Enzymes: Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Oxidoreductases Acting on Aldehyde or Oxo Group Donors: A broad category of oxidoreductases that either reduce double bonds or oxidize single bonds between OXYGEN and CARBON in organic compounds.Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.Rhodobacter: A genus of gram-negative bacteria widely distributed in fresh water as well as marine and hypersaline habitats.Acyl-Carrier Protein S-Acetyltransferase: A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to form COENZYME A and acetyl-acyl-carrier protein.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.1-Acylglycerophosphocholine O-Acyltransferase: An enzyme localized predominantly within the plasma membrane of lymphocytes. It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. EC 2.3.1.23.Acyltransferases: Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.Lysophospholipase: An enzyme that catalyzes the hydrolysis of a single fatty acid ester bond in lysoglycerophosphatidates with the formation of glyceryl phosphatidates and a fatty acid. EC 3.1.1.5.Lysophospholipids: Derivatives of PHOSPHATIDIC ACIDS that lack one of its fatty acyl chains due to its hydrolytic removal.Acyl Coenzyme A: S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.Phosphodiesterase I: A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.1-Acylglycerol-3-Phosphate O-Acyltransferase: An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. This enzyme has alpha, beta, gamma, delta and epsilon subunits.Lysophosphatidylcholines: Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes one of the fatty acid moieties.Receptors, Lysophospholipid: A family of G-protein-coupled receptors that bind to specific LYSOPHOSPHOLIPIDS such as lysophosphatidic acid and lysosphinglipids such as sphingosine-1-phosphate. They play an important role in the formation and function of the CARDIOVASCULAR SYSTEM.Glycerol-3-Phosphate O-Acyltransferase: An enzyme that transfers acyl groups from acyl-CoA to glycerol-3-phosphate to form monoglyceride phosphates. It acts only with CoA derivatives of fatty acids of chain length above C-10. Also forms diglyceride phosphates. EC 2.3.1.15.Nicotinamide N-Methyltransferase: An enzyme found primarily in the LIVER that catalyzes the N-methylation of NICOTINAMIDE and other structurally related compounds.Guanidinoacetate N-Methyltransferase: This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanidinoacetate to CREATINE.Histamine N-Methyltransferase: An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of histamine in man. EC 2.1.1.8.Glycine N-Methyltransferase: An enzyme that catalyzes the METHYLATION of GLYCINE using S-ADENOSYLMETHIONINE to form SARCOSINE with the concomitant production of S-ADENOSYLHOMOCYSTEINE.Phosphatidylethanolamine N-Methyltransferase: An enzyme that catalyses three sequential METHYLATION reactions for conversion of phosphatidylethanolamine to PHOSPHATIDYLCHOLINE.Betaine-Homocysteine S-Methyltransferase: A ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to produce dimethylglycine and METHIONINE, respectively. This enzyme is a member of a family of ZINC-dependent METHYLTRANSFERASES that use THIOLS or selenols as methyl acceptors.Methyltransferases: A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.Catechol O-Methyltransferase: Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.Acetylserotonin O-Methyltransferase: An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylserotonin to form N-acetyl-5-methoxytryptamine (MELATONIN).Phenylethanolamine N-Methyltransferase: A methyltransferase that catalyzes the reaction of S-adenosyl-L-methionine and phenylethanolamine to yield S-adenosyl-L-homocysteine and N-methylphenylethanolamine. It can act on various phenylethanolamines and converts norepinephrine into epinephrine. (From Enzyme Nomenclature, 1992) EC 2.1.1.28.Metabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Docosahexaenoic Acids: C22-unsaturated fatty acids found predominantly in FISH OILS.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Myristic Acid: A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. It is used to synthesize flavor and as an ingredient in soaps and cosmetics. (From Dorland, 28th ed)Myristic Acids: 14-carbon saturated monocarboxylic acids.Fatty Acids, Unsaturated: FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Fatty Acids, Omega-3: A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)Linoleic Acids: Eighteen-carbon essential fatty acids that contain two double bonds.PC12 Cells: A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.Glycerol: A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.Stearic Acids: A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Contact Lenses: Lenses designed to be worn on the front surface of the eyeball. (UMDNS, 1999)Dairy Products: Raw and processed or manufactured milk and milk-derived products. These are usually from cows (bovine) but are also from goats, sheep, reindeer, and water buffalo.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Consumer Product SafetyKinetics: The rate dynamics in chemical or physical systems.Receptors, Lysophosphatidic Acid: A subfamily of lysophospholipid receptors with specificity for LYSOPHOSPHATIDIC ACIDS.
(1/118) Synthesis of azidophospholipids and labeling of lysophosphatidylcholine acyltransferase from developing soybean cotyledons.

A photoreactive substrate analog of lysophosphatidylcholine (LPC), 1-([(4-azidosalicyl)-12-amino)]dodecanoyl-sn-glycerol-3-phospho cholin e (azido-LPC) was synthesized. Fast atom bombardment mass spectrometry was employed to confirm the structures of azido-LPC and its intermediates. Azido-LPC was used to label putative acyl-CoA:LPC acyltransferase from microsomal membranes of developing soybean cotyledons. The synthesized substrate analog acts as a substrate for the target acyltransferases and phospholipases in the dark. When the microsomal membranes were incubated with the acyl acceptor analog and immediately photolyzed, LPC acyltransferase was irreversibly inhibited. Photoinactivation of the enzyme by the photoprobe decreased in the presence of LPC. Microsomal membranes were photolyzed with 125I-labeled azido-LPC and analyzed by SDS-PAGE followed by autoradiography. These revealed that the analog preferentially labeled 54- and 114-kDa polypeptides. Substrate protected the labeling of both the polypeptides. In our earlier report, the same polypeptides were also labeled with photoreactive acyl-CoA analogs, suggesting that these polypeptides could be putative LPC acyltransferase(s). These results demonstrated that the photoreactive phospholipid analog could be a powerful tool to label acyltransferases involved in lipid biosynthesis.  (+info)

(2/118) Effects of inhibitors of arachidonic acid turnover on the production of prostaglandins by the guinea-pig uterus.

The supply of free arachidonic acid from phospholipids is generally regarded as the rate-limiting step for prostaglandin (PG) synthesis by tissues. Two enzymes involved in arachidonic acid uptake into, and release from, phospholipids are acyl-CoA:lysophospholipid acyltransferase (ACLAT) and phospholipase A2 (PLA2), respectively. PGF2 alpha produced by the endometrium induces luteolysis in several species including guinea-pigs. Thimerosal, an inhibitor of ACLAT, and aristolochic acid, an inhibitor of PLA2, both reduced, in a concentration-dependent manner, the output of PGF2 alpha from guinea-pig endometrium cultured for 24 h on days 7 and 15 of the oestrous cycle. This study showed that the continual production of PGF 2 alpha by guinea-pig endometrium is not only dependent upon the activity of PLA2 for releasing free arachidonic acid for PGF2 alpha synthesis, but also on the incorporation of arachidonic acid into the phospholipid pool by the activity of ACLAT. The inhibitory effects of thimerosal and aristolochic acid on the outputs of PGE2 and 6-keto-PGF1 alpha were less marked, particularly on day 7 when the low output of PGE2 was unaffected and the output of 6-keto-PGF1 alpha was increased at the lower concentrations of thimerosal. This finding indicates that there are different pools of arachidonic acid bound as phospholipid for the syntheses of PGF2 alpha and 6-keto-PGF1 alpha by guinea-pig endometrium.  (+info)

(3/118) Inhibition of the plastidial phosphatidylcholine synthesis by silver, copper, lead and mercury induced by formation of mercaptides with the lyso-PC acyltransferase.

Plastids greatly rely on the import of extraplastidial precursors for the synthesis of their own lipids, and several studies have shown that a lyso-PC acyltransferase located in the envelope may be involved in the import process. Because the presence of heavy metals in soil or in nutrient solutions induces changes in the lipid composition of plastid membranes (and therefore greatly reduces the photosynthetic capability of plants), we analysed the effect of several metal salts on plastidial lyso-PC acyltransferase activity. Among the 12 heavy metals studied, silver, copper, mercury and lead inhibited this activity. Metal bound to the enzyme was not - or only very slightly - released from the protein except when thiol-reducing agents (and not imidazole) were added. The results strongly suggest that the inhibitory effect is due to a formation of mercaptide between metal and cysteine(s). The relationship between the inhibition of the plastidial lyso-PC acyltransferase activity and the in vivo effects of metal salts on the plastid membranes is discussed.  (+info)

(4/118) Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide.

Mononuclear phagocytes play a pivotal role in the progression of septic shock by producing tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators in response to lipopolysaccharide (LPS) from Gram-negative bacteria. Our previous studies have shown monocyte and macrophage activation correlate with changes in membrane phospholipid composition, mediated by acyltransferases. Interferon-gamma (IFN-gamma), which activates and primes these cells for enhanced inflammatory responses to LPS, was found to selectively activate lysophosphatidylcholine acyltransferase (LPCAT) (P < 0.05) but not lysophosphatidic acid acyltransferase (LPAAT) activity. When used to prime the human monocytic cell line MonoMac 6, the production of TNF-alpha and interleukin-6 (IL-6) was approximately five times greater in cells primed with IFN-gamma than unprimed cells. Two LPCAT inhibitors SK&F 98625 (diethyl 7-(3,4,5-triphenyl-2-oxo2,3-dihydro-imidazole-1-yl)heptane phosphonate) and YM 50201 (3-hydroxyethyl 5,3'-thiophenyl pyridine) strongly inhibited (up to 90%) TNF-alpha and IL-6 production in response to LPS in both unprimed MonoMac-6 cells and in cells primed with IFN-gamma. In similar experiments, these inhibitors also substantially decreased the response of both primed and unprimed peripheral blood mononuclear cells to LPS. Sequence-based amplification methods showed that SK&F 98625 inhibited TNF-alpha production by decreasing TNF-alpha mRNA levels in MonoMac-6 cells. Taken together, the data from these studies suggest that LPCAT is a key enzyme in both the pathways of activation (priming) and the inflammatory response to LPS in monocytes.  (+info)

(5/118) Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking.

Recent studies have suggested that formation of Golgi membrane tubules involves the generation of membrane-associated lysophospholipids by a cytoplasmic Ca2+-independent phospholipase A2 (PLA2). Herein, we provide additional support for this idea by showing that inhibition of lysophospholipid reacylation by a novel Golgi-associated lysophosphatidylcholine acyltransferase (LPAT) induces the rapid tubulation of Golgi membranes, leading in their retrograde movement to the endoplasmic reticulum. Inhibition of the Golgi LPAT was achieved by 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976), a previously characterized antagonist of acyl-CoA cholesterol acyltransferase. The effect of CI-976 was similar to that of brefeldin A, except that the coatomer subunit beta-COP remained on Golgi-derived membrane tubules. CI-976 also enhanced the cytosol-dependent formation of tubules from Golgi complexes in vitro and increased the levels of lysophosphatidylcholine in Golgi membranes. Moreover, preincubation of cells with PLA2 antagonists inhibited the ability of CI-976 to induce tubules. These results suggest that Golgi membrane tubule formation can result from increasing the content of lysophospholipids in membranes, either by stimulation of a PLA2 or by inhibition of an LPAT. These two opposing enzyme activities may help to coordinately regulate Golgi membrane shape and tubule formation.  (+info)

(6/118) The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase(s) in human platelets.

The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferases (EC 2.3.1.23) have been studied in human platelet lysates by using endogenously formed [14C]acyl-CoA from [14C]fatty acid, ATP and CoA in the presence of 1-acyl-lysophosphatidyl-choline (lysoPC), -ethanolamine (lysoPE), -serine (lysoPS) or -inositol (lysoPI). Linoleic acid as fatty acid substrate had the highest affinity to acyl-CoA:1-acyl-lysophospholipid acyltransferase with lysoPC as variable substrate, followed by eicosapentaenoic acid (EPA) and arachidonic acid (AA). The activity at optimal conditions was 7.4, 7.3 and 7.2 nmol/min per 10(9) platelets with lysoPC as substrate, with linoleic acid, AA and EPA respectively. EPA and AA were incorporated into all lyso-forms. Linoleic acid was also incorporated into lysoPE at a high rate, but less into lysoPS and lysoPI. DHA was incorporated into lysoPC and lysoPE, but only slightly into lysoPI and lysoPS. Whereas incorporation of all fatty acids tested was maximal for lysoPC and lysoPI at 200 and 80 microM respectively, maximal incorporation needed over 500 microM for lysoPE and lysoPS. The optimal concentration for [14C]fatty acid substrates was in the range 15-150 microM for all lysophospholipids. Competition experiments with equimolar concentrations of either lysoPC and lysoPI or lysoPE resulted in formation of [14C]PC almost as if lysoPI or lysoPE were not added to the assay medium.  (+info)

(7/118) Effect of apoprotein B conformation on the activation of lysolecithin acyltransferase and lecithin: cholesterol acyltransferase. Studies with subfractions of low density lipoproteins.

In order to determine the role of apoprotein (apo) B conformation in the activation of the lysolecithin acyl-transferase reaction, we studied the activation of purified enzyme by various subfractions of low density lipoprotein (LDL), isolated by density gradient centrifugation. The activation of LAT correlated positively with the density of LDL and negatively with cholesterol/protein and triglyceride (TG)/protein ratios. The enzyme activation was also positively correlated with the number of trinitrobenzenesulfonic acid-reactive lysine amino groups, which increased with increasing density of LDL. The immunoaffinity of the LDL subfractions for B1B6, a monoclonal antibody directed to the receptor-binding region of apoB, increased with increasing density, while the affinity toward C1.4, a monoclonal antibody directed to the amino-terminal region of apoB, was not altered. Enrichment of normal whole LDL with TG resulted in a 45% reduction in enzyme activation, a 27% decrease in the number of trinitrobenzenesulfonic acid-reactive lysine groups, and a marked reduction in the immunoaffinity for B1B6. All these parameters reversed to normal when the TG-enriched LDL was treated with milk lipoprotein lipase, which specifically reduced the TG content of LDL. The LDL subfractions also supported cholesterol esterification by the purified enzyme, in parallel with lysolecithin esterification, indicating that apoB can also serve as an activator of the lecithin-cholesterol acyltransferase reaction. These results strongly suggest that the localized conformational change of apoB which occurs during the TG depletion of the precursor particle is critical for its activation of acyltransferase reactions, in a manner analogous to its interaction with the cellular receptors.  (+info)

(8/118) Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis.

When the yeast protein Ypr140w was expressed in Escherichia coli, a lyso-PC [lysophosphatidylcholine (1-acylglycerophosphorylcholine)] acyltransferase activity was found associated with the membranes of the bacteria. To our knowledge, this is the first identification of a protein capable of catalysing the acylation of lyso-PC molecules to form PC. Fluorescence microscopy analysis of living yeasts revealed that the fusion protein Ypr140w-green fluorescent protein is targeted to the mitochondria. Moreover, in contrast with wild-type cells, in the absence of acyl-CoA, the yeast mutant deleted for the YPR140w gene has no lyso-PC acyltransferase activity associated with the mitochondrial fraction. When yeast cells were grown in the presence of lactate, the mutant synthesized 2-fold more triacylglycerols when compared with the wild-type. Moreover, its mitochondrial membranes contained a lesser amount of PC and cardiolipin, and the fatty acid composition of these latter was greatly changed. These modifications were accompanied by a 2-fold increase in the respiration rates (states 3 and 4) of the mitochondria. The relationship between the deletion of the YPR140w gene and the lipid composition of the ypr140wDelta cells is discussed.  (+info)

*  Phosphatidylcholine-sterol O-acyltransferase
... lecithin-cholesterol acyltransferase), lecithin:cholesterol acyltransferase, and lysolecithin acyltransferase. This enzyme ... Other names in common use include lecithin---cholesterol acyltransferase, phospholipid---cholesterol acyltransferase, LCAT ( ... In enzymology, a phosphatidylcholine---sterol O-acyltransferase (EC 2.3.1.43) is an enzyme that catalyzes the chemical reaction ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ...
*  Lysolecithin acyltransferase
... may refer to: 1-acylglycerophosphocholine O-acyltransferase, an enzyme Phosphatidylcholine-sterol ...
*  List of MeSH codes (D08)
... phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050.646 --- retinol O-fatty-acyltransferase MeSH D08.811.913.050. ... diacylglycerol o-acyltransferase MeSH D08.811.913.050.425 --- glycerol-3-phosphate O-acyltransferase MeSH D08.811.913.050.600 ... acetyl-CoA C-acyltransferase MeSH D08.811.913.050.134 --- acetyltransferases MeSH D08.811.913.050.134.029 --- acyl-carrier ... sterol O-acyltransferase MeSH D08.811.913.200.324 --- acetolactate synthase MeSH D08.811.913.200.650 --- transaldolase MeSH ...
*  1-Lysophosphatidylcholine
2-acylglycerophosphocholine O-acyltransferase, an enzyme purified in liver microsomes, catalyzes specifically the acylation of ... In contrast to these finding from rat liver microsomes, mammalian acyl transferase from dog lungs was found to exhibit no ... M. F. Frosolono; Slivka, S; Charms, BL (1971-01-01). "Acyl transferase activities in dog lung microsomes". Journal of Lipid ... Arthur, G. (Jul 1989). "Acylation of 2-acyl-glycerophosphocholine in guinea-pig heart microsomal fractions". Biochem J. 261 (2 ...
*  1-alkenylglycerophosphocholine O-acyltransferase
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... In enzymology, a 1-alkenylglycerophosphocholine O-acyltransferase (EC 2.3.1.104) is an enzyme that catalyzes the chemical ... Arthur G, Choy PC (1986). "Acylation of 1-alkenyl-glycerophosphocholine and 1-acyl-glycerophosphocholine in guinea pig heart". ... The systematic name of this enzyme class is acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase. This enzyme participates ...
*  List of EC numbers (EC 2)
2-acylglycerophosphocholine O-acyltransferase EC 2.3.1.63: 1-alkylglycerophosphocholine O-acyltransferase EC 2.3.1.64: agmatine ... sphingosine N-acyltransferase EC 2.3.1.25: plasmalogen synthase EC 2.3.1.26: sterol O-acyltransferase EC 2.3.1.27: cortisol O- ... retinol O-fatty-acyltransferase EC 2.3.1.77: triacylglycerol-sterol O-acyltransferase EC 2.3.1.78: heparan-a-glucosaminide N- ... tropine acyltransferase EC 2.3.1.186: pseudotropine acyltransferase EC 2.3.1.187: acetyl-S-ACP:malonate ACP transferase EC 2.3. ...
Lpcat4 - Lysophospholipid acyltransferase LPCAT4 - Mus musculus (Mouse) - Lpcat4 gene & protein  Lpcat4 - Lysophospholipid acyltransferase LPCAT4 - Mus musculus (Mouse) - Lpcat4 gene & protein
In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase ... Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; ... converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl- ... Lysophospholipid acyltransferase LPCAT4Add BLAST. 524. Amino acid modifications. Feature key. Position(s). DescriptionActions. ...
more infohttp://www.uniprot.org/uniprot/Q6NVG1
ENZYME: 2.-.-.  ENZYME: 2.-.-.
2-acylglycerophosphocholine O-acyltransferase 2.3.1.63 1-alkylglycerophosphocholine O-acyltransferase 2.3.1.64 Agmatine N(4)- ... sterol O-acyltransferase 2.3.1.74 Naringenin-chalcone synthase 2.3.1.75 Long-chain-alcohol O-fatty-acyltransferase 2.3.1.76 ... Tropine acyltransferase 2.3.1.186 Pseudotropine acyltransferase 2.3.1.187 Acetyl-S-ACP:malonate ACP transferase 2.3.1.188 Omega ... Sphingosine N-acyltransferase 2.3.1.25 Plasmalogen synthase 2.3.1.26 Sterol O-acyltransferase 2.3.1.27 Cortisol O- ...
more infohttps://enzyme.expasy.org/EC/2.-.-.-
Lysophospholipid acyltransferase LPCAT4  Lysophospholipid acyltransferase LPCAT4
Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ... Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; ... In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase ... Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of ...
more infohttps://pharos.nih.gov/idg/targets/Q643R3
Long-chain omega-3 fatty acids and cancer: any cause for concern?  Long-chain omega-3 fatty acids and cancer: any cause for concern?
Fat-1 Transgene is Associated with Improved Reproductive Outcomes.. High intake of omega-3 polyunsaturated fatty acids (PUFAs) ... 1-acylglycerophosphocholine O-acyltransferase. An enzyme localized predominantly within the plasma membrane of lymphocytes. It ... to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. EC 2.3.1.23. ...
more infohttps://www.bioportfolio.com/resources/pmarticle/1911822/Long-chain-omega-3-fatty-acids-and-cancer-any-cause-for-concern.html
Lpcat3 - Lysophospholipid acyltransferase 5 - Mus musculus (Mouse) - Lpcat3 gene & protein  Lpcat3 - Lysophospholipid acyltransferase 5 - Mus musculus (Mouse) - Lpcat3 gene & protein
Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as ... Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into ... 1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS ... 1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or ...
more infohttps://www.uniprot.org/uniprot/Q91V01
A survey of orphan enzyme activities | BMC Bioinformatics | Full Text  A survey of orphan enzyme activities | BMC Bioinformatics | Full Text
Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells. Proc Natl Acad Sci ... 2005, 33 (suppl 1): D154-159.PubMed CentralPubMedGoogle Scholar. *. Peterson JD, Umayam LA, Dickinson T, Hickey EK, White O: ... 2005, 6 (1): R2-10.1186/gb-2004-6-1-r2.PubMed CentralView ArticlePubMedGoogle Scholar. ... 2001, 29 (1): 123-125. 10.1093/nar/29.1.123.PubMed CentralView ArticlePubMedGoogle Scholar. ...
more infohttps://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-244
Lysolecithin acyltransferase - Wikipedia  Lysolecithin acyltransferase - Wikipedia
Lysolecithin acyltransferase may refer to: 1-acylglycerophosphocholine O-acyltransferase, an enzyme Phosphatidylcholine-sterol ...
more infohttps://en.wikipedia.org/wiki/Lysolecithin_acyltransferase
The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory...  The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory...
We also detail the pattern of expression and co-expression of two isoforms of lysophosphatidylcholine acyltransferase (LPCAT), ... Immunohistochemistry shows that both TLR4 and TLR7 preferentially co-localize with transient receptor potential vallinoid 1 ( ...
more infohttps://pearl.plymouth.ac.uk/handle/10026.1/8606
List of MeSH codes (D08) - Wikipedia  List of MeSH codes (D08) - Wikipedia
... phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050.646 --- retinol O-fatty-acyltransferase MeSH D08.811.913.050. ... diacylglycerol o-acyltransferase MeSH D08.811.913.050.425 --- glycerol-3-phosphate O-acyltransferase MeSH D08.811.913.050.600 ... acetyl-CoA C-acyltransferase MeSH D08.811.913.050.134 --- acetyltransferases MeSH D08.811.913.050.134.029 --- acyl-carrier ... sterol O-acyltransferase MeSH D08.811.913.200.324 --- acetolactate synthase MeSH D08.811.913.200.650 --- transaldolase MeSH ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
ENZYME: 2.3.1.  ENZYME: 2.3.1.
2-acylglycerophosphocholine O-acyltransferase 2.3.1.63 1-alkylglycerophosphocholine O-acyltransferase 2.3.1.64 Agmatine N(4)- ... sterol O-acyltransferase 2.3.1.74 Chalcone synthase 2.3.1.75 Long-chain-alcohol O-fatty-acyltransferase 2.3.1.76 Retinol O- ... Tropine acyltransferase 2.3.1.186 Pseudotropine acyltransferase 2.3.1.187 Acetyl-S-ACP:malonate ACP transferase 2.3.1.188 Omega ... Sphingosine N-acyltransferase 2.3.1.25 Plasmalogen synthase 2.3.1.26 Sterol O-acyltransferase 2.3.1.27 Cortisol O- ...
more infohttps://enzyme.expasy.org/EC/2.3.1.-
From emission sources to human tissues: modelling the exposure to per- and polyfluoroalkyl substances. Melissa Ines Gomis - PDF  From emission sources to human tissues: modelling the exposure to per- and polyfluoroalkyl substances. Melissa Ines Gomis - PDF
1): 20 [1] Where C serum (ng/ml) is the concentration of PFAS in serum, I (ng/day) is the intake of PFASs, E a (dimensionless) ... 31 Table 1: Summary of the modelling approach in Paper I, II and IV. Paper I Paper II Paper IV PFASs PFOS / PFHxS / PFOA PFOA ... ICH Topic S 1 A The Need for Carcinogenicity Studies of Pharmaceuticals. Step 5 European Medicines Agency July 1996 CPMP/ICH/ ... Table 1 summarizes the type of biomonitoring data and model used in the three studies as well as the PFASs and outputs that ...
more infohttp://docplayer.net/48146960-From-emission-sources-to-human-tissues-modelling-the-exposure-to-per-and-polyfluoroalkyl-substances-melissa-ines-gomis.html
PCAT1 Antibody (C-term) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IHC-P, FC, E - Buy Now! |Abgent  PCAT1 Antibody (C-term) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IHC-P, FC, E - Buy Now! |Abgent
PCAT1 acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to hosphatidylcholine (PC) in the remodeling pathway ... Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). Activity is calcium- ... LPC acyltransferase 1, LPCAT-1, LysoPC acyltransferase 1, 1-acylglycerophosphocholine O-acyltransferase, 1- ... Acyltransferase-like 2, Phosphonoformate immuno-associated protein 3, LPCAT1, AYTL2, PFAAP3. ...
more infohttps://www.abgent.com/products/AP9310b-PCAT1-Antibody-C-term
Anti-LPCAT1 antibody (ab94903) | Abcam  Anti-LPCAT1 antibody (ab94903) | Abcam
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the ... Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1- ... Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.. J Clin Invest 125:2808- ... Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell ...
more infohttp://www.abcam.com/lpcat1-antibody-ab94903.html
Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice. - Semantic Scholar  Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice. - Semantic Scholar
... leading to premature truncation of the lysophosphatidylcholine acyltransferase-1 (LPCAT1) protein. LPCAT1 (also called AYTL2) ... Subsequent screening of this gene in the B6-JR2845 strain revealed a seven-nucleotide deletion (c.14-20delGCCGCGG) in exon 1. ... Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive ... Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice.. @article{ ...
more infohttps://www.semanticscholar.org/paper/Loss-of-lysophosphatidylcholine-acyltransferase-1-Friedman-Chang/de7f868b4f0e782b7024c92621e3ed257c51fa25
KEGG BRITE: Enzymes - Mycobacterium tuberculosis H37Rv  KEGG BRITE: Enzymes - Mycobacterium tuberculosis H37Rv
2.3.1.62 2-acylglycerophosphocholine O-acyltransferase 2.3.1.63 1-alkylglycerophosphocholine O-acyltransferase ... 2.3.1.129 acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase 2.3.1.130 galactarate O- ...
more infohttp://www.genome.jp/kegg-bin/get_htext?mtu01000+Rv2243
Phosphatidylcholine-sterol o-acyltransferase | definition of Phosphatidylcholine-sterol o-acyltransferase by Medical dictionary  Phosphatidylcholine-sterol o-acyltransferase | definition of Phosphatidylcholine-sterol o-acyltransferase by Medical dictionary
What is Phosphatidylcholine-sterol o-acyltransferase? Meaning of Phosphatidylcholine-sterol o-acyltransferase medical term. ... Looking for online definition of Phosphatidylcholine-sterol o-acyltransferase in the Medical Dictionary? Phosphatidylcholine- ... lecithin-cholesterol acyltransferase. (redirected from Phosphatidylcholine-sterol o-acyltransferase) lec·i·thin-cho·les·ter·ol ... Synonym(s): lecithin acyltransferase. lecithin-cholesterol acyltransferase. /lec·i·thin-cho·les·ter·ol ac·yl·trans·fer·ase/ ( ...
more infohttp://medical-dictionary.thefreedictionary.com/Phosphatidylcholine-sterol+o-acyltransferase
National University Corporation Kyushu University - Research Output
     - Kyushu University  National University Corporation Kyushu University - Research Output - Kyushu University
Correction: Novel lysophospholipid acyltransferase plat1 of aurantiochytrium limacinum f26-b responsible for generation of ... Wada, M., Hiroshi, U. & Furue, M., Jan 1 2018, In : Nishinihon Journal of Dermatology. 80, 1, p. 1-2 2 p.. Research output: ... Miyazaki, R., Hiroshi, U. & Furue, M., Jan 1 2018, In : Nishinihon Journal of Dermatology. 80, 1, p. 3-4 2 p.. Research output ... Aoki, M., Shundo, A., Okamoto, K., Ganbe, T. & Tanaka, K., Mar 1 2019, In : Polymer Journal. 51, 3, p. 359-363 5 p.. Research ...
more infohttps://kyushu-u.pure.elsevier.com/en/organisations/national-university-corporation-kyushu-university/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fcomment
Reactome | GO MolecularFunction  Reactome | GO MolecularFunction
2-acylglycerol O-acyltransferase activity 82691 2-acylglycerol-3-phosphate O-acyltransferase activity ... 1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity 12590 (N-acetylneuraminyl)-galactosylglucosylceramide N- ... 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity 2161574 20-aldehyde-leukotriene B4 20-monooxygenase activity ... 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity 162298 2-hexaprenyl-6-methoxy-1,4-benzoquinone ...
more infohttp://reactome.ncpsb.org/content/schema/objects/GO_MolecularFunction
GLYAT (ACGNAT, CAT, GAT, Glycine N-acyltransferase, Acyl-CoA  GLYAT (ACGNAT, CAT, GAT, Glycine N-acyltransferase, Acyl-CoA
GLYAT ACGNAT CAT GAT Glycine N acyltransferase Acyl CoA glycine N acyltransferase Aralkyl acyl CoA N acyltransferase Aralkyl ... Gene targetGLYAT ACGNAT CAT GAT Glycine N-acyltransferase Acyl-CoA:glycine N-acyltransferase Aralkyl acyl-CoA N-acyltransferase ... GLYAT ACGNAT CAT GAT Glycine N acyltransferase Acyl CoA glycine N acyltransferase Aralkyl acyl CoA N acyltransferase Aralkyl ... GLYAT ACGNAT CAT GAT Glycine N acyltransferase Acyl CoA glycine N acyltransferase Aralkyl acyl CoA N acyltransferase Aralkyl ...
more infohttps://gentaur.com/964360279/glyat-acgnat-cat-gat-glycine-n/mybiosource?p=3025416325
Human Metabolome Database: Showing metabocard for PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (HMDB0007892)  Human Metabolome Database: Showing metabocard for PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) (HMDB0007892)
Phosphatidylcholine-sterol acyltransferase. General function:. Involved in phosphatidylcholine-sterol O-acyltransferase ... 2-acylglycerol O-acyltransferase 2. General function:. Involved in transferase activity, transferring acyl groups other than ... Lecithin retinol acyltransferase. General function:. Involved in phosphatidylcholine-retinol O-acyltransfera. Specific function ... Lysophospholipid acyltransferase 5. General function:. Involved in 1-acylglycerophosphocholine O-acyltransfera. Specific ...
more infohttp://www.hmdb.ca/metabolites/HMDB07892
  • Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. (nih.gov)
  • converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. (uniprot.org)
  • PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)), in particular, consists of one chain of myristic acid at the C-1 position and one chain of docosahexaenoic acid at the C-2 position. (hmdb.ca)
  • This thesis explores the human exposure to long-chain PFASs and their alternatives using different modelling methods and aims to 1) link comprehensively the past and current industrial production with the human body burden and 2) assess the potential hazardous properties of legacy PFASs replacements, on which information is very limited. (docplayer.net)
  • Starting from either 1-lysoPC or 2-lysoPC, an equilibrium mixture of 90% 2-lysoPC and 10% 1-lysoPC is obtained with a half-time of about 10 minutes under physiological conditions and about 1 hour under typical laboratory conditions. (wikipedia.org)
  • 1-LysoPC can convert to the structurally similar 2-lysoPC. (wikipedia.org)
  • Because 1-lysoPC has a relatively short half-life (see above), it is primarily a metabolic intermediate or side-product in the formation or breakdown of other lipids. (wikipedia.org)