Chemicals and DrugsPhenomena and Processes
1-Alkyl-2-acetylglycerophosphocholine EsteraseEsterasesCarboxylic Ester HydrolasesNaphthol AS D EsteraseSterol EsteraseAcetylesteraseCarboxylesteraseEstersIsoflurophateAlkylation
1-Alkyl-2-acetylglycerophosphocholine Esterase
A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Esterases
Carboxylic Ester Hydrolases
Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.
Naphthol AS D Esterase
Hydrolytic enzyme activity used as a histocytochemical test for the presence of esterases in tissue. Substrate used is 3-hydroxy-4'-nitro-2-naphthanilide chloroacetate (naphthol AS-D).
Sterol Esterase
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
Acetylesterase
An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1.1.6.
Carboxylesterase
Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.
Esters
Isoflurophate
A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
Alkylation
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor. (1/562)

A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is described for the first time. This inhibitor, SB-222657 (Ki=40+/-3 nM, kobs/[I]=6. 6x10(5) M-1.s-1), is inactive against paraoxonase, is a poor inhibitor of lecithin:cholesterol acyltransferase and has been used to investigate the role of Lp-PLA2 in the oxidative modification of lipoproteins. Although pretreatment with SB-222657 did not affect the kinetics of low-density lipoprotein (LDL) oxidation by Cu2+ or an azo free-radical generator as determined by assay of lipid hydroperoxides (LOOHs), conjugated dienes and thiobarbituric acid-reacting substances, in both cases it inhibited the elevation in lysophosphatidylcholine content. Moreover, the significantly increased monocyte chemoattractant activity found in a non-esterified fatty acid fraction from LDL oxidized by Cu2+ was also prevented by pretreatment with SB-222657, with an IC50 value of 5.0+/-0.4 nM. The less potent diastereoisomer of SB-222657, SB-223777 (Ki=6.3+/-0.5 microM, kobs/[I]=1.6x10(4) M-1.s-1), was found to be significantly less active in both assays. Thus, in addition to generating lysophosphatidylcholine, a known biologically active lipid, these results demonstrate that Lp-PLA2 is capable of generating oxidized non-esterified fatty acid moieties that are also bioactive. These findings are consistent with our proposal that Lp-PLA2 has a predominantly pro-inflammatory role in atherogenesis. Finally, similar studies have demonstrated that a different situation exists during the oxidation of high-density lipoprotein, with enzyme(s) other than Lp-PLA2 apparently being responsible for generating lysophosphatidylcholine.  (+info)

Association of the inflammatory state in active juvenile rheumatoid arthritis with hypo-high-density lipoproteinemia and reduced lipoprotein-associated platelet-activating factor acetylhydrolase activity. (2/562)

OBJECTIVE: To investigate the relationship between the quantitative and qualitative abnormalities of apolipoprotein B (Apo B)- and Apo A-I-containing lipoproteins and between lipoprotein-associated platelet-activating factor acetylhydrolase (PAF-AH) activity in patients with juvenile rheumatoid arthritis (JRA) as a function of the inflammatory state. METHODS: Twenty-six JRA patients and 22 age- and sex-matched control subjects with normal lipid levels participated in the study. Fourteen patients had active disease, and 12 had inactive disease. Plasma lipoproteins were fractionated by gradient ultracentrifugation into 9 subfractions, and their chemical composition and mass were determined. The PAF-AH activity associated with lipoprotein subfractions and the activity in plasma were also measured. RESULTS: Patients with active JRA had significantly lower plasma total cholesterol and high-density lipoprotein (HDL) cholesterol levels as compared with controls, due to the decrease in the mass of both the HDL2 and HDL3 subfractions. Patients with active JRA also had higher plasma triglyceride levels, mainly due to the higher triglyceride content of the very low-density lipoprotein plus the intermediate-density lipoprotein subfraction. The plasma PAF-AH activity in patients with active JRA was lower than that in controls, mainly due to the decrease in PAF-AH activity associated with the intermediate and dense low-density lipoprotein subclasses. The lipid abnormalities and the reduction in plasma PAF-AH activity were significantly correlated with plasma C-reactive protein levels and were not observed in patients with inactive JRA. CONCLUSION: This is the first study to show that patients with active JRA exhibit low levels of HDL2 and HDL3 and are deficient in plasma PAF-AH activity. These alterations suggest that active JRA is associated with partial loss of the antiinflammatory activity of plasma Apo B- and Apo A-I-containing lipoproteins.  (+info)

Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death. (3/562)

Glutamate receptors modulate multiple signaling pathways, several of which involve mitogen-activated protein (MAP) kinases, with subsequent physiological or pathological consequences. Here we report that stimulation of the N-methyl-D-aspartate (NMDA) receptor, using platelet-activating factor (PAF) as a messenger, activates MAP kinases, including c-Jun NH2-terminal kinase, p38, and extracellular signal-regulated kinase, in primary cultures of hippocampal neurons. Activation of the metabotropic glutamate receptor (mGluR) blocks this NMDA-signaling through PAF and MAP kinases, and the resultant cell death. Recombinant PAF-acetylhydrolase degrades PAF generated by NMDA-receptor activation; the hetrazepine BN50730 (an intracellular PAF receptor antagonist) also inhibits both NMDA-stimulated MAP kinases and neuronal cell death. The finding that the NMDA receptor-PAF-MAP kinase signaling pathway is attenuated by mGluR activation highlights the exquisite interplay between glutamate receptors in the decision making process between neuronal survival and death.  (+info)

Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein. (4/562)

The platelet-activating factor acetylhydrolases are enzymes that were initially characterized by their ability to hydrolyze platelet-activating factor (PAF). In human plasma, PAF acetylhydrolase (EC 3.1.1.47) circulates in a complex with low density lipoproteins (LDL) and high density lipoproteins (HDL). This association defines the physical state of PAF acetylhydrolase, confers a long half-life, and is a major determinant of its catalytic efficiency in vivo. The lipoprotein-associated enzyme accounts for all of the PAF hydrolysis in plasma but only two-thirds of the protein mass. To characterize the enzyme-lipoprotein interaction, we employed site-directed mutagenesis techniques. Two domains within the primary sequence of human PAF acetylhydrolase, tyrosine 205 and residues 115 and 116, were important for its binding to LDL. Mutation or deletion of those sequences prevented the association of the enzyme with lipoproteins. When residues 115 and 116 from human PAF acetylhydrolase were introduced into mouse PAF acetylhydrolase (which normally does not associate with LDL), the mutant mouse PAF acetylhydrolase associated with lipoproteins. To analyze the role of apolipoprotein (apo) B100 in the formation of the PAF acetylhydrolase-LDL complex, we tested the ability of PAF acetylhydrolase to bind to lipoproteins containing truncated forms of apoB. These studies indicated that the carboxyl terminus of apoB plays a key role in the association of PAF acetylhydrolase with LDL. These data on the molecular basis of the PAF acetylhydrolase-LDL association provide a new level of understanding regarding the pathway for the catabolism of PAF in human blood.  (+info)

Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma. (5/562)

Asthma, a family of airway disorders characterized by airway inflammation, has an increasing incidence worldwide. Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma. Its proinflammatory actions are antagonized by PAF acetylhydrolase. A missense mutation (V279F) in the PAF acetylhydrolase gene results in the complete loss of activity, which occurs in 4% of the Japanese population. We asked if PAF acetylhydrolase deficiency correlates with the incidence and severity of asthma in Japan. We found that the prevalence of PAF acetylhydrolase deficiency is higher in Japanese asthmatics than healthy subjects and that the severity of this syndrome is highest in homozygous-deficient subjects. We conclude that the PAF acetylhydrolase gene is a modulating locus for the severity of asthma.  (+info)

Platelet-activating factor may act as an endogenous pulse generator for sheep of luteolytic PGF2alpha release. (6/562)

Pulsatile release of uterine prostaglandin F2alpha (PGF2alpha) induces luteolysis in ruminants. However, the mechanism(s) that initiates and maintains luteolysis has not been defined. The present study tested the hypothesis that the endogenous PGF2alpha pulse generator is uterine-derived platelet-activating factor (PAF). Ovariectomized ewes were given exogenous progesterone (P), estradiol (E), or both (P+E, mimicking the normal luteal phase). Only ewes treated with steroids released PAF into the uterine lumen and had increased PAF:acetylhydrolase activity in the uterine lumen. Steroid treatment also influenced the capacity of the uterus to release PGF2alpha in response to exogenous PAF. PAF infusion did not affect plasma PGF2alpha metabolite (PGFM) levels in control (no steroid treatment) ewes but increased plasma PGFM levels in P+E ewes (P < 0.001) and ewes treated with P or E alone (P < 0.05). Infusion of PAF followed by or coincident with oxytocin (OT) acted in a synergistic manner to increase plasma PGFM levels. Repeated infusion of PAF into the uterus at 1-h intervals induced tachyphylaxis of the PGFM response to PAF; however, sensitivity of the uterus to PAF returned spontaneously by the 6th h. Interferon-tau (IFN-tau) inhibits pulsatile release of PGF2alpha during pregnancy to prevent luteolysis. Exogenous recombinant ovine IFN-tau (50 microgram) inhibited the uterine response to PAF alone or the combined effects of PAF and OT. These results indicate that uterine PAF fulfills many of the criteria for an endogenous PGF2alpha pulse-generator: steroid induction of PAF production and uterine responsiveness to PAF-induced release of PGF; synergistic stimulation of PAF-induced PGF release by OT; inhibition of PAF effects by IFN-tau; and PAF's ability to induce pulses of PGF with a periodicity during a period of chronic exposure of the uterus to PAF.  (+info)

Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma. (7/562)

A region of 150 kb has been analysed around a previously isolated, lymphoma associated, translocation breakpoint located at chromosome band 11q23. This balanced and reciprocal translocation, t(11;14)(q32;q23), has been shown to result in the fusion between chromosome 11 specific sequence and the switch gamma4 region of the IGH locus. The LPC gene, encoding a novel proprotein convertase belonging to the furin family, has been identified in this region. In order to characterize further the region surrounding the translocation, we have determined the detailed structure of LPC. Here we show that LPC consists of at least 16 exons covering 25 kb, and that there is a partial duplication, involving mobile genetic elements and containing LPC exons 13-17 in a tail-tail configuration at 65 kb downstream. Since the chromosomal breakpoint lay between these two structures, the intervening region was further analysed and shown to contain at least two unrelated genes. The previously known SM22 gene was localized close to the 3' tail of LPC. Furthermore, we identified the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) at the chromosomal breakpoint. The position of another previously identified breakpoint was also located to within the first intron of this gene. Altogether, our results give evidence of a genomic instability of this area of 11q23 and show that Pafah1a2 and not LPC is the gene disrupted by the translocation, suggesting that deregulated Pafah1a2 may have a role in lymphomagenesis.  (+info)

All ApoB-containing lipoproteins induce monocyte chemotaxis and adhesion when minimally modified. Modulation of lipoprotein bioactivity by platelet-activating factor acetylhydrolase. (8/562)

Mildly oxidized LDL has many proinflammatory properties, including the stimulation of monocyte chemotaxis and adhesion, that are important in the development of atherosclerosis. Although ApoB-containing lipoproteins other than LDL may enter the artery wall and undergo oxidation, very little is known regarding their proinflammatory potential. LDL, IDL, VLDL, postprandial remnant particles, and chylomicrons were mildly oxidized by fibroblasts overexpressing 15-lipoxygenase (15-LO) and tested for their ability to stimulate monocyte chemotaxis and adhesion to endothelial cells. When conditioned on 15-LO cells, LDL, IDL, but not VLDL increased monocyte chemotaxis and adhesion approximately 4-fold. Chylomicrons and postprandial remnant particles were also bioactive. Although chylomicrons had a high 18:1/18:2 ratio, similar to that of VLDL, and should presumably be less susceptible to oxidation, they contained (in contrast to VLDL) essentially no platelet-activating factor acetylhydrolase (PAF-AH) activity. Because PAF-AH activity of lipoproteins may be reduced in vivo by oxidation or glycation, LDL, IDL, and VLDL were treated in vitro to reduce PAF-AH activity and then conditioned on 15-lipoxygenase cells. All 3 PAF-AH-depleted lipoproteins, including VLDL, exhibited increased stimulation of monocyte chemotaxis and adhesion. In a similar manner, lipoproteins from Japanese subjects with a deficiency of plasma PAF-AH activity were also markedly more bioactive, and stimulated monocyte adhesion nearly 2-fold compared with lipoproteins from Japanese control subjects with normal plasma PAF-AH. For each lipoprotein, bioactivity resided in the lipid fraction and monocyte adhesion could be blocked by PAF-receptor antagonists. These data suggest that the susceptibility of plasma lipoproteins to develop proinflammatory activity is in part related to their 18:1/18:2 ratio and PAF-AH activity, and that bioactive phospholipids similar to PAF are generated during oxidation of each lipoprotein. Moreover, LDL, IDL, postprandial remnant particles, and chylomicrons and PAF-AH-depleted VLDL all give rise to proinflammatory lipids when mildly oxidized.  (+info)

Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein | Biochemical...Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein | Biochemical...
In this study, we demonstrate the presence of a transacetylase activity in human plasma low-density lipoprotein (LDL) that transfers short-chain fatty acids from platelet-activating factor (PAF) and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids (lyso-PL). We show evidence that both PAF acetylhydrolase (PAF-AH) and transacetylase activities are inhibited to the same extent by serine esterase inhibitors, are resistant to heat treatment, and exhibit identical distributions in lipoprotein classes and in LDL subfractions. Additionally, the competitive inhibition of PAF-AH by lyso-PL, and the evidence that the recombinant PAF-AH also showed a similar transacetylase activity, suggest that PAF-AH is responsible for both activities. Using PAF as a donor molecule and lyso-PAF (1-O-alkyl-sn-glycero-3-phosphocholine) as an acceptor, the transacetylase activity showed typical allosteric kinetics, due to the positive co-operativity of the substrates, with apparent Vmax = ...
http://www.biochemj.org/content/357/2/457
Lipoprotein-associated phospholipase A2 - WikipediaLipoprotein-associated phospholipase A2 - Wikipedia
Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases. In the blood it travels mainly with low-density lipoprotein (LDL). Less than 20% is associated with high-density lipoprotein HDL. It is an enzyme produced by inflammatory cells and hydrolyzes oxidized phospholipids in LDL. Lp-PLA2 is platelet-activating factor (PAF) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate. Lp-PLA2 is involved in the development of atherosclerosis, an observation that has prompted interest as a possible therapeutic target (see, e.g. the investigational drug Darapladib). In human atherosclerotic lesions, 2 main ...
https://en.wikipedia.org/wiki/Lipoprotein-associated_phospholipase_A2
The Role of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Cardiovascular Disease | Bentham ScienceThe Role of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Cardiovascular Disease | Bentham Science
Title: The Role of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Cardiovascular Disease. VOLUME: 6 ISSUE: 2. Author(s):Ignatios Ikonomidis, Christos A. Michalakeas, John Lekakis, John Parissis and Maria Anastasiou-Nana. Affiliation:2nd Cardiology Department, University of Athens, Attikon Hospital, Perikleous 19, N. Chalkidona, Athens 14343, Greece.. Keywords:Lp-PLA2, PAF-AH, inflammatory biomarkers, cardiovascular disease. Abstract: Lipoprotein-associated Phospholipase A2 (Lp-PLA2) is an enzyme that belongs to the A2 Phospholipase superfamily and is produced by inflammatory cells that are involved in the process of atherogenesis. Even though there is controversy in current bibliography whether Lp-PLA2 exerts proatherogenic or anti-atherogenic properties, the weight of evidence suggests a pro-atherogenic role for this protein. Lp-PLA2 is detected in human atherosclerotic lesions and elevated Lp-PLA2 levels are associated with an increased risk of cardiovascular events and adverse events in ...
http://www.eurekaselect.com/87689/article
PAFAH2 - WikipediaPAFAH2 - Wikipedia
Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene. It is one of several PAF acetylhydrolases. This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. GRCh38: Ensembl release 89: ENSG00000158006 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000037366 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Hattori K, Adachi H, Matsuzawa A, Yamamoto K, Tsujimoto M, Aoki J, Hattori M, Arai H, Inoue K ...
https://en.wikipedia.org/wiki/PAFAH2
openarchives.gr | Plasma and Lp(a)-associated PAF-acetylhydrolase activity in uremic patients undergoing different dialysis...openarchives.gr | Plasma and Lp(a)-associated PAF-acetylhydrolase activity in uremic patients undergoing different dialysis...
Πανεπιστήμιο Ιωαννίνων. Ιδρυματικό Αποθετήριο Ολυμπιάς.1999 . Creators: Milionis, H. J.. Contributors: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας, Milionis, H. J..Background. Platelet-activating factor (PAF) is a potent inflammatory mediator associated with several physiopathological conditions, including renal diseases. PAF is degraded to the inactive metabolite lyso-PAF by PAF-acetylhydrolase (PAF-AH), which is considered as a potent anti-inflammatory and anti-atherogenic enzyme associated with lipoproteins. In this study, we evaluated the plasma- and lipoprotein(a) [Lp(a)]associated PAF-AH activity in relationship to plasma lipid parameters and Lp(a) isoform size in patients with mild/moderate chronic renal failure (CRF), as well as in hemodialysis (HD) and chronic ambulatory peritoneal dialysis (CAPD) patients. Methods. We studied 74 patients undergoing maintenance HD, 44
https://www.openarchives.gr/aggregator-openarchives/edm/uoi/000030-123456789_8855
Structure Cluster - 1ES9: X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR...Structure Cluster - 1ES9: X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR...
1ES9: The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib).
http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1ES9
Single and Multiple Dose Pharmacokinetics, Pharmacodynamics and Safety of the Novel Lipoprotein-Associated Phospholipase A2...Single and Multiple Dose Pharmacokinetics, Pharmacodynamics and Safety of the Novel Lipoprotein-Associated Phospholipase A2...
Background and Objectives Darapladib is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. This study evaluated the pharmacokinetics, pharmacodynamics and safety of darapladib in healthy Chinese subjects. Methods Twenty-four subjects received darapladib 160 mg orally, approximately 1 hour after a standard breakfast, as a single dose and once daily for 28 days. Non-compartmental methods were used to determine the single and multiple dose pharmacokinetics of darapladib and its metabolite SB-553253. Repeat dose Lp-PLA2 activity and safety were evaluated. Results Systemic exposure (AUC(0-T), Cmax geometric mean (CVb%)) of darapladib was higher after multiple-dosing (519 ng.h/mL (33.3%), 34.4 ng/mL (49.9%)) compared to single-dose administration (153 ng.h/mL (69.0%), 17.9 ng/mL (55.2%). The steady-state accumulation ratio was less than unity (Rs = 0.80), indicating time-dependent pharmacokinetics of darapladib. Darapladib steady-state was reached by Day 14 of once daily dosing. Systemic
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139862
Lipoprotein associated phospholipase A2 measurement - Loyola University Health SystemLipoprotein associated phospholipase A2 measurement - Loyola University Health System
1] Sudhir K: Clinical review: Lipoprotein-associated phospholipase A2, a novel inflammatory biomarker and independent risk predictor for cardiovascular disease. J Clin Endocrinol Metab 2005; 90(5):3100-3105. [2] Koenig W, Khuseyinova N, Lowel H, et al: Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany. Circulation 2004; 110(14):1903-1908. [3] Ballantyne CM, Hoogeveen RC, Bang H, et al: Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study. Circulation 2004; 109(7):837-842. [4] Brilakis ES, McConnell JP, Lennon RJ, et al: Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic ...
http://loyolauniversity.adam.com/content.aspx?productId=49&pid=49&gid=150505
Lipoprotein-Associated Phospholipase A2 Activity Improves Risk Discrimination of Incident Coronary Heart Disease Among Women
Background This study sought to determine the relation between and discriminative capability of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and coronary heart disease (CHD) in a large population of disease-free women.Methods Among participants of the Nurses Health Study who provided a blood sample, there were 421 cases of incident myocardial infarction during 14 years of follow-up. Controls were matched to cases 2:1 using risk set sampling based on age, smoking, and blood draw date.Results After conditioning on the matching factors, Lp-PLA(2) activity was significantly associated with myocardial infarction (relative risk [RR] 2.86 for extreme quartiles, 95% CI 1.98-4.12). Upon additional adjustment for lipid, inflammatory, and clinical risk factors, the RR remained statistically significant (RR 1.75, 95% CI 1.09-2.84). The discriminative capability of Lp-PLA(2) was assessed by comparing the area below the receiver operating characteristic curves for models with and without Lp-PLA(2) ...
https://dash.harvard.edu/handle/1/41247225
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart...
AIMS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates proinflammatory and proatherogenic compounds in the arterial vascular wall and is a potential therapeutic target in coronary heart disease (CHD). We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association study as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. METHODS AND RESULTS: In meta-analyses of findings from five population-based studies, comprising 13 664 subjects, variants at two loci (PLA2G7, CETP) were associated with Lp-PLA2 mass. The strongest signal was at rs1805017 in PLA2G7 [P = 2.4 × 10(-23), log Lp-PLA2 difference per allele (beta): 0.043]. Variants at six loci were associated with Lp-PLA2 activity (PLA2G7, APOC1, CELSR2, LDL, ZNF259, SCARB1), among which the strongest signals were at rs4420638, near the APOE-APOC1-APOC4-APOC2 cluster [P = 4.9 × 10(-30); log Lp-PLA2 difference per allele (beta): -0.054]. There were no significant gene
https://www.cardioscience.ox.ac.uk/publications/914389
Effect of Treatment for 12 Weeks With Rilapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, on Arterial Inflammation...Effect of Treatment for 12 Weeks With Rilapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, on Arterial Inflammation...
To the Editor:. Previous reports have demonstrated that lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzymatic inflammatory biomarker, is associated with increased risk of cardiovascular events (1). Lp-PLA2 mediates formation of bioactive mediators (lysophosphatidyl choline and oxidized nonesterified fatty acids) known to elicit several deleterious inflammatory responses involved in the pathobiology of atherosclerosis. Lysophosphatidyl choline serves as a potent chemoattractant for monocytes, resulting in foam cell accumulation within the arterial wall. Additionally, Lp-PLA2 has been detected in rupture-prone and ruptured atherosclerotic plaques. Taken together, the data suggests that inhibition of Lp-PLA2 may attenuate intimal macrophage accumulation and consequently stabilize atherosclerotic plaque.. Positron emission tomography (PET) imaging with 18F-fluorodeoxyglucose (FDG) is a validated imaging technique widely used to quantify vascular inflammation within atheroma. In vivo ...
http://www.onlinejacc.org/content/63/1/86
Is Lipoprotein-Associated Phospholipase A2a Link between Inflammation and Subclinical Atherosclerosis inRheumatoid Arthritis?Is Lipoprotein-Associated Phospholipase A2a Link between Inflammation and Subclinical Atherosclerosis inRheumatoid Arthritis?
Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Methods. Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study. From these, all patients ,= 60 years (n = 71) were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5). Forty age-and sex-matched controls were included. The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5. Results. There was no significant difference in the level of Lp-PLA2 between patients with RA and controls (p , 0.05). In simple linear regression models among patients with RA, Lp-PLA2 at ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A876363&c=12&searchType=SIMPLE&language=sv&query=&af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A63514%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non...Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non...
AIMS: To identify factors that influence plasma levels and assess the prognostic value of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in a prospective, population-based survey of the epidemiology and pathogenesis of atherosclerosis.. METHODS AND RESULTS: The Bruneck study is a prospective, population-based survey initiated in 1990. Lp-PLA2 activity and baseline variables for the current analysis were measured in 765 subjects aged 45-84 years in 1995. Incident cardiovascular disease (CVD) (cardiovascular death, myocardial infarction, stroke, and transient ischaemic attack) and rates of non-CVD mortality were assessed between 1995 and 2005. Subjects with incident CVD had higher levels of Lp-PLA2 activity (884 +/- 196 vs. 771 +/- 192 micromol/min/L, P , 0.001). Increased Lp-PLA2 activity was significantly related to incident CVD [age- and sex-adjusted hazard ratio (95%CI) 2.9 (1.6-5.5); third vs. first tertile group; P , 0.001] and with vascular mortality but not with non-CVD ...
https://read.qxmd.com/read/19019993/lipoprotein-associated-phospholipase-a2-activity-ferritin-levels-metabolic-syndrome-and-10-year-cardiovascular-and-non-cardiovascular-mortality-results-from-the-bruneck-study
Lipoprotein-associated Phospholipase Inhibition Regulates Retinal Vasopermeability During Experimental Diabetes | IOVS | ARVO...Lipoprotein-associated Phospholipase Inhibition Regulates Retinal Vasopermeability During Experimental Diabetes | IOVS | ARVO...
Purpose: : Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays a major role in macrophage infiltration, pro-inflammatory cytokine expression and adhesion molecule upregulation in macrovascular disease. Since diabetic macular edema (DME) is recognised to have an inflammation-linked aetiology it was hypothesized that inhibition of this enzyme could be protective against blood retinal barrier (BRB) breakdown. Methods: : Localization of Lp-PLA2 in human retina was analyzed by immunohistology. In parallel, brown Norwegian (BN) rats had diabetes induced using streptozotocin (65mg/Kg). After 4 weeks hyperglycemia, animals were treated for 4 weeks with either vehicle or SB435495 (a specific inhibitor of Lp-PLA2)(10mg/Kg/day) by intra-peritoneal injection. An additional group of hyperglycemic animals were maintained treatment free for 4 weeks prior to initiating the 4 wk treatment regimen. An age and sex-matched group of non-diabetic NDb) BN rats were used as controls. Following drug treatment, BRB ...
http://iovs.arvojournals.org/article.aspx?articleid=2359464
Lipoprotein-Associated Phospholipase A2 Test - Request A TestLipoprotein-Associated Phospholipase A2 Test - Request A Test
A Lipoprotein-associated phospholipase A2 test is used to assess risk for heart disease. Request A Tests convenient, affordable lab testing makes it easy to take charge of your own health.
https://requestatest.com/lipoprotein-associated-phospholipase-a2-testing
Kidney Function Decline in the Elderly: Impact of Lipoprotein-Associated Phospholipase A2 - FullText - American Journal of...Kidney Function Decline in the Elderly: Impact of Lipoprotein-Associated Phospholipase A2 - FullText - American Journal of...
|i|Background:|/i| Whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with kidney function decline has not been well studied. |i|Me
https://content.karger.com/Article/FullText/333045
Pafah1b3 - Platelet-activating factor acetylhydrolase IB subunit gamma - Mus musculus (Mouse) - Pafah1b3 gene & proteinPafah1b3 - Platelet-activating factor acetylhydrolase IB subunit gamma - Mus musculus (Mouse) - Pafah1b3 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/Q8CA83
Sequence Similarity - 1FXW: CRYSTAL STRUCTURE OF THE RECOMBINANT ALPHA1/ALPHA2 CATALYTIC HETERODIMER OF BOVINE BRAIN...Sequence Similarity - 1FXW: CRYSTAL STRUCTURE OF THE RECOMBINANT ALPHA1/ALPHA2 CATALYTIC HETERODIMER OF BOVINE BRAIN...
1FXW: Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib.
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1FXW&entity=1&seqid=90
Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2 | Arteriosclerosis, Thrombosis, and...Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2 | Arteriosclerosis, Thrombosis, and...
The present study compares for the first time the effect of 3 hypolipidemic drugs (ezetimibe, rosuvastatin, fenofibrate), which exert their action through different mechanisms, on plasma Lp-PLA2 activity and mass. All drugs reduce Lp-PLA2 activity and mass associated with the atherogenic apoB-containing lipoproteins. Furthermore, fenofibrate increases the specific activity of the enzyme associated with these lipoproteins and specifically that of the most atherogenic dense LDL-5 subfraction.. Fenofibrate reduces Lp-PLA2 activity and mass associated with apoB-containing lipoproteins, an effect that could be mainly attributed to the preferential reduction of the enzyme associated with LDL-5 particles,24 ie, those particles carrying the majority of LDL-associated enzyme.2,6 In accordance with our previously published results,24 the present study shows that the above reduction is attributed to the fenofibrate action to decrease sdLDL and to increase large buoyant LDL particles, which have a higher ...
http://atvb.ahajournals.org/content/27/10/2236
Xarelto | Evolution of NADPH Oxidase InhibitorsXarelto | Evolution of NADPH Oxidase Inhibitors
Lipoprotein-associated phospholipase A2 (Lp-PLA2), specifically Group VIIA PLA2, is an associate from the phospholipase A2 superfamily and is available mainly connected with LDL and HDL in individual plasma. apoproteins Xarelto in HDL, and also, residues 360C368 are just suffering from HDL.The full total results claim that apoA-I and phospholipid membranes play crucial roles in Lp-PLA2 localization to HDL. 14: 2032C2039. [PubMed] 20. Okamura K., Miura S., Zhang B., Uehara Y., Matsuo K., Kumagai K., Saku K.2007. Proportion of LDL- to HDL-associated platelet-activating aspect acetylhydrolase could be a marker of irritation in sufferers with paroxysmal atrial fibrillation. Circ. J.71: 214C219. [PubMed] 21. Tsimihodimos V., Karabina S. A., Tambaki A. P., Bairaktari E., Miltiadous G., Goudevenos J. A., Cariolou M. A., Chapman M. J., Tselepis A. D., Elisaf M. 2002. Changed distribution of platelet-activating aspect- acetylhydrolase activity between LDL and HDL being a function of the severe nature of ...
http://biobeds.info/tag/xarelto/
Abstract 14551: LpPLA2 Activity and Mass Are Distributed Across Subfractions of Both LDL and HDL, and Relate Differently to CHD...Abstract 14551: LpPLA2 Activity and Mass Are Distributed Across Subfractions of Both LDL and HDL, and Relate Differently to CHD...
Objective: The current assumption is that the majority of the pro-oxidant enzyme Lipoprotein-Associated Phospholipase A2 (LpPLA2) resides on LDL-C, however the actual distribution of LpPLA2 on lipoproteins is unknown. We sought to determine the distribution of LpPLA2 mass and activity on different lipoproteins and the association with progression of coronary artery calcification (CAC).. Methods: From the Coronary Artery Calcification in Type 1 Diabetics (CACTI) study, we chose men with type 1 diabetes (not on statins, HDL-C in the 95th percentile by diabetes status) with and without CAC progression and matched controls (n=45). Lipoproteins were separated by Fast Protein Liquid Chromatography (FPLC). Individual samples of total plasma and pooled subfractions of LDL and HDL underwent LpPLA2 mass (PLAC) assays to measure accessible LpPLA2 mass on the surface of lipoprotein particles and activity (CAM) assays to measure total LpPLA2 activity dissociating from lipoprotein particles under denaturing ...
http://circ.ahajournals.org/content/122/Suppl_21/A14551
Relationship between plasma phospholipase A2 concentrations and lipoprotein subfractions in patients with stable coronary...Relationship between plasma phospholipase A2 concentrations and lipoprotein subfractions in patients with stable coronary...
BACKGROUND: Both increased lipoprotein-associated phospholipase A2 (Lp-PLA2) concentrations and atherogenic lipoprotein subfractions have been shown to reflect unfavourable cardiovascular risk. However, the correlation between Lp-PLA2 and lipoprotein subfractions in patients with coronary artery disease (CAD) has not been assessed yet.. METHODS: A total of 324 consecutive subjects who were not treated with lipid-lowering drugs were enrolled (angiographically proven CAD: n = 253; non-CAD: n = 71). Plasma Lp-PLA2 concentrations were measured using ELISA. The low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions were determined by Lipoprint System.. RESULTS: Plasma Lp-PLA2 concentrations were higher in patients with CAD compared with those without CAD (153.61 ± 78.73 vs. 131.41 ± 65.49 ng/ml, p = 0.028). The univariable correlation analysis revealed that Lp-PLA2 concentrations were positively correlated with the cholesterol concentrations of each LDL subfractions and the ...
https://read.qxmd.com/read/25934512/relationship-between-plasma-phospholipase-a2-concentrations-and-lipoprotein-subfractions-in-patients-with-stable-coronary-artery-disease
OriGene - PAFAH1B2 (NM 002572) Human ORF cDNA CloneOriGene - PAFAH1B2 (NM 002572) Human ORF cDNA Clone
PAFAH1B2 - PAFAH1B2 (GFP-tagged) - Human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) (PAFAH1B2), transcript variant 1 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/Human_ORF_Clone/RG201313.aspx
OriGene - Pafah1b2 (NM 008775) cDNA CloneOriGene - Pafah1b2 (NM 008775) cDNA Clone
Pafah1b2 - Pafah1b2 (untagged) - Mouse platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 (Pafah1b2), (10ug) available for purchase from OriGene - Your Gene Company.
http://www.origene.com/Mouse_cDNA/MC202049.aspx
Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans - Full Text View -...Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Progenitor Cells and Coronary Atherosclerosis in Humans - Full Text View -...
The main goal of AIM III is to assess and quantify the effect of long-term administration of darapladib 160 mg once a day, a selective, reversible, orally active inhibitor of plasma and vascular Lp-PLA2, on coronary endothelial function, progression of coronary atherosclerosis as determined by intravascular ultrasound (IVUS), and atherosclerosis in patients with early atherosclerosis. Patients with evidence of coronary endothelial dysfunction, as determined by intracoronary administration of acetylcholine during angiography and IVUS, will be followed for 6 months during once daily dosing of darapladib. Coronary endothelial function is determined by the changes in coronary artery diameter and coronary blood flow response to the intracoronary administration of acetylcholine and adenosine. The patients will be followed in clinic 6 months. They will have follow-up angiography, assessment of endothelial function, and IVUS during the six month visit ...
https://clinicaltrials.gov/ct2/show/NCT01067339?term=Cardiac+Catheterization&recr=Open&fund=01&rank=8
High-Sensitivity C-Reactive Protein and Lipoprotein-Associated Phospholipase A2 Stability Before and After Stroke and...High-Sensitivity C-Reactive Protein and Lipoprotein-Associated Phospholipase A2 Stability Before and After Stroke and...
Inflammation is increasingly recognized to play an important role in atherosclerosis and stroke.1,15 Macrophages, cytokines, and leukocyte adhesion molecules contribute to vascular injury, endothelial dysfunction, plaque formation, plaque rupture, and coagulopathy.16 Because of this, serum levels of inflammatory biomarkers such as hsCRP, an acute phase protein, have been used as nonspecific measures of vascular inflammation. Lp-PLA2 is an enzyme derived from leukocytes, particularly macrophages, that is involved in metabolism of LDL to the proinflammatory mediators lysophosphatidylcholine and oxidized fatty acids.3,11 Lysophosphatidylcholine increases expression of vascular adhesion molecules, upregulates cytokines and CD40 ligand, and stimulates macrophage proliferation.. Our findings provide evidence that hsCRP and LpPLA2 activity levels are stable when repeated annually. Our findings are similar to findings of stability for hsCRP from other populations.17,18 In one study among patients with ...
http://stroke.ahajournals.org/content/40/10/3233
Lipoprotein-Associated Phospholipase A2 Is an Independent Predictor of Incident Coronary Heart Disease in an Apparently Healthy...Lipoprotein-Associated Phospholipase A2 Is an Independent Predictor of Incident Coronary Heart Disease in an Apparently Healthy...
In the present study of older community-dwelling individuals, Lp-PLA2 levels were significantly higher in those who developed CHD compared with those who did not. Associations between Lp-PLA2 and LDL, HDL, total cholesterol, and triglycerides were especially strong, and the magnitude of the correlations was in good agreement with previous studies (7,19). Despite these associations, Lp-PLA2 remained a strong and independent predictor of fatal and nonfatal CHD events, over and above these and other traditional risk factors. Thus, Lp-PLA2 added information to lipid and lipoprotein prediction of future CHD and may identify subpopulations at risk for CHD who would not be identified otherwise.. A similar independent association of Lp-PLA2 with CHD risk was reported in the younger participants from the WOSCOPS (5) and ARIC (7,19) studies and in a nested case-control study from the Rotterdam study (9). We now confirm these results for the first time in a cohort of apparently healthy older men and women ...
http://www.onlinejacc.org/content/51/9/913
Circulating Levels of Secretory- and Lipoprotein-Associated Phospholipase A2 Activities: Relation to Atherosclerotic Plaques...Circulating Levels of Secretory- and Lipoprotein-Associated Phospholipase A2 Activities: Relation to Atherosclerotic Plaques...
sPLA2 [odds ratio 1.23 for 1 standard deviation (SD) increase, p = 0.007], but not Lp-PLA2 (p = 0.26), activity was related to carotid atherosclerosis and to the amount of stenosis by WBMRA (p = 0.006) following adjustment for multiple risk factors. sPLA2 [hazard ratio (HR) 1.45 for 1 SD increase, p = 0.001], but not Lp-PLA2 (HR, 0.95; p = 0.55), activity was a significant risk factor for all-cause mortality during 7.0 years follow-up after adjustment for other risk factors. In a sample of 1,029 post-MI patients, sPLA2 (adjusted HR 1.32 for 1 unit increase, p = 0.036), but not Lp-PLA2 (HR, 1.03; p = 0.90), activity predicted death or recurrent MI during 1-year follow-up.. ...
http://www.acc.org/latest-in-cardiology/journal-scans/2012/06/26/17/31/circulating-levels-of-secretory-and-lipoprotein-associated-phospholipase-a2
Lipoprotein-Associated Phospholipase A2 - Gundersen Health System - La Crosse, Wisconsin
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
http://healthinfo.gundersenhealth.org/RelatedItems/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
https://healthlibrary.vanderbilthealth.com/Conditions/Neuroscience/Tools/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
http://healthlibrary.munsonhealthcare.org/RelatedItems/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
https://healthinfo.coxhealth.com/RelatedItems/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
http://education.brmc.com/Library/TestsProcedures/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2 - INTEGRIS OK
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
http://healthlibrary.integrisok.com/YourFamily/Men/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
http://shine.methodisthealthsystem.org/RelatedItems/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
http://betterhealth.saintpetershcs.com/Library/DiseasesConditions/Pediatric/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
https://healthlibrary.wvumedicine.org/YourFamily/Women/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2Lipoprotein-Associated Phospholipase A2
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
https://shine.methodisthealthsystem.org/YourFamily/Women/167,lipoprotein_phospholipase_a2
Lipoprotein-Associated Phospholipase A2 Mass Level Is Increased in Elderly Subjects with Type 2 Diabetes MellitusLipoprotein-Associated Phospholipase A2 Mass Level Is Increased in Elderly Subjects with Type 2 Diabetes Mellitus
Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.
https://www.hindawi.com/journals/jdr/2014/278063/ref/
Lipoprotein-Associated Phospholipase A2 and Prognosis After Myocardial Infarction in the Community | Arteriosclerosis,...Lipoprotein-Associated Phospholipase A2 and Prognosis After Myocardial Infarction in the Community | Arteriosclerosis,...
Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
http://atvb.ahajournals.org/content/early/2006/08/10/01.ATV.0000240406.89440.0c
Lipoprotein-associated phospholipase A2 (Lp‑PLA<sub>2</sub>) - DiaSys Diagnostic...Lipoprotein-associated phospholipase A2 (Lp‑PLA<sub>2</sub>) - DiaSys Diagnostic...
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary. For diagnostic purposes, the results should always be assessed with the patients medical history, clinical examinations and other findings ...
https://www.diasys-diagnostics.com/service-area/support/reference-ranges/analyte/lipoprotein-associated-phospholipase-a2-lp-pla2/analyte.show
Human lipoprotein-associated phospholipase A2 , Lp-PLA2 ELISA Kit
Create a standard curve by reducing the data using computer software capable of generating a four parameter logistic (4-PL) curve-fit. As an alternative, construct a standard curve by plotting the mean absorbance for each standard on the x-axis against the concentration on the y-axis and draw a best fit curve through the points on the graph. The data may be linearized by plotting the log of the PLA2G7 concentrations versus the log of the O.D. and the best fit line can be determined by regression analysis. This procedure will produce an adequate but less precise fit of the data ...
http://www.egfie.com/product/CSB-E08319h
Lipoprotein-Associated Phospholipase A2 Activity, Serum (PLACA) Test Sheet - InsightsLipoprotein-Associated Phospholipase A2 Activity, Serum (PLACA) Test Sheet - Insights
Alyssa Frank is a Marketing Associate at Mayo Medical Laboratories. She supports marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015 ...
https://news.mayomedicallaboratories.com/2015/08/01/lipoprotein-associated-phospholipase-a2-activity-serum-placa-test-sheet/
ivd-test-reagent-kits-immunoassay-lipoprotein-associated-enzyme-phospholipase-a2
Definition : Immunoassay reagents intended to perform quantitative analyses of body fluids (typically plasma or serum) to determine the level of the lipoprotein-associated enzyme phospholipase A2 (Lp-PLA2). These tests are usually based on turbidimetric or ELISA tests that use specific antibodies to identify the level of (Lp-PLA2). They may be used as an aid to assess vascular inflammation and the risk for coronary heart disease and ischemic stroke associated with atherosclerosis.. Entry Terms : Lipoprotein-Associated Phospholipase A2 Determination Reagents , Lp-PLA2 Determination Reagents , PLAC Test ELISA Kits , PLAC Test Reagent Kits. UMDC code : 32900 ...
http://productguide.optometricmanagement.com/specialities/term/ivd-test-reagent-kits-immunoassay-lipoprotein-associated-enzyme-phospholipase-a2/35170?op=companies&key=ajax&per_page=
Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The...Genetic variants and haplotypes of lipoprotein associated phospholipase A2 and their influence on cardiovascular disease (The...
Summary There is increasing evidence that lipoprotein-associated phospholipase A2 (LpPLA2) is associated with cardiovascular disease. However, it is still unclear whether LpPLA2 is simply a marker or has a causal role as either a pro- or anti-atherogenic factor. We analyzed the association of five...
https://insights.ovid.com/thrombosis-haemostasis/jthrh/2009/01/000/genetic-variants-haplotypes-lipoprotein-associated/7/00149457
Functional Consequences of Mutations and Polymorphisms in the Coding Region of the PAF Acetylhydrolase (PAF-AH) GeneFunctional Consequences of Mutations and Polymorphisms in the Coding Region of the PAF Acetylhydrolase (PAF-AH) Gene
Academic Journals Database is a universal index of periodical literature covering basic research from all fields of knowledge, and is particularly strong in medical research, humanities and social sciences. Full-text from most of the articles is available. Academic Journals Database contains complete bibliographic citations, precise indexing, and informative abstracts for papers from a wide range of periodicals.
http://journaldatabase.info/articles/functional_consequences_mutations.html
Inhibiting inflammatory enzyme after heart attack does not reduce risk of subsequent event | EurekAlert! Science NewsInhibiting inflammatory enzyme after heart attack does not reduce risk of subsequent event | EurekAlert! Science News
In patients who experienced an acute coronary syndrome event -- such as heart attack or unstable angina -- use of the drug darapladib to inhibit the enzyme lipoprotein-associated phospholipase A2 -- believed to play a role in the development of atherosclerosis -- did not reduce the risk of recurrent major coronary events, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the European Society of Cardiology Congress.
https://www.eurekalert.org/pub_releases/2014-08/tjnj-iie082714.php
can manifest efectos proscar alopecia Mosby- Year
Пппп Page 20 пппп12 Ch. Efectos proscar alopecia Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in sperm- atogenesis. Efec tos Ideally, all children with CNS tumours undergoing aloecia.
http://anigroup.ru/generic-ed-drugs/efectos-proscar-alopecia.html
Dental News Report: Gum disease = risk for cardiovascular disease
In this study, 421 individuals who were blood related to and/or living with a person recently hospitalized due to cardiovascular disease were screened for traditional cardiovascular risk factors (such as elevated blood pressure and abnormal cholesterol levels), inflammatory markers associated with disease risk (high-sensitivity c-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2)). They were also asked standardized questions about their oral health status, including whether they had ever been diagnosed with periodontal (gum) disease, whether they had ever been treated for periodontal disease, whether they used partial or complete removable dentures, and the date of their last teeth cleaning. The oral health history was then correlated with standard markers of inflammation ...
http://dentalnewsreport.blogspot.com/2008/11/gum-disease-risk-for-cardiovascular.html
Corrigendum to Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported...
TY - JOUR. T1 - Corrigendum to Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population. [Atherosclerosis 246 (March 2016) 141-147](S0021915015302562)(10.1016/j.atherosclerosis.2015.12.027). AU - the ACCESS and SESSA Research Groups. AU - Ueshima, Hirotsugu. AU - Kadowaki, Takashi. AU - Hisamatsu, Takashi. AU - Fujiyoshi, Akira. AU - Miura, Katsuyuki. AU - Ohkubo, Takayoshi. AU - Sekikawa, Akira. AU - Kadota, Aya. AU - Kadowaki, Sayaka. AU - Nakamura, Yasuyuki. AU - Miyagawa, Naoko. AU - Okamura, Tomonori. AU - Kita, Yoshikuni. AU - Takashima, Naoyuki. AU - Kashiwagi, Atsunori. AU - Maegawa, Hiroshi. AU - Horie, Minoru. AU - Yamamoto, Takashi. AU - Kimura, Takeshi. AU - Kita, Toru. N1 - Publisher Copyright: © 2015 Elsevier B.V.. PY - 2018/11. Y1 - 2018/11. N2 - The authors of the above paper have realized that an error has occurred in the number of eligible individuals ...
https://okayama.pure.elsevier.com/en/publications/corrigendum-to-lipoprotein-associated-phospholipase-a2-is-related
Lipoprotein-associated Phospholipase A2 and Serum Lipid Levels in Supjects with Chronic Periodontitis and HyperlipidemiaLipoprotein-associated Phospholipase A2 and Serum Lipid Levels in Supjects with Chronic Periodontitis and Hyperlipidemia
Methods: Forty chronic periodontitis (CP) subjects with hyperlipidaemia (CP/HPL group), 40 systemically healthy CP subjects (CP group) and 20 systemically and periodontally healthy subjects (control group) were enrolled. The clinical periodontal parameters, the serum concentrations of Lp-PLA2, lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and white blood cell (WBC) counts were determined and compared between different groups. Linear regression analysis was performed to identify the contributing factors of Lp-PLA2 ...
http://www.quintpub.com/journals/cjdr/abstract.php?iss2_id=1099&article_id=12852&article=5&title=Lipoprotein-associated%20Phospholipase%20A2%20and%20Serum%20Lipid%20Levels%20in%20Supjects%20with%20Chronic%20Periodontitis%20and%20Hyperlipidemia
Lipoprotein-Associated Phospholipase A2 - AHealthyMe - Blue Cross Blue Shield of Massachusetts
This test looks for a specific lipoprotein, Lp-PLA2, in your blood. The test is used to help predict your risk for cardiovascular disease and stroke.
http://www.ahealthyme.com/Conditions/Neuroscience/167,lipoprotein_phospholipase_a2
Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. | StrokeEvidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. | Stroke
Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on cerebrovascular and neural elements. While several investigators have reported attenuation of ischemic damage after treatment with antagonists of platelet-activating factor, no study has proved endogenous production of platelet-activating factor in ischemia of the central nervous system. We hypothesized that endogenous production of platelet-activating factor participates in the early pathologic manifestations of deteriorating stroke. In 12 rabbits, we found tissue levels of platelet-activating factor measured by the release of serotonin from washed platelets to be elevated by approximately 20-fold in spinal cord injured by 25 minutes of ischemia and 2 hours of reperfusion (2.80 +/- 0.98 ng/g) compared with that in normal spinal cord (0.15 +/- 0.06 ng/g, p less than 0.01). Given during ischemia to seven rabbits, 10 mg/kg i.p. of a highly selective and potent antagonist of platelet-activating factor (BN ...
http://stroke.ahajournals.org/content/21/10/1452
Lp-PLA2 and Coronary Atherosclerosis in Humans - Full Text View - ClinicalTrials.govLp-PLA2 and Coronary Atherosclerosis in Humans - Full Text View - ClinicalTrials.gov
The majority of the acute coronary events are caused by coronary artery segments with minimal luminal disease, but with potentially significant vascular wall inflammation and oxidative stress leading to plaque vulnerability. It has become apparent that an initial injury at the endothelial surface, is the primary site of the mechanisms involved and a role for vascular inflammation and the interaction with oxidative stress continues to emerge. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel biomarker for vascular wall inflammation that circulates in the blood bound to both low density (LDL) and high density (HDL) lipoprotein and promotes vascular inflammation. Circulating levels of Lp-PLA2 mass and activity are an independent risk factor for cardiovascular events. Recent studies, demonstrating that Lp-PLA2 is also associated with coronary endothelial dysfunction. However, the relationship between Lp-PLA2 and early atherosclerotic changes in the coronary arteries, and the contribution ...
https://clinicaltrials.gov/ct2/show/NCT01557088?term=Atherosclerosis+OR+arteriosclerosis+OR+hardening+of+the+arteries&recr=Open&fund=01&rank=13
Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA) | Lipids in Health and Disease ...Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA) | Lipids in Health and Disease ...
The omega-3 fatty acid eicosapentaenoic acid (EPA) has multiple actions potentially conferring cardiovascular benefit, including lowering serum triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) levels and potentially reducing key steps in atherogenesis. Dietary supplements are a common source of omega-3 fatty acids in the US, but virtually all contain docosahexaenoic acid (DHA) in addition to EPA, and lipid effects differ between DHA and EPA. Contrary to popular belief, no over-the-counter omega-3 products are available in the US, only prescription products and dietary supplements. Among the US prescription omega-3 products, only one contains EPA exclusively (Vascepa); another closely related prescription omega-3 product also contains highly purified EPA, but is approved only in Japan and is provided in different capsule sizes. These high-purity EPA products do not raise low-density lipoprotein cholesterol (LDL-C) levels, even in patients with TG levels |500 mg/dL, in contrast
https://lipidworld.biomedcentral.com/articles/10.1186/s12944-017-0415-8
PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function.PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function.
Recent studies showed that the phospholipase subunits of Platelet Activating Factor Acetylhydrolase (PAFAH) Ib, α1 and α2 partially localize to the Golgi complex and regulate its structure and function. Using siRNA knockdown of individual subunits, we find that α1 and α2 perform overlapping and unique roles in regulating Golgi morphology, assembly, and secretory cargo trafficking. Knockdown of either α1 or α2 reduced secretion of soluble proteins, but neither single knockdown reduced secretion to the same degree as knockdown of both. Knockdown of α1 or α2 inhibited reassembly of an intact Golgi complex to the same extent as knockdown of both. Transport of VSV-G was slowed but at different steps in the secretory pathway: reduction of α1 slowed trans Golgi network to plasma membrane transport, whereas α2 loss reduced endoplasmic reticulum to Golgi trafficking. Similarly, knockdown of either subunit alone disrupted the Golgi complex but with markedly different morphologies. Finally, ...
http://temp.crm.ed.ac.uk/print/1231
platelet-activating factorplatelet-activating factor
What is the definition of platelet-activating factor? What is the meaning of platelet-activating factor? How do you use platelet-activating factor in a sentence? What are synonyms for platelet-activating factor?
https://www.lexico.com/en/definition/platelet-activating_factor
Plus itPlus it
Proper development of the mammalian cerebral cortex relies on the integrated control of neurogenesis and neuronal migration. Proliferation of neuronal progenitor cells during early stages of brain development is critical to expand the progenitor pool at the ventricular surface and later mitotic divisions result in the generation of postmitotic neural precursors, which then migrate to the cortical plate (Gupta et al., 2002; Götz and Huttner, 2005). Defective neurogenesis or neuronal migration leads to brain malformations, and are often associated with different forms of mental retardation or cognitive disabilities and severe epilepsy Guerrini et al., 2008). For example, classical lissencephaly (or smooth brain) is due to a reduced number or absence of gyri and sulci of the cortical surface, resulting in severe mental retardation, seizures and early death (Kato and Dobyns, 2003). Mutations in two genes, LIS1 (Reiner et al., 1993; Lo Nigro et al., 1997) and DCX (Gleeson et al., 1998; des Portes ...
http://www.jneurosci.org/content/30/8/3002
State of the art paper Low-density lipoprotein, its susceptibility to oxidation and the role of lipoprotein-associated...State of the art paper Low-density lipoprotein, its susceptibility to oxidation and the role of lipoprotein-associated...
An increased level of low-density lipoprotein (LDL) is a very well established risk factor of coronary artery disease (CAD). Unoxidized LDL is an inert transport vehicle of cholesterol and other lipids in the body and is thought to be atherogenic. Recently it has been appreciated that oxidized...
https://www.archivesofmedicalscience.com/State-of-the-art-paper-Low-density-lipoprotein-its-susceptibility-to-oxidation-and,52794,0,2.html
Miller-Dieker Syndrome | SpringerLinkMiller-Dieker Syndrome | SpringerLink
In 1963, Miller reported two siblings with a specific pattern of malformations in which lissencephaly was a key feature. Later in 1969, Dieker et al. described a similar condition. Jones et al. in ...
https://link.springer.com/referenceworkentry/10.1007/978-1-4614-6430-3_157-2
Tissue expression of PAFAH1B1 - Staining in lung - The Human Protein AtlasTissue expression of PAFAH1B1 - Staining in lung - The Human Protein Atlas
Expression of PAFAH1B1 (LIS1, MDCR, MDS, NudF, PAFAH) in lung tissue. Antibody staining with HPA020036 and CAB004489 in immunohistochemistry.
http://www.proteinatlas.org/ENSG00000007168-PAFAH1B1/tissue/lung
PAFAH1B1 (Human) Recombinant Protein (P01) - (H00005048-P01) - Products - Abnova
Human PAFAH1B1 full-length ORF ( AAH64638.1, 1 a.a. - 410 a.a.) recombinant protein with GST-tag at N-terminal. (H00005048-P01) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00005048-P01
Tissue expression of PAFAH1B3 - Summary - The Human Protein AtlasTissue expression of PAFAH1B3 - Summary - The Human Protein Atlas
Summary of PAFAH1B3 () expression in human tissue. Cytoplasmic and membranous expression in several tissues, including a subsets of immune cells.
http://www.proteinatlas.org/ENSG00000079462-PAFAH1B3/tissue/vulva%252Fanal+skin
NKFI-EPR:Ischaemiás-reperfusiós károsodások funkcionális és strukturális változásainak kivédése különböző (máj, vékonybél,...NKFI-EPR:Ischaemiás-reperfusiós károsodások funkcionális és strukturális változásainak kivédése különböző (máj, vékonybél,...
Ischaemiás-reperfusiós károsodások funkcionális és strukturális változásainak kivédése különböző (máj, vékonybél, szabad lebeny, amputatum) experimentalis sebészi modelleken
http://nyilvanos.otka-palyazat.hu/index.php?menuid=930&num=67779
A becs lt n triumbevitel sszef gg se a sz v anat miai s funkcion lis k rosod s val. A HyperGEN tanulm ny eredm nyei
Jelenleg sem egy rtelm , hogy mi tekinthet a n triumbevitel optim lis szintj nek. A k zlem nyben azt vizsg lt k, vajon a bal kamra longitudin lis deform l d sa (longitudinal strain - LS), circumferenci lis deform l d sa s az e′ sebess g alapj n van-e a becs lt n triumbevitelnek (e...
http://hypertension.hu/hirek.aspx?nid=86140&archiv=1
Az intracraniális hemodinamika és a Willis-kör morfológiai jelentősége a carotis rekonstrukciós műtéteinélAz intracraniális hemodinamika és a Willis-kör morfológiai jelentősége a carotis rekonstrukciós műtéteinél
A Willis-körök morfológiai analízisét végeztük nem stroke-os betegpopulációban. A száztíz eltávolított Willis-körből huszonöt esetben (22,7%) találtunk inkomplett kört, vagyis olyan rendszert, mikor egy vagy több ér hiánya, vagy eltérő lefutása miatt az ív nem zárult be. A teljesnek Willis-köröknek leírtuk az anatómiai variációit, ahol valamelyik ér rendellenes helyen szájazott vagy duplikációk voltak fellelhetőek. Ezek a variációk nyilvánvalóan nem befolyásolták a kollaterális kapacitást, minthogy mindegyik esetben teljes körről volt szó. Megállapítottuk az egyes érszegmentumok átlagos átmérőit, hosszát valamint összehasonlítottuk a páros erek esetén a két oldal átmérőit is. Matematikai keringés-élettani modellt alkalmaztunk a Willis-köri kollaterálisok funkcionális képességének vizsgálatára. A prémortem készült színkódolt transcranialis Doppler vizsgálatok eredményei alapján osztályoztuk a Willis-köri ...
https://dea.lib.unideb.hu/dea/handle/2437/181237
Lis (Lactulose) LisapharmaLis (Lactulose) Lisapharma
Lis information about active ingredients, pharmaceutical forms and doses by Lisapharma, Lis indications, usages and related health products lists
http://drugs-about.com/drugs-l/lis.html
Panasonic NV-GS500 tip. 3CCD-s digit lis DV kamera, doboz ban elad ! - Sz kesfeh rv r, Fej rPanasonic NV-GS500 tip. 3CCD-s digit lis DV kamera, doboz ban elad ! - Sz kesfeh rv r, Fej r
Panasonic NV-GS500 tip. 3CCD-s digit lis DV kamera, doboz ban elad !: Panasonic NV-GS500 tip. 3CCD-s digit lis DV kamera, doboz ban, gy ri tartoz kain...
https://www.jofogas.hu/fejer/Panasonic_NV_GS500_tip__3CCD_s_digitalis_DV_kamera__dobozaban_elado__120498734.htm
QUICK FIX BLISTER Univerzális pillanatragasztó - cianoakriláQUICK FIX BLISTER Univerzális pillanatragasztó - cianoakrilá
QUICK FIX BLISTER Univerzális pillanatragasztó - cianoakrilát 3 g, .cs95E872D0{text-align:left;text-indent:0pt;margin:0pt 0pt 0pt 0pt} .cs1B16EEB5{color:#
https://esdshop.hu/en/spd/A-30710/QUICK-FIX-BLISTER-Univerzalis-pillanatragaszto-cia
Вторая вакцина с проблемами, и прочее: chuka lis - LiveJournal
Вакцина от Джонсон и Джонсон, пока приостановила 3 стадию клинических испытаний в США- у волонтера с прививкой развилось некоторое неожиданное и необъяснимое заболевание. Подробностей не выдают. J ohnson Johnson said Monday that it has paused further dosing in its trial while the…
https://chuka-lis.livejournal.com/428784.html?view=comments
Topical - Page 5 of 5 - MylabTopical - Page 5 of 5 - Mylab
Jos jokin jäi askarruttamaan tai haluaisit saada lisätietoja Mylabilla työskentelemisestä otathan yhteyttä meidän HR-tiimiimme ja jutellaan lisää. ...
https://www.mylab.fi/en/topical/page/5/
Reflux-betegség | Blausen MedicalReflux-betegség | Blausen Medical
A gasztrointsztinális, más néven gyomorbél-traktust a szájüreg, a garat, a nyelőcső, a gyomor, valamint a vékony- és vastagbél alkotja. A gyomorbél-tr...
https://blausen.com/hu/video/reflux-betegseg/
Avatar-kauppaAvatar-kauppa
Tämä sivusto käyttää evästeitä analytiikkaan sekä mukautetun sisällön ja mainosten näyttämiseen. Jatkamalla sivuston käyttöä hyväksyt tällaisen käytön. Lisätietoja ...
http://marketplace.xbox.com/fi-FI/AvatarMarketplace?pagesize=56&xr=shellnav&Brand=14080
Pälkäne, PirkanmaaPälkäne, Pirkanmaa
Vuokramökki Pitkälahdentie 127, 36450 Salmentaka, alk. 550 € euroa / viikko. Klikkaa tästä kuvat ja lisätiedot ja tarkasta mökin saatavuus.
https://www.nettimokki.com/en/palkane/1691
Inari, LappiInari, Lappi
Vuokramökki Luppotie 4, 99830 Saariselkä, alk. 596 € euroa / viikko. Klikkaa tästä kuvat ja lisätiedot ja tarkasta mökin saatavuus.
https://www.nettimokki.com/en/inari/5836
List of MeSH codes (D08)List of MeSH codes (D08)
... naphthol as d esterase MeSH D08.811.277.352.100.680 - phospholipases MeSH D08.811.277.352.100.680.510 - lysophospholipase MeSH ... cholesterol esterase MeSH D08.811.277.352.100.170 - cholinesterases MeSH D08.811.277.352.100.170.176 - acetylcholinesterase ... endo-1,4-beta xylanases MeSH D08.811.277.450.950.500 - xylan endo-1,3-beta-xylosidase MeSH D08.811.277.656.149 - atp-dependent ... glucan 1,4-beta-glucosidase MeSH D08.811.277.450.420.200.600 - glucan endo-1,3-beta-d-glucosidase MeSH D08.811.277.450.420.375 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
1-alkyl-2-acetylglycerophosphocholine esterase1-alkyl-2-acetylglycerophosphocholine esterase
256 (1): 175-8. PMID 7451433. PAF+acetylhydrolase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.1 ... The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction 1-alkyl-2-acetyl-sn-glycero-3- ... The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common ... Blank ML, Lee T, Fitzgerald V, Snyder F (1981). "A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a ...
https://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase
List of EC numbers (EC 3)List of EC numbers (EC 3)
... apo-salmochelin esterase * EC 3.1.1.108: iron(III)-enterobactin esterase * EC 3.1.1.109: iron(III)-salmochelin esterase * EC ... acetylxylan esterase EC 3.1.1.73: feruloyl esterase EC 3.1.1.74: cutinase EC 3.1.1.75: poly(3-hydroxybutyrate) depolymerase EC ... polyneuridine-aldehyde esterase EC 3.1.1.79: hormone-sensitive lipase EC 3.1.1.80: acetylajmaline esterase EC 3.1.1.81: quorum- ... methyl ester esterase EC 3.1.1.86: rhamnogalacturonan acetylesterase EC 3.1.1.87: fumonisin B1 esterase EC 3.1.1.88: pyrethroid ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_3)
Code System ConceptCode System Concept
1-Alkyl-2-acetylglycerophosphocholine esterase Current Synonym true false 3040606019 Lipoprotein associated phospholipase A2 ... 1-alkyl-2-acetylglycerophosphocholine esterase (substance). Code System Preferred Concept Name. 1-alkyl-2- ... acetylglycerophosphocholine esterase (substance). Concept Status. Published. Concept Status Date. 09/01/2020. ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=112040006
Code System ConceptCode System Concept
Chloracetate esterase (substance) {259725001 , SNOMED-CT } Cholesterol esterase (substance) {50622004 , SNOMED-CT } Dornase ... Alpha-amino-acid esterase (substance) {50854006 , SNOMED-CT } Alpha-naphthyl acetate esterase (substance) {115330006 , SNOMED- ... Esterase (substance) {130196001 , SNOMED-CT } Parent/Child (Relationship Type) 1-alkyl-2-acetylglycerophosphocholine esterase ( ... Retinyl-palmitate esterase (substance) {24307008 , SNOMED-CT } Streptodornase (substance) {123685004 , SNOMED-CT } Tannase ( ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=130196001
Bond University Nutrition and Dietetics Research Group - Research Outputs - Bond University Research PortalBond University Nutrition and Dietetics Research Group - Research Outputs - Bond University Research Portal
English, C. J., Mayr, H. L., Lohning, A. E. & Reidlinger, D. P., 1 Jun 2022, In: Nutrition Reviews. 80, 6, p. 1371-1391 21 p., ... Murray, E. M., Hickman, I. J., Isbel, N. M. & Campbell, K. L., Sep 2015, In: Nephrology. 20, S3, p. 58-58 1 p., 150.. Research ... Crichton, M., Marx, W., Lohning, A. E., Isenring, E. & Marshall, S., Aug 2020, In: Nutrition and Dietetics. 77, S1, p. 29-27 2 ... Desbrow, B., Irwin, C., Delang, N. & Cox, G. R., Jul 2020, In: Medicine and Science in Sports and Exercise. 52, 7S, p. 170 1 p. ...
https://research.bond.edu.au/en/organisations/bond-university-nutrition-and-dietetics-research-group/publications/?ordering=title&descending=false&page=6
ENZYME: 3.-.-.ENZYME: 3.-.-.
... apo-salmochelin esterase 3.1.1.108 iron(III) enterobactin esterase 3.1.1.109 iron(III) salmochelin esterase 3.1.1.110 xylono-1, ... acetylxylan esterase 3.1.1.73 feruloyl esterase 3.1.1.74 cutinase 3.1.1.75 poly(3-hydroxybutyrate) depolymerase 3.1.1.76 poly(3 ... methyl ester esterase 3.1.1.86 rhamnogalacturonan acetylesterase 3.1.1.87 fumonisin B1 esterase 3.1.1.88 pyrethroid hydrolase ... alpha-amino-acid esterase 3.1.1.44 4-methyloxaloacetate esterase 3.1.1.45 carboxymethylenebutenolidase 3.1.1.46 deoxylimonate A ...
https://enzyme.expasy.org/EC/3.-.-.-
SMART: Pfam domain PAF-AH p IISMART: Pfam domain PAF-AH p II
Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipase A2, and is involved in regulation of inflammation through the inactivation of platelet-activating factor and polar phospholipids [ (PUBMED:9645224) ]. ...
https://smart.embl.de/smart/do_annotation.pl?DOMAIN=Pfam:PAF-AH_p_II&START=47&END=122&E_VALUE=1e-27&TYPE=PFAM&BLAST=AAGSGHSKIPKGNGSYPVGCTDLMFGYGNESVFVRLYYPAQDQGRLDTVWIPNKEYFLGLSIFLGTPSIVGNILHL
Human PLA2G7/PAF-AH/Lp-PLA2 Antibody MAB51061-100: R&D SystemsHuman PLA2G7/PAF-AH/Lp-PLA2 Antibody MAB51061-100: R&D Systems
Secretory phopholipase A2 is an enzyme that hydrolyses the Sn-2 ester bond of phospholipids, generating free fatty acids and ... 1 month, 2 to 8 °C under sterile conditions after reconstitution.. *6 months, -20 to -70 °C under sterile conditions after ... Human PLA2G7/PAF‑AH/Lp‑PLA2 ELISA Standard Curve. Recombinant Human PLA2G7/PAF-AH/Lp-PLA2 protein was serially diluted 2-fold ... In contrast to other classical sPLA2s, PLA2G‑VII has poor specificity toward Sn-2 long chain fatty acids, unless heavily ...
https://www.rndsystems.com/products/human-pla2g7-paf-ah-lp-pla2-antibody-973005_mab51061
LongText Report for: 5ye9-pdbLongText Report for: 5ye9-pdb
6 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE,2-ACETYL-1- COMPND 7 ALKYLGLYCEROPHOSPHOCHOLINE ESTERASE,GROUP-VIIA PHOSPHOLIPASE A2, ... 2 AA110 VAL A 65 PHE A 72 1 N VAL A 65 O ASN A 133 SHEET 3 AA110 THR A 79 PRO A 86 -1 O TYR A 85 N GLY A 66 SHEET 4 AA110 ILE A ... 2 AA410 VAL B 65 PHE B 72 1 N VAL B 65 O ASN B 133 SHEET 3 AA410 THR B 79 PRO B 86 -1 O TYR B 85 N GLY B 66 SHEET 4 AA410 ILE B ... 1 O ILE A 417 N THR A 345 SHEET 1 AA2 2 THR A 95 LEU A 96 0 SHEET 2 AA2 2 THR A 129 THR A 130 -1 O THR A 130 N THR A 95 SHEET 1 ...
https://bioweb.supagro.inrae.fr/ESTHER/tree?name=5YE9-pdb&class=LongText
Department of Medicine - Research output - Creighton UniversityDepartment of Medicine - Research output - Creighton University
Gupta, P., Giehler, K., Walters, R. W., Meyerink, K. & Modrykamien, A. M., Feb 1 2014, In: Respiratory Care. 59, 2, p. 170-177 ... Gallagher, J. C., Jindal, P. S. & Smith, L. M., Jan 1 2014, In: Journal of Bone and Mineral Research. 29, 1, p. 173-181 9 p.. ... Tarasova, V. D., Trepp-Carrasco, A. G., Thompson, R., Recker, R. R., Chong, W. H., Collins, M. T. & Armas, L. A. G., Nov 1 2013 ... Heaney, R. P., Jan 2014, In: Nutrition Reviews. 72, 1, p. 48-54 7 p.. Research output: Contribution to journal › Article › peer ...
https://creighton.pure.elsevier.com/en/organisations/department-of-medicine/publications/?type=/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article&type=/dk/atira/pure/researchoutput/researchoutputtypes/contributiontoperiodical/article&ordering=publicationYearThenTitle&descending=false&page=28
Bond University Nutrition and Dietetics Research Group - Research Outputs - Bond University Research PortalBond University Nutrition and Dietetics Research Group - Research Outputs - Bond University Research Portal
Law, L., Kelly, J. T., Savill, H., Wallen, M. P., Hickman, I. J., Erku, D. & Mayr, H., 2 Feb 2022, (E-pub ahead of print) In: ... English, C. J., Mayr, H. L., Lohning, A. E. & Reidlinger, D. P., 1 Jun 2022, In: Nutrition Reviews. 80, 6, p. 1371-1391 21 p., ... Bailey, N. W., Bridgman, T. K., Marx, W. & Fitzgerald, P. B., 1 Dec 2016, In: Mindfulness. 7, 6, p. 1249-1255 7 p.. Research ... Crichton, M., Davidson, A. R., Innerarity, C., Marx, W., Lohning, A., Isenring, E. & Marshall, S., 1 Jun 2022, In: American ...
https://research.bond.edu.au/en/organisations/bond-university-nutrition-and-dietetics-research-group/publications/?ordering=type&descending=false&page=7
i5k - EOG8ZSCHKi5k - EOG8ZSCHK
Site designed and maintained by Gregg Thomas, 2017 , Some of the CSS used to design this site is from the Pure CSS project. , Banner image ...
https://i5k.gitlab.io/ArthroFam-fams/EOG8ZSCHK.html
GeishaGeisha
platelet-activating factor acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine ... esterase,LDL-PLA(2),LDL-associated phospholipase A2,PAF 2-acylhydrolase,PAF acetylhydrolase,phospholipase A2, group VII ( ...
http://geisha.arizona.edu/geisha/search.jsp?geisha_id=PLA2G7.UApcr
Gene locus Report for: mizye-a0a210q4j1Gene locus Report for: mizye-a0a210q4j1
2 UniProt : A0A210Q4J1, B1A9T4. 2 Interpro : A0A210Q4J1, B1A9T4. 2 Prodom : A0A210Q4J1, B1A9T4. 2 Pfam : A0A210Q4J1, B1A9T4. 2 ... Ref: Nat Ecol Evol, 1:120, 2017 : PubMed. Abstract. ESTHER: Wang_2017_Nat.Ecol.Evol_1_120. PubMedSearch: Wang 2017 Nat.Ecol. ... Evol 1 120. PubMedID: 28812685. Gene_locus related to this paper: mizye-a0a210qls6, mizye-a0a210qis3, mizye-a0a210qg00, mizye- ... ACHE : mizye-a0a210qls6Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis). Acetylcholinesterase PYE-5989.14.1 ...
https://bioweb.supagro.inrae.fr/ESTHER/gene_locus?name=mizye-a0a210q4j1&class=Gene_locus
3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase - BRENDA Enzyme Database3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase - BRENDA Enzyme Database
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine. + H2O. = 1-alkyl-sn-glycero-3-phosphocholine. + acetate. ... 3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase. This is an abbreviated version!. For detailed information about 1- ... More, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase, alkylacetyl-GPC:acetylhydrolase, deacetylase, 1-alkyl-2- ... 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, type I platelet-activating factor acetylhydrolase, plasma PAF ...
https://brenda-enzymes.org/all_enzymes.php?ecno=3.1.1.47&table=Temperature_Stability
A revision of the lissencephaly and Miller-Dieker syndrome critical regions in chromosome 17p13.3. | Profiles RNSA revision of the lissencephaly and Miller-Dieker syndrome critical regions in chromosome 17p13.3. | Profiles RNS
Chong SS, Pack SD, Roschke AV, Tanigami A, Carrozzo R, Smith AC, Dobyns WB, Ledbetter DH. A revision of the lissencephaly and Miller-Dieker syndrome critical regions in chromosome 17p13.3. Hum Mol Genet. 1997 Feb; 6(2):147-55 ...
https://profiles.uchicago.edu/profiles/display/4448321
Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32...Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32...
FINDINGS: Lp-PLA(2) activity and mass were associated with each other (r=0.51, 95% CI 0.47-0.56) and proatherogenic lipids. We ... INTERPRETATION: Lp-PLA(2) activity and mass each show continuous associations with risk of coronary heart disease, similar in ... RRs, adjusted for conventional risk factors, were: 1.10 (95% CI 1.05-1.16) with Lp-PLA(2) activity and 1.11 (1.07-1.16) with Lp ... RRs with Lp-PLA(2) did not differ significantly in people with and without initial stable vascular disease, apart from for ...
https://www.cardioscience.ox.ac.uk/publications/92402?1d903500-77a7-11ed-a56f-061ab7f93640
MMTBMMTB
3.1.1.59 juvenile-hormone esterase 3.1.1.72 acetylxylan esterase 3.1.1.73 feruloyl esterase - - - - - ... phthalate esterase 3.1.1.72 acetylxylan esterase 3.1.1.73 feruloyl esterase 3.1.1.74 cutinase 3.1.1.75 poly(3-hydroxybutyrate) ... 3.1.1.108 iron(III)-enterobactin esterase 3.1.1.13 sterol esterase 3.1.1.2 arylesterase 3.1.1.23 acylglycerol lipase 3.1.1.3 ... 2 1-octyne + 2 NADH + 2 H+ + 2 O2 <=> Octanoate + 7-octynoic_acid + 2 NAD+ + 2 H2O 1.14.15.3 alkane 1-monooxygenase - ...
https://metano.tu-bs.de/search/Octanoate =
Aileen P. McGinn - Publications - Albert Einstein College of MedicineAileen P. McGinn - Publications - Albert Einstein College of Medicine
Tanenbaum, E. J., Johnson, J. H., Jordan, E., Cottral, J., Tenore, C., Burton, W. B., McGinn, A. P. & Raff, A. C., Dec 1 2016, ... Hochfelder, C. G., McGinn, A. P., Mehta, V., Castellucci, E., Kabarriti, R. & Ow, T. J., Nov 1 2020, In: Laryngoscope. 130, 11 ... Hawks, R. M., McGinn, A. P., Bernstein, P. S. & Tobin, J. N., Aug 1 2018, In: Maternal and child health journal. 22, 8, p. 1103 ... Khan, U. I., McGinn, A. P., Isasi, C. R., Groisman-Perelstein, A., Diamantis, P. M., Ginsberg, M. & Wylie-Rosett, J., Jun 1 ...
https://einstein.pure.elsevier.com/en/persons/aileen-p-mcginn/publications/?type=/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) as a Marker of Coronary Heart Disease - Fingerprint - Universitas...Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) as a Marker of Coronary Heart Disease - Fingerprint - Universitas...
Dive into the research topics of 'Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) as a Marker of Coronary Heart Disease'. Together they form a unique fingerprint. ...
https://scholar.ui.ac.id/en/publications/lipoprotein-associated-phospholipase-a2-lp-pla2-as-a-marker-of-co/fingerprints/
US8454994B2 - Stable pharmaceutical composition and methods of using same - Google PatentsUS8454994B2 - Stable pharmaceutical composition and methods of using same - Google Patents
125000006724 (C1-C5) alkyl ester group Chemical group 0.000 description 1 * ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-ethylpyrrolidin-2-one ... 229940068917 Polyethylene Glycols Drugs 0.000 description 2 * 206010045261 Type IIa hyperlipidaemia Diseases 0.000 description ... 206010030113 Oedema Diseases 0.000 description 2 * 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 description ... 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 2 * 229920003171 Poly (ethylene oxide) Polymers 0.000 ...
https://patents.google.com/patent/US8454994/en
A pleiotropic QTL on 2p influences serum Lp-PLA<sub>2</sub> activity and LDL cholesterol concentration in a baboon model for...A pleiotropic QTL on 2p influences serum Lp-PLA<sub>2</sub> activity and LDL cholesterol concentration in a baboon model for...
Y1 - 2008/2. N2 - Lipoprotein-associated phospholipase A2 (Lp-PLA2), the major portion of which is bound to low-density ... 2, 02.2008, p. 667-673.. Research output: Contribution to journal › Article › peer-review ... The QTL-specific correlation between the traits (ρQ = 0.62) was significantly different from both zero and 1 (P[ρQ = 0] = 0.047 ... A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics ...
https://ohsu.pure.elsevier.com/en/publications/a-pleiotropic-qtl-on-2p-influences-serum-lp-plasub2sub-activity-a
Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk fartors, angiographic coronary...Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk fartors, angiographic coronary...
Y1 - 2005/1. N2 - Aims: We aimed to evaluate the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with coronary ... 2, 01.2005, p. 137-144.. Research output: Contribution to journal › Article › peer-review ... European heart journal, 26(2), 137-144. https://doi.org/10.1093/eurheartj/ehi010 ...
https://utsouthwestern.pure.elsevier.com/en/publications/association-of-lipoprotein-associated-phospholipase-a2-levels-wit
Clinical and molecular basis of classical lissencephaly: Mutations in the LIS1 gene (PAFAH1B1). | Profiles RNSClinical and molecular basis of classical lissencephaly: Mutations in the LIS1 gene (PAFAH1B1). | Profiles RNS
Cardoso C, Leventer RJ, Dowling JJ, Ward HL, Chung J, Petras KS, Roseberry JA, Weiss AM, Das S, Martin CL, Pilz DT, Dobyns WB, Ledbetter DH. Clinical and molecular basis of classical lissencephaly: Mutations in the LIS1 gene (PAFAH1B1). Hum Mutat. 2002 Jan; 19(1):4-15 ...
https://profiles.uchicago.edu/profiles/display/219337
1-alkyl-2-acetylglycerophosphocholine esterase - Wikipedia1-alkyl-2-acetylglycerophosphocholine esterase - Wikipedia
256 (1): 175-8. PMID 7451433. PAF+acetylhydrolase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.1 ... The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction 1-alkyl-2-acetyl-sn-glycero-3- ... The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common ... Blank ML, Lee T, Fitzgerald V, Snyder F (1981). "A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a ...
https://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase
3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase - BRENDA Enzyme Database3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase - BRENDA Enzyme Database
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine. + H2O. = 1-alkyl-sn-glycero-3-phosphocholine. + acetate. ... 3.1.1.47: 1-alkyl-2-acetylglycerophosphocholine esterase. This is an abbreviated version!. For detailed information about 1- ... More, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase, alkylacetyl-GPC:acetylhydrolase, deacetylase, 1-alkyl-2- ... 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, type I platelet-activating factor acetylhydrolase, plasma PAF ...
https://brenda-enzymes.org/all_enzymes.php?ecno=3.1.1.47&table=Temperature_Stability
US8454994B2 - Stable pharmaceutical composition and methods of using same - Google Patents
125000006724 (C1-C5) alkyl ester group Chemical group 0.000 description 1 * ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-ethylpyrrolidin-2-one ... 229940068917 Polyethylene Glycols Drugs 0.000 description 2 * 206010045261 Type IIa hyperlipidaemia Diseases 0.000 description ... 206010030113 Oedema Diseases 0.000 description 2 * 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 description ... 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 2 * 229920003171 Poly (ethylene oxide) Polymers 0.000 ...
https://patents.google.com/patent/US8454994/en
SMART: Pfam domain PAF-AH p IISMART: Pfam domain PAF-AH p II
Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipase A2, and is involved in regulation of inflammation through the inactivation of platelet-activating factor and polar phospholipids [ (PUBMED:9645224) ]. ...
https://smart.embl.de/smart/do_annotation.pl?DOMAIN=Pfam:PAF-AH_p_II&START=47&END=122&E_VALUE=1e-27&TYPE=PFAM&BLAST=AAGSGHSKIPKGNGSYPVGCTDLMFGYGNESVFVRLYYPAQDQGRLDTVWIPNKEYFLGLSIFLGTPSIVGNILHL
Code System Concept
1-Alkyl-2-acetylglycerophosphocholine esterase Current Synonym true false 3040606019 Lipoprotein associated phospholipase A2 ... 1-alkyl-2-acetylglycerophosphocholine esterase (substance). Code System Preferred Concept Name. 1-alkyl-2- ... acetylglycerophosphocholine esterase (substance). Concept Status. Published. Concept Status Date. 09/01/2020. ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=112040006
Geisha
platelet-activating factor acetylhydrolase,1-alkyl-2-acetylglycerophosphocholine esterase,2-acetyl-1-alkylglycerophosphocholine ... esterase,LDL-PLA(2),LDL-associated phospholipase A2,PAF 2-acylhydrolase,PAF acetylhydrolase,phospholipase A2, group VII ( ...
http://geisha.arizona.edu/geisha/search.jsp?geisha_id=PLA2G7.UApcr
A pleiotropic QTL on 2p influences serum Lp-PLA<sub>2</sub> activity and LDL cholesterol concentration in a baboon model for...A pleiotropic QTL on 2p influences serum Lp-PLA<sub>2</sub> activity and LDL cholesterol concentration in a baboon model for...
Y1 - 2008/2. N2 - Lipoprotein-associated phospholipase A2 (Lp-PLA2), the major portion of which is bound to low-density ... 2, 02.2008, p. 667-673.. Research output: Contribution to journal › Article › peer-review ... The QTL-specific correlation between the traits (ρQ = 0.62) was significantly different from both zero and 1 (P[ρQ = 0] = 0.047 ... A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics ...
https://ohsu.pure.elsevier.com/en/publications/a-pleiotropic-qtl-on-2p-influences-serum-lp-plasub2sub-activity-a
Gene locus Report for: mizye-a0a210q4j1
2 UniProt : A0A210Q4J1, B1A9T4. 2 Interpro : A0A210Q4J1, B1A9T4. 2 Prodom : A0A210Q4J1, B1A9T4. 2 Pfam : A0A210Q4J1, B1A9T4. 2 ... Ref: Nat Ecol Evol, 1:120, 2017 : PubMed. Abstract. ESTHER: Wang_2017_Nat.Ecol.Evol_1_120. PubMedSearch: Wang 2017 Nat.Ecol. ... Evol 1 120. PubMedID: 28812685. Gene_locus related to this paper: mizye-a0a210qls6, mizye-a0a210qis3, mizye-a0a210qg00, mizye- ... ACHE : mizye-a0a210qls6Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis). Acetylcholinesterase PYE-5989.14.1 ...
https://bioweb.supagro.inrae.fr/ESTHER/gene_locus?name=mizye-a0a210q4j1&class=Gene_locus
Department of Medicine - Research output - Creighton University
Gupta, P., Giehler, K., Walters, R. W., Meyerink, K. & Modrykamien, A. M., Feb 1 2014, In: Respiratory Care. 59, 2, p. 170-177 ... Gallagher, J. C., Jindal, P. S. & Smith, L. M., Jan 1 2014, In: Journal of Bone and Mineral Research. 29, 1, p. 173-181 9 p.. ... Tarasova, V. D., Trepp-Carrasco, A. G., Thompson, R., Recker, R. R., Chong, W. H., Collins, M. T. & Armas, L. A. G., Nov 1 2013 ... Heaney, R. P., Jan 2014, In: Nutrition Reviews. 72, 1, p. 48-54 7 p.. Research output: Contribution to journal › Article › peer ...
https://creighton.pure.elsevier.com/en/organisations/department-of-medicine/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontoperiodical%2Farticle&ordering=publicationYearThenTitle&descending=false&page=28
Bond University Nutrition and Dietetics Research Group - Research Outputs - Bond University Research Portal
Law, L., Kelly, J. T., Savill, H., Wallen, M. P., Hickman, I. J., Erku, D. & Mayr, H., 2 Feb 2022, (E-pub ahead of print) In: ... English, C. J., Mayr, H. L., Lohning, A. E. & Reidlinger, D. P., 1 Jun 2022, In: Nutrition Reviews. 80, 6, p. 1371-1391 21 p., ... Bailey, N. W., Bridgman, T. K., Marx, W. & Fitzgerald, P. B., 1 Dec 2016, In: Mindfulness. 7, 6, p. 1249-1255 7 p.. Research ... Crichton, M., Davidson, A. R., Innerarity, C., Marx, W., Lohning, A., Isenring, E. & Marshall, S., 1 Jun 2022, In: American ...
https://research.bond.edu.au/en/organisations/bond-university-nutrition-and-dietetics-research-group/publications/?ordering=type&descending=false&page=7
Aileen P. McGinn - Publications - Albert Einstein College of MedicineAileen P. McGinn - Publications - Albert Einstein College of Medicine
Tanenbaum, E. J., Johnson, J. H., Jordan, E., Cottral, J., Tenore, C., Burton, W. B., McGinn, A. P. & Raff, A. C., Dec 1 2016, ... Hochfelder, C. G., McGinn, A. P., Mehta, V., Castellucci, E., Kabarriti, R. & Ow, T. J., Nov 1 2020, In: Laryngoscope. 130, 11 ... Hawks, R. M., McGinn, A. P., Bernstein, P. S. & Tobin, J. N., Aug 1 2018, In: Maternal and child health journal. 22, 8, p. 1103 ... Khan, U. I., McGinn, A. P., Isasi, C. R., Groisman-Perelstein, A., Diamantis, P. M., Ginsberg, M. & Wylie-Rosett, J., Jun 1 ...
https://einstein.pure.elsevier.com/en/persons/aileen-p-mcginn/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) as a Marker of Coronary Heart Disease - Fingerprint - Universitas...
Dive into the research topics of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) as a Marker of Coronary Heart Disease. Together they form a unique fingerprint. ...
https://scholar.ui.ac.id/en/publications/lipoprotein-associated-phospholipase-a2-lp-pla2-as-a-marker-of-co/fingerprints/
Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk fartors, angiographic coronary...
Y1 - 2005/1. N2 - Aims: We aimed to evaluate the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) with coronary ... 2, 01.2005, p. 137-144.. Research output: Contribution to journal › Article › peer-review ... European heart journal, 26(2), 137-144. https://doi.org/10.1093/eurheartj/ehi010 ...
https://utsouthwestern.pure.elsevier.com/en/publications/association-of-lipoprotein-associated-phospholipase-a2-levels-wit
Bond University Nutrition and Dietetics Research Group - Research Outputs - Bond University Research Portal
English, C. J., Mayr, H. L., Lohning, A. E. & Reidlinger, D. P., 1 Jun 2022, In: Nutrition Reviews. 80, 6, p. 1371-1391 21 p., ... Murray, E. M., Hickman, I. J., Isbel, N. M. & Campbell, K. L., Sep 2015, In: Nephrology. 20, S3, p. 58-58 1 p., 150.. Research ... Crichton, M., Marx, W., Lohning, A. E., Isenring, E. & Marshall, S., Aug 2020, In: Nutrition and Dietetics. 77, S1, p. 29-27 2 ... Desbrow, B., Irwin, C., Delang, N. & Cox, G. R., Jul 2020, In: Medicine and Science in Sports and Exercise. 52, 7S, p. 170 1 p. ...
https://research.bond.edu.au/en/organisations/bond-university-nutrition-and-dietetics-research-group/publications/?ordering=title&descending=false&page=6
Human PLA2G7/PAF-AH/Lp-PLA2 Antibody MAB51061-100: R&D SystemsHuman PLA2G7/PAF-AH/Lp-PLA2 Antibody MAB51061-100: R&D Systems
Secretory phopholipase A2 is an enzyme that hydrolyses the Sn-2 ester bond of phospholipids, generating free fatty acids and ... 1 month, 2 to 8 °C under sterile conditions after reconstitution.. *6 months, -20 to -70 °C under sterile conditions after ... Human PLA2G7/PAF‑AH/Lp‑PLA2 ELISA Standard Curve. Recombinant Human PLA2G7/PAF-AH/Lp-PLA2 protein was serially diluted 2-fold ... In contrast to other classical sPLA2s, PLA2G‑VII has poor specificity toward Sn-2 long chain fatty acids, unless heavily ...
https://www.rndsystems.com/products/human-pla2g7-paf-ah-lp-pla2-antibody-973005_mab51061
Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32...
FINDINGS: Lp-PLA(2) activity and mass were associated with each other (r=0.51, 95% CI 0.47-0.56) and proatherogenic lipids. We ... INTERPRETATION: Lp-PLA(2) activity and mass each show continuous associations with risk of coronary heart disease, similar in ... RRs, adjusted for conventional risk factors, were: 1.10 (95% CI 1.05-1.16) with Lp-PLA(2) activity and 1.11 (1.07-1.16) with Lp ... RRs with Lp-PLA(2) did not differ significantly in people with and without initial stable vascular disease, apart from for ...
https://www.cardioscience.ox.ac.uk/publications/92402?1d903500-77a7-11ed-a56f-061ab7f93640
ENZYME: 3.-.-.ENZYME: 3.-.-.
... apo-salmochelin esterase 3.1.1.108 iron(III) enterobactin esterase 3.1.1.109 iron(III) salmochelin esterase 3.1.1.110 xylono-1, ... acetylxylan esterase 3.1.1.73 feruloyl esterase 3.1.1.74 cutinase 3.1.1.75 poly(3-hydroxybutyrate) depolymerase 3.1.1.76 poly(3 ... methyl ester esterase 3.1.1.86 rhamnogalacturonan acetylesterase 3.1.1.87 fumonisin B1 esterase 3.1.1.88 pyrethroid hydrolase ... alpha-amino-acid esterase 3.1.1.44 4-methyloxaloacetate esterase 3.1.1.45 carboxymethylenebutenolidase 3.1.1.46 deoxylimonate A ...
https://enzyme.expasy.org/EC/3.-.-.-
LongText Report for: 5ye9-pdb
6 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE,2-ACETYL-1- COMPND 7 ALKYLGLYCEROPHOSPHOCHOLINE ESTERASE,GROUP-VIIA PHOSPHOLIPASE A2, ... 2 AA110 VAL A 65 PHE A 72 1 N VAL A 65 O ASN A 133 SHEET 3 AA110 THR A 79 PRO A 86 -1 O TYR A 85 N GLY A 66 SHEET 4 AA110 ILE A ... 2 AA410 VAL B 65 PHE B 72 1 N VAL B 65 O ASN B 133 SHEET 3 AA410 THR B 79 PRO B 86 -1 O TYR B 85 N GLY B 66 SHEET 4 AA410 ILE B ... 1 O ILE A 417 N THR A 345 SHEET 1 AA2 2 THR A 95 LEU A 96 0 SHEET 2 AA2 2 THR A 129 THR A 130 -1 O THR A 130 N THR A 95 SHEET 1 ...
https://bioweb.supagro.inrae.fr/ESTHER/tree?name=5YE9-pdb&class=LongText
A revision of the lissencephaly and Miller-Dieker syndrome critical regions in chromosome 17p13.3. | Profiles RNS
Chong SS, Pack SD, Roschke AV, Tanigami A, Carrozzo R, Smith AC, Dobyns WB, Ledbetter DH. A revision of the lissencephaly and Miller-Dieker syndrome critical regions in chromosome 17p13.3. Hum Mol Genet. 1997 Feb; 6(2):147-55 ...
https://profiles.uchicago.edu/profiles/display/4448321
MMTBMMTB
3.1.1.59 juvenile-hormone esterase 3.1.1.72 acetylxylan esterase 3.1.1.73 feruloyl esterase - - - - - ... phthalate esterase 3.1.1.72 acetylxylan esterase 3.1.1.73 feruloyl esterase 3.1.1.74 cutinase 3.1.1.75 poly(3-hydroxybutyrate) ... 3.1.1.108 iron(III)-enterobactin esterase 3.1.1.13 sterol esterase 3.1.1.2 arylesterase 3.1.1.23 acylglycerol lipase 3.1.1.3 ... 2 1-octyne + 2 NADH + 2 H+ + 2 O2 <=> Octanoate + 7-octynoic_acid + 2 NAD+ + 2 H2O 1.14.15.3 alkane 1-monooxygenase - ...
https://metano.tu-bs.de/search/Octanoate%20=
i5k - EOG8ZSCHK
Site designed and maintained by Gregg Thomas, 2017 , Some of the CSS used to design this site is from the Pure CSS project. , Banner image ...
https://i5k.gitlab.io/ArthroFam-fams/EOG8ZSCHK.html
White Blood Cell Count Predicts All-Cause Mortality in Patients with Suspected Peripheral Arterial Disease<...
TY - JOUR. T1 - White Blood Cell Count Predicts All-Cause Mortality in Patients with Suspected Peripheral Arterial Disease. AU - Arain, Faisal A.. AU - Khaleghi, Mahyar. AU - Bailey, Kent R.. AU - Lahr, Brian D.. AU - Rooke, Thom W.. AU - Kullo, Iftikhar J.. N1 - Funding Information: Funding: Supported by National Institutes of Health grants HL75794 and HL81331. Dr Arain is supported by the National Institutes of Health Vascular Medicine Training Program K12 grant (HL 083797). PY - 2009/9. Y1 - 2009/9. N2 - Objective: We investigated whether markers of inflammation-white blood cell (WBC) count, C-reactive protein (CRP), and lipoprotein-associated phospholipase A2-are associated with mortality in patients referred for noninvasive lower-extremity arterial evaluation. Methods: Participants (n = 242, mean age 68 years, 54% men) were followed for a median of 71 months. Ankle-brachial index (ABI), WBC count, plasma CRP, and lipoprotein-associated phospholipase A2 were measured at the start of the ...
https://mayoclinic.pure.elsevier.com/en/publications/white-blood-cell-count-predicts-all-cause-mortality-in-patients-w
Novel enzymatic method for assaying Lp-PLA|sub|2|/sub| in serum - Fingerprint - Kyushu University
Novel enzymatic method for assaying Lp-PLA2 in serum. Saki Yamaura, Shin ichi Sakasegawa, Emisa Koguma, Shigeru Ueda, Yuzo ... Dive into the research topics of Novel enzymatic method for assaying Lp-PLA2 in serum. Together they form a unique ...
https://kyushu-u.pure.elsevier.com/en/publications/novel-enzymatic-method-for-assaying-lp-plasub2sub-in-serum/fingerprints/
Institute for Translational Research - Publications - HSC
Johnson, L. A., Mauer, C., Jahn, D., Song, M., Wyshywaniuk, L., Hall, J. R., Balldin, V. H. & OBryant, S. E., 1 Apr 2013, In: ... Chaudhari, K., Sumien, N., Johnson, L., DAgostino, D., Edwards, M., Paxton, R. J., Hall, J. R. & OBryant, S. E., 1 Oct 2016, ... Johnson, L. A., Sohrabi, H. R., Hall, J. R., Kevin, T., Edwards, M., OBryant, S. E. & Martins, R. N., 1 Aug 2015, In: ... Edwards, M., Hall, J., Williams, B., Johnson, L. & OBryant, S., 2015, In: Journal of Alzheimers Disease. 49, 1, p. 221-228 8 ...
https://experts.unthsc.edu/en/organisations/institute-for-translational-research/publications/?page=2
Effect of darapladib on major coronary events after an acute coronary syndrome: The SOLID-TIMI 52 randomized clinical trial -...
Dive into the research topics of Effect of darapladib on major coronary events after an acute coronary syndrome: The SOLID-TIMI 52 randomized clinical trial. Together they form a unique fingerprint. ...
https://utsouthwestern.pure.elsevier.com/en/publications/effect-of-darapladib-on-major-coronary-events-after-an-acute-coro/fingerprints/
Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells<...
TY - JOUR. T1 - Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. AU - Biancone, Luigi. AU - Cantaluppi, Vincenzo. AU - Segoloni, Giuseppe. AU - Boccellino, Mariarosaria. AU - Del Sorbo, Lorenzo. AU - Conaldi, Pier Giulio. AU - Tjoelker, Larry W.. AU - Maruyama, Shoici. AU - Cantu, Edward. AU - Stern, David. AU - Andres, Giuseppe. AU - Camussi, Giovanni. PY - 2000/10/27. Y1 - 2000/10/27. N2 - Background. Platelet-activating factor (PAF) is a phospholipid mediator of inflammation which has been implicated in rejection. The interaction of anti-α-galactosyl natural antibodies (anti-α gal Abs) with endothelial cells is the initial step for the development of xenograft rejection. In our study, we stimulated porcine aorthic endothelial cells (PAEC) with anti-α gal IgG to investigate the synthesis of PAF from PAEC and its biological consequences. Methods and Results. PAF was extracted and chromatografically purified from ...
https://moh-it.pure.elsevier.com/en/publications/role-of-platelet-activating-factor-in-functional-alterations-indu
ENZYME: 3.1.1.ENZYME: 3.1.1.
... apo-salmochelin esterase 3.1.1.108 iron(III) enterobactin esterase 3.1.1.109 iron(III) salmochelin esterase 3.1.1.110 xylono-1, ... acetylxylan esterase 3.1.1.73 feruloyl esterase 3.1.1.74 cutinase 3.1.1.75 poly(3-hydroxybutyrate) depolymerase 3.1.1.76 poly(3 ... methyl ester esterase 3.1.1.86 rhamnogalacturonan acetylesterase 3.1.1.87 fumonisin B1 esterase 3.1.1.88 pyrethroid hydrolase ... alpha-amino-acid esterase 3.1.1.44 4-methyloxaloacetate esterase 3.1.1.45 carboxymethylenebutenolidase 3.1.1.46 deoxylimonate A ...
https://enzyme.expasy.org/EC/3.1.1.-
LongText Report for: 5jan-pdb
5 ESTERASE,2-ACETYL-1-ALKYLGLYCEROPHOSPHOCHOLINE ESTERASE,GROUP-VIIA COMPND 6 PHOSPHOLIPASE A2,GVIIA-PLA2,LDL-ASSOCIATED ... 1 O THR A 130 N THR A 95 SHEET 3 AA111 SER A 64 PHE A 72 1 N VAL A 65 O ASN A 133 SHEET 4 AA111 THR A 79 SER A 87 -1 O LEU A 83 ... 1 AC2 4 ARG A 92 LEU A 93 PRO A 325 ALA A 326 SITE 1 AC3 3 GLU A 285 HOH A 678 HOH A 719 SITE 1 AC4 7 ASP A 89 LEU A 153 GLU A ... 1 O ILE A 417 N THR A 345 SHEET 1 AA2 2 ALA A 186 TYR A 189 0 SHEET 2 AA2 2 SER A 202 TYR A 205 -1 O LEU A 204 N THR A 187 LINK ...
https://bioweb.supagro.inrae.fr/ESTHER/tree?name=5JAN-pdb&class=LongText
PINX1 and PAFAH1B2 - Wiki-MPMPINX1 and PAFAH1B2 - Wiki-MPM
PIN2 (TERF1) interacting telomerase inhibitor 1. platelet activating factor acetylhydrolase 1b catalytic subunit 2. ...
https://hagrid.dbmi.pitt.edu/wiki-MPM/index.php/pair/view/54984/5049
MeSH BrowserMeSH Browser
Esterases [D08.811.277.352] * Carboxylic Ester Hydrolases [D08.811.277.352.100] * Phospholipases [D08.811.277.352.100.680] * ... sPLA(2) Term UI T316230. LexicalTag ABB. ThesaurusID NLM (2008). SPLA2 Phospholipases Term UI T689426. Date01/17/2007. ... sPLA(2) sPLA2 sPLA2s Registry Number. EC 3.1.1.4. Previous Indexing. Phospholipases A (1980-2007). Public MeSH Note. 2008; ... 1-Alkyl-2-acetylglycerophosphocholine Esterase [D08.811.277.352.100.680.750.937.249] * Phospholipases A2, Calcium-Independent [ ...
https://meshb-prev.nlm.nih.gov/record/ui?ui=D054497
1.47Coronary DiseaseAcetylhydrolasePhospholipaseActivityCytoplasmicEnzymeGenesProteinSignificantlyJournalMonthPhaseLIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2Platelet-activaAtherosclerosisStrokeCoronaryPhospholipidVascularBiologicalHumanIndividualsRiskPopulation
1.471
  • The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O ⇌ {\displaystyle \rightleftharpoons } 1-alkyl-sn-glycero-3-phosphocholine + acetate The former is also known as platelet-activating factor. (wikipedia.org)
Coronary Disease1
  • Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. (ox.ac.uk)
Acetylhydrolase2
  • There are multiple enzymes with this function: Lipoprotein-associated phospholipase A2 Platelet-activating factor acetylhydrolase 2, cytoplasmic Platelet-activating factor acetylhydrolase 1b: regulatory subunit 1, catalytic subunit 2, catalytic subunit 3 This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. (wikipedia.org)
  • Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. (wikipedia.org)
Phospholipase2
  • Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ), the major portion of which is bound to low-density lipoprotein, is an independent biomarker of cardiovascular disease risk. (elsevier.com)
  • BACKGROUND: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an inflammatory enzyme expressed in atherosclerotic plaques, is a therapeutic target being assessed in trials of vascular disease prevention. (ox.ac.uk)
Activity9
  • To search for common genetic determinants of variation in both Lp-PLA 2 activity and LDL cholesterol (LDL-C) concentration, we assayed these substances in serum from 679 pedigreed baboons. (elsevier.com)
  • Using a maximum likelihood-based variance components approach, we detected significant evidence for a QTL affecting Lp-PLA 2 activity (LOD = 2.79, genome-wide P = 0.039) and suggestive evidence for a QTL affecting LDL-C levels (LOD = 2.16) at the same location on the baboon ortholog of human chromosome 2p. (elsevier.com)
  • 0.00001), we conducted bivariate linkage analyses of Lp-PLA 2 activity and LDL-C concentration. (elsevier.com)
  • We conclude that polymorphisms at the QTL described in this study exert some genetic effects that are shared between Lp-PLA 2 activity and LDL-C concentration. (elsevier.com)
  • We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances. (ox.ac.uk)
  • FINDINGS: Lp-PLA(2) activity and mass were associated with each other (r=0.51, 95% CI 0.47-0.56) and proatherogenic lipids. (ox.ac.uk)
  • We noted roughly log-linear associations of Lp-PLA(2) activity and mass with risk of coronary heart disease and vascular death. (ox.ac.uk)
  • INTERPRETATION: Lp-PLA(2) activity and mass each show continuous associations with risk of coronary heart disease, similar in magnitude to that with non-HDL cholesterol or systolic blood pressure in this population. (ox.ac.uk)
  • Associations of Lp-PLA(2) mass and activity are not exclusive to vascular outcomes, and the vascular associations depend at least partly on lipids. (ox.ac.uk)
Cytoplasmic1
  • Most secretory PLA 2 s are stored in cytoplasmic granules and are released in the extracellular environment on appropriate cell activation. (rndsystems.com)
Enzyme2
  • The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. (wikipedia.org)
  • Secretory phopholipase A 2 is an enzyme that hydrolyses the Sn -2 ester bond of phospholipids, generating free fatty acids and lysophospholipids (1‑3). (rndsystems.com)
Genes2
  • Carboxylesterase 1C(1) two genes concatened , mizye-a0a210ptc4.2 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis). (inrae.fr)
  • Carboxylesterase 1C(1) two genes concatened , mizye-a0a210ptv1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis). (inrae.fr)
Protein1
  • Recombinant Human PLA2G7/PAF-AH/Lp-PLA2 protein was serially diluted 2-fold and captured by Mouse Anti-Human PLA2G7/PAF-AH/Lp-PLA2 Monoclonal Antibody (Catalog # MAB51061) coated on a Clear Polystyrene Microplate (Catalog # DY990 ). (rndsystems.com)
Significantly1
  • RRs with Lp-PLA(2) did not differ significantly in people with and without initial stable vascular disease, apart from for vascular death with Lp-PLA(2) mass. (ox.ac.uk)
Journal1
Month1
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution. (rndsystems.com)
Phase1
  • In contrast to other classical sPLA 2 s, PLA2G‑VII has poor specificity toward Sn -2 long chain fatty acids, unless heavily oxidized, and undergoes the catalysis of its substrates in the aqueous phase rather than at the interfacial surface of lipids. (rndsystems.com)
LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A22
  • A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. (nih.gov)
  • The early inflammatory biomarkers related to atherosclerosis, namely soluble vascular adhesion molecule-1 (sVCAM-1), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and lipoprotein-associated phospholipase A2 (Lp-PLA2), were compared with analyzed CFR, using TTE and adenosine or dipyridamole, measured within 2 weeks after coronary angiography. (springernature.com)
Platelet-activa1
  • This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). (nih.gov)
Atherosclerosis1
  • Methods-In a prospective case-cohort (n = 949) study in 12 762 apparently healthy, middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study, we first examined whether Lp-PLA 2 and hs-CRP levels improved the area under the receiver operator characteristic curve (AUC) for 5-year ischemic stroke risk. (elsevier.com)
Stroke3
  • Conclusion-Lp-PLA 2 and hs-CRP may be useful in individuals classified as intermediate risk for ischemic stroke by traditional risk factors. (elsevier.com)
  • Stroke , 40 (2), 376-381. (elsevier.com)
  • We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances. (nih.gov)
Coronary2
  • We noted roughly log-linear associations of Lp-PLA(2) activity and mass with risk of coronary heart disease and vascular death. (nih.gov)
  • INTERPRETATION: Lp-PLA(2) activity and mass each show continuous associations with risk of coronary heart disease, similar in magnitude to that with non-HDL cholesterol or systolic blood pressure in this population. (nih.gov)
Phospholipid1
  • It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. (nih.gov)
Vascular3
  • however, recent randomized trials of Lp-PLA 2 inhibition reported no beneficial effects on vascular diseases. (nih.gov)
  • RRs with Lp-PLA(2) did not differ significantly in people with and without initial stable vascular disease, apart from for vascular death with Lp-PLA(2) mass. (nih.gov)
  • Associations of Lp-PLA(2) mass and activity are not exclusive to vascular outcomes, and the vascular associations depend at least partly on lipids. (nih.gov)
Biological1
  • However, the biological variation of Lp-PLA 2 activity and corresponding reference change value (RCV) is unknown which limits interpretation of results. (umn.edu)
Human1
  • 1 Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States. (nih.gov)
Individuals2
  • In East Asians, a loss-of-function variant in the PLA2G7 gene can be used to assess the effects of genetically determined lower Lp-PLA 2 METHODS: PLA2G7 V279F (rs76863441) was genotyped in 91 428 individuals randomly selected from the China Kadoorie Biobank of 0.5 M participants recruited in 2004-08 from 10 regions of China, with 7 years' follow-up. (nih.gov)
  • We then examined how Lp-PLA 2 and hs-CRP levels altered classification of individuals into low-, intermediate-, or high-risk categories compared with traditional risk factors. (elsevier.com)
Risk1
  • METHODS: With use of individual records from 79 036 participants in 32 prospective studies (yielding 17 722 incident fatal or non-fatal outcomes during 474 976 person-years at risk), we did a meta-analysis of within-study regressions to calculate risk ratios (RRs) per 1 SD higher value of Lp-PLA(2) or other risk factor. (nih.gov)
Population1
  • 1 Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK. (nih.gov)