1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.Pulmonary Surfactants: Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.Lipid Bilayers: Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.Calorimetry, Differential Scanning: Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Proteolipids: Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.Membrane Fluidity: The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.Membranes, Artificial: Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.Phosphatidylcholines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.Phase Transition: A change of a substance from one form or state to another.Pulmonary Surfactant-Associated Protein A: An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.Phosphatidylglycerols: A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.Pulmonary Surfactant-Associated Proteins: Proteins found in the LUNG that act as PULMONARY SURFACTANTS.Gels: Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.Biophysics: The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Dimyristoylphosphatidylcholine: A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.Biophysical Phenomena: The physical characteristics and processes of biological systems.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Diphenylhexatriene: A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Air: The mixture of gases present in the earth's atmosphere consisting of oxygen, nitrogen, carbon dioxide, and small amounts of other gases.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Surface Tension: The force acting on the surface of a liquid, tending to minimize the area of the surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Tetraphenylborate: An anionic compound that is used as a reagent for determination of potassium, ammonium, rubidium, and cesium ions. It also uncouples oxidative phosphorylation and forms complexes with biological materials, and is used in biological assays.Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.Liquid Crystals: Materials in intermediate state between solid and liquid.Pulmonary Surfactant-Associated Protein B: A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Phosphatidylethanolamines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.Complex Mixtures: Mixtures of many components in inexact proportions, usually natural, such as PLANT EXTRACTS; VENOMS; and MANURE. These are distinguished from DRUG COMBINATIONS which have only a few components in definite proportions.Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Calorimetry: The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.4-Chloro-7-nitrobenzofurazan: A benzofuran derivative used as a protein reagent since the terminal N-NBD-protein conjugate possesses interesting fluorescence and spectral properties. It has also been used as a covalent inhibitor of both beef heart mitochondrial ATPase and bacterial ATPase.Microscopy, Atomic Force: A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.Sphingomyelins: A class of sphingolipids found largely in the brain and other nervous tissue. They contain phosphocholine or phosphoethanolamine as their polar head group so therefore are the only sphingolipids classified as PHOSPHOLIPIDS.Spectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Deuterium: Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.Spin Labels: Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)2-Naphthylamine: A naphthalene derivative with carcinogenic action.Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.Phospholipases A2: Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.Scattering, Radiation: The diversion of RADIATION (thermal, electromagnetic, or nuclear) from its original path as a result of interactions or collisions with atoms, molecules, or larger particles in the atmosphere or other media. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Phosphatidylserines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.Phospholipid Ethers: Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.Fluorescence Polarization: Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.Phospholipases: A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Laurates: Salts and esters of the 12-carbon saturated monocarboxylic acid--lauric acid.Kinetics: The rate dynamics in chemical or physical systems.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Gramicidin: A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.Ergosterol: A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.Phospholipases A: Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Membranes: Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.Static Electricity: The accumulation of an electric charge on a objectMicelles: Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.Electron Spin Resonance Spectroscopy: A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.Physicochemical Phenomena: The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.Chemistry, Physical: The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Fatty Alcohols: Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Motion: Physical motion, i.e., a change in position of a body or subject as a result of an external force. It is distinguished from MOVEMENT, a process resulting from biological activity.Surface-Active Agents: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Membrane Microdomains: Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Diffusion: The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.Choline: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.Mathematics: The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Particle Size: Relating to the size of solids.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Lucinactant... contains the peptide sinapultide (KL4 acetate), dipalmitoylphosphatidylcholine (DPPC), 1-palmitoyl-2-oleoyl-sn- ... 1] Archived April 20, 2009, at the Wayback Machine. "FDA approves Surfaxin to prevent breathing disorder in premature infants ...
25-hydroxyvitamin d 2 MeSH D10.570.938.590 --- lanosterol MeSH D10.627.430.354 --- cod liver oil MeSH D10.627.430.450 --- fatty ... 1-butanol MeSH D10.289.110.220 --- chlorobutanol MeSH D10.289.110.855 --- tert-butyl alcohol MeSH D10.289.220.720 --- sodium ... 1,2-dipalmitoylphosphatidylcholine MeSH D10.570.755.375.760.400.840 --- phosphatidylethanolamines MeSH D10.570.755.375.760.400. ... dodecyl sulfate MeSH D10.289.230.250 --- dolichol phosphates MeSH D10.289.600.610 --- 1-octanol MeSH D10.351.801.632 --- ...
The SNALPs (around 81 nm in size here) were formulated by spontaneous vesiculation from a mixture of cholesterol, dipalmitoyl phosphatidylcholine ... Further, only 2 of the 6 mice treated had noticeable tumors around the implantation site. Even so, GAPDH, a tumor-derived ... Researchers tested a 1 mg/kg single dose, too, obtaining a 68% silencing of the target gene, indicating dose-dependent ... According to the study, a 2 mg/kg dose of PLK1-specific siRNA administered for 3 weeks to mice implanted with tumors resulted ...
... and dipalmitoyl phosphatidylcholine (DPPC) Function: Structure of the liposome Enhances uptake by APCs The antigen tecemotide ... The first 25 amino acids of tecemotide are derived from the mucin 1 (MUC1) sequence: human mucin-1 (carcinoma-associated mucin ... doi:10.1007/s00432-011-1003-3 Merck KGaA to test Stimuvax in breast cancer trial (FierceVaccines) UPDATE 2-Merck to test ... doi:10.1016/S1470-2045(13)70510-2 Merck Discontinues Clinical Development Program of Tecemotide as a Monotherapy in Stage III ...
InChI=1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12) Y ... 1][2] as well as poisoning from other sedative drugs[3][4] and treatment of respiratory failure from other causes.[5] It was ... 35 (1): 17-21. doi:10.1111/j.1365-2044.1980.tb03714.x. PMID 6994518.. ...
Hollars, C W; Dunn, R C (1998). "Submicron Structure in l--Dipalmitoylphosphatidylcholine Monolayers and Bilayers Probed with ... doi:10.1007/978-1-62703-782-2_7. ISBN 978-1-62703-781-5. PMID 24395412. Roos, C; Kai, L; Proverbio, D; Ghoshdastider, U; ... 75 (1): 342-353. Bibcode:1998BpJ....75..342H. doi:10.1016/s0006-3495(98)77518-6. PMC 1299703 . PMID 9649391. J T Groves, N ... The size and nature of this gap depends on the substrate material and lipid species but is generally about 1 nm for ...
40% dipalmitoylphosphatidylcholine (DPPC); ~40% other phospholipids (PC); ~10% surfactant proteins (SP-A, SP-B, SP-C and SP-D ... Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid with two 16-carbon saturated chains and a phosphate group with ... Up to 90% of surfactant DPPC (dipalmitoyl phosphatidylcholine) is recycled from the alveolar space back into the type II ... dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. As a medication, pulmonary surfactant is on the WHO Model List ...
Dipalmitoyl phosphatidylcholine (a.k.a. lecithin) is a major component of pulmonary surfactant and is often used in the L/S ... Animal lung phosphatidylcholine, for example, contains a high proportion of Dipalmitoylphosphatidylcholine. Phospholipase D ... 86 (2): 163-171. doi:10.1079/BJN2001391. Chung, Shu-Ying; Moriyama, Tomoe; Uezu, Eiko; Uezu, Kayoko; Hirata, Rieko; Yohena, ... 4 (2): 135. doi:10.4103/0974-2077.85040. ISSN 0974-2077. Treacy, PJ; Goldberg, DJ (2006). "Use of phosphatidylcholine for the ...
8 (2): 241-242. doi:10.1021/je60017a033.. *^ a b c d Triacetin in Linstrom, Peter J.; Mallard, William G. (eds.); NIST ... The triglyceride 1,2,3-triacetoxypropane is more generally known as triacetin and glycerin triacetate. It is the triester of ... InChI=1S/C9H14O6/c1-6(10)13-4-9(15-8(3)12)5-14-7(2)11/h9H,4-5H2,1-3H3 Y ... Soluble in C6H6, (C2H5)2O, acetone[2] ... 1.4301 (20 °C)[2]. 1.4294 (24.5 °C)[4] Viscosity 23 cP (20 °C)[ ...
218-. ISBN 978-1-4200-3199-7.. *^ Y. H. Hui (15 February 2008). Bakery Products: Science and Technology. John Wiley & Sons. pp ... Gerard L. Hasenhuettl; Richard W. Hartel (1 January 1997). Food Emulsifiers and Their Applications. Springer. ISBN 978-0-412- ... Several monoglycerides are pharmacologically active (e.g. 2-oleoylglycerol, 2-arachidonoylglycerol[3]). ... "2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans". The Journal of Clinical Endocrinology and ...
21 (1): 80-85. doi:10.1097/GCO.0b013e32831d7f22. PMID 19125007.. *^ Freedman LS, Kipnis V, Schatzkin A, Potischman N (Mar-Apr ... 55 (1-3): 173-201. doi:10.1159/000229002. PMID 19752542.. *^ Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, ... Retrieved 1 March 2014.. *^ Hooper L, Martin N, Abdelhamid A, Davey Smith G (2015). "Reduction in saturated fat intake for ... Retrieved 1 March 2014.. *^ "What are "oils"?". ChooseMyPlate.gov, US Department of Agriculture. 2015. Archived from the ...
ISBN 978-1-4200-9084-0.. *^ a b Ralston, A.W.; Hoerr, C.W. (1942). "The Solubilities of the Normal Saturated Fatty Acids". The ... 25 (2): 191-195. doi:10.1016/S0272-8842(98)00024-8.. *^ Emken, Edward A. (1994). "Metabolism of dietary stearic acid relative ... It is a waxy solid and its chemical formula is C17H35CO2H. Its name comes from the Greek word στέαρ "stéar", which means tallow ... Soluble in alkyl acetates, alcohols, HCOOCH3, phenyls, CS2, CCl4[4] ...
48 (1): 1-8. PMID 3275491.. *^ Berg J, Tymoczko JL, Stryer L (2006). Biochemistry (6th ed.). San Francisco: W. H. Freeman. ISBN ... Diglycerides are a minor component of many seed oils and are normally present at ~1-6%; or in the case of cottonseed oil as ... DAG-enriched oil (particularly 1,3-DAG) has been investigated extensively as a fat substitute due to its ability to suppress ... General chemical structures of 1,2-diacylglycerols (top) and 1,3-diacylglycerols (bottom), where R1 and R2 are fatty acid side ...
ISBN 978-1-4051-3066-0.. *^ a b c Kuzuyama T, Seto H (April 2003). "Diversity of the biosynthesis of the isoprene units". ... 295 (1): 39-49. doi:10.1001/jama.295.1.39. PMID 16391215.. *^ "Fats and Cholesterol: Out with the Bad, In with the Good - What ... 14 (2): 4242-82. doi:10.3390/ijms14024242. PMC 3588097. PMID 23429269.. *^ Michelle A, Hopkins J, McLaughlin CW, Johnson S, ... 5 (1): 40-7. doi:10.1055/s-2005-871740. PMID 15968579.. *^ Astrup A (2008). "Dietary management of obesity". JPEN. Journal of ...
2010: 1-6. doi:10.1155/2010/628171. PMC 2945673. PMID 20886028.. *^ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of ... 39 (1): 3-22. doi:10.1002/cbin.10345. PMID 25052386.. *^ Lim JY, Park CK, Hwang SW (2015). "Biological Roles of Resolvins and ... 7 (2): a016311. doi:10.1101/cshperspect.a016311. PMC 4315926. PMID 25359497.. *^ Serhan CN, Chiang N (2013). "Resolution phase ... 124 (1-3): 121-5. doi:10.1159/000053688. PMID 11306946.. *^ Sarau HM, Foley JJ, Schmidt DB, et al. (1999). "In vitro and in ...
60 (2): 194-200. doi:10.1001/archneur.60.2.194. PMID 12580703.. *^ a b Phivilay A, Julien C, Tremblay C, Berthiaume L, Julien P ... 978-1-4251-3808-0. .. *^ a b Ascherio A, Stampfer MJ, Willett WC. "Trans fatty acids and coronary heart disease". Archived from ... doi:10.1007/978-1-60327-571-2_5. ISBN 9781603275712. .. *^ a b "About Trans Fat and Partially Hydrogenated Oils" (PDF). Center ... 79 (2): 343-50. doi:10.1590/S0001-37652007000200015. PMID 17625687.. *^ a b Food and nutrition board, institute of medicine of ...
1. Archived from the original (PDF) on 17 December 2008.. External links[edit]. Look up trans fat in Wiktionary, the free ... ISBN 978-1-4251-3808-0.. *^ a b Ascherio A, Stampfer MJ, Willett WC. "Trans fatty acids and coronary heart disease". Archived ... 60 (2): 194-200. doi:10.1001/archneur.60.2.194. PMID 12580703.. *^ a b Phivilay, A. (2009). "High dietary consumption of trans ... 79 (2): 343-350. doi:10.1590/S0001-37652007000200015. PMID 17625687.. *^ a b Food and nutrition board, institute of medicine of ...
84 (1): 44-53. doi:10.1093/ajcn/84.1.44. PMID 16825680.. *^ a b c d e DeFilippis AP, Sperling LS (March 2006). "Understanding ... 174 (3): 460-2. doi:10.1001/jamainternmed.2013.12765. PMID 24352849.. *^ a b c d e Ratnayake WM, Galli C (2009). "Fat and fatty ... 26 (1): 33-40. doi:10.1097/YCO.0b013e32835ab4a7. PMID 23108232.. *^ a b Ruxton CH, Calder PC, Reed SC, Simpson MJ (June 2005 ... 63 (1): 66-78. doi:10.3109/09637486.2011.598849. PMID 21762028.. *^ a b Hooper L, Thompson RL, Harrison RA, Summerbell CD, Ness ...
ISBN 1-55643-690-4.. ബാഹ്യ ലിങ്കുകൾ[മൂലരൂപം തിരുത്തുക]. വിക്കിമീഡിയ കോമൺസിലെ Lauric acid എന്ന വർഗ്ഗത്തിൽ ഇതുമായി ബന്ധപ്പെട്ട ... P21/a, No. 14 (α-form)[7]. P1, No. 2 (γ-form)[8] ... 0.442 W/m·K (solid)[1]. 0.1921 W/m·K (72.5 °C). [2] ... Soluble in alcohols, (C2H5)2O, phenyls, haloalkanes, acetates[4] ... 0.8744 g/cm3 (41.5 °C)[1]. 0.8679 g/cm3 (50 °C) ... n-Dodecanoic acid, Dodecylic acid, Dodecoic acid, Laurostearic acid, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, ...
978-1-4051-3066-0. .. *^ a b c Kuzuyama T, Seto H (April 2003). "Diversity of the biosynthesis of the isoprene units". Natural ... 295 (1): 39-49. doi:10.1001/jama.295.1.39. PMID 16391215.. *^ "Fats and Cholesterol: Out with the Bad, In with the Good - What ... 14 (2): 4242-82. doi:10.3390/ijms14024242. PMC 3588097. PMID 23429269.. *^ Michelle A, Hopkins J, McLaughlin CW, Johnson S, ... 5 (1): 40-7. doi:10.1055/s-2005-871740. PMID 15968579.. *^ Astrup A (2008). "Dietary management of obesity". JPEN. Journal of ...
Particulate Delivery Vehicles for Embryoid Bodies - MASSACHUSETTS INSTITUTE OF TECHNOLOGYSuch surfactants include, but are not limited to, phosphoglycerides; phosphatidylcholines; dipalmitoyl phosphatidylcholine ( ... At day 2, the formed EBs were removed from the 96 well-plate and placed in a low-adherent 24 well-plate (4-6 EBs per well). The ... 2] L. S. Ferreira, S. Gerecht, H. F. Shieh, N. Watson, M. A. Rupnick, S. M. Dallabrida, G. Vunjak-Novakovic, R. Langer, Circ ... A) Scanning electron microscopy of particles 25 μm (A.1, A.2), 6 μm (A.3, A.4) and 0.24 μm (A.5, A.6) at day 0 (A.1, A.3, A.5) ...
![PLA2G10 phospholipase A2 group X [Homo sapiens (human)] - Gene - NCBI](data:image/png;base64,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)
PLA2G10 phospholipase A2 group X [Homo sapiens (human)] - Gene - NCBIConserved Domains (1) summary. cd00125. Location:43 → 157. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 119. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 122. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 118. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ...
antioxidant protein 2. non-selenium glutathione peroxidase. thiol-specific antioxidant protein. NP_446028.1. *EC 1.11.1.15 ... Conserved Domains (2) summary. COG0450. Location:5 → 200. AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [ ... 1-Cys PRX. 1-Cys peroxiredoxin. NSGPx. acidic calcium-independent phospholipase A2. aiPLA2. ... The MAPKs can mediate phosphorylation of Prdx6 at Thr-177 with a consequent marked increase in its aiPLA(2) activity. Title: ...
Lipidomics of cellular and secreted phospholipids from differentiated human fetal type II alveolar epithelial cells.1-Methyl-3-isobutylxanthine / pharmacology. 8-Bromo Cyclic Adenosine Monophosphate / metabolism. Cell Differentiation. Cells, ... 9613677 - Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cel.... ... 1). Mixtures of these PC molecular species, phosphatidylglycerol, and SP-B and SP-C were functionally active and rapidly ...
Frontiers | An Eye on the Wnt Inhibitory Factor Wif1 | Cell and Developmental BiologyFIGURE 1. Figure 1. Overview of Wif1 structure and function. The 379 aa Wif1 protein comprises an N-terminal signal sequence ( ... Lucia Poggi1*, Simona Casarosa2 and Matthias Carl3*. *1Laboratory of Molecular and Cellular Ophthalmology, Centre for ... 2009). Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis. J. Cell ... Lee, M. J., Kim, E. J., Li, L., and Jung, H. S. (2015). Roles of Wnt inhibitory factor 1 during tooth morphogenesis. Cell ...
2.. Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain. ... 1.. Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact ... Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. ... Properties of the inositol 3,4,5,6-tetrakisphosphate 1-kinase purified from rat liver. Regulation of enzyme activity by ...
RCSB PDB - 2YGQ: WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2...... like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine ... dipalmitoylphosphatidylcholine. *DOI: 10.2210/pdb2YGQ/pdb. *Classification: SIGNALING PROTEIN. *Organism(s): Homo sapiens ... The six-domain WIF-1 crystal structure shows that EGFs I-V are wrapped back, interfacing with WIF-1(WD) at EGF III. EGFs II-V ... 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE. C40 H80 N O8 P. KILNVBDSWZSGLL-KXQOOQHDSA-N. ...
Pla2g6 - 85/88 kDa calcium-independent phospholipase A2 - Rattus norvegicus (Rat) - Pla2g6 gene & proteinSSF52151 SSF52151, 1 hit. PROSITEi. View protein in PROSITE. PS50297 ANK_REP_REGION, 1 hit. PS50088 ANK_REPEAT, 4 hits. ... 1.25.40.20, 2 hits. InterProi. View protein in InterPro. IPR016035 Acyl_Trfase/lysoPLipase. IPR002110 Ankyrin_rpt. IPR020683 ... 1. Keywords - PTMi. Phosphoprotein. Proteomic databases. PaxDb, a database of protein abundance averages across all three ... LITRK…LNNLE → Q in isoform Short. 1 Publication. ,p>Manually curated information that is based on statements in scientific ...
Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional ... 1 - 20. Sequence analysisAdd BLAST. 20. ,p>This subsection of the PTM / Processing section describes the extent of a ... 1Add BLAST. 309. ,p>This subsection of the Family and Domains section indicates the positions and types of repeated sequence ... 2Add BLAST. 346. ,p>This subsection of the Family and Domains section indicates the positions and types of repeated sequence ...
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases ... 1.20.90.10, 1 hit. InterProi. View protein in InterPro. IPR001211 PLipase_A2. IPR033112 PLipase_A2_Asp_AS. IPR016090 PLipase_ ... Ref.1. "Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung.". Seilhamer J. ... P04054-1 [UniParc]FASTAAdd to basketAdded to basket. « Hide. 10 20 30 40 50. MKLLVLAVLL TVAAADSGIS PRAVWQFRKM IKCVIPGSDP ...
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. ... 1 - 119. Basic phospholipase A2 acanthin-1Add BLAST. 119. Amino acid modifications. Feature key. Position(s). Description ... 1.20.90.10, 1 hit. InterProi. View protein in InterPro. IPR001211 PLipase_A2. IPR033112 PLipase_A2_Asp_AS. IPR016090 PLipase_ ... By similarityNote: Binds 1 Ca2+ ion.By similarity. Sites. Feature key. Position(s). DescriptionActions. Graphical view. Length ...
Combining Molecular Modeling With Experimental Methodologies: Mechanism of Membrane Permeation and Accumulation of Ofloxacin -...Dipalmitoylphosphatidylcholine was used for the preparation of biomembrane models. The influence of environmental conditio … ... Dipalmitoylphosphatidylcholine was used for the preparation of biomembrane models. The influence of environmental conditions ... Massimo Fresta 1 , Salvatore Guccione, Andrea R Beccari, Pio M Furneri, Giovanni Puglisi ... Massimo Fresta 1 , Salvatore Guccione, Andrea R Beccari, Pio M Furneri, Giovanni Puglisi ...
Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked...n = 18 (WT), 10 (D186/D193A), 11 (D51/E52/E55A), 13 (D166/E170A)] and dataset 2 [1 mm Ca2+, 1.2 mm Ca2+, 2 mm Ca2+, 3 mm Ca2+. ... 1D, 8D) and, indeed, the unclamping effect in the cell correlated with a lack of Cpx clamping in vitro (Figs. 1G, 8F). This ... 5A,B; 1 mm). Increasing the [Ca2+] up to 8 mm increased the EPSC amplitude in all mutants (Fig. 5A,B; 8 mm). Remarkably, for ... 7C,D). No rescue of the evoked EPSC amplitude was found after syt-1 OE for any of the mutations (cf. Figs. 7E,F, 3A,B). The ...
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs ... 1 - 25. Sequence analysisAdd BLAST. 25. ,p>This subsection of the PTM / Processing section describes the extent of a ... 1.20.90.10, 1 hit. InterProi. View protein in InterPro. IPR001211 PLipase_A2. IPR036444 PLipase_A2_dom_sf. IPR033113 PLipase_ ... Probable phospholipase A2 homolog 2Add BLAST. 128. Amino acid modifications. Feature key. Position(s). DescriptionActions. ...
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity). ... 1.20.90.10, 1 hit. InterProi. View protein in InterPro. IPR001211 PLipase_A2. IPR033112 PLipase_A2_Asp_AS. IPR016090 PLipase_ ... 1 - 18. 2 Publications. ,p>Manually curated information for which there is published experimental evidence.,/p> ,p>,a href="/ ... Q9PTA1-1 [UniParc]FASTAAdd to basketAdded to basket. « Hide. 10 20 30 40 50. LAVCVSLLGA ANIPPHPLNL INFMEMIRYT IPCEKTWGEY ...
Patente US4312860 - Lung surfactant compositions - Google PatentesThe synthetic surfactant composition consists essentially of a major amount of 1,2-dipalmitoyl-sn-3-glycerophosphoryl choline ( ... and especially n-hexdecan-1-ol. The synthetic surfactant composition is administered directly into the lungs of a distressed ... The dipalmitoyl phosphatidylcholine (DPPC) constitutes the major component of the surfactant composition while the fatty ... A mammalian lung surfactant composition consisting essentially of dipalmitoyl phosphatidylcholine in admixture with a fatty ...
IJMS | Free Full-Text | Phospholipids at the Interface: Current Trends and Challenges | HTML1 1976, 72, 2694-2702. [Google Scholar]. *Alexander, A.E.; Teorell, T.; Rideal, E.K. A study of films at the liquid/liquid ... 1 1976, 72, 2685-2693. [Google Scholar]. *Taylor, J.A.G.; Mingins, J.; Pethica, B.A. Phospholipid monolayers at the n-heptane/ ... Figure 3. (1) Photographs showing a minor part of an aqueous solution at the bottom and a nonaqueous solution above. (A-C) ... Figure 3. (1) Photographs showing a minor part of an aqueous solution at the bottom and a nonaqueous solution above. (A-C) ...
Smith, GB, Taeusch, HW, Phelps, DS & Keough, KMW 1988, Mixtures of low molecular weight surfactant proteins and dipalmitoyl phosphatidylcholine ... These values were not affected by increasing amounts of surfactant protein relative to dipalmitoyl phosphatidylcholine (DPPC). ... These values were not affected by increasing amounts of surfactant protein relative to dipalmitoyl phosphatidylcholine (DPPC). ... These values were not affected by increasing amounts of surfactant protein relative to dipalmitoyl phosphatidylcholine (DPPC). ...
Rabbits received 2 infusions of HDL each containing 25 mg apoA-I (or apoA-II). A 3-kg rabbit with a plasma volume of &120 mL ... Figure 1. Effect of administration of atorvastatin, native and reconstituted HDL on lesion area (mm2) in a rabbit model of ... Infusion of rHDL containing apoA-I:PLPC reduced lesion area by 35% (1.39±0.15 versus 2.13±0.15 mm2 in rHDL-treated and ... Discoidal rHDL containing: (1) apoA-I complexed to 1-palmitoyl-2-linoleoyl phosphatidylcholine (PLPC); (2) apoA-I complexed to ...
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. ... Ref.2. "Isolation of the major lethal toxin in the venom of Bungarus flaviceps.". Khow O., Chanhome L., Omori-Satoh T., ... Ref.2. "Isolation of the major lethal toxin in the venom of Bungarus flaviceps.". Khow O., Chanhome L., Omori-Satoh T., ... 1.20.90.10, 1 hit. InterProi. View protein in InterPro. IPR001211 PLipase_A2. IPR033112 PLipase_A2_Asp_AS. IPR016090 PLipase_ ...
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity). ... 1.20.90.10, 1 hit. InterProi. View protein in InterPro. IPR001211 PLipase_A2. IPR033112 PLipase_A2_Asp_AS. IPR016090 PLipase_ ... By similarityNote: Binds 1 Ca2+ ion.By similarity. Sites. Feature key. Position(s). DescriptionActions. Graphical view. Length ... 1. ,p>This subsection of the Function section is used for enzymes and indicates the residues directly involved in catalysis., ...
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. ... 1 - 118. Basic phospholipase A2 2Add BLAST. 118. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... 1. ,p>This subsection of the Function section indicates at which position the protein binds a given metal ion. The nature of ... 1. ,p>This subsection of the Function section indicates at which position the protein binds a given metal ion. The nature of ...
Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes. ... 1. In the present study the mechanisms were examined by which the neuropeptide galanin modulates the extracellular ... RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT ... Modulation of the inositol 1,4,5-trisphosphate (IP3)-mediated signal transduction pathway by the inhalational anesthetic ...
The Biosynthesis and Hormonal Regulation of Surfactant Formation | Springer for Research & DevelopmentMoreover, approximately 50% of the phosphatidylcholines consist specifically of dipalmitoylphosphatidylcholine (DP-PC). Indeed ... 1.The Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Departments of Biochemistry and Obstetrics- ... The lipid composition of surfactant is illustrated in Figure 1.. Keywords. Amniotic Fluid Phosphatidic Acid Phosphatidic Acid ... 1). It has been demonstrated that the Type II ce1I of the lung synthesizes surfactant, a substance which markedly lowers the ...
Holdings: Transformation of the cryobehavior of rye protoplasts by modification of the plasma membrane lipid composition.... dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine liposomes had no effect. The increased freezing tolerance was ... 1-palmitoyl- 2-linoleoylphosphatidylcholine, or dioleoylphosphatidylcholine liposomes were somewhat less effective; ...
PhospholipidsMonolayersPhosphatidylcholinesBilayersHydrolysisMixturesDistearoylphosphatidylcholineSurfactantDifferentialLiposomalInteractionPhosphateAspergillusPhospholipaseTemperatureLigandsMetabolismAbstractVesiclesPeptideContributionPreparationsSurface tensionInteractionsClaim 1 whereinAcidPharmacology1996MoleculesBiophysical JournalProteinProportionLiposomePhase1981Binds
- Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. (uniprot.org)
- Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). (uniprot.org)
- It is then not surprising that phospholipids properties, such as chemical or crystal structure, self-assembly, hydration, phase transition, etc. have been long studied and are nowadays well understood [ 1 - 3 ]. (mdpi.com)
- We used vesicles of zwitterionic phospholipids, dipalmitoylphosphatidylcholine and ditridecanoylphosphatidycholine ( DTPC ), to represent prebiotic protocols (although we recognize that phospholipids are biologically produced, and that simpler lipids would have existed pre-biotically). (nasa.gov)
- Methods: 1,6-Diphenyl-1,3,5-hexatriene-labeled lipid bilayer membranes were prepared with 1,2-dipalmitoyl-phosphatidylcholine as model membranes and with different phospholipids and cholesterol to mimic neuronal membranes. (oalib.com)
- In the absence of nanoparticles, the monolayers collapse only at very low surface tensions (around 0 mN m −1 ). (royalsocietypublishing.org)
- Our simulation system consisted of two lipid monolayers bounding a water slab ( figure 1 a ). (royalsocietypublishing.org)
- However, the enrichment was dependent on the presence of tethering molecules which kept the curvature high (the curvature radius of ~1 nm), placing the cis monolayers ~2-2.5 nm from each other. (scirp.org)
- Moreover, approximately 50% of the phosphatidylcholines consist specifically of dipalmitoylphosphatidylcholine (DP-PC). (springer.com)
- PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. (uniprot.org)
- Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. (uniprot.org)
- PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. (uniprot.org)
- PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. (uniprot.org)
- FAAH (fatty acid amide hydrolase) is a membrane-bound enzyme that is responsible for the intracellular hydrolysis of the bioactive lipid AEA (anandamide or N -arachidonoylethanolamine) and other congeners known as eCBs (endocannabinoids) [ 1 ]. (biochemj.org)
- Phosphatidylcholine hydrolysis was significantly higher after infusion of egg yolk-phosphatidylcholine compared with infusion of dipalmitoylphosphatidylcholine containing micelles. (elsevier.com)
- Using a pulsating bubble surfactome-ter, we found that inflation pressures of bubbles at minimum radii in these mixtures were 0.34 ± 0.05 cm H 2 0 (± SD, n = 24) after 1 min. (elsevier.com)
- The phospholipid content of the gel phase was rich in dipalmitoylphosphatidylcholine or distearoylphosphatidylcholine, or was entirely Ca(dioleoylphosphatidylserine) 2 . (springer.com)
- Pulmonary surfactant proteins SP-B and SP-C were isolated from lavage fluids of bovine lungs and recombined (lipid/proteins, 9/1, wt/wt) with dipalmitoyl phosphatidylcholine for testing in vitro and in surfactant-deficient adult rats. (elsevier.com)
- Minimum inflation pressures were similar to those of modified bovine surfactant, surfactant Tokyo Akita (TA) (0.33 ± 0.05 cm H 2 0, n = 7). (elsevier.com)
- Treatment of differentiated epithelial cells with secretagogues stimulated the secretion of functional surfactant-containing surfactant proteins B and C (SP-B and SP-C). Secreted material was further enriched in this same set of phospholipid species but was characterized by increased contents of short-chain monounsaturated and disaturated species other than dipalmitoyl PC (PC16:0/16:0), principally palmitoylmyristoyl PC (PC16:0/14:0) and palmitoylpalmitoleoyl PC (PC16:0/16:1). (biomedsearch.com)
- The synthetic surfactant composition consists essentially of a major amount of 1,2-dipalmitoyl-sn-3-glycerophosphoryl. (google.es)
- 1. A mammalian lung surfactant composition consisting essentially of dipalmitoyl phosphatidylcholine in admixture with a fatty alcohol. (google.es)
- 8. A method for treating respiratory distress syndrome in mammals wherein natural lung surfactant normally produced by the mammal is absent or deficient, comprising introducing into the alveolar spaces a quantity of a composition consisting essentially of a major amount of 1,2 dipalmitoyl-sn-3-glycerophosphoryl choline in admixture with a minor amount of a fatty alcohol. (google.es)
- The respiratory distress syndrome (RDS) of the newborn, due to hyaline membrane disease, is caused by an inability of the fetal or neonatal lung to synthesize adequate quantities of the lipoprotein, surfactant (1). (springer.com)
- It has been demonstrated that the Type II ce1I of the lung synthesizes surfactant, a substance which markedly lowers the surface tension of the lung, preventing alveolar collapse (2). (springer.com)
- The lipid composition of surfactant is illustrated in Figure 1. (springer.com)
- Contrary to bigger particles, which get stuck in the upper respiratory ways, nanometre-sized particles can reach the gas-exchange surface in the alveoli [ 1 ], which is lined with a monolayer of lung surfactant [ 4 ]. (royalsocietypublishing.org)
- SP-A, as well as the enzyme lysophosphatidylcholine acyltransferase-1 (LPCAT1), required for synthesis of surfactant dipalmitoylphosphatidylcholine, and the proinflammatory glycerophospholipid platelet-activating factor (PAF) were markedly reduced in SRC-1/-2-deficient fetal lungs near term. (jci.org)
- 2) Design, synthesis, and biophysical studies of sequence-controlled, biomimetic oligomers (synthetic peptide mimics) with helical structures, for biomedical and biomaterial applications (mimicry of lung surfactant proteins, antimicrobial and anticancer innate immune peptides). (stanford.edu)
- Possible changes in surface properties of 1,2-dipalmitoyl- phosphatidylcholine (DPL) and lung surfactant induced by kaolin (1332587) dust were investigated using a Wilhelmy surface balance. (cdc.gov)
- Control and surfactant-treated dusts were used to challenge lavaged rat pulmonary macrophages in vitro over a 1-week period, to determine the effects of adsorbed surfactant on the expression of quartz cytotoxicity and genotoxicity. (cdc.gov)
- Cytotoxicity of surfactant-treated quartz measured one day after challenge of lavaged macrophages was suppressed to values near those of the negative controls, and then increased over a 1 week incubation period to levels near those expressed by native quartz positive controls. (cdc.gov)
- A putative correlation of this cytotoxicity with methoprene-induced perturbations on membrane lipid organization was investigated, using differential scanning calorimetry and the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) and its propionic acid derivative (DPH-PA). (springer.com)
- 1. A composition comprising a liposome encapsulating a single therapeutic agent, wherein said therapeutic agent is loaded into said liposome in the presence ofintra-liposomal copper ions and a divalent proton cation exchange ionophore within the lipid bilayer of said liposome, wherein said divalent proton cation exchange ionophore is A23187. (patentgenius.com)
- When administered intravenously to C57BL/6J mice bearing melanoma B16F1 tumour at 10 mg kg-1 dose, liposomal bleomycin in combination with hyperthermia (43°C, 30 min or 1 h) exhibited improved anticancer activity as evident by the enhanced volume doubling time and growth delay compared with animals treated with an equivalent dose of free bleomycin with or without hyperthermia. (elsevier.com)
- We conclude that three synaptic release functions of syt-1, vesicle priming, spontaneous release clamping, and evoked release triggering, depend on direct SNARE complex interaction. (jneurosci.org)
- Therefore, vesicle priming, clamping spontaneous release, and eliciting evoked release are three different functions of syt-1 that involve different interaction modes with the SNARE complex. (jneurosci.org)
- The interaction of these compounds with salmon sperm DNA was studied using spectroscopic methods, allowing the determination of intrinsic binding constants, Ki = (8.7 ± 0.9) × 103 M-1 for compound 1 and Ki = (5.9 ± 0.6) × 103 M-1 for 2, and binding site sizes of n = 11 ± 3 and n = 7 ± 2 base pairs, respectively. (nih.gov)
- A Phospholipase A1 which is capable of hydrolyzing a phospholipid to produce a 2-acyl lysophospholipid and is obtainable from species of the fungus Aspergillus. (patentgenius.com)
- 7. Phospholipase A1 according to claim 1 which is isolated from Aspergillus oryzae SANK 11870, available under deposit number FERM BP-3887. (patentgenius.com)
- Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival. (nih.gov)
- PLA22_ORYSJ Probable phospholipase A2 homolog 2 OS=Oryza sativa subsp. (uniprot.org)
- 2. The phospholipase A1 according to claim 1 which is stable at a pH of between about pH 3 and about pH 10.5. (patentgenius.com)
- 3. Phospholipase A1 according to claim 1 which has a molecular weight of between about 32,000 and 37,000 daltons as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis. (patentgenius.com)
- 4. The phospholipase A1 according to claim 1 which has a pI under isoelectric point electrophoresis at about pH 3.0 to about pH 4.3. (patentgenius.com)
- 5. The phospholipase A1 according to claim 1 which has an optimum temperature for activity of from about 50.degree. (patentgenius.com)
- 11 . The process of claim 1 , wherein the phospholipid has a phase transition temperature of 40 C. to 60 C. (google.it)
- In mammalian cells, but also in plant cells, [2] cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism . (raypeatforum.com)
- 1993. In vitro percutaneous absorption and metabolism in man of 2-chloro-4-ethylamino-6-isopropylamine-s-triazine (atrazine). (cdc.gov)
- Abstract No. 066261, Zhang Y et al, `Purification and Characterization of aLysophospholipase from a Macrophage-Like Cell Line P388D-1` of J. Biol. (patentgenius.com)
- Abstract No. 004429, NIshijima M. et al, `Detergent Resistant Phospho Lipase A of Escherichia-Coli K-12 Purification and Properties` of Eur J Biochem, 73 (1) 1977 115-124. (patentgenius.com)
- An in vitro assay showed that the region I, region II, and region I+II (D51/E52/E55/D166A) mutants markedly reduced the attachment between syt-1 and t-SNARE-carrying vesicles in the absence of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ]. (jneurosci.org)
- Here, we evaluated the contribution of steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2), which upregulate SP-A transcription, to the parturition process. (jci.org)
- These membrane preparations were treated with phenols and anesthetics at 1 - 200 μM, followed by measuring the fluorescence polarization to determine the membrane interactivities to change membrane fluidity. (oalib.com)
- The gas pressure (P) needed to keep equilibrium between the collapsing force of surface tension (γ) and the expanding force of gas in an alveolus of radius r is expressed by the law of Laplace: P = 2 γ r {\displaystyle P={\frac {2\gamma }{r}}} Compliance is the ability of lungs and thorax to expand. (wikipedia.org)
- A 13-C CP/MAS and 31-P NMR study of the interactions of dipalmitoylphosphatidylcholine with respirable silica and kaolin. (cdc.gov)
- Whether interactions between synaptotagmin-1 (syt-1) and the soluble NSF attachment protein receptors (SNAREs) are required during neurotransmission is debated. (jneurosci.org)
- We examined five SNAP-25 mutations designed to interfere with syt-1 interactions. (jneurosci.org)
- SIGNIFICANCE STATEMENT The function of synaptotagmin-1 (syt-1):soluble NSF attachment protein receptor (SNARE) interactions during neurotransmission remains unclear. (jneurosci.org)
- 3. The method of claim 1 wherein the particles are comprised of a bio-compatible and biodegradable polymer. (freepatentsonline.com)
- 7. The method of claim 1 wherein the cells, after contacting with the microparticles, express CD 34. (freepatentsonline.com)
- 9. The method of claim 1 wherein the particles have a mean diameter in the range between about 0.2 μm and about 25 μm. (freepatentsonline.com)
- 10. The method of claim 1 wherein the particles comprise a protein. (freepatentsonline.com)
- 12. The method of claim 1 wherein the particles comprise DNA. (freepatentsonline.com)
- 15. The method of claim 1 wherein the growth factor is selected from the group comprising vascular endothelial growth factor (VEGF165), basic fibroblast growth factor (bFGF), placenta growth factor (P1GF), and combinations thereof. (freepatentsonline.com)
- 2. The composition of claim 1 wherein the fatty alcohol has from about 14 to 18 carbon atoms. (google.es)
- 5. The composition of claim 1 wherein the dipalmitoyl phosphotidyl choline constitutes a major percentage by weight of the composition and wherein the fatty alcohol constitutes a minor percentage. (google.es)
- 2 . The process of claim 1 wherein the amount of aqueous hydration media used is 30 ml for each mmole of phospholipid in the lipid solution. (google.it)
- 7 . The process of claim 1 , wherein the molar ratio of phospholipid to sterol is from about 1:0.1-1:2. (google.it)
- 9 . The process of claim 1 , wherein the aqueous hydration media comprises ammonium sulfate and sucrose. (google.it)
- 2. The composition as defined in claim 1, wherein said therapeutic agent is an anti-cancer drug. (patentgenius.com)
- Can reduce H 2 O 2 and short chain organic, fatty acid, and phospholipid hydroperoxides. (uniprot.org)
- Pharmacy and Pharmacology Communications , 6 (1), 19-23. (elsevier.com)
- Immortalized Murine Osteoblasts Derived from BMP 2-T-Antigen Expressing Transgenic Mice," Endocrinology (1996) 137:331-339. (patentgenius.com)
- 1996 Apr;270(4 Pt 1):L650-8. (nih.gov)
- Biophysical Journal, 92(2), 440- 447. (scirp.org)
- Biophysical Journal , 25 (2 I), 253-261. (elsevier.com)
- In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. (uniprot.org)
- E ) SP-A protein in 18.5 dpc fetal lung from SRC-1/-2 dhet females × SRC-1/-2 dhet males. (jci.org)
- Representative immunoblot of SP-A protein according to genotype, and data from scans of SP-A immunoblots normalized to β-actin for WT ( n = 6), SRC-1/-2 dhet ( n = 6), and SRC-1/-2 dKO ( n = 4) fetuses. (jci.org)
- F ) SP-A protein in AF surrounding WT and SRC-1/-2- deficient fetuses. (jci.org)
- Here, we performed transcriptional profiling of placentas obtained from smoking mothers who delivered growth-restricted infants and identified secreted frizzled-related protein 1 (sFRP1), an extracellular antagonist of endogenous WNT signaling, as a candidate molecule. (jci.org)
- on Bone Nodule Formation and Expression of Bone Morphogenetic Protein 2, Osteocalcin, Osteopontin, Alkaline Phosphatase, and Type I Collagen mRNA in Long-Term Cultures of Fetal RatCalvarial Osteoblasts,"600 J Bone Miner Res (1994) 9:855-863. (patentgenius.com)
- 1 For example, zinc is the only divalent metal used in the so-called "Zinc-finger" protein motif. (rsc.org)
- C ) Gestation length of SRC-1/-2 dhet females × SRC-1/-2 dhet males is positively correlated with proportion of SRC-1 SRC-2 double-deficient pups. (jci.org)
- Animal lung phosphatidylcholine, for example, contains a high proportion of Dipalmitoylphosphatidylcholine. (wikipedia.org)
- or (3) infusions of HDL (8 mg/kg apolipoprotein A-I) on days 1 and 3 of the treatment phase. (ahajournals.org)
- 4. The method of claim 1 or 2 in which the osmolarity of the suspending solution is less than 25% of that of the internal aqueous phase. (patentgenius.com)
- of Arch Biochem Biophys, 206 (2) 1981. (patentgenius.com)
- Binds 1 Ca 2+ ion per subunit. (uniprot.org)