Phosphatidic Acids
Acyltransferases
Lipase
Glycerol-3-Phosphate O-Acyltransferase
Fatty Acids
Phosphatidylcholine-Sterol O-Acyltransferase
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.
Diacylglycerol O-Acyltransferase
Sterol O-Acyltransferase
Lecithin Acyltransferase Deficiency
An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.
1-Acylglycerophosphocholine O-Acyltransferase
Acyl Coenzyme A
1-Acylglycerol-3-Phosphate O-Acyltransferase
Calcium Phosphates
Glucose-6-Phosphate
Glyceraldehyde-3-Phosphate Dehydrogenases
Esterification
The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.
Cholesterol Esters
Escherichia coli O157
A verocytotoxin-producing serogroup belonging to the O subfamily of Escherichia coli which has been shown to cause severe food-borne disease. A strain from this serogroup, serotype H7, which produces SHIGA TOXINS, has been linked to human disease outbreaks resulting from contamination of foods by E. coli O157 from bovine origin.
Substrate Specificity
Microsomes
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Inositol Phosphates
Cholesterol
Apolipoprotein A-I
The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.
Lysophospholipids
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Phosphatidylcholines
Retinol O-Fatty-Acyltransferase
Palmitoyl Coenzyme A
Amino Acid Sequence
Glyceraldehyde 3-Phosphate
Liver
Pentose Phosphate Pathway
An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
Lipoproteins, HDL
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
Carnitine Acyltransferases
Microsomes, Liver
Phosphate Transport Proteins
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
O(6)-Methylguanine-DNA Methyltransferase
Glucose-6-Phosphate Isomerase
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Lysophosphatidylcholines
Hydrogen-Ion Concentration
Lipid Metabolism
Waxes
A plastic substance deposited by insects or obtained from plants. Waxes are esters of various fatty acids with higher, usually monohydric alcohols. The wax of pharmacy is principally yellow wax (beeswax), the material of which honeycomb is made. It consists chiefly of cerotic acid and myricin and is used in making ointments, cerates, etc. (Dorland, 27th ed)
Lipoproteins
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
Hypolipoproteinemias
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Lysophospholipase
Sphingosine
Cloning, Molecular
Base Sequence
Corneal Opacity
Carbamyl Phosphate
Mutation
Apolipoproteins
Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.
Dithionitrobenzoic Acid
Phosphate-Binding Proteins
Oleic Acids
Sequence Homology, Amino Acid
Apolipoproteins A
Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.
Phosphotransferases
Rats, Inbred Strains
Oleic Acid
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Binding Sites
Transferases (Other Substituted Phosphate Groups)
Phosphatidylinositol Phosphates
Organophosphates
Carbon-containing phosphoric acid derivatives. Included under this heading are compounds that have CARBON atoms bound to one or more OXYGEN atoms of the P(=O)(O)3 structure. Note that several specific classes of endogenous phosphorus-containing compounds such as NUCLEOTIDES; PHOSPHOLIPIDS; and PHOSPHOPROTEINS are listed elsewhere.
Mitochondria, Liver
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
Cell Membrane
Chromatography, Thin Layer
Palmitoyl-CoA Hydrolase
Lipid A
Glycerol
Aldehyde-Lyases
Vitamin A
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Receptors, Lysosphingolipid
Receptor, IGF Type 2
Electrophoresis, Polyacrylamide Gel
Rabbits
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Phosphoric Monoester Hydrolases
Gene Expression Regulation, Enzymologic
Acyl Carrier Protein
Microbodies
Seeds
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Adenosine Triphosphate
Octoxynol
Enzyme Activation
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Molecular Structure
Saccharomyces cerevisiae
Phosphotransferases (Alcohol Group Acceptor)
Malonyl Coenzyme A
Phospholipases
Magnetic Resonance Spectroscopy
Enzyme Inhibitors
Cricetinae
Subcellular Fractions
Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)
Glucose
Structure-Activity Relationship
Multienzyme Complexes
Organophosphorus Compounds
Chromatography, Gel
Chromatography, High Pressure Liquid
Cattle
Polyketide Synthases
Protein Binding
Penicillium
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Models, Molecular
Carbon Radioisotopes
Polyethylene Glycols
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
Sterol Esterase
Carrier Proteins
Magnesium
Temperature
Hydroxymethylglutaryl CoA Reductases
Lipoprotein-X
An abnormal lipoprotein present in large amounts in patients with obstructive liver diseases such as INTRAHEPATIC CHOLESTASIS. LP-X derives from the reflux of BILE lipoproteins into the bloodstream. LP-X is a low-density lipoprotein rich in free CHOLESTEROL and PHOSPHOLIPIDS but poor in TRIGLYCERIDES; CHOLESTEROL ESTERS; and protein.
Biological Transport
Cells, Cultured
Phosphatidate Phosphatase
Caprylates
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Isoenzymes
Catalysis
Lipoproteins, LDL
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
DNA, Complementary
Glucosephosphate Dehydrogenase Deficiency
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Phosphatidylinositols
Apolipoprotein A-II
The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.
NADP
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Arachis hypogaea
Arabidopsis
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Phosphorus
Acetates
Cholesterol Ester Transfer Proteins
UTP-Hexose-1-Phosphate Uridylyltransferase
Acetyl-CoA C-Acetyltransferase
Plasmalogens
Deoxycholic Acid
Phosphatidylethanolamines
Solubility
Enzyme Assays
Methods used to measure the relative activity of a specific enzyme or its concentration in solution. Typically an enzyme substrate is added to a buffer solution containing enzyme and the rate of conversion of substrate to product is measured under controlled conditions. Many classical enzymatic assay methods involve the use of synthetic colorimetric substrates and measuring the reaction rates using a spectrophotometer.
Glycerylphosphorylcholine
Palmitic Acid
Myo-Inositol-1-Phosphate Synthase
Sterols
Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
Cardiolipins
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
Mortierella
Lipoproteins, VLDL
A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.
Gene Expression
Sodium-Phosphate Cotransporter Proteins
Detergents
Fatty Alcohols
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Models, Chemical
Acetyltransferases
A plastidial lysophosphatidic acid acyltransferase from oilseed rape. (1/111)
The biosynthesis of phosphatidic acid, a key intermediate in the biosynthesis of lipids, is controlled by lysophosphatidic acid (LPA, or 1-acyl-glycerol-3-P) acyltransferase (LPAAT, EC 2.3.1.51). We have isolated a cDNA encoding a novel LPAAT by functional complementation of the Escherichia coli mutant plsC with an immature embryo cDNA library of oilseed rape (Brassica napus). Transformation of the acyltransferase-deficient E. coli strain JC201 with the cDNA sequence BAT2 alleviated the temperature-sensitive phenotype of the plsC mutant and conferred a palmitoyl-coenzyme A-preferring acyltransferase activity to membrane fractions. The BAT2 cDNA encoded a protein of 351 amino acids with a predicted molecular mass of 38 kD and an isoelectric point of 9.7. Chloroplast-import experiments showed processing of a BAT2 precursor protein to a mature protein of approximately 32 kD, which was localized in the membrane fraction. BAT2 is encoded by a minimum of two genes that may be expressed ubiquitously. These data are consistent with the identity of BAT2 as the plastidial enzyme of the prokaryotic glycerol-3-P pathway that uses a palmitoyl-ACP to produce phosphatidic acid with a prokaryotic-type acyl composition. The homologies between the deduced protein sequence of BAT2 with prokaryotic and eukaryotic microsomal LAP acytransferases suggest that seed microsomal forms may have evolved from the plastidial enzyme. (+info)Overexpression of 1-acyl-glycerol-3-phosphate acyltransferase-alpha enhances lipid storage in cellular models of adipose tissue and skeletal muscle. (2/111)
Plasma nonesterified fatty acids (NEFA) at elevated concentrations antagonize insulin action and thus may play a critical role in the development of insulin resistance in type 2 diabetes. Plasma NEFA and glucose concentrations are regulated, in part, by their uptake into peripheral tissues. Cellular energy uptake can be increased by enhancing either energy transport or metabolism. The effects of overexpression of 1-acylglycerol-3-phosphate acyltransferase (AGAT)-alpha, which catalyzes the second step in triglyceride formation from glycerol-3-phosphate, was studied in 3T3-L1 adipocytes and C2C12 myotubes. In myotubes, overexpression of AGAT-alpha did not affect total [14C]glucose uptake in the presence or absence of insulin, whereas insulin-stimulated [14C]glucose conversion to cellular lipids increased significantly (33%, P = 0.004) with a concomitant decrease (-30%, P = 0.005) in glycogen formation. [3H]oleic acid (OA) uptake in AGAT-overexpressing myotubes increased 34% (P = 0.027) upon insulin stimulation. AGAT-alpha overexpression in adipocytes increased basal (130%, P = 0.04) and insulin-stimulated (27%, P = 0.01) [3H]OA uptake, increased insulin-stimulated glucose uptake (56%, P = 0.04) and conversion to cellular lipids (85%, P = 0.007), and suppressed basal (-44%, P = 0.01) and isoproterenol-stimulated OA release (-45%, P = 0.03) but not glycerol release. Our data indicate that an increase in metabolic flow to triglyceride synthesis can inhibit NEFA release, increase NEFA uptake, and promote insulin-mediated glucose utilization in 3T3-L1 adipocytes. In myotubes, however, AGAT-alpha overexpression does not increase basal cellular energy uptake, but can enhance NEFA uptake and divert glucose from glycogen synthesis to lipogenesis upon insulin stimulation. (+info)Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome. (3/111)
Chanarin-Dorfman syndrome (CDS) is a rare autosomal recessive form of nonbullous congenital ichthyosiform erythroderma (NCIE) that is characterized by the presence of intracellular lipid droplets in most tissues. We previously localized a gene for a subset of NCIE to chromosome 3 (designated "the NCIE2 locus"), in six families. Lipid droplets were found in five of these six families, suggesting a diagnosis of CDS. Four additional families selected on the basis of a confirmed diagnosis of CDS also showed linkage to the NCIE2 locus. Linkage-disequilibrium analysis of these families, all from the Mediterranean basin, allowed us to refine the NCIE2 locus to an approximately 1.3-Mb region. Candidate genes from the interval were screened, and eight distinct mutations in the recently identified CGI-58 gene were found in 13 patients from these nine families. The spectrum of gene variants included insertion, deletion, splice-site, and point mutations. The CGI-58 protein belongs to a large family of proteins characterized by an alpha/beta hydrolase fold. CGI-58 contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. Interestingly, CGI-58 differs from other members of the esterase/lipase/thioesterase subfamily in that its putative catalytic triad contains an asparagine in place of the usual serine residue. (+info)Exploration of novel motifs derived from mouse cDNA sequences. (4/111)
We performed a systematic maximum density subgraph (MDS) detection of conserved sequence regions to discover new, biologically relevant motifs from a set of 21,050 conceptually translated mouse cDNA (FANTOM1) sequences. A total of 3202 candidate sequences, which shared similar regions over >20 amino acid residues, were screened against known conserved regions listed in Pfam, ProDom, and InterPro. The filtering procedure resulted in 139 FANTOM1 sequences belonging to 49 new motif candidates. Using annotations and multiple sequence alignment information, we removed by visual inspection 42 candidates whose members were found to be false positives because of sequence redundancy, alternative splicing, low complexity, transcribed retroviral repeat elements contained in the region of the predicted open reading frame, and reports in the literature. The remaining seven motifs have been expanded by hidden Markov model (HMM) profile searches of SWISS-PROT/TrEMBL from 28 FANTOM1 sequences to 164 members and analyzed in detail on sequence and structure level to elucidate the possible functions of motifs and members. The novel and conserved motif MDS00105 is specific for the mammalian inhibitor of growth (ING) family. Three submotifs MDS00105.1-3 are specific for ING1/ING1L, ING1-homolog, and ING3 subfamilies. The motif MDS00105 together with a PHD finger domain constitutes a module for ING proteins. Structural motif MDS00113 represents a leucine zipper-like motif. Conserved motif MDS00145 is a novel 1-acyl-SN-glycerol-3-phosphate acyltransferase (AGPAT) submotif containing a transmembrane domain that distinguishes AGPAT3 and AGPAT4 from all other acyltransferase domain-containing proteins. Functional motif MDS00148 overlaps with the kazal-type serine protease inhibitor domain but has been detected only in an extracellular loop region of solute carrier 21 (SLC21) (organic anion transporters) family members, which may regulate the specificity of anion uptake. Our motif discovery not only aided in the functional characterization of new mouse orthologs for potential drug targets but also allowed us to predict that at least 16 other new motifs are waiting to be discovered from the current SWISS-PROT/TrEMBL database. (+info)Limnanthes douglasii lysophosphatidic acid acyltransferases: immunological quantification, acyl selectivity and functional replacement of the Escherichia coli plsC gene. (5/111)
Antibodies were raised against the two membrane-bound lysophosphatidic acid acyltransferase (LPAAT) enzymes from Limnanthes douglasii (meadowfoam), LAT1 and LAT2, using the predicted soluble portion of each protein as recombinant protein antigens. The antibodies can distinguish between the two acyltransferase proteins and demonstrate that both migrate in an anomalous fashion on SDS/PAGE gels. The antibodies were used to determine that LAT1 is present in both leaf and developing seeds, whereas LAT2 is only detectable in developing seeds later than 22 daf (days after flowering). Both proteins were found exclusively in microsomal fractions and their amount was determined using the recombinant antigens as quantification standards. LAT1 is present at a level of 27 pg/microg of membrane protein in leaf tissue andPrevalence of mutations in AGPAT2 among human lipodystrophies. (6/111)
Berardinelli-Seip congenital lipodystrophy (BSCL) is a heterogeneous genetic disease characterized by near absence of adipose tissue and severe insulin resistance. We have previously identified mutations in the seipin gene in a subset of our patients' cohort. Recently, disease-causing mutations in AGPAT2 have been reported in BSCL patients. In this study, we have performed mutation screening in AGPAT2 and the related AGPAT1 in patients with BSCL or other forms of lipodystrophy who have no detectable mutation in the seipin gene. We found 38 BSCL patients from 30 families with mutations in AGPAT2. Three of the known mutations were frequently found in our families. Of the eight new alterations, six are null mutations and two are missense mutations (Glu172Lys and Ala238Gly). All the patients harboring AGPAT2 mutations presented with typical features of BSCL. We did not find mutations in patients with other forms of lipodystrophies, including the syndromes of Lawrence, Dunnigan, and Barraquer-Simons, or with type A insulin resistance. In conclusion, mutations in the seipin gene and AGPAT2 are confined to the BSCL phenotype. Because we found mutations in 92 of the 94 BSCL patients studied, the seipin gene and AGPAT2 are the two major genes involved in the etiology of BSCL. (+info)Truncation of CGI-58 protein causes malformation of lamellar granules resulting in ichthyosis in Dorfman-Chanarin syndrome. (7/111)
Dorfman-Chanarin syndrome is a rare autosomal recessive inherited lipid storage disease characterized by ichthyosis, leukocyte lipid vacuoles, and involvement of several internal organs. Recently, CGI-58 mutations were identified as the cause of Dorfman-Chanarin syndrome. The physiologic roles of the CGI-58 protein and the pathomechanisms of Dorfman-Chanarin syndrome still remain to be clarified, however. The patient, a 16-y-old male, demonstrated ichthyosis, small ears, lipid vacuoles in his leukocytes, liver dysfunction, and mental retardation. Sequencing of CGI-58 revealed that the patient was homozygous for a novel nonsense mutation R184X, in exon 4. The putative truncated protein was 52.4% of the length of the normal CGI-58 polypeptide and lacked approximately 60% of the lipid binding region, 66.4% of the alpha/beta hydrolase folding segment of the polypeptide, and two of the CGI-58 catalytic triads, resulting in a significant loss of lipase/esterase/thioesterase activity. Electron microscopy revealed a large number of abnormal lamellar granules, a disturbed intercellular lamellar structure, and lipid vacuoles in the epidermis. These results suggested that CGI-58 protein is involved in the lipid metabolism of lamellar granules and that defective lipid production in lamellar granules caused by a CGI-58 protein deficiency is involved in the pathogenesis of ichthyosis in Dorfman-Chanarin syndrome. (+info)CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. (8/111)
Lipid droplets (LDs) are a class of ubiquitous cellular organelles that are involved in lipid storage and metabolism. Although the mechanisms of the biogenesis of LDs are still unclear, a set of proteins called the PAT domain family have been characterized as factors associating with LDs. Perilipin, a member of this family, is expressed exclusively in the adipose tissue and regulates the breakdown of triacylglycerol in LDs via its phosphorylation. In this study, we used a yeast two-hybrid system to examine the potential function of perilipin. We found direct interaction between perilipin and CGI-58, a deficiency of which correlated with the pathogenesis of Chanarin-Dorfman syndrome (CDS). Endogenous CGI-58 was distributed predominantly on the surface of LDs in differentiated 3T3-L1 cells, and its expression increased during adipocyte differentiation. Overexpressed CGI-58 tagged with GFP gathered at the surface of LDs and colocalized with perilipin. This interaction seems physiologically important because CGI-58 mutants carrying an amino acid substitution identical to that found in CDS lost the ability to be recruited to LDs. These mutations significantly weakened the binding of CGI-58 with perilipin, indicating that the loss of this interaction is involved in the etiology of CDS. Furthermore, we identified CGI-58 as a binding partner of ADRP, another PAT domain protein expressed ubiquitously, by yeast two-hybrid assay. GFP-CGI-58 expressed in non-differentiated 3T3-L1 or CHO-K1 cells was colocalized with ADRP, and the CGI-58 mutants were not recruited to LDs carrying ADRP, indicating that CGI-58 may also cooperate with ADRP. (+info)
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Mutagenesis of a plastidial lysophosphatidic acid acyltransferase | Biochemical Society Transactions
Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase | Science
New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase...
eCite - Phosphorylation of adipose triglyceride lipase Ser(404) is not related to 5-AMPK activation during moderate-intensity...
Sterol O-Acyltransferase financial definition of Sterol O-Acyltransferase
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Phosphatidylcholine-sterol o-acyltransferase: Definition with Phosphatidylcholine-sterol o-acyltransferase Pictures and Photos
ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system
Cardiomyocyte steatosis and defective washout of iodine-123-β-methyl iodophenyl-pentadecanoic acid in genetic deficiency of...
ABHD12 cdna clone product blog
AbnovaHuman AGPAT1 Full-length ORF (NP 006402.1, 1 a.a. - 283 a.a.) Recombinant
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ABHD9 polyclonal antibody - (PAB21930) - Products - Abnova
Tissue expression of ABHD12 - Staining in kidney - The Human Protein Atlas
Expression of ABHD17B in cancer - Summary - The Human Protein Atlas
Mutation in the ABHD12 Gene Causes & Reasons - Symptoma
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AGPAT3
Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases". Front. Biosci. 6: D944-53. doi: ... The protein encoded by this gene is an acyltransferase (specifically, 1-acylglycerol-3-phosphate O-acyltransferase) that ... 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015. van der Weyden L, White JK, Adams DJ, Logan DW ( ... 449 (1-2): 64-76. doi:10.1016/j.abb.2006.03.014. PMID 16620771. Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based ...
AGPAT2
Aguado B, Campbell RD (Feb 1998). "Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene ... Eberhardt C, Gray PW, Tjoelker LW (Aug 1997). "Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and ... lysophosphatidic acid acyltransferase, beta)". Human AGPAT2 genome location and AGPAT2 gene details page in the UCSC Genome ... "A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases". The Biochemical Journal. 326 (2 ...
AGPAT5
... lysophosphatidic acid acyltransferase, epsilon)". Human AGPAT5 genome location and AGPAT5 gene details page in the UCSC Genome ... 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene. This gene ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Lu B, Jiang YJ, Zhou Y, et al. (2005). "Cloning and characterization of murine ... 449 (1-2): 64-76. doi:10.1016/j.abb.2006.03.014. PMID 16620771. v t e (Articles with short description, Short description ...
AGPAT1
Aguado B, Campbell RD (Mar 1998). "Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene ... Aguado B, Campbell RD (1998). "Human lysophosphatidic acid acyltransferase is encoded by a gene located in the major ... Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases". Front. Biosci. 6 (1): D944-53. ... 1997). "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling ...
AGPAT9
2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. ... acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo ... lysophosphatidic acid acyltransferase theta (LPAAT-theta), or lung cancer metastasis-associated protein 1. Glycerol-3-phosphate ... "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. ...
ABHD5
236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY ... 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015. van der Weyden L, White JK, Adams DJ, Logan DW ( ... 3 (5): 309-19. doi:10.1016/j.cmet.2006.03.005. PMID 16679289. Yamaguchi T, Omatsu N, Morimoto E, Nakashima H, Ueno K, Tanaka T ... 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 is an enzyme that in humans is encoded by the ABHD5 gene. The protein ...
Congenital generalized lipodystrophy
More recently, type 3 CGL was identified as a separate type of CGL, which was identified as a mutation in the CAV1 gene. Then, ... Type 3 CGL involves a mutation in the CAV1 gene. This gene codes for the Caveolin protein, which is a scaffolding membrane ... Types 3 and 4 are two different mutations but they share a common defective pathway. Medical diagnosis of CGL can be made after ... In type 1 patients, they still have mechanical adipose tissue, but type 2 patients do not have any adipose tissue, including ...
Chromosome 4
ISBN 978-1-136-84407-2. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last ... ISBN 978-1-4673-1921-8. S2CID 16666470. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly ... ISBN 978-3-318-02253-7. Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. ( ... 329 (5999): 1650-3. Bibcode:2010Sci...329.1650L. doi:10.1126/science.1189044. PMC 4677822. PMID 20724583. Genome Decoration ...
Glycerol-3-phosphate O-acyltransferase
... glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... Yamashita S, Numa S (1972). "Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation ... Other names in common use include alpha-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3 ...
2-acylglycerol-3-phosphate O-acyltransferase
In enzymology, a 2-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.52) is an enzyme that catalyzes the chemical reaction ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... This enzyme is also called 2-acylglycerophosphate acyltransferase. This enzyme participates in glycerophospholipid metabolism. ... 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. ...
1-acylglycerol-3-phosphate O-acyltransferase
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, ... 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. ... 38 (1): 25-31. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123. Portal: Biology v t e (EC 2.3.1, Enzymes of unknown ...
List of MeSH codes (D08)
... glucose-6-phosphate isomerase MeSH D08.811.399.475.200.550 - mannose-6-phosphate isomerase MeSH D08.811.399.475.200.662 - ... phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050.646 - retinol O-fatty-acyltransferase MeSH D08.811.913.050. ... nucleoside-phosphate kinase MeSH D08.811.913.696.900 - transferases (other substituted phosphate groups) MeSH D08.811.913.696. ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 - carbon-nitrogen ligases with glutamine as amide-n-donor MeSH ...
Phosphatidic acid
PA is a vital cell lipid that acts as a biosynthetic precursor for the formation (directly or indirectly) of all acylglycerol ... This will show whether the phosphate group is newly derived from the kinase activity or whether it originates from the PC. ... Different acyltransferases also have different intracellular distributions, such as the endoplasmic reticulum (ER), the ... This suggests that the various acyltransferases present in mammalian and yeast cells may be responsible for producing different ...
List of EC numbers (EC 2)
... diacylglycerol O-acyltransferase EC 2.3.1.21: carnitine O-palmitoyltransferase EC 2.3.1.22: 2-acylglycerol O-acyltransferase EC ... glycerone-phosphate O-acyltransferase EC 2.3.1.43: phosphatidylcholine-sterol O-acyltransferase EC 2.3.1.44: N- ... phosphate acyltransferase (*) EC 2.3.1.275: acyl phosphate:glycerol-3-phosphate acyltransferase (*) EC 2.3.1.276: galactosamine ... isopentenyl phosphate kinase EC 2.7.4.27: [pyruvate, phosphate dikinase]-phosphate phosphotransferase EC 2.7.4.28: [pyruvate, ...
Cardiolipin
Then acylglycerol-3-phosphate can be once more acylated to form a phosphatidic acid (PA). With the help of the enzyme CDP-DAG ... Since there are two phosphates in the molecule, each of them can catch one proton. Although it has a symmetric structure, ... The hydroxyl groups (-OH and -O−) on phosphate would form a stable intramolecular hydrogen bond with the centered glycerol's ... ionizing one phosphate happens at a very different levels of acidity than ionizing both: pK1 = 3 and pK2 > 7.5. So under normal ...
1-Lysophosphatidylcholine
In contrast to these finding from rat liver microsomes, mammalian acyl transferase from dog lungs was found to exhibit no ... 2-acylglycerophosphocholine O-acyltransferase, an enzyme purified in liver microsomes, catalyzes specifically the acylation of ... M. F. Frosolono; Slivka, S; Charms, BL (1971-01-01). "Acyl transferase activities in dog lung microsomes". Journal of Lipid ... Yamashita, A.; Sugiura, T.; Waku, K. (Jul 1997). "Acyltransferases and transacylases involved in fatty acid remodeling of ...
AGPAT2 gene: MedlinePlus Genetics
Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease. Curr Opin Lipidol ... 1-acyl-sn-glycerol-3-phosphate acyltransferase beta. *1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid ... The AGPAT2 gene mutations that cause congenital generalized lipodystrophy type 1 greatly reduce or eliminate the activity of ... 2002 May;31(1):21-3. doi: 10.1038/ng880. Epub 2002 Apr 22. Citation on PubMed ...
MedlinePlus: Genes
ABHD5: abhydrolase domain containing 5, lysophosphatidic acid acyltransferase. *ABL1: ABL proto-oncogene 1, non-receptor ... AGPS: alkylglycerone phosphate synthase. *AGT: angiotensinogen. *AGTR1: angiotensin II receptor type 1 ... ADAMTS2: ADAM metallopeptidase with thrombospondin type 1 motif 2. *ADAMTS10: ADAM metallopeptidase with thrombospondin type 1 ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
Dermatologic Manifestations of Generalized Lipodystrophy: Practice Essentials, Pathophysiology, Epidemiology
1] In 1959, Seip described a similar congenital syndrome, but without diabetes mellitus, in 3 young Norwegian children. Two of ... Over the next 3 years, a complete generalized loss of subcutaneous fat developed that began focally in the lower extremities. ... The 3 patients exhibited rapid growth with advanced bone age, dilation of the cerebral ventricles, hepatosplenomegaly with ... Related articles include Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Acanthosis Nigricans, Dermatologic Manifestations ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
MedlinePlus: Genes
ABHD5: abhydrolase domain containing 5, lysophosphatidic acid acyltransferase. *ABL1: ABL proto-oncogene 1, non-receptor ... AGPS: alkylglycerone phosphate synthase. *AGT: angiotensinogen. *AGTR1: angiotensin II receptor type 1 ... ADAMTS2: ADAM metallopeptidase with thrombospondin type 1 motif 2. *ADAMTS10: ADAM metallopeptidase with thrombospondin type 1 ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
Dermatologic Manifestations of Generalized Lipodystrophy: Practice Essentials, Pathophysiology, Epidemiology
1] In 1959, Seip described a similar congenital syndrome, but without diabetes mellitus, in 3 young Norwegian children. Two of ... Over the next 3 years, a complete generalized loss of subcutaneous fat developed that began focally in the lower extremities. ... The 3 patients exhibited rapid growth with advanced bone age, dilation of the cerebral ventricles, hepatosplenomegaly with ... Related articles include Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Acanthosis Nigricans, Dermatologic Manifestations ...
Code System Concept
1-acylglycerol-3-phosphate acyltransferase Current Synonym true false 76623018 1-Acylglycerol-3-phosphate acyltransferase ... 1-acylglycerol-3-phosphate acyltransferase (substance). Code System Preferred Concept Name. 1-acylglycerol-3-phosphate ... acyltransferase (substance). Concept Status. Published. Concept Status Date. 09/01/2020. Code System Name. SNOMED-CT ...
Code System Concept
Acylglycerol kinase (substance) {78232003 , SNOMED-CT } Acyl-phosphate-hexose phosphotransferase (substance) {79166007 , SNOMED ... Ecdysone O-acyltransferase (substance) {130303005 , SNOMED-CT } Erythritol kinase (substance) {13501003 , SNOMED-CT } ... Thiamin-phosphate kinase (substance) {64026007 , SNOMED-CT } Thiamin-phosphate pyrophosphorylase (substance) {69459001 , SNOMED ... acetyl-coenzyme A carboxylase) kinase (substance) {889006 , SNOMED-CT } (deoxy)nucleoside phosphate kinase (substance) { ...
1-acylglycerol-3-phosphate O-acyltransferase - Wikipedia
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, ... 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. ... 38 (1): 25-31. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123. Portal: Biology v t e (EC 2.3.1, Enzymes of unknown ...
Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) [Mus musculus (house...
enables acyltransferase activity IBA Inferred from Biological aspect of Ancestor. more info ... acts_upstream_of_or_within acylglycerol metabolic process IDA Inferred from Direct Assay. more info ... LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like. pfam16076. ... Acts upstream of or within acylglycerol metabolic process and hematopoietic progenitor cell differentiation. Located in ...
AGPAT2 gene: MedlinePlus Genetics
Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease. Curr Opin Lipidol ... 1-acyl-sn-glycerol-3-phosphate acyltransferase beta. *1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid ... The AGPAT2 gene mutations that cause congenital generalized lipodystrophy type 1 greatly reduce or eliminate the activity of ... 2002 May;31(1):21-3. doi: 10.1038/ng880. Epub 2002 Apr 22. Citation on PubMed ...
Dermatologic Manifestations of Generalized Lipodystrophy: Practice Essentials, Pathophysiology, Epidemiology
1] In 1959, Seip described a similar congenital syndrome, but without diabetes mellitus, in 3 young Norwegian children. Two of ... Over the next 3 years, a complete generalized loss of subcutaneous fat developed that began focally in the lower extremities. ... The 3 patients exhibited rapid growth with advanced bone age, dilation of the cerebral ventricles, hepatosplenomegaly with ... Related articles include Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Acanthosis Nigricans, Dermatologic Manifestations ...
MMRRC:038471-MU
3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when ... 1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The ... Name: actin-binding LIM protein 1. Synonyms: Limab1, 4833406P10Rik, abLIM-S, abLIM-M, abLIM-L, 2610209L21Rik, 9330196J19Rik, ... Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3. Synonyms: 3830408D16Rik, D4Ertd321e, Af9, 2210011H10Rik, ...
GenAge Human Genes: List of Entries
diacylglycerol O-acyltransferase 1. 0. 1. DLL3. 225. delta-like 3 (Drosophila). 12. 0. ... somatostatin receptor 3. 2. 2. STAT3. 22. signal transducer and activator of transcription 3 (acute-phase response factor). 13 ... complement component 1, q subcomponent, A chain. 1. 2. CACNA1A. 133. calcium channel, voltage-dependent, P/Q type, alpha 1A ... phosphoenolpyruvate carboxykinase 1 (soluble). 2. 8. PCMT1. 162. protein-L-isoaspartate (D-aspartate) O-methyltransferase. 5. ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in...
... glucose-6-phosphate (G-6-P) and fructose-6-phosphate (F-6-P) (Fig. 3b). These findings indicated that nitrogen deprivation ... 5e). We found that peroxisomal 2,4-dienoyl-CoA reductase (DECR2) and acetyl-CoA acyltransferase 1 (ACAA1), which play an ... d-Glucose-6-Phosphate, F-6-P, d-Fructose-6-Phosphate, PEP, Phosphoenolpyruvic acid, Pyr, Pyruvic acid, E-4-P, Erythrose-4- ... Systems analysis of phosphate-limitation-induced lipid accumulation by the oleaginous yeast Rhodosporidium toruloides. ...
Mammalian Diacylglycerol Acyltransferases (DGAT)
Acylglycerol Lipases (Neutral Lipid Hydrolysis) *Metabolism and Function of Very-Long-Chain Polyunsaturated Fatty Acids (,C24) ... retinol acyltransferase (ARAT) activities [13]. The relevance of these additional acyltransferase activities in vivo is not ... Mammalian Diacylglycerol Acyltransferases (DGAT). The Author: Scot J. Stone, Department of Biochemistry, Room 14.1 Health ... DGAT1 belongs to a large family of membrane-bound O-acyltransferases (MBOAT) and was initially discovered by its homology to ...
Code System Concept
1-acylglycerol-3-phosphate acyltransferase Current Synonym true false 76623018 1-Acylglycerol-3-phosphate acyltransferase ... 1-acylglycerol-3-phosphate acyltransferase (substance). Code System Preferred Concept Name. 1-acylglycerol-3-phosphate ... acyltransferase (substance). Concept Status. Published. Concept Status Date. 09/01/2020. Code System Name. SNOMED-CT ...
Green Center For Systems Biology - Research output - University of Texas Southwestern Medical Center
Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 2009, In: Journal of lipid research. 50, 3, p. 412-423 12 p.. Research output: ... Wang, J., Hou, T. & Xu, X., Mar 23 2009, In: Journal of Chemical Information and Modeling. 49, 3, p. 571-581 11 p.. Research ... Levine, B. & Ranganathan, R., Jul 1 2010, In: Nature. 466, 7302, p. 38-40 3 p.. Research output: Contribution to journal › ... Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. ...
Bio2Vec
ScienceSlides: Browse Tags A-Z
DisGeNET - a database of gene-disease associations
lysophosphatidylglycerol acyltransferase 1 6 0.890. 0.115. 0.98. 0.100. None 1.000. 1 1 2013. 2013. ... polycystin 2 like 1, transient receptor potential cation channel Ion channel 124 0.565. 0.731. 1.6E-27. 0.100. None 1.000. 2 1 ... RNA binding fox-1 homolog 1 Nucleic acid binding 103 0.584. 0.692. 0.95. 0.100. None 1.000. 2 2 2008. 2012. ... aldehyde dehydrogenase 1 family member A2 Enzyme 109 0.578. 0.692. 0.36. 0.100. None 1.000. 2 2 2008. 2012. ...
YJR139C 267.488705 INESSENTIAL HOM6 "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase),5-amino-6-(5...
... "inorganic phosphate transporter, transmembrane protein, phosphate transport, inorganic phosphate transporter, integral plasma ... "Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase),sterol O-acyltransferase," YDL018C 15.120823 INESSENTIAL ERP3 " ... "dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase, O-linked glycosylation, dolichyl-phosphate-mannose--protein ... "dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase, O-linked glycosylation, dolichyl-phosphate-mannose--protein ...
abnormal epididymal fat pad morphology - Ontology Report - Rat Genome Database
glycerol phosphate dehydrogenase 2, mitochondrial. IAGP. MGI. PMID:12093799. NCBI chr 2:57,127,690...57,260,731 Ensembl chr 2: ... phospholipase A and acyltransferase 3. IAGP. MGI. PMID:19136964. NCBI chr19:7,534,824...7,565,910 Ensembl chr19:7,534,824... ... phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma. IAGP. MGI. PMID:26100075. NCBI chr 6:139,591,070... ... hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). IAGP. MGI. PMID:31696216. NCBI chr 4:150,063,931...150,093,480 ...
IMP: Integrative Multi-species Prediction
... lysophosphatidic acid acyltransferase, alpha). 0.016. ... phosphatidylinositol-4-phosphate 5-kinase, type I, gamma. 0.018 ... hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor). 0.021. ... solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1). 0.015. ... fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor). 0.249. ...
Phosphatidylcholine-Sterol O-Acyltransferase | Harvard Catalyst Profiles | Harvard Catalyst
Phosphatidylcholine-Sterol O-Acyltransferase*Phosphatidylcholine-Sterol O-Acyltransferase. *O-Acyltransferase, ... "Phosphatidylcholine-Sterol O-Acyltransferase" is a descriptor in the National Library of Medicines controlled vocabulary ... In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of ... This graph shows the total number of publications written about "Phosphatidylcholine-Sterol O-Acyltransferase" by people in ...
ExplorEnz: EC 2.3.1.15
... glycerol phosphate acyltransferase; glycerol phosphate transacylase; glycerophosphate acyltransferase; glycerophosphate ... α-glycerophosphate acyltransferase; 3-glycerophosphate acyltransferase; ACP:sn-glycerol-3-phosphate acyltransferase; glycerol 3 ... Yamashita, S. and Numa, N. Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of ... O-acyltransferase. Comments:. Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of ...
mirbern
July 3, 2018. June 14, 2019. Categories Summer Research 2018, Uncategorized Week 4: Cleaning up. With our big CNB-MAC paper ... You randomly choose the 1/k positives to hide and do this several times. You can also use the distribution of scores you get ... Because the scores range from 0 to 1, a change of 10^-4 is bigger than we initially thought. After speeding up the code, we are ... First, I chose to sample half instead of choosing a more reasonable number of positives such as 1/4 or 1/5. I also didnt ...
IMP: Integrative Multi-species Prediction
... lysophosphatidic acid acyltransferase, beta). 0.318. ... hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). ... a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2). 0.011. ... pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2. 0.012. ... a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1. 0.051. ...
Acanthosis Nigricans: Background, Pathophysiology, Etiology
The prevalence in whites is less than 1%. In Latinos, the prevalence in one study was 5.5%, and, in African Americans, the ... 1] Rarely, triazinate, oral contraceptives, fusidic acid, and methyltestosterone have also been associated with acanthosis ... In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and ... At high concentrations, insulin may exert potent proliferative effects via high-affinity binding to IGF-1 receptors. ...
William Marshall, Boulder US - Patent applications
siRNA Targeting Diacylglycerol O-Acyltransferase Homolog 2 (DGAT2) - Efficient sequence specific gene silencing is possible ... siRNA Targeting Diacylglycerol O-Acyltransferase Homolog 2 (DGAT2) - Efficient sequence specific gene silencing is possible ... siRNa targeting neuropilin 1 (NRP1) - Efficient sequence specific gene silencing is possible through the use of siRNA ... siRNA Targeting Fructose-1, 6-bisphosphatase 1 (FBP1) - Efficient sequence specific gene silencing is possible through the use ...
ATP Citrate (pro-S)-Lyase | Profiles RNS
Mammals - Pet Mag
3 monthes ago , Ornithology. Years ago, some well-meaning bird lover passed away and left a pretty decent bundle of money to ... 1 month ago , 10,000 Birds. Apparently, there is a traditional Chinese saying that seeing one pheasant in the wild is better ... 3 monthes ago , 10,000 Birds. Once upon a time, vast forests of Quercus robur , known as common, pedunculate, European or ... 1 month ago , Animal Genetics. Abstract In mammals, imprinted genes are required for both fetal development and postnatal ...
British Journal of Nutrition: Volume 123 - Issue 6 | Cambridge Core
... acyl glycerol phosphate acyltransferase 6 by 15 % (P = 0·02) and diacylglycerol acyltransferase 1 by 27 % (P = 0·02), whereas ... In Expt 1, ileorectostomised rats were given a 3 % IMD diet for 10 d. Separately, a 16-h in vitro digestion of IMD, using ... In Expt 2, upon 24-h fasting, rats were given any of glucose, IMD and high-amylose maize starch (HAMS) (1 g/kg of body weight ... Twenty multiparous sows were randomly assigned to one of the two treatments for 18 d (from day 7 to day 25 of lactation): (1) ...
Enzyme
2-acylglycerol O-acyltransferase. 2-acylglycerol-3-phosphate O-acyltransferase. 2-acylglycerophosphocholine O-acyltransferase. ... Acylglycerol kinase. Acylglycerol lipase. Acylglycerone-phosphate reductase. Acylneuraminate cytidylyltransferase. Acyloxyacyl ... Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. Acyl-lysine deacylase. Acyl-phosphate-hexose ... Alpha,alpha-trehalose-phosphate synthase (GDP-forming). Alpha,alpha-trehalose-phosphate synthase (UDP-forming). Alpha-1,3- ...
Acyl-Carrier Protein S-Malonyltransferase | Colorado PROFILES
SMPDB
acyltransferase. Phosphatidate. phosphatase. Diacylglycerol. O-. acyltransferase. Dihydroxyacetone. phosphate. NADH. H. +. NAD ... Phosphate. Eicosapentaenoyl-. CoA. TG(20:5(5Z,8Z,11Z,14Z,17Z)/20:1(11Z)/20:5(5Z,8Z,11Z,14Z,17Z)). Coenzyme A. Glycolysis. ... TG(20:5(5Z,8Z,11Z,14Z,17Z)/20:1(11Z)/20:5(5Z,8Z,11Z,14Z,17Z)). CoA. Glycolysis. Mitochondria Outer Membrane. Endoplasmic ... phosphate. NADH. Hydrogen Ion. NAD. Glycerol. 3-phosphate. Eicosapentaenoyl-. CoA. Coenzyme A. LPA(20:5(5Z,8Z,11Z,14Z,17Z)/0:0) ...
Human Metabolome Database: HMDB0300054 (DG(i-20:0/20:3(8Z,11Z,14Z)-2OH(5,6)/0:0)) Protein Associations
Diacylglycerol O-acyltransferase 2. Q96PD7 DGAT2. 11q13.5. Enzyme. Not Available. HMDBP04645. 2-acylglycerol O-acyltransferase ... 2-acylglycerol O-acyltransferase 2. Q3SYC2 MOGAT2. 11q13.5. Enzyme. Not Available. HMDBP03160. Patatin-like phospholipase ... Putative diacylglycerol O-acyltransferase 2-like protein 7. Q6IED9 DGAT2L7. 7q22.1. Enzyme. Not Available. ... Diacylglycerol O-acyltransferase 2-like protein 6. Q6ZPD8 DGAT2L6. Enzyme. Not Available. ...
LysophosphatidicEnzymeDiacylglycerolEsterificationGlycerolLysophospholipidKinaseAgpat5BiolBerardinelli-SeipTriacylglycerolCharacterizationMetabolic processELISA KitGeneSource:HGNCPhosphataseAcanthosis2019LiverLipidAtherosclerosisLipodystrophy2002CongenitalActivityTargetsTranscriptionHUMANDrugsEnhancerDifferentiation
Lysophosphatidic3
- Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. (wikipedia.org)
- Abstract The 1-acylglycerol-3-phosphate O-acyltransferases are enzymes that catalyze the conversion of lysophosphatidic acid to phosphatidic acid, which is a precursor of. (petmag.top)
- Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic acid or LPA). (smpdb.ca)
Enzyme12
- In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) is an enzyme that catalyzes the chemical reaction acyl-CoA + 1-acyl-sn-glycerol 3-phosphate ⇌ {\displaystyle \rightleftharpoons } CoA + 1,2-diacyl-sn-glycerol 3-phosphate Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate. (wikipedia.org)
- This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. (wikipedia.org)
- The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. (wikipedia.org)
- This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism. (wikipedia.org)
- The AGPAT2 gene mutations that cause congenital generalized lipodystrophy type 1 greatly reduce or eliminate the activity of the AGPAT2 enzyme. (medlineplus.gov)
- In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. (harvard.edu)
- First, dihydroxyacetone phosphate (or glycerone phosphate) from glycolysis is used by the cytosolic enzyme glycerol-3-phosphate dehydrogenase [NAD(+)] to synthesize sn-glycerol 3-phosphate. (smpdb.ca)
- The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone. (smpdb.ca)
- Last, the enzyme diacylglycerol O-acyltransferase synthesizes triacylglycerol from diacylglycerol and a fatty acyl-CoA. (smpdb.ca)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glucose 6 Phosphate Isomerase (GPI) in serum, plasma and other biological fluids. (kits-elisa.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in saliva and other biological fluids. (lipidx.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Basic Salivary Proline Rich Protein 1 (PRB1) in samples from saliva and other biological fluids with no significant corss-reactivity with analogues from other species. (lipidx.org)
Diacylglycerol8
- The phosphatidate phosphatases (lipins) then dephosphorylate phosphatidate producing 1,2-diacylglycerol, which can then be used to synthesize either phospholipids or TG. (aocs.org)
- Diacylglycerol can also be generated via the monoacylglycerol acyltransferase (MGAT) pathway [5]. (aocs.org)
- In this pathway, 1,2-diacylglycerol is formed by the direct acylation of 2-monoacylglycerol at the sn -1 position. (aocs.org)
- The last step of the TG biosynthetic pathway is catalyzed by acyl coenzyme-A:1,2-diacylglycerol acyltransferase (DGAT) at the endoplasmic reticulum. (aocs.org)
- DGAT catalyzes the synthesis of TGs by forming an ester bond between a fatty acid, donated from a long-chain fatty acyl CoA, and the free hydroxyl group at the sn -3 position of 1,2-diacylglycerol ( Figure 2 ). (aocs.org)
- Diacylglycerol O-Acyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
- This graph shows the total number of publications written about "Diacylglycerol O-Acyltransferase" by people in this website by year, and whether "Diacylglycerol O-Acyltransferase" was a major or minor topic of these publications. (jefferson.edu)
- Below are the most recent publications written about "Diacylglycerol O-Acyltransferase" by people in Profiles. (jefferson.edu)
Esterification2
- 1-Acylglycerol-3-phosphate acyltransferase catalyzes the esterification of the sn -2 carbon of lysophosphatidate forming phosphatidate. (aocs.org)
- Its usual fate is esterification into acylglycerols. (online-sciences.com)
Glycerol9
- Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. (nih.gov)
- TG synthesis occurs via the multistep glycerol-3-phosphate or Kennedy pathway ( Figure 1 ) [3,4]. (aocs.org)
- Glycerol 3-phosphate, derived primarily from glycolysis or gluconeogenesis, is esterified at the sn -1 carbon position by glycerol 3-phosphate acyltransferases producing lysophosphatidate (1-acylglycerol 3-phosphate). (aocs.org)
- Bertrams, M. and Heinz, E. Positional specificity and fatty-acid selectivity of purified sn -glycerol 3-phosphate acyltransferases from chloroplasts. (enzyme-database.org)
- Frentzen, M., Heinz, E., McKeon, T.A. and Stumpf, P.K. Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts. (enzyme-database.org)
- Purification, reconstitution, and characterization of sn -glycerol-3-phosphate acyltransferase. (enzyme-database.org)
- Formation of 1-acylglycerol 3-phosphate from sn -glycerol 3-phosphate and palmityl coenzyme A. (enzyme-database.org)
- Menaya J, Gonzalez-Manchon C, Parrilla R, Ayuso MS: Molecular cloning, sequencing and expression of a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase. (smpdb.ca)
- 1,2-dierucoyl-sn-glycerol_3-phosphate = 1 reactions were found. (tu-bs.de)
Lysophospholipid1
- Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. (medlineplus.gov)
Kinase1
- casein kinase 1 gamma 2 [Source:HGNC Sym. (gsea-msigdb.org)
Agpat51
- Orthologous to human AGPAT5 (1-acylglycerol-3-phosphate O-acyltransferase 5). (nih.gov)
Biol1
- Dev Biol, 2004 Apr 1. (nih.gov)
Berardinelli-Seip2
- At least 26 mutations in the AGPAT2 gene have been identified in people with congenital generalized lipodystrophy (also called Berardinelli-Seip congenital lipodystrophy) type 1. (medlineplus.gov)
- Insulin-resistance syndromes include those with mutations in the insulin receptors (ie, leprechaunism, Rabson-Mendenhall syndrome), peroxisome proliferator-activated receptor gamma (ie, type 1 diabetes with acanthosis nigricans and hypertension), 1-acylglycerol-3-phosphate O-acyl transferase-2 or seipin (Berardinelli-Seip syndrome), lamin A/C (Dunnigan syndrome), and Alstrom syndrome gene. (medscape.com)
Triacylglycerol2
- lyrata (Lyre-leaved rock-cress) F15A23.3 triacylglycerol lipase 1 precursor (EC 3.1.1.3) , arath-LIP2 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. (inrae.fr)
- lyrata (Lyre-leaved rock-cress) Triacylglycerol lipase 2 gene At5g1418 MUA22.18 MUA22.19 MYZUS PERSICAE-INDUCED LIPASE 1 , arath-Q8LPF5 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. (inrae.fr)
Characterization1
- Agarwal AK, Sukumaran S, Cortes VA, Tunison K, Mizrachi D, Sankella S, Gerard RD, Horton JD, Garg A: Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. (smpdb.ca)
Metabolic process1
- Acts upstream of or within acylglycerol metabolic process and hematopoietic progenitor cell differentiation. (nih.gov)
ELISA Kit1
- Description: A sandwich ELISA kit for detection of Basic Salivary Proline Rich Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
Gene1
- siRNA targeting vascular endothelial growth factor receptor 1 (VEGFR1) - Efficient sequence specific gene silencing is possible through the use of siRNA technology. (patentsencyclopedia.com)
Source:HGNC3
- caspase 7 [Source:HGNC Symbol;Acc:HGNC:1. (gsea-msigdb.org)
- akirin 1 [Source:HGNC Symbol;Acc:HGNC:2. (gsea-msigdb.org)
- cyclin C [Source:HGNC Symbol;Acc:HGNC:1. (gsea-msigdb.org)
Phosphatase1
- 2-phosphoxylose phosphatase 1 [Source:H. (gsea-msigdb.org)
Acanthosis2
- Related articles include Type 1 Diabetes Mellitus , Type 2 Diabetes Mellitus , Acanthosis Nigricans , Dermatologic Manifestations of Localized Lipodystrophy , Progressive Lipodystrophy , and Lipodystrophy in HIV . (medscape.com)
- Genetic lipodystrophy is generally related to severe metabolic alterations including insulin resistance (IR) and its associated complications, such as glucose intolerance and diabetes, dyslipidemia, hepatic steatosis, polycystic ovaries, acanthosis nigricans and early cardiovascular (CV) complications [ 1 , 2 ]. (intechopen.com)
20191
- 2019) that is late-born in the NB2-1 Notch ON primary hemilineage (Mark et al. (virtualflybrain.org)
Liver1
- Yamashita, S. and Numa, N. Partial purification and properties of glycerophosphate acyltransferase from rat liver. (enzyme-database.org)
Lipid1
- Nevertheless, all tested Mucoromycotina share features including the ability to produce 18:3 gamma-linoleic acid, use TAG as the storage lipid and have fucose as a cell wall component. (frontiersin.org)
Atherosclerosis1
- Recombinant human lecithin-cholesterol acyltransferase in patients with atherosclerosis: phase 2a primary results and phase 2b design. (harvard.edu)
Lipodystrophy1
- The resulting lack of body fat underlies the varied signs and symptoms of congenital generalized lipodystrophy type 1. (medlineplus.gov)
20021
- 2002 May;31(1):21-3. (medlineplus.gov)
Congenital1
- In 1959, Seip described a similar congenital syndrome, but without diabetes mellitus, in 3 young Norwegian children. (medscape.com)
Activity1
- Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. (nih.gov)
Targets1
- Two overexpression targets ( ACL1 and ACC1 , improving cytosolic acetyl-CoA and malonyl-CoA production, respectively) and two deletion targets (the acyltransferases DGA1 and LRO1 ) resulted in significant (1.8 to 4.4-fold) increases to the fatty alcohol titer in culture tubes. (biomedcentral.com)
Transcription1
- activator of basal transcription 1 [Sour. (gsea-msigdb.org)
HUMAN1
- Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment-Elevation Myocardial Infarction: Results of REAL-TIMI 63B. (harvard.edu)
Drugs1
- Some first-generation antiretroviral drugs used in HIV patients are strongly related with peripheral lipoatrophy and metabolic alterations [ 1 ]. (intechopen.com)
Enhancer1
- migration and invasion enhancer 1 [Sourc. (gsea-msigdb.org)
Differentiation3
- A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. (medlineplus.gov)
- In addition, free IGF-1 levels may be elevated in obese patients with hyperinsulinemia, leading to accelerated cell growth and differentiation. (medscape.com)
- Adipocytes were incubated with various doses of CrAc: 0 (differentiation media only, control), 0.1, 1, and 10 μM. (animbiosci.org)