An enzyme localized predominantly within the plasma membrane of lymphocytes. It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. EC 2.3.1.23.
Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.
An enzyme that transfers acyl groups from acyl-CoA to glycerol-3-phosphate to form monoglyceride phosphates. It acts only with CoA derivatives of fatty acids of chain length above C-10. Also forms diglyceride phosphates. EC 2.3.1.15.
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.
An enzyme that catalyses the last step of the TRIACYLGLYCEROL synthesis reaction in which diacylglycerol is covalently joined to LONG-CHAIN ACYL COA to form triglyceride. It was formerly categorized as EC 2.3.1.124.
An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.
An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.

Synthesis of azidophospholipids and labeling of lysophosphatidylcholine acyltransferase from developing soybean cotyledons. (1/118)

A photoreactive substrate analog of lysophosphatidylcholine (LPC), 1-([(4-azidosalicyl)-12-amino)]dodecanoyl-sn-glycerol-3-phospho cholin e (azido-LPC) was synthesized. Fast atom bombardment mass spectrometry was employed to confirm the structures of azido-LPC and its intermediates. Azido-LPC was used to label putative acyl-CoA:LPC acyltransferase from microsomal membranes of developing soybean cotyledons. The synthesized substrate analog acts as a substrate for the target acyltransferases and phospholipases in the dark. When the microsomal membranes were incubated with the acyl acceptor analog and immediately photolyzed, LPC acyltransferase was irreversibly inhibited. Photoinactivation of the enzyme by the photoprobe decreased in the presence of LPC. Microsomal membranes were photolyzed with 125I-labeled azido-LPC and analyzed by SDS-PAGE followed by autoradiography. These revealed that the analog preferentially labeled 54- and 114-kDa polypeptides. Substrate protected the labeling of both the polypeptides. In our earlier report, the same polypeptides were also labeled with photoreactive acyl-CoA analogs, suggesting that these polypeptides could be putative LPC acyltransferase(s). These results demonstrated that the photoreactive phospholipid analog could be a powerful tool to label acyltransferases involved in lipid biosynthesis.  (+info)

Effects of inhibitors of arachidonic acid turnover on the production of prostaglandins by the guinea-pig uterus. (2/118)

The supply of free arachidonic acid from phospholipids is generally regarded as the rate-limiting step for prostaglandin (PG) synthesis by tissues. Two enzymes involved in arachidonic acid uptake into, and release from, phospholipids are acyl-CoA:lysophospholipid acyltransferase (ACLAT) and phospholipase A2 (PLA2), respectively. PGF2 alpha produced by the endometrium induces luteolysis in several species including guinea-pigs. Thimerosal, an inhibitor of ACLAT, and aristolochic acid, an inhibitor of PLA2, both reduced, in a concentration-dependent manner, the output of PGF2 alpha from guinea-pig endometrium cultured for 24 h on days 7 and 15 of the oestrous cycle. This study showed that the continual production of PGF 2 alpha by guinea-pig endometrium is not only dependent upon the activity of PLA2 for releasing free arachidonic acid for PGF2 alpha synthesis, but also on the incorporation of arachidonic acid into the phospholipid pool by the activity of ACLAT. The inhibitory effects of thimerosal and aristolochic acid on the outputs of PGE2 and 6-keto-PGF1 alpha were less marked, particularly on day 7 when the low output of PGE2 was unaffected and the output of 6-keto-PGF1 alpha was increased at the lower concentrations of thimerosal. This finding indicates that there are different pools of arachidonic acid bound as phospholipid for the syntheses of PGF2 alpha and 6-keto-PGF1 alpha by guinea-pig endometrium.  (+info)

Inhibition of the plastidial phosphatidylcholine synthesis by silver, copper, lead and mercury induced by formation of mercaptides with the lyso-PC acyltransferase. (3/118)

Plastids greatly rely on the import of extraplastidial precursors for the synthesis of their own lipids, and several studies have shown that a lyso-PC acyltransferase located in the envelope may be involved in the import process. Because the presence of heavy metals in soil or in nutrient solutions induces changes in the lipid composition of plastid membranes (and therefore greatly reduces the photosynthetic capability of plants), we analysed the effect of several metal salts on plastidial lyso-PC acyltransferase activity. Among the 12 heavy metals studied, silver, copper, mercury and lead inhibited this activity. Metal bound to the enzyme was not - or only very slightly - released from the protein except when thiol-reducing agents (and not imidazole) were added. The results strongly suggest that the inhibitory effect is due to a formation of mercaptide between metal and cysteine(s). The relationship between the inhibition of the plastidial lyso-PC acyltransferase activity and the in vivo effects of metal salts on the plastid membranes is discussed.  (+info)

Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide. (4/118)

Mononuclear phagocytes play a pivotal role in the progression of septic shock by producing tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators in response to lipopolysaccharide (LPS) from Gram-negative bacteria. Our previous studies have shown monocyte and macrophage activation correlate with changes in membrane phospholipid composition, mediated by acyltransferases. Interferon-gamma (IFN-gamma), which activates and primes these cells for enhanced inflammatory responses to LPS, was found to selectively activate lysophosphatidylcholine acyltransferase (LPCAT) (P < 0.05) but not lysophosphatidic acid acyltransferase (LPAAT) activity. When used to prime the human monocytic cell line MonoMac 6, the production of TNF-alpha and interleukin-6 (IL-6) was approximately five times greater in cells primed with IFN-gamma than unprimed cells. Two LPCAT inhibitors SK&F 98625 (diethyl 7-(3,4,5-triphenyl-2-oxo2,3-dihydro-imidazole-1-yl)heptane phosphonate) and YM 50201 (3-hydroxyethyl 5,3'-thiophenyl pyridine) strongly inhibited (up to 90%) TNF-alpha and IL-6 production in response to LPS in both unprimed MonoMac-6 cells and in cells primed with IFN-gamma. In similar experiments, these inhibitors also substantially decreased the response of both primed and unprimed peripheral blood mononuclear cells to LPS. Sequence-based amplification methods showed that SK&F 98625 inhibited TNF-alpha production by decreasing TNF-alpha mRNA levels in MonoMac-6 cells. Taken together, the data from these studies suggest that LPCAT is a key enzyme in both the pathways of activation (priming) and the inflammatory response to LPS in monocytes.  (+info)

Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. (5/118)

Recent studies have suggested that formation of Golgi membrane tubules involves the generation of membrane-associated lysophospholipids by a cytoplasmic Ca2+-independent phospholipase A2 (PLA2). Herein, we provide additional support for this idea by showing that inhibition of lysophospholipid reacylation by a novel Golgi-associated lysophosphatidylcholine acyltransferase (LPAT) induces the rapid tubulation of Golgi membranes, leading in their retrograde movement to the endoplasmic reticulum. Inhibition of the Golgi LPAT was achieved by 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976), a previously characterized antagonist of acyl-CoA cholesterol acyltransferase. The effect of CI-976 was similar to that of brefeldin A, except that the coatomer subunit beta-COP remained on Golgi-derived membrane tubules. CI-976 also enhanced the cytosol-dependent formation of tubules from Golgi complexes in vitro and increased the levels of lysophosphatidylcholine in Golgi membranes. Moreover, preincubation of cells with PLA2 antagonists inhibited the ability of CI-976 to induce tubules. These results suggest that Golgi membrane tubule formation can result from increasing the content of lysophospholipids in membranes, either by stimulation of a PLA2 or by inhibition of an LPAT. These two opposing enzyme activities may help to coordinately regulate Golgi membrane shape and tubule formation.  (+info)

The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase(s) in human platelets. (6/118)

The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferases (EC 2.3.1.23) have been studied in human platelet lysates by using endogenously formed [14C]acyl-CoA from [14C]fatty acid, ATP and CoA in the presence of 1-acyl-lysophosphatidyl-choline (lysoPC), -ethanolamine (lysoPE), -serine (lysoPS) or -inositol (lysoPI). Linoleic acid as fatty acid substrate had the highest affinity to acyl-CoA:1-acyl-lysophospholipid acyltransferase with lysoPC as variable substrate, followed by eicosapentaenoic acid (EPA) and arachidonic acid (AA). The activity at optimal conditions was 7.4, 7.3 and 7.2 nmol/min per 10(9) platelets with lysoPC as substrate, with linoleic acid, AA and EPA respectively. EPA and AA were incorporated into all lyso-forms. Linoleic acid was also incorporated into lysoPE at a high rate, but less into lysoPS and lysoPI. DHA was incorporated into lysoPC and lysoPE, but only slightly into lysoPI and lysoPS. Whereas incorporation of all fatty acids tested was maximal for lysoPC and lysoPI at 200 and 80 microM respectively, maximal incorporation needed over 500 microM for lysoPE and lysoPS. The optimal concentration for [14C]fatty acid substrates was in the range 15-150 microM for all lysophospholipids. Competition experiments with equimolar concentrations of either lysoPC and lysoPI or lysoPE resulted in formation of [14C]PC almost as if lysoPI or lysoPE were not added to the assay medium.  (+info)

Effect of apoprotein B conformation on the activation of lysolecithin acyltransferase and lecithin: cholesterol acyltransferase. Studies with subfractions of low density lipoproteins. (7/118)

In order to determine the role of apoprotein (apo) B conformation in the activation of the lysolecithin acyl-transferase reaction, we studied the activation of purified enzyme by various subfractions of low density lipoprotein (LDL), isolated by density gradient centrifugation. The activation of LAT correlated positively with the density of LDL and negatively with cholesterol/protein and triglyceride (TG)/protein ratios. The enzyme activation was also positively correlated with the number of trinitrobenzenesulfonic acid-reactive lysine amino groups, which increased with increasing density of LDL. The immunoaffinity of the LDL subfractions for B1B6, a monoclonal antibody directed to the receptor-binding region of apoB, increased with increasing density, while the affinity toward C1.4, a monoclonal antibody directed to the amino-terminal region of apoB, was not altered. Enrichment of normal whole LDL with TG resulted in a 45% reduction in enzyme activation, a 27% decrease in the number of trinitrobenzenesulfonic acid-reactive lysine groups, and a marked reduction in the immunoaffinity for B1B6. All these parameters reversed to normal when the TG-enriched LDL was treated with milk lipoprotein lipase, which specifically reduced the TG content of LDL. The LDL subfractions also supported cholesterol esterification by the purified enzyme, in parallel with lysolecithin esterification, indicating that apoB can also serve as an activator of the lecithin-cholesterol acyltransferase reaction. These results strongly suggest that the localized conformational change of apoB which occurs during the TG depletion of the precursor particle is critical for its activation of acyltransferase reactions, in a manner analogous to its interaction with the cellular receptors.  (+info)

Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis. (8/118)

When the yeast protein Ypr140w was expressed in Escherichia coli, a lyso-PC [lysophosphatidylcholine (1-acylglycerophosphorylcholine)] acyltransferase activity was found associated with the membranes of the bacteria. To our knowledge, this is the first identification of a protein capable of catalysing the acylation of lyso-PC molecules to form PC. Fluorescence microscopy analysis of living yeasts revealed that the fusion protein Ypr140w-green fluorescent protein is targeted to the mitochondria. Moreover, in contrast with wild-type cells, in the absence of acyl-CoA, the yeast mutant deleted for the YPR140w gene has no lyso-PC acyltransferase activity associated with the mitochondrial fraction. When yeast cells were grown in the presence of lactate, the mutant synthesized 2-fold more triacylglycerols when compared with the wild-type. Moreover, its mitochondrial membranes contained a lesser amount of PC and cardiolipin, and the fatty acid composition of these latter was greatly changed. These modifications were accompanied by a 2-fold increase in the respiration rates (states 3 and 4) of the mitochondria. The relationship between the deletion of the YPR140w gene and the lipid composition of the ypr140wDelta cells is discussed.  (+info)

1-Acylglycerophosphocholine O-Acyltransferase is an enzyme that belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. It is responsible for catalyzing the reaction that transfers an acyl group from an acyl-CoA to the sn-2 position of 1-acylglycerophosphocholine, resulting in the formation of phosphatidylcholine, which is a major component of biological membranes. This enzyme plays a crucial role in lipid metabolism and has been implicated in various diseases, including atherosclerosis, non-alcoholic fatty liver disease, and cancer.

Acyltransferases are a group of enzymes that catalyze the transfer of an acyl group (a functional group consisting of a carbon atom double-bonded to an oxygen atom and single-bonded to a hydrogen atom) from one molecule to another. This transfer involves the formation of an ester bond between the acyl group donor and the acyl group acceptor.

Acyltransferases play important roles in various biological processes, including the biosynthesis of lipids, fatty acids, and other metabolites. They are also involved in the detoxification of xenobiotics (foreign substances) by catalyzing the addition of an acyl group to these compounds, making them more water-soluble and easier to excrete from the body.

Examples of acyltransferases include serine palmitoyltransferase, which is involved in the biosynthesis of sphingolipids, and cholesteryl ester transfer protein (CETP), which facilitates the transfer of cholesteryl esters between lipoproteins.

Acyltransferases are classified based on the type of acyl group they transfer and the nature of the acyl group donor and acceptor molecules. They can be further categorized into subclasses based on their sequence similarities, three-dimensional structures, and evolutionary relationships.

Glycerol-3-Phosphate O-Acyltransferase (GPAT) is an enzyme that plays a crucial role in the biosynthesis of triacylglycerols and phospholipids, which are major components of cellular membranes and energy storage molecules. The GPAT enzyme catalyzes the initial and rate-limiting step in the glycerolipid synthesis pathway, specifically the transfer of an acyl group from an acyl-CoA donor to the sn-1 position of glycerol-3-phosphate, forming lysophosphatidic acid (LPA). This reaction is essential for the production of various glycerolipids, including phosphatidic acid, diacylglycerol, and triacylglycerol. There are four isoforms of GPAT (GPAT1-4) in humans, each with distinct subcellular localizations and functions. Dysregulation of GPAT activity has been implicated in several pathological conditions, such as metabolic disorders, cardiovascular diseases, and cancers.

Phosphatidylcholine-Sterol O-Acyltransferase (PCOAT, also known as Sterol O-Acyltransferase 1 or SOAT1) is an enzyme that plays a crucial role in the regulation of cholesterol metabolism. It is located in the endoplasmic reticulum and is responsible for the transfer of acyl groups from phosphatidylcholine to cholesterol, forming cholesteryl esters. This enzymatic reaction results in the storage of excess cholesterol in lipid droplets, preventing its accumulation in the cell membrane and potentially contributing to the development of atherosclerosis if not properly regulated.

Defects or mutations in PCOAT can lead to disruptions in cholesterol homeostasis, which may contribute to various diseases such as cardiovascular disorders, metabolic syndrome, and neurodegenerative conditions. Therefore, understanding the function and regulation of this enzyme is essential for developing therapeutic strategies aimed at managing cholesterol-related disorders.

Diacylglycerol O-Acyltransferase (DGAT) is an enzyme that catalyzes the final step in triacylglycerol synthesis, which is the formation of diacylglycerol and fatty acyl-CoA into triacylglycerol. This enzyme plays a crucial role in lipid metabolism and energy storage in cells. There are two main types of DGAT enzymes, DGAT1 and DGAT2, which share limited sequence similarity but have similar functions. Inhibition of DGAT has been explored as a potential therapeutic strategy for the treatment of obesity and related metabolic disorders.

Sterol O-Acyltransferase (SOAT, also known as ACAT for Acyl-CoA:cholesterol acyltransferase) is an enzyme that plays a crucial role in cholesterol homeostasis within cells. Specifically, it catalyzes the reaction of esterifying free cholesterol with fatty acyl-coenzyme A (fatty acyl-CoA) to form cholesteryl esters. This enzymatic activity allows for the intracellular storage of excess cholesterol in lipid droplets, reducing the levels of free cholesterol in the cell and thus preventing its potential toxic effects on membranes and proteins. There are two isoforms of SOAT, SOAT1 and SOAT2, which exhibit distinct subcellular localization and functions. Dysregulation of SOAT activity has been implicated in various pathological conditions, including atherosclerosis and neurodegenerative disorders.

Lecithin:cholesterol acyltransferase (LCAT) deficiency is a genetic disorder that affects the metabolism of cholesterol in the body. LCAT is an enzyme that helps to convert cholesterol into a form that can be easily transported in the bloodstream.

In LCAT deficiency, the activity of this enzyme is reduced or absent, leading to an accumulation of cholesterol in various tissues and organs of the body. This can result in a range of symptoms, including corneal opacities (clouding of the clear outer layer of the eye), hemolytic anemia (destruction of red blood cells), proteinuria (excess protein in the urine), and kidney failure.

There are two main types of LCAT deficiency: a complete form, known as fish-eye disease, which is characterized by corneal opacities but few other symptoms; and an incomplete form, known as LCAT deficiency with systemic involvement, which can affect multiple organs and systems of the body.

LCAT deficiency is caused by mutations in the LCAT gene, which provides instructions for making the LCAT enzyme. Inheritance is autosomal recessive, meaning that an individual must inherit two copies of the mutated gene (one from each parent) to develop the disorder.

... lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl ... In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction ...
In enzymology, a 2-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.62) is an enzyme that catalyzes the chemical reaction ... Other names in common use include 2-acylglycerol-3-phosphorylcholine acyltransferase, and 2-acylglycerophosphocholine ... The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase. ... Specificities of acyl coenzyme A:phospholipid acyltransferases". J. Biol. Chem. 240: 1905-1911. PMID 14299609. Van Den Bosch H ...
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... In enzymology, a 1-alkenylglycerophosphocholine O-acyltransferase (EC 2.3.1.104) is an enzyme that catalyzes the chemical ... Portal: Biology v t e (Articles with short description, Short description matches Wikidata, EC 2.3.1, Enzymes of unknown ... Arthur G, Choy PC (1986). "Acylation of 1-alkenyl-glycerophosphocholine and 1-acyl-glycerophosphocholine in guinea pig heart". ...
2-acylglycerophosphocholine O-acyltransferase, an enzyme purified in liver microsomes, catalyzes specifically the acylation of ... In contrast to these finding from rat liver microsomes, mammalian acyl transferase from dog lungs was found to exhibit no ... M. F. Frosolono; Slivka, S; Charms, BL (1971-01-01). "Acyl transferase activities in dog lung microsomes". Journal of Lipid ... Arthur, G. (Jul 1989). "Acylation of 2-acyl-glycerophosphocholine in guinea-pig heart microsomal fractions". Biochem J. 261 (2 ...
... may refer to: 1-acylglycerophosphocholine O-acyltransferase, an enzyme Phosphatidylcholine-sterol ... O-acyltransferase, an enzyme This set index page lists enzyme articles associated with the same name. If an internal link led ...
... lecithin-cholesterol acyltransferase), lecithin:cholesterol acyltransferase, and lysolecithin acyltransferase. This enzyme ... Other names in common use include lecithin---cholesterol acyltransferase, phospholipid---cholesterol acyltransferase, LCAT ( ... In enzymology, a phosphatidylcholine---sterol O-acyltransferase (EC 2.3.1.43) is an enzyme that catalyzes the chemical reaction ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ...
2-acylglycerophosphocholine O-acyltransferase EC 2.3.1.63: 1-alkylglycerophosphocholine O-acyltransferase EC 2.3.1.64: agmatine ... sphingosine N-acyltransferase EC 2.3.1.25: plasmalogen synthase EC 2.3.1.26: sterol O-acyltransferase EC 2.3.1.27: cortisol O- ... diacylglycerol-sterol O-acyltransferase EC 2.3.1.74: chalcone synthase EC 2.3.1.75: long-chain-alcohol O-fatty-acyltransferase ... tropine acyltransferase EC 2.3.1.186: pseudotropine acyltransferase EC 2.3.1.187: acetyl-S-ACP:malonate ACP transferase EC 2.3. ...
... diacylglycerol o-acyltransferase MeSH D08.811.913.050.425 - glycerol-3-phosphate O-acyltransferase MeSH D08.811.913.050.600 - ... phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050.646 - retinol O-fatty-acyltransferase MeSH D08.811.913.050. ... acetyl-CoA C-acyltransferase MeSH D08.811.913.050.134 - acetyltransferases MeSH D08.811.913.050.134.029 - acyl-carrier protein ... sterol O-acyltransferase MeSH D08.811.913.200.324 - acetolactate synthase MeSH D08.811.913.200.650 - transaldolase MeSH D08.811 ...
2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] Thus, the two substrates of this enzyme are ... and O-acyltransferase. MacDonald PN, Ong DE (1988). "Evidence for a lecithin-retinol acyltransferase activity in the rat small ... O-acyltransferase. Other names in common use include lecithin---retinol acyltransferase, phosphatidylcholine:retinol-(cellular- ... In enzymology, a phosphatidylcholine---retinol O-acyltransferase (EC 2.3.1.135) is an enzyme that catalyzes the chemical ...
2-acylglycerophosphocholine + a carboxylate It is an enzyme that resides in a class of enzymes called phospholipase that ... "Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine ... 65 (1): 94-101. doi:10.1271/bbb.65.94. PMID 11272851. Imae R, Inoue T, Kimura M, Kanamori T, Tomioka NH, Kage-Nakadai E, Mitani ... 1582 (1-3): 26-32. doi:10.1016/s1388-1981(02)00134-8. PMID 12069807. Portal: Biology (Articles with short description, Short ...
... lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl ... In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction ...
Lysophosphatidylcholine Acyltransferase 1 Deficiency Promotes Pulmonary Emphysema via Apoptosis of Alveolar Epithelial Cells. ... Masaki, K., Asakura, T., Sakurai, K. & Ohkusu, K., 2019 4月 1, In: BMJ case reports. 12, 4, e228914.. 研究成果: Comment/debate › 査読 ... Masaki, K., Fukunaga, K., Kawakami, Y. & Haque, R., 2019 3月 1, In: BMJ case reports. 12, 3, e228854.. 研究成果: Article › 査読 ... Nishie, M., Masaki, K., Kayama, Y. & Yoshino, T., 2021 3月 1, In: BMJ case reports. 14, 3, e241510.. 研究成果: Article › 査読 ...
Human LPC acyltransferase 2 ELISA Kit;Human LPCAT-2 ELISA Kit;Human lysoPC acyltransferase 2 ELISA Kit;Human 1-acylglycerol-3- ... Human lysophosphatidylcholine acyltransferase 2 ELISA Kit;Human acyl-CoA:lysophosphatidylcholine acyltransferase 2 ELISA Kit; ... phosphate O-acyltransferase 11 ELISA Kit;Human 1-AGP acyltransferase 11 ELISA Kit;Human 1-AGPAT 11 ELISA Kit;Human 1- ... acylglycerophosphocholine O-acyltransferase ELISA Kit;Human 1-alkylglycerophosphocholine O-acetyltransferase ELISA Kit;Human ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase. 3-Ketosteroid Isomerases use Steroid Isomerases ... 1-Sar-8-Ile Angiotensin II use 1-Sarcosine-8-Isoleucine Angiotensin II ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase. 3-Ketosteroid Isomerases use Steroid Isomerases ... 1-Sar-8-Ile Angiotensin II use 1-Sarcosine-8-Isoleucine Angiotensin II ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase. 3-Ketosteroid Isomerases use Steroid Isomerases ... 1-Sar-8-Ile Angiotensin II use 1-Sarcosine-8-Isoleucine Angiotensin II ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase. 3-Ketosteroid Isomerases use Steroid Isomerases ... 1-Sar-8-Ile Angiotensin II use 1-Sarcosine-8-Isoleucine Angiotensin II ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase. 3-Ketosteroid Isomerases use Steroid Isomerases ... 1-Sar-8-Ile Angiotensin II use 1-Sarcosine-8-Isoleucine Angiotensin II ... 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester ... 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
JRC_LH279_Brain_2020__1; P{R41H09-GAL4.DBD} ∩ P{R70G05-p65.AD} expression pattern; neuronbridge; is part of; female organism; ... 1 }, description: [], comment: [] }, query: Get JSON for Individual:Anatomy, version: 44725ae, dataset_license ... JRC_LH279_Brain_2020__1 JRC_LH279_Brain_2020__1 [VFB_00102813]. [JRC_LH279_Brain_2020__1; P{R41H09-GAL4.DBD} ∩ P{R70G05-p65.AD ... 1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
O-acyltransferase activity. transferase activity, transferring acyl groups. No GO terms in record ... 1-acylglycerol-3-phosphate O-acyltransferase activity. 1-acylglycerophosphocholine O-acyltransferase activity. ...
1-myristoyl-2-oleoylphosphatidylcholine + H2O <=> 2-oleylglycerophosphocholine + myristic_acid 3.1.1.32 phospholipase A1 - ... oleoyl-CoA + 1-myristoyl-sn-glycero-3-phosphocholine <=> CoA + 1-myristoyl-2-oleoylphosphatidylcholine 2.3.1.23 1- ... acylglycerophosphocholine O-acyltransferase - BRENDA: BS377420 ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =, poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose ... 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol ... 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol ... 1-acyl LPE is acylated to PE by LPEAT * 1-acyl LPE is ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
3-Ketoacyl CoA Thiolase use Acetyl-CoA C-Acyltransferase 3-Ketosteroid Isomerases use Steroid Isomerases ... 1,2-Benzoquinones use Benzoquinones 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase use Glycerophosphoinositol ... 1-Acylglycerol-3-Phosphate O-Acyltransferase 1-Acylglycerophosphocholine Acyltransferase use 1-Acylglycerophosphocholine O- ... 3-Phosphoshikimate 1-Carboxyvinyltransferase 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl) ...
2.3.1.62 2-acylglycerophosphocholine O-acyltransferase - BRENDA: BS321136 oleoyl-CoA + 2-arachidonoyl-sn-glycero-3- ... stearoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine <=> CoA + 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine 2.3. ... linoleoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine <=> CoA + 1-linoleoyl-2-arachidonoyl-sn-glycero-3-phosphocholine 2.3 ... palmitoyl-CoA + 2-arachidonoyl-sn-glycero-3-phosphocholine <=> CoA + 1-palmitoyl-2-arachidonoylphosphatidylcholine ...
... seriously disrupted glycerophospholipid metabolism by upregulating the contents of lysophosphatidylglycerol acyltransferase 1 ... The observed levels would result in estimated daily intakes from 0.01 to 12 µg per day or 0.0002 to 0.2 µg kg-1 bw day-1 for a ... For TAs, the obtained limit of detection (LOD) is 0.1 µg·kg-1 and the limit of quantification (LOQ) is 0.4 µg·kg-1 , while for ... In animal studies, 1,2-unsaturated PAs have proven to be genotoxic carcinogens. According to the scientific opinion expressed ...
  • Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. (wikipedia.org)
  • In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine ⇌ {\displaystyle \rightleftharpoons } CoA + 1,2-diacyl-sn-glycero-3-phosphocholine Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine. (wikipedia.org)
  • Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. (wikipedia.org)
  • In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine ⇌ {\displaystyle \rightleftharpoons } CoA + 1,2-diacyl-sn-glycero-3-phosphocholine Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine. (wikipedia.org)
  • The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase. (wikipedia.org)
  • An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (uams.edu)
  • This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. (wikipedia.org)
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. (bvsalud.org)
  • Serum PFOA at 3.75 mg/kg/day was 7.4 × 10 4 ng/mL 1 day postexposure, or 150-fold greater than the levels reported in individuals living near a PFOA production site. (nih.gov)
  • 1. Some strings either represent general, nonmedical concepts or are unnecessarily ambiguous. (nih.gov)