Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.
A plant species of the family APIACEAE. The stalks are a food source.
Alkaloids extracted from various species of Cinchona.
An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier protein) to another molecule of fatty acyl-(acyl carrier protein), giving a beta-ketoacyl-(acyl carrier protein) with the release of carbon dioxide. EC 2.3.1.41.
The form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL.
Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (From Enzyme Nomenclature 1992) EC 2.3.
Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.
A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.
A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS.
The addition of an organic acid radical into a molecule.
A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.
S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2.
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. It has a preference for acyl groups with a carbon chain length between 4 to 16.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Devices that cover the nose and mouth to maintain aseptic conditions or to administer inhaled anesthetics or other gases. (UMDNS, 1999)
Long, pliable, cohesive natural or manufactured filaments of various lengths. They form the structure of some minerals. The medical significance lies in their potential ability to cause various types of PNEUMOCONIOSIS (e.g., ASBESTOSIS) after occupational or environmental exposure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p708)
Tests or bioassays that measure the skin sensitization potential of various chemicals.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
Exclusive legal rights or privileges applied to inventions, plants, etc.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A calcium-activated enzyme that catalyzes the hydrolysis of ATP to yield AMP and orthophosphate. It can also act on ADP and other nucleoside triphosphates and diphosphates. EC 3.6.1.5.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Organic polymeric materials which can be broken down by naturally occurring processes. This includes plastics created from bio-based or petrochemical-based materials.
A biocompatible polymer used as a surgical suture material.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)
A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.
A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)
A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.
A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Enzymes which transfer sulfur atoms to various acceptor molecules. EC 2.8.1.
Proteins found in ribosomes. They are believed to have a catalytic function in reconstituting biologically active ribosomal subunits.
An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.
A ribosomal protein that may play a role in controlling cell growth and proliferation. It is a major substrate of RIBOSOMAL PROTEIN S6 KINASES and plays a role in regulating the translation (TRANSLATION, GENETIC) of RNAs that contain an RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE.
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.
The rate dynamics in chemical or physical systems.
Family 2.A.69 The Auxin Efflux Carrier (AEC) Family 2.A.70 The Malonate:Na+ Symporter (MSS) Family 2.A.71 The Folate-Biopterin ... Family 4.C.2 The Carnitine O-Acyl Transferase (CrAT) Family 4.C.3 The Acyl-CoA Thioesterase (AcoT) Family 4.D.1 The Putative ... Family 2.A.48 The Reduced Folate Carrier (RFC) Family 2.A.49 Chloride Carrier/Channel (ClC) Family 2.A.50 The Glycerol Uptake ( ... pyridine Anion Carrier (BBP-AC) Family 2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family 2.B.26 The Bis(imidazolyl)- ...
Malonate and oxaloacetate Poisons Complex II Competitive inhibitors of succinate dehydrogenase (complex II).[91]. ... Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase". J. Biol. Chem. 258 (2): 1066-76. PMID 6401712. ... Within the inner mitochondrial membrane, the lipid-soluble electron carrier coenzyme Q10 (Q) carries both electrons and protons ... Oxidative phosphorylation (UK /ɒkˈsɪd.ə.tɪv/, US /ˈɑːk.sɪˌdeɪ.tɪv/ [1] or electron transport-linked phosphorylation) is the ...
Enoyl-acyl carrier protein reductase/Enoyl ACP reductase. *7-Dehydrocholesterol reductase. *Biliverdin reductase ... electron carrier activity. • 2 iron, 2 sulfur cluster binding. • 3 iron, 4 sulfur cluster binding. • 4 iron, 4 sulfur cluster ... The penetrance of the gene is often reported as 77% by age 50[12] (i.e. 77% of carriers will have at least one tumour by the ... Malignancy is common, ranging from 38%-83%[12][13] in carriers with disease. In contrast, tumors caused by SDHD mutations are ...
... feeding of angelic acid to yeasts expressing acyl-CoA ligases from plant species led to angelyl-CoA production rates of ... Furthermore, methyl-malonate supplementation and expression of matB CoA ligase from S. coelicolor allowed for methyl-malonyl- ... In joint action, the identified beta-ketoacyl-(acyl-carrier-protein) synthase III (KAS III), the 3-ketoacyl-(acyl-carrier- ... 5a). MatB is an enzyme exhibiting a certain promiscuity, accepting both malonate and methyl-malonate as substrates [23]. ...
... acyl-carrier protein] = malonate decarboxylase holo-[acyl-carrier protein] + diphosphate. For diagram click here. Other name(s ... EC 2.7.7.66 malonate decarboxylase holo-[acyl-carrier protein] synthase. EC 2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol ... Accepted name: malonate decarboxylase holo-[acyl-carrier protein] synthase. Reaction: 2-(5-triphosphoribosyl)-3-dephospho-CoA ... Comments: The δ subunit of malonate decarboxylase serves as an an acyl-carrier protein (ACP) and contains the prosthetic group ...
β-Ketoacyl-(acyl-carrier-protein (ACP)) synthase (FabF) whose Gram-positive bacteria need to biosynthesize cell membranes is ... it was found that platensimycin bind with the active site of FabF with the carboxylic acid group lying in the malonate-binding ... Platensimycin selectively inhibits fatty acid acyl carrier protein synthase II (FabF). Platensin is a balanced dual inhibitor ... fatty acid acyl carrier protein synthase III) [4]. The third compound lucensimycin A was found to inhibit ribosomal protein ...
The dermatologically acceptable carrier can include 25% to 35% by weight of water, at least 35% by weight of a silicone phase ... acyl lactylates, soaps, TEA stearate, DEA oleth-3 phosphate, polyethylene glycol 20 sorbitan monolaurate (polysorbate 20), ... benzylidene malonate polysiloxane, terephthalylidene dicamphor sulfonic acid, disodium phenyl dibenzimidazole tetrasulfonate, ... The carriers also allow for efficient distribution of said extracts to skin once the composition is topically applied to said ...
... acyl lactylates, acyl tartrates, acyl glutamates and acyl aspartates, alkyl oligoglucoside sulfates, protein fatty acid ... 00123] CARRIERS AND HYDROTROPES [00124] Preferred cosmetics carrier materials are solid or liquid at 25°C and 1013 mbar ( ... benzylidene malonate derivatives, polymeric UV absorbers containing one or more organosilicon radicals, cinnamic acid deriva- ... 0018] The carrier material is preferably maltodextrin or a mixture of maltodextrin with a further suitable carrier material as ...
Family 2.A.69 The Auxin Efflux Carrier (AEC) Family 2.A.70 The Malonate:Na+ Symporter (MSS) Family 2.A.71 The Folate-Biopterin ... Family 4.C.2 The Carnitine O-Acyl Transferase (CrAT) Family 4.C.3 The Acyl-CoA Thioesterase (AcoT) Family 4.D.1 The Putative ... Family 2.A.48 The Reduced Folate Carrier (RFC) Family 2.A.49 Chloride Carrier/Channel (ClC) Family 2.A.50 The Glycerol Uptake ( ... pyridine Anion Carrier (BBP-AC) Family 2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family 2.B.26 The Bis(imidazolyl)- ...
... and acetyl-acyl carrier protein (ACP). [0151] Cytoplasmic male sterility (CMS) in plants, characterized by the suppression of ... Although the mitochondria lack acetyl-CoA carboxylase, it contains the enzymatic equipment necessary to transform malonate into ... Example 1 Generation of Viral Vectors and Zinc Finger Nucleases [0255] Plant Material [0256] Rooted plantlets of Petunia ... 44. The methods of claim 1, wherein the plant comprises a Petunia hybrida or a Nicotiana tabacum. 45-48. (canceled) 49. The ...
... to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), ... Pharmaceutically acceptable carriers and additives are chosen such that side effects from the pharmaceutical compound are ... to provide the corresponding O-acyl derivatives respectively, or oxidized to the keto functional group by an oxidizing agent, ... and a malonate diester, such as diethyl malonate, to provide a vinylene malonate diester. The vinylene malonate diester is ...
Drug-carrier complexes and methods of use thereof. US20040205840 *. Mar 22, 2004. Oct 14, 2004. Pioneer Hi-Bred International, ... Exemplary electron-withdrawing groups include nitro, acyl, formyl, sulfonyl, trifluoromethyl, cyano, chloride, and the like. ... These include aliphatic polyesters selected from the group of oxalates, malonates, succinates, glutarates, adipates, pimelates ... Each carrier must be "acceptable" in the sense of being compatible with the other ingredients of the formulation and not ...
Webster LT, Siddiqui UA, Lucas SV, Strong JM, and Mieyal JJ (1976) Identification of separate acyl-CoA:glycine and acyl-CoA:L- ... 1993). The commercial isopropylidene malonate (2,2-dimethyl-4,6-diketo-1,3-dioxane, also called Meldrums acid; Aldrich ... The carrier gas was helium (constant flow: 1.2 ml/min). The injector port temperature was at 220°C, the transfer line at 240°C ... acyl-CoA-l-glutamine N-acyltransferase; (7), UDP-glucuronyl transferase; (8), acyl-CoA hydrolase; (9), S-3-hydroxyacyl-CoA ...
Pharmaceutically acceptable carriers and additives are chosen such that side effects from the pharmaceutical compound are ... to provide the corresponding O-acyl derivatives respectively, or oxidized to the keto functional group by an oxidizing agent, ... and a malonate diester, such as diethyl malonate, to provide a vinylene malonate diester. The vinylene malonate diester is ... 4-isopropylidenepyridoxine-5-halide is reacted with a metal salt of a malonate diester to give the malonate diester derivative ...
Malonate from malonyl-CoA is transferred to the acyl carrier protein (ACP1 and ACP2) of the type II FAS by ACP S- ... Exchange of acyl chains amongst TAG, glycerolipids and the acyl-CoA pool (acyl editing) provides flexibility to channel carbons ... acyl carrier protein; FabH, β-ketoacyl:ACP synthase III; FabB, β-ketoacyl:ACP synthase I; FabF, β-ketoacyl:ACP synthase II; ... but without the involvement of acyl carrier proteins [19]. Thus, multiple contigs with moderate to high sequence coverage that ...
Accepted name: malonate CoA-transferase. Reaction: acetyl-CoA + malonate = acetate + malonyl-CoA. Other names: malonate ... Systematic name: acyl-CoA:acetate CoA-transferase. Comments: Acts on butanoyl-CoA and pentanoyl-CoA.. Links to other databases ... Systematic name: tRNA (N6-dimethylallyladenosine37):sulfur-(sulfur carrier),S-adenosyl-L-methionine C2-methylthiotransferase. ... Systematic name: tRNA (N6-L-threonylcarbamoyladenosine37):sulfur-(sulfur carrier),S-adenosyl-L-methionine C2- ...
The carrier(s) must be "acceptable" in the sense of being compatible with the other ingredients of the formulation and not ... The term "acyl," as used herein, alone or in combination, refers to a carbonyl attached to an alkenyl, alkyl, aryl, cycloalkyl ... malonate, DL-mandelate, mesitylenesulfonate, methanesulfonate, naphthylenesulfonate, nicotinate, 2-naphthalenesulfonate, ... Examples of acyl groups include formyl, alkanoyl and aroyl.. The term "alkenyl," as used herein, alone or in combination, ...
2. Berg, M., Hilbi, H. and Dimroth, P. The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2-(5"- ... acyl-carrier protein] = AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]. Other name(s): acyl-[acyl-carrier-protein ... HS-acyl-carrier protein:acetate ligase; [acyl-carrier protein]:acetate ligase; MadH. Systematic name: acetate:[acyl-carrier- ... Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein ...
The keto synthase (KS) domain and acyl carrier protein (ACP) of the CTB1 likely involved in chain elongation are also indicated ... 1975) suggested that cercosporin is synthesized via the polyketide pathway using acetate and malonate subunits. The first gene ... and two acyl carrier protein (ACP) domains (Choquer et al., 2005) that act cooperatively to form the polyketomethylene backbone ... 1. E. A. S. Buiate, K. V. Xavier, N. Moore, M. F. Torres, M. L. Farman, C. L. Schardl, L. J. Vaillancourt, A comparative ...
pft:JBW_04340 Beta-ketoacyl-acyl-carrier-protein syntha K13614 2510 102 ( -) 29 0.385 52 ,-, 1 pmad:BAY61_19620 lycopene ... cnt:JT31_10385 malonate decarboxylase subunit beta K13932 276 101 ( -) 29 0.318 107 -, 1 dca:Desca_2157 mannose-6-phosphate ... ttf:THTE_0865 3-oxoacyl-[acyl-carrier protein] reductas 275 102 ( -) 29 0.346 81 -, 1 ttl:TtJL18_1883 hypothetical protein 306 ... tup:102493775 acyl-CoA dehydrogenase family member 10 K11729 971 113 ( 1) 32 0.321 134 ,-, 5 ade:Adeh_3005 Alanine ...
Carriers employed may be either solid or liquid. Exemplary solid carriers are lactose, sucrose, talc, gelatin, agar, pectin, ... acyl (--C(═O)R), alkoxy (--OR), amido (--NRC(═O)R or --C(═O)NRR), amino (--NRR), carboxylic acid (--CO2H), carboxylic ... malonate, mandelate, mesylate, metaphosphate, methane-sulfonate, methylsulfate, monohydrogenphosphate, mucate, napsylate, ... or gel-phase carriers or excipients. These carriers and excipients may provide marked improvement in the bioavailability of ...
When the velocity of the carrier stream is higher than the polymer stream, the carrier pulls on the polymer, focusing it into a ... diethyl malonate, diethyl sulfide, diethylene glycol dibutyl ether, diisobutyl ketone, diisopropyl sulfide, dimethyl phthalate ... polymers of ethylene-vinyl acetates and other acyl substituted cellulose acetates, non-degradable polyurethanes, polystyrenes, ... The stream flows into a water bath, where the carrier liquid stays on top of water but the microcapsules escape the carrier ...
Acyl group acceptor, carnitine palmitoyltransferase II, an enzyme that participates in fatty acid β-oxidation it... Dec ; 89 ( ... 680 Whole gene analysis € 240 Carrier analysis € 240 extra for Prenatal analysis. Carnitine palmitoyltransferase 2 (CPT2) ... Site binds to malonyl-CoA via the dicarbonyl group of the malonate moiety of malonyl-CoA to either the site... ( 5-6 ):521-32. ... Isolated in 2002 a translocase then shuttles the acyl carnitine across the inner mitochondrial membrane and is the rate- ...
b) alkoxy and acyl substituted aromatic compounds such as 2,2-dimethyloxy-2-phenyl, 1,3,5-triacetyl benzene, 2,5-diethoxy ... it is believed that the bromination reaction proceeds by means of a rapid radical chain reaction with the chain carrier being, ... malonates, etc. ... Wherein R1, R2 and R3 are each independently selected from the ... Jun 1, 1999. Nohr; Ronald Sinclair. Ink for ink jet printers. US5942555 *. Mar 21, 1996. Aug 24, 1999. Surmodics, Inc.. ...
An acyl radical is preferably formyl or acyl selected from the group consisting of CO-R", CS-R, CO-OR, CS-OR, CS-SR, SOR ... carriers, colorants, antifoams, adjuvants such as mineral or vegetable oils and derivatives thereof, evaporation inhibitors and ... preferably compounds such as diethyl 5-chloro-8-quinolinoxy-malonate, dally 5-chloro-8-quinolJnoxymalonate, methyl ethyl 5- ... b) R1 is CO-N-(C1-C4-alkyl)2 and R1 is NHR1 where R1 is an acyl radical, preferably formyl, or. c) R1 is C2-C4-alkoxy and R1 is ...
This compound was prepared in a manner analogous to that described in Preparation 13, but using the appropriate acyl ester. ... For example, the compounds can be formulated with common excipients, diluents, or carriers, and formed into tablets, capsules, ... malonate, mandelate, mesylate, nicotinate, isonicotinate, nitrate, oxalate, phthalate, teraphthalate, phosphate, ... Examples of excipients, diluents, and carriers that are suitable for such formulations include the following: fillers and ...
Suitable carriers for the preparation of solutions, for example of solutions for injection, or of emulsions or syrups are, for ... Diethyl 2-(dicyanomethylene)malonate (prepared analogous to Sentman et. al. J. Org. Chem. 1982, 47, 4577) (1 g, 4.5 mmol) was ... Acylation of the primary amino group of the acyl hydrazide with an appropriate acylation reagent bearing the desired R.sup.5 ... Suitable carriers for microcapsules, implants or rods are, for example, copolymers of glycolic acid and lactic acid. Besides ...
... peptide carrier protein; KS, ketoacyl synthase; AT, acyl transferase; DH, dehydratase; KR, ketoreductase; AC, acyl carrier ... We note that malonate will also be labeled by H13CO3- as it is derived from acetate by carboxylation. However, the label will ... extend a starter molecule by condensation/decarboxylation of malonate extender units (for reviews see e.g. [11, 12]). The ... is envisioned to be bound to the peptide carrier protein domain by a thioester bond, is released upon ureido bond formation. It ...
The term "acyl" when used without the "substituted" modifier refers to the group -C(0)R, in which R is a hydrogen, alkyl, aryl ... The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (such as, glycerol, propylene ... malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-P-hydroxynaphthoate, gentisates, ... The term "amido" (acylamino), when used without the "substituted" modifier, refers to the group -NHR, in which R is acyl, as ...
... tuberculosis Enoyl Acyl Carrier Protein Reductase enzyme (InhA): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R. ... Scheme 2 as illustrated in Method-2 can be used for the synthesis of 2-substituted aryl malonates from diethyl malonate ... The following 2-aryl malonates were prepared according to the Method-2 using corresponding commercially available malonates and ... tuberculosis Enoyl Acyl Carrier Protein Reductase enzyme (InhA). In yet another aspect of the present invention, a method is ...
C8-C20 acyl isethionates, C8-C20 alkyl ether phosphates, C8-C20 sarcosinates, C8-C20 acyl lactylates, sulfoacetates and ... Cosmetic compositions with ammonium malonates US20040185074A1 (en) 2004-09-23. Odor control in amine salt containing cosmetic ... Fatty acids having from 10 to 30 carbon atoms may also be suitable as cosmetically acceptable carriers. Illustrative of this ... Sunscreen cosmetic compositions storage stabilized with malonate salts US20040202689A1 (en) 2004-10-14. Terpenoid fragrance ...
Examples of suitable carriers, solvents, diluents and delivery vehicles include water, ethanol, polyalcohol, and mixtures ... in which Rkacan be acyl or aroyl, and a value of Rk+1adefined above, or a "cyclic system substituents" are RkaRk+1aNC(=O)- or R ... malonate, salicylates, propionate, econsultancy, bansilalpet, sulfamate and the like (for a Detailed description of the ... RkaRk+1the aN-, RkaN=, RkaRk+1aN-alkyl-, RkaRk+1aNC(=O)- or RkaRk+1aNSO2-, where Rkaand Rk+1arepresent independently from each ...
A solid carrier can be one or more substances, which may also act as diluents, flavoring agents, binders, preservatives, tablet ... and acyl (e.g.. -C(0)CH3, -C(0)CF3, -C(0)CH2OCH3; and the like).. [0036] Similar to the substituent moieties described for the ... C was added diethyl malonate (20.0g; 0.125mmol) dropwise. The contents were warmed to ambient temperature and 3-chlorobenzyl ... 0127] In powders, the carrier is a finely divided solid, which is in a mixture with the finely divided active component. In ...
  • A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of mycolic acid biosynthesis through inhibition of M. tuberculosis Enoyl Acyl Carrier Protein Reductase enzyme (InhA): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sup.5 are as defined herein. (patents.com)
  • 1 . A conjugate comprising an enzyme and a biodegradable polymer, wherein the enzymatic activity of the enzyme is higher relative to that of the enzyme in the absence of the biodegradable polymer. (google.com)
  • 2 . The conjugate of claim 1 , wherein the enzymatic activity of the enzyme is at least 10 fold higher relative to that of the enzyme in the absence of the biodegradable polymer. (google.com)
  • 11 . The conjugate of claim 1 , wherein the enzyme is conjugated to the polymer through a covalent bond. (google.com)
  • 12 . The conjugate of claim 1 , comprising a tether between the enzyme and the biodegradable polymer. (google.com)
  • 15 . The conjugate of claim 1 , wherein the enzyme is a multimeric enzyme. (google.com)
  • 17 . The conjugate of claim 1 , wherein the enzyme is an extracellular enzyme. (google.com)
  • 18 . The conjugate of claim 1 , wherein the enzyme is an apyrase. (google.com)
  • The inhibition induces apoptosis, as the inactive enzyme fails to degrade ΙκΒ and activate NFKB, stabilizes pro-apoptotic proteins, and leaves the cell overloaded with non- degraded polypeptides (Crawford, et ah, 201 1). (lens.org)
  • New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1 H -1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives, J . Enzyme Inhib . (edu.pl)
  • A similar rate of hydrolysis of isomaltose by both isozymes was found indicating that the reduced catalytic activity of the variant isozyme toward glycogen is not the result of a reduced ability of this enzyme to cleave the alpha-1,6 linkages of glycogen. (worldwidescience.org)
  • 1. Stadtman, E.R. Acyl-coenzyme A synthesis by phosphotransacetylase and coenzyme A transphorase. (qmul.ac.uk)
  • 1. Hersh, L.B. and Jencks, W.P. Coenzyme A transferase. (qmul.ac.uk)
  • 2. Massaro, E.J. and Lennarz, W.J. The partial purification and characterization of a bacterial fatty acyl coenzyme A synthetase. (qmul.ac.uk)
  • Long-chain fatty acids in all tissues and medium-chain fatty acids in most tissues (an important exception is the liver) are esterified to coenzyme A in the cytosol and cannot enter the mitochondrial matrix to undergo beta oxidation without the action of carnitine and 3 proteins (carnitine palmitoyltransferase 1, carnitine acylcarnitine translocase, and carnitine palmitoyltransferase 2). (colegiomontpellier.net)
  • As the cell's primary hydrogen carrier, NAD + functions as a coenzyme that is essential for the progress of many biochemical reactions. (ijmbs.org)
  • β -Ketoacyl-(acyl-carrier-protein (ACP)) synthase (FabF) whose Gram-positive bacteria need to biosynthesize cell membranes is the target of inhibition of platensimycin. (hindawi.com)
  • Platensimycin selectively inhibits fatty acid acyl carrier protein synthase II (FabF). (hindawi.com)
  • Platensin is a balanced dual inhibitor of both FabF and FabH (fatty acid acyl carrier protein synthase III) [ 4 ]. (hindawi.com)
  • The individual FAS component enzymes are ac(et)yltransferase (AC), malonyl/acetyl- or malonyl/palmitoyl-transacylase (AT, MPT), ketoacyl synthase (KS) ketoacyl reductase (KR), dehydratase (DH), enoyl reductase (ER), acyl carrier protein (ACP), and thioesterase (TE). (asm.org)
  • and each of R a , R b , and R c is, independently, H, substituted or unsubstituted C 1-4 alkyl, substituted or unsubstituted C 1-4 cycloalkyl, or cyano. (justia.com)
  • A furfural derivative having the chemical formula (1) ##STR00001## where R represents hydrogen, an alkyl group or an acyl group, is prepared in a process, which. (patents.com)
  • Commencing with simple alkyl aldehydes, we are now about to effect the synthesis of substituted 1,3-butadienes in a single step with high yields and diastereoselectivities. (ubc.ca)
  • Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for FGFR 1-3. (justia.com)
  • In vivo evaluation of the CB 1 allosteric modulator LDK1258 reveals CB 1 -receptor independent behavioral effects, Pharmacol . (edu.pl)
  • Furthermore, methyl-malonate supplementation and expression of matB CoA ligase from S. coelicolor allowed for methyl-malonyl-CoA synthesis and supported, together with parts of the ssf pathway, angelyl-CoA titres of approximately 1.5 mg/L. Finally, feeding of angelic acid to yeasts expressing acyl-CoA ligases from plant species led to angelyl-CoA production rates of approximately 40 mg/L. (biomedcentral.com)
  • N-alkoxyphthalimides, when subjected to radical conditions, are able to generate oxygen radicals, which may undergo a 1,5-hydrogen atom transfer, and subsequently cyclize onto a nearby radical acceptor. (ubc.ca)
  • A 1 receptor inhibits adenylate cyclase and activates or inhibits (depending on cell type) phosphoinositide metabolism. (russianpatents.com)
  • Because of its multifaceted physiological role, which includes regulation of apoptosis, inhibition of proteasome became an attractive intervention to stop cancer (Crawford, et ah, 201 1). (lens.org)
  • This suggests that selective inhibition of FGFR-4 without inhibition of other isoforms of FGFR, including FGFR-1, may be desirable in order to avoid certain toxicities. (justia.com)
  • 7. The compound of claim 1 in combination with a pharmaceutically acceptable excipient. (freepatentsonline.com)
  • 7. A pharmaceutical composition comprising a compound according to any of claim 1, 5, or 6, and a pharmaceutically acceptable carrier of diluent. (patentsencyclopedia.com)
  • 8. A pharmaceutical composition comprising a compound according to any of claim 1, 5, or 6, at least one additional HIV-inhibiting agent, and a pharmaceutically acceptable carrier of diluent. (patentsencyclopedia.com)
  • 1. Fankhauser, H., Schiff, J.A. and Garber, L.J. Purification and properties of adenylyl sulphate:ammonia adenylyltransferase from Chlorella catalysing the formation of adenosine 5′ -phosphoramidate from adenosine 5′ -phosphosulphate and ammonia. (qmul.ac.uk)
  • The primary metabolites, in contrast, such as phytosterols, acyl lipids, nucleotides, amino acids, and organic acids, are found in all plants and perform metabolic roles that are essential and usually evident. (jpbsonline.org)
  • R - and S -3-hydroxy-4-phenylbutyrate (PHB), phenylacetone, and 1-phenyl-2-propanol, as well as PA and PB glucuronides. (aspetjournals.org)
  • 8. The compound of claim 1 selected from the group consisting of trans-3-benzyloxy-cis-4-hydroxy-L-proline, (2S,3S,4S)-3-phenoxy-4-hydroxy-proline, cis-4-hydroxy-trans-3-methoxy-L-proline, and cis-4-hydroxy-trans-3-isopropoxy-L-proline. (freepatentsonline.com)
  • 1. A method of inhibiting post-menopausal bone loss in a post-menopausal woman in need of treatment to prevent or treat post-menopausal osteoporosis comprising administering a single daily oral dose to said woman of an effective amount of 6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl-4-[2-(piperidin-1-yl)ethoxyphenyl]methanone hydrochloride. (google.es)
  • The present invention provides a method for increasing the molar ratio of tetrahydrofuran to 1,4-butanediol in a process for the production of 1,4-butanediol. (patents.com)
  • Other modules binding to the a face include 1 I S and PA200 activators and PI31 "proteasome inhibitor. (lens.org)
  • Ectopic mineralization, characterized by inappropriate calcium-phosphorus deposition in soft tissue, has been observed in rats treated with an FGFR-1 inhibitor (Brown, A P et al. (justia.com)
  • 14 . The conjugate of claim 1 , further comprising a targeting agent. (google.com)
  • 9. A method of treating or preventing hepatitis C infection in a mammal, said method comprising administering to said mammal a compound according to any of claim 1, 5, or 6 in an amount effective for the treatment or prevention of said hepatitis C infection. (patentsencyclopedia.com)
  • 12. A method of inhibiting HIV replication in a mammal, said method comprising administering to said mammal a compound according to any of claim 1, 5, or 6 in an amount effective to inhibit HIV replication in a mammal. (patentsencyclopedia.com)
  • Cercosporin is a perylenequinone that absorbs light and reacts with oxygen molecules to generate reactive oxygen species, including singlet oxygen ( 1 O 2 ) and superoxide radicals (O 2 - ) ( Daub and Hangarter, 1983 ). (wiley.com)
  • Flame retardant polyphosphate esters: 1. (iisc.ac.in)
  • PubMed:14711372 ] Mitochondrial carnitine palmitoyltransferase‐1 (CPT1) is a target for oxidative inactivation in human cells. (colegiomontpellier.net)
  • [1] , [2] An adequate intracellular level of NAD + is particularly critical for optimal mitochondrial function. (ijmbs.org)
  • Molecular biological studies have established that AMPA receptors are composed of subunits (GluR 1 -GluR 4 ), which can assemble to form functional ion channels. (justia.com)
  • Stable personal care composition comprising hydrophobic modified silica, a particulate material and a dermatologically-acceptable carrier, said carrier comprising about 70% or greater, by weight of the carrier, of at least one water-soluble polyol, said water-soluble polyol having a solubility parameter. (google.es)
  • Carnitine Palmitoyltransferase 1A Deficiency Bennett MJ - 2016 PMID: 20301700: Organization of the human liver carnitine palmitoyltransferase 1 gene ( CPT1A) and identification of novel mutations in hypoketotic hypoglycaemia. (colegiomontpellier.net)
  • 680 Whole gene analysis € 240 Carrier analysis € 240 extra for Prenatal analysis. (colegiomontpellier.net)
  • The penetrance of the gene is often reported as 77% by age 50 [12] (i.e. 77% of carriers will have at least one tumour by the age of 50). (wikipedia.org)
  • Currently (2011), families with silent SDHB mutations are being screened [14] to determine the frequency of silent carriers. (wikipedia.org)
  • And 2A receptors are one of the 4 subtypes (A 1 , A 2A , A 2B and a 3 ) adenosine receptors. (russianpatents.com)
  • In addition, stimulation of A 1 receptors causes activation of potassium and decontamination of calcium channels [Iredale P.A., Alexander, S.P.H., Hill S.J. Br. (russianpatents.com)
  • SUBSTANCE: present invention refers to new substituted phenoxyacetic acids of general formula 1 possessing the properties of a selective antagonist inhibiting A 2a adenosine receptor activity. (russianpatents.com)
  • Nos recherches ont mis en évidence que plusieurs paramètres physiques et chimiques, tels que l'émulsification d'une huile linolénique avec de la lécithine de soja, la position de l'ALA sur le squelette glycérique du triglycéride alimentaire mais aussi la composition de la matrice permettraient de moduler la biodisponibilité et le devenir métabolique de l'ALA dans l'organisme. (worldwidescience.org)
  • 1. Chou, T.C. and Lipmann, F. Separation of acetyl transfer enzymes in pigeon liver extract. (qmul.ac.uk)
  • FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. (justia.com)
  • EFFECT: preparing new substituted phenoxyacetic acids of general formula 1 possessing the properties of the selective agonist inhibiting A 2a adenosine receptor activity. (russianpatents.com)
  • B Vitamins May Cut Heart Disease Risk", Harvard Health Letter, 1 page (1998). (patentgenius.com)