SNARE Proteins: A superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. They share a homologous SNARE motif. The SNARE proteins are divided into subfamilies: QA-SNARES; QB-SNARES; QC-SNARES; and R-SNARES. The formation of a SNARE complex (composed of one each of the four different types SNARE domains (Qa, Qb, Qc, and R)) mediates MEMBRANE FUSION. Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e., SNAPs (no relation to SNAP 25.)Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Synaptic Vesicles: Membrane-bound compartments which contain transmitter molecules. Synaptic vesicles are concentrated at presynaptic terminals. They actively sequester transmitter molecules from the cytoplasm. In at least some synapses, transmitter release occurs by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents.Vesicular Transport Proteins: A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. They play a role in the intracellular transport of molecules contained within membrane vesicles. Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported.Qa-SNARE Proteins: A subfamily of Q-SNARE PROTEINS which occupy the same position as syntaxin 1A in the SNARE complex and which also are most similar to syntaxin 1A in their AMINO ACID SEQUENCE. This subfamily is also known as the syntaxins, although a few so called syntaxins are Qc-SNARES.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.R-SNARE Proteins: SNARE proteins where the central amino acid residue of the SNARE motif is an ARGININE. They are classified separately from the Q-SNARE PROTEINS where the central amino acid residue of the SNARE motif is a GLUTAMINE. This subfamily contains the vesicle associated membrane proteins (VAMPs) based on similarity to the prototype for the R-SNAREs, VAMP2 (synaptobrevin 2).Exocytosis: Cellular release of material within membrane-limited vesicles by fusion of the vesicles with the CELL MEMBRANE.Ecological Systems, Closed: Systems that provide for the maintenance of life in an isolated living chamber through reutilization of the material available, in particular, by means of a cycle wherein exhaled carbon dioxide, urine, and other waste matter are converted chemically or by photosynthesis into oxygen, water, and food. (NASA Thesaurus, 1988)Synaptosomal-Associated Protein 25: A ubiquitous target SNARE protein that interacts with SYNTAXIN and SYNAPTOBREVIN. It is a core component of the machinery for intracellular MEMBRANE FUSION. The sequence contains 2 SNARE domains, one is the prototype for the Qb-SNARES, and the other is the prototype for the Qc-SNARES.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Lipid Bilayers: Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.Information Services: Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Software: Sequential operating programs and data which instruct the functioning of a digital computer.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Hydroxymethylglutaryl-CoA Reductase Inhibitors: Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.Heptanoic Acids: 7-carbon saturated monocarboxylic acids.Lipoproteins, HDL: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.Pyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Plaque, Atherosclerotic: Lesions formed within the walls of ARTERIES.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Thrombomodulin: A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Osteotomy, Sagittal Split Ramus: Sagittal sectioning and repositioning of the ramus of the MANDIBLE to correct a mandibular retrusion, MALOCCLUSION, ANGLE CLASS III; and PROGNATHISM. The oblique sectioning line consists of multiple cuts horizontal and vertical to the mandibular ramus.Dentistry, Operative: That phase of clinical dentistry concerned with the restoration of parts of existing teeth that are defective through disease, trauma, or abnormal development, to the state of normal function, health, and esthetics, including preventive, diagnostic, biological, mechanical, and therapeutic techniques, as well as material and instrument science and application. (Jablonski's Dictionary of Dentistry, 2d ed, p237)Cryoelectron Microscopy: Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Dental Models: Presentation devices used for patient education and technique training in dentistry.Eye, Artificial: A ready-made or custom-made prosthesis of glass or plastic shaped and colored to resemble the anterior portion of a normal eye and used for cosmetic reasons. It is attached to the anterior portion of an orbital implant (ORBITAL IMPLANTS) which is placed in the socket of an enucleated or eviscerated eye. (From Dorland, 28th ed)1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.Pseudophakia: Presence of an intraocular lens after cataract extraction.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).HydrocarbonsCell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Molecular Dynamics Simulation: A computer simulation developed to study the motion of molecules over a period of time.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Animals, LaboratoryProtein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Minority Groups: A subgroup having special characteristics within a larger group, often bound together by special ties which distinguish it from the larger group.Immunological Synapses: The interfaces between T-CELLS and ANTIGEN-PRESENTING CELLS. Supramolecular organization of proteins takes place at these synapses involving various types of immune cells. Immunological synapses can have several functions including LYMPHOCYTE ACTIVATION; enhancing, balancing, or terminating signaling; or directing cytokine secretion.Membrane Microdomains: Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins.Synapses: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Glycosphingolipids: Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)Pyridinium CompoundsThermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Aspergillus: A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.Phospholipase D: An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.Aspergillus nidulans: A species of imperfect fungi from which the antibiotic nidulin is obtained. Its teleomorph is Emericella nidulans.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Phospholipases A2: Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.Phospholipases A: Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.Aspergillus niger: An imperfect fungus causing smut or black mold of several fruits, vegetables, etc.Phospholipases: A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-.Aspergillus fumigatus: A species of imperfect fungi from which the antibiotic fumigatin is obtained. Its spores may cause respiratory infection in birds and mammals.
*  Lucinactant
... contains the peptide sinapultide (KL4 acetate), dipalmitoylphosphatidylcholine (DPPC), 1-palmitoyl-2-oleoyl-sn- ... 1] Archived April 20, 2009, at the Wayback Machine. "FDA approves Surfaxin to prevent breathing disorder in premature infants ...
*  List of MeSH codes (D10)
25-hydroxyvitamin d 2 MeSH D10.570.938.590 --- lanosterol MeSH D10.627.430.354 --- cod liver oil MeSH D10.627.430.450 --- fatty ... 1-butanol MeSH D10.289.110.220 --- chlorobutanol MeSH D10.289.110.855 --- tert-butyl alcohol MeSH D10.289.220.720 --- sodium ... 1,2-dipalmitoylphosphatidylcholine MeSH D10.570.755.375.760.400.840 --- phosphatidylethanolamines MeSH D10.570.755.375.760.400. ... dodecyl sulfate MeSH D10.289.230.250 --- dolichol phosphates MeSH D10.289.600.610 --- 1-octanol MeSH D10.351.801.632 --- ...
*  Stable nucleic acid lipid particle
The SNALPs (around 81 nm in size here) were formulated by spontaneous vesiculation from a mixture of cholesterol, dipalmitoyl phosphatidylcholine ... Further, only 2 of the 6 mice treated had noticeable tumors around the implantation site. Even so, GAPDH, a tumor-derived ... Researchers tested a 1 mg/kg single dose, too, obtaining a 68% silencing of the target gene, indicating dose-dependent ... According to the study, a 2 mg/kg dose of PLK1-specific siRNA administered for 3 weeks to mice implanted with tumors resulted ...
*  Tecemotide
... and dipalmitoyl phosphatidylcholine (DPPC) Function: Structure of the liposome Enhances uptake by APCs The antigen tecemotide ... The first 25 amino acids of tecemotide are derived from the mucin 1 (MUC1) sequence: human mucin-1 (carcinoma-associated mucin ... doi:10.1007/s00432-011-1003-3 Merck KGaA to test Stimuvax in breast cancer trial (FierceVaccines) UPDATE 2-Merck to test ... doi:10.1016/S1470-2045(13)70510-2 Merck Discontinues Clinical Development Program of Tecemotide as a Monotherapy in Stage III ...
*  Model lipid bilayer
Hollars, C W; Dunn, R C (1998). "Submicron Structure in l--Dipalmitoylphosphatidylcholine Monolayers and Bilayers Probed with ... doi:10.1007/978-1-62703-782-2_7. ISBN 978-1-62703-781-5. PMID 24395412. Roos, C; Kai, L; Proverbio, D; Ghoshdastider, U; ... 75 (1): 342-353. Bibcode:1998BpJ....75..342H. doi:10.1016/s0006-3495(98)77518-6. PMC 1299703 . PMID 9649391. J T Groves, N ... The size and nature of this gap depends on the substrate material and lipid species but is generally about 1 nm for ...
*  Pulmonary surfactant
40% dipalmitoylphosphatidylcholine (DPPC); ~40% other phospholipids (PC); ~10% surfactant proteins (SP-A, SP-B, SP-C and SP-D ... Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid with two 16-carbon saturated chains and a phosphate group with ... Up to 90% of surfactant DPPC (dipalmitoyl phosphatidylcholine) is recycled from the alveolar space back into the type II ... dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. As a medication, pulmonary surfactant is on the WHO Model List ...
*  Phosphatidylcholine
Dipalmitoyl phosphatidylcholine (a.k.a. lecithin) is a major component of pulmonary surfactant and is often used in the L/S ... Animal lung phosphatidylcholine, for example, contains a high proportion of Dipalmitoylphosphatidylcholine. Phospholipase D ... 86 (2): 163-171. doi:10.1079/BJN2001391. Chung, Shu-Ying; Moriyama, Tomoe; Uezu, Eiko; Uezu, Kayoko; Hirata, Rieko; Yohena, ... 4 (2): 135. doi:10.4103/0974-2077.85040. ISSN 0974-2077. Treacy, PJ; Goldberg, DJ (2006). "Use of phosphatidylcholine for the ...
PLA2G10 phospholipase A2 group X [Homo sapiens (human)] - Gene - NCBI  PLA2G10 phospholipase A2 group X [Homo sapiens (human)] - Gene - NCBI
Conserved Domains (1) summary. cd00125. Location:43 → 157. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 119. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 122. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 118. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ...
more infohttps://www.ncbi.nlm.nih.gov/gene/8399
Prdx6 peroxiredoxin 6 [Rattus norvegicus (Norway rat)] - Gene - NCBI  Prdx6 peroxiredoxin 6 [Rattus norvegicus (Norway rat)] - Gene - NCBI
antioxidant protein 2. non-selenium glutathione peroxidase. thiol-specific antioxidant protein. NP_446028.1. *EC 1.11.1.15 ... Conserved Domains (2) summary. COG0450. Location:5 → 200. AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [ ... 1-Cys PRX. 1-Cys peroxiredoxin. NSGPx. acidic calcium-independent phospholipase A2. aiPLA2. ... The MAPKs can mediate phosphorylation of Prdx6 at Thr-177 with a consequent marked increase in its aiPLA(2) activity. Title: ...
more infohttps://www.ncbi.nlm.nih.gov/gene/94167
Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells.  Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells.
1-Methyl-3-isobutylxanthine / pharmacology. 8-Bromo Cyclic Adenosine Monophosphate / metabolism. Cell Differentiation. Cells, ... 9613677 - Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cel.... ... 1). Mixtures of these PC molecular species, phosphatidylglycerol, and SP-B and SP-C were functionally active and rapidly ...
more infohttp://www.biomedsearch.com/nih/Lipidomics-cellular-secreted-phospholipids-from/16513897.html
Pla2g6 - 85/88 kDa calcium-independent phospholipase A2 - Rattus norvegicus (Rat) - Pla2g6 gene & protein  Pla2g6 - 85/88 kDa calcium-independent phospholipase A2 - Rattus norvegicus (Rat) - Pla2g6 gene & protein
SSF52151 SSF52151, 1 hit. PROSITEi. View protein in PROSITE. PS50297 ANK_REP_REGION, 1 hit. PS50088 ANK_REPEAT, 4 hits. ... 1.25.40.20, 2 hits. InterProi. View protein in InterPro. IPR016035 Acyl_Trfase/lysoPLipase. IPR002110 Ankyrin_rpt. IPR020683 ... 1. Keywords - PTMi. Phosphoprotein. Proteomic databases. PaxDb, a database of protein abundance averages across all three ... LITRK…LNNLE → Q in isoform Short. 1 Publication. ,p>Manually curated information that is based on statements in scientific ...
more infohttps://www.uniprot.org/uniprot/P97570
PLB1 - Phospholipase B1, membrane-associated precursor - Cavia porcellus (Guinea pig) - PLB1 gene & protein  PLB1 - Phospholipase B1, membrane-associated precursor - Cavia porcellus (Guinea pig) - PLB1 gene & protein
Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional ... 1 - 20. Sequence analysisAdd BLAST. 20. ,p>This subsection of the 'PTM / Processing' section describes the extent of a ... 1Add BLAST. 309. ,p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence ... 2Add BLAST. 346. ,p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence ...
more infohttp://www.uniprot.org/uniprot/O70320
Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked...  Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked...
n = 18 (WT), 10 (D186/D193A), 11 (D51/E52/E55A), 13 (D166/E170A)] and dataset 2 [1 mm Ca2+, 1.2 mm Ca2+, 2 mm Ca2+, 3 mm Ca2+. ... 1D, 8D) and, indeed, the unclamping effect in the cell correlated with a lack of Cpx clamping in vitro (Figs. 1G, 8F). This ... 5A,B; 1 mm). Increasing the [Ca2+] up to 8 mm increased the EPSC amplitude in all mutants (Fig. 5A,B; 8 mm). Remarkably, for ... 7C,D). No rescue of the evoked EPSC amplitude was found after syt-1 OE for any of the mutations (cf. Figs. 7E,F, 3A,B). The ...
more infohttp://www.jneurosci.org/content/36/47/11865
23034757[pmid]  - BioMedLib™ search engine  23034757[pmid] - BioMedLib™ search engine
1. Martinez-Seara H, Róg T: Molecular dynamics simulations of lipid bilayers: simple recipe of how to do it. Methods Mol Biol; ... 1 23034757[pmid] 1 results Searchbox Export PDF RSS Email Delete Email this search result to the following email address: [X] ... 2 years. 3 years. 5 years. 10 years. Or published in the following date range: From (yyyy/mm/dd - month and day are optional) ... Prev First 1 Last Next , products , help , privacy and use , advertising programs , subscribe , NLM-notes , contact us , wipimd ...
more infohttp://bmlsearch.com/?kwr=23034757%5Bpmid%5D&cmpgp0613UwUb=ICD30613TWEitjuoz4&dt02=&dt03=&xpclps3=Matches
Impact of Short-Term Administration of High-Density Lipoproteins and Atorvastatin on Atherosclerosis in Rabbits |...  Impact of Short-Term Administration of High-Density Lipoproteins and Atorvastatin on Atherosclerosis in Rabbits |...
Rabbits received 2 infusions of HDL each containing 25 mg apoA-I (or apoA-II). A 3-kg rabbit with a plasma volume of &120 mL ... Figure 1. Effect of administration of atorvastatin, native and reconstituted HDL on lesion area (mm2) in a rabbit model of ... Infusion of rHDL containing apoA-I:PLPC reduced lesion area by 35% (1.39±0.15 versus 2.13±0.15 mm2 in rHDL-treated and ... Discoidal rHDL containing: (1) apoA-I complexed to 1-palmitoyl-2-linoleoyl phosphatidylcholine (PLPC); (2) apoA-I complexed to ...
more infohttp://atvb.ahajournals.org/content/25/11/2416
Thermochemotherapy: Synergism between hyperthermia and liposomal bleomycin in mice bearing melanoma B16F1<...  Thermochemotherapy: Synergism between hyperthermia and liposomal bleomycin in mice bearing melanoma B16F1<...
Large unilammelar vesicles (LUV) made of synthetic lipids (disteroyl phosphatidylcholine and dipalmitoyl phosphatidylcholine) ... Large unilammelar vesicles (LUV) made of synthetic lipids (disteroyl phosphatidylcholine and dipalmitoyl phosphatidylcholine) ... Large unilammelar vesicles (LUV) made of synthetic lipids (disteroyl phosphatidylcholine and dipalmitoyl phosphatidylcholine) ... Large unilammelar vesicles (LUV) made of synthetic lipids (disteroyl phosphatidylcholine and dipalmitoyl phosphatidylcholine) ...
more infohttps://manipal.pure.elsevier.com/en/publications/thermochemotherapy-synergism-between-hyperthermia-and-liposomal-b-2
Schematic Representation of the Simulation System Const | Open-i  Schematic Representation of the Simulation System Const | Open-i
Mentions: The nAChR was embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer [18,27], the nAChR/DPPC complex was ... Mentions: The nAChR was embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer [18,27], the nAChR/DPPC complex was ... structure of nAChR embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer and water molecules. A 30-ns CMD simulation ... structure of nAChR embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer and water molecules. A 30-ns CMD simulation ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2211534_pcbi.0040019.g001&req=4
Dynamics of the M2 Helices(A) Bending vibrations of the | Open-i  Dynamics of the M2 Helices(A) Bending vibrations of the | Open-i
... structure of nAChR embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer and water molecules. A 30-ns CMD simulation ... structure of nAChR embedded in a dipalmitoylphosphatidylcholine (DPPC) bilayer and water molecules. A 30-ns CMD simulation ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2211534_pcbi.0040019.g005&req=4
Lucinactant - Wikipedia  Lucinactant - Wikipedia
Lucinactant contains the peptide sinapultide (KL4 acetate), dipalmitoylphosphatidylcholine (DPPC), 1-palmitoyl-2-oleoyl-sn- ... 1] Archived April 20, 2009, at the Wayback Machine. "FDA approves Surfaxin to prevent breathing disorder in premature infants ...
more infohttps://en.wikipedia.org/wiki/Lucinactant
List of MeSH codes (D10) - Wikipedia  List of MeSH codes (D10) - Wikipedia
25-hydroxyvitamin d 2 MeSH D10.570.938.590 --- lanosterol MeSH D10.627.430.354 --- cod liver oil MeSH D10.627.430.450 --- fatty ... 1-butanol MeSH D10.289.110.220 --- chlorobutanol MeSH D10.289.110.855 --- tert-butyl alcohol MeSH D10.289.220.720 --- sodium ... 1,2-dipalmitoylphosphatidylcholine MeSH D10.570.755.375.760.400.840 --- phosphatidylethanolamines MeSH D10.570.755.375.760.400. ... dodecyl sulfate MeSH D10.289.230.250 --- dolichol phosphates MeSH D10.289.600.610 --- 1-octanol MeSH D10.351.801.632 --- ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D10)
WikiGenes - Enlirane - 2-chloro-1-(difluoromethoxy)-1,1,2...  WikiGenes - Enlirane - 2-chloro-1-(difluoromethoxy)-1,1,2...
Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes. ... 1. In the present study the mechanisms were examined by which the neuropeptide galanin modulates the extracellular ... RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT ... Modulation of the inositol 1,4,5-trisphosphate (IP3)-mediated signal transduction pathway by the inhalational anesthetic ...
more infohttps://www.wikigenes.org/e/chem/e/3226.html
Fluids  | Free Full-Text | Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin | HTML  Fluids | Free Full-Text | Comparative Study of PEGylated and Conventional Liposomes as Carriers for Shikonin | HTML
Three types of lipids were assessed (1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-Distearoyl-sn-glycero-3- ... 2-distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DSPG)), separately and in mixtures, forming anionic liposomes with good ... Table 1. Liposome compositions used in the study.. Sample. Type of Lipids. Lipid (mg) a. DSPE-mPEG2000 (mg) b. Cholesterol (mg ... 3.2.2. ζ-Potential. As depicted in Figure 5, the ζ-potential values of most samples remained stable (or reduced slightly) after ...
more infohttps://www.mdpi.com/2311-5521/3/2/36/htm
Intermolecular Hydrogen Bonding between Membrane Lipids | SpringerLink  Intermolecular Hydrogen Bonding between Membrane Lipids | SpringerLink
Akutsu, H., Ikematsu, M., and Kyogoku, Y., 1981, Molecular structure and interaction of dipalmitoyl phosphatidylcholine in ... Differential thermal analysis of dipalmitoylphosphatidylcholine mixtures with fatty acids and sodium soaps, Biophys. J. 37:98a. ... Effect of hydration and sterol addition on Raman spectra of dipalmitoylphos-phatidylcholine multilayers, Biochemistry 19:4429. ... Thermotropic behavior of monoglucocerebroside-dipalmitoylphosphatidylcholine multilamellar liposomes, Biochemistry 18:442. ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-4667-8_1
Molecular dynamics simulations of membrane proteins. - Oxford Neuroscience  Molecular dynamics simulations of membrane proteins. - Oxford Neuroscience
1,2-Dipalmitoylphosphatidylcholine, Algorithms, Bacterial Proteins, Membrane Proteins, Molecular Dynamics Simulation, Potassium ...
more infohttps://www.neuroscience.ox.ac.uk/publications/503317
Holdings: Transformation of the cryobehavior of rye protoplasts by modification of the plasma membrane lipid composition.  Holdings: Transformation of the cryobehavior of rye protoplasts by modification of the plasma membrane lipid composition.
... dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine liposomes had no effect. The increased freezing tolerance was ... 1-palmitoyl- 2-linoleoylphosphatidylcholine, or dioleoylphosphatidylcholine liposomes were somewhat less effective; ...
more infohttps://digital.library.villanova.edu/Record/vudl%3A173985
NAVER Academic > Search...  NAVER Academic > Search...
start page previous page 1 2 3 4 5 6 7 8 9 10 next page end page ... containing the cationic lipid 1-palmitoyl-2-oleoyl-sn-glycero-3 ... 1,2-Dipalmitoylphosphatidylcholine, metabolism, Animals, Catalysis, Cobra Venoms, enzymology, Hydrolysis, Kinetics, Lipid ... 1,2-Dipalmitoylphosphatidylcholine, chemistry, Circular Dichroism, Dimerization, Disulfides, Models, Molecular, Peptides, ... 1,2-Dipalmitoylphosphatidylcholine, metabolism, Carbohydrate Metabolism, Dimyristoylphosphatidylcholine, Gels, Membranes, ...
more infohttps://academic.naver.com/search.naver?field=3&query=Biochimica+et+Biophysica+Acta+1768%EA%B6%8C+5%ED%98%B8&page=4
NAVER Academic > Search...  NAVER Academic > Search...
2005 G D Fu et al. Langmuir : the ACS journal of surfaces and colloids cited 1 times ... 2005 Filip Meersman et al. Langmuir : the ACS journal of surfaces and colloids cited 2 times ... 1,2-Dipalmitoylphosphatidylcholine, chemistry, Adsorption, Desiccation, Dimyristoylphosphatidylcholine, Glass, Lipid Bilayers, ...
more infohttps://academic.naver.com/search.naver?field=3&query=Langmuir+%3A+the+ACS+journal+of+surfaces+and+colloids+21%EA%B6%8C+8%ED%98%B8
Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH | Biochemical Journal  Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH | Biochemical Journal
... dipalmitoyl phosphatidylcholine) and the protease inhibitor cocktail were from Sigma Chemicals. POPC (1-palmitoyl-2-oleoyl ... dipalmitoyl phosphatidylcholine; eCB, endocannabinoid; ER, endoplasmic reticulum; FAAH, fatty acid amide hydrolase; LUV, large ... This followed typical Michaelis-Menten kinetics yielding Km, kcat and kcat/Km values of 16±3 μM, 5.6±0.6 s−1 and 3.5×105 μM−1·s ... Figure 1 Oligomerization state of FAAH in solution Experimental SAXS patterns (A) and pair distribution functions [p(r)] (B) of ...
more infohttp://www.biochemj.org/content/457/3/463
High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. - The Kennedy Institute of...  High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. - The Kennedy Institute of...
... including 2-channel ratiometric TIRF microscopy and fluorescence lifetime imaging, to characterize membrane order at the T cell ... 1,2-Dipalmitoylphosphatidylcholine, Animals, Antigen-Presenting Cells, Humans, Immunological Synapses, Jurkat Cells, ... including 2-channel ratiometric TIRF microscopy and fluorescence lifetime imaging, to characterize membrane order at the T cell ...
more infohttps://www.kennedy.ox.ac.uk/publications/426280
Coarse-grained molecular dynamics simulations of the energetics of helix insertion into a lipid bilayer. - Oxford Neuroscience  Coarse-grained molecular dynamics simulations of the energetics of helix insertion into a lipid bilayer. - Oxford Neuroscience
1,2-Dipalmitoylphosphatidylcholine, Amino Acids, Chlorides, Computer Simulation, Hydrophobic and Hydrophilic Interactions, Ions ...
more infohttps://www.neuroscience.ox.ac.uk/publications/100612
L-α-DiPalmitoyl-Phosphatidylcholine, [DiPalmitoyl-1-14C]-, 10µCi (370kBq) | PerkinElmer  L-α-DiPalmitoyl-Phosphatidylcholine, [DiPalmitoyl-1-14C]-, 10µCi (370kBq) | PerkinElmer
Application of [DiPalmitoyl-1-14C]Phosphatidylcholine can be found in: in vivo evaluation of lipid nanocapsules as a promising ... 10 µCi quantities of L-α-DiPalmitoyl-[DiPalmitoyl-1-14C]-Phosphatidylcholine are available for your research. ... 10 µCi quantities of L-a-DiPalmitoyl-[DiPalmitoyl-1-14C]-Phosphatidylcholine are available for your research. ... effect of pesticide fenitrothion on dipalmitoyl and 1-palmitoyl-2-oleoylphosphatidylcholine bilayers, protein kinase C ...
more infohttp://www.perkinelmer.com/product/phosphatidylcholine-l-dipalmitoyl-dipa-nec682010uc
  • Treatment of differentiated epithelial cells with secretagogues stimulated the secretion of functional surfactant-containing surfactant proteins B and C (SP-B and SP-C). Secreted material was further enriched in this same set of phospholipid species but was characterized by increased contents of short-chain monounsaturated and disaturated species other than dipalmitoyl PC (PC16:0/16:0), principally palmitoylmyristoyl PC (PC16:0/14:0) and palmitoylpalmitoleoyl PC (PC16:0/16:1). (biomedsearch.com)
  • Can reduce H 2 O 2 and short chain organic, fatty acid, and phospholipid hydroperoxides. (uniprot.org)
  • We conclude that three synaptic release functions of syt-1, vesicle priming, spontaneous release clamping, and evoked release triggering, depend on direct SNARE complex interaction. (jneurosci.org)
  • Therefore, vesicle priming, clamping spontaneous release, and eliciting evoked release are three different functions of syt-1 that involve different interaction modes with the SNARE complex. (jneurosci.org)
  • When administered intravenously to C57BL/6J mice bearing melanoma B16F1 tumour at 10 mg kg-1 dose, liposomal bleomycin in combination with hyperthermia (43°C, 30 min or 1 h) exhibited improved anticancer activity as evident by the enhanced volume doubling time and growth delay compared with animals treated with an equivalent dose of free bleomycin with or without hyperthermia. (elsevier.com)
  • Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α 1 β 3 γ 2 GABA A R Transmembrane Domain. (nih.gov)
  • The schematic representation of the simulation system is shown in Figure 1. (nih.gov)
  • Figure 1 ), a chiral pair of natural naphthoquinone compounds, biosynthesized in the roots of more than 150 species of the Boraginaceae plant family (such as lithospermum , Alkanna , Anchusa and Echium) are widely used due to their various pharmacological activities. (mdpi.com)
  • 1,2 Recent studies suggest that statins may also have anti-inflammatory properties. (ahajournals.org)
  • SIGNIFICANCE STATEMENT The function of synaptotagmin-1 (syt-1):soluble NSF attachment protein receptor (SNARE) interactions during neurotransmission remains unclear. (jneurosci.org)
  • or (3) infusions of HDL (8 mg/kg apolipoprotein A-I) on days 1 and 3 of the treatment phase. (ahajournals.org)
  • The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies. (naver.com)
  • An in vitro assay showed that the region I, region II, and region I+II (D51/E52/E55/D166A) mutants markedly reduced the attachment between syt-1 and t-SNARE-carrying vesicles in the absence of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ]. (jneurosci.org)