1,2-Dipalmitoylphosphatidylcholine
Pulmonary Surfactants
Lipid Bilayers
Calorimetry, Differential Scanning
Liposomes
Proteolipids
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Membrane Fluidity
Membranes, Artificial
Phosphatidylcholines
Pulmonary Surfactant-Associated Protein A
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Phosphatidylglycerols
Pulmonary Surfactant-Associated Proteins
Gels
Water
Dimyristoylphosphatidylcholine
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Temperature
Diphenylhexatriene
Thermodynamics
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Surface Properties
Air
Models, Chemical
Pressure
Surface Tension
X-Ray Diffraction
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Tetraphenylborate
Melitten
Pulmonary Surfactant-Associated Protein B
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Phosphatidylethanolamines
Complex Mixtures
Spectroscopy, Fourier Transform Infrared
Calorimetry
The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Cholesterol
4-Chloro-7-nitrobenzofurazan
Microscopy, Atomic Force
A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.
Sphingomyelins
Spectrophotometry, Infrared
Deuterium
Spin Labels
Adsorption
Phospholipases A2
Scattering, Radiation
Molecular Structure
Magnetic Resonance Spectroscopy
Phosphatidylserines
Phospholipid Ethers
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
Fluorescence Polarization
Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
Phospholipases
Models, Molecular
Computer Simulation
Gramicidin
Ergosterol
Phospholipases A
Solutions
Membranes
Micelles
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Physicochemical Phenomena
Chemistry, Physical
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Fatty Alcohols
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Motion
Surface-Active Agents
Pulmonary Alveoli
Permeability
Fluorescent Dyes
Membrane Microdomains
Microscopy, Fluorescence
Structure-Activity Relationship
Diffusion
Choline
Mathematics
Hydrogen Bonding
Fluoresceins
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Lung
Models, Theoretical
Models, Biological
Lucinactant
... contains the peptide sinapultide (KL4 acetate, KLLLLKLLLLKLLLLKLLLLK), dipalmitoylphosphatidylcholine, 1-palmitoyl- ... 2-oleoyl-sn-glycero-3-phosphoglycerol (as the sodium salt), and palmitic acid.[citation needed] The scientific groundwork for ...
List of MeSH codes (D10)
25-hydroxyvitamin d 2 MeSH D10.570.938.590 - lanosterol MeSH D10.627.430.354 - cod liver oil MeSH D10.627.430.450 - fatty acids ... 1-butanol MeSH D10.289.110.220 - chlorobutanol MeSH D10.289.110.855 - tert-butyl alcohol MeSH D10.289.220.720 - sodium dodecyl ... 1,2-dipalmitoylphosphatidylcholine MeSH D10.570.755.375.760.400.840 - phosphatidylethanolamines MeSH D10.570.755.375.760.400. ... sulfate MeSH D10.289.230.250 - dolichol phosphates MeSH D10.289.600.610 - 1-octanol MeSH D10.351.801.632 - triacetin MeSH ...
Stable nucleic acid lipid particle
The SNALPs (around 81 nm in size here) were formulated by spontaneous vesiculation from a mixture of cholesterol, dipalmitoyl phosphatidylcholine ... Further, only 2 of the 6 mice treated had noticeable tumors around the implantation site. Even so, GAPDH, a tumor-derived ... Researchers tested a 1 mg/kg single dose, too, obtaining a 68% silencing of the target gene, indicating dose-dependent ... According to the study, a 2 mg/kg dose of PLK1-specific siRNA administered for 3 weeks to mice implanted with tumors resulted ...
1-Pentadecanol
... investigated as potential amphiphilic species for aiding adsorption of the pulmonary surfactant dipalmitoylphosphatidylcholine ... 1-Pentadecanol is an organic chemical compound classified as an alcohol. At room temperature, it is a white, flaky solid. It is ... Small amounts of 1-pentadecanol have been found (using thin-layer chromatography and GC/MS) to naturally occur in the leaves of ... It, along with 1-hexadecanol, was found to be selectively antimicrobial against P. acnes and not other Gram-positive bacteria ( ...
Tecemotide
... and dipalmitoyl phosphatidylcholine. MPL is a derivative of the lipid A molecule found in the membrane of Gram-negative ... 2 (Supplement 4): S199-201. doi:10.1097/01.JTO.0000282977.65747.30. Merck KGaA to test Stimuvax in breast cancer trial ( ... The 26th modified amino acid, K, is palmityl-lysine (N6-(1-oxohexadecyl)-L-lysine), and the 27th is glycine. In the ... The first 25 amino acids of tecemotide are derived from the mucin 1 (MUC1, carcinoma-associated mucin, episialin, or CD227) ...
Dipalmitoylphosphatidylcholine
... (DPPC) is a phospholipid (and a lecithin) consisting of two C16 palmitic acid groups attached to ... Dipalmitoylphosphatidylcholine (DPPC) is routinely used to formulate some medicines used for treatment of respiratory distress ... "Dipalmitoylphosphatidylcholine - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2019-10-25. Wang, Min; ... is dipalmitoylphosphatidylcholine or DPPC. While DPPC itself already has the ability to reduce the surface tension of the ...
Pulmonary surfactant
40% dipalmitoylphosphatidylcholine (DPPC); ~40% other phospholipids (PC); ~10% surfactant proteins (SP-A, SP-B, SP-C and SP-D ... Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid with two 16-carbon saturated chains and a phosphate group with ... Up to 90% of surfactant DPPC (dipalmitoylphosphatidylcholine) is recycled from the alveolar space back into the type II ... dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. As a medication, pulmonary surfactant is on the WHO Model List ...
Patrick Bouvier Kennedy
The first trials of a potential treatment for HMD, dipalmitoylphosphatidylcholine, were published within a few years but were ... p. 1. Clarke, Thurston (July 1, 2013). "How "Icebergs" John F. and Jackie Kennedy Warmed to One Another After the Death of ... The infant's birth weight was 4 pounds 10+1⁄2 ounces (2.11 kg). He was the first baby to be born to a serving US president and ... 101 (1): 8-12. doi:10.1159/000325162. PMID 21791934. President John F. Kennedy on the Death of His Infant Son Patrick Bouvier ...
Model lipid bilayer
Hollars CW, Dunn RC (July 1998). "Submicron structure in L-alpha-dipalmitoylphosphatidylcholine monolayers and bilayers probed ... doi:10.1007/978-1-62703-782-2_7. ISBN 978-1-62703-781-5. PMID 24395412. Roos C, Kai L, Proverbio D, Ghoshdastider U, Filipek S ... 1666 (1-2): 105-17. doi:10.1016/j.bbamem.2004.04.011. PMID 15519311. Cavagnero S, Dyson HJ, Wright PE (April 1999). "Improved ... 75 (1): 342-53. Bibcode:1998BpJ....75..342H. doi:10.1016/s0006-3495(98)77518-6. PMC 1299703. PMID 9649391. Groves JT, Ulman N, ...
Surfactant protein B
DPPC (dipalmitoylphosphatidylcholine), as mentioned above, is a lipid with very useful stabilizing and compacting attributes. ... The lipid shown to be most needed on this surface (Dipalmitoylphosphatidylcholine) does not easily move to the gas/fluid ... 17 (2): 407-29. doi:10.2741/3935. PMC 3635489. PMID 22201752. Lyra PP, Diniz EM, Abe-Sandes K, Angelo AL, Machado TM, Cardeal M ... 27 (1): 24-9. doi:10.2500/ajra.2013.27.3838. PMID 23406594. S2CID 34564655. Sarker M, Rose J, McDonald M, Morrow MR, Booth V ( ...
Zwitterion
... and pulmonary surfactants such as dipalmitoylphosphatidylcholine. Lauramidopropyl betaine is the major component of ... In the first stage, a proton is transferred from the carboxyl group to a water molecule: H 2 N ( R ) CO 2 H + H 2 O ↽ − − ⇀ H 2 ... ISBN 978-1-285-60719-1.{{cite book}}: CS1 maint: numeric names: authors list (link) Jensen, Jan H.; Gordon, Mark S. (1995). "On ... It is generally assumed that K > 1, that is, that the zwitterion is the predominant amino acid isomer in aqueous solution. It ...
Poractant alfa
... from the content of phosphorus and contains 55 mg of phosphatidylcholine of which 30 mg is dipalmitoylphosphatidylcholine. ... Each milliliter of poractant alfa contains 80 mg of surfactant (extract) that includes 76 mg of phospholipids and 1 mg of ... and that infants treated at birth had similar neurodevelopmental status to untreated controls at a corrected age of 2 years. ...
Phosphatidylcholine
Dipalmitoyl phosphatidylcholine (a.k.a. lecithin) is a major component of pulmonary surfactant and is often used in the L/S ... Animal lung phosphatidylcholine, for example, contains a high proportion of dipalmitoylphosphatidylcholine. Phospholipase D ... 4 (2): 135-7. doi:10.4103/0974-2077.85040. PMC 3183720. PMID 21976907. Kokkinidis DG, Bosdelekidou EE, Iliopoulou SM, Tassos AG ... Phosphatidylcholines at the US National Library of Medicine Medical Subject Headings (MeSH) [1] (CS1 maint: location, Articles ...
Respiratory Distress Syndrome Guidelines: Respiratory Distress Syndrome Clinical Practice Guidelines (2019), Resources
Dipalmitoyl phosphatidylcholine (DPPC), tripalmitin, SP-B , 0.5%, SP-C 99% of TP wt/wt ... Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med. 2007. 357:1179-89. [QxMD MEDLINE Link ... Outcome at 2 years of age of infants from the DART study: a multicenter, international, randomized, controlled trial of low- ... Using a mask or nasal prongs, continuous positive airway pressure (CPAP) of at least 6 cm H2O should be used to stabilize ...
Atelectasis: Practice Essentials, Background, Pathophysiology
The surfactant has phospholipid dipalmitoyl phosphatidylcholine, which prevents lung collapse by reducing the surface tension ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. The ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. ... 2] Timely medical intervention with fiberoptic bronchoscopy with bronchoalveolar lavage in patients, particularly children, ...
Respiratory Distress Syndrome: Background, Etiology, Epidemiology
Dipalmitoyl phosphatidylcholine (DPPC), or lecithin, is functionally the principle phospholipid. Phosphatidylglycerol makes up ... Dipalmitoyl phosphatidylcholine (DPPC), tripalmitin, SP-B , 0.5%, SP-C 99% of TP wt/wt ... Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med. 2007. 357:1179-89. [QxMD MEDLINE Link ... Treat PDA with ibuprofen or indomethacin, which can be repeated during the first 2 weeks if the PDA reopens. [8] In refractory ...
Respiratory Distress Syndrome Workup: Approach Considerations, Procedures, Blood Gases
Dipalmitoyl phosphatidylcholine (DPPC), tripalmitin, SP-B , 0.5%, SP-C 99% of TP wt/wt ... Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med. 2007. 357:1179-89. [QxMD MEDLINE Link ... Outcome at 2 years of age of infants from the DART study: a multicenter, international, randomized, controlled trial of low- ... Transcutaneous CO2 monitors should be used in infants with ongoing respiratory distress to monitor ventilation if it correlates ...
Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung...
The quality of case-associated BAL specimens was assessed by measuring dipalmitoylphosphatidylcholine (DPPC), the principal ... Benjamin C. Blount, PhD1,*; Mateusz P. Karwowski, MD1,*; Maria Morel-Espinosa, PhD1; Jon Rees, PhD1; Connie Sosnoff, MA1; ... 1Division of Laboratory Sciences, National Center for Environmental Health, CDC; 2Office of the Director, National Center for ... PhD1; Cliff Watson, PhD1; Tiffany Seyler, PhD1; Baoyun Xia, PhD1; David Chambers, PhD1; Peter Briss, MD2; Brian A. King, PhD3; ...
Atelectasis: Practice Essentials, Background, Pathophysiology
The surfactant has phospholipid dipalmitoyl phosphatidylcholine, which prevents lung collapse by reducing the surface tension ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. The ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. ... 2] Timely medical intervention with fiberoptic bronchoscopy with bronchoalveolar lavage in patients, particularly children, ...
NIOSHTIC-2 Search Results - Full View
... and PBS containing dipalmitoyl phosphatidylcholine (DPPC) and/or mouse serum albumin. To assess and compare how these various ... Advanced Search Search Help About NIOSHTIC-2 Feedback Terms: 'ultrafine*' OR ('nano*' AND 'particle*') OR 'nanotech*' OR ' ... NIOSHTIC-2 Publications Search. Search Results. New Search. ...
Atelectasis: Practice Essentials, Background, Pathophysiology
The surfactant has phospholipid dipalmitoyl phosphatidylcholine, which prevents lung collapse by reducing the surface tension ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. The ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. ... 2] Timely medical intervention with fiberoptic bronchoscopy with bronchoalveolar lavage in patients, particularly children, ...
Value Set Details
R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol. (R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3- ... 1,2-Dimethylhydrazine. 1,2-Dimethylhydrazine (Structural Class). NDF-RT (Drug Classification). Drug Classes (NDF-RT). Details. ... 1,4-alpha-Glucan Branching Enzyme (Structural Class). NDF-RT (Drug Classification). Drug Classes (NDF-RT). Details. ... 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (Structural Class). NDF-RT (Drug Classification). Drug Classes (NDF-RT). Details ...
NIOSHTIC-2 Search Results - Full View
... and dipalmitoyl phosphatidylcholine (DPPC). To assess and compare how the various suspension medias dispersed the particles, ... Advanced Search Search Help About NIOSHTIC-2 Feedback Terms: 'ultrafine*' OR ('nano*' AND 'particle*') OR 'nanotech*' OR ' ... NIOSHTIC-2 Publications Search. Search Results. New Search. ...
Code System Concept
Dipalmitoylphosphatidylcholine measurement (procedure) {104644005 , SNOMED-CT } Lecithin phosphorus measurement (procedure) { ...
Respiratory Distress Syndrome: Background, Etiology, Epidemiology
Dipalmitoyl phosphatidylcholine (DPPC), or lecithin, is functionally the principle phospholipid. Phosphatidylglycerol makes up ... Dipalmitoyl phosphatidylcholine (DPPC), tripalmitin, SP-B , 0.5%, SP-C 99% of TP wt/wt ... Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med. 2007. 357:1179-89. [QxMD MEDLINE Link ... Treat PDA with ibuprofen or indomethacin, which can be repeated during the first 2 weeks if the PDA reopens. [8] In refractory ...
Respiratory Distress Syndrome Differential Diagnoses
Dipalmitoyl phosphatidylcholine (DPPC), tripalmitin, SP-B , 0.5%, SP-C 99% of TP wt/wt ... Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Engl J Med. 2007. 357:1179-89. [QxMD MEDLINE Link ... Outcome at 2 years of age of infants from the DART study: a multicenter, international, randomized, controlled trial of low- ... Table 2. Surfactant Preparations: Type, Source, Composition, Dosages, and Other Information. *Table 3. Results of a Meta- ...
NIOSHTIC-2 Search Results - Full View
... and PBS containing dipalmitoyl phosphatidylcholine (DPPC) and/or mouse serum albumin. To assess and compare how these various ...
Value Set Details
R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol. (R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3- ... 1,2-Dimethylhydrazine. 1,2-Dimethylhydrazine (Structural Class). NDF-RT (Drug Classification). Drug Classes (NDF-RT). Details. ... 1,4-alpha-Glucan Branching Enzyme (Structural Class). NDF-RT (Drug Classification). Drug Classes (NDF-RT). Details. ... 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (Structural Class). NDF-RT (Drug Classification). Drug Classes (NDF-RT). Details ...
1,2-Dipalmitoylphosphatidylcholine
Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D
2ygp.1 | SWISS-MODEL Template Library
... entry for 2ygp.1. WIF domain-EGF-like domain 1 Met77Trp of human Wnt inhibitory factor 1 in complex with 1,2- ... dipalmitoylphosphatidylcholine ... 2 x CA: CALCIUM ION(Non-covalent). CA.3: 4 residues within 4Å:* ... 2 x SPD: SPERMIDINE(Non-covalent). SPD.4: 8 residues within 4Å:*. Chain A: M.32, T.36, H.37, F.39, K.135, T.136, P.137, Q.138 ... 2 x PCF: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE(Non-covalent). PCF.1: 23 residues within 4Å:*. Chain A: L.7, I.9, L.17, I.18, I. ...
Lucinactant - Wikipedia
NIOSHTIC-2 Search Results - Full View
Find Research outputs - Augusta University Research Profiles
Yu, R. K., Itoh, T., Yohe, H. C. & Macala, L. J., Sep 19 1983, In: Brain Research. 275, 1, p. 47-52 6 p.. Research output: ... Xia, T., Gao, L., Yu, R. K. & Zeng, G., May 8 2003, In: Gene. 309, 2, p. 117-123 7 p.. Research output: Contribution to journal ... Zhang, Q., Schwade, M., Schafer, P., Weintraub, N. & Young, L., Apr 2020, In: Cardiology Research. 11, 2, p. 97-105 9 p.. ... Padilla, J., Harris, R. A., Rink, L. D. & Wallace, J. P., 2008, In: Vascular Medicine. 13, 2, p. 105-111 7 p.. Research output ...
Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm...
Results: Dipalmitoyl phosphatidylcholine values in lung were 0.22 ± 0.27 μg/mg of total protein in preterm versus 1.96 ± 0.57 ... Results: Dipalmitoyl phosphatidylcholine values in lung were 0.22 ± 0.27 μg/mg of total protein in preterm versus 1.96 ± 0.57 ... Results: Dipalmitoyl phosphatidylcholine values in lung were 0.22 ± 0.27 μg/mg of total protein in preterm versus 1.96 ± 0.57 ... Results: Dipalmitoyl phosphatidylcholine values in lung were 0.22 ± 0.27 μg/mg of total protein in preterm versus 1.96 ± 0.57 ...
A reduction-triggered delivery by a liposomal carrier possessing membrane-permeable ligands and a detachable coating -...
María Isabel Soriano Torres - Science Portal | Universidad de La Laguna
Osteogenic effect of local, long versus short term BMP-2 delivery from a novel SPU-PLGA-βTCP concentric system in a critical ... Material-related effects of BMP-2 delivery systems on bone regeneration Acta Biomaterialia, Vol. 8, Núm. 2, pp. 781-791 ... Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: The effect of 1,2- ... dipalmitoylphosphatidylcholine Journal of Controlled Release, Vol. 51, Núm. 2-3, pp. 143-152 ...
KU-KIST Graduate School of Converging Science and Technology - Research output - Korea University
Choi, K. M., Kim, K., Kwon, I. C., Kim, I. S. & Ahn, H. J., 2013 Jan 7, In: Molecular Pharmaceutics. 10, 1, p. 18-25 8 p.. ... Kim, M. S., Kim, S. K., Lee, J. Y., Cho, S. H., Lee, K. H., Kim, J. & Lee, S. S., 2008 Feb, In: Macromolecular Research. 16, 2 ... Woo, J. U., Kweon, S. H., Im, M., Lee, W. H., Kang, C. Y. & Nahm, S., 2017 Dec 1, In: Ceramics International. 43, 17, p. 15089- ... Lee, S. S., Min, S. S., Ahn, T. O. & Jho, J. Y., 1997, In: Polymer (Korea). 21, 2, p. 208-214 7 p.. Research output: ...
Verhandlungen der Deutschen Physikalischen Gesellschaft
In this research, we report the novel formation process of supported Dipalmitoylphosphatidylcholine (DPPC) bilayers evaporated ... Catolica de Chile, Santiago, Chile - 2Faculty of Chemistry and CIEN-UC, P. Univ. Catolica de Chile, Santiago, Chile - 3 ... Sebastian Molina1, Maria Jose Retamal2, Nicolas Moraga1, Hugo Zelada1, Marco A. Soto-Arriaza2, Tomas P. Corrales3, and •Ulrich ... 1Institute of Physics and CIEN-UC, P. Univ. ...
Recent trends in protein and peptide drug delivery systems
| Asian Journal of Pharmaceutics (AJP)
2 (2009): Apr-June * Himanshu Gupta, Anubhav Anand1, Rakesh Pundir, C S Pandian, Shubhini Saraf, Fabrication of cefuroxime- ... interleukin-2 at its glycosylation site. Biotechnology 1990;8:343-6. Harris JM, Martin NE, Modi M. Pegylation: A novel process ... and pulmonary safety of inhaled insulin during 2-years of outpatient therapy. Paper (A101) published in the American Diabetes ... glycemic control in patients with type 2 diabetes failing combination oral agents: A 3-month, randomized, comparative trial for ...
Bipolar Tetraether Lipids: Chain Flexibility and Membrane Polarity Gradients from Spin-Label Electron Spin Resonance
For comparison, similar measurements have been carried out on aqueous dispersions of diacyl reference lipid dipalmitoyl phosphatidylcholine ... For comparison, similar measurements have been carried out on aqueous dispersions of diacyl reference lipid dipalmitoyl phosphatidylcholine ... the tetraether P2 lipids mix well with dipalmitoyl phosphatidylcholine lipids and stabilize conventional bilayer membranes. The ... the tetraether P2 lipids mix well with dipalmitoyl phosphatidylcholine lipids and stabilize conventional bilayer membranes. The ...
CUBOSOMES: A BOON FOR COSMECEUTICALS AND TOPICAL DRUG DELIVERY
| International Journal of Pharmacy and Pharmaceutical...
doi: 10.1007/978-1-4939-1417-3_7. Kaur SD, Singh G, Singh G, Singhal K, Kant S, Bedi N. Cubosomes as a potential nanocarrier ... 2018;5(1):76-81. doi: 10.30574/ gscbps.2018.5.1.0089. Bender J, Ericson MB, Merclin N, Iani V, Rosen A, Engstrom S, Moan J. ... 2021;10(3):1-7. Yara EE, Mona KY. Challenge of cubosomes in advanced and targeting drug delivery systems. Int J Sci Eng Res. ... 2019;1(12):119-29. He H, Rahimi K, Zhong M, Mourran A, Luebke DR, Nulwala HB. Cubosomes from hierarchical self-assembly of poly ...
Publikationen | Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Li, J. B.; Zhao, J.; Wu, J.; Miller, R.: Interaction of human serum albumin with dipalmitoylphosphatidylcholine in spread ... Li, J. B.; Zhao, J.; Miller, R.: Morphology and thermodynamics of dipalmitoylphosphatidylcholine monolayers penetrated by β- ... Hochschulschrift - Doktorarbeit (1). 2000. Hochschulschrift - Doktorarbeit Zhao, J.: Protein penetration into 2 D aggregating. ...
Find Research outputs - Augusta University Research Profiles
... for the morphology of self-assembled structures of glycosphingolipids and their mixtures with dipalmitoylphosphatidylcholine. ... Ripps, H., Peachey, N. S., Xu, X., Nozell, S. E., Smith, S. B. & Liou, G. I., 2000, In: Visual Neuroscience. 17, 1, p. 97-105 9 ... Stacy, R., Eroglu, A., Fowler, A., Biggers, J. & Toner, M., Feb 2006, In: Cryobiology. 52, 1, p. 99-107 9 p.. Research output: ... Gibbons, D. L., Pricl, S., Kantarjian, H., Cortes, J. & Quintás-Cardama, A., Jan 15 2012, In: Cancer. 118, 2, p. 293-299 7 p.. ...
Chemical CAS Number List from 63-45-6 to 63-91-2 --ChemIndex
The 3-hydroxy group and 4,5-trans double bond of sphingomyelin are essential for modulation of galactosylceramide transmembrane...
... and dipalmitoylphosphatidylcholine, a popular model "raft lipid. The transbilayer distributions of the SPM analogs and SPM in ... and dipalmitoylphosphatidylcholine, a popular model "raft lipid. The transbilayer distributions of the SPM analogs and SPM in ... and dipalmitoylphosphatidylcholine, a popular model "raft lipid. The transbilayer distributions of the SPM analogs and SPM in ... and dipalmitoylphosphatidylcholine, a popular model {"}raft lipid. The transbilayer distributions of the SPM analogs and SPM ...
Medical Science Monitor | Preliminary evaluation of the capacity of Surface-Active Phospholipids to provide semipermeability in...
Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung...
The quality of case-associated BAL specimens was assessed by measuring dipalmitoylphosphatidylcholine (DPPC), the principal ... Benjamin C. Blount, PhD1,*; Mateusz P. Karwowski, MD1,*; Maria Morel-Espinosa, PhD1; Jon Rees, PhD1; Connie Sosnoff, MA1; ... 1Division of Laboratory Sciences, National Center for Environmental Health, CDC; 2Office of the Director, National Center for ... PhD1; Cliff Watson, PhD1; Tiffany Seyler, PhD1; Baoyun Xia, PhD1; David Chambers, PhD1; Peter Briss, MD2; Brian A. King, PhD3; ...
Photo-Enhanced Delivery of Genetic Material Using Curcumin Loaded Composite Nanocarriers
Dipalmitoylphosphatidylcholine (DPPC), cholesterol and curcumin. Since the transfection efficiency is highly dependent on the ... Phone : +1 415-690-1011 E-mail: [email protected] Offshore. Clinics in Oncology SN Techno Space, 1-98/4/154, First Floor, Hi- ... 2004; 56(1): 95-115.. *Ohtsuki T, Miki S, Kobayashi S, Haraguchi T, Nakata E, Hirakawa K, et al. The molecular mechanism of ... 2011; 1(1): 23-30.. *Thomas M, Lu JJ, Ge Q, Zhang C, Chen J, Klibanov AM. Full deacylation of polyethylenimine dramatically ...
Altmetric - Photo activation of HPPH encapsulated in “Pocket” liposomes triggers multiple drug release and...
... recently reported laser-triggered release of photosensitive compounds from liposomes containing dipalmitoylphosphatidylcholine ... In this study we have encapsulated the red light activatable anticancer photodynamic therapy drug 2-(1-Hexyloxyethyl)-2-devinyl ... DPPC) and 1,2 bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC). We hypothesized that the permeation of ...
A Tribological Investigation of Carbon-Carbon Composites and the Effect of Roughness and Waviness Parameters on Friction...
Professor Simon Jackson - University of Plymouth
Tonks A, Morris RH, Price AJ, Thomas AW, Jones KP & Jackson SK (2001) Dipalmitoylphosphatidylcholine modulates inflammatory ... 2003) Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine J Leukoc Biol ... in monocytic cells is inhibited by dipalmitoyl phosphatidylcholine via inhibition of enzymes of the remodelling pathway BLOOD ... 1) Evans M, Anderson RA, Graham J, Ellis GR, Morris K, Davies S, Jackson SK, Lewis MJ, Frenneaux MP & Rees A (2000) ...
Martin Caffrey : School of Biochemistry and Immunology - Trinity College Dublin
... in hydrated dipalmitoylphosphatidylcholine. A time-resolved x-ray diffraction study using microwave-induced temperature-jumps ... serotonin receptor bound to an inverse agonist, Cell Discovery, 4, (1), 2018, p12- Journal Article, 2018 DOI TARA - Full Text ... A Host Lipid Screen, CRYSTAL GROWTH & DESIGN, 11, (2), 2011, p530-537 Journal Article, 2011 TARA - Full Text DOI ... Raman, P., Cherezov, V., Caffrey, M., The Membrane Protein Data Bank., Cellular and Molecular Life Sciences, 63, (1), 2006, p36 ...
Atelectasis: Practice Essentials, Background, Pathophysiology
The surfactant has phospholipid dipalmitoyl phosphatidylcholine, which prevents lung collapse by reducing the surface tension ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. The ... 1] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. ... 2] Timely medical intervention with fiberoptic bronchoscopy with bronchoalveolar lavage in patients, particularly children, ...
DPPC11
- In this research, we report the novel formation process of supported Dipalmitoylphosphatidylcholine (DPPC) bilayers evaporated directly on bare silicon surfaces by means of physical vapor deposition, without the use of a polymer cushions or solvents, i.e. in a completely dry process. (dpg-verhandlungen.de)
- The cationic polyplexes were encapsulated inside anionic liposomes formulated using 1,2-Dioleoyl-sn-glycero- 3-phosphoethanolamine (DOPE), Dipalmitoylphosphatidylcholine (DPPC), cholesterol and curcumin. (clinicsinoncology.com)
- The quality of case-associated BAL specimens was assessed by measuring dipalmitoylphosphatidylcholine (DPPC), the principal phospholipid in naturally-occurring lung surfactant: the presence of acceptable levels of DPPC confirms that the lavage procedure recovered adequate pulmonary epithelial fluid. (cdc.gov)
- We recently reported laser-triggered release of photosensitive compounds from liposomes containing dipalmitoylphosphatidylcholine (DPPC) and 1,2 bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC). (altmetric.com)
- 9012} Its PLA2 activity is calcium-independent, functions optimally in acidic (pH = 4) conditions, and facilitates the intracellular processing of surfactant lipids, including dipalmitoylphosphatidylcholine (DPPC). (bertin-bioreagent.com)
- For exposures 1 - 4 dipalmitoylphosphatidylcholine (DPPC) membranes in the liquid- condensed (LC) phase with an average superficial pressure of 28.5-32 mN/m were used. (emf-portal.org)
- By adsorbing to the air-water interface of alveoli with the hydrophilic head groups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant, dipalmitoylphosphatidylcholine (DPPC), reduces surface tension . (en-academic.com)
- The interaction of Ca2+, with dipalmitoyl phosphatidylcholine (DPPC) model membranes was studied in the presence and absence of vitamin D-2 by using Fourier transform infrared spectroscopy. (metu.edu.tr)
- Addition of vitamin D-2 and/or Ca2+ into pure DPPC liposomes shifts the phase transition to higher temperature, orders and decreases the dynamics of the acyl chains in both phases and does not induce hydrogen bond formation in the interfacial region. (metu.edu.tr)
- 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) was used to represent a naturally occurring phospholipid. (datapdf.com)
- I will be working on molecular dynamics simulations of Dipalmitoylphosphatidylcholine (DPPC), which is a key component of pulmonary surfactant. (northeastern.edu)
Lipid5
- The decrease of the molecular mobility was observed from 1 mM Ca 2+ , at which the number of bound Ca 2+ is much less than that of the total lipid molecules. (elsevier.com)
- Figure 2: Graphene nanosheet insertion and lipid extraction. (nature.com)
- Molecular insight for the effect of lipid bilayer environments on thrombospondin-1 and calreticulin interactions. (uab.edu)
- Impact of A2T and D23N Mutations on Tetrameric Aβ42 Barrel within a Dipalmitoylphosphatidylcholine Lipid Bilayer Membrane by Replica Exchange Molecular Dynamics. (ibpc.fr)
- Methods were developed for the preparation of supported bilayer lipid membranes (1), and it was discovered that dried thin films of phospholipids spontaneously hydrate to yield lipid vesicles (2). (pdfhall.com)
Membranes3
- At a mole ratio of 1:2, the tetraether P2 lipids mix well with dipalmitoyl phosphatidylcholine lipids and stabilize conventional bilayer membranes. (unical.it)
- Interaction between Ca2+ and dipalmitoylphosphatidylcholine membranes. (elsevier.com)
- The effect of Ca 2+ on the molecular mobility in dipalmitoylphosphatidylcholine membranes was studied by steady-state and time-resolved measurements of fluorescence anisotropy. (elsevier.com)
Liposomes1
- In this study we have encapsulated the red light activatable anticancer photodynamic therapy drug 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) (Ex/Em410/670 nm) together with calcein (Ex/Em490/517 nm) as a marker for drug release in Pocket liposomes. (altmetric.com)
Monolayers3
- Morphology and thermodynamics of dipalmitoylphosphatidylcholine monolayers penetrated by β-casein and β-lactoglobulin at the air/water interface. (mpg.de)
- Interaction of human serum albumin with dipalmitoylphosphatidylcholine in spread monolayers at the air/water interface. (mpg.de)
- The factors 2 arise from the contribution of the two monolayers of the bilayer. (pdfhall.com)
Vesicles4
- However, inclusion of 2 and 10 mol % dihydroSPM in SPM/ POPC ( 1: 1) vesicles mitigated and completely abrogated the effect of SPM on the transbilayer distribution of GalCer. (abo.fi)
- In this study, the center-of-mass diffusion and shape fluctuations of large unilamellar 1-palmitoyl-2-oleyl-sn-glycero-phosphatidylcholine vesicles prepared by extrusion are studied by means of neutron spin echo in combination with dynamic light scattering. (uni-bielefeld.de)
- The difference in skin interaction between occlusive and non-occlusive application is of importance for deformable vesicles 2 . (ijpsr.com)
- When native GM1 (49.3% C18:1 and 50.7% C20:1 LCB, respectively), was inserted in dipalmitoylphosphatidylcholine vesicles and partially oxidized (10%), the proportion of C18:1 and C20:1 species in the oxidized GM1 was 59.6% and 40.4%, respectively, suggesting a preferential action of the enzyme on the shorter species. (unimib.it)
Lipids2
- Analyses of THC-containing product samples by FDA and state public health laboratories have identified potentially harmful constituents in these products, such as vitamin E acetate, medium chain triglyceride oil (MCT oil), and other lipids ( 2 , 3 ) (personal communication, D.T. Heitkemper, FDA Forensic Chemistry Center, November 2019). (cdc.gov)
- CUROSURF is an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids) and 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B and SP-C). (rxlist.com)
Metabolism1
- 1993. In vitro percutaneous absorption and metabolism in man of 2-chloro-4-ethylamino-6-isopropylamine-s-triazine (atrazine). (cdc.gov)
Phospholipid2
- A dipalmitoylphosphatidylcholine is a phospholipid consisting of two palmitic acids, the major constituent of pulmonary surfactant. (lotsofwords.com)
- Bottom left: the phospholipid 1-palmitoyl-2-oleoylphosphatidylcholine ('''POPC''') Center right: sodium bis(2-ethylhexyl)sulfosuccinate ('''AOT''') AOT is a rare surfactant - it is soluble and active in both oil and water. (harvard.edu)
Fluorescence1
- The fluorescence anisotropy decay of 1,6-diphenyl-1,3,5-hexatriene in the hydrocarbon region indicated that the free volume of molecular rotation became more restricted when the Ca 2+ concentration was increased. (elsevier.com)
Morphology2
- Figure 1: Morphology of E. coli exposed to graphene oxide nanosheets. (nature.com)
- The weight percent of ZrO 2 in coatings and the surface morphology of coatings were examined. (asme.org)
Acetate1
- Lucinactant contains the peptide sinapultide (KL4 acetate, KLLLLKLLLLKLLLLKLLLLK), dipalmitoylphosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (as the sodium salt), and palmitic acid. (wikipedia.org)
20181
- 2018;7(2):109-21, doi: 10.1680/ jbibn.16.00039. (innovareacademics.in)
20171
- Akademia Górniczo-Hutnicza, Kraków, Wydział Fizyki i Informatyki Stosowanej, umowa zawarta 1 listopada 2017 (dr Jacek Nizioł). (edu.pl)
20211
- [2] [5] In the United Kingdom a year of treatment costs the NHS about £196,000 as of 2021. (mdwiki.org)
Proteins2
- Among the four surfactant apoproteins identified, surfactant protein B (SP-B) and SP-C are two small hydrophobic proteins that make up 2-4% of the surfactant mass and are present in commercially available surfactant preparations. (medscape.com)
- The observed crystal packing of the domains provides a plausible model for the association of multiple tandemly linked EGF-like domains in proteins such as fibrillin-1, Notch, and protein S. This model is consistent with the known functional data and suggests a general biological role for these domains. (embl.de)
Interaction1
- Effects of altered restraints in β1 integrin on the force-regulated interaction between the glycosylated I-like domain of β1 integrin and fibronectin III9-10: a steered molecular dynamic study. (uab.edu)
Hydrophobic1
- The bilayer is a two-dimensional fluid composed of amphiphiles with their hydrophilic head groups exposed to the aqueous solutions and their hydrophobic tails aggregated to exclude water (Fig. 1). (pdfhall.com)
Behavior4
- Influence of tungsten disulfide particles (WS 2 ) on the friction and wear behavior of Mg-AZ91 forms the objective of this work. (asme.org)
- Tribo-oxidation mechanism and tribological behavior of TaC-20 vol%SiC composites from 25 to 800 °C coupled with aluminum oxide (Al 2 O 3 ) and cemented carbide (WC-Co) were investigated. (asme.org)
- The results show that ultrasonic agitation can greatly affect the microstructure and the tribological behavior of Ni-ZrO 2 nanocomposite coatings. (asme.org)
- Therefore, the Ni-ZrO 2 nanocomposite coating by ultrasonic electrodeposition exhibits high microhardness and excellent tribological behavior. (asme.org)
20011
- Adv Drug Deliv Rev. 2001;47(2-3):229-50. (innovareacademics.in)
Alveolar1
- [ 1 ] Atelectasis occurs when the alveoli (small air sacs) within the lung become deflated or fill with alveolar fluid. (medscape.com)
Nanoparticles3
- Ni-ZrO 2 nanocomposite coatings were fabricated by electrodeposition from a modified Watt's type electrolyte containing ZrO 2 nanoparticles, where an ultrasonic field was imposed during electrodeposition process. (asme.org)
- The dispersed ZrO 2 nanoparticles in coatings and ultrasonic agitation during electrodeposition synthetically contribute to the grain refinement of the coatings. (asme.org)
- In general, the improvement in friction and wear properties of Ni-ZrO 2 nanocomposite coatings can be attributed to the homogeneously dispersed ZrO 2 nanoparticles and the finer-grained structure. (asme.org)
Phosphatidylcholine2
- Possible changes in surface properties of 1,2-dipalmitoyl- phosphatidylcholine (DPL) and lung surfactant induced by kaolin (1332587) dust were investigated using a Wilhelmy surface balance. (cdc.gov)
- Each milliliter of suspension contains 80 mg of poractant alfa (surfactant extract) that includes 76 mg of phospholipids and 1 mg of protein of which 0.45 mg is SP-B and 0.59 mg is SP-C. The amount of phospholipids is calculated from the content of phosphorus and contains 55 mg of phosphatidylcholine of which 30 mg is dipalmitoylphosphatidylcholine. (rxlist.com)
Photodynamic1
- With a risk rate 1 in 75 women getting ovarian cancer and a mortality rate of 1 in 100, conjugative tumour therapeutics involving gene therapy and photodynamic therapy offer a promising adjunct to the prevailing therapies. (clinicsinoncology.com)
20192
- 2019;1(12):119-29. (innovareacademics.in)
- Based on data collected as of October 15, 2019, 86% of 867 EVALI patients reported using tetrahydrocannabinol (THC)-containing products in the 3 months preceding symptom onset ( 1 ). (cdc.gov)
0.451
- Short stack design was based on electrochemical data obtained at 0.60 V was 0.45 A/cm(2) from performance tests. (metu.edu.tr)
Residues1
- Molecular and Structural Insight for the Role of Key Residues of Thrombospondin-1 and Calreticulin in Thrombospondin-1- Calreticulin Binding. (uab.edu)
Grain refinement2
Chemistry1
- Catolica de Chile, Santiago, Chile - 2 Faculty of Chemistry and CIEN-UC, P. Univ. (dpg-verhandlungen.de)
Biol2
- Stud Univ Babes-Bolyai, Biol 24(2):32-35. (cdc.gov)
- Proc Soc Exp Biol Med 1957;95:170-2. (pneumon.org)
Copolymers1
- A summary of vesicle-forming block copolymers is given in Table 1. (pdfhall.com)
Composite2
Analyses1
- Role of Altered Sialylation of the I-like Domain of β1 Integrin in the Binding of Fibronectin to β1 Integrin: Thermodynamics and Conformational Analyses. (uab.edu)
Microhardness2
- Higher the microhardness of the (Al 2 O 3 + TiN)/Ti6Al4V clad layer in the cladding zone compared with other clad layer compositions such as Ti6Al4V, Al 2 O 3 /Ti6Al4V, and TiN/Ti6Al4V, it is varied from 1130HV 0.2 to 1222HV 0.2 , and the average microhardness is about 990.57HV 0.2 which is 175% improvement compared with the substrate. (asme.org)
- The microhardness and tribological properties of Ni-ZrO 2 nanocomposite coatings and pure Ni coating were investigated. (asme.org)