bayer Grifols Octapharma Shanghai RAAS Hualan Bio
https://www.researchmoz.us/united-states-human-prothrombin-complex-market-report-2016-report.html
Prothrombin (474-477) [Mus musculus]|Role in coagulation cascadeProthrombin (474-477) [Mus musculus]|Role in coagulation cascade
|p||strong|Prothrombin|/strong| (coagulation factor II) (H2N-Tyr-Ile-His-Pro-OH) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic aci
http://www.apexbt.com/coagulation-factor-ii-peptide-prothrombin-474-477-mus-musculus.html
Natural Human Protein C (ab62448) | AbcamNatural Human Protein C (ab62448) | Abcam
Buy our Natural Human Protein C. Ab62448 is a full length protein produced in Nativesyntheticaly and has been validated in FuncS, SDS-PAGE. Abcam provides free…
http://www.abcam.com/natural-human-protein-c-ab62448.html
Carboxylated vs. non-carboxylated?Carboxylated vs. non-carboxylated?
When asking the question of carboxylated vs. non-carboxylated, the answer comes down to an adhesion coating controlled by carboxylation.
https://www.mcpolymers.com/library/carboxylated-vs.-non-carboxylated
Staphylocoagulase-binding region in human prothrombin<...
TY - JOUR. T1 - Staphylocoagulase-binding region in human prothrombin. AU - Kawabata, Shun-Ichiro. AU - Morita, Takashi. AU - Iwanaga, Sadaaki. AU - Igarashi, Hideo. PY - 1985/1/1. Y1 - 1985/1/1. N2 - A staphylocoagulase-binding region in human prothrombin was studied by utilizing several fragments prepared from prothrombin by limited proteolysis. Bovine prothrombin, prethrombin 1, prethrombin 2, and human diisopropylphosphorylated α-thrombin strongly inhibited formation of the complex (staphylothrombin) between human prothrombin and staphylocoagulase, but bovine prothrombin fragment 1 and fragment 2 had no effect on the complex formation, indicating that the binding region of human prothrombin for staphylocoagulase is located in the prethrombin 2 molecule. To identify further the staphylocoagulase-binding region, human α-thrombin was cleaved into the NH2-terminal large fragment (Mr = 26, 000) and the COOH-terminal fragment (Mr = 16,000) by porcine pancreatic elastase. Of these fragments, ...
https://kyushu-u.pure.elsevier.com/en/publications/staphylocoagulase-binding-region-in-human-prothrombin
Global Organic Phosphorus Flame Retardant Sales Market Report 2016 : ReportsnReports
[127 Pages Report] Check for Discount on Global Organic Phosphorus Flame Retardant Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Organic Phosphorus Flame...
http://www.reportsnreports.com/reports/675984-global-organic-phosphorus-flame-retardant-sales-market-report-2016.html
Search Results for suppressor of cytokine signaling | joeSearch Results for suppressor of cytokine signaling | joe
EMR1 2015 207111_at −2.0 0.185 EGF-like module containing, mucin-like, hormone receptor-like 1 SOCS3 9021 227697_at −1.9 0.198 Suppressor of cytokine signalling 3 LRP12 29 967 220254_at −1.9 0.143 Low density lipoprotein-related protein 12 RGS17. ...
https://joe.bioscientifica.com/search?access_0=all&page=7&pageSize=10&q=%22suppressor+of+cytokine+signaling%22&sort=relevance
Proc - Vitamin K-dependent protein C precursor - Mus musculus (Mouse) - Proc gene & proteinProc - Vitamin K-dependent protein C precursor - Mus musculus (Mouse) - Proc gene & protein
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
http://www.uniprot.org/uniprot/P33587
Organic Eprints - Phosphorus in the coarse soil fraction is related to soil organic phosphorus mineralization measured by...Organic Eprints - Phosphorus in the coarse soil fraction is related to soil organic phosphorus mineralization measured by...
A sound prediction of soil organic phosphorus (Po) mineralization would be helpful to improve fertilizer recommendations. However, in most mineral soils expensive and time consuming isotopic dilution experiments are required to assess Po mineralization. A proposed method to estimate Po mineralization is the quantification of P in the coarse fraction (CF, ,53 μm) of the soil. The aim of this study was to evaluate if P in the CF can effectively predict Po mineralization. Soil samples from three North American long-term arable field experiments (,10 years) with different textures (sand content 15-82%) and different fertilization treatments (non-P-fertilized, mineral P fertilizer, poultry litter) were analyzed. Soil samples were physically fractioned into CF and fine fraction (FF, ,53 μm). Total P (Pt), Po, and total carbon (Ct) were determined in each fraction. Gross and net Po mineralization rates as well as soil respiration were determined in a 13-day-incubation experiment. The cumulative gross ...
http://orgprints.org/32310/
Using organic phosphorus to sustain pasture productivity: A perspectiveUsing organic phosphorus to sustain pasture productivity: A perspective
Organic phosphorus (P) in grazed pastures/grasslands could sustain production systems that historically relied on inorganic P fertiliser. Interactions between inorganic P, plants and soils have been studied extensively. However, less is known about the transformation of organic P to inorganic orthophosphate. This paper investigates what is known about organic P in pasture/grassland soils used for agriculture, as well as the research needed to utilise organic P for sustainable plant production. Organic P comprises , 50% of total soil P in agricultural systems depending on location, soil type and land use. Organic P hydrolysis and release of orthophosphate by phosphatase enzymatic activity is affected by a range of factors including: (a) the chemical nature of the organic P and its ability to interact with the soil matrix; (b) microorganisms that facilitate mineralisation; (c) soil mineralogy; (d) soil water electrolytes; and (e) soil physicochemical properties. Current biogeochemical ...
http://researcharchive.lincoln.ac.nz/handle/10182/8749
organic phosphorus
So youve been avoiding dark colas to help manage your serum phosphorus level. Yet, you are still struggling to keep it in goal range. Well,…. Continue Reading » ...
https://blogs.davita.com/kidney-diet-tips/tag/organic-phosphorus/
CONANTOKIN (PS60025) | InterPro | EMBL-EBICONANTOKIN (PS60025) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
http://www.ebi.ac.uk/interpro/signature/PS60025
Gentaur Molecular :Assaypro \ Factor IX, anti human \ 12222-05011Gentaur Molecular :Assaypro \ Factor IX, anti human \ 12222-05011
Gentaur molecular products has all kinds of products like :search , Assaypro \ Factor IX, anti_human \ 12222-05011 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=66123&supplier=search&name=Factor%20IX,%20anti_human
Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating...Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating...
TY - JOUR. T1 - Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor. AU - Tormoen, Garth W.. AU - Khader, Ayesha. AU - Gruber, András. AU - McCarty, Owen J.T.. PY - 2013/6/1. Y1 - 2013/6/1. N2 - Thrombosis significantly contributes to cancer morbidity and mortality. The mechanism behind thrombosis in cancer may be circulating tissue factor (TF), as levels of circulating TF are associated with thrombosis. However, circulating TF antigen level alone has failed to predict thrombosis in patients with cancer. We hypothesize that coagulation factor levels regulate the kinetics of circulating TF-induced thrombosis. Coagulation kinetics were measured as a function of individual coagulation factor levels and TF particle concentration. Clotting times increased when pooled plasma was mixed at or above a ratio of 4:6 with PBS. Clotting times increased when pooled plasma was mixed at or above a ratio of 8:2 with factor ...
https://ohsu.pure.elsevier.com/en/publications/physiological-levels-of-blood-coagulation-factors-ix-and-x-contro-2
Anticoagulant-Related Nephropathy | JACC: Journal of the American College of CardiologyAnticoagulant-Related Nephropathy | JACC: Journal of the American College of Cardiology
We congratulate Bohm et al. (1) for their interesting study regarding the effects of warfarin or dabigatran etexilate (DE) on renal function in the patients with atrial fibrillation (AF) receiving oral anticoagulation, showing a decline in renal function that was greater in those taking warfarin compared with DE, which was amplified by diabetes and previous vitamin K antagonist use. The authors propose this adverse renal outcome may be due to inhibition by warfarin of vitamin K-dependent matrix gamma-carboxyglutamic acid (Gla/MPG) and resulting in renal vascular calcification and arterial damage.. Recent data showed that excessive anticoagulation with warfarin can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients, especially in those with chronic kidney disease (CKD), which was described as warfarin-related nephropathy (WRN) (2). Brodsky et al. (3) was the first to describe this entity through kidney ...
http://www.onlinejacc.org/content/66/23/2681
Human Factor X - Creative EnzymesHuman Factor X - Creative Enzymes
Factor X is a vitamin K-dependent protein zymogen which is synthesized in the liver and circulates in plasma as a two chain molecule linked by a disulfide bond. Prior to
https://www.creative-enzymes.com/product/Human-Factor-X_4241.html
Collaborative Research: Dissolved Organic Phosphorus Controls on Marine Nitrogen Fixation and Export ProductionCollaborative Research: Dissolved Organic Phosphorus Controls on Marine Nitrogen Fixation and Export Production
A public searchable database of research at the University of New Hampshire. Search UNH faculty profiles, publications, grants, teaching activities.
https://findscholars.unh.edu/display/grant415776
Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study | cardiohub
Vitamin K-dependent proteins, including matrix Gla-protein, have been shown to inhibit vascular calcification. Activation of these proteins via carboxylation...
http://blog.clougle.com/dietary-intake-of-menaquinone-is-associated-with-a-reduced-r
Sheep Anti Human Factor IX Polyclonal Fractionated - Innovative ResearchSheep Anti Human Factor IX Polyclonal Fractionated - Innovative Research
Sheep Anti Human Factor IX Polyclonal Fractionated from Innovative Research is a polyclonal antibody in a Frozen liquid format. This antibody has been purified using protein G affinity chromatography . Fractionated preparations may be especially useful in research where high affinity is necessary, especially in cases w
https://www.innov-research.com/products/sheep-anti-human-factor-ix-polyclonal-fractionated
Matrix Gla Protein (MGP) ELISA KitsMatrix Gla Protein (MGP) ELISA Kits
Reactivity: Chicken, Cow, Dog and more. Compare 50 different MGP ELISA Kits & buy the right one directly at antibodies-online.com!
https://www.antibodies-online.com/abstract/Matrix+Gla+Protein+
Managing Geese | Lake County, ILManaging Geese | Lake County, IL
Goose feces are high in organic phosphorus, which can contribute to excessive algae growth in lakes. Increased development in Lake County has inadvertently created ideal habitat for goose populations.
http://lakecountyil.gov/2425/Managing-Geese
Serviced Apartments Istria: Find Cheap Self Contained Accommodation Istria | ExpediaServiced Apartments Istria: Find Cheap Self Contained Accommodation Istria | Expedia
Find best apartment hotels in Istria with Expedia. Short and long stay self contained accommodation with kitchen, wifi and parking. Book & earn Expedia+ points now!
https://www.expedia.co.nz/Istria-Hotels-Apartment-Hotel.0-0-d6047237-tApartmentHotel.Travel-Guide-Filter-Hotels
Platelet factor 4 impairs the anticoagulant activity of activated protein C.
Platelet factor 4 (PF4) is an abundant platelet alpha-granule chemokine released following platelet activation. PF4 interacts with thrombomodulin and the gamma-carboxyglutamic acid (Gla) domain of protein C, thereby enhancing activated protein C (APC) generation by the thrombin-thrombomodulin complex. However, the protein C Gla domain not only mediates protein C activation in vivo, but also plays a critical role in modulating the diverse functional properties of APC once generated. In this study we demonstrate that PF4 significantly inhibits APC anti-coagulant activity. PF4 inhibited both protein S-dependent APC anticoagulant function in plasma and protein S-dependent factor Va (FVa) proteolysis 3- to 5-fold, demonstrating that PF4 impairs protein S cofactor enhancement of APC anticoagulant function. Using recombinant factor Va variants FVa-R506Q/R679Q and FVa-R306Q/R679Q, PF4 was shown to impair APC proteolysis of FVa at position Arg(306) by 3-fold both in the presence and absence of protein S. ...
https://www.lenus.ie/handle/10147/207829
Tom Prophet Hsiung » FIX
The Soluble Cofactors Protein S and Von Willebrand Factor. Protein S. Protein S is a vitamin K-dependent single-chain GP of 635 amino acids that circulates with a plasma half-life of 42 hours. Part of the total protein S pool circulates in a free form at a concentration of 150 nM, whereas the majority (~60%; 200 nM) circulates bound to the complement regulatory protein C4b-binding protein (C4BP). Protein S is primarily synthesized in the liver by hepatocytes, in addition to endothelial cells, megakaryocytes, testicular Leydig cells, and osteoblasts.. The protein structure of protein S differs from the other vitamin K-dependent proteins as it lacks a serine protease domain and, consequently, is not capable of catalytic activity. Protein S is composed of a Gla domain comprising 11 Gla residues, a thrombin-sensitive region (TSR), four EGF domains, and a C-terminal sex hormone-binding globulin (SHBG)-like region that consists of two laminin G-type domains. The SHBG-like domain is involved in the ...
http://www.tomhsiung.com/wordpress/tag/fix/
Activation of recombinant human protein C<...
TY - JOUR. T1 - Activation of recombinant human protein C. AU - Lee, Timothy K.. AU - Bangalore, Neelesh. AU - Velander, William. AU - Drohan, William N.. AU - Lubon, Henryk. PY - 1996/5/1. Y1 - 1996/5/1. N2 - We have produced recombinant human Protein C (rHPC) in the milk of transgenic swine. After purification, we have analyzed the interaction of the zymogen with Protac, thrombin/thrombomodulin and thrombin alone. The amidolytic and anticoagulant activities of rAPC after Protac activation were ~80% those of its human plasma counterpart. Upon the excision of the activation peptide by thrombin/thrombomodulin complex, both the natural and recombinant activation products had similar enzymatic and biological activities. This. observation can be attributed to the difference in the mechanism of action between the two activators and structural differences between HPC and rHPC.. AB - We have produced recombinant human Protein C (rHPC) in the milk of transgenic swine. After purification, we have ...
https://nebraska.pure.elsevier.com/en/publications/activation-of-recombinant-human-protein-c
BGD - Leaching of inorganic and organic phosphorus and nitrogen in contrasting beech forest soils - seasonal patterns and...BGD - Leaching of inorganic and organic phosphorus and nitrogen in contrasting beech forest soils - seasonal patterns and...
The Ms of Fetzer et al. entitled Leaching of inorganic and organic phosphorus and nitrogen in contrasting beech forest soils - seasonal patterns and effects of fertilization quantifies annual organic and inorganic P and N fluxes from organic layers and from the mineral topsoil. For this purpose, zero-tension-lysimeters were used in the three soil horizons that were artificially irrigated to standardize water flow. The authors established a comparative study; two sites under beech with different phosphorous availability and sorption capacity (sandy soil and a soil on basalt) were selcted, and both sites were subjected to a full factorial N×P fertilization experiment. During the 18-months monitoring period, the sites were samples five times.. In the context of increasing nutrient imbalances in trees and the occurrence of more frequent and intense climate extremes, the topic of this manuscript is of great importance to both science and practice. The experimental design is state of the art. I ...
https://bg.copernicus.org/preprints/bg-2021-188/
New Page 1
A vitamin K-dependent carboxylation converts glutamate residues on prothrombin, which are weak chelators of Ca2+, into gamma-carboxyglutamate, a much stronger chelator. The binding of Ca2+ by prothrombin anchors it to the phospholipid membranes derived from blood platlets following injury. This binding of prothrombin brings it into close contact with two enzymes which regulate its conversion into thrombin, which can then activate fibrinogen in the plasma to fill the breach.. Sources:. Vitamin K is found in green leafy vegetables.. Fascinating Fact: To prevent excessive clotting after an operation the vitamin K antagonist, Warfarin (rat poison) is administered in carefully controlled doses.. ...
http://www.chm.bris.ac.uk/webprojects2001/grassby/vitamink.htm
Osteocalcin Antibody | Osteocalcin Immunohistochemistry | Monoclonal Anti-Bovine Osteocalcin (Clone OC4-30, Clone OCG2, Clone...Osteocalcin Antibody | Osteocalcin Immunohistochemistry | Monoclonal Anti-Bovine Osteocalcin (Clone OC4-30, Clone OCG2, Clone...
Monoclonal Anti-Bovine Osteocalcin Antibody (Clones OC4-30,OCG2, OCG3 and OCG4) is raised against bovine osteocalcin and recognizes both bovine and human osteocalcins. Clone OC4-30 is specific for position 17 gamma-carboxylated osteocalcin and does not recognize decarboxylated osteocalcin. Osteocalcin epitopes used to generate Clones OCG2, OCG3 and OCG4 are amino acids 45-49, amino acids 21-31 and amino acids 4-9, respectively. This collection of osteocalcin antibody clones facilitates osteocalcin immunohistochemistry studies which can also be performed on paraffin-embedded tissues (as described in the Resources). In addition to cross-reactivity with bovine and human osteocalcin, clones OCG4-30, OCG3 and OCG4 are also capable of recognizing osteocalcin in several other species as listed. For species-specific osteocalcin detection, Takara Bio offers additional osteocalcin antibody products. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Bone_Research/Osteocalcin_Bovine?sitex=10020:22372:US&PEBCL1=HB79mxfeEjjDeOBbHA8vOslWsb&PEBCL1_pses=ZGC4D09D9DFAFB4FC181BB5C1D3C2BBCB43778C59F23CE6C9A382BA305C6D7AB7F02A13B52F6F8C54845DA234ED2943AB8120D2BAAF4D2E1D7
Osteocalcin Antibody | Osteocalcin Immunohistochemistry | Monoclonal Anti-Bovine Osteocalcin (Clone OC4-30, Clone OCG2, Clone...Osteocalcin Antibody | Osteocalcin Immunohistochemistry | Monoclonal Anti-Bovine Osteocalcin (Clone OC4-30, Clone OCG2, Clone...
Monoclonal Anti-Bovine Osteocalcin Antibody (Clones OC4-30,OCG2, OCG3 and OCG4) is raised against bovine osteocalcin and recognizes both bovine and human osteocalcins. Clone OC4-30 is specific for position 17 gamma-carboxylated osteocalcin and does not recognize decarboxylated osteocalcin. Osteocalcin epitopes used to generate Clones OCG2, OCG3 and OCG4 are amino acids 45-49, amino acids 21-31 and amino acids 4-9, respectively. This collection of osteocalcin antibody clones facilitates osteocalcin immunohistochemistry studies which can also be performed on paraffin-embedded tissues (as described in the Resources). In addition to cross-reactivity with bovine and human osteocalcin, clones OCG4-30, OCG3 and OCG4 are also capable of recognizing osteocalcin in several other species as listed. For species-specific osteocalcin detection, Takara Bio offers additional osteocalcin antibody products. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Bone_Research/Osteocalcin_Bovine?sitex=10020:22372:US&PEBCL1=w0Xk9kvAEHxj5N002gMbchJqiY&PEBCL1_pses=ZG88E18E8D3CAC9C55454B1CC5B8CD76686567E100BF4E457051427071ADEF48B32AF9E7793EB7ECEAB15B200404BFA19CD6343A9B87773814
Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: preferential protein accumulation in skeletal...Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: preferential protein accumulation in skeletal...
Matrix Gla protein (MGP) belongs to the family of vitamin K dependent, Gla containing proteins and, in mammals, birds and Xenopus, its mRNA has been previously detected in bone, cartilage and soft...
https://link.springer.com/article/10.1007%2Fs00418-005-0125-6
Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. - Full Text View - ClinicalTrials.govAdministration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. - Full Text View - ClinicalTrials.gov
Sixty septic patients with plasma protein C activity , 60 % will be enrolled in the study. Patients will be randomly allocated to be treated with either a) a continuous infusion of human Protein C concentrate at 3 UI/Kg/hr for 72 hours to reach plasma protein C activity between 70 and 120 % b)to a continuous infusion of activated protein C at 24 micrograms/Kg/hr for 96 hours, c) a standard teatment(control; each n = 20). In all groups, norepinephrine will be titrated to achieve a mean arterial pressure (MAP) between 65 and 75 mmHg. Data from right heart catheterization, from microcirculation (SDF imaging) and from organ function as well as norepinephrine requirements will be obtained at baseline and after 24, 48, 72 hours ...
https://clinicaltrials.gov/ct2/show/NCT01411670
Quantification of soil organic phosphorus and low-molecular-weight organic acids by ion chromatography | Soil Phosphorus ForumQuantification of soil organic phosphorus and low-molecular-weight organic acids by ion chromatography | Soil Phosphorus Forum
A new chromatographic method developed by Waithaisong et al. (2015) was shown to suitable for the quantification of organic P and LMWOAs in soil samples. This paper was sent to me as part of a personal e-mail response from Dr. Claude Plassard to the previous post asking help on HPLC-Po method. Daniel Blackburn
https://soilpforum.com/2015/01/26/220/
IV. Organic Phosphorus in Soil Solution - Tài liệu text
... P WARKENTIN ADVANCES IN AGRONOMY Prepared under the Auspices of the AMERICAN SOCIETY OF AGRONOMY VOLUME 29 Edited by N C BRADY International Rice Research Institute Manila, Philippines ADVISORY... importance in the infection process of plant roots by N2
https://toc.123doc.net/document/2792109-iv-organic-phosphorus-in-soil-solution.htm
Haematological · Part One
Prevents the return of vitamin K to its reduced form, and therefore the gamma-carboxylation of vitamin-K dependent clotting factors (II, VII, IX, X), as well as Protein C and Protein S ...
http://www.partone.lifeinthefastlane.com/anticoagulants.html
ConantokinConantokin
Rigby AC, Baleja JD, Li L, Pedersen LG, Furie BC, Furie B (December 1997). "Role of gamma-carboxyglutamic acid in the calcium- ... It differs from Con-R mainly in the C-terminal amino acids and, like Con-R, it induces sleep-like symptoms in young mice, with ... a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor". Neuroscience Letters. 118 (2): 241-4. doi:10.1016/ ... 101 (1-2): 109-16. doi:10.1016/S0304-3959(02)00303-2. PMID 12507705. S2CID 25950992. Jimenez EC, Donevan S, Walker C, Zhou LM, ...
https://en.wikipedia.org/wiki/Conantokin
EGF-like domainEGF-like domain
In factors VII, IX and X, the two cbEGF modules are preceded by an N-terminal gamma-carboxyglutamic acid (Gla) containing ... It comprises about 30 to 40 amino-acid residues and has been found in a large number of mostly animal proteins. Most ... β-Hydroxylation appears in hEGF- and cEGF-like domains, the former is hydroxylated on an aspartic acid while the latter is ... Multiple cbEGF domains are often connected by one or two amino acids to form larger, repetitive arrays, here referred to as ' ...
https://en.wikipedia.org/wiki/EGF-like_domain
Factor IXFactor IX
Freedman SJ, Furie BC, Furie B, Baleja JD (Sep 1995). "Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich ... Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the ... 14 Suppl 1: S59-64. doi:10.1097/00001721-200306001-00014. PMID 14567539. Du X (May 2007). "Signaling and regulation of the ... 9 (1): 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097. Kurachi K, Davie EW (Nov ...
https://en.wikipedia.org/wiki/Factor_IX
ThrombinThrombin
Deficiency of vitamin K or administration of the anticoagulant warfarin inhibits the production of gamma-carboxyglutamic acid ... vitamin K-dependent reaction that converts 10-12 glutamic acids in the N terminus of the molecule to gamma-carboxyglutamic acid ... 32 Suppl 1: 3-15. doi:10.1055/s-2006-939550. PMID 16673262. Huber R, Bode W (1978-03-01). "Structural basis of the activation ... 209 (1): 68-74. doi:10.1016/j.jamcollsurg.2009.03.016. PMID 19651065. Greenhalgh DG, Gamelli RL, Collins J, Sood R, Mozingo DW ...
https://en.wikipedia.org/wiki/Thrombin
Fetuin-BFetuin-B
2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured ... 48 (1): 106-13. doi:10.1053/j.ajkd.2006.03.083. PMID 16797392. v t e (CS1: long volume value, Genes on human chromosome 3, All ... J. 376 (Pt 1): 135-45. doi:10.1042/BJ20030676. PMC 1223762. PMID 12943536. Wajih N, Borras T, Xue W, et al. ( ... "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1". Glycoconj. J. 9 (6): 315 ...
https://en.wikipedia.org/wiki/Fetuin-B
List of MeSH codes (D12.125)List of MeSH codes (D12.125)
2-aminoadipic acid MeSH D12.125.119.170 - aspartic acid MeSH D12.125.119.170.150 - d-aspartic acid MeSH D12.125.119.170.275 - ... aspartic acid MeSH D12.125.067.500.150 - d-aspartic acid MeSH D12.125.067.500.275 - isoaspartic acid MeSH D12.125.067.500.400 ... aspartic acid MeSH D12.125.427.300 - glutamic acid MeSH D12.125.481.100 - allylglycine MeSH D12.125.481.700 - n-substituted ... imino acids MeSH D12.125.072.401.200 - azetidinecarboxylic acid MeSH D12.125.072.401.623 - proline MeSH D12.125.072.401.623.270 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.125)
List of MeSH codes (D02)List of MeSH codes (D02)
... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ... muramic acids MeSH D02.241.081.844.562 - neuraminic acids MeSH D02.241.081.844.562.668 - sialic acids MeSH D02.241.081.844. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
Vitamin K antagonistVitamin K antagonist
Synthesis Of Y-Carboxyglutamic Acid". Critical Reviews in Biochemistry. 8 (2): 191-223. doi:10.3109/10409238009105469. PMID ... For example, it is needed to carboxylate specific glutamic acid residues on prothrombin. Without these residues carboxylated, ... Warfarin (Coumadin) Coumatetralyl Phenprocoumon Acenocoumarol Dicoumarol Tioclomarol Brodifacoum Another group of VKAs are 1,3- ...
https://en.wikipedia.org/wiki/Vitamin_K_antagonist
Carboxyglutamic acidCarboxyglutamic acid
... (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post- ... In the biosynthesis of γ-carboxyglutamic acid, the γ-proton on glutamic acid is abstracted, and CO2 is subsequently added. The ... γ-Carboxyglutamic acid residues play an important role in coagulation. The high-affinity calcium binding sites in the GLA ... Then CO2 is added to the γ-carbon to form γ-carboxyglutamic acid. Fig. 1.[permanent dead link] A number of γ-carboxyglutamate ...
https://en.wikipedia.org/wiki/Carboxyglutamic_acid
Non-proteinogenic amino acidsNon-proteinogenic amino acids
Carboxyglutamic acid. Whereas glutamic acid possess one γ-carboxyl group, Carboxyglutamic acid possess two. Hydroxyproline. ... ic acid.) Most natural amino acids are α-amino acids in the L conformation, but some exceptions exist. Some non-α-amino acids ... and a carboxylic acid (-COOH) functional group is an amino acid. The proteinogenic amino acids are small subset of this group ... amino acids. Other amino acids are solely found in abiotic mixes (e.g. α-methylnorvaline). Over 30 unnatural amino acids have ...
https://en.wikipedia.org/wiki/Non-proteinogenic_amino_acids
Peptidyl-glutamate 4-carboxylasePeptidyl-glutamate 4-carboxylase
Furie B, Bouchard BA, Furie BC (March 1999). "Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid". Blood. 93 (6): ... 2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing). This enzyme catalyses the following chemical reaction peptidyl-4- ...
https://en.wikipedia.org/wiki/Peptidyl-glutamate_4-carboxylase
Gla domainGla domain
Freedman SJ, Furie BC, Furie B, Baleja JD (1995). "Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding ... Kulman JD, Harris JE, Xie L, Davie EW (February 2001). "Identification of two novel transmembrane gamma-carboxyglutamic acid ... "Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins". Proc. Natl. Acad. Sci ... The GLA domain binds calcium ions by chelating them between two carboxylic acid residues. These residues are part of a region ...
https://en.wikipedia.org/wiki/Gla_domain
Protein CProtein C
Esmon NL, DeBault LE, Esmon CT (May 1983). "Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless ... 5) Multiple proteolytic cleavages of the polypeptide backbone to remove an 18 amino acid signal peptide, a 24 amino acid ... Inactive protein C comprises 419 amino acids in multiple domains:: 2383 one Gla domain (residues 43-88); a helical aromatic ... a 32 amino acid N-terminus signal peptide preceding a propeptide.: S11 Protein C is formed when a dipeptide of Lys198 and ...
https://en.wikipedia.org/wiki/Protein_C
1978 in science1978 in science
M. L. (1978). "Timed appearance of a calcium-binding protein containing gamma-carboxyglutamic acid in developing chick bone". ... 36 (1): 92-106. Bibcode:1978Icar...36...92F. doi:10.1016/0019-1035(78)90076-3. Rivest, R.; Shamir, A.; Adleman, L. (1978). "A ... November 1 - Helen Czerski, English physicist and science populariser. January 14 - Kurt Gödel (b. 1906), American ...
https://en.wikipedia.org/wiki/1978_in_science
Gamma-glutamyl carboxylaseGamma-glutamyl carboxylase
... while simultaneously adding CO2 to protein-bound glutamic acid (abbreviation = Glu) to form gamma-carboxyglutamic acid (also ... 54 (1): 459-77. doi:10.1146/annurev.bi.54.070185.002331. PMID 3896125. Presnell SR, Stafford DW (2002). "The vitamin K- ... 25 (1): 127-49. doi:10.1146/annurev.nutr.25.050304.092713. PMID 16011462. Zhang B, Ginsburg D (September 2004). "Familial ... ISBN 0-12-183492-1. glutamyl+carboxylase at the US National Library of Medicine Medical Subject Headings (MeSH) This article ...
https://en.wikipedia.org/wiki/Gamma-glutamyl_carboxylase
ProthrombinaseProthrombinase
The light chain contains an N-terminal γ-carboxyglutamic acid domain (Gla domain) and two epidermal growth factor-like domains ... In Factor V Leiden, a G1691A nucleotide replacement results in an R506Q amino acid mutation. Factor V Leiden increases the risk ... "Complete cDNA and derived amino acid sequence of human factor V". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4846-50. Bibcode: ... Meizothrombin contains fragment 1•2 A chain linked to the B chain by a disulfide bond. Subsequent cleavage of meizothrombin by ...
https://en.wikipedia.org/wiki/Prothrombinase
OsteocalcinOsteocalcin
... , also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) ... Hauschka PV, Reid ML (August 1978). "Timed appearance of a calcium-binding protein containing gamma-carboxyglutamic acid in ... 396 (1-2): 66-9. doi:10.1016/j.cca.2008.07.001. PMID 18657532. Ba Y, Huang H, Yang Y, Cui L, Zhu J, Zhu C, et al. (November ... 382 (1): 521-526. doi:10.1016/j.mce.2013.10.008. PMC 3850748. PMID 24145129. Obri A, Khrimian L, Karsenty G, Oury F (March 2018 ...
https://en.wikipedia.org/wiki/Osteocalcin
Vitamin K2Vitamin K2
... in conversion of peptide-bound glutamic acid (Glu) to γ-carboxy glutamic acid (Gla) in these proteins).[8] ... 1 (6): e000638. doi:10.3945/cdn.117.000638. PMC 5998353. PMID 29955705.. *^ a b c d e f g Rhéaume-Bleue, Kate (August 27, 2013 ... Many bacteria synthesize menaquinones from chorismic acid. They use it as a part of the electron transport chain, playing a ... Oxygen, heme, and menaquinones are needed for many species of lactic acid bacteria to conduct respiration.[32] ...
https://en.wikipedia.org/?curid=38233257
GAS6GAS6
... is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell ... It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene ... 30 (1): 129-31. doi:10.1006/geno.1995.0027. PMID 8595896. Li R, Chen J, Hammonds G, Phillips H, Armanini M, Wood P, Bunge R, ... 415 (1): 59-63. doi:10.1016/S0014-5793(97)01093-4. PMID 9326369. Nakano T, Ishimoto Y, Kishino J, Umeda M, Inoue K, Nagata K, ...
https://en.wikipedia.org/wiki/GAS6
Vitamin K2Vitamin K2
... in conversion of peptide-bound glutamic acid (Glu) to γ-carboxy glutamic acid (Gla) in these proteins). Carboxylation of these ... Oxygen, heme, and menaquinones are needed for many species of lactic acid bacteria to conduct respiration. Vitamin K Vitamin K1 ... Many bacteria synthesize menaquinones from chorismic acid. They use it as a part of the electron transport chain, playing a ... 1570 (1): 27-32. doi:10.1016/s0304-4165(02)00147-2. PMID 11960685. Hofbauer LC, Brueck CC, Shanahan CM, Schoppet M, Dobnig H ( ...
https://en.wikipedia.org/wiki/Vitamin_K2
SCOPe 2.08: Species: Pig (Sus scrofa) [TaxId: 9823]SCOPe 2.08: Species: Pig (Sus scrofa) [TaxId: 9823]
gamma-carboxy-glutamic acid-rich domain. *. Family g.32.1.1: GLA-domain [57631] (7 proteins). heterogeneous fold; applies to ... Nucleic Acids Research 42:D304-309. doi: 10.1093/nar/gkt1240. Chandonia JM, Guan L, Lin S, Yu C, Fox NK, Brenner SE. 2022. ... Nucleic Acids Research 50:D553-559. doi: 10.1093/nar/gkab1054. (citing information) Copyright © 1994-2022 The SCOP and SCOPe ... Timeline for Species Pig (Sus scrofa) [TaxId:9823] from g.32.1.1 Osteocalcin: *Species Pig (Sus scrofa) [TaxId:9823] from g. ...
https://scop.berkeley.edu/sunid=103596
Protein S deficiency: a clinical perspective - Blood ClotsProtein S deficiency: a clinical perspective - Blood Clots
GLA, γ-carboxyglutamic acid domain; AS, aromatic stack domain; TSR, thrombin sensitive region domain; EGF, epidermal growth ... A frequently encountered amino acid substitution is the PS Heerlen polymorphism, with a prevalence of 0.52% in the general ... and mature PS consists of 635 amino acids. Only recently, the PROS1 promoter has been characterized [19]. A minimal PROS1 ... 1. PROS1 messenger RNA (mRNA) (a) with corresponding protein S (PS) domains (b). (a) mRNA encoding protein S. Ex indicates exon ...
https://www.stoptheclot.org/news/article137/
DailyMed - WARFARIN SODIUM tabletDailyMed - WARFARIN SODIUM tablet
Vitamin K promotes the biosynthesis of γ-carboxyglutamic acid residues in the proteins that are essential for biological ... celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, ... Table 1: Three Ranges of Expected Maintenance Warfarin Sodium Tablets Daily Doses Based on CYP2C9 and VKORC1 Genotypes† VKORC1 ... The 1 mg also contains FD&C red no. 40. The 2 mg also contains FD&C blue no. 2 aluminum lake and FD&C red no. 40 aluminum lake ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0cbce382-9c88-4f58-ae0f-532a841e8f95
Osteocalcin Antibody (190125) (MAB1419): Novus BiologicalsOsteocalcin Antibody (190125) (MAB1419): Novus Biologicals
Osteocalcin, also known as Bone gamma -Carboxyglutamic Acid Protein, is a secreted protein whose expression is restricted to ...
https://www.novusbio.com/products/osteocalcin-antibody-190125_mab1419
WarfarinWarfarin
The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for ... The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for ... Fibric Acid Antabuse Uric Acid Selective Serotonin Reuptake Inhibitor Cor Pulmonale Fecal Occult Blood Migraine Headache ... Tranexamic Acid Transfusion Associated Circulatory Overload Transfusion Associated Graft Versus Host Disease Transfusion ...
https://fpnotebook.com/hemeonc/Pharm/Wrfrn.htm
Carla Alexandra São Bento Viegas | - CCMARCarla Alexandra São Bento Viegas | - CCMAR
Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005;280(29):26659-68. doi: ... 2005) Evolution of matrix and bone gamma -carboxyglutamic acid proteins in vertebrates. J Biol Chem. July; 280(29):26659-68. ... Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. Journal of Biological Chemistry. 2005;280(29): ... 2005). "Conserved Features of Matrix and Bone Gamma-Carboxyglutamic Acid Proteins in Vertebrates - An Evolutionary Point of ...
https://www.ccmar.ualg.pt/users/caviegas
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs.bvs.br/P/mnchg2014.txt
miRNA Details | Therapeutic Target DatabasemiRNA Details | Therapeutic Target Database
Transmembrane gamma-carboxyglutamic acid protein 1. Regulated Protein. TMG1_HUMAN [56] Tumor protein p53-inducible nuclear ... Nucleic Acids Res. 2009 Nov;37(20):e137. REF 38. A novel role of microRNA 17-5p in the modulation of circadian rhythm.Sci Rep. ... Nucleic Acids Res. 2009 Nov;37(20):e137. REF 14. Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - ... Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion.Nucleic Acids ...
https://db.idrblab.net/ttd/data/mirna/details/hsa-mir-17-5p
DeCSDeCS
3-propanetricarboxylic Acid gamma Carboxyglutamic Acid gamma-Carboxyglutamic Acid gamma-Carboxyglutamate - Narrower Concept UI ... gamma Carboxyglutamic Acid. gamma-Carboxyglutamate. gamma-Carboxyglutamic Acid. Tree number(s):. D02.241.081.901.400. D12.125. ... 1-Carboxyglutamic Acid - Preferred Concept UI. M0023166. Scope note. Found in various tissues, particularly in four blood- ... ácido 1-carboxiglutámico. Entry term(s). carboxiglutamato gamma carboxiglutamato-gamma gamma carboxiglutamato gamma- ...
https://decs.bvsalud.org/en/ths/resource/?id=2303
Glutamic Acid (Glu/E) < Proteinogenic Amino Acids (Canonical Amino Acids) << Amino Acids <<< Amino Acids and derivatives @...
... is an excitatory proteinogenic amino acid that may be interconverted to glutamine ... "Role of gamma-carboxyglutamic acid residues in the binding of factor IXa to platelets and in factor-X activation" Blood. 1992 ... Amino Acids and derivatives. ⌊Amino Acids. ⌊Proteinogenic Amino Acids (Canonical Amino Acids). ⌊Glutamic Acid (Glu/E) ... Glutamic Acid (Glu/E) "Glutamic Acid and derivatives" Glutamic Acids. In organic chemistry, Glutamic acid and derivatives are ...
https://wellnessadvantage.com/?dgl=70130
NHANES 1999-2000: Dietary Supplement Use 30-Day - File 1, Supplement Counts Data Documentation, Codebook, and Frequencies
a residue of an amino acid (e.g. (-carboxyglutamic acid also known as GLA) - as a complex of amino acids (e.g. natural amino ... AMINO ACIDS An ingredient is classified as an amino acid if it is an essential or nonessential amino acid. It can exist in: - ... An ingredient would not be classified as amino acid but as "Other" if it is: - an alpha-keto acid (an amino acid with its amino ... Aspartic Acid Leucine Threonine Theanine Cysteine Lysine Tryptophan SAM-e Glutamic Acid Methionine Tyrosine N-acetyl-cysteine ...
https://wwwn.cdc.gov/Nchs/Nhanes/1999-2000/DSQFILE1.htm
Dietary calcium requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age | Journal of Animal...Dietary calcium requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age | Journal of Animal...
A total of 420 1-day-old Arbor Acres male broilers were randomly assigned to 1 of 7 treatments with 6 replicates (10 birds per ... to meet all of the Ca metabolisms and bone development of broilers fed a conventional corn-soybean meal diet from 1 to 21 days ... so as to estimate dietary Ca requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age. ... Vitamin K dependence of a calcium-binding protein containing gamma-carboxyglutamic acid in chicken bone. J Biol Chem. 1978;253( ...
https://jasbsci.biomedcentral.com/articles/10.1186/s40104-021-00652-5
A Draft: Pathologic and Cardiovascular Calcification in Relation to Aging (2008-2010)A Draft: Pathologic and Cardiovascular Calcification in Relation to Aging (2008-2010)
25-Dihydroxyvitamin D3 stimulates the synthesis of matrix gamma-carboxyglutamic acid protein by osteosarcoma cells. Mutually ... Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):221-7.. Ectopic calcification of rat aortas and kidneys is reduced ... In theory vitamin B6, B12 and folic acid could exert modest effects via homocysteine metabolism [VanCampenhout2009]. While ... Catheters can be used to deliver various substances: First, physiochemical inhibitors e.g. acids, crystallisation inhibitors, ...
http://biogerontolgy.blogspot.com/2012/10/a-draft-pathologic-and-cardiovascular.html
Warfarin-induced vasculopathy. | Scholars@DukeWarfarin-induced vasculopathy. | [email protected]
Warfarin-induced vasculopathy.
https://scholars.duke.edu/display/pub748890
Vitamin K2 - WikipediaVitamin K2 - Wikipedia
... in conversion of peptide-bound glutamic acid (Glu) to γ-carboxy glutamic acid (Gla) in these proteins).[8] ... Many bacteria synthesize menaquinones from chorismic acid. They use it as a part of the electron transport chain, playing a ... Oxygen, heme, and menaquinones are needed for many species of lactic acid bacteria to conduct respiration.[32] ...
https://en.wikipedia.org/?curid=38233257
Fluoride Action Network | The case for eliminating the use of dietary fluoride supplements among young children.Fluoride Action Network | The case for eliminating the use of dietary fluoride supplements among young children.
... carboxyglutamic acid protein (BGLAP), secreted protein acidic and cysteine-rich (SPARC), vitamin D receptor (VDR), and matrix ... As estrogen receptor 1 (ESR1), collagen type 1 alpha 2 (COL1A2), bone ?- ... These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water. ...
https://fluoridealert.org/studytracker/19241/
Glutamates | Profiles RNS
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that ... A phase 1 study of TRC102, an inhibitor of base excision repair, and pemetrexed in patients with advanced solid tumors. Invest ... administered 1 day after pemetrexed 500 mg/m(2) every 21 days in patients with cancer. Invest New Drugs. 2013 Feb; 31(1):136-44 ...
https://profiles.umassmed.edu/display/123079
Factor IX - wikidocFactor IX - wikidoc
1cfh: STRUCTURE OF THE METAL-FREE GAMMA-CARBOXYGLUTAMIC ACID-RICH MEMBRANE BINDING REGION OF FACTOR IX BY TWO-DIMENSIONAL NMR ... Freedman SJ, Furie BC, Furie B, Baleja JD (Sep 1995). "Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich ... 1cfi: NMR STRUCTURE OF CALCIUM ION-BOUND GAMMA-CARBOXY-GLUTAMIC ACID-RICH DOMAIN OF FACTOR IX ... Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the ...
https://www.wikidoc.org/index.php/Nonacog_alfa
Find Research outputs - Experts@MinnesotaFind Research outputs - [email protected]
γ-carboxyglutamic acid distribution. Zytkovicz, T. H. & Nelsestuen, G. L., Sep 24 1976, In: BBA - General Subjects. 444, 2, p. ... Dunlop, P. C., Roon, R. J. & Even, H. L., Dec 1 1976, In: Journal of Bacteriology. 125, 3, p. 999-1004 6 p.. Research output: ... Buselmeier, T. J., Simmons, R. L., Najarian, J. S., Mauer, S. M., Matas, A. J. & Kjellstrand, C. M., Dec 1 1976, In: Nephron. ... Bruch, L. W., Cohen, P. I. & Webb, M. B., Sep 1976, In: Surface Science. 59, 1, p. 1-16 16 p.. Research output: Contribution to ...
https://experts.umn.edu/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&page=6480
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs2018.bvsalud.org/P/mnchg2014.txt
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs2016.bvsalud.org/E/mnchg2014.txt
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs2019.bvsalud.org/E/mnchg2014.txt
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs2014.bvsalud.org/I/mnchg2014.txt
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs2020.bvsalud.org/E/mnchg2014.txt
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs2015.bvsalud.org/E/mnchg2014.txt
MESH TREE NUMBER CHANGES - 2014 MeSH. July 29, 2013
Replaced for 2013 by Fatty Acid Synthase, Type I) Fatty Acid Synthetase Complex, Type II D5.500.562.437.500 D5.500.562.444 ... D8.811.641.249 Acid-Base Equilibrium G7.700.360.110 G7.700.345.110 Acidulated Phosphate Fluoride D1.29.260.700.675.374.25 ... D12.125.119.409 Glutamic Acid D12.125.67.750 D12.125.67.625.349 D12.125.119.450 D12.125.119.409.349 Glycerol-3-Phosphate ... Replaced for 2013 by Fatty Acid Synthase, Type II) Fatty Liver, Alcoholic C25.100.87.645.390 C25.775.100.87.645.390 Feedback, ...
https://decs2017.bvsalud.org/E/mnchg2014.txt
Publicações | - CCMARPublicações | - CCMAR
Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005;280(29):26659-68. doi: ... 2015;566(1):54-62. doi:10.1016/j.gene.2015.04.022. Simões B, Conceição N, Matias AC, Bragança J, Kelsh RN, M. Cancela L. ... 2006;126(1):89-101. doi:10.1007/s00418-005-0125-6. Simões B, Conceição N, Viegas CSB, et al. Identification of a promoter ... 2007;148(1):32-43. doi:10.1016/j.cbpb.2007.04.015. Martins RST, Deloffre LAM, Mylonas CC, Power DM, Canario AVM. Developmental ...
https://ccmar.ualg.pt/biblio2?f%5Bkeyword%5D=112
Ferritin - a multifaceted protein scaffold for biotherapeutics | Experimental & Molecular MedicineFerritin - a multifaceted protein scaffold for biotherapeutics | Experimental & Molecular Medicine
used γ-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP) to treat acute inflammatory ... A double-chambered protein nanocage loaded with thrombin receptor agonist peptide (TRAP) and gamma-carboxyglutamic acid of ... Design of PD-1-decorated nanocages targeting tumor-draining lymph node for promoting T cell activation. J. Control. Rel. 333, ... 1). The overall aim is to present a short list of the most interesting current and recent approaches to using ferritin in ...
https://www.nature.com/articles/s12276-022-00859-0?error=cookies_not_supported&code=2deaf8e7-5473-4cef-b8be-6ab983c74ca7
Vitamin K and Osteoporosis | Natural Medicine JournalVitamin K and Osteoporosis | Natural Medicine Journal
Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma- carboxyglutamic acid in response to altered intakes of ... Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma- carboxyglutamic acid in response to altered intakes of ... residues to gamma carboxyglutamic acid in vitamin K dependent proteins. This reaction allows the protein to bind calcium ions ... In general, vitamin K acts as a cofactor for the enzyme carboxylase, which catalyzes carboxylation of glutamic acid(Glu) ...
https://www.naturalmedicinejournal.com/journal/vitamin-k-and-osteoporosis
Purpura Fulminans: Practice Essentials, Background, Pathophysiology and EtiologyPurpura Fulminans: Practice Essentials, Background, Pathophysiology and Etiology
Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma. Biochemistry. 1979 ... patients with purpura fulminans require meticulous fluid management and may quickly develop electrolyte derangements and acid- ... 1] It may be classified as (1) neonatal, (2) idiopathic, or (3) acute infectious. Laboratory studies are the primary diagnostic ... ATIII deficiency is found in approximately 1 in 2000-5000 individuals. All family members should be tested if the family has a ...
https://emedicine.staging.medscape.com/article/2202749-overview
Gamma-carboxyglutaResiduesProteinProteinsOsteocalcinAcidicBoneTissuesCalcificationTranexamicPhylloquinoneVitaminDeficiencyDietaryBacteriaEntryStudiesPatientsMonthTotalFormation
Gamma-carboxygluta2
  • Alternate names: bone gamma-carboxyglutamic acid-containing protein, BGLAP. (takarabio.com)
  • Osteocalcin the major gamma carboxyglutamic acid containing protein of vertebrate bone has been purified from the bones of a specimen of Pachyornis elephantopus, a species of the extinct class of New Zealand ratite birds, the moas. (garvan.org.au)
Residues8
  • Rawala-Sheikh R. et al "Role of gamma-carboxyglutamic acid residues in the binding of factor IXa to platelets and in factor-X activation" Blood. (wellnessadvantage.com)
  • Menaquinone-4 (also known as menatetrenone from its four isoprene residues) is the most common type of vitamin K 2 in animal products since MK-4 is normally synthesized from vitamin K 1 in certain animal tissues (arterial walls, pancreas, and testes) by replacement of the phytyl tail with an unsaturated geranylgeranyl tail containing four isoprene units, thus yielding menaquinone-4 which is Water Soluble in nature. (wikipedia.org)
  • METHODS AND METHODS: CT-001 has 4 N-glycans (T106N/N145/V253N/N322) with terminal sialic acid residues removed to promote active clearance via the asialoglycoprotein receptor, and P10Q/K32E substitutions introduced to its gamma-carboxyglutamic acid (Gla) domain for enhanced phospholipid affinity and activity. (bvsalud.org)
  • The enzyme gamma-glutamyl carboxylase, in the presence of vitamin K, converts the glutamic acid residues to gamma-carboxyglutamic acid residues. (medscape.com)
  • These gamma-carboxyglutamic acid residues are necessary for the binding of prothrombin to phospholipids on platelet membranes. (medscape.com)
  • Annotation note 06 - For cross-link modifications, the number following 'Cross-link' in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. (githubusercontent.com)
  • M171) was raised against human osteocalcin peptide and specifically recognizes human osteocalcin with decarboxylated glutamic acid residues. (takarabio.com)
  • M184) was obtained by fusing mouse myeloma cell-line P3U1 with C57BL6 mouse spleen cells following immunization with keyhole limpet hemocyanin (KLH) conjugated to human osteocalcin peptide (amino acid residues 1-6). (takarabio.com)
Protein6
  • In our body, 1-Carboxyglutamic Acid , an acidic dicarboxylic amino acid and a tricarboxylic acid , is a glutamic acid (GLU) derivative, found in various tissues, particularly in four blood-clotting proteins including Prothrombin , in kidney protein, in bone protein, and in the protein present in various ectopic calcifications. (wellnessadvantage.com)
  • In protein science, Pyrrolidonecarboxylic Acid as a type of imino acid is a cyclized derivative of l-glutamic acid. (wellnessadvantage.com)
  • This recombinant protein (r-Antidote, PRT064445) is catalytically inactive and lacks the membrane-binding γ-carboxyglutamic acid domain of native fXa but retains the ability of native fXa to bind direct fXa inhibitors as well as low molecular weight heparin-activated antithrombin III (ATIII). (nih.gov)
  • Our recent studies showed that FVIIa binds endothelial cell protein C receptor (EPCR) and induces protease-activated receptor 1 (PAR1)-mediated biased signaling. (bvsalud.org)
  • A lack of calcification inhibitory factors (e.g. matrix gamma-carboxyglutamic acid protein, pyrophosphate, fetuin-A, osteopontin and osteoprotegerin) also plays a role in the imbalance between osteogenic and osteoclastic mechanisms. (icrjournal.com)
  • This calcification is caused by high concentration of calcium and phosphate that can be reduced by specific protein known as Matrix γ-carboxyglutamic acid protein (MGP). (home-remedies-for-you.com)
Proteins2
  • K vitamins play an essential role as cofactor for the enzyme γ-glutamyl carboxylase, which is involved in vitamin K-dependent carboxylation of the gla domain in "Gla proteins" (i.e., in conversion of peptide-bound glutamic acid (Glu) to γ-carboxy glutamic acid (Gla) in these proteins). (wikipedia.org)
  • it is needed for the conversion of 10-12 glutamic acid residue on the NH 2 -terminal of precursor coagulation proteins into the action form of gamma-carboxyglutamic acid (which occurs via VK-dependent gamma-glutamyl carboxylase). (medscape.com)
Osteocalcin3
  • This coated plate contains a monoclonal antibody that distinguishes human from bovine osteocalcin via their amino acid differences at positions 3 and 4 in the N-terminus. (takarabio.com)
  • This kit is designed to precisely differentiate bovine and human osteocalcins, using a capture antibody-coated plate with a human osteocalcin-specific monoclonal antibody that recognizes the distinct difference in the amino acids at positions 3 and 4 from the N-terminus. (takarabio.com)
  • This monoclonal antibody was obtained by fusing the mouse myeloma cell-line P3U1 with spleen cells of C57BL6 mouse after immunization with KLH-conjugated peptide from human osteocalcin sequence (amino acids 1-6 YLYQWL). (takarabio.com)
Acidic1
  • In our body, the non-essential proteinogenic excitatory amino acid , Glutamic Acid (GLU/E) , an acidic amino acid and an dicarboxylic amino acid , that maybe interconverted to glutamine (l-glutamine) . (wellnessadvantage.com)
Bone5
  • Therefore, the present study was carried out to investigate the effect of dietary Ca level on growth performance, serum parameters, bone characteristics and Ca metabolism-related gene expressions, so as to estimate dietary Ca requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age. (biomedcentral.com)
  • The results from the present study indicate that the Ca requirements would be about 0.60% to obtain the best growth rate, and 1.00% to meet all of the Ca metabolisms and bone development of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age. (biomedcentral.com)
  • Calcium (Ca) is an essential mineral element, and plays an important role in many biological processes, such as enzyme activation, intracellular signaling, acid-base balance and bone mineralization [ 1 ]. (biomedcentral.com)
  • Furthermore, the starter phase (1 to 21 d) is a critical period for bone development of broilers. (biomedcentral.com)
  • Ideally, prevention of bone loss through nutritional repletion would begin prior to a person's age of peak bone mass at 18-24 years old, as higher peak mass provides protection from later osteoporosis.3 For those beyond peak bone mass years, age-related bone density decline is expected to be 0.5-1% annually, with an increase to 2-3% in postmenopausal women. (naturalmedicinejournal.com)
Tissues2
  • In our body, Formiminoglutamic Acid (FIGLU) , an intermediate metabolite, in the intermediate step in the catabolic metabolism of the amino acid l-histidine to l-glutamic acid (glutamate) in our tissues. (wellnessadvantage.com)
  • It is known that production of MK-4 from dietary plant vitamin K 1 can be accomplished by animal tissues alone, as it proceeds in germ-free rodents. (wikipedia.org)
Calcification2
  • Vascular calcification occurs in both the intima and the media of arteries, and there is evidence that these two sites of calcification are distinct entities (table 1 ). (bmj.com)
  • 1 In contrast, medial calcification occurs independently of intimal calcification and atherosclerosis. (bmj.com)
Tranexamic2
  • Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding. (wikidoc.org)
  • this did not change with addition of tranexamic acid and/or fibrinogen concentrate. (bvsalud.org)
Phylloquinone4
  • Vitamin K 2 or menaquinone ( MK ) ( / ˌ m ɛ n ə ˈ k w ɪ n oʊ n / ) is one of three types of vitamin K , the other two being vitamin K 1 ( phylloquinone ) and K 3 ( menadione ). (wikipedia.org)
  • MK-7 may be converted from phylloquinone (K 1 ) in the colon by Escherichia coli bacteria . (wikipedia.org)
  • Both phylloquinone and menaquinones have a 2-methyl-1,4 napthoquinone ring backbone with an isoprenoid side chain at the C3 position (Figure 1). (naturalmedicinejournal.com)
  • Food concentration of phylloquinone is highest in plants, especially leafy greens, with a lower concentration found in meats, cheeses, fruits and bread (Table 1). (naturalmedicinejournal.com)
Vitamin6
  • 1 ] identified another new vitamin K-dependent plasma glycoprotein. (stoptheclot.org)
  • Furie B. et al "Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid" Blood. (wellnessadvantage.com)
  • K 2 is both a tissue and bacterial product (derived from vitamin K 1 in both cases) and is usually found in animal products or fermented foods. (wikipedia.org)
  • The most common in the human diet is the short-chain, water-soluble menatetrenone (MK-4), which is usually produced by tissue and/or bacterial conversion of vitamin K 1 , and is commonly found in animal products. (wikipedia.org)
  • This homolog of vitamin K 2 may have enzyme functions distinct from those of vitamin K 1 . (wikipedia.org)
  • The mechanism of action of vitamin K 2 is similar to vitamin K 1 . (wikipedia.org)
Deficiency1
  • Although PS deficiency is uncommon in the general population, it is found in approximately 2% of unselected patients and 1-13% of thrombophilic patients with VTE respectively [ 8,9 ]. (stoptheclot.org)
Dietary2
  • They are shown a hand card that lists examples of dietary supplements (Appendix 1: Handcard DSQ1). (cdc.gov)
  • If a healthy person is subject to a complete dietary absence of VK, his/her VK reserve is adequate for 1 week. (medscape.com)
Bacteria1
  • [ 1 ] VK is also synthesized by colonic bacteria. (medscape.com)
Entry1
  • Annotation note 02 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol '#' and a 3 or 4 character label. (githubusercontent.com)
Studies1
Patients3
  • A phase 1 study of TRC102, an inhibitor of base excision repair, and pemetrexed in patients with advanced solid tumors. (umassmed.edu)
  • 1 Coronary angiography opened the possibility of expanding these observations to living patients and offered revascularisation options. (icrjournal.com)
  • For HBeAg-positive patients, there were significant declines in qHBsAg level between baseline and 3M, 12 and 24M (P=0.0281), and 36 and 48M (P=0.01 1 6). (pdk1signal.com)
Month1
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution. (novusbio.com)
Total1
  • A total of 420 1-day-old Arbor Acres male broilers were randomly assigned to 1 of 7 treatments with 6 replicates (10 birds per cage) and fed the corn-soybean meal diets containing 0.60%, 0.70%, 0.80%, 0.90%, 1.00%, 1.10% or 1.20% Ca for 21 days. (biomedcentral.com)
Formation1
  • In the body, the metabolism of Glutamic Acid (Glutamate) can result in the formation of GABA (Gamma-Aminobutyric Acid) . (wellnessadvantage.com)
SCOPe 2.08: Species: Pig (Sus scrofa) [TaxId: 9823]
SCOPe 2.08: Species: Pig (Sus scrofa) [TaxId: 9823] (scop.berkeley.edu)
SCOPe 2.07: Protein: Coagulation factor X
SCOPe 2.07: Protein: Coagulation factor X (scop.berkeley.edu)
SCOPe 2.08: Domain d1pfxl3: 1pfx L:1-46
SCOPe 2.08: Domain d1pfxl3: 1pfx L:1-46 (scop.berkeley.edu)
DailyMed - WARFARIN SODIUM tablet
DailyMed - WARFARIN SODIUM tablet (dailymed.nlm.nih.gov)
Carla Alexandra São Bento Viegas | - CCMAR
Carla Alexandra São Bento Viegas | - CCMAR (ccmar.ualg.pt/users/caviegas/)
A Draft: Pathologic and Cardiovascular Calcification in Relation to Aging (2008-2010)
A Draft: Pathologic and Cardiovascular Calcification in Relation to Aging (2008-2010) (biogerontolgy.blogspot.com)
Vitamin K2 - Wikipedia
Vitamin K2 - Wikipedia (en.wikipedia.org)
Vitamin K and Osteoporosis | Natural Medicine Journal
Vitamin K and Osteoporosis | Natural Medicine Journal (naturalmedicinejournal.com)
Citrates | Profiles RNS
Citrates | Profiles RNS (profiles.wakehealth.edu)
Factor X Deficiency: Practice Essentials, Background, Pathophysiology
Factor X Deficiency: Practice Essentials, Background, Pathophysiology (medscape.com)
CREST Syndrome: Background, Pathophysiology, Etiology
CREST Syndrome: Background, Pathophysiology, Etiology (medscape.com)
Dietary calcium requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age | Journal of Animal...
Dietary calcium requirements of broilers fed a conventional corn-soybean meal diet from 1 to 21 days of age | Journal of Animal... (jasbsci.biomedcentral.com)
Protein S Deficiency: Practice Essentials, Pathophysiology, Etiology
Protein S Deficiency: Practice Essentials, Pathophysiology, Etiology (medscape.com)
ZFIN Gene: f10
ZFIN Gene: f10 (zfin.org)
SustainPineDB
SustainPineDB (scbi.uma.es)
PDF) Electron Capture Dissociation Mass Spectrometric Analysis of Lysine-Phosphorylated Peptides
PDF) Electron Capture Dissociation Mass Spectrometric Analysis of Lysine-Phosphorylated Peptides (researchgate.net)
Comment définir sa mission de vie | Leçons de vie
Comment définir sa mission de vie | Leçons de vie (lecons-de-vie.com)
ISMARA results: SOX5.p2
ISMARA results: SOX5.p2 (ismara.unibas.ch)
These highlights do not include all the information needed to use warfarin sodium safely and effectively. See full prescribing...
These highlights do not include all the information needed to use warfarin sodium safely and effectively. See full prescribing... (dailymed.nlm.nih.gov)
These highlights do not include all the information needed to use WARFARIN SODIUM TABLETS safely and effectively. See full...
These highlights do not include all the information needed to use WARFARIN SODIUM TABLETS safely and effectively. See full... (dailymed.nlm.nih.gov)
These highlights do not include all the information needed to use WARFARIN SODIUM TABLETS safely and effectively. See full...
These highlights do not include all the information needed to use WARFARIN SODIUM TABLETS safely and effectively. See full... (dailymed.nlm.nih.gov)
These highlights do not include all the information needed to use WARFARIN SODIUM TABLETS safely and effectively. See full...
These highlights do not include all the information needed to use WARFARIN SODIUM TABLETS safely and effectively. See full... (dailymed.nlm.nih.gov)