Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
The characteristic three-dimensional shape of a molecule.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
A change of a substance from one form or state to another.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.
The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.
The physical characteristics and processes of biological systems.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Characteristics or attributes of the outer boundaries of objects, including molecules.
The mixture of gases present in the earth's atmosphere consisting of oxygen, nitrogen, carbon dioxide, and small amounts of other gases.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The force acting on the surface of a liquid, tending to minimize the area of the surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An anionic compound that is used as a reagent for determination of potassium, ammonium, rubidium, and cesium ions. It also uncouples oxidative phosphorylation and forms complexes with biological materials, and is used in biological assays.
Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.
Materials in intermediate state between solid and liquid.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.
Mixtures of many components in inexact proportions, usually natural, such as PLANT EXTRACTS; VENOMS; and MANURE. These are distinguished from DRUG COMBINATIONS which have only a few components in definite proportions.
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
A benzofuran derivative used as a protein reagent since the terminal N-NBD-protein conjugate possesses interesting fluorescence and spectral properties. It has also been used as a covalent inhibitor of both beef heart mitochondrial ATPase and bacterial ATPase.
A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.
A class of sphingolipids found largely in the brain and other nervous tissue. They contain phosphocholine or phosphoethanolamine as their polar head group so therefore are the only sphingolipids classified as PHOSPHOLIPIDS.
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.
Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)
A naphthalene derivative with carcinogenic action.
The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.
Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.
The diversion of RADIATION (thermal, electromagnetic, or nuclear) from its original path as a result of interactions or collisions with atoms, molecules, or larger particles in the atmosphere or other media. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3.1.-.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Measurement of the intensity and quality of fluorescence.
Salts and esters of the 12-carbon saturated monocarboxylic acid--lauric acid.
The rate dynamics in chemical or physical systems.
Computer-based representation of physical systems and phenomena such as chemical processes.
A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.
A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.
The accumulation of an electric charge on a object
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.
The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Physical motion, i.e., a change in position of a body or subject as a result of an external force. It is distinguished from MOVEMENT, a process resulting from biological activity.
Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Relating to the size of solids.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
... contains the peptide sinapultide (KL4 acetate, KLLLLKLLLLKLLLLKLLLLK), dipalmitoylphosphatidylcholine, 1-palmitoyl- ... 2-oleoyl-sn-glycero-3-phosphoglycerol (as the sodium salt), and palmitic acid.[citation needed] The scientific groundwork for ...
25-hydroxyvitamin d 2 MeSH D10.570.938.590 - lanosterol MeSH D10.627.430.354 - cod liver oil MeSH D10.627.430.450 - fatty acids ... 1-butanol MeSH D10.289.110.220 - chlorobutanol MeSH D10.289.110.855 - tert-butyl alcohol MeSH D10.289.220.720 - sodium dodecyl ... 1,2-dipalmitoylphosphatidylcholine MeSH D10.570.755.375.760.400.840 - phosphatidylethanolamines MeSH D10.570.755.375.760.400. ... sulfate MeSH D10.289.230.250 - dolichol phosphates MeSH D10.289.600.610 - 1-octanol MeSH D10.351.801.632 - triacetin MeSH ...
The SNALPs (around 81 nm in size here) were formulated by spontaneous vesiculation from a mixture of cholesterol, dipalmitoyl phosphatidylcholine ... Further, only 2 of the 6 mice treated had noticeable tumors around the implantation site. Even so, GAPDH, a tumor-derived ... Researchers tested a 1 mg/kg single dose, too, obtaining a 68% silencing of the target gene, indicating dose-dependent ... According to the study, a 2 mg/kg dose of PLK1-specific siRNA administered for 3 weeks to mice implanted with tumors resulted ...
... investigated as potential amphiphilic species for aiding adsorption of the pulmonary surfactant dipalmitoylphosphatidylcholine ... 1-Pentadecanol is an organic chemical compound classified as an alcohol. At room temperature, it is a white, flaky solid. It is ... Small amounts of 1-pentadecanol have been found (using thin-layer chromatography and GC/MS) to naturally occur in the leaves of ... It, along with 1-hexadecanol, was found to be selectively antimicrobial against P. acnes and not other Gram-positive bacteria ( ...
... (DPPC) is a phospholipid (and a lecithin) consisting of two C16 palmitic acid groups attached to ... Dipalmitoylphosphatidylcholine (DPPC) is routinely used to formulate some medicines used for treatment of respiratory distress ... "Dipalmitoylphosphatidylcholine - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2019-10-25. Wang, Min; ... is dipalmitoylphosphatidylcholine or DPPC. While DPPC itself already has the ability to reduce the surface tension of the ...
... and dipalmitoyl phosphatidylcholine (DPPC) Function: Structure of the liposome Enhances uptake by APCs The antigen tecemotide ... 2 (Supplement 4): S199-201. doi:10.1097/01.JTO.0000282977.65747.30. Merck KGaA to test Stimuvax in breast cancer trial ( ... The first 25 amino acids of tecemotide are derived from the mucin 1 (MUC1) sequence: human mucin-1 (carcinoma-associated mucin ... Tecemotide clinical trials (as of September 2, 2014) sorted by (Estimated) Primary Completion Date: Overview of completed ...
40% dipalmitoylphosphatidylcholine (DPPC); ~40% other phospholipids (PC); ~10% surfactant proteins (SP-A, SP-B, SP-C and SP-D ... Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid with two 16-carbon saturated chains and a phosphate group with ... Up to 90% of surfactant DPPC (dipalmitoylphosphatidylcholine) is recycled from the alveolar space back into the type II ... dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. As a medication, pulmonary surfactant is on the WHO Model List ...
... and pulmonary surfactants such as dipalmitoylphosphatidylcholine. Trimethylglycine (trivial name betaine) Example of a ... H 2N(R)CO 2H + H 2O ⇌ H 2N(R)CO− 2 + H 3O+ In the other stage a proton is transferred from the hydronium ion to the amine group ... K = [ H 3 N + ( R ) C O 2 − ] [ H 2 N ( R ) C O 2 H ] {\displaystyle K=\mathrm {\frac {[H_{3}N^{+}(R)CO_{2}^{-}]}{[H_{2}N(R)CO ... ISBN 978-1-285-60719-1.CS1 maint: numeric names: authors list (link) Jensen, Jan H.; Gordon, Mark S. (1995). "On the Number of ...
The first trials of a potential treatment for HMD, dipalmitoylphosphatidylcholine, were published within a few years but were ... p. 1. Clarke, Thurston (July 1, 2013). "How "Icebergs" John F. and Jackie Kennedy Warmed to One Another After the Death of ... The infant's birth weight was 4 pounds 10 12 ounces (2.11 kg). He was the first baby to be born to a serving US president and ... 101 (1): 8-12. doi:10.1159/000325162. PMID 21791934. President John F. Kennedy on the Death of His Infant Son Patrick Bouvier ...
InChI=1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12) Y ... 1][2] as well as poisoning from other sedative drugs[3][4] and treatment of respiratory failure from other causes.[5] It was ... 35 (1): 17-21. doi:10.1111/j.1365-2044.1980.tb03714.x. PMID 6994518.. ...
Hollars CW, Dunn RC (July 1998). "Submicron structure in L-alpha-dipalmitoylphosphatidylcholine monolayers and bilayers probed ... doi:10.1007/978-1-62703-782-2_7. ISBN 978-1-62703-781-5. PMID 24395412. Roos C, Kai L, Proverbio D, Ghoshdastider U, Filipek S ... 59 (2): 289-94. doi:10.1016/S0006-3495(91)82222-6. PMC 1281145. PMID 2009353. Kühner M, Tampé R, Sackmann E (July 1994). "Lipid ... 1666 (1-2): 105-17. doi:10.1016/j.bbamem.2004.04.011. PMID 15519311. Cavagnero S, Dyson HJ, Wright PE (April 1999). "Improved ...
DPPC (dipalmitoylphosphatidylcholine), as mentioned above, is a lipid with very useful stabilizing and compacting attributes. ... The lipid shown to be most needed on this surface (Dipalmitoylphosphatidylcholine) does not easily move to the gas/fluid ... 27 (1): 24-9. doi:10.2500/ajra.2013.27.3838. PMID 23406594. S2CID 34564655. Sarker M, Rose J, McDonald M, Morrow MR, Booth V ( ... 178 (2): 256-60. doi:10.1016/j.resp.2011.06.019. PMID 21736957. S2CID 30847636. Simonato M, Baritussio A, Ori C, Vedovelli L, ...
8 (2): 241-242. doi:10.1021/je60017a033.. *^ a b c d Triacetin in Linstrom, Peter J.; Mallard, William G. (eds.); NIST ... The triglyceride 1,2,3-triacetoxypropane is more generally known as triacetin and glycerin triacetate. It is the triester of ... InChI=1S/C9H14O6/c1-6(10)13-4-9(15-8(3)12)5-14-7(2)11/h9H,4-5H2,1-3H3 Y ... Soluble in C6H6, (C2H5)2O, acetone[2] ... 1.4301 (20 °C)[2]. 1.4294 (24.5 °C)[4] Viscosity 23 cP (20 °C)[ ...
Dipalmitoyl phosphatidylcholine (a.k.a. lecithin) is a major component of pulmonary surfactant and is often used in the L/S ... Animal lung phosphatidylcholine, for example, contains a high proportion of dipalmitoylphosphatidylcholine. Phospholipase D ... 4 (2): 135-7. doi:10.4103/0974-2077.85040. PMC 3183720. PMID 21976907. Kokkinidis DG, Bosdelekidou EE, Iliopoulou SM, Tassos AG ... Phosphatidylcholines at the US National Library of Medicine Medical Subject Headings (MeSH) [1]. ...
218-. ISBN 978-1-4200-3199-7.. *^ Y. H. Hui (15 February 2008). Bakery Products: Science and Technology. John Wiley & Sons. pp ... Gerard L. Hasenhuettl; Richard W. Hartel (1 January 1997). Food Emulsifiers and Their Applications. Springer. ISBN 978-0-412- ... Several monoglycerides are pharmacologically active (e.g. 2-oleoylglycerol, 2-arachidonoylglycerol[3]). ... "2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans". The Journal of Clinical Endocrinology and ...
... from the content of phosphorus and contains 55 mg of phosphotidylcholine of which 30 mg is dipalmitoylphosphatidylcholine. ... Each milliliter of poractant alfa contains 80 mg of surfactant (extract) that includes 76 mg of phospholipids and 1 mg of ... and that infants treated at birth had similar neurodevelopmental status to untreated controls at a corrected age of 2 years. ...
21 (1): 80-85. doi:10.1097/GCO.0b013e32831d7f22. PMID 19125007.. *^ Freedman LS, Kipnis V, Schatzkin A, Potischman N (Mar-Apr ... 55 (1-3): 173-201. doi:10.1159/000229002. PMID 19752542.. *^ Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, ... Retrieved 1 March 2014.. *^ Hooper L, Martin N, Abdelhamid A, Davey Smith G (2015). "Reduction in saturated fat intake for ... Retrieved 1 March 2014.. *^ "What are "oils"?". ChooseMyPlate.gov, US Department of Agriculture. 2015. Archived from the ...
ISBN 978-1-4200-9084-0.. *^ a b Ralston, A.W.; Hoerr, C.W. (1942). "The Solubilities of the Normal Saturated Fatty Acids". The ... 25 (2): 191-195. doi:10.1016/S0272-8842(98)00024-8.. *^ Emken, Edward A. (1994). "Metabolism of dietary stearic acid relative ... It is a waxy solid and its chemical formula is C17H35CO2H. Its name comes from the Greek word στέαρ "stéar", which means tallow ... Soluble in alkyl acetates, alcohols, HCOOCH3, phenyls, CS2, CCl4[4] ...
48 (1): 1-8. PMID 3275491.. *^ Berg J, Tymoczko JL, Stryer L (2006). Biochemistry (6th ed.). San Francisco: W. H. Freeman. ISBN ... Diglycerides are a minor component of many seed oils and are normally present at ~1-6%; or in the case of cottonseed oil as ... DAG-enriched oil (particularly 1,3-DAG) has been investigated extensively as a fat substitute due to its ability to suppress ... General chemical structures of 1,2-diacylglycerols (top) and 1,3-diacylglycerols (bottom), where R1 and R2 are fatty acid side ...
ISBN 978-1-4051-3066-0.. *^ a b c Kuzuyama T, Seto H (April 2003). "Diversity of the biosynthesis of the isoprene units". ... 295 (1): 39-49. doi:10.1001/jama.295.1.39. PMID 16391215.. *^ "Fats and Cholesterol: Out with the Bad, In with the Good - What ... 14 (2): 4242-82. doi:10.3390/ijms14024242. PMC 3588097. PMID 23429269.. *^ Michelle A, Hopkins J, McLaughlin CW, Johnson S, ... 5 (1): 40-7. doi:10.1055/s-2005-871740. PMID 15968579.. *^ Astrup A (2008). "Dietary management of obesity". JPEN. Journal of ...
2010: 1-6. doi:10.1155/2010/628171. PMC 2945673. PMID 20886028.. *^ Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of ... 39 (1): 3-22. doi:10.1002/cbin.10345. PMID 25052386.. *^ Lim JY, Park CK, Hwang SW (2015). "Biological Roles of Resolvins and ... 7 (2): a016311. doi:10.1101/cshperspect.a016311. PMC 4315926. PMID 25359497.. *^ Serhan CN, Chiang N (2013). "Resolution phase ... 124 (1-3): 121-5. doi:10.1159/000053688. PMID 11306946.. *^ Sarau HM, Foley JJ, Schmidt DB, et al. (1999). "In vitro and in ...
60 (2): 194-200. doi:10.1001/archneur.60.2.194. PMID 12580703.. *^ a b Phivilay A, Julien C, Tremblay C, Berthiaume L, Julien P ... 978-1-4251-3808-0. .. *^ a b Ascherio A, Stampfer MJ, Willett WC. "Trans fatty acids and coronary heart disease". Archived from ... doi:10.1007/978-1-60327-571-2_5. ISBN 9781603275712. .. *^ a b "About Trans Fat and Partially Hydrogenated Oils" (PDF). Center ... 79 (2): 343-50. doi:10.1590/S0001-37652007000200015. PMID 17625687.. *^ a b Food and nutrition board, institute of medicine of ...
1. Archived from the original (PDF) on 17 December 2008.. External links[edit]. Look up trans fat in Wiktionary, the free ... ISBN 978-1-4251-3808-0.. *^ a b Ascherio A, Stampfer MJ, Willett WC. "Trans fatty acids and coronary heart disease". Archived ... 60 (2): 194-200. doi:10.1001/archneur.60.2.194. PMID 12580703.. *^ a b Phivilay, A. (2009). "High dietary consumption of trans ... 79 (2): 343-350. doi:10.1590/S0001-37652007000200015. PMID 17625687.. *^ a b Food and nutrition board, institute of medicine of ...
84 (1): 44-53. doi:10.1093/ajcn/84.1.44. PMID 16825680.. *^ a b c d e DeFilippis AP, Sperling LS (March 2006). "Understanding ... 174 (3): 460-2. doi:10.1001/jamainternmed.2013.12765. PMID 24352849.. *^ a b c d e Ratnayake WM, Galli C (2009). "Fat and fatty ... 18 (1): 113-29. doi:10.1079/nrr200497. PMID 19079899.. *^ a b Montgomery P, Richardson AJ (April 2008). "Omega-3 fatty acids ... Omega−3 fatty acids, also called Omega-3 oils, ω−3 fatty acids or n−3 fatty acids,[1] are polyunsaturated fatty acids (PUFAs) ...
ISBN 1-55643-690-4.. ബാഹ്യ ലിങ്കുകൾ[മൂലരൂപം തിരുത്തുക]. വിക്കിമീഡിയ കോമൺസിലെ Lauric acid എന്ന വർഗ്ഗത്തിൽ ഇതുമായി ബന്ധപ്പെട്ട ... P21/a, No. 14 (α-form)[7]. P1, No. 2 (γ-form)[8] ... 0.442 W/m·K (solid)[1]. 0.1921 W/m·K (72.5 °C). [2] ... Soluble in alcohols, (C2H5)2O, phenyls, haloalkanes, acetates[4] ... 0.8744 g/cm3 (41.5 °C)[1]. 0.8679 g/cm3 (50 °C) ... n-Dodecanoic acid, Dodecylic acid, Dodecoic acid, Laurostearic acid, Vulvic acid, 1-Undecanecarboxylic acid, Duodecylic acid, ...
978-1-4051-3066-0. .. *^ a b c Kuzuyama T, Seto H (April 2003). "Diversity of the biosynthesis of the isoprene units". Natural ... 295 (1): 39-49. doi:10.1001/jama.295.1.39. PMID 16391215.. *^ "Fats and Cholesterol: Out with the Bad, In with the Good - What ... 14 (2): 4242-82. doi:10.3390/ijms14024242. PMC 3588097. PMID 23429269.. *^ Michelle A, Hopkins J, McLaughlin CW, Johnson S, ... 5 (1): 40-7. doi:10.1055/s-2005-871740. PMID 15968579.. *^ Astrup A (2008). "Dietary management of obesity". JPEN. Journal of ...
Y1 - 2010/2. N2 - The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimers disease ( ... 2, 02.2010, p. 145-148.. Research output: Contribution to journal › Article › peer-review ... Fingerprint Dive into the research topics of Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine ... Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane. Journal of Bioscience and ...
Such surfactants include, but are not limited to, phosphoglycerides; phosphatidylcholines; dipalmitoyl phosphatidylcholine ( ... At day 2, the formed EBs were removed from the 96 well-plate and placed in a low-adherent 24 well-plate (4-6 EBs per well). The ... 2] L. S. Ferreira, S. Gerecht, H. F. Shieh, N. Watson, M. A. Rupnick, S. M. Dallabrida, G. Vunjak-Novakovic, R. Langer, Circ ... A) Scanning electron microscopy of particles 25 μm (A.1, A.2), 6 μm (A.3, A.4) and 0.24 μm (A.5, A.6) at day 0 (A.1, A.3, A.5) ...
Conserved Domains (1) summary. cd00125. Location:43 → 157. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 119. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 122. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ... Conserved Domains (1) summary. cd00125. Location:43 → 118. PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic ...
antioxidant protein 2. non-selenium glutathione peroxidase. thiol-specific antioxidant protein. NP_446028.1. *EC 1.11.1.15 ... Conserved Domains (2) summary. COG0450. Location:5 → 200. AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [ ... 1-Cys PRX. 1-Cys peroxiredoxin. NSGPx. acidic calcium-independent phospholipase A2. aiPLA2. ... The MAPKs can mediate phosphorylation of Prdx6 at Thr-177 with a consequent marked increase in its aiPLA(2) activity. Title: ...
Both dipalmitoyl phosphatidylcholine (DPPC) and dimyristoyl phosphatidylethanolamine (DMPE) lipids, which form stable ... 1 Max Planck Institute of Colloids and Interfaces, Am Muhlenberg 1, D14424 Golm/Potsdam, Germany. ...
WNT INHIBITORY FACTOR 1. A. 188. Homo sapiens. Mutation(s): 1 Gene Names: WIF1, UNQ191/PRO217. ... 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE. C40 H80 N O8 P. KILNVBDSWZSGLL-KXQOOQHDSA-N. Ligand Interaction. ... 2-acetamido-2-deoxy-beta-D-glucopyranose. C8 H15 N O6. OVRNDRQMDRJTHS-FMDGEEDCSA-N. Ligand Interaction. ... The six-domain WIF-1 crystal structure shows that EGFs I-V are wrapped back, interfacing with WIF-1(WD) at EGF III. EGFs II-V ...
1 Department of Membrane Biochemistry and Neurochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel. ...
1-Methyl-3-isobutylxanthine / pharmacology. 8-Bromo Cyclic Adenosine Monophosphate / metabolism. Cell Differentiation. Cells, ... 9613677 - Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cel.... ... 1). Mixtures of these PC molecular species, phosphatidylglycerol, and SP-B and SP-C were functionally active and rapidly ...
FIGURE 1. Figure 1. Overview of Wif1 structure and function. The 379 aa Wif1 protein comprises an N-terminal signal sequence ( ... Lucia Poggi1*, Simona Casarosa2 and Matthias Carl3*. *1Laboratory of Molecular and Cellular Ophthalmology, Centre for ... 2009). Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis. J. Cell ... Lee, M. J., Kim, E. J., Li, L., and Jung, H. S. (2015). Roles of Wnt inhibitory factor 1 during tooth morphogenesis. Cell ...
... like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine ... dipalmitoylphosphatidylcholine. *DOI: 10.2210/pdb2YGQ/pdb. *Classification: SIGNALING PROTEIN. *Organism(s): Homo sapiens ... The six-domain WIF-1 crystal structure shows that EGFs I-V are wrapped back, interfacing with WIF-1(WD) at EGF III. EGFs II-V ... 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE. C40 H80 N O8 P. KILNVBDSWZSGLL-KXQOOQHDSA-N. ...
Jenks, C. J., 2020, I: Classroom Discourse. 11, 2, s. 99-106 8 s.. Publikation: Bidrag til tidsskrift › Tidsskriftartikel › ... Vihrs, N., Møller, J. & Gelfand, A. E., 2020, I: arXiv.org (e-prints). s. 1-37. Publikation: Bidrag til tidsskrift › ... LI, C., Schou, C. & Qi, Y., 1 aug. 2020, I: International Journal of Performability Engineering. 16, 6, s. 834-845 12 s.. ... Matthiesen, N. C. L., 2020, I: Ethnography and Education. 15, 1, s. 1-16 16 s.. Publikation: Bidrag til tidsskrift › ...
SSF52151 SSF52151, 1 hit. PROSITEi. View protein in PROSITE. PS50297 ANK_REP_REGION, 1 hit. PS50088 ANK_REPEAT, 4 hits. ... 1.25.40.20, 2 hits. InterProi. View protein in InterPro. IPR016035 Acyl_Trfase/lysoPLipase. IPR002110 Ankyrin_rpt. IPR020683 ... 1. Keywords - PTMi. Phosphoprotein. Proteomic databases. PaxDb, a database of protein abundance averages across all three ... LITRK…LNNLE → Q in isoform Short. 1 Publication. ,p>Manually curated information that is based on statements in scientific ...
Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional ... 1 - 20. Sequence analysisAdd BLAST. 20. ,p>This subsection of the PTM / Processing section describes the extent of a ... 1Add BLAST. 309. ,p>This subsection of the Family and Domains section indicates the positions and types of repeated sequence ... 2Add BLAST. 346. ,p>This subsection of the Family and Domains section indicates the positions and types of repeated sequence ...
Smith, GB, Taeusch, HW, Phelps, DS & Keough, KMW 1988, Mixtures of low molecular weight surfactant proteins and dipalmitoyl phosphatidylcholine ... These values were not affected by increasing amounts of surfactant protein relative to dipalmitoyl phosphatidylcholine (DPPC). ... These values were not affected by increasing amounts of surfactant protein relative to dipalmitoyl phosphatidylcholine (DPPC). ... These values were not affected by increasing amounts of surfactant protein relative to dipalmitoyl phosphatidylcholine (DPPC). ...
Rabbits received 2 infusions of HDL each containing 25 mg apoA-I (or apoA-II). A 3-kg rabbit with a plasma volume of &120 mL ... Figure 1. Effect of administration of atorvastatin, native and reconstituted HDL on lesion area (mm2) in a rabbit model of ... Infusion of rHDL containing apoA-I:PLPC reduced lesion area by 35% (1.39±0.15 versus 2.13±0.15 mm2 in rHDL-treated and ... Discoidal rHDL containing: (1) apoA-I complexed to 1-palmitoyl-2-linoleoyl phosphatidylcholine (PLPC); (2) apoA-I complexed to ...
n = 18 (WT), 10 (D186/D193A), 11 (D51/E52/E55A), 13 (D166/E170A)] and dataset 2 [1 mm Ca2+, 1.2 mm Ca2+, 2 mm Ca2+, 3 mm Ca2+. ... 1D, 8D) and, indeed, the unclamping effect in the cell correlated with a lack of Cpx clamping in vitro (Figs. 1G, 8F). This ... 5A,B; 1 mm). Increasing the [Ca2+] up to 8 mm increased the EPSC amplitude in all mutants (Fig. 5A,B; 8 mm). Remarkably, for ... 7C,D). No rescue of the evoked EPSC amplitude was found after syt-1 OE for any of the mutations (cf. Figs. 7E,F, 3A,B). The ...
The synthetic surfactant composition consists essentially of a major amount of 1,2-dipalmitoyl-sn-3-glycerophosphoryl choline ( ... and especially n-hexdecan-1-ol. The synthetic surfactant composition is administered directly into the lungs of a distressed ... The dipalmitoyl phosphatidylcholine (DPPC) constitutes the major component of the surfactant composition while the fatty ... A mammalian lung surfactant composition consisting essentially of dipalmitoyl phosphatidylcholine in admixture with a fatty ...
1 1976, 72, 2694-2702. [Google Scholar]. *Alexander, A.E.; Teorell, T.; Rideal, E.K. A study of films at the liquid/liquid ... 1 1976, 72, 2685-2693. [Google Scholar]. *Taylor, J.A.G.; Mingins, J.; Pethica, B.A. Phospholipid monolayers at the n-heptane/ ... Figure 3. (1) Photographs showing a minor part of an aqueous solution at the bottom and a nonaqueous solution above. (A-C) ... Figure 3. (1) Photographs showing a minor part of an aqueous solution at the bottom and a nonaqueous solution above. (A-C) ...
... dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine liposomes had no effect. The increased freezing tolerance was ... 1-palmitoyl- 2-linoleoylphosphatidylcholine, or dioleoylphosphatidylcholine liposomes were somewhat less effective; ...
Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes. ... 1. In the present study the mechanisms were examined by which the neuropeptide galanin modulates the extracellular ... RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT ... Modulation of the inositol 1,4,5-trisphosphate (IP3)-mediated signal transduction pathway by the inhalational anesthetic ...
Moreover, approximately 50% of the phosphatidylcholines consist specifically of dipalmitoylphosphatidylcholine (DP-PC). Indeed ... 1.The Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Departments of Biochemistry and Obstetrics- ... The lipid composition of surfactant is illustrated in Figure 1.. Keywords. Amniotic Fluid Phosphatidic Acid Phosphatidic Acid ... 1). It has been demonstrated that the Type II ce1I of the lung synthesizes surfactant, a substance which markedly lowers the ...
Determining the effects of PEI adsorption on the permeability of 1,2-dipalmitoylphosphatidylcholine/bis(monoacylglycero) ...
Lucinactant contains the peptide sinapultide (KL4 acetate, KLLLLKLLLLKLLLLKLLLLK), dipalmitoylphosphatidylcholine, 1-palmitoyl- ... 2-oleoyl-sn-glycero-3-phosphoglycerol (as the sodium salt), and palmitic acid.[citation needed] The scientific groundwork for ...
A phosphorous-31 nuclear magnetic resonance study of oriented monodomain dipalmitoylphosphatidylcholine bilayers, Biochemistry ... 2. l3C-nmr study of the chain dynamics and solution structure of Bombyx mori silk fibroin, Macromolecules 17:1075.CrossRef ... Enthalpies and entropies of reactions M + (H2O)n-1 + H2O = M + (H2O)n, J. Phys. Chem. 74:1466.CrossRefGoogle Scholar ... 1 (L. J. Berliner and J. Reuben, eds.), Plenum Publishing Corp., New York, pp. 1-32.Google Scholar ...
1)This construct, known as the fluid mosaic hypothesis, contains two... ... A calorimetric and fluorescent probe study of the gel-liquid crystalline phase transition in small, single-lamellar di-palmitoylphosphatidylcholine ... 1.. Singer, S. J., and G. L. Nicolson. 1972. The fluid mosaic model of the structure of cell membranes. Science 175: 720-731. ... 2.. Danielle, J. F., and H. Davson. 1935. A contribution to the theory of the permeability of thin films. J. Cell. Comp. ...
Vesicles preparation.The zwitterionic phospholipid dipalmitoylphosphatidylcholine (DPPC) was purchased from Avanti Polar Lipids ... with dipalmitoylphosphatidylcholine liposomal membranes. Both peptides show the ability to interact with the zwitterionic ... 2). The shifting of the band located at 1,620 cm−1 to 1,628 cm−1 is notable (Table 2). Therefore, it is possible that two types ... 1. Two main bands, around 2,800 and 3,100 cm−1, dominate the spectra in this region and are assigned to the antisymmetric (vas ...
1. A novel mechanism for the Na-K ATPase, Yager, P., J. Theor. Biol., 66, 1-11 (1977). 2. Interpretation of biomembrane ... 2, Jensen, K.F., Han, J., Harrison, D.J. and Voldman, J., Eds., Transducer Research Foundation, Pubs., 1443-1445 (2005). 49. A ... 1, Kitamori, T., Fujita, H., and Hasebe, S., Eds., Society for Chemistry and Micro-Nano Systems, Pubs., 825-827 (2006).. 52. A ... Cryst., 167, 1-6 (1989). 29. An optical method for detecting anesthetics and other lipid-soluble compounds, Merlo, S., Burgess ...
wherein the phospholipid is selected from the group consisting of Distearoyl phosphatidylcholine (DSPC), Dipalmitoyl phosphatidylcholine ... Dipalmitoyl phosphatidylcholine (DPPC), Hydrogenated soya phosphatidylcholine (HSPC) and derivatives of such phospholipids. A ... or Dipalmitoyl phosphatidylcholine (DPPC), Hydrogenated soya phosphatidylcholine (HSPC) or derivatives of such phospholipids. ... 2. The process of claim 1. wherein the amount of aqueous hydration media used is 30 ml for each mmole of phospholipid in the ...
Application of [DiPalmitoyl-1-14C]Phosphatidylcholine can be found in: in vivo evaluation of lipid nanocapsules as a promising ... 10 µCi quantities of L-α-DiPalmitoyl-[DiPalmitoyl-1-14C]-Phosphatidylcholine are available for your research. ... 10 µCi quantities of L-a-DiPalmitoyl-[DiPalmitoyl-1-14C]-Phosphatidylcholine are available for your research. ... effect of pesticide fenitrothion on dipalmitoyl and 1-palmitoyl-2-oleoylphosphatidylcholine bilayers, protein kinase C ...

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